CN113354912A - Tracheotomy tube body and preparation process thereof - Google Patents
Tracheotomy tube body and preparation process thereof Download PDFInfo
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- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
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Abstract
The application relates to the technical field of tracheal surgical instruments, in particular to a tracheotomy tube body and a preparation method thereof. A tracheotomy tube body comprises the following components in parts by weight: 100 portions and 150 portions of polyvinyl chloride resin; 20-50 parts of a plasticizer; 5-10 parts of a stabilizer; 200 portions of modified polyvinyl chloride and 250 portions of modified polyvinyl chloride; the preparation steps of the modified polyvinyl chloride are as follows: a. modification treatment: heating and mixing polyvinyl chloride resin, modified emulsion and an initiator to prepare a modified material; the modified emulsion consists of tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane; b. softening treatment: and heating and mixing the modified material, the lubricant and the surfactant to prepare the modified polyvinyl chloride. The utility model provides a tracheotomy tube body has good pliability, and it is difficult after inserting the trachea to cause the damage to the endotracheal mucosa, and the comfort level is higher.
Description
Technical Field
The application relates to the technical field of tracheal surgical instruments, in particular to a tracheotomy tube body and a preparation method thereof.
Background
In respiratory diseases, patients suffering from respiratory difficulties caused by laryngeal dyspnea, respiratory dysfunction or lower respiratory secretions retention are often treated by tracheotomy. Tracheotomy, namely, a tracheotomy tube is placed after a neck trachea is cut, and a respiratory passage is provided for an adult patient needing anesthesia, artificial ventilation or other auxiliary respiration through the tracheotomy tube.
The tracheotomy tube in the related technology comprises a tube body made of polyvinyl chloride through processes of mixing, extruding, injection molding, blow molding and the like, wherein one end of the tube body is connected with a plug-in pipe joint for connecting external equipment, and the other end of the tube body can be used after being inserted into the trachea of a patient.
The body hardness in the above-mentioned technique is great, and after inserting the trachea, because the respiratory tract does not keep warm through the throat and moisturize, self breathing increases more easily and leads to a large amount of moisture to lose, then can cause certain damage and comfort level relatively poor to the endotracheal mucosa.
Disclosure of Invention
In order to guarantee the comfort degree of the tube body when the trachea is inserted and not easily cause damage to the mucosa in the trachea, the application provides the tracheotomy tube body and the preparation method thereof.
First aspect, the application provides a tracheotomy tube body, adopts following technical scheme:
a tracheotomy tube body comprises the following components in parts by weight:
100 portions of polyvinyl chloride resin and 150 portions of
20-50 parts of a plasticizer;
5-10 parts of a stabilizer;
200 portions of modified polyvinyl chloride and 250 portions of modified polyvinyl chloride;
the preparation steps of the modified polyvinyl chloride are as follows:
a. modification treatment: mixing polyvinyl chloride resin, modified emulsion and initiator at 80-100 ℃ for 5-10min, and then mixing in vacuum at 180-200 ℃ for 4-5h to prepare a modified material;
the modified emulsion consists of tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane;
b. softening treatment: mixing the modified material, the lubricant and the surfactant at the temperature of 80-100 ℃ for 1-2h to prepare the modified polyvinyl chloride.
By adopting the technical scheme, the prepared tracheotomy tube body is high in flexibility, not easy to damage the endotracheal mucosa and high in comfort level, and presumably the reason is that polyvinyl chloride resin is initiated by an initiator when being mixed and heated with a modifying liquid, the polyvinyl chloride resin is used as a net-shaped structure framework, and a composite net layer structure with a silica gel film is formed among the net-shaped polyvinyl chloride resin in a filling manner, the composite net layer structure can be fully dispersed and combined with the polyvinyl chloride resin after being treated by a lubricant and a surfactant, the composite net layers can be displaced and compressed in a small amplitude when being mutually overlapped in a staggered manner, so that the tracheotomy tube body is endowed with excellent flexibility and low Shore hardness.
Preferably, the modified emulsion in a is prepared by mixing tributyl citrate, tetramethyltetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: (0.02-0.04): (2-3).
By adopting the technical scheme, after the tributyl citrate, the tetramethyltetravinylcyclotetrasiloxane and the octamethylcyclotetrasiloxane in the proportion are initiated by the initiator, the formed silica gel film has good dispersibility and flexibility, and can be combined with a net-shaped structure skeleton formed by polyvinyl chloride resin to endow the tracheotomy tube body with better flexibility and lower Shore hardness.
Preferably, the polyvinyl chloride resin, the modified emulsion and the initiator in the step a are mixed according to a weight ratio of 1: (0.2-0.3) and (0.01-0.02).
By adopting the technical scheme, the polyvinyl chloride resin, the modified emulsion and the initiator which are proportioned in the above ratio have good combined filling effect, the initiator has good initiating effect, the formed silica gel film can be fully combined with a net-shaped structure skeleton, the branching degree of the formed composite net-shaped structure and the filling property of the silica gel film are good, the trachea incision cannula body is endowed with excellent flexibility, and the Shore hardness is low.
Preferably, the initiator in a is composed of one or more of sodium trimethylsilanolate and methyltriacetoxysilane.
By adopting the technical scheme, the component initiator has a large number of weak bonds which are easily decomposed into active bonding groups, a large number of free radicals are released by the breakage of the weak bonds in the reaction process, and the polymerization reaction is initiated, so that the silica gel film can be rapidly synthesized while the initiation effect is good, and the bonding strength between the silica gel film and the net-shaped framework is further enhanced.
Preferably, the weight ratio of the modifier to the lubricant and the surfactant in b is 1: (0.2-0.3): (0.1-0.2).
By adopting the technical scheme, the modified material, the lubricant and the surfactant in the ratio have good structural dispersibility and flowability of the formed composite net layer, and the formed composite net layer can be fully combined with polyvinyl chloride resin, and meanwhile, the net layers which are mutually staggered, overlapped and compounded have micro-displacement and micro-deformation capacity, so that the tracheotomy tube body is endowed with excellent flexibility, and the Shore hardness is low.
Preferably, the lubricant in b is composed of one or more of calcium stearate and zinc stearate.
By adopting the technical scheme, the lubricating agent of the component has a good lubricating effect, is green and non-toxic, gives good dispersibility and fluidity to the composite net layer structure, and ensures the flexibility of the pipe body through small-amplitude displacement and slight compression between the layered structures after being combined with the polyvinyl chloride resin, and the Shore hardness is low.
Preferably, the surfactant in b consists of one or more of coconut diethanolamide and succinate sulfonate.
By adopting the technical scheme, the surfactant of the component has a good improvement effect on the fluidity among the components, is green and non-toxic, and can endow a pipe body with better flexibility and lower Shore hardness through small-amplitude displacement and slight compression among layered structures when being combined with polyvinyl chloride resin.
Preferably, the plasticizer is composed of one or more of glyceryl triacetate and di-n-octyl phthalate, and by adopting the technical scheme, the plasticizer of the component contains more active groups capable of being combined with the composite net layer structure and resin, so that the dispersity and the flowability among the components are obviously improved, and more compression gaps and displacement allowance exist among the staggered and overlapped composite net layers, and further, the trachea cannula cutting tube body is endowed with excellent flexibility.
Preferably, the stabilizer consists of one or more of a liquid calcium zinc stabilizer and organotin.
By adopting the technical scheme, the stabilizer of the components has good processing performance, is non-toxic and harmless, can remarkably improve the stability and the plasticizing fluidity among the components, and can reduce the softening point of the tube body, thereby endowing the tracheotomy tube body with excellent flexibility.
In a second aspect, the present application provides a method for preparing a tracheotomy tube body, which adopts the following technical scheme: a preparation method of a tracheotomy tube body comprises the following steps:
s1, mixing the raw materials: after the raw materials are subjected to ultrasonic cleaning, mixing the components according to the corresponding weight to prepare a mixture;
s2, injection molding: and heating and melting the mixture, injecting the mixture into a mold, performing mold closing, air exhaust and pressure maintaining treatment, heating and sintering, cooling to room temperature, and taking out from the mold to obtain the tracheotomy tube body.
By adopting the technical scheme, the preparation steps are simple, various conditions are easy to control and achieve, industrial production is facilitated, and the prepared tracheotomy intubation tube body is stable in performance and has excellent flexibility.
In summary, the present application has the following beneficial effects:
1. the composite mesh layer structure is formed by the reticular polyvinyl chloride resin and the silica gel film filled between the reticular structures, and after the composite mesh layer structure is treated by the lubricant and the surfactant, the composite mesh layer structure can be mutually staggered and overlapped and can be displaced and compressed in a small amplitude, so that the tracheotomy tube body is endowed with excellent flexibility and lower Shore hardness;
2. the fluidity between the composite net layers is obviously improved by using the plasticizer, and more compression gaps and displacement allowance exist between the staggered and overlapped composite net layers, so that the flexibility of the tracheotomy tube body is guaranteed;
3. the preparation step in this application is simple and easy, and when each item condition easily reached, the tracheotomy tube body stable performance who makes all has good pliability, is applicable to the industrial production then.
Detailed Description
The present application will be described in further detail with reference to examples.
The raw materials used in the examples of the present application are commercially available, except for the following specific descriptions:
polyvinyl chloride resin, CAS 9002-86-2, purchased from Jinan Huiyuan Sichuan chemical Co., Ltd;
tributyl citrate, CAS 77-94-1, available from Cian blue Jazz, commerce, Inc.;
tetramethyltetravinylcyclotetrasiloxane, CAS No. 27342-69-4, available from Hubei Xin run chemical Co., Ltd;
octamethylcyclotetrasiloxane, CAS 556-67-2, available from chemical Co., Ltd, King Kogyo, Ching, Kogyo, Ji nan;
sodium trimethylsilanolate, CAS number 1233542-32-9, purchased from Shanghai landscape chemical Co., Ltd;
methyltriacetoxysilane, CAS 4253-34-3, available from Condites chemical (Hubei) Inc.;
calcium stearate, CAS 1592-23-0, purchased from Nanjing Jinling chemical plant, Inc.;
zinc stearate, CAS 557-05-1, purchased from Shandong Whishengtang Bio-pharmaceutical Co., Ltd;
cocoanut diethanolamide, CAS 68603-42-9, purchased from Jining Sanshi Biotech Ltd;
sodium sulfosuccinate, CAS 577-11-7, available from Nantong Chen Runji chemical Co., Ltd;
glyceryl triacetate, CAS 102-76-1, available from Nature chemical Co., Ltd, Yixing City;
di-n-octyl phthalate, CAS 117-84-0, available from Xinming Titai chemical Co., Hubei;
liquid calcium zinc stabilizer, HY-501, purchased from Shanghai Hua sparkling chemical auxiliary agent, Inc.;
organotin, T-580, purchased from shanghai zhiqiang plastics additives ltd;
an ultrasonic cleaning machine, model KPDR-QC 2030-25A;
horizontal injection molding machine, model SA600/100 u.
Preparation example
Preparation example 1
The preparation method of the modified polyvinyl chloride comprises the following steps:
a. modification treatment: firstly, polyvinyl chloride resin, modified emulsion and initiator are mixed according to the weight ratio of 1: 0.1: 0.005 mixing, namely stirring for 5min at the rotating speed of 80r/min at the temperature of 80 ℃, then heating to 180 ℃, and stirring for 4h at the rotating speed of 200r/min under the vacuum condition to prepare a modified material;
the modified emulsion is prepared from tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: 0.01: 1, preparing a composition;
the initiator is sodium trimethylsilanolate;
b. softening treatment: modifying materials, lubricating agents and surfactants according to the weight ratio of 1: 0.1: 0.05 mixing, namely stirring for 1h at the rotating speed of 80r/min at the temperature of 80 ℃ to prepare the modified polyvinyl chloride.
The lubricant is calcium stearate;
the surfactant is coconut diethanolamide.
Preparation example 2
The modified polyvinyl chloride is different from the preparation example 1 in that the preparation steps are as follows:
a. modification treatment: firstly, stirring polyvinyl chloride resin, modified emulsion and an initiator at the rotation speed of 80r/min for 7.5min at the temperature of 90 ℃, then heating to 190 ℃, and stirring at the rotation speed of 200r/min for 4.5h under the vacuum condition to prepare a modified material;
b. softening treatment: and stirring the modified material, the lubricant and the surfactant for 1.5 hours at the rotation speed of 80r/min at the temperature of 90 ℃ to prepare the modified polyvinyl chloride.
Preparation example 3
The modified polyvinyl chloride is different from the preparation example 1 in that the preparation steps are as follows:
a. modification treatment: firstly, stirring polyvinyl chloride resin, modified emulsion and an initiator at the rotation speed of 80r/min for 10min at the temperature of 100 ℃, then heating to 200 ℃, and stirring at the rotation speed of 200r/min for 5h under the vacuum condition to prepare a modified material;
b. softening treatment: and stirring the modified material, the lubricant and the surfactant for 2 hours at the rotating speed of 80r/min at the temperature of 100 ℃ to prepare the modified polyvinyl chloride.
Preparation example 4
The modified polyvinyl chloride is different from the preparation example 1 in that the polyvinyl chloride resin, the modified emulsion and the initiator in the weight ratio of (a) is 1: 0.2: 0.01 mixing.
Preparation example 5
The modified polyvinyl chloride is different from the preparation example 1 in that the polyvinyl chloride resin, the modified emulsion and the initiator in the weight ratio of (a) is 1: 0.25: 0.015 mixing.
Preparation example 6
The modified polyvinyl chloride is different from the preparation example 1 in that the polyvinyl chloride resin, the modified emulsion and the initiator in the weight ratio of (a) is 1: 0.3: 0.02 mixing.
Preparation example 7
The modified polyvinyl chloride is different from the preparation example 1 in that the polyvinyl chloride resin, the modified emulsion and the initiator in the weight ratio of (a) is 1: 0.4: 0.025 and mixing.
Preparation example 8
A modified polyvinyl chloride, which is different from the modified polyvinyl chloride prepared in preparation example 1 in that the modified emulsion in the step a is prepared by mixing tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: 0.02: 2.
Preparation example 9
A modified polyvinyl chloride, which is different from the modified polyvinyl chloride prepared in preparation example 1 in that the modified emulsion in the step a is prepared by mixing tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: 0.03: 2.5.
Preparation example 10
A modified polyvinyl chloride, which is different from the modified polyvinyl chloride prepared in preparation example 1 in that the modified emulsion in the step a is prepared by mixing tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: 0.04: 3, and (3).
Preparation example 11
A modified polyvinyl chloride, which is different from the modified polyvinyl chloride prepared in preparation example 1 in that the modified emulsion in the step a is prepared by mixing tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: 0.05: 4.
Preparation example 12
A modified polyvinyl chloride is distinguished from preparation example 1 in that the initiator is methyltriacetoxysilane.
Preparation example 13
A modified polyvinyl chloride was distinguished from preparation example 1 in that the initiator consists of sodium trimethylsilanolate and methyltriacetoxysilane in a weight ratio of 1: 1.
Preparation example 14
The modified polyvinyl chloride is different from the preparation example 1 in that the weight ratio of the modifying material to the lubricant and the surfactant in the step b is 1: 0.2: 0.1.
Preparation example 15
The modified polyvinyl chloride is different from the preparation example 1 in that the weight ratio of the modifying material to the lubricant and the surfactant in the step b is 1: 0.25: 0.15.
Preparation example 16
The modified polyvinyl chloride is different from the preparation example 1 in that the weight ratio of the modifying material to the lubricant and the surfactant in the step b is 1: 0.3: 0.2.
Preparation example 17
The modified polyvinyl chloride is different from the preparation example 1 in that the weight ratio of the modifying material to the lubricant and the surfactant in the step b is 1: 0.4: 0.25.
Preparation example 18
A modified polyvinyl chloride, which is different from the preparation example 1 in that the lubricant in the b is zinc stearate.
Preparation example 19
A modified polyvinyl chloride is different from the modified polyvinyl chloride prepared in preparation example 1 in that a lubricant in b is composed of calcium stearate and zinc stearate in a weight ratio of 1: 1.
Preparation example 20
A modified polyvinyl chloride, which is different from preparation example 1 in that the surfactant in b is succinate sulfonate, preferably sodium succinate sulfonate.
Preparation example 21
A modified polyvinyl chloride, which is different from the preparation example 1 in that in the step b, the surfactant consists of coconut diethanolamide and succinate sulfonate in a weight ratio of 1: 1;
the succinate sulfonate is sodium succinate sulfonate.
Examples
Example 1
A tracheostomy tube body, the components and their respective weights are shown in Table 1 and prepared by the steps of:
s1, mixing the raw materials: firstly, putting polyvinyl chloride resin and modified polyvinyl chloride into an ultrasonic cleaning machine for cleaning for 10min, and then mixing the polyvinyl chloride resin, the modified polyvinyl chloride, a plasticizer and a stabilizer according to the corresponding weight at 500r/min for 10min to prepare a mixture;
the plasticizer is glyceryl triacetate;
the stabilizer is a liquid calcium zinc stabilizer;
s2, injection molding: heating the mixture to 200 ℃ for melting, injecting the mixture into a mold in a horizontal injection molding machine, applying pressure of 45Mpa for mold closing, exhausting for 5 times, controlling pressure of 20Mpa for pressure maintaining treatment for 60min, heating to 250 ℃, sintering for 2, and cooling to room temperature to obtain the tracheotomy tube body.
Examples 2 to 6
A tracheostomy tube body differing from example 1 in that the components and their respective weights are as shown in table 1.
TABLE 1 Components and weights (kg) thereof in examples 1-6
Examples 7 to 26
A tracheotomy tube body, which is different from the tube body of the tracheotomy tube in example 1 in that the modified polyvinyl chloride is used in different conditions, and the specific corresponding relationship is shown in table 2.
TABLE 2 comparison of the usage of modified polyvinyl chloride in examples 7-26
| Group of | Modified polyvinyl chloride |
| Example 7 | Prepared from preparation example 2 |
| Example 8 | Prepared from preparation example 3 |
| Example 9 | Prepared from preparation example 4 |
| Example 10 | Prepared from preparation example 5 |
| Example 11 | Prepared from preparation example 6 |
| Example 12 | Prepared from preparation example 7 |
| Example 13 | Prepared from preparation example 8 |
| Example 14 | Prepared from preparation example 9 |
| Example 15 | Prepared from preparation example 10 |
| Example 16 | Prepared from preparation example 11 |
| Example 17 | Prepared from preparation example 12 |
| Example 18 | Prepared from preparation example 13 |
| Example 19 | Prepared from preparation 14 |
| Example 20 | Prepared from preparation example 15 |
| Example 21 | Prepared from preparation example 16 |
| Examples22 | Prepared from preparation example 17 |
| Example 23 | Prepared from preparation 18 |
| Example 24 | Prepared from preparation example 19 |
| Example 25 | Prepared from preparation example 20 |
| Example 26 | Prepared from preparation example 21 |
Example 27
A tracheostomy tube body differing from that of example 1 in that the plasticizer is di-n-octyl phthalate.
Example 28
A tracheostomy tube body differing from example 1 in that the plasticizer consists of glyceryl triacetate and di-n-octyl phthalate in a weight ratio of 1: 1.
Example 29
A tracheostomy tube body, which differs from example 1 in that the stabilizer is organotin.
Example 30
A tracheostomy tube body, which differs from example 1 in that the stabilizer consists of a liquid calcium zinc stabilizer and organotin in a weight ratio of 1: 1.
Comparative example
Comparative example 1
A tracheostomy tube body which differs from that of example 1 in that polyvinyl chloride is not modified.
Comparative example 2
A tracheostomy tube body, differing from example 1 in that modified polyvinyl chloride was prepared by the following steps: a. Modification treatment: firstly, stirring polyvinyl chloride resin, modified emulsion and an initiator at the rotation speed of 80r/min for 2.5min at the temperature of 60 ℃, then heating to 160 ℃, and stirring for 3h at the rotation speed of 200r/min under the vacuum condition to prepare a modified material; b. Softening treatment: and stirring the modified material, the lubricant and the surfactant at the temperature of 60 ℃ for 0.5h at the rotating speed of 80r/min to prepare the modified polyvinyl chloride.
Comparative example 3
A tracheostomy tube body, differing from example 1 in that modified polyvinyl chloride was prepared by the following steps: a. Modification treatment: firstly, stirring polyvinyl chloride resin, modified emulsion and an initiator at the temperature of 120 ℃ for 12.5min at the rotating speed of 80r/min, then heating to 220 ℃, and stirring for 6h at the rotating speed of 200r/min under the vacuum condition to prepare a modified material; b. Softening treatment: and stirring the modified material, the lubricant and the surfactant for 2.5 hours at the rotating speed of 80r/min at the temperature of 120 ℃ to prepare the modified polyvinyl chloride.
Comparative example 4
A tracheostomy tube body differing from that of example 1 in that the modified emulsion did not contain tributyl citrate.
Comparative example 5
A tracheostomy tube body as in example 1 except that the modified emulsion did not contain tetramethyltetravinylcyclotetrasiloxane.
Comparative example 6
A tracheostomy tube body differing from that of example 1 in that the modified emulsion contained no octamethylcyclotetrasiloxane.
Comparative example 7
A tracheostomy tube body as in example 1 except that the modified emulsion did not contain tributyl citrate and tetramethyltetravinylcyclotetrasiloxane.
Comparative example 8
A tracheostomy tube body as in example 1 except that the modified emulsion was free of tributyl citrate and octamethylcyclotetrasiloxane.
Comparative example 9
A tracheostomy tube body as in example 1 except that the modified emulsion did not contain tetramethyltetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane.
Performance test
The tracheostomy tube bodies prepared in examples 1 to 30 and comparative examples 1 to 9 were selected as test objects, the tensile strength and elongation at break were respectively tested, a shore hardness tester a was selected to test the shore hardness, and the test results are shown in table 3. The concrete detection steps and detection standards refer to GB/T1039-.
Table 3 results of performance testing
Combining examples 1-6, comparative example 1 and Table 3, it can be seen that examples 1-6 all have Shore hardnesses no higher than 80, tensile strengths no higher than 35MPa, and elongations at break all higher than 360%.
The embodiment 3 is the best embodiment, the Shore hardness is 72, the tensile strength is 31.4MPa, and the breaking elongation can reach 398%. Therefore, the modified tracheotomy tube body prepared by the components according to the proportion has lower Shore hardness, better flexibility, less possibility of damaging the mucosa in the trachea and stronger comfort level.
In comparative example 1, since no modified polyvinyl chloride was used, the Shore hardness was as high as 87, the tensile strength was only 38.9MPa, and the elongation at break was only 317%.
To sum up, for the silica gel film of network structure skeleton cooperation filling formation between the skeleton through polyvinyl chloride, constituted composite net layer structure jointly, composite net layer structure combines the back with polyvinyl chloride resin fully dispersed, can little amplitude displacement and compression, has then given the better pliability of tracheotomy tube body, and shore hardness is lower.
Combining example 1, examples 7-8, comparative examples 2-3 and combining Table 3, it can be seen that examples 7-8 all had Shore hardnesses higher than 75, tensile strengths higher than 35MPa, and elongations at break higher than 360%.
Example 7 is the most preferred example, with a Shore hardness of 74, tensile strength of 34.4MPa, and elongation at break of 367%. Therefore, the process in preparation example 2 is the optimal process, and the modified polyvinyl chloride prepared under the parameter condition has good improvement effect on the flexibility of the tracheotomy tube body.
The modified tracheotomy tube body prepared by adopting the process conditions in the comparative examples 2-3 has higher Shore hardness and poorer flexibility, the Shore hardness is higher than 78, the tensile strength is higher than 35.0Mpa, and the elongation at break is not higher than 330%.
Combining example 1, examples 9-12 and table 3, it can be seen that examples 9-12 all have shore hardness no higher than 75, tensile strength no higher than 35Mpa, and elongation at break no higher than 370%.
Example 10 is the best example, the shore hardness is only 71, the tensile strength is 29.8Mpa, and the breaking tensile rate can reach 412%, and it can be seen that the distribution ratio of the components in preparation example 5 is the best condition.
In summary, when the weight ratio of the polyvinyl chloride resin, the modified emulsion and the initiator in the step a is 1: 0.25: 0.015 when mixing, it combines to fill the effect best, and the silica gel film that forms can fully combine with network structure skeleton, has ensured the branching degree and the silica gel film fillibility of compound stratum reticulare structure then, has given tracheotomy tube body better pliability and comfort level, is difficult for causing the damage to the endotracheal mucosa after inserting the trachea.
Combining examples 1, 13-16, and 4-9 with Table 3, it can be seen that examples 7-8 all had Shore hardnesses higher than 73, tensile strengths higher than 33MPa, and elongations at break higher than 370%.
The example 10 is the best example, the shore hardness is 71, the tensile strength is 28.7Mpa, and the breaking elongation can reach 415%, so that the proportion of the modified emulsion in the preparation example 9 is the best proportion.
The modified emulsion prepared in the comparative examples 4 to 9 has relatively poor modification effect of the modified polyvinyl chloride because three components are not added simultaneously, so that the Shore hardness of the pipe body is higher, the overall flexibility is poor, the Shore hardness is higher than 80, the tensile strength is higher than 38.9MPa, and the elongation at break is lower than 330%.
In conclusion, the three components have a synergistic effect, and the weight ratio of the three components is 1: 0.03: 2.5 when the materials are mixed, the synergistic effect is strongest, and the formed silica gel film has optimal dispersity and softness, so that the flexibility of the tracheotomy tube body can be obviously improved.
Combining example 1, examples 17-18 and table 3, it can be seen that examples 17-18 all have Shore hardnesses higher than 75, tensile strengths higher than 34.5MPa and elongations at break higher than 360%. Example 17 is the best example, and its shore hardness is only 74, tensile strength is 32.6Mpa, and elongation at break can reach 385%, and it can be seen that the initiation effect is better when two components are used in preparation example 13.
In conclusion, when the initiator consists of sodium trimethylsilanolate and methyltriacetoxysilane according to the weight ratio of 1:1, the sodium trimethylsilanolate and the methyltriacetoxysilane have certain compounding effect, release more free radicals, have stronger binding force, have better initiation effect, and can be quickly and stably combined between the silica gel film and the net-shaped framework.
Combining example 1, examples 19-22 and table 3, it can be seen that examples 19-22 all have shore hardness no higher than 75, tensile strength no higher than 34Mpa, and elongation at break no higher than 370%.
Example 20 is the most preferred example, and has a shore hardness of 73, a tensile strength of 31.8Mpa, and a tensile rate at break of 392%, which indicates that the component ratio in preparation example 15 is the most preferred condition.
In conclusion, when the modifying material in the b, the lubricant and the surfactant are mixed according to the weight ratio of 1: 0.25: 0.15 when mixed, the formed composite net layer structure has the best dispersibility and flowability, and has the micro-displacement and micro-deformation capabilities, so that the tracheotomy tube body is endowed with better softness and lower Shore hardness.
Combining example 1, examples 23-24 and table 3, it can be seen that examples 23-24 have shore hardness not higher than 76, tensile strength not higher than 34.5Mpa, and elongation at break not higher than 360%. Among them, example 24 is the most preferable example, and has a shore hardness of only 75, a tensile strength of 33.6Mpa, and a breaking elongation of 375%, which indicates that the lubricating effect is the best when two components are used in preparation example 19.
In conclusion, when the lubricant consists of calcium stearate and zinc stearate according to the weight ratio of 1:1, the calcium stearate and the zinc stearate have a matching effect, the lubricating effect is good, the green and non-toxic effects are achieved, the composite mesh layer structure is endowed with excellent dispersibility and flowability, and the flexibility of the pipe body is further guaranteed.
Combining example 1, examples 25-26 and table 3, it can be seen that examples 25-26 all have shore hardness no higher than 76, tensile strength no higher than 35Mpa, and elongation at break no higher than 365%. Example 26 is the most preferred example, with a shore hardness of only 75, a tensile strength of 33.7Mpa, and a tensile elongation at break of 376%, which indicates that the best softening effect is achieved when two components are used in preparation example 21.
In conclusion, when the surfactant consists of the coconut diethanolamide and the sodium sulfosuccinate in a weight ratio of 1:1, the two have a matching effect, the improvement effect on the fluidity of the components is better, and the surfactant is green and non-toxic, so that the pipe body is endowed with better flexibility.
Combining example 1, examples 27-28 and Table 3, it can be seen that examples 27-28 all have Shore hardnesses higher than 75, tensile strengths higher than 34MPa, and elongations at break higher than 375%. The embodiment 28 is the best embodiment, the Shore hardness is only 73, the tensile strength is 32.2MPa, and the breaking elongation can reach 391%.
In summary, when the plasticizer is prepared from glyceryl triacetate and di-n-octyl phthalate in a weight ratio of 1:1, the two components have a compounding effect, contain more active groups, can be fully combined with a composite net layer structure, obviously improve the dispersibility and the fluidity among the components, and further endow the tracheotomy tube body with better softness.
Combining example 1, examples 29-30 and table 3, it can be seen that examples 29-30 all have shore hardness no higher than 75, tensile strength no higher than 35Mpa, and elongation at break no higher than 365%. The embodiment 30 is the best embodiment, the Shore hardness is only 74, the tensile strength is 34.4MPa, and the breaking elongation can reach 370%.
In conclusion, when the stabilizer consists of the liquid calcium zinc stabilizer and the organic tin according to the weight ratio of 1:1, the softening point and the Shore hardness of the tube body can be reduced, and then the tube body of the tracheotomy tube is endowed with excellent flexibility.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The utility model provides a tracheotomy tube body which characterized in that, includes the following components by weight:
100 portions of polyvinyl chloride resin and 150 portions of
20-50 parts of a plasticizer;
5-10 parts of a stabilizer;
200 portions of modified polyvinyl chloride and 250 portions of modified polyvinyl chloride;
the preparation steps of the modified polyvinyl chloride are as follows:
a. modification treatment: mixing polyvinyl chloride resin, modified emulsion and initiator at 80-100 ℃ for 5-10min, and then mixing in vacuum at 180-200 ℃ for 4-5h to prepare a modified material;
the modified emulsion consists of tributyl citrate, tetramethyl tetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane;
b. softening treatment: mixing the modified material, the lubricant and the surfactant at the temperature of 80-100 ℃ for 1-2h to prepare the modified polyvinyl chloride.
2. The tracheostomy tube body of claim 1 wherein said modified emulsion in a is prepared from tributyl citrate, tetramethyltetravinylcyclotetrasiloxane and octamethylcyclotetrasiloxane in a weight ratio of 1: (0.02-0.04): (2-3).
3. The tracheostomy tube body of claim 1 wherein the polyvinyl chloride resin, modified emulsion and initiator in a are present in a weight ratio of 1: (0.2-0.3) and (0.01-0.02).
4. The tracheostomy tube body of claim 1 wherein said initiator in a is comprised of one or more of sodium trimethylsilanolate, methyltriacetoxysilane.
5. The tracheostomy tube body of claim 1 wherein the modifier in b is mixed with a lubricant and surfactant in a weight ratio of 1: (0.2-0.3): (0.1-0.2).
6. The tracheostomy tube body of claim 1 wherein said lubricant in b is comprised of one or more of calcium stearate and zinc stearate.
7. The tracheostomy tube body of claim 1 wherein said surfactant in b consists of one or more of cocodiethanolamide and succinate sulfonate.
8. The tracheostomy tube body of claim 1, wherein the plasticizer is comprised of one or more of glyceryl triacetate and di-n-octyl phthalate.
9. The tracheostomy tube body of claim 1, wherein the stabilizer is comprised of one or more of a liquid calcium zinc stabilizer and an organotin.
10. A method of preparing a body for a tracheostomy tube according to any one of claims 1 to 9, characterised in that it comprises the following steps:
s1, mixing the raw materials: after the raw materials are subjected to ultrasonic cleaning, mixing the components according to the corresponding weight to prepare a mixture;
s2, injection molding: and heating and melting the mixture, injecting the mixture into a mold, performing mold closing, air exhaust and pressure maintaining treatment, heating and sintering, cooling to room temperature, and taking out from the mold to obtain the tracheotomy tube body.
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| CN115025283A (en) * | 2022-06-14 | 2022-09-09 | 上海洲康医疗器械有限公司 | Thermo-sensitive fallopian tube and preparation method thereof |
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| CN108276698A (en) * | 2018-01-26 | 2018-07-13 | 福建宏翔塑胶有限公司 | A kind of battery protection stretched PTFE film and its manufacture craft |
| CN108912583A (en) * | 2018-07-18 | 2018-11-30 | 浙江威思康塑胶有限公司 | A kind of preparation method for the PVC cable material that low plasticiser processability is excellent |
| CN113336944A (en) * | 2021-06-11 | 2021-09-03 | 上海达华药业有限公司 | Silicon rubber and production process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115025283A (en) * | 2022-06-14 | 2022-09-09 | 上海洲康医疗器械有限公司 | Thermo-sensitive fallopian tube and preparation method thereof |
| CN115025283B (en) * | 2022-06-14 | 2023-08-08 | 上海洲康医疗器械有限公司 | Thermosensitive fallopian tube and preparation method thereof |
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