CN101999956B - Implantable intraocular quantitative medicine injection pump - Google Patents
Implantable intraocular quantitative medicine injection pump Download PDFInfo
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- CN101999956B CN101999956B CN2010105455024A CN201010545502A CN101999956B CN 101999956 B CN101999956 B CN 101999956B CN 2010105455024 A CN2010105455024 A CN 2010105455024A CN 201010545502 A CN201010545502 A CN 201010545502A CN 101999956 B CN101999956 B CN 101999956B
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Abstract
The invention discloses an implantable intraocular quantitative medicine injection pump which comprises a medicine guiding pipe and a medicine adding bag, wherein a medicine inlet and a medicine outlet are arranged on the medicine adding bag, and one end of the medicine guiding pipe is communicated with the medicine outlet. While in use, the medicine adding bag is filled with medicine liquid and is punctured at the cornea segment, the medicine guiding pipe is inserted, the medicine adding bag is extruded, and the medicine liquid flows into the vitreous body through the medicine guiding pipe. The capacity of the medicine adding bag can be designed into a quantity required for single medication, an operator does not require repeating measuring medicine quantity during each medication, and the working efficiency is increased. The device can quantitatively medicate the eye posterior segment for multiple times without intraocular operation, is safe for implantation and easy for taking out, can reduce intraocular infection risk, can realize long-term sustainable medication to form effective medicine concentration and can enhance the local curative effects of the medicine in the eyes. The purpose of treating a series of intractable eye diseases requiring overall or local frequent medication is achieved, and the invention has great economical and social benefits and is very applicable to clinic application.
Description
Technical field
The present invention relates to a kind of and use medical treatment device, the quantitative killer injecting pump of particularly a kind of implanted ophthalmic.
Background technology
Because the complicacy of ocular physiology structure and the influence of blood-eye barrier, the effect of many Drug therapy eye posterior segment disease is very little.
At present, the medicine injection mode of traditional eye posterior segment disease roughly has systemic fashion and local mode.Systemic fashion is the intravenous injection mode, and the waiting time of its contact process is long, and medicine is easily by cytophagy, and Loss Rate is high, is difficult to reach active drug concentration, to the health toxic side effect, and increases the patient medical cost burden.Local mode comprises that eye is with drop, intravitreal injection and intraocularly embedded device.Eye is with the effect of drop owing to the cornea barrier, and an eye back segment is difficult to reach effective drug level; The vitreous body intracavitary administration can make medicine directly arrive a back segment; But medicine is shorter in the intravitreous half-life; Need repeatedly many these injections just can reach therapeutic purposes; Cause easily infecting, a series of complication such as hemorrhage, detachment of retina, have administration inconvenience and cause the risk of serious side effects; Also have delayed release device, in vitreous body, put into, need intraocular surgery, possibly damage the eyeball interior tissue.Eye special anatomical feature limits the clinical practice of many dosing eyes dosage forms, a kind of route of administration safely and effectively is very important to treatment eye posterior segment disease.
Provide a kind of need not intraocular surgery also can be quantitatively repeatedly to the new device of eye back segment administration; Can avoid the shortcoming of above-mentioned several kinds of administering modes; Can realize the long-term active drug concentration that continues, strengthen medicine local curative effect within the eye, reduce toxic and side effects, improve therapeutic effect and safe in utilization; Reach the purpose of the intractable oculopathy of treatment long-term whole body of a series of need or local frequent medication, significance is arranged.
Summary of the invention
In view of this; The purpose of this invention is to provide the quantitative killer injecting pump of a kind of implanted ophthalmic, need not intraocular surgery and also can medicine can be reached in vivo continue for a long time more stable valid density quantitatively repeatedly to the administration of eye back segment; And reduction toxic and side effects; Improve therapeutic effect and drug safety, easy to use, implant safety and take out easily.
The objective of the invention is to realize through following technical scheme: the quantitative killer injecting pump of a kind of implanted ophthalmic comprises medicine-introducing pipe and adds medicine bag that add feeding opening and medicine outlet are set on the medicine bag, an end of medicine-introducing pipe is communicated with medicine outlet.
Further, said medicine outlet place is provided with the check valve I that can open to the medicine-introducing pipe direction;
Further, said check valve I comprises valve gap and the spring that is used to open and close medicine outlet, and said medicine-introducing pipe inwall has been disposed radially boss, and spring is positioned at medicine-introducing pipe and an end withstands boss, and the other end is fixedly connected with valve gap;
Further, also comprise the medicine storing bag that is communicated with the feeding opening that adds medicine bag, the feeding opening place is provided with and can dosing mouth be set on the medicine storing bag to adding the check valve II that the medicine bag direction is opened;
Further, said check valve II comprises the one-way membrane of being processed by elastomeric material, and one-way membrane one end is fixedly connected with the cyst wall that adds medicine bag or medicine storing bag, and free end extends on the dosing capsule inner wall, and under the effect of self elastic force, fits with the sealing of dosing capsule inner wall;
Further, the part of said one-way membrane and dosing capsule inner wall sealing applying is provided with medicine feeding hole;
Further, said medicine-introducing pipe internal diameter of tube body is 0.3-0.5mm, body wall thickness 0.1-0.3mm, and body length is 9-11mm, and adding the medicine bag capacity is 0.05-0.2ml, and the medicine storing bag capacity is 0.5-2ml;
Further; The said medicine bag, medicine storing bag, valve gap, one-way membrane of adding processed by medical addition type polysiloxane elastomeric material; Add medicine bag along feeding opening circumferentially and medicine storing bag be fixedly connected to form one, the medicine storing bag bottom surface is the arc of concave end on the medicine storing bag, the arc central angle is 68 °.
Beneficial effect of the present invention: the quantitative killer injecting pump of implanted ophthalmic of the present invention comprises medicine-introducing pipe and adds medicine bag that add feeding opening and medicine outlet are set on the medicine bag, an end of medicine-introducing pipe is communicated with medicine outlet; During use, 4mm position after corneal section (being orbiculus ciliaris) puncture, medicine-introducing pipe is inserted vitreous chamber, in adding medicine bag, be full of medicinal liquid after; Through sealings such as stoppers, extruding adds medicine bag with feeding opening, and pharmaceutical liquid flows to vitreous body through medicine-introducing pipe, adds the size that the medicine bag capacity can be designed to the single-dose aequum; Make the operator needn't be again when each administration the repeated measure dosage, increase work efficiency, single-dose fully after; Close the check valve I, open feeding opening, add the medicine bag expansion and reply initial conditions; Use up when adding the medicine bag herb liquid, can replenish medicinal liquid, be convenient to carry out next administration through feeding opening; The present invention makes simply, and is with low cost, easy to use; Need not intraocular surgery and also can implant safety, take out easily, reduce the intraocular infection risk quantitatively repeatedly to the administration of eye back segment; Be used for a posterior segment disease treatment and can realize the fixed quantity administration, form the drug level of long-term continuous and effective, strengthen medicine local curative effect within the eye; Reach the purpose of the intractable oculopathy of treatment long-term whole body of a series of need or local frequent medication, have great economic and social benefit, be fit to very much clinical practice.
Description of drawings
Below in conjunction with accompanying drawing and specific embodiment the present invention is further described:
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the A portion enlarged drawing among Fig. 1;
Fig. 3 is the B portion enlarged drawing among Fig. 1.
The specific embodiment
Fig. 1 is a structural representation of the present invention; Fig. 2 is the A portion enlarged drawing among Fig. 1; Fig. 3 is the B portion enlarged drawing among Fig. 1.As shown in the figure: the quantitative killer injecting pump of implanted ophthalmic of present embodiment comprises medicine-introducing pipe 1 and adds medicine bag 2 that add feeding opening 21 and medicine outlet 22 are set on the medicine bag, an end of medicine-introducing pipe is communicated with medicine outlet; During use, will add medicine bag and be full of medicinal liquid, through the sealing of parts such as stopper, puncture and medicine-introducing pipe filled in the 4mm position after corneal section again with feeding opening; Extruding adds medicine bag, and pharmaceutical liquid flows to vitreous body through medicine-introducing pipe, adds the size that the medicine bag capacity can be designed to the single-dose aequum; Realize the medicine calibrated shot, the operator needn't be again when each administration the repeated measure dosage, increase work efficiency; After single-dose is accomplished, open feeding opening and fill it up with medicinal liquid once again, add the medicine bag expansion and reply initial conditions; Be convenient to carry out next administration, simple in structure, easy to use.
In the present invention, as further improvement, said medicine outlet 22 places are provided with the check valve I that can open to the medicine-introducing pipe direction; In the present embodiment, said check valve I comprises the valve gap 3 and spring 4 that is used to open and close medicine outlet, and said medicine-introducing pipe inwall has been disposed radially boss 5, and spring is positioned at medicine-introducing pipe and an end withstands boss, and the other end is fixedly connected with valve gap; When extruding adds medicine bag, under the fluid pressure effect, valve gap is pushed away medicine outlet, and spring is compressed; Medicinal liquid flows out from the space between valve gap and the medicine-introducing pipe inwall, and when medicinal liquid flows to end, pressure disappears; Spring resets, and valve gap is placed on the medicine outlet again, realizes the automatic sealing of medicine outlet.
As the further improvement of previous embodiment, also comprise the medicine storing bag 6 that is communicated with the feeding opening that adds medicine bag, feeding opening 21 places are provided with and can dosing mouth 61 be set on the medicine storing bag to adding the check valve II that the medicine bag direction is opened, and the said medicine bag 2 of adding is processed by elastomeric material; In the present embodiment, said check valve II comprises the one-way membrane of being processed by elastomeric material 7, and one-way membrane one end is fixedly connected with the cyst wall that adds medicine bag or medicine storing bag, and free end extends on the dosing capsule inner wall, and under the effect of self elastic force, fits with the sealing of dosing capsule inner wall; During use,, all inject ophthalmic, stop to push and add medicine bag when adding the medicine bag medicinal liquid to the medicine storing bag subsequent use medicinal liquid of packing into; Add and be the negative pressure attitude in the medicine bag, under the spring thrust effect, valve gap is placed on the medicine outlet 22 again, because of adding in the medicine bag pressure less than pressure in the medicine storing bag; Under the effect of medicine storing bag fluid pressure, one-way membrane 7 is opened towards adding the medicine bag direction, and the subsequent use medicinal liquid that is arranged in medicine storing bag flows into automatically and adds medicine bag; When add medicine bag storage full after, unidirectional diaphragm is closed, and realizes adding replenishing automatically of medicine bag herb liquid; Easy and simple to handle, high efficiency reduces the possibility of liquid medicine contamination simultaneously.
As the further improvement of previous embodiment, said one-way membrane 7 is provided with medicine feeding hole 71 with the part that the sealing of dosing capsule inner wall is fitted, and the setting of medicine feeding hole 71 more helps medicinal liquid and adds medicine bag through medicine feeding hole from the medicine storing bag inflow.
As the further improvement of previous embodiment, said medicine-introducing pipe 1 internal diameter of tube body is 0.3-0.5mm, body wall thickness 0.1-0.3mm; Body length is 9-11mm, and adding the medicine bag capacity is 0.05-0.2ml, and the medicine storing bag capacity is 0.5-2ml; The specific embodiment is: internal diameter of tube body is 0.4mm, body wall thickness 0.2mm, and body length is 10mm; Adding the medicine bag capacity is 0.05ml, and the medicine storing bag capacity is 0.5ml, in conjunction with clinical trial; The quantitative killer injecting pump of implanted ophthalmic of above-mentioned parameter, operating characteristics is better, and practicality is higher.
As the further improvement of previous embodiment, the said medicine bag 2, medicine storing bag 6, valve gap 3, one-way membrane 7 of adding processed by medical addition type polysiloxane elastomeric material, verified to have the good tissue biocompatibility; Add medicine bag 2 sidewalls and circumferentially be fixedly connected to form one, be convenient to process with medicine storing bag 6 along feeding opening 21, with low cost; The medicine storing bag bottom surface is towards the arc that adds medicine bag top depression; The arc central angle is 68 °, and being convenient to it can close with the eye Surface Mount, and comfort is strong.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of technical scheme of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (6)
1. quantitative killer injecting pump of implanted ophthalmic is characterized in that: comprise medicine-introducing pipe (1) and add medicine bag (2) that add feeding opening (21) and medicine outlet (22) are set on the medicine bag, an end of medicine-introducing pipe is communicated with medicine outlet; Said medicine outlet (22) locates to be provided with the check valve I that can open to the medicine-introducing pipe direction; Said check valve I comprises valve gap (3) and the spring (4) that is used to open and close medicine outlet; Said medicine-introducing pipe inwall has been disposed radially boss (5); Spring is positioned at medicine-introducing pipe and an end withstands boss, and the other end is fixedly connected with valve gap.
2. the quantitative killer injecting pump of implanted ophthalmic according to claim 1; It is characterized in that: also comprise the medicine storing bag (6) that is communicated with the feeding opening that adds medicine bag; Feeding opening (21) is located to be provided with can be to adding the check valve II that the medicine bag direction is opened; Dosing mouth (61) is set on the medicine storing bag, and the said medicine bag (2) that adds is processed by elastomeric material.
3. the quantitative killer injecting pump of implanted ophthalmic according to claim 2; It is characterized in that: said check valve II comprises the one-way membrane of being processed by elastomeric material (7); One-way membrane one end is fixedly connected with the cyst wall that adds medicine bag or medicine storing bag; Free end extends on the dosing capsule inner wall, and under the effect of self elastic force, fits with the sealing of dosing capsule inner wall.
4. the quantitative killer injecting pump of implanted ophthalmic according to claim 3 is characterized in that: said one-way membrane (7) is provided with medicine feeding hole (71) with the part that the sealing of dosing capsule inner wall is fitted.
5. the quantitative killer injecting pump of implanted ophthalmic according to claim 4; It is characterized in that: said medicine-introducing pipe (1) internal diameter of tube body is 0.3-0.5mm, body wall thickness 0.1-0.3mm, and body length is 9-11mm; Adding the medicine bag capacity is 0.05-0.2ml, and the medicine storing bag capacity is 0.5-2ml.
6. the quantitative killer injecting pump of implanted ophthalmic according to claim 5; It is characterized in that: the said medicine bag (2), medicine storing bag (6), valve gap (3), one-way membrane (7) of adding processed by medical addition type polysiloxane elastomeric material; Add medicine bag (2) along feeding opening (21) circumferentially and medicine storing bag (6) be fixedly connected to form one; Medicine storing bag (6) bottom surface is the arc of concave end on the medicine storing bag, and the arc central angle is 68 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105455024A CN101999956B (en) | 2010-11-16 | 2010-11-16 | Implantable intraocular quantitative medicine injection pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105455024A CN101999956B (en) | 2010-11-16 | 2010-11-16 | Implantable intraocular quantitative medicine injection pump |
Publications (2)
| Publication Number | Publication Date |
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| CN101999956A CN101999956A (en) | 2011-04-06 |
| CN101999956B true CN101999956B (en) | 2012-07-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105455024A Expired - Fee Related CN101999956B (en) | 2010-11-16 | 2010-11-16 | Implantable intraocular quantitative medicine injection pump |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102963603A (en) * | 2012-12-08 | 2013-03-13 | 胡成佐 | Packaging box |
| CN104759023A (en) * | 2015-04-08 | 2015-07-08 | 四川大学华西医院 | In-vivo medicine delivery device capable of refilling medicine |
| CN107335128A (en) * | 2016-10-29 | 2017-11-10 | 宋宜德 | The anal canal can be oriented to, be administered, cleaned |
| CN107961420B (en) * | 2016-12-02 | 2022-04-29 | 北京纳米能源与系统研究所 | Self-driven medicine injection device and injection method |
| CN110236780B (en) * | 2019-07-08 | 2020-05-22 | 温州医科大学附属眼视光医院 | Control system for corneal cross-linking drug administration treatment assistance |
| CN113081167B (en) * | 2021-05-13 | 2022-07-29 | 南阳市中心医院 | A guiding device for sacculus is dissolved and is tied for department of neurology |
| CN115430026A (en) * | 2022-09-23 | 2022-12-06 | 南京鼓楼医院 | Integrated artificial cochlea implant repeated delivery dosing electrode and control device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2297183Y (en) * | 1997-06-25 | 1998-11-18 | 张秀安 | Disposable drug contactor for eyes |
| CN200977282Y (en) * | 2006-10-10 | 2007-11-21 | 吴广印 | Eye drops liquid spraying bottle |
| CN201154029Y (en) * | 2008-02-20 | 2008-11-26 | 赵军 | Eye ointment administration device |
-
2010
- 2010-11-16 CN CN2010105455024A patent/CN101999956B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2297183Y (en) * | 1997-06-25 | 1998-11-18 | 张秀安 | Disposable drug contactor for eyes |
| CN200977282Y (en) * | 2006-10-10 | 2007-11-21 | 吴广印 | Eye drops liquid spraying bottle |
| CN201154029Y (en) * | 2008-02-20 | 2008-11-26 | 赵军 | Eye ointment administration device |
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| Publication number | Publication date |
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| CN101999956A (en) | 2011-04-06 |
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| C14 | Grant of patent or utility model | ||
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| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Peng Yanli Inventor after: Wang Yi Inventor after: Wu Nan Inventor before: Peng Yanli Inventor before: Wang Yi |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: PENG YANLI WANG YI TO: PENG YANLI WANG YI WU NAN |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120725 Termination date: 20171116 |
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| CF01 | Termination of patent right due to non-payment of annual fee |