CN113376095B - Signal integrated optical micro-flow sensor - Google Patents
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- CN113376095B CN113376095B CN202110498159.0A CN202110498159A CN113376095B CN 113376095 B CN113376095 B CN 113376095B CN 202110498159 A CN202110498159 A CN 202110498159A CN 113376095 B CN113376095 B CN 113376095B
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
- G01N2021/458—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods using interferential sensor, e.g. sensor fibre, possibly on optical waveguide
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Abstract
The invention is suitable for the technical field of sensors and provides a signal integrated optical microfluidic sensor; the method comprises the following steps: a micro-nano quartz capillary tube and a plurality of micro-nano optical fibers with the same structure; the micro-nano optical fibers are arranged around the micro-nano quartz capillary; the micro-nano optical fibers and the micro-nano quartz capillary tubes are arranged in a parallel position relationship, and are packaged together; wherein, the micro-nano quartz capillary comprises: the micro-tube comprises a first micro-tube end region, a second micro-tube end region, a first micro-tube conical region, a second micro-tube conical region and a micro-tube uniform region, wherein the first micro-tube conical region and the second micro-tube conical region are respectively positioned at two ends of the micro-tube uniform region, the first micro-tube end region is positioned at the outer end of the first micro-tube conical region, and the second micro-tube end region is positioned at the outer end of the second micro-tube conical region.
Description
Technical Field
The invention relates to the technical field of sensors, in particular to a signal integrated optical micro-flow sensor.
Background
The optical microfluidic sensor combines the characteristics of a microfluidic system such as low sample consumption, cheap sample treatment, high signal-to-noise ratio and high flux, and also combines the characteristics of an optical sensor such as high sensitivity, good compatibility and low power consumption, and has good development potential in the aspects of medical detection, biochemical measurement and the like. Under the great development trend of integration and miniaturization, the optical microfluidic sensor shows irreplaceable advantages due to small structure size and excellent sensing performance. Sensor-based sensing techniques require multiple sensing to obtain more accurate measurements, and therefore integration of sensors is being promoted. Besides the function integration to realize the simultaneous measurement of multiple indexes and multiple parameters, the same index of the same parameter is also very important for the simultaneous measurement of multiple times of the same sample.
At present, multiple simultaneous detection modes for realizing single index of single parameter based on integration of optical microfluidic sensors are various. In the simplest way, the microfluidic chip is designed to contain a plurality of measurement cells, in each of which an optical detection structure is introduced separately. The chip structure realizes the shunting and processing of the sample, and the multi-path simultaneous measurement reduces the time consumption, but the integration basically belongs to simple physical integration, and has no revolutionary improvement on cost, sample consumption and system volume. Due to the poor compatibility between the optical structure and the chip on materials, the detection precision achieved by the method is limited, and the method has great limitation on application. The optical waveguide with the microporous structure can directly form an optical microfluidic sensor without other structures, such as photonic crystals, liquid core optical waveguides and the like, and the optical microfluidic sensor has a natural porous structure, sample consumption is as low as femtogram level, and light and substances have strong interaction, so that the sensitivity is very high, and the measuring capability is greatly improved. It would be advantageous if the optical waveguides themselves could be integrated directly. The resonant ring optical microfluidic sensor formed by the vertical interaction of the micro-nano optical fibers and the micro-tube can be realized, namely a plurality of parallel micro-nano optical fibers and one micro-tube form a plurality of resonant ring optical microfluidic sensors to realize multi-path simultaneous detection. The integrated resonant ring optical microfluidic sensor has a simple structure, and the sample consumption is the same as that of a single sensor. However, the optical signal of the structure is easily interfered by the outside, and the detection process has extremely high requirements on the surrounding environment. If the sensor structure is packaged, the quality factor of the sensor structure is greatly affected, thereby reducing the detection capability.
Different forms of optical microfluidic sensors have different integration capabilities, and different integration forms and advantages and disadvantages, but the integration of the sensor at the optical device level has strong advantages.
Disclosure of Invention
The present invention is directed to a signal integrated optical microfluidic sensor, which solves the above problems.
In order to achieve the purpose, the invention provides the following technical scheme:
a signal integrated optical microfluidic sensor, comprising: a micro-nano quartz capillary tube and a plurality of micro-nano optical fibers with the same structure; the micro-nano optical fibers are arranged around the micro-nano quartz capillary; the micro-nano optical fibers and the micro-nano quartz capillary tubes are arranged in a parallel position relationship, and are packaged together;
wherein, the micro-nano quartz capillary comprises: the micro-tube comprises a first micro-tube end region, a second micro-tube end region, a first micro-tube conical region, a second micro-tube conical region and a micro-tube uniform region, wherein the first micro-tube conical region and the second micro-tube conical region are respectively positioned at two ends of the micro-tube uniform region, the first micro-tube end region is positioned at the outer end of the first micro-tube conical region, and the second micro-tube end region is positioned at the outer end of the second micro-tube conical region;
the micro-nano optical fibers are provided with a first micro-optical fiber end region, a second micro-optical fiber end region, a first micro-optical fiber conical region, a second micro-optical fiber conical region and a micro-optical fiber uniform region; the first micro optical fiber cone area and the second micro optical fiber cone area are respectively positioned at two ends of the micro optical fiber uniform area, the first micro optical fiber end area is positioned at the outer end of the first micro optical fiber cone area, and the second micro optical fiber end area is positioned at the outer end of the second micro optical fiber cone area; and a plurality of micro-nano optical fibers with the same composition structure form a plurality of independent optical signal channels.
As a further scheme of the invention: the first micro optical fiber end region and the second micro optical fiber end region are used for inputting and outputting optical signals, the first micro optical fiber conical region of the micro-nano optical fibers and the first micro tube conical region or the second micro optical fiber conical region and the second micro tube conical region are parallelly and tightly combined side by side, and excitation and coupling of multiple groups of high-order modes are achieved respectively.
As a still further scheme of the invention: and the excited multiple groups of high-order modes and the multiple fiber fundamental modes are relatively independently transmitted in a composite waveguide structure respectively formed by a micro-tube uniform area of the micro-nano quartz capillary and micro-fiber uniform areas of the micro-nano fibers.
As a still further scheme of the invention: multiple groups of high-order mode evanescent fields transmitted by the micro-tube uniform area and the micro-fiber uniform area respectively penetrate into the micro-nano quartz capillary tube, and a local sensitive area is formed on the inner side of the micro-tube close to the micro-nano optical fibers, so that the interaction between light and a substance is realized, and the purpose of sensing measurement is achieved.
As a still further scheme of the invention: the first micro-tube end region and the second micro-tube end region of the micro-nano quartz capillary tube are used for inputting and outputting a sample, and independent ports are formed to form a complete independent micro-flow channel system.
As a still further scheme of the invention: the optical fiber monitoring system comprises a plurality of micro-nano optical fibers, a first micro-optical fiber end region and a second micro-optical fiber end region, wherein one end of each of the micro-nano optical fibers is connected with a light source and used for inputting optical signals, the other end of each of the micro-nano optical fibers is connected with a spectrometer or a demodulation device and used for monitoring output signals, the structures of the two ends of each of the micro-nano optical fibers are the same, and the plurality of optical fibers and a plurality of complete and independent optical signal channels are arranged.
As a still further scheme of the invention: and a plurality of micro-nano optical fibers and micro-nano quartz capillary tubes are packaged in the ultraviolet glue.
As a still further scheme of the invention: the ultraviolet glue is low-refraction ultraviolet glue.
As a still further scheme of the invention: the number of the micro-nano optical fibers is six.
As a still further scheme of the invention: the micro-nano optical fibers comprise a first micro-nano optical fiber, a second micro-nano optical fiber, a third micro-nano optical fiber, a fourth micro-nano optical fiber, a fifth micro-nano optical fiber and a sixth micro-nano optical fiber.
Compared with the prior art, the invention has the beneficial effects that: the signal integrated optical microfluidic sensor disclosed by the invention is an interference type integrated optical microfluidic sensor based on micro-nano quartz capillary-micro-nano optical fiber wavelength coding, can realize simultaneous detection of multiple paths to be measured, and has the characteristics of high sensitivity and high stability, and is simple to manufacture, convenient to operate, low in cost, good in portability and easy to put into practical use.
Drawings
Fig. 1 is a schematic structural diagram of a signal integrated optical microfluidic sensor.
Fig. 2 is a schematic cross-sectional view of a signal integrated optical microfluidic sensor.
In the figure: 1-a micro-nano quartz capillary tube, 2-a first micro-nano optical fiber, 3-a second micro-nano optical fiber, 4-a third micro-nano optical fiber, 5-a fourth micro-nano optical fiber, 6-a fifth micro-nano optical fiber, 7-a sixth micro-nano optical fiber, 8-a first micro-tube end region, 9-a second micro-tube end region, 10-a first micro-tube conical region, 11-a second micro-tube conical region, 12-a micro-tube uniform region, 13-a first micro-optical fiber end region, 14-a second micro-optical fiber end region, 15-a first micro-optical fiber conical region, 16-a second micro-optical fiber conical region and 17-a micro-optical fiber uniform region.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "first", "second", and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, in the description of the present invention, "a plurality" means two or more unless otherwise specified. A feature defined as "first," "second," etc. may explicitly or implicitly include one or more of the feature.
Examples
Referring to fig. 1-2, in an embodiment of the present invention, a structure diagram of a signal integrated optical microfluidic sensor provided in an embodiment of the present invention includes: a micro-nano quartz capillary tube 1 and a plurality of micro-nano optical fibers with the same structure; the micro-nano optical fibers are arranged around the micro-nano quartz capillary 1; the micro-nano optical fibers and the micro-nano quartz capillary tubes 1 are arranged in a parallel position relationship, and the micro-nano optical fibers and the micro-nano quartz capillary tubes are packaged together.
Wherein, the micro-nano quartz capillary 1 comprises: a first microtube end region 8, a second microtube end region 9, a first microtube conical region 10, a second microtube conical region 11 and a microtube even region 12, wherein the first microtube conical region 10 and the second microtube conical region 11 are respectively positioned at two ends of the microtube even region 12, the first microtube end region 8 is positioned at the outer end of the first microtube conical region 10, and the second microtube end region 9 is positioned at the outer end of the second microtube conical region 11; the above-mentioned regions constitute a microfluidic channel. The first micro-tube end region 8 and the second micro-tube end region 9 are respectively connected with a syringe pump and a waste liquid pool for inputting and outputting samples, and are independent of ports to form a complete independent micro-flow channel system.
The micro-nano optical fibers are provided with a first micro-optical fiber end region 13, a second micro-optical fiber end region 14, a first micro-optical fiber conical region 15, a second micro-optical fiber conical region 16 and a micro-optical fiber uniform region 17; the first micro optical fiber conical area 15 and the second micro optical fiber conical area 16 are respectively positioned at two ends of the micro optical fiber uniform area 17, the first micro optical fiber end area 13 is positioned at the outer end of the first micro optical fiber conical area 15, and the second micro optical fiber end area 14 is positioned at the outer end of the second micro optical fiber conical area 16; the micro-nano optical fibers with the same composition structure form a plurality of independent optical signal channels. The first micro optical fiber end region 13 and the second micro optical fiber end region 14 have one end connected to the light source for inputting light signals and the other end connected to the spectrometer or the demodulator for monitoring output signals, and the two ends are indistinguishable, and multiple optical fibers form multiple complete independent light signal systems.
Thus, a plurality of optical signal paths and a signal integrated optical micro-flow sensor of a micro-flow channel are formed.
The micro-nano optical fibers with the same composition structure and the micro-nano quartz capillary respectively form a plurality of independent optical micro-flow sensors, and optical signal transmission and sensor measurement are not affected.
The first micro optical fiber end region 13 and the second micro optical fiber end region 14 are used for inputting and outputting optical signals, and the first micro optical fiber conical region 15 of the micro-nano optical fibers and the first micro tube conical region 10 or the second micro optical fiber conical region 16 of the micro-nano optical fibers and the second micro tube conical region 11 are closely combined in parallel side by side to respectively realize excitation and coupling of multiple groups of high-order modes.
The excited multiple groups of high-order modes and the multiple fiber fundamental modes are relatively independently transmitted in a composite waveguide structure respectively formed by a micro-tube uniform area 12 of the micro-nano quartz capillary 1 and micro-fiber uniform areas 17 of the micro-nano fibers.
Multiple groups of high-order mode evanescent fields transmitted by the micro-tube uniform area 12 and the micro-fiber uniform area 17 penetrate into the micro-nano quartz capillary tube 1 respectively, and a local sensitive area is formed on the inner side of the micro-tube close to the micro-nano optical fibers, so that the interaction between light and substances is realized, and the purpose of sensing measurement is achieved.
The excited high-order mode and the fundamental mode are transmitted in a composite waveguide structure consisting of a micro-tube uniform region 12 and a micro-fiber uniform region 17. The evanescent field of the composite waveguide high-order mode can penetrate into the micro-nano quartz capillary 1 respectively, a local sensitive area is formed on the inner side of the micro-tube close to the micro-nano optical fibers, sensor measurement of multiple different areas in the micro-tube is achieved, multiple independent optical micro-flow sensors are formed, optical signal transmission and sensor measurement are not affected mutually, and simultaneous detection of multiple paths is achieved.
The first micro-tube end region 8 and the second micro-tube end region 9 of the micro-nano quartz capillary 1 are used for inputting and outputting a sample, and independent ports are formed to form a complete independent micro-flow channel system.
One end of a first micro optical fiber end region 13 and a second micro optical fiber end region 14 of the micro-nano optical fibers is connected with a light source and used for inputting optical signals, the other end of the first micro optical fiber end region is connected with a spectrometer or a demodulation device and used for monitoring output signals, and the two ends of the first micro optical fiber end region and the second micro optical fiber end region are not different.
And a plurality of micro-nano optical fibers and micro-nano quartz capillary tubes are packaged in the ultraviolet glue. The ultraviolet glue is low-refraction ultraviolet glue. This arrangement is used for improving the stability and the portability of structure, does not influence the optical sensing principle of sensor.
The number of the micro-nano optical fibers is six. The micro-nano optical fibers comprise a first micro-nano optical fiber 2, a second micro-nano optical fiber 3, a third micro-nano optical fiber 4, a fourth micro-nano optical fiber 5, a fifth micro-nano optical fiber 6 and a sixth micro-nano optical fiber 7.
The micro-nano optical fiber arrays are arranged on the outer side of the micro-nano quartz capillary tube 1.
In summary, the present embodiment discloses a signal integrated optical microfluidic sensor, which is used for multi-channel simultaneous measurement of parameters such as biology, medicine, chemistry, and physics, and realizes integration of a high-sensitivity and high-stability optofluidic sensor. The integrated optical micro-flow sensor is composed of a micro-nano quartz capillary tube and a plurality of micro-nano optical fibers, and is parallel and compact in structure. And forming the wavelength-coded interference type optical microfluidic sensor based on the interaction of the evanescent field and the substances in the microtubes. The micro-nano optical fibers and the micro-tubes respectively form a plurality of optical micro-flow sensors, so that simultaneous sensing measurement of a plurality of different local areas of the micro-flow pipeline is realized, optical signal transmission and sensor measurement are not affected with each other, measurement errors are greatly reduced, the accuracy of sensor measurement is improved, and signal integration is realized. The sensor can realize multi-path simultaneous sensing measurement of various biological, medical, chemical, physical and other parameters, and has the advantages of high sensitivity, good stability, simple manufacture, convenient operation, low cost, good portability and easy practicability.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. A signal integrated optical microfluidic sensor, comprising: a micro-nano quartz capillary tube and a plurality of micro-nano optical fibers with the same structure; the micro-nano optical fibers are arranged around the micro-nano quartz capillary; the micro-nano optical fibers and the micro-nano quartz capillary tubes are arranged in a parallel position relationship, and the micro-nano optical fibers and the micro-nano quartz capillary tubes are packaged together;
wherein, the micro-nano quartz capillary comprises: the micro-tube comprises a first micro-tube end region, a second micro-tube end region, a first micro-tube conical region, a second micro-tube conical region and a micro-tube uniform region, wherein the first micro-tube conical region and the second micro-tube conical region are respectively positioned at two ends of the micro-tube uniform region, the first micro-tube end region is positioned at the outer end of the first micro-tube conical region, and the second micro-tube end region is positioned at the outer end of the second micro-tube conical region;
the micro-nano optical fibers are provided with a first micro-optical fiber end region, a second micro-optical fiber end region, a first micro-optical fiber conical region, a second micro-optical fiber conical region and a micro-optical fiber uniform region; the first micro optical fiber cone area and the second micro optical fiber cone area are respectively positioned at two ends of the micro optical fiber uniform area, the first micro optical fiber end area is positioned at the outer end of the first micro optical fiber cone area, and the second micro optical fiber end area is positioned at the outer end of the second micro optical fiber cone area; a plurality of micro-nano optical fibers with the same composition structure form a plurality of independent optical signal channels;
the first micro optical fiber end region and the second micro optical fiber end region are used for inputting and outputting optical signals, and the first micro optical fiber conical region and the first micro tube conical region or the second micro optical fiber conical region and the second micro tube conical region of the micro-nano optical fibers are closely combined in parallel side by side to respectively realize excitation and coupling of multiple groups of high-order modes;
the excited multiple groups of high-order modes and multiple fiber fundamental modes are relatively independently transmitted in a composite waveguide structure respectively formed by a micro-tube uniform area of the micro-nano quartz capillary and micro-fiber uniform areas of the micro-nano fibers;
multiple groups of high-order mode evanescent fields transmitted by the micro-tube uniform area and the micro-fiber uniform area respectively penetrate into the micro-nano quartz capillary tube, and a local sensitive area is formed on the inner side of the micro-tube close to the micro-nano optical fibers, so that the interaction between light and a substance is realized, and the purpose of sensing measurement is achieved.
2. The signal integrated optical microfluidic sensor according to claim 1, wherein the first micro-tube end region and the second micro-tube end region of the micro-nano quartz capillary tube are used for inputting and outputting a sample, and independent ports are formed to constitute a complete independent microfluidic channel system.
3. The integrated optical microfluidic sensor of claim 2, wherein one end of the first micro fiber end region and the second micro fiber end region of the micro-nano fibers is connected to a light source for inputting optical signals, and the other end of the first micro fiber end region and the second micro fiber end region is connected to a spectrometer or a demodulation device for monitoring output signals.
4. The signal integrated optical microfluidic sensor according to any one of claims 1 to 3, wherein the micro-nano optical fibers and the micro-nano quartz capillary tubes are encapsulated in ultraviolet glue.
5. The signal-integrated optical microfluidic sensor according to claim 4, wherein said UV-glue is a low-refractive UV-glue.
6. The signal integrated optical microfluidic sensor according to any one of claims 1 to 3, wherein the number of the micro-nano optical fibers is six.
7. The signal integrated optical microfluidic sensor according to claim 6, wherein the micro-nano optical fibers comprise a first micro-nano optical fiber, a second micro-nano optical fiber, a third micro-nano optical fiber, a fourth micro-nano optical fiber, a fifth micro-nano optical fiber and a sixth micro-nano optical fiber.
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