CN113383007A - Caix特异性的双环肽配体 - Google Patents

Caix特异性的双环肽配体 Download PDF

Info

Publication number
CN113383007A
CN113383007A CN202080009043.XA CN202080009043A CN113383007A CN 113383007 A CN113383007 A CN 113383007A CN 202080009043 A CN202080009043 A CN 202080009043A CN 113383007 A CN113383007 A CN 113383007A
Authority
CN
China
Prior art keywords
seq
referred
iii
peptide ligand
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080009043.XA
Other languages
English (en)
Chinese (zh)
Inventor
L·巴尔达萨雷
L·陈
R·拉尼
C·斯泰斯
D·托伊费尔
E·沃克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BicycleTx Ltd
Original Assignee
BicycleTx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of CN113383007A publication Critical patent/CN113383007A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01001—Carbonate dehydratase (4.2.1.1), i.e. carbonic anhydrase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN202080009043.XA 2019-01-15 2020-01-15 Caix特异性的双环肽配体 Pending CN113383007A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1900525.5A GB201900525D0 (en) 2019-01-15 2019-01-15 Bicyclic peptide ligands specific for caix
GB1900525.5 2019-01-15
PCT/GB2020/050069 WO2020148525A1 (en) 2019-01-15 2020-01-15 Bicyclic peptide ligands specific for caix

Publications (1)

Publication Number Publication Date
CN113383007A true CN113383007A (zh) 2021-09-10

Family

ID=65528179

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080009043.XA Pending CN113383007A (zh) 2019-01-15 2020-01-15 Caix特异性的双环肽配体

Country Status (6)

Country Link
US (1) US20220088118A1 (https=)
EP (1) EP3911665A1 (https=)
JP (1) JP2022518695A (https=)
CN (1) CN113383007A (https=)
GB (1) GB201900525D0 (https=)
WO (1) WO2020148525A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120230182A (zh) * 2025-05-29 2025-07-01 北京肿瘤医院(北京大学肿瘤医院) 经修饰的caix靶向环肽及其核素标记物与应用

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6882978B2 (ja) 2014-10-29 2021-06-02 バイスクルアールディー・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
JP7301757B2 (ja) 2017-06-26 2023-07-03 バイスクルアールディー・リミテッド 検出可能部分を持つ二環式ペプチドリガンドおよびその使用
CN111183147B (zh) 2017-08-04 2024-07-05 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
US12551567B2 (en) 2018-12-21 2026-02-17 Bicyclerd Limited Bicyclic peptide ligands specific for PD-L1
JP2022514618A (ja) 2018-12-21 2022-02-14 バイスクルテクス・リミテッド Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
IL300248A (en) 2020-08-03 2023-03-01 Bicycletx Ltd peptide-based linkers
US20250339569A1 (en) * 2021-12-17 2025-11-06 3B Pharmaceuticals Gmbh Carbonic anhydrase ix ligands
CN118852348A (zh) * 2022-02-11 2024-10-29 C-比奥麦克斯有限公司 靶向碳酸酐酶ix的肽配体、包含其的肽结构体及它们的用途
KR20250170626A (ko) * 2023-07-25 2025-12-05 (주)씨바이오멕스 탄산탈수소효소 ⅸ를 표적으로 하는 펩타이드 구조체 및 이들의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018197893A1 (en) * 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof
US20180371020A1 (en) * 2017-06-26 2018-12-27 Bicyclerd Limited Bicyclic peptide ligands with detectable moieties and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009211253B2 (en) 2008-02-05 2014-11-06 Bicyclerd Limited Methods and compositions
JP6882978B2 (ja) 2014-10-29 2021-06-02 バイスクルアールディー・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018197893A1 (en) * 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof
US20180371020A1 (en) * 2017-06-26 2018-12-27 Bicyclerd Limited Bicyclic peptide ligands with detectable moieties and uses thereof
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEN, 等: "Peptide Ligands Stabilized by Small Molecules", 《ANGEW CHEM INT ED ENGL》, vol. 53, no. 6, 3 February 2014 (2014-02-03), pages 1602 - 1606, XP055356354, DOI: 10.1002/anie.201309459 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120230182A (zh) * 2025-05-29 2025-07-01 北京肿瘤医院(北京大学肿瘤医院) 经修饰的caix靶向环肽及其核素标记物与应用

Also Published As

Publication number Publication date
WO2020148525A1 (en) 2020-07-23
JP2022518695A (ja) 2022-03-16
GB201900525D0 (en) 2019-03-06
US20220088118A1 (en) 2022-03-24
EP3911665A1 (en) 2021-11-24

Similar Documents

Publication Publication Date Title
CN113383007A (zh) Caix特异性的双环肽配体
JP7620002B2 (ja) ヘテロタンデム二環式ペプチド複合体
CN113383074A (zh) Caix特异性的双环肽配体
EP3727462B1 (en) Bicyclic peptide ligands specific for epha2
CN113507960A (zh) Psma特异性的双环肽配体
CN109414510B (zh) Mt1-mmp特异性双环肽-毒素缀合物
CN113543813B (zh) Cd38特异性的双环肽配体
CN113474045A (zh) Pd-l1特异性的双环肽配体
CN113260420A (zh) Pd-l1特异性的双环肽配体
CN113439088A (zh) 整联蛋白αvβ3特异性的双环肽配体
KR20200105839A (ko) EphA2에 특이적인 바이사이클릭 펩티드 리간드
CN113613728A (zh) 整联蛋白αvβ3特异性的双环肽配体
CN113474047A (zh) Mt1-mmp特异性的双环肽配体
WO2019025811A1 (en) SPECIFIC BICYCLIC PEPTIDE LIGANDS OF CD137
CN113518648A (zh) Mt1-mmp特异性的双环肽配体
CN113474046A (zh) Il-17特异性的双环肽配体
CN113507961A (zh) FAPα特异性的双环肽配体
CN114787177A (zh) Il-17特异性的双环肽配体
CN114829376A (zh) Il-17特异性的双环肽配体
CN114867736A (zh) Il-17特异性的双环肽配体
CN114787176A (zh) Il-17特异性的双环肽配体

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20210910

WD01 Invention patent application deemed withdrawn after publication