CN113358451A

CN113358451A - Novel centrifugal chromatography extractor

Info

Publication number: CN113358451A
Application number: CN202110343481.6A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-03-30
Filing date: 2021-03-30
Publication date: 2021-09-07

Abstract

The application is a novel centrifugal chromatography extractor which is mainly used in the field of separation and purification of compounds. Chromatography is mainly used for laboratory analysis and purification of compounds, but cannot be used for large-scale and continuous preparation. The continuous preparation of organic macromolecules in an industrial purification mode is difficult. The invention improves the chromatography, which makes it suitable for large-scale separation and purification of compounds in industry. The technical scheme is as follows: 1. the liquid mixture passes through a disc-shaped chromatographic column by utilizing centrifugal force (the disc can be filled with solids such as silica sand and the like), different compounds have different filtering speeds in the chromatographic column and can be dispersed at different positions of the disc-shaped chromatographic column, and the compounds are blocked by a grating to be further separated and purified. 2. The liquid with different components is sequentially layered and flows out through the horizontal conduit and the vertical conduit, and is continuously prepared by rotary centrifugation. Various liquid-soluble compounds, especially macromolecular organic compounds, can be isolated and purified.

Description

Novel centrifugal chromatography extractor

Technical Field

And (4) separating and purifying the compound.

Background

The chromatography is mainly used for analyzing and extracting pure compounds in a laboratory, is quick and convenient, but cannot be prepared in large quantity and continuously, and sometimes, the experimental result cannot be completely reproduced and is inconvenient. In the industrial purification mode of organic macromolecules, chemical methods have more steps, and the physical methods include chromatography, ultrafiltration, electrophoresis, adsorption and the like, so that the continuous preparation is difficult. The invention improves the chromatography, which is suitable for separating and purifying compounds in large quantity in industry.

Disclosure of Invention

The invention relates to a novel centrifugal chromatography extractor, which is shown in a disc device in figure 1, utilizes centrifugal force to enable a liquid mixture to pass through a disc-shaped chromatography column in a disc (the disc can be filled with solids such as silica sand) and the like), utilizes different compounds with different filtering speeds in the chromatography column to be dispersed at different positions of the disc-shaped chromatography column, then utilizes a grating for blocking, further separates and purifies the compounds by a plurality of stages of gratings (shown in figures 1, 2 and 3 in the specification), finally enters a guide pipe at the tail end of the disc through a guide hole to flow into a liquid collector device (shown in figure 5 in the specification), does not rotate in the centrifugal process of the device, finally collects liquid of one guide pipe through one hole in each layer, respectively collects the liquid of different 20 holes (shown in figure 6 in the specification), and finally achieves the separation and purification effects, the device can feed liquid continuously, can be connected in series by a plurality of devices, further separates and purifies, and can realize the effect of a large amount of separation and purification. In addition, the device has the effect of continuous separation and purification of various high molecular compounds of the same type with different molecular sizes, and achieves better separation and purification effects.

The centrifugal chromatography extractor mainly comprises three parts.

First, a circular cover. The device is composed of a disc-shaped cover with a liquid inlet hole, the disc-shaped cover is mainly used for sealing a disc below the liquid inlet hole, a liquid inlet pipe can be connected to the upper portion of the liquid inlet hole through a bearing, the device rotates, a pipe above the liquid inlet hole does not rotate, and liquid can be continuously fed. The apparatus is shown in figure 3.

And II, a disc. The device consists of a grid, liquid guide holes, a disc, an edge fence, a rotating column, a hexagonal fixing column, a liquid guide pipe and a filling area. Through the effect of the mixed liquid that comes under the top feed liquor hole through the centrifugal force, because different molecular diffusion velocity is inconsistent, can be blockked by different grids respectively to separate, finally get into the pipe at terminal drain hole, because the diameter of column spinner is great, and there is the action of gravity, can follow other one end drain hole behind the liquid entering catheter and flow out. The position of each flow guide hole is staggered with a certain distance from the position of the previous flow guide hole. An electric motor can be connected below the hexagonal fixed column and used for the rotary operation of the device. The device is shown in figures 1 and 2.

And thirdly, a circular flow guide pipe. The honeycomb duct is shorter, is distributed on the honeycomb duct of the rotary column in a rotating step mode, and has a certain distance between every two honeycomb ducts. As shown in fig. 6.

And thirdly, a liquid collector. The device is formed by a plurality of layers of annular grids, the horizontal part can accommodate a guide pipe to rotate in the space all the time, the upper disk inclined part can collect the flowing liquid by utilizing gravity and finally flow out through the guide holes outside the liquid collector, the device is not moved in operation, and each hole can be connected with the guide pipe to collect the separated and purified liquid. The device is shown in fig. 4 and 5.

The structure of the centrifugal chromatography extractor is shown in FIGS. 6 and 7.

Drawings

FIG. 1: the figure is a top view of a rotating disk of a centrifugal chromatography extractor.

FIG. 2: this figure is a diagram of the structure of the rotating disk of the centrifugal chromatography extractor.

FIG. 3: this figure is a front view of a lidded disk of a centrifugal chromatography extractor.

FIG. 4: this figure is a cross-sectional view of the liquid trap of a centrifugal chromatography extractor.

FIG. 5: this figure is a front view of the liquid trap of a centrifugal chromatography extractor.

FIG. 6: this figure is a structural view of a centrifugal chromatography extractor.

FIG. 7: this figure shows the effect of the completion of the assembly of the centrifugal chromatography extractor.

Claims

1. A centrifugal chromatography extractor device, characterized by: contained closed discoid chromatography column device, discoid chromatography column device middle contains the grid that multistage different inclination placed, can the different liquid of purification in grades during centrifugal chromatography, the terminal drain hole of disc has connected the catheter of attaching to on the column spinner, the terminal rotatory cascaded drainage hole of opening of catheter connects the honeycomb duct, it is rotatory in layers, collect through annular liquid collector, each layer of outer tip downward sloping of liquid collector, utilize gravity to collect liquid, each layer of trompil of liquid collector, the liquid that the hole of each layer flows is collected with different containers, finally obtain the compound after the separation purification.

2. A disc centrifuge chromatograph device, characterized in that: the device consists of a grid, liquid guide holes, a disc, an edge fence, a rotating column, a hexagonal fixing column, a liquid guide pipe and a filling area.

3. The discoid container, there is different inclination's grid the inside, can fill the required material of chromatography, the disc edge is the rampart, has the water conservancy diversion hole to make liquid flow out the disc get into the below pipe in the wall, and the pipe is attached to on the column spinner, rotates along with the column spinner, because the effect of centrifugal force and gravity, the water conservancy diversion hole outflow on liquid passes through the column spinner, and this water conservancy diversion hole rotatory cascaded distributes on the column spinner, can the layering outflow liquid.

4. An annular liquid trap assembly, comprising: the device is formed by a plurality of layers of annular grids, the horizontal part can accommodate a guide pipe to rotate in the space all the time, the upper disk inclined part can collect the flowing liquid by utilizing gravity and finally flow out through the guide holes outside the liquid collector, the device is not moved in operation, and each hole can be connected with the guide pipe to collect the separated and purified liquid.

5. The utility model provides a discoid chromatography column grid device which characterized in that: in the flat columnar disc, a plurality of grids are uniformly arranged on the circumference, materials such as silica sand and the like can be placed in the disc to form a flat chromatographic column, and the mixture flows into different flow guide holes by different grids due to the inconsistent speed of the chromatographic column principle.

6. A disc honeycomb duct device which characterized in that: the terminal water conservancy diversion hole of disc drainage disc terminal liquid flow direction water conservancy diversion hole on the column spinner, the rotatory cascaded distribution of water conservancy diversion hole on the column spinner, and each terminal water conservancy diversion hole of vertical direction all monopolizes one deck space.

7. The utility model provides an annular liquid trap outer end tilting gearing which characterized in that: the outer end of the annular liquid collector has a downward inclined angle, and liquid can flow down along the slope due to gravity and flow out through the flow guide holes in the wall of each layer of the liquid collector.

8. A liquid inlet device, which is characterized in that: liquid enters the disc through the upper flow guide pipe, flows to the periphery from the inner column material of the disc due to centrifugal force, and liquid in the liquid inlet can be appointed to enter the disc chromatographic column from one direction or a plurality of directions from top to bottom to the inside-out process.