CN113384395A

CN113384395A - Accurate device of dosing of eye

Info

Publication number: CN113384395A
Application number: CN202110832455.XA
Authority: CN
Inventors: 殷莉莉; 张蕾; 郦诗宇; 冯瑶; 何向东
Original assignee: Shenyang Eye Industry Technology Research Institute Co ltd; Shenyang Heshi Eye Industry Group Co ltd
Current assignee: Shenyang Eye Industry Technology Research Institute Co ltd; Shenyang Heshi Eye Industry Group Co ltd
Priority date: 2021-07-22
Filing date: 2021-07-22
Publication date: 2021-09-14

Abstract

The invention discloses an accurate eye drug delivery device, which comprises a flexible bottle body, an inner plug and an outer cover, wherein the inner plug and the outer cover are arranged on the bottle body; the inner plug comprises a liquid outlet, a medicine storage cavity, a control valve and a liquid conveying pipe, the medicine storage cavity is formed between the control valve and the liquid outlet, one end of the liquid conveying pipe is communicated with the control valve, and the other end of the liquid conveying pipe is inserted into the inner cavity of the inner-layer bottle body and extends to a position close to the bottom; the control valve is a one-way check valve, and the bottom of the outer-layer bottle body is provided with a one-way air inlet valve. This device of dosing can realize the individuation dose of dosing that clinician made, reaches accurate medical purpose, provides more accurate drug therapy scheme for the patient.

Description

Accurate device of dosing of eye

Technical Field

The invention relates to the technical field of medical and health packaging, in particular to a device for accurately administering medicine to eyes of a patient.

Background

The national health committee organization of 2019 formulates and issues a technical guide suitable for preventing and controlling myopia of children and teenagers, and the guide clearly illustrates a scientific diagnosis and treatment and myopia correction method: "myopia children and teenagers, when using low concentration atropine or wearing cornea shaping mirror (OK mirror) to slow down myopia progression, suggest to the regular medical institution, under the guidance of doctor, according to the doctor's advice. The atropine is used as the only myopia prevention and control medicine, and a plurality of problems also exist in the clinical application process: the stability problem of atropine medicaments, individual administration schemes of children in different regions and toxic and side effects caused by long-term application of atropine. The occurrence of toxic and side effects is irrelevant to long-term overdose, so the problem of eye administration which is urgently needed to be solved in clinical application is to accurately control the administration dosage and reduce the overdose.

Meanwhile, the implementation of precise medical plans also means the arrival of a precise development and use medicine age. The development and use of drugs, if not for every individual, also needs to be precisely performed for at least the crowd. Therefore, in order to further solve the serious social public health problem of myopia prevention and control in China, the aim of 'tailor-and-wear' precise drug treatment is achieved for realizing individual drug administration schemes of children in different regions, the development of a precise eye drug administration device becomes a key of a core technology, and meanwhile, the possibility is provided for realizing precise treatment of eye diseases.

Disclosure of Invention

The invention aims to provide an accurate drug delivery device for eyes. This device of dosing can realize the individuation dose of dosing that clinician made, reaches accurate medical purpose, provides more accurate drug therapy scheme for the patient.

In order to achieve the purpose, the invention provides an accurate eye drug delivery device, which comprises a flexible bottle body, an inner plug and an outer cover, wherein the inner plug and the outer cover are arranged on the bottle body; the inner plug comprises a liquid outlet, a medicine storage cavity, a control valve and a liquid conveying pipe, the medicine storage cavity is formed between the control valve and the liquid outlet, one end of the liquid conveying pipe is communicated with the control valve, and the other end of the liquid conveying pipe is inserted into the inner cavity of the inner-layer bottle body and extends to a position close to the bottom; the control valve is a one-way check valve, and the bottom of the outer-layer bottle body is provided with a one-way air inlet valve.

Preferably, the hardness of the inner layer bottle body is less than that of the outer layer bottle body; and/or the thickness of the inner layer bottle body is smaller than that of the outer layer bottle body.

Preferably, a medicine transition cavity is formed between one end of the infusion tube and the control valve, and the volume of the medicine transition cavity is smaller than that of the medicine storage cavity.

Preferably, the upper end of the medicine storage cavity is in a tapered shape with a small top and a large bottom, and the inner cavity of the liquid outlet is in an inverted tapered shape with a large top and a small bottom.

Preferably, the outer cover is an anti-theft outer cover with anti-theft teeth inside, and the inner top of the outer cover is provided with a protrusion which can be matched with the liquid outlet of the inner plug.

Preferably, the one-way check valve comprises a diaphragm-type check valve, a plastic spring check valve or a duckbill-type check valve.

Preferably, the medicine storage chamber has a square, rectangular or spherical shape capable of storing the medicine in a fluid, liquid or mixed composition thereof.

Preferably, the distance between one end of the infusion tube inserted into the inner layer bottle body and the bottom of the inner layer bottle body ranges from 1.0mm to 5.0mm, and preferably ranges from 1.5mm to 2.0 mm.

Preferably, the volume of the medicament storage chamber is in the range 1ul to 100ul, preferably 10ul to 20 ul.

Preferably, the outer layer bottle body is made of PE, PP or PET, and the inner layer bottle body is made of PE; the inner plug and the outer cover are made of one or more of PE, PP and PET; the control valve is made of one or more of silica gel, PE, PP and PVDF; the infusion tube is made of PE, PP or HDPE.

The inner plug of the accurate eye drug delivery device provided by the invention is provided with the drug storage cavity and the one-way check valve, a fixed amount of liquid drug can be extruded into the drug storage cavity by pressing the bottle body, a patient turns the bottle body upside down, and when the bottle body is pressed again, the liquid drug in the drug storage cavity can be dropped into the eye. Because the capacity of medicine storage chamber is specific design, the medicine storage chamber through different capacities controls the dripping dose of eye drops, can reach the purpose of accurate medication, not only can provide more accurate medication scheme for the patient, also helps promoting the more quick development of accurate medication.

Drawings

Fig. 1 is a schematic structural diagram of an accurate eye drug delivery device according to an embodiment of the present invention;

FIG. 2 is an exploded view of the precision ophthalmic drug delivery device of FIG. 1;

FIG. 3 is a schematic view showing the introduction of the liquid medicine into the medicine storage chamber by squeezing the bottle body;

FIG. 4 is a schematic view of the medical fluid after entering the drug storage chamber;

FIG. 5 is a schematic view of inverting the vial and pressing the vial again to administer the drug;

FIG. 6 is a schematic representation of the end of dosing;

FIG. 7 is a schematic view of the open state of the one-way check valve;

fig. 8 is a schematic view of the closed state of the one-way check valve.

In the figure:

1. outer cover 2, inner plug 3, bottle body 31, outer layer bottle body 32, inner layer bottle body 4, protrusion 5, liquid outlet 6, medicine storage cavity 7, control valve 8, infusion tube 9, one-way air inlet valve 10 and medicine transition cavity

Detailed Description

In order that those skilled in the art will better understand the disclosure, the invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

In this specification, terms such as "upper, lower, left, right" and the like are established based on positional relationships shown in the drawings, and depending on the drawings, the corresponding positional relationships may vary, and the direction defined by the characters is preferentially adopted in the direction defined by the characters in the specification, and therefore, the scope of protection is not absolutely limited; moreover, relational terms such as "first" and "second," and the like, may be used solely to distinguish one element from another element having the same name, without necessarily requiring or implying any actual such relationship or order between such elements.

Referring to fig. 1 and fig. 2, fig. 1 is a schematic structural diagram of an accurate eye drug delivery device according to an embodiment of the present invention; fig. 2 is an exploded view of the precision ophthalmic drug delivery device of fig. 1.

As shown in the drawings, in one embodiment, the present invention provides an accurate eye administration device, which mainly comprises three major parts, namely a bottle body 3, an inner plug 2 and an outer cover 1, wherein the bottle body 3 is tightly connected with the outer cover 1 to form a sterile closed system, the bottle body 3 is a flexible bottle body for realizing individual eye administration operation by squeezing, the inner plug 2 realizes quantitative output of administration dosage, and the outer cover 1 is used for sealing the administration device to realize long-term storage.

Specifically, the bottle body 3 is a double-layered bottle body including an outer-layer bottle body 31 and an inner-layer bottle body 32, the outer-layer bottle body 32 has a distance between the outer circumferential portion and the bottom thereof and the inner circumferential portion and the bottom thereof of the outer-layer bottle body 31, the outer-layer bottle body 31 may be made of PE (polyethylene), PP (polypropylene), or PET (polyethylene terephthalate), and the inner-layer bottle body 32 may be made of PE (polyethylene).

Since the inner bottle 32 is not restored after deformation, the hardness of the inner bottle 32 should be less than that of the outer bottle 31, and under the condition that the materials of the outer bottle 31 and the inner bottle 32 are the same, in order to ensure that the hardness of the inner bottle 32 should be less than that of the outer bottle 31, the thickness of the inner bottle 32 should be less than that of the outer bottle 31, and if the materials of the outer bottle 31 and the inner bottle 32 are different and the softness of the material of the inner bottle 32 is less than that of the material of the outer bottle 31, the thicknesses of the inner bottle 32 and the outer bottle 31 can be equal.

The inner plug 2 is provided with a liquid outlet 5, a medicine storage cavity 6, a control valve 7 and an infusion tube 8 from top to bottom, the medicine storage cavity 6 is formed between the control valve 7 and the liquid outlet 5 and used for storing medicines, the shape of the medicine storage cavity is cube, cuboid or spherical, the state of the medicine storage cavity is fluid, liquid or mixed components of the fluid and the liquid, the volume range of the medicine storage cavity 6 is 1ul-100ul, the medicine storage cavity can be adjusted according to different administration requirements, and the human product is preferably 10ul-20ul, so that the accurate output of liquid medicine is achieved.

One end of the infusion tube 8 leads to the control valve 7, and the other end is inserted into the inner cavity of the inner bottle body 32 and extends to a position close to the bottom for delivering the liquid medicine. The infusion tube 8 is made of PE, PP or HDPE (high density polyethylene), the distance between one end of the infusion tube inserted into the inner-layer bottle 32 and the bottom of the inner-layer bottle 32 is 1.0mm-5.0mm, preferably 1.5mm-2.0mm, the distance can ensure that the liquid medicine is completely taken out, waste is avoided, and meanwhile, when the bottle is inverted for administration, the inner port of the infusion tube 8 can be ensured to be above the liquid level of the liquid medicine from the beginning.

The control valve 7 is a one-way check valve for preventing the liquid medicine entering the medicine storage chamber 6 from flowing back to the bottle body, and the bottom of the outer-layer bottle body 31 is provided with a one-way air inlet valve 9 for supplying air after the bottle body is loosened, so that the outer-layer bottle body 31 can restore to the original shape.

The control valve 7 includes, but is not limited to, a diaphragm type check valve, a plastic spring check valve, and a duckbill type check valve, and in this embodiment, the diaphragm type check valve is adopted, and the material of the diaphragm type check valve is one or more of silica gel, PE, PP, and PVDF (polyvinylidene fluoride).

Taking the diaphragm type check valve as an example, the main body part of the diaphragm type check valve is a die sheet divided into a cross shape, when pressure is applied to one direction, the four-piece diaphragm is opened to the other direction to form a passage through which liquid medicine can flow (see fig. 7), and when pressure is applied to the other direction, the four-piece diaphragm is restored to a closed state, and the liquid medicine cannot reversely pass (see fig. 8).

In this embodiment, the outer cap 1 is an anti-theft outer cap having anti-theft teeth therein, and the protrusion 4 is disposed at the top end of the outer cap, and the protrusion 4 is engaged with the liquid outlet 5 of the inner plug 2, so as to prevent the liquid medicine from flowing out and prevent the contaminants from entering.

Be formed with medicine transition chamber 10 between 8's of transfer line one end and the control valve 7, the volume of medicine transition chamber 10 is less than the volume that the medicine stored chamber 6, when the extrusion bottle, the liquid medicine gets into medicine transition chamber 10 from 8's one end earlier, then get into medicine storage chamber 6 from medicine transition chamber 10 again, control valve 7 transversely sets up between medicine transition chamber 10 and medicine storage chamber 6, store chamber 6 with medicine transition chamber 10 and medicine and part, such structure, be favorable to the installation and form the control valve, for example, diaphragm type check valve can with interior stopper 2 integrated into one piece.

The upper end of the medicine storage cavity 6 is in a tapered shape with a small top and a large bottom, the shape is favorable for completely discharging the liquid medicine, the inner cavity of the liquid outlet 5 is in an inverted cone shape with a large top and a small bottom, the shape is matched with the shape of the medicine storage cavity 6, the liquid medicine can form ideal liquid drops, and therefore the comfort of medicine taking of a patient is improved.

Referring to fig. 3 to 6 together, fig. 3 is a schematic view illustrating a liquid medicine is introduced into a medicine storage chamber by squeezing a bottle body; FIG. 4 is a schematic view of the medical fluid after entering the drug storage chamber; FIG. 5 is a schematic view of inverting the vial and pressing the vial again to administer the drug; FIG. 6 is a schematic view after completion of administration.

As shown in the figure, when the medical liquid infusion device is used, a patient presses the outer-layer bottle body 31, the control valve 7 is opened, the medical liquid enters the medicine storage cavity 6 through the infusion tube 8, after the pressing is stopped, the control valve 7 is closed to prevent the medical liquid from flowing back, then the bottle body is inverted, the outer-layer bottle body 31 is pressed again, and the medical liquid in the medicine storage cavity 6 is dropped into eyes. Because the capacity of the medicine storage cavity 6 is specially designed, the dripping dosage of the eye drops is controlled by the medicine storage cavities 6 with different capacities, thereby achieving the purpose of precise medicine treatment.

In the use, because the insertion end of transfer line 8 is higher than the liquid medicine liquid level in the bottle, can not have new liquid medicine entering medicine storage chamber 6, after loosening the bottle, the space tonifying qi between outside air accessible bottom of the bottle one-way admission valve 9 to outer layer bottle 31 and the inlayer bottle 32, make outer layer bottle 31 resume original shape, so that use next time, simultaneously, inlayer bottle 32 keeps the shape after being extrudeed, do not resume original shape, avoid inhaling the air, thereby effectively prevent the air backward flow, reduce the liquid medicine by the risk of microbial contamination in the air.

The above embodiments are merely preferred embodiments of the present invention, and are not limited thereto, and on the basis of the above embodiments, various embodiments can be obtained by performing targeted adjustment according to actual needs. For example, the material of the inner plug 2 and the outer cover 1 is one or more of PE, PP and PET, or the medicine transition cavity 10 is eliminated, and the like. This is not illustrated here, since many implementations are possible.

The inner plug 2 of the accurate eye drug delivery device provided by the invention is provided with the drug storage cavity 6 and the control valve 7, wherein the capacity of the drug storage cavity 6 is specially designed, and the dropping dosage of eye drops can be controlled through the drug storage cavities 6 with different capacities, so that the purpose of accurate drug treatment is achieved, a more accurate drug treatment scheme can be provided for patients, and the rapid development of accurate drug treatment is promoted.

The precise ocular drug delivery device provided by the invention is described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the core concepts of the present invention. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.

Claims

1. An accurate eye drug delivery device comprises a flexible bottle body, an inner plug and an outer cover, wherein the inner plug and the outer cover are arranged on the bottle body; the inner plug comprises a liquid outlet, a medicine storage cavity, a control valve and a liquid conveying pipe, the medicine storage cavity is formed between the control valve and the liquid outlet, one end of the liquid conveying pipe is communicated with the control valve, and the other end of the liquid conveying pipe is inserted into the inner cavity of the inner-layer bottle body and extends to a position close to the bottom; the control valve is a one-way check valve, and the bottom of the outer-layer bottle body is provided with a one-way air inlet valve.

2. The device for accurate ocular administration of claim 1, wherein the inner vial has a hardness less than the hardness of the outer vial; and/or the thickness of the inner layer bottle body is smaller than that of the outer layer bottle body.

3. The device for precise dosing of an eye according to claim 1, wherein a drug transition chamber is formed between one end of the infusion tube and the control valve, and the volume of the drug transition chamber is smaller than the volume of the drug storage chamber.

4. The device for precise delivery of medication to the eye of claim 1, wherein the upper end of the medication storage chamber is tapered with a smaller top and a larger bottom, and the inner cavity of the medication outlet is inverted tapered with a larger top and a smaller bottom.

5. The device for precise delivery of drugs to the eye according to claim 1, wherein the outer cap is an anti-theft outer cap with anti-theft teeth inside, and the inner top of the outer cap is provided with a protrusion capable of matching with the liquid outlet of the inner plug.

6. The ophthalmic precision drug delivery device of claim 1, wherein the one-way check valve comprises a diaphragm-type check valve, a plastic spring check valve, or a duckbill-type check valve.

7. The device for accurate ocular administration of claim 1, wherein the drug storage chamber has a shape of a cube, a cuboid or a sphere capable of storing the drug in a fluid, a liquid or a mixed composition thereof.

8. The accurate ocular drug delivery device according to claim 1, wherein the distance between the end of the infusion tube inserted into the inner bottle and the bottom of the inner bottle is in the range of 1.0mm to 5.0mm, preferably 1.5mm to 2.0 mm.

9. An accurate ocular drug delivery device as in claim 1, wherein the volume of the drug storage chamber is in the range of 1ul to 100ul, preferably 10ul to 20 ul.

10. The accurate ocular drug delivery device of claim 1, wherein the material of the outer layer bottle is PE, PP or PET, and the material of the inner layer bottle is PE; the inner plug and the outer cover are made of one or more of PE, PP and PET; the control valve is made of one or more of silica gel, PE, PP and PVDF; the infusion tube is made of PE, PP or HDPE.