CN113371282A - Storage device and storage method for degradable zinc alloy bracket - Google Patents
Storage device and storage method for degradable zinc alloy bracket Download PDFInfo
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- CN113371282A CN113371282A CN202110733649.4A CN202110733649A CN113371282A CN 113371282 A CN113371282 A CN 113371282A CN 202110733649 A CN202110733649 A CN 202110733649A CN 113371282 A CN113371282 A CN 113371282A
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- zinc alloy
- degradable zinc
- way valve
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- degradable
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- 229910001297 Zn alloy Inorganic materials 0.000 title claims abstract description 66
- 238000003860 storage Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000007789 sealing Methods 0.000 claims abstract description 36
- 238000011068 loading method Methods 0.000 claims abstract description 18
- 230000001954 sterilising effect Effects 0.000 claims abstract description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 12
- 238000003825 pressing Methods 0.000 claims abstract description 9
- 238000011049 filling Methods 0.000 claims abstract description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 18
- 239000011261 inert gas Substances 0.000 claims description 14
- 239000007789 gas Substances 0.000 claims description 13
- 239000002274 desiccant Substances 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 238000004806 packaging method and process Methods 0.000 claims description 10
- 238000009423 ventilation Methods 0.000 claims description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 8
- 238000007605 air drying Methods 0.000 claims description 5
- 239000001307 helium Substances 0.000 claims description 5
- 229910052734 helium Inorganic materials 0.000 claims description 5
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 239000004775 Tyvek Substances 0.000 claims description 3
- 229920000690 Tyvek Polymers 0.000 claims description 3
- 238000007664 blowing Methods 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229910000861 Mg alloy Inorganic materials 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 229920006237 degradable polymer Polymers 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B63/00—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/04—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/12—Sterilising contents prior to, or during, packaging
- B65B55/16—Sterilising contents prior to, or during, packaging by irradiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D33/00—Details of, or accessories for, sacks or bags
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a storage device for a degradable zinc alloy bracket, which comprises a coil pipe, a three-way valve, a sealing box, a conveying device and a ventilating needle head, wherein the coil pipe is used for loading the degradable zinc alloy bracket; the three-way valve is arranged at the end opening of the inner ring of the coil pipe, the left side of the three-way valve is communicated with the initial end of the coil pipe, and the right side of the three-way valve is provided with an opening for inserting the degradable zinc alloy bracket; the sealing box is arranged at the end port of the outer ring of the coil pipe, and the left side of the sealing box is communicated with the tail end of the coil pipe; the conveying device is used for pressing and holding the degradable zinc alloy bracket and loading the degradable zinc alloy bracket into the coil pipe through the three-way valve; the vent needle is arranged at an opening at the upper end of the three-way valve and is used for filling gas into the coil pipe. The invention can effectively control the stability of the zinc alloy bracket in the storage and sterilization processes, can prolong the shelf life of the bracket and is convenient for industrialization.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a storage device and a storage method for a degradable zinc alloy stent.
Background
The coronary artery stent is a medical apparatus for treating cardiovascular stenosis, and the principle of the interventional operation is to re-expand the blocked coronary artery blood vessel by implanting the stent, so that the blood flow is restored to be smooth again. The instrument has been used more and more widely in the cardiovascular disease field at present. The development of interventional stent procedures has progressed from the first generation of balloon-only stents (PTCA), to the second generation of Bare Metal Stents (BMS), and to the third generation of drug-coated stents (DES), to biodegradable stents (BRS).
The biodegradable stent is made of degradable polymer materials (such as polylactic acid) or metal materials (such as magnesium alloy and zinc alloy), can play a role in supporting blood vessels in a short time after being implanted into a diseased site, rebuilds and restores a blood transport channel, and after the treatment is completed and the function of the blood vessels of the diseased site is restored, the biodegradable stent is gradually degraded into organic matters, metal ions, metal compounds and other substances which can be absorbed and metabolized by a human body in the environment of the human body, and finally the stent can disappear in the diseased site without causing the problems of secondary blockage stenosis and the like in the site.
However, the existing biodegradable stent is sensitive to temperature, oxygen, moisture and other environments, and after sterilization processes such as irradiation and the like, the stent material can quickly undergo chemical or physical changes such as aging, creep, degradation, deformation and the like, so that basic technical requirements of the stent, such as extrusion resistance, radial retraction rate and the like, are influenced. The storage aging of the biodegradable scaffold can also be very short if the storage conditions are not controlled, and the application can be further limited.
CN109878907A discloses a magnesium alloy stent storage box and method, which protect the stent by a sealed box and a mixed gas composed of hydrogen and helium inside the sealed box, but there is no suitable and effective method for the packaging and storage method of the degradable zinc alloy stent, which cannot guarantee the longer physical and chemical stability of the degradable zinc alloy stent, and cannot prolong the storage period of the stent, and is not suitable for industrialization.
Disclosure of Invention
The invention aims to solve the technical problems to a certain extent, and provides a storage device for a degradable zinc alloy bracket, which can effectively control the stability of the zinc alloy bracket in the storage and sterilization processes, can prolong the shelf life of the bracket and is convenient for industrialization.
The technical scheme adopted by the invention for solving the technical problems is as follows: the storage device comprises a coil pipe, a three-way valve, a sealing box, a conveying device and a ventilation needle head, wherein the coil pipe is used for loading the degradable zinc alloy stent; the three-way valve is arranged at the end opening of the inner ring of the coil pipe, the left side of the three-way valve is communicated with the initial end of the coil pipe, and the right side of the three-way valve is provided with an opening for inserting the degradable zinc alloy bracket; the sealing box is arranged at the end port of the outer ring of the coil pipe, and the left side of the sealing box is communicated with the tail end of the coil pipe; the conveying device is used for pressing and holding the degradable zinc alloy bracket and loading the degradable zinc alloy bracket into the coil pipe through the three-way valve; the vent needle is arranged at an opening at the upper end of the three-way valve and is used for filling gas into the coil pipe.
In some preferred embodiments, the end face of the three-way valve perpendicular to the direction of the assembling ventilation needle head extends outwards to form a T-shaped cavity structure.
In certain preferred embodiments, a desiccant is provided within the T-cavity body structure of the three-way valve.
In certain preferred embodiments, a sealing ring is contained within the sealed cartridge.
A storage method of a degradable zinc alloy stent comprises the storage device of the degradable zinc alloy stent, and comprises the following steps:
s1, placing the processed and molded degradable zinc alloy bracket in an air-blast drying box for drying and draining to remove residual cleaning solution;
s2, placing the degradable zinc alloy support dried in the step S1 in an environment with the temperature of 15-25 ℃ and the humidity of 20-30% to be matched with a conveying device for pressing and holding treatment, quickly loading the whole body into a coil pipe from an opening at one side of a three-way valve, and enabling a guide wire at the tail end of the conveying device to penetrate through the sealing box in an opening state to achieve the effect of guide wire clamping;
s3, when the degradable zinc alloy support is loaded, inserting the ventilating needle head in the opening state of the three-way valve, enabling the ventilating needle head to keep a gas-filled state towards the interior of the coil pipe all the time, and enabling the gas in the coil pipe to overflow from the sealing box in the opening state;
s4, closing the three-way valve and the sealing box after loading is finished, pulling out the ventilation needle head, and loading the loaded degradable zinc alloy support and the conveying device into a Tyvek inner packaging bag;
s5, the whole processed in the step S4 is placed into an airtight outer packaging bag packaged with a drying agent, and low-temperature irradiation sterilization is carried out to obtain a finished product.
In certain preferred embodiments, the blowing dry box in the step S1 is baked with nitrogen or inert gas.
In certain preferred embodiments, the drying temperature of the forced air drying oven does not exceed 40 ℃.
In certain preferred embodiments, the dwell time for the crimping in the step S2 is 20-90 seconds.
In certain preferred embodiments, the gas filled in the step S3 is nitrogen or an inert gas.
In certain preferred embodiments, the inert gas is helium or argon.
Compared with the prior art, the technical scheme provided by the embodiment of the application has the following advantages:
the system comprises a coil pipe, a three-way valve, a sealing box, a conveying device, a degradable zinc alloy support, a three-way valve, a sealing box, a sealing ring, a sealing box and a sealing ring, wherein the three-way valve is arranged at an inner ring port of the coil pipe, the sealing box is arranged at an outer ring port of the three-way valve, the conveying device is pressed and held with the degradable zinc alloy support, the degradable zinc alloy support penetrates through the three-way valve to be loaded into the coil pipe, nitrogen or inert gas is filled into the coil pipe during loading, and finally the coil pipe is packaged into a non-breathable outer packaging bag of the sealing agent for low-temperature irradiation sterilization, so that the stability of the zinc alloy support in the storage and sterilization processes can be effectively controlled, the shelf life of the support can be prolonged, and industrialization is facilitated;
furthermore, the residual cleaning solution of the degradable zinc alloy bracket after the preparation and cleaning process is removed by means of nitrogen or inert gas drying in the air-blast drying oven, and meanwhile, the bottom of the air-blast drying oven is loaded with a drying agent, and the drying temperature is not more than 40 degrees, so that the thickness of an oxide layer formed on the surface of the zinc alloy can be controlled and protected.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive exercise.
In the drawings:
FIG. 1 is a schematic structural diagram of a degradable zinc alloy stent storage device according to the present invention;
FIG. 2 is a schematic structural diagram of a degradable zinc alloy stent storage device according to the present invention;
FIG. 3 is an enlarged view of a portion A of FIG. 1 during storage operation;
FIG. 4 is an enlarged view of a portion B of FIG. 1 during storage operation;
FIG. 5 is an enlarged view of a portion of FIG. 1A after storage;
FIG. 6 is an enlarged view of a portion of FIG. 1 at B after storage;
FIG. 7 is a flow chart of a storage method according to the present invention.
Reference numerals: 1-a coil pipe; 2-three-way valve; 3-sealing the box; 4-a conveying device; 5-T-shaped cavity structure; 6-sealing ring.
Detailed Description
For a more clear understanding of the technical features, objects and effects of the present invention, embodiments of the present invention will now be described in detail with reference to the accompanying drawings. In the following description, it is to be understood that the orientations and positional relationships indicated by "front", "rear", "upper", "lower", "left", "right", "longitudinal", "lateral", "vertical", "horizontal", "top", "bottom", "inner", "outer", "leading", "trailing", and the like are configured and operated in specific orientations based on the orientations and positional relationships shown in the drawings, and are only for convenience of describing the present invention, and do not indicate that the device or element referred to must have a specific orientation, and thus, are not to be construed as limiting the present invention.
It is also noted that, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," "disposed," and the like are intended to be inclusive and mean, for example, that they may be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. When an element is referred to as being "on" or "under" another element, it can be "directly" or "indirectly" on the other element or intervening elements may also be present. The terms "first", "second", "third", etc. are only for convenience in describing the present technical solution, and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated, whereby the features defined as "first", "second", "third", etc. may explicitly or implicitly include one or more of such features. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the following description, for purposes of explanation and not limitation, specific details are set forth, such as particular system structures, techniques, etc. in order to provide a thorough understanding of the embodiments of the invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present invention with unnecessary detail.
As shown in fig. 1-6, the invention provides a storage device for a degradable zinc alloy stent, comprising a coil pipe 1, a three-way valve 2, a sealing box 3, a conveying device 4 and a ventilation needle, wherein the coil pipe 1 is used for loading the degradable zinc alloy stent; the three-way valve 2 is arranged at an inner ring port of the coil pipe 1, the left side of the three-way valve is communicated with the initial end of the coil pipe 1, an opening for inserting the degradable zinc alloy bracket is formed in the right side of the three-way valve, the end surface of the three-way valve 2 perpendicular to the direction of the assembling ventilation needle head extends outwards to form a T-shaped cavity body structure 5, and a drying agent is arranged in the T-shaped cavity body structure 5 of the three-way valve 2; the sealing box 3 is arranged at an outer ring port of the coil 1, the left side of the sealing box is communicated with the tail end of the coil 1, and a sealing ring 6 is arranged in the sealing box 3; the conveying device 4 is used for pressing and holding the degradable zinc alloy bracket and loading the degradable zinc alloy bracket into the coil pipe 1 through the three-way valve 2; the vent needle is arranged at an opening at the upper end of the three-way valve 2 and is used for filling gas into the coil pipe 1.
As shown in fig. 7, a method for storing a degradable zinc alloy stent, which comprises the following steps:
s1, placing the processed and molded degradable zinc alloy bracket in an air-blast drying box for drying and draining to remove residual cleaning solution;
specifically, in the step S1, nitrogen or an inert gas is used in the forced air drying oven to dry and blow off the residual cleaning solution, wherein the inert gas is helium or argon, the drying temperature of the forced air drying oven is 37 ℃, a drying agent is further loaded at the bottom of the forced air drying oven, and the drying agent is a physical adsorbent including but not limited to one or more of silica gel, an alumina molecular sieve, and activated carbon:
s2, placing the degradable zinc alloy stent dried in the step S1 in an environment with the temperature of 20 ℃ and the humidity of 25% to be matched with a conveying device 4 for carrying out pressing and holding treatment, wherein the pressure holding time of pressing and holding in the step S2 is 60 seconds, the whole body is rapidly loaded into the coil pipe 1 from an opening on one side of the three-way valve 2, and a guide wire at the tail end of the conveying device 4 can penetrate through the sealing box 3 in an opening state to achieve the effect of guide wire clamping;
s3, when the degradable zinc alloy bracket is loaded, inserting a ventilation needle in the opening state of the three-way valve 2, and enabling the ventilation needle to keep a gas-filled state towards the interior of the coil 1 all the time, wherein the gas filled in the step S3 is nitrogen or inert gas, the inert gas is helium or argon, and meanwhile, the gas in the coil 1 overflows from the sealing box 3 in the opening state;
s4, after loading is finished, closing the three-way valve 2 and the sealing box 3, pulling out the ventilation needle head, and loading the loaded degradable zinc alloy support and the conveying device 4 into a Tyvek inner packaging bag;
s5, the whole body processed in the step S4 is placed into an airtight outer packaging bag packaged with a drying agent, and low-temperature irradiation sterilization is carried out to obtain a finished product, in the step S5, the airtight packaging bag is made of materials which are difficult to permeate oxygen and moisture, and is not limited to aluminum foil bags, polyester bags and polyethylene bags, and the specific materials have the oxygen permeability coefficient of less than 0.02cm under the conditions that the temperature is minus 20-40 ℃, the humidity is 5-80%, and the atmospheric pressure is3/(cm224 h.0.1 MPa), water vapor transmission of less than 0.02cm3/(cm224h 0.1MPa) and simultaneously performing radiation sterilization under a low-temperature environment (above the freezing point and below 4 ℃), wherein the radiation sterilization comprises alpha rays, beta rays, gamma rays, electron beams, neutron beams and X rays,
in the embodiment, the coil 1 is provided with the three-way valve 2 arranged at the inner ring port, the T-shaped cavity body structure 5 of the three-way valve 2 is internally provided with the drying agent, the outer ring port of the three-way valve 2 is provided with the sealing box 3 with the sealing ring 6, the conveying device 4 is pressed and held with the degradable zinc alloy bracket, the degradable zinc alloy bracket passes through the three-way valve 2 to be loaded into the coil 1, nitrogen or inert gas is filled into the coil 1 during loading, and finally the coil is packaged into the airtight outer packaging bag of the drying agent for low-temperature irradiation sterilization, so that the stability of the zinc alloy bracket in the storage and sterilization processes can be effectively controlled, the shelf life of the bracket can be prolonged, and the industrialization is facilitated; furthermore, the residual cleaning solution of the degradable zinc alloy bracket after the preparation and cleaning process is removed by means of nitrogen or inert gas drying in the air-blast drying oven, and meanwhile, the bottom of the air-blast drying oven is loaded with a drying agent, and the drying temperature is not more than 40 degrees, so that the thickness of an oxide layer formed on the surface of the zinc alloy can be controlled and protected.
It is to be understood that the foregoing examples, while indicating the preferred embodiments of the invention, are given by way of illustration and description, and are not to be construed as limiting the scope of the invention; it should be noted that, for those skilled in the art, the above technical features can be freely combined, and several changes and modifications can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention; therefore, all equivalent changes and modifications made within the scope of the claims of the present invention should be covered by the claims of the present invention.
Claims (10)
1. A degradable zinc alloy stent storage device, comprising:
the coil is used for loading the degradable zinc alloy bracket;
the three-way valve is arranged at the end opening of the inner ring of the coil pipe, the left side of the three-way valve is communicated with the initial end of the coil pipe, and the right side of the three-way valve is provided with an opening for inserting the degradable zinc alloy bracket;
the sealing box is arranged at the end port of the outer ring of the coil pipe, and the left side of the sealing box is communicated with the tail end of the coil pipe;
the conveying device is used for pressing and holding the degradable zinc alloy bracket and loading the degradable zinc alloy bracket into the coil pipe through a three-way valve;
and the vent needle is arranged at an opening at the upper end of the three-way valve and is used for filling gas into the coil pipe.
2. The degradable zinc alloy stent storage device of claim 1, wherein: the end face of the three-way valve, which is vertically assembled with the direction of the vent needle, extends outwards to form a T-shaped cavity structure.
3. The degradable zinc alloy stent storage device of claim 2, wherein: and a drying agent is arranged in the T-shaped cavity body structure of the three-way valve.
4. The degradable zinc alloy stent storage device of claim 1, wherein: the sealing box is internally provided with a sealing ring.
5. A method for storing a degradable zinc alloy stent, which comprises the degradable zinc alloy stent storage device of any one of claims 1 to 4, and is characterized by comprising the following steps:
s1, placing the processed and molded degradable zinc alloy bracket in an air-blast drying box for drying and draining to remove residual cleaning solution;
s2, placing the degradable zinc alloy support dried in the step S1 in an environment with the temperature of 15-25 ℃ and the humidity of 20-30% to be matched with a conveying device for pressing and holding treatment, quickly loading the whole body into a coil pipe from an opening at one side of a three-way valve, and enabling a guide wire at the tail end of the conveying device to penetrate through the sealing box in an opening state to achieve the effect of guide wire clamping;
s3, when the degradable zinc alloy support is loaded, inserting the ventilating needle head in the opening state of the three-way valve, enabling the ventilating needle head to keep a gas-filled state towards the interior of the coil pipe all the time, and enabling the gas in the coil pipe to overflow from the sealing box in the opening state;
s4, closing the three-way valve and the sealing box after loading is finished, pulling out the ventilation needle head, and loading the loaded degradable zinc alloy support and the conveying device into a Tyvek inner packaging bag;
s5, the whole processed in the step S4 is placed into an airtight outer packaging bag packaged with a drying agent, and low-temperature irradiation sterilization is carried out to obtain a finished product.
6. The method for storing the degradable zinc alloy stent according to claim 5, wherein the method comprises the following steps: and in the step S1, the blowing drying box is dried by nitrogen or inert gas.
7. The method for storing the degradable zinc alloy stent according to claim 6, wherein the method comprises the following steps: the drying temperature of the air drying oven does not exceed 40 ℃.
8. The method for storing the degradable zinc alloy stent according to claim 5, wherein the method comprises the following steps: the holding pressure time for the pressing in the step S2 is 20-90 seconds.
9. The method for storing the degradable zinc alloy stent according to claim 5, wherein the method comprises the following steps: the gas filled in the step S3 is nitrogen or inert gas.
10. The method for storing the degradable zinc alloy stent according to claim 6 or 8, wherein the method comprises the following steps: the inert gas is helium or argon.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080010947A1 (en) * | 2006-07-13 | 2008-01-17 | Bin Huang | Reduced temperature sterilization of stents |
| AU2009266390A1 (en) * | 2008-07-04 | 2010-01-07 | Qvanteq Ag | Metal stent for treating lesions in blood vessels, comprising a packaging |
| US20110167764A1 (en) * | 2008-10-08 | 2011-07-14 | Dorn Juergen | Method of transferring a stent device from a crimping head to an outer sheath of a stent device delivery system |
| JP2014090969A (en) * | 2012-11-06 | 2014-05-19 | Kyoto Medical Planning Ltd | Stent feeder |
| CN103879669A (en) * | 2012-12-20 | 2014-06-25 | 上海微创医疗器械（集团）有限公司 | Biodegradable polymer support storing method |
| CN206375189U (en) * | 2017-01-11 | 2017-08-04 | 浩明科技（中山）有限公司 | A kind of chip memory cabinet for preventing controlled silicon chip from aoxidizing |
| CN112830102A (en) * | 2020-12-26 | 2021-05-25 | 云南农业大学 | Tellurium-zinc-cadmium crystal material vacuum storage device |
-
2021
- 2021-06-30 CN CN202110733649.4A patent/CN113371282B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080010947A1 (en) * | 2006-07-13 | 2008-01-17 | Bin Huang | Reduced temperature sterilization of stents |
| AU2009266390A1 (en) * | 2008-07-04 | 2010-01-07 | Qvanteq Ag | Metal stent for treating lesions in blood vessels, comprising a packaging |
| US20110167764A1 (en) * | 2008-10-08 | 2011-07-14 | Dorn Juergen | Method of transferring a stent device from a crimping head to an outer sheath of a stent device delivery system |
| JP2014090969A (en) * | 2012-11-06 | 2014-05-19 | Kyoto Medical Planning Ltd | Stent feeder |
| CN103879669A (en) * | 2012-12-20 | 2014-06-25 | 上海微创医疗器械（集团）有限公司 | Biodegradable polymer support storing method |
| CN206375189U (en) * | 2017-01-11 | 2017-08-04 | 浩明科技（中山）有限公司 | A kind of chip memory cabinet for preventing controlled silicon chip from aoxidizing |
| CN112830102A (en) * | 2020-12-26 | 2021-05-25 | 云南农业大学 | Tellurium-zinc-cadmium crystal material vacuum storage device |
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