CN113376368A - Immunoassay analyzer - Google Patents

Immunoassay analyzer Download PDF

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Publication number
CN113376368A
CN113376368A CN202110805150.XA CN202110805150A CN113376368A CN 113376368 A CN113376368 A CN 113376368A CN 202110805150 A CN202110805150 A CN 202110805150A CN 113376368 A CN113376368 A CN 113376368A
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buffer
partition plate
outlet
module
buffering
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CN202110805150.XA
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CN113376368B (en
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植立才
冯成
刘同民
肖承亮
王治才
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Guangzhou Labsim Biotech Co Ltd
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Guangzhou Labsim Biotech Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • G01N33/5304Reaction vessels, e.g. agglutination plates

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention discloses an immunoassay analyzer, which comprises a feeding module and a buffer module, wherein a buffer inlet of the buffer module is communicated with the feeding module, a partition plate assembly is arranged between the buffer inlet and a buffer outlet, a first partition plate and a second partition plate of the partition plate assembly form a storage area at intervals, the storage area is used for storing materials at the most end part of the buffer module, the first partition plate and the second partition plate can move to alternately block the buffer outlet, when the first partition plate blocks the buffer outlet, the materials close to the buffer outlet in the buffer module enter the storage area, the first partition plate blocks the materials in the storage area from separating from the buffer module, and when the second partition plate blocks the buffer outlet, the materials in the storage area can separate from the buffer module. Through setting up the baffle subassembly, the reaction cup quantity that the single left the buffering export can be controlled to the district of depositing in the baffle subassembly to avoid too much reaction cup to leave the buffering module simultaneously, avoid appearing blocking up the phenomenon in the buffering export.

Description

Immunoassay analyzer
Technical Field
The invention relates to the field of medical instruments, in particular to an immunoassay analyzer.
Background
The full-automatic immunoassay analyzer is an apparatus for immunological quantitative analysis of a body fluid sample of a patient, has the characteristics of high sensitivity, wide linear range, simple apparatus and equipment, convenience in operation, high analysis speed, high inspection automation degree and the like, and improves the immunoassay efficiency. Because the method has the advantages of eliminating artificial subjective errors, stabilizing quality of immunoassay and the like, the method is widely applied to the fields of modern clinical immunoassay diagnosis and life science research at present.
Fully automated immunoassay analyzers generally comprise: the device comprises a reaction cup feeding module, a sample detection module, a reagent detection module and the like. The operator places the vessel, which is previously loaded with the cuvettes, at a designated position, and then transports the cuvettes in the vessel to a predetermined position of each module by the transport means. During the transmission period of the reaction cup, the phenomenon of congestion is easy to occur, so that the transmission is unstable; when the reaction cup is jammed, the operation such as sample detection, reagent detection and the like is not facilitated, the position of the reaction cup needs to be manually adjusted, and the automation degree of the immunoassay analyzer is reduced.
Disclosure of Invention
The embodiment of the invention aims to: provided is an immunoassay analyzer which can stably carry cuvettes and which has a high degree of automation of the operation.
In order to achieve the purpose, the invention adopts the following technical scheme:
providing an immunoassay analyzer, which comprises a feeding module and a buffer module, wherein the buffer module comprises a buffer inlet, a buffer outlet and a partition plate assembly, the buffer inlet is used for being communicated with the feeding module, the partition plate assembly is arranged between the buffer inlet and the buffer outlet, the partition plate assembly comprises a first partition plate and a second partition plate which are arranged at intervals, a storage area is formed between the first partition plate and the second partition plate, the storage area is used for storing materials of the buffer module, which are close to the buffer outlet, the first partition plate and the second partition plate can move to alternately block the buffer outlet, when the first partition plate blocks the buffer outlet, the materials in the buffer module, which are close to the buffer outlet, enter the storage area, and the first partition plate blocks the materials in the storage area from entering the buffer outlet, when the second partition plate blocks the buffer outlet, the materials in the storage area can enter the buffer outlet.
As a preferable mode of the immunoassay analyzer, the partition plate assembly includes a connection plate, and the first partition plate and the second partition plate are connected by the connection plate.
As a preferable scheme of the immunoassay analyzer, the first partition plate and the second partition plate are respectively disposed at two sides of the connecting plate, the connecting plate has a first position and a second position, when the connecting plate is located at the first position, the first partition plate blocks the buffer outlet, and the second partition plate is far away from the buffer outlet; when the connecting plate is located at the second position, the second partition plate blocks the buffer outlet, and the first partition plate is far away from the buffer outlet.
As an optimized scheme of the immunoassay analyzer, the buffering module comprises a receiving slide rail which is obliquely arranged, one end of the receiving slide rail is communicated with the buffering inlet, the other end of the receiving slide rail is provided with the buffering outlet, and the receiving slide rail guides the material from the buffering inlet to the buffering outlet.
As a preferred scheme of the immunoassay analyzer, a first sensor is arranged on the receiving slideway and used for detecting whether the materials exist in the receiving slideway or not.
As a preferred scheme of the immunoassay analyzer, the immunoassay analyzer comprises a detection module, the detection module comprises a first conveyor belt, the first conveyor belt has a first detection end and a second detection end, a detection position is arranged on the first conveyor belt, the detection position is located between the first detection end and the second detection end, a material leaves from the buffer outlet and enters the first conveyor belt from the first detection end, a blocking piece assembly is arranged on the first conveyor belt, and the blocking piece assembly selectively blocks the material on the first conveyor belt from stopping at the detection position.
As an optimized scheme of the immunoassay analyzer, the blocking piece assembly comprises a first blocking piece and a second blocking piece which are arranged at intervals, the first blocking piece is located on one side, close to the first detection end, of the second blocking piece, the first blocking piece and the second blocking piece are both in a blocking state and a communicating state, the first blocking piece is located in the communicating state, the material can be moved to the detection position from the first detection end, and the material can be stopped in the detection position when the second blocking piece is located in the blocking state.
As a preferred embodiment of the immunoassay analyzer,
the first baffle plate is provided with a first body, a first limiting part and a second limiting part which are spaced are arranged on one side of the first body in a protruding mode, and the material is located between the first limiting part and the second limiting part; and/or the presence of a gas in the gas,
the second stopper has a second body, one side protrusion of second body is provided with spacing third spacing portion and spacing fourth portion, the material is located spacing portion of third with between the spacing portion of fourth.
As a preferable scheme of the immunoassay analyzer, the first position-limiting part is located on one side of the second position-limiting part close to the first detection end, and the length of the second position-limiting part is greater than that of the first position-limiting part; and/or the presence of a gas in the gas,
the third limiting part is positioned on one side of the fourth limiting part close to the first detection end, and the length of the fourth limiting part is greater than that of the third limiting part.
As a preferable scheme of the immunoassay analyzer, the first detection end is provided with a second sensor, and the second sensor is used for detecting whether the material is in the first conveying belt or not.
The invention has the beneficial effects that: by arranging the buffer module, the direction of the reaction cups can be adjusted, and disordered reaction cups are orderly separated from the buffer module, so that automatic feeding is realized; through setting up the baffle subassembly, the reaction cup quantity that the single left the buffering export can be controlled to the district of depositing in the baffle subassembly to avoid too much reaction cup to leave the buffering module simultaneously, avoid appearing blocking up the phenomenon in the buffering export.
Drawings
The invention is explained in more detail below with reference to the figures and examples.
Fig. 1 is a schematic view of an immunoassay analyzer according to an embodiment of the present invention.
Fig. 2 is a schematic view of another view of the immunoassay analyzer according to the embodiment of the present invention.
Fig. 3 is a schematic view of a feeding module and a buffer module according to an embodiment of the present invention.
Fig. 4 is a schematic view of a feeding module and a buffer module according to another embodiment of the present invention (a storage bin is not shown).
Fig. 5 is a schematic view of a feeding module and a buffering module according to another embodiment of the present invention (a storage bin is not shown).
Fig. 6 is a partial schematic view of the feeding module according to the embodiment of the present invention.
Fig. 7 is a schematic view of a buffer module according to an embodiment of the invention (the buffer box is not shown).
Fig. 8 is a schematic view of another view of the buffer module according to the embodiment of the present invention (the buffer box is not shown).
FIG. 9 is a schematic view of the receiving chute and baffle assembly of the present invention (with the baffle assembly in a first position).
FIG. 10 is a schematic view of the receiving chute and bulkhead assembly of the present invention (with the bulkhead assembly in the second position).
FIG. 11 is a schematic view of a baffle plate assembly according to an embodiment of the present invention.
Fig. 12 is a schematic diagram of a collection module according to an embodiment of the invention.
Fig. 13 is a schematic view of the first blocking sheet according to the embodiment of the invention.
Fig. 14 is a schematic diagram of a detection module according to an embodiment of the present invention.
In the figure:
100. a feeding module; 200. a buffer module; 300. a detection module; 3001. a flap assembly; 400. a collection module;
1. a storage bin; 101. a first region; 102. a second region; 103. an opening; 104. a partition plate; 2. a second conveyor belt; 201. transmitting the bit; 202. a first feeding end; 203. a second feeding end; 3. a frame; 4. a first motor; 5. a buffer box; 501. a buffer plate; 502. a base plate; 503. a first side wall; 504. a second side wall; 6. a receiving slideway; 601. a receiving end; 7. a transition plate; 8. a bulkhead assembly; 801. a first separator; 802. a second separator; 803. a connecting plate; 804. a storage area; 9. a first baffle plate; 10. a second baffle; 11. connecting a slideway; 12. a second motor; 13. a guide chute; 14. a screw; 15. a first slide rail; 16. a first slider; 17. a second slide rail; 18. a second slider; 19. a reaction cup; 1901. a reaction cup; 1902. b, a reaction cup; 20. a guide block; 21. a guide wheel; 22. mounting a plate; 23. a first conveyor belt; 2301. a first detection end; 2302. a second detection terminal; 24. a third motor; 25. a second sensor; 26. a first sensor; 27. a collection chute; 28. pushing the sheet; 29. a belt; 30. an eighth motor; 31. a first baffle plate; 3101. a first body; 3102. a first limiting part; 3103. a second limiting part; 32. a second baffle plate; 33. a third baffle plate; 34. a fourth baffle plate; 35. a fifth baffle plate; 36. collecting the rail; 37. a buffer inlet; 38. a buffer outlet; 39. a fourth motor; 40. a fifth motor; 41. a sixth motor; 42. a seventh motor; 43. and a screw rod.
Detailed Description
In order to make the technical problems solved, technical solutions adopted and technical effects achieved by the present invention clearer, the technical solutions of the embodiments of the present invention will be described in further detail below with reference to the accompanying drawings, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 5 and 7 to 11, the immunoassay analyzer provided by the present invention comprises a loading module 100 and a buffer module 200, wherein the buffer module 200 comprises a buffer inlet 37, a buffer outlet 38 and a partition plate assembly 8 (shown in fig. 4), the buffer inlet 37 is communicated with the loading module 100, the partition plate assembly 8 is disposed between the buffer inlet 37 and the buffer outlet 38, the partition plate assembly 8 comprises a first partition plate 801 and a second partition plate 802 which are disposed at intervals, a storage area 804 is formed between the first partition plate 801 and the second partition plate 802, the storage area 804 is used for temporarily storing the reaction cup 19 at the extreme end of the buffer module 200, and the first partition plate 801 and the second partition plate 802 are both movable to alternatively block the buffer outlet 38, when the first partition 801 blocks the buffer outlet 38, the reaction cup 19 at the end of the buffer module 200 enters the storage area 804, and the first partition 801 blocks the reaction cups 19 in the storage area 804 from being separated from the buffer module 200; when the second partition 802 blocks the buffer outlet 38, the reaction cups 19 in the storage area 804 can be detached from the buffer module 200. By arranging the buffer module 200, the direction of the reaction cups 19 can be adjusted, and disordered reaction cups 19 are orderly separated from the buffer module 200, so that automatic feeding is realized; by providing the partition assembly 8, the storage area 804 in the partition assembly 8 can control the number of cuvettes 19 leaving the buffer outlet 38 at a time, thereby preventing too many cuvettes 19 from leaving the buffer module 200 at the same time and avoiding congestion at the buffer outlet 38.
Specifically, referring to fig. 1 to 3, the loading module 100 includes a bin 1 and a second conveyor belt 2, and the second conveyor belt 2 communicates the bin 1 and the buffer module 200. By arranging the silo 1, the reaction cups 19 can be placed into the silo 1 disorderly, and then the reaction cups 19 are conveyed by the second conveying belt 2, so that the workload of personnel is reduced.
Specifically, referring to fig. 3, a partition plate 104 is disposed in the silo 1, the partition plate 104 divides the silo 1 into a first area 101 and a second area 102, the first area 101 is larger than the second area 102, the first area 101 and the second area 102 are communicated through an opening 103, an inlet end of the silo 1 is disposed in the first area 101, and an outlet end of the silo 1 is disposed in the second area 102. Through setting up opening 103, can restrict the quantity that gets into reaction cup 19 in second region 102, avoid a large amount of reaction cups 19 to pile up at the exit end, avoid material loading module 100 to appear the card phenomenon.
Specifically, referring to fig. 3, the partition plate 104 is provided with a notch, the notch and the inner wall of the storage bin 1 form an opening 103, when machining is performed, the partition plate 104 can be directly cut, and then the cut partition plate 104 is assembled with the storage bin 1, so that the machining difficulty of the feeding module 100 can be reduced.
Specifically, referring to fig. 3, the opening 103 is located below the first region 101, so that the reaction cups 19 in the first region 101 can be ensured to fall into the second region 102, and dead corners in the first region 101 are avoided.
Specifically, the cup height of the reaction cup 19 is L1, the height of the opening 103 is L2, the width of the opening 103 is L3, L2 is more than or equal to 2L1, and L3 is more than or equal to 3L1, so that the reaction cup 19 in the first area 101 can smoothly enter the second area 102, and the reaction cup 19 is prevented from being blocked at the opening 103.
Specifically, referring to fig. 4, a plurality of conveying positions 201 are disposed on the second conveyor 2, and one conveying position 201 can accommodate one reaction cup 19, so as to initially sequence the reaction cups 19, and avoid congestion caused by too many reaction cups 19 entering the buffer box 5 at the same time.
Specifically, referring to fig. 4 and 5, the second conveyor belt 2 is disposed obliquely, the first feeding end 202 of the second conveyor belt 2 is located below the second feeding end 203, and at this time, the storage bin 1 can be placed in a space above the first feeding end 202, so that the utilization rate of the space of the feeding module 100 is improved.
Specifically, referring to fig. 4, the feeding module 100 further includes a guide block 20, the guide block 20 is disposed between the exit end of the silo 1 and the first feeding end 202 of the second conveyor 2, the guide block 20 is reciprocally movable in the conveying direction of the second conveyor 2, and the guide block 20 may selectively block the exit end of the silo 1. By arranging the guide block 20, the outlet end of the silo 1 can be blocked and communicated by the reciprocating movement of the guide block 20, so that the reaction cups 19 can orderly enter the conveying positions 201 on the second conveying belt 2.
Specifically, referring to fig. 4, the feeding module 100 includes a first motor 4, the first motor 4 is disposed on a frame 3 of the immunoassay analyzer, the first motor 4 drives a second conveyor belt 2 to rotate, in this embodiment, the first motor 4 also drives a guide block 20 to move, a first rotating shaft of the first motor 4 is connected to the guide wheel 21, referring to fig. 6, a screw 14 is fixed on the guide wheel 21, the guide block 20 is connected to a mounting plate 22, the mounting plate 22 is provided with a guide chute 13 and a first sliding block 16, a nut of the screw 14 is slidably disposed in the guide chute 13, the frame 3 is provided with a first sliding rail 15, the first sliding block 16 is slidably disposed on the first sliding rail 15, a length direction of the first sliding rail 16 is consistent with a conveying direction of the second conveyor belt 2, the guide chute 13 is perpendicular to a length direction of the first sliding rail 16, the first motor 4 operates to drive the guide wheel 21 to rotate, when the guide wheel 21 rotates, the nut of screw 14 will form the extrusion to the cell wall of direction spout 13, drive mounting panel 22 motion, under the effect of first slide rail 16, the rotary motion of leading wheel 21 converts first slider 16 into the linear motion along first slide rail 15 length direction, thereby drive mounting panel 22 and remove along the length direction of first slide rail 15, the continuous rotation of leading wheel 21 makes mounting panel 22 can carry out periodic reciprocating motion, make guide block 20 along the direction of delivery reciprocating motion of second conveyer belt 2, realize the orderly material loading of reaction cup 19. Through setting up second conveyer belt 2 and guide block 20 and being driven by same drive power, can reduce the cooperation degree of difficulty of motion between the device, avoid material loading module 100 to appear the card machine phenomenon.
Specifically, referring to fig. 4 and 5, the buffer inlet 37 of the buffer module 200 is located above the buffer outlet 38, a buffer plate 501 is disposed between the buffer inlet 37 of the buffer module 200 and the partition assembly 8, the buffer plate 501 is used for buffering the reaction cups 19 in the buffer module 200, the buffer plate 501 is disposed obliquely, and the buffer plate 501 guides the reaction cups 19 in the buffer module 200 to the buffer outlet 38. By arranging the buffer plate 501, the reaction cup 19 can be adjusted in direction by the gravity of the reaction cup, and ordered feeding is realized.
Specifically, referring to fig. 4 and 5, the buffer module 200 includes a buffer box 5, a buffer plate 501 is disposed on an inner wall of the buffer box 5, the buffer plate 501 is disposed obliquely, and an included angle between an upper surface of the buffer plate 501 and the inner wall of the buffer box 5 is an obtuse angle. By providing the buffer plate 501 having an inclined upper surface, the reaction cuvette 19 can be prevented from being accumulated in the buffer cassette 5.
Specifically, referring to fig. 4 and 5, at least two buffer plates 501 are disposed in the buffer box 5, in this embodiment, two buffer plates 501 are disposed, the buffer box 5 has a first side wall 503 and a second side wall 504 which are opposite, one of the two buffer plates 501 is mounted on the first side wall 503, the other is mounted on the second side wall 504, and the two buffer plates 501 are disposed at intervals. By arranging the buffer plates 501 on the two opposite side walls, the falling motion of the reaction cup 19 can be blocked in two directions, the falling speed of the reaction cup 19 is reduced, and the buffer effect of the falling of the reaction cup 19 is improved. In other embodiments, three, four, or even more buffer plates 501 may be provided as desired.
Specifically, referring to fig. 4 and 5, the bottom of the buffer box 5 is provided with a bottom plate 502, the bottom plate 502 is disposed obliquely, and the cuvette 19 is separated from the buffer box 5 from the lowest portion of the bottom plate 502. The inclined bottom plate 502 can guide the reaction cups 19 in the buffer box 5, thereby preventing the reaction cups 19 from being stacked in the buffer box 5.
Specifically, referring to fig. 4 and 5, the bottom plate 502 is connected to a first side wall 503 of the buffer box 5, the bottom plate 502 is spaced apart from a second side wall 504 of the buffer box 5, and the cuvette 19 is separated from the buffer box 5 by the spacing between the bottom plate 502 and the second side wall 504. At this time, the cuvette 19 forms a Z-shaped movement path in the buffer box 5, so that the speed buffering effect of the buffer box 5 on the cuvette 19 can be improved.
Referring to fig. 4, 5, and 7 to 9, in particular, the buffering module 200 includes a receiving chute 6, a buffering outlet 38 is disposed at one end of the receiving chute 6, the other end of the receiving chute 6 is a receiving end 601, the receiving end 601 is adjacent to the buffering plate 501, the receiving chute 6 is disposed obliquely, the height of the receiving end 601 is higher than that of the buffering outlet 38, the receiving chute 6 guides the reaction cup 19 to the buffering outlet 38, and the first partition plate 801 and the second partition plate 802 of the partition plate assembly 8 alternately block off the buffering outlet 38 of the receiving chute 6. The reaction cups 19 buffered by the buffer plate 501 can be orderly arranged in the receiving slideway 6, so that the reaction cups 19 can orderly enter the detection module 300, and the reaction cups 19 are prevented from being blocked; through setting up the inclined slide 6 of accepting, reaction cup 19 can remove through the action of gravity of self, reduces immunoassay appearance's power consumption, makes immunoassay appearance more energy-conserving.
Specifically, referring to fig. 7 to 9, the receiving chute 6 is groove-shaped, a convex ring is arranged on the circumference of the outer surface of the reaction cup 19, the cup bottom of the reaction cup 19 is located in the receiving chute 6, the convex ring of the reaction cup 19 is overlapped on the notch of the receiving chute 6, the groove-shaped receiving chute 6 is matched with the convex ring of the reaction cup 19, so that the cup opening of the reaction cup 19 faces upward, the cup bottom of the reaction cup 19 is located in the receiving chute 6, the workload of manual sorting is reduced, and the automatic operation of the immunoassay analyzer is realized.
Specifically, referring to fig. 5, 7 and 8, the receiving chute 6 is provided with a first sensor 26, and the first sensor 26 can determine the number of the reaction cups 19 on the receiving chute 6, so as to control the movement of the partition plate assembly 8, so that the reaction cups 19 can sequentially enter the detection module 300.
Specifically, the first sensor 26 is a photoelectric switch, which is a short name for a photoelectric proximity switch, and detects the presence or absence of an object by turning on a circuit through a synchronous circuit by using the shielding or reflection of the detected object on a light beam. The object is not limited to metal, and all objects that reflect light (or block light) can be detected. The photoelectric switch converts the input current into an optical signal on the transmitter to be emitted, and the receiver detects the target object according to the intensity or the existence of the received light.
Specifically, referring to fig. 4, 5, 7 to 9, a transition plate 7 is disposed between the receiving chute 6 and the buffer box 5, a height of the transition plate 7 near one end of the receiving chute 6 is lower than a height of the transition plate 7 far from one end of the receiving chute 6, and the transition plate 7 is used for receiving the reaction cups 19 output from the buffer box 5 and guiding the reaction cups 19 into the receiving chute 6. The transition plate 7 which is obliquely arranged can adjust the direction of the reaction cups 19 by utilizing the self gravity of the reaction cups 19, so that the unordered reaction cups 19 can orderly enter the bearing slide ways 6, automatic feeding is realized, and the workload of manual sorting is reduced.
Specifically, the included angle between the transition plate 7 and the projection of the transition plate on the horizontal plane is 15-90 degrees, so that the reaction cup 19 can be ensured to smoothly slide into the receiving slideway 6.
Specifically, referring to fig. 4, in the length direction of the receiving chute 6, the size of the transition plate 7 is larger than the size of the spacing position between the bottom plate 502 and the second side wall 504 of the buffer box 5, it can be understood that the reaction cups 19 will roll towards different directions after leaving the buffer box 5, and the provision of the transition plate 7 with a larger size can ensure that the transition plate 7 can receive all the reaction cups 19 which roll dispersedly, and ensure that all the reaction cups 19 can enter the receiving chute 6.
In this embodiment, referring to fig. 9 and 11, the partition plate assembly 8 includes a connecting plate 803, the first partition plate 801, the second partition plate 802 and the connecting plate 803 together form a storage area 804, the first partition plate 801 and the second partition plate 802 of the partition plate assembly 8 are respectively arranged on two sides of the connecting plate 803 in the width direction, in this embodiment, the connecting plate 803 is longer than the first partition plate 801 and the second partition plate 802, the first partition plate 801 is aligned with one end of the connecting plate 803, the length of the first partition plate 801 is shorter than the length of the connecting plate 803 to form an inlet of the storage area, so as to ensure that when the first partition plate 801 leaves the receiving chute 6, the reaction cup 19 can enter the storage area 804 from the inlet, the second partition plate 802 is opposite to the inlet of the storage area 804, in this embodiment, the second partition plate 802 is aligned with one end of the connecting plate 803 far from the first partition plate 801, the length of the second partition plate 802 is shorter than the connecting plate 803 to form an outlet of the storage area 804, so as to ensure that the reaction cups 19 can leave the storage area 804 from the outlet when the second partition 802 leaves the receiving slide 803, of course, the outlet of the storage area 804 is opposite to the position of the first partition 801, and the connecting plate 803 can move along the width direction of the receiving slide 6, and referring to fig. 9 and 10, the connecting plate 803 has a first position and a second position, when the connecting plate 803 is in the first position, the first partition 801 blocks the buffer outlet 38, and when the connecting plate 803 is in the second position, the second partition 802 blocks the buffer outlet 38. By arranging the connecting plate 803, the relative distance between the first partition plate 801 and the second partition plate 802 can be ensured, and the difficulty in controlling the movement of the first partition plate 801 and the second partition plate 802 is reduced; in this embodiment, only a single reaction cup 19 can be accommodated in the storage area 804, and the connection plate 803 is provided to ensure that the distance between the first partition 801 and the second partition 802 is constant, thereby ensuring that the size of the space in the storage area 804 is constant and ensuring that the storage area 804 can accommodate only a single reaction cup 19; the connecting plate 803 is provided to move the first partition 801 and the second partition 802 synchronously, thereby reducing the difficulty of controlling the positions of the first partition 801 and the second partition 802.
In other embodiments, the first partition 801 and the second partition 802 may be connected using a connecting rod, one end of which is connected to a side of the first partition 801 near an inlet of the storage area 804 and the other end of which is connected to a side of the second partition 802 near an outlet of the storage area 804.
In one embodiment, the first partition 801 and the second partition 802 are two separate parts, and two motors may be used to control the movement of the first partition 801 and the second partition 802, respectively.
In one embodiment, the first partition 801 and the second partition 802 are both located above the receiving chute 6, and the first partition 801 and the second partition 802 move in a direction perpendicular to the receiving chute 6 to enter or leave the receiving chute 6, in this embodiment, the first partition 801 and the second partition 802 are driven by two motors, taking the first partition 801 as an example: the first partition plate 801 is connected with an output shaft of the motor, the first partition plate 801 leaves the receiving slideway 6 by positive rotation of the output shaft of the motor, and the first partition plate 801 enters the receiving slideway 6 by negative rotation of the output shaft of the motor. The receiving chute 6 may be provided with a sliding groove or a sliding rail to guide the movement of the first partition 801 and the second partition 802.
Specifically, referring to fig. 7 to 11, a second motor 12 and a second slide rail 17 are arranged on the rack 3, a connecting plate 803 of the partition plate assembly 8 is connected to a second slider 18, the second slider 18 is slidably arranged on the second slide rail 17, a second rotating shaft of the second motor 12 is connected to the lead screw 43, the lead screw 43 is in threaded connection with the second slider 18, and when the second motor 12 rotates, the rotating motion of the lead screw 43 is changed into the linear motion of the second slider 18 under the action of the second slide rail 17, so that the partition plate assembly 8 is driven to move along the length direction of the second slide rail 17, thereby realizing the automatic feeding of the reaction cup 19 and reducing the manual work amount.
Specifically, referring to fig. 4, 5 and 9, the first baffle 9 is disposed at the end of the receiving end 601 of the receiving chute 6, so as to prevent the reaction cup 19 from falling from the receiving end 601, and ensure the operation effect of the feeding module 100.
Specifically, referring to fig. 4, 5 and 9, the receiving chute 6 is provided with a second baffle 10, the second baffle 10 is disposed at the receiving end 601, the second baffle 10 is disposed at a side of the receiving chute 6 far away from the transition plate 7, and the second baffle 10 is disposed to prevent the reaction cup 19 from falling from the receiving end 601, so as to ensure the operation effect of the feeding module 100.
In particular, with reference to fig. 4, 5, 7 and 8, the buffer outlet 38 of the buffer module 200 is provided with a connection chute 11. In this embodiment, the connecting chute 11 is vertically disposed, and the receiving chute 6 is inclined, so that the reaction cup 19 located at the buffer outlet 38 has a moving speed in a horizontal direction, and by disposing the vertical connecting chute 11, the moving direction of the reaction cup 19 can be changed, the moving speed of the reaction cup 19 in the horizontal direction can be eliminated, and the reaction cup 19 can stably fall into a subsequent module.
Specifically, referring to fig. 1, 2 and 12, the immunoassay analyzer includes a detection module 300, the detection module includes a first conveyor belt 23, the first conveyor belt 23 has a first detection end 2301 and a second detection end 2302, the first detection end 2301 is located below the outlet of the connecting slide 11, the reaction cup 19 exits from the outlet of the connecting slide 11 and enters the first conveyor belt 23 from the first detection end 2301, a blocking plate assembly 3001 is disposed on the first conveyor belt 23, and the blocking plate assembly 3001 selectively blocks the reaction cup 19 on the first conveyor belt 23. Because the sample adding operation of the reaction cup 19 is involved in the detection module 300, the requirement on the precision of the position of the reaction cup 19 is high, the baffle plate component 3001 is arranged, the reaction cup 19 can be positioned in a mode of obstructing the movement of the reaction cup 19, the positioning precision is provided, and the automatic operation of the immunoassay analyzer is realized.
Specifically, referring to fig. 12, a detection position is arranged between the first detection end 2301 and the second detection end 2302, the barrier plate assembly 3001 includes a first barrier plate 31 and a second barrier plate 32, the first barrier plate 31 and the second barrier plate 32 are arranged at intervals along the conveying direction of the first conveying belt 23, the first barrier plate 31 is located on one side of the second barrier plate 32 close to the first detection end 2301, both the first barrier plate 31 and the second barrier plate 32 have a blocking state and a communicating state, when the first barrier plate 31 is located above the first conveying belt 23, the first barrier plate 31 is in the blocking state, and when the first barrier plate 31 is located on the side of the first conveying belt 23, the second barrier plate 32 is in the communicating state; the blocking state and the communicating state of the second shutter 32 are similar to those of the first shutter 31; when the first blocking piece 31 is in the connection state, the reaction cup 19 can move from the first detection end 2301 to the designated detection position, and when the second blocking piece 32 is in the blocking state, the reaction cup 19 can stay at the designated detection position. The detection position is internally provided with a sample adding needle which can inject sample liquid, buffer solution or other liquid into the reaction cup 19. Through setting up first separation blade 31 and second separation blade 32, can avoid reaction cup 19 to block up in detecting the position, improve the precision of application of sample operation to improve the reliability of realizing the effect.
Referring to fig. 12 and 13, specifically, the first blocking plate 31 includes a first body 3101, a first limiting portion 3102 and a second limiting portion 3103 are protruded from one side of the first body 3101 at an interval, the first limiting portion 3102 is located on one side of the second limiting portion 3103 close to the first detection end 2301, the second limiting portion 3103 is longer than the first limiting portion 3102, and the reaction cup 19 is located between the first limiting portion 3102 and the second limiting portion 3103. When application of sample needle injected liquid into reaction cup 19, reaction cup 19 may appear rocking and shifting, sets up the first separation blade 31 of U type, can make reaction cup 19 can be accurately inject in detecting the position, avoids reaction cup 19 skew to detect the position, improves the precision of application of sample operation.
Specifically, the first stopper portion 3102 is located on the side of the second stopper portion 3103 close to the first detection end 2301, and the length of the second stopper portion 3103 is greater than the length of the first stopper portion 3102. In operation, the first conveyor belt 23 is in a continuous conveying state, and when the first blocking piece 31 moves from the communicating state to the blocking state, the moving reaction cup 19 can be blocked by the second limiting portion 3103 having a longer length, and at this time, the first blocking piece 31 continuously moves to limit the reaction cup 19 between the second limiting portion 3103 and the first limiting portion 3102. By providing the second stopper 3103 having a long length, the difficulty of blocking the moving reaction cup 19 by the first stopper 31 can be reduced.
Certainly, the second baffle 32 is correspondingly provided with a second body, one side of the second body is convexly provided with a third limiting part and a fourth limiting part which are spaced from each other, the reaction cup 19 is located between the third limiting part and the fourth limiting part, at this time, the second baffle 32 is U-shaped, and the reaction cup 19 is located in the U-shaped structure of the second baffle 32. Of course, the first and second blocking pieces 31 and 32 may have a plate-shaped structure for cost saving.
Specifically, referring to fig. 12, in the present embodiment, the flap assembly 3001 further includes a third flap 33, a fourth flap 34 and a fifth flap 35, and the number of the flaps can be flexibly set according to the operation requirement.
Specifically, referring to fig. 12, a third motor 24, a fourth motor 39, a fifth motor 40, a sixth motor 41 and a seventh motor 42 are respectively mounted on the frame 3 of the immunoassay analyzer, and the third motor 24, the fourth motor 39, the fifth motor 40, the sixth motor 41 and the seventh motor 42 respectively drive the first blocking piece 31, the second blocking piece 32, the third blocking piece 33, the fourth blocking piece 34 and the fifth blocking piece 35 to move.
Referring to fig. 12 and 13, in the present embodiment, a third blocking piece 33, a fourth blocking piece 34, a first blocking piece 31, a second blocking piece 32, and a fifth blocking piece 35 are sequentially provided at intervals in the conveying direction of the first conveyor belt 23, the third blocking piece 33 and the fourth blocking piece 33 are plate-shaped, and the first blocking piece 34, the second blocking piece 32, and the fifth blocking piece 35 are U-shaped. a reaction cup 1901 and a reaction cup 1902 enter the first conveyor belt 23 from the first detection end 2301 in sequence, after the reaction cup 1901 passes through the third blocking piece 33, the fifth motor 40 drives the third blocking piece 33 to move, the third blocking piece 33 blocks the reaction cup 1902 b located behind the reaction cup 1901, the reaction cup 1901 continuously advances along the conveying direction of the first conveyor belt 23 to be blocked by the fourth blocking piece 34, at this time, the reaction cup 1901 a is located at a detection position between the third blocking piece 33 and the fourth blocking piece 34, and a sample injection needle arranged at the detection position can add a buffer solution to the reaction cup 1901 a; after the buffer solution is added, the sixth motor 41 drives the fourth blocking piece 34 to move away, the a reaction cup 1901 continues to continuously advance along the conveying direction of the first conveying belt 23 until being blocked by the first blocking piece 31, the a reaction cup 1901 is located between the first limiting portion 3102 and the second limiting portion 3103 of the first blocking piece 31, the sample adding needle arranged at the detection position can inject sample solution (such as an extracted blood sample to be detected) into the a reaction cup 1901, the newly added sample solution and the original buffer solution in the a reaction cup 1901 form a mixed solution, and in this step, the b reaction cup 1902 replaces the a reaction cup 1901 to move between the third blocking piece 33 and the fourth blocking piece 34; after the sample solution in the a reaction cup 1901 is added, the third motor 24 drives the first blocking piece 31 to move away, the a reaction cup 1901 continues to continuously advance along the conveying direction of the first conveying belt 23 until being blocked by the second blocking piece 32, the a reaction cup 1901 is located between the third limiting part and the fourth limiting part of the second blocking piece 32, the sample adding needle arranged at the detection position extracts part of the mixed solution in the a reaction cup 1901, and the mixed solution is used for detection; after the liquid extraction is completed, the fourth motor 39 drives the second blocking piece 32 to move away, the a reaction cup 1901 continues to continuously advance along the conveying direction of the first conveying belt 23 until being blocked by the fifth blocking piece 35, the a reaction cup 1901 is located in the U-shaped structure of the fifth blocking piece 35, the waste liquid extraction needle arranged at the detection position extracts all the residual mixed liquid in the a reaction cup 1901, after the extraction is completed, the seventh motor 42 drives the fifth blocking piece 35 to move away, and the a reaction cup 1901 continues to continuously advance along the conveying direction of the first conveying belt 23 until leaving the first conveying belt 23.
Specifically, referring to fig. 12, the second sensor 25 is disposed at the first detecting end 2301 of the first conveyer belt 23, the second sensor 25 can identify the number of the cuvettes 19 entering the detecting module 300, and record the time interval between two adjacent cuvettes 19 entering the first conveyer belt 23, and in combination with the conveying speed of the first conveyer belt 23, the immunoassay analyzer can automatically determine the distance between two adjacent cuvettes 19, and the immunoassay analyzer controls the positions of the first blocking piece 31, the second blocking piece 32, the third blocking piece 33, the fourth blocking piece 34 and the fifth blocking piece 35 according to the distance between two adjacent cuvettes 19, so as to implement automatic operation.
Specifically, the second sensor 25 is an opto-electronic switch, which can improve the accuracy of monitoring.
Referring to fig. 1, 2 and 14, in particular, the immunoassay analyzer further comprises a collection module 400, the collection module 400 comprises a collection slide 27 and a collection bin, the collection slide 27 connects the second detection end 2302 of the first conveyor belt 23 with the collection bin, and the reaction cups 19 in the detection module 300 are collected and discarded by the collection module 400 after being used.
Referring to fig. 14, the collecting module 400 includes a pushing plate 28, an eighth motor 30, a belt 29 and a collecting rail 36, the pushing plate 28 is slidably disposed on the collecting rail 36, the pushing plate 28 is connected to the belt 29, the eighth motor 30 drives the pushing plate 28 to move along the length direction of the collecting rail 36 by driving the belt 29 to move, the pushing plate 28 can push the cuvettes 19 located at the second detecting end 2302 of the first conveyor belt 23 into the collecting bin through the collecting chute 27, or can push only the cuvettes 19 located at the second detecting end 2302 of the first conveyor belt 23 onto the collecting chute 27, so that the cuvettes 19 located at the end of the collecting chute 27 automatically fall into the collecting bin by stacking among a plurality of cuvettes 19.

Claims (10)

1. An immunoassay analyzer comprises a feeding module and is characterized by further comprising a buffering module, wherein the buffering module comprises a buffering inlet, a buffering outlet and a partition plate assembly, the buffering inlet is used for being communicated with the feeding module, the partition plate assembly is arranged between the buffering inlet and the buffering outlet, the partition plate assembly comprises a first partition plate and a second partition plate which are arranged at intervals, a storage area is formed between the first partition plate and the second partition plate and used for storing materials of the buffering module, which are close to the buffering outlet, the first partition plate and the second partition plate can move to alternately block the buffering outlet, when the first partition plate blocks the buffering outlet, the materials in the buffering module, which are close to the buffering outlet, enter the storage area, and the first partition plate blocks the materials in the storage area from entering the buffering outlet, when the second partition plate blocks the buffer outlet, the materials in the storage area can enter the buffer outlet.
2. The immunoassay analyzer of claim 1, wherein the baffle assembly comprises an attachment plate through which the first baffle and the second baffle are connected.
3. The immunoassay analyzer of claim 2, wherein the first partition and the second partition are disposed on two sides of the connecting plate, respectively, the connecting plate having a first position and a second position, the first partition blocking the buffer outlet when the connecting plate is in the first position, and the second partition being away from the buffer outlet; when the connecting plate is located at the second position, the second partition plate blocks the buffer outlet, and the first partition plate is far away from the buffer outlet.
4. The immunoassay analyzer of claim 1, wherein the buffer module comprises an inclined receiving chute, one end of the receiving chute is communicated with the buffer inlet, the other end of the receiving chute is provided with the buffer outlet, and the receiving chute guides the material from the buffer inlet to the buffer outlet.
5. The immunoassay analyzer of claim 4, wherein the receiving chute is provided with a first sensor for detecting whether the material is present in the receiving chute.
6. The immunoassay analyzer of claim 1, comprising a detection module, wherein the detection module comprises a first conveyor belt, the first conveyor belt has a first detection end and a second detection end, the first conveyor belt is provided with a detection position, the detection position is located between the first detection end and the second detection end, the material exits from the buffer outlet and enters the first conveyor belt from the first detection end, and the first conveyor belt is provided with a baffle assembly, and the baffle assembly selectively obstructs the material on the first conveyor belt from staying at the detection position.
7. The immunoassay analyzer of claim 6, wherein the blocking piece assembly comprises a first blocking piece and a second blocking piece which are arranged at an interval, the first blocking piece is positioned on one side of the second blocking piece close to the first detection end, the first blocking piece and the second blocking piece both have a blocking state and a communicating state, when the first blocking piece is in the communicating state, the material can move from the first detection end to the detection position, and when the second blocking piece is in the blocking state, the material can stay at the detection position.
8. The immunoassay analyzer of claim 7, wherein the first blocking sheet has a first body, a first limiting portion and a second limiting portion are arranged on one side of the first body in a protruding manner, and the material is located between the first limiting portion and the second limiting portion; and/or the presence of a gas in the gas,
the second stopper has a second body, one side protrusion of second body is provided with spacing third spacing portion and spacing fourth portion, the material is located spacing portion of third with between the spacing portion of fourth.
9. The immunoassay analyzer of claim 8, wherein the first position-limiting portion is located on a side of the second position-limiting portion close to the first detection end, and the length of the second position-limiting portion is greater than the length of the first position-limiting portion; and/or the presence of a gas in the gas,
the third limiting part is positioned on one side of the fourth limiting part close to the first detection end, and the length of the fourth limiting part is greater than that of the third limiting part.
10. The immunoassay analyzer of claim 6, wherein the first detection end is provided with a second sensor for detecting whether the material is present within the first conveyor belt.
CN202110805150.XA 2021-07-16 2021-07-16 Immunoassay analyzer Active CN113376368B (en)

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