CN113332249A

CN113332249A - Lianhua antipyretic granules for resisting warm diseases

Info

Publication number: CN113332249A
Application number: CN202110860867.4A
Authority: CN
Inventors: 胡红进
Original assignee: Jinhua Polytechnic
Current assignee: Jinhua Polytechnic
Priority date: 2021-07-28
Filing date: 2021-07-28
Publication date: 2021-09-03

Abstract

The invention relates to the technical field of Chinese patent medicines, and discloses a honeysuckle antipyretic granule for resisting warm diseases, which comprises the following raw medicinal materials and auxiliary materials in parts by weight: 150 parts of ephedra, 150 parts of almond, 500 parts of gypsum, 150 parts of honeysuckle, 300 parts of weeping forsythia, 300 parts of isatis root, 150 parts of radix codonopsitis, 150 parts of astragalus, 150 parts of red peony root, 150 parts of cortex moutan, 150 parts of dried rehmannia root, 150 parts of rhizoma anemarrhenae, 150 parts of figwort, 150 parts of coptis, 150 parts of phellodendron, 150 parts of scutellaria, 150 parts of rhubarb, 120 parts of liquorice and 300 parts of mirabilite. The traditional Chinese medicine composition is prepared from 19 traditional Chinese medicines including ephedra, almond, gypsum, honeysuckle, fructus forsythiae, radix isatidis, codonopsis pilosula, astragalus membranaceus, radix paeoniae rubra, cortex moutan and the like, has the effects of clearing heat, reducing internal heat, resisting bacteria, diminishing inflammation and viruses, improving the immune function of animals, relieving constipation and promoting appetite of the animals, has a remarkable curative effect on hyperpyrexia or blue ear diseases of live pigs, can greatly reduce the death rate of the live pigs, and is low in production cost and simple to feed.

Description

Lianhua antipyretic granules for resisting warm diseases

Technical Field

The invention relates to the technical field of Chinese patent medicines, in particular to a honeysuckle antipyretic granule for resisting warm diseases.

Background

The epidemic disease prevention and control problem in modern pig raising production is that although various vaccines and chemicals exist, the reliability of vaccine protection is not high for porcine reproductive and respiratory syndrome, and attenuated vaccines have the possibility of returning to the ancestor and increasing the toxicity, most pig farms are not willing to use porcine reproductive and respiratory syndrome vaccines to prevent porcine reproductive and respiratory syndrome, and national laws and regulations prohibit the use of chemical drugs (antiviral western medicines), and the conventional treatment method (antibiotics such as compound aminopyrine, dexamethasone, VC and Toosendan sodium) is adopted for the porcine reproductive and respiratory syndrome (warm diseases), because the antibiotics have no treatment effect on viruses and only reduce the immune function of pigs, so that various mixed diseases such as other bacterial diseases, eperythrozoonosis and toxoplasmosis are easily induced, the prevention and control effect is very unsatisfactory, and the death rate is very high and can reach more than 70%.

The pig high fever or blue-ear disease (epidemic febrile disease) has the problems of strong infectivity, high morbidity and high mortality, generally adopts innocent treatment measures such as killing and disinfection and the like to cause negative influence on live pig protection, and at present, veterinary institutions lack sufficient control experience on the high fever or blue-ear disease (epidemic febrile disease), and the conventional treatment method has poor effect and high treatment cost and causes serious economic loss for the pig industry.

Disclosure of Invention

The invention aims to provide a honeysuckle antipyretic granule for resisting warm diseases, which aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

the anti-epidemic febrile disease honeysuckle antipyretic granules comprise raw medicinal materials and auxiliary materials, wherein the raw medicinal materials comprise the following components in parts by weight: 150 parts of ephedra, 150 parts of almond, 500 parts of gypsum, 150 parts of honeysuckle, 300 parts of weeping forsythia, 300 parts of isatis root, 150 parts of radix codonopsitis, 150 parts of astragalus, 150 parts of red peony root, 150 parts of cortex moutan, 150 parts of dried rehmannia root, 150 parts of rhizoma anemarrhenae, 150 parts of figwort, 150 parts of coptis, 150 parts of phellodendron, 150 parts of scutellaria, 150 parts of rhubarb, 120 parts of liquorice and 300 parts of mirabilite.

As a still further scheme of the invention: the auxiliary material consists of sucrose and dextrin, and the weight ratio of the sucrose to the dextrin is 2: 1.

As a still further scheme of the invention: the preparation process of the honeysuckle antipyretic granules comprises the following steps:

s1, screening and quality inspection of the raw medicinal materials: respectively taking 19 raw medicinal materials of ephedra, gypsum, almond, honeysuckle, forsythia, isatis root, codonopsis pilosula, astragalus, red paeony root, cortex moutan, dried rehmannia root, rhizoma anemarrhenae, figwort, coptis, phellodendron, radix scutellariae, rhubarb, liquorice and mirabilite, and selecting impurities of stones, mud blocks, rope ends, metallic chiffon, plastics, mildew and the like in the raw medicinal materials;

s2, crushing and soaking the raw medicinal materials; respectively crushing all 19 raw material medicines, and filtering the crushed raw material medicines through a 80-mesh sieve for later use; taking 150 parts of ephedra, 150 parts of almond, 150 parts of honeysuckle, 300 parts of fructus forsythiae, 300 parts of radix isatidis, 150 parts of codonopsis pilosula, 150 parts of astragalus membranaceus, 150 parts of red paeony root, 150 parts of cortex moutan, 150 parts of radix rehmanniae, 150 parts of rhizoma anemarrhenae, 150 parts of radix scrophulariae, 150 parts of coptis chinensis, 150 parts of golden cypress, 150 parts of scutellaria baicalensis, 150 parts of rheum officinale and 120 parts of liquorice out of the raw materials, and respectively placing the raw materials in a container and adding water until the raw materials are immersed for 1 hour;

s3, extracting and concentrating active ingredients: soaking 500 parts of the gypsum crushed and sieved in the step S2 in 8-10 times of water for 1 hour, placing the gypsum in a closed container pot, decocting the gypsum for 2 times with strong fire, respectively taking out the filtrates, mixing the filtrates, adding 500 parts of the mirabilite crushed and sieved, dissolving and filtering to obtain an extracting solution A, and cooling for later use; taking 150 parts of ephedra, 150 parts of almond, 150 parts of honeysuckle, 300 parts of fructus forsythiae, 300 parts of radix isatidis, 150 parts of codonopsis pilosula, 150 parts of astragalus membranaceus, 150 parts of red paeony root, 150 parts of cortex moutan, 150 parts of radix rehmanniae, 150 parts of rhizoma anemarrhenae, 150 parts of radix scrophulariae, 150 parts of coptis chinensis, 150 parts of golden cypress, 150 parts of scutellaria baicalensis, 150 parts of rheum officinale and 120 parts of liquorice soaked in the step S2, adding the extractive solution A, adding water with the mass being 12 times that of the extractive solution A, and placing the mixture in an extraction and concentration tank for treatment to obtain concentrated solution B;

s4, mixing the raw materials and the auxiliary materials in proportion: adding auxiliary materials of cane sugar and dextrin into the concentrated solution B in the step S3, and uniformly mixing, wherein the weight ratio of the concentrated solution B to the cane sugar to the dextrin is 2: 1: 0.5;

s5, wet granulation: putting the mixed material obtained in the step S3 into a wet mixing granulator for granulation to obtain fine and uniform granules;

s6, screening and quality inspection of the particulate matters: placing the particles obtained in the step S5 in a screening machine for screening, selecting the part for removing the agglomerates, smashing and screening, performing particle quality inspection on the screened particles, and selecting the part for removing the agglomerates and the fine powder;

s7, microwave sterilization and packaging of the particles: and (4) performing microwave sterilization on the granules obtained in the step S6, and subpackaging every 1000g to obtain the honeysuckle antipyretic granules.

As a still further scheme of the invention: the wet granulation process in the step S5 includes the following steps:

s51, putting the mixture into a material pot from a hopper above the wet mixing granulator, and closing the hopper;

s52, starting a stirring mechanism, enabling the mixed materials to rotate in the material pot under the stirring action of a stirring paddle in the stirring mechanism, and simultaneously rolling the mixed materials from outside to center along the direction of a conical wall to form a semi-flowing efficient mixing state, wherein the materials are collided and dispersed to achieve full mixing;

s53, adding an adhesive into the material pot, gradually wetting the powder material by injecting the adhesive, changing the material properties, enhancing the extrusion, friction and kneading of the materials by the stirring paddle and the conical wall, gradually generating a liquid bridge, gradually converting the materials into loose soft materials, cutting the soft materials into fine and uniform particles by the granulating knife in a semi-flowing state, and realizing the phase conversion of the materials;

s54, opening the discharge door, and pushing the wet particles out of the hopper under the centrifugal action of the stirring paddle.

As a still further scheme of the invention: the concentration treatment mode of the concentrated solution B in the step S3 is as follows: ultrasonic treatment is carried out for 1 hour at 60 ℃ and the relative density is 1.2-1.3 g/cm³。

As a still further scheme of the invention: the rotation speed of the stirring paddle in the step S52 is controlled at 160rpm, and the rotation speed of the granulating knife in the step S53 is controlled at 880 rpm, 1280 rpm.

Compared with the prior art, the invention has the beneficial effects that:

the traditional Chinese medicine composition is prepared from 19 traditional Chinese medicines including ephedra, almond, gypsum, honeysuckle, forsythia, isatis root, codonopsis pilosula, astragalus, red paeony root, cortex moutan, dried rehmannia root, rhizoma anemarrhenae, figwort root, coptis, phellodendron, scutellaria, rheum officinale, liquorice and mirabilite, has the effects of clearing heat, reducing pathogenic fire, resisting bacteria, diminishing inflammation, resisting viruses, improving the immune function of animals, relieving constipation and promoting the appetite of the animals, has a remarkable curative effect on high fever diseases or blue ear diseases of live pigs, can greatly reduce the death rate of the live pigs, and has the advantages of low production cost and simple medicine feeding.

Detailed Description

In the embodiment of the invention, the anti-epidemic febrile disease lianhua qingwen granules comprise the following raw medicinal materials and auxiliary materials in parts by weight: 150 parts of ephedra, 150 parts of almond, 500 parts of gypsum, 150 parts of honeysuckle, 300 parts of weeping forsythia, 300 parts of isatis root, 150 parts of radix codonopsitis, 150 parts of astragalus, 150 parts of red peony root, 150 parts of cortex moutan, 150 parts of dried rehmannia root, 150 parts of rhizoma anemarrhenae, 150 parts of figwort, 150 parts of coptis, 150 parts of phellodendron, 150 parts of scutellaria, 150 parts of rhubarb, 120 parts of liquorice and 300 parts of mirabilite.

Gypsum Fibrosum has effects of clearing heat and purging pathogenic fire, and can be used for treating excessive heat in qi system and cough due to lung heat;

rhizoma anemarrhenae has effects of clearing heat, nourishing yin, moistening lung, and promoting fluid production, and can be used for treating stomach heat, cough due to lung heat, internal heat due to yin deficiency, and constipation due to intestinal dryness;

the ephedra herb has the effects of relieving exterior syndrome and dispelling cold, and benefiting the lung and relieving asthma, has strong sweating effect, is a group medicine with pungent and warm sweating, is suitable for aversion to cold, fever and no sweat and the like caused by external wind-cold, can ventilate and smooth lung qi, has strong asthma relieving effect, and is used for treating cough and asthma caused by wind-cold feeling and obstruction of lung qi;

the figwort has the effects of nourishing yin to reduce pathogenic fire, cooling blood and detoxifying, can reduce pathogenic fire and nourish yin liquid, treats both principal and secondary aspects of diseases, and can be used for treating both toxic heat and excessive fire and internal heat due to yin deficiency;

cortex moutan has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and is suitable for heat toxin and macula caused by heat entering blood system;

the coptis chinensis has the effects of clearing heat, drying dampness, purging fire, removing toxin, clearing dryness, removing dampness, and treating gastrointestinal damp-heat stagnation, has an inhibiting effect on shigella, salmonella typhi, escherichia coli, staphylococcus, streptococcus hemolyticus, streptococcus pneumoniae, influenza virus, leptospira and the like, and can enhance the phagocytic capacity of leukocytes;

the scutellaria baicalensis has the effects of clearing heat, eliminating dampness, purging fire, removing toxicity and stopping bleeding, is mainly used for clearing and purging excessive heat in upper jiao, is particularly good for clearing lung heat, is used for treating lung wind heat affecting lung, is matched with the almond and the fructus forsythiae, has the effects of clearing heat, calming, reducing blood pressure, reducing permeability of capillary vessels and the like, and has the inhibiting effect on shigella, salmonella typhi, paratyphoid bacteria, escherichia coli, staphylococcus, influenza virus, streptococcus pneumoniae and the like;

phellodendron bark has the functions of clearing heat and drying dampness, purging fire and removing toxicity, and reducing deficiency heat, and is mainly used for reducing deficiency heat, and treating fire excess from yin deficiency. Has protective effect on blood platelet, and can promote absorption of subcutaneous hemorrhage;

fructus forsythiae has effects of clearing heat and detoxicating, subsiding swelling and resolving hard mass, can clear heat and detoxicating, has inhibitory effect on Shigella, Salmonella typhi, Paratyphoid bacteria, Escherichia coli, Staphylococcus aureus, influenza virus, Streptococcus pneumoniae, etc., has vitamin P to reduce vascular permeability and fragility, prevents blood seepage, and has remarkable antipyretic effect;

the isatis root has the functions of clearing away heat and toxic materials, cooling blood and relieving sore throat, is good at relieving excess heat and fire toxin, clearing heat and cooling blood, is used for treating wind-heat type cold or early stage of epidemic febrile disease, has the inhibiting effect on influenza viruses of gram-positive bacteria and gram-negative bacteria, can enhance the immunologic function, and has obvious antipyretic effect;

rhubarb has the effects of purging heat and promoting bowel movement, cooling blood and removing toxicity, breaking knots and removing blood stasis, is used for treating excess heat of stomach and intestine and dryness accumulation stagnation, is a bitter and cold purgation medicament, is used for heat accumulation constipation and enhancing gastrointestinal motility.

Natrii sulfas has effects of purging pathogenic fire, relaxing bowels, moistening dryness and softening hard masses, is the key herb of spleen syndrome of excess heat dryness syndrome, and is suitable for excess heat accumulation, feces dryness accumulation and abdominal fullness, and the herb is not easy to be absorbed in small intestine after oral administration to form hypertonic saline solution, so that the intestinal tract can retain a large amount of water, the intestinal content is increased, the intestinal mucosa is stimulated, and intestinal peristalsis is enhanced reflexively.

The honeysuckle has the effects of clearing heat, dissipating heat and dispelling wind, is mainly used for symptoms of red, heat, swelling and pain, and has an inhibiting effect on shigella, salmonella typhi, typhoid fever bacteria, escherichia coli, staphylococcus, anti-influenza virus, streptococcus pneumoniae and the like;

the liquorice has the effects of tonifying spleen and qi, dispelling phlegm and relieving cough, regulating the middle warmer and relieving urgency, detoxifying, relieving drug toxicity and toxicity, and harmonizing the drugs, is good for tonifying spleen and stomach and benefiting heart qi, and treating spleen and stomach weakness, lassitude and weakness, has the effects of sweet taste and relieving lung moistening, is used for treating cough and asthma, can clear heat and detoxify when being used for raw, is often matched with honeysuckle and forsythia, can moderate toxicity and toxicity of certain drugs, and has the effects of harmonizing the drugs.

Semen Armeniacae amarum has effects of relieving cough and asthma, loosening bowel to relieve constipation, and can be used for treating asthma due to lung heat

Radix Codonopsis has effects of invigorating spleen and replenishing qi, invigorating spleen and replenishing lung, and can be used for treating spleen and stomach weakness, tiredness and weakness, lung deficiency cough and asthma, body fluid consumption thirst, nerve excitation, organism resistance enhancing, blood sugar increasing, and blood coagulation promoting;

radix astragali has effects of invigorating qi, invigorating yang, invigorating qi, consolidating superficial resistance, astringing wound, and promoting granulation, and can be used for treating weakness of spleen and stomach, tiredness, weakness, and short breath, enhancing myocardial contraction, and tonifying heart. Enhancing immunity.

Radix rehmanniae has effects of nourishing yin, promoting fluid production, clearing heat, cooling blood, and can be used for treating excess heat syndrome of blood system, heat damaging yin, fluid deficiency constipation, promoting blood coagulation, stopping bleeding, tonifying heart, and dilating renal blood vessel;

radix Paeoniae Rubra has effects of clearing heat and cooling blood, promoting blood circulation and dispelling blood stasis, and can be used for treating heat entering nutrient blood, and warm toxic macula.

Preferably, the auxiliary materials consist of sucrose and dextrin, and the weight ratio of the sucrose to the dextrin is 2: 1.

Preferably, the preparation process of the honeysuckle antipyretic granules comprises the following steps:

Preferably, the wet granulation process in the step of S5 includes the following steps:

Preferably, the concentration treatment method of the concentrated solution B in the step S3 is: ultrasonic treatment is carried out for 1 hour at 60 ℃ and the relative density is 1.2-1.3 g/cm³The ultrasonic extraction method has very low extraction efficiency of the effective components of the mineral medicinal materials, and has very high extraction efficiency of the effective components of the plant medicinal materials.

Preferably, the rotation speed of the stirring paddle in the step S52 is controlled at 160rpm, and the rotation speed of the granulating knife in the step S53 is controlled at 880 rpm, 1280 rpm.

The stage of the febrile disease of high fever or blue-ear disease (febrile disease) is divided into prodromal stage, symptom evident stage, fever duration and septicemia stage, and its eight-class syndrome differentiation, wei-defensive-qi-ying-blood syndrome differentiation, zang-fu organ syndrome differentiation, main symptoms and main syndrome changes are shown in table 1 below;

TABLE 1 comparison of pathological changes in stages of hyperpyrexia or porcine reproductive and respiratory syndrome (epidemic febrile disease)

To better illustrate the technical effect of the present invention, it is illustrated by the following tests:

randomly selecting 600 live pigs suffering from high fever or blue ear disease (warm fever), dividing the pigs into six groups, wherein 100 pigs in each group are respectively a comparative example I, a comparative example II, an example I, an example II, an example III and an example IV,

in the first comparative example, the sick pig is treated by selecting compound aminopyrine, dexamethasone and antibiotics;

in the second comparative example, the diseased pig is treated by using the compound aminopyrine, dexamethasone and antibiotics in combination with 4 kg/ton of astragalus polysaccharide particles

In the first embodiment, 3 kg/ton of compound aminopyrine and honeysuckle flower heat clearing granules are selected to treat sick pigs;

in the second embodiment, 2 kilograms of lotus antipyretic granules are taken together with 200 kilograms of water to treat sick pigs;

in the third embodiment, 50 g/time of the honeysuckle flower heat-clearing granules are selected and used for treating sick pigs by matching with secondary drinking water in days such as oxytetracycline and electrolytic multi-vitamin;

in the fourth embodiment, 50 g of honeysuckle flower heat-clearing granules are taken twice per day and matched with Annona coffee intramuscular injection, (2 parts of glucose and 1 part of normal saline) and decaVC, decaATP and decacoenzyme A decaantibiotic are taken for intravenous injection to treat sick pigs;

the effects of the sick pigs in the defense phase, qi phase, nutrition phase and blood phase are respectively observed and recorded in the following table 2;

TABLE 2 comparison of curative and preventive effects in various stages of high fever or blue ear disease (warm fever)

From table 2, it can be analyzed that: compared with the second comparative example, the sick pig is treated by the compound aminopyrine, dexamethasone and antibiotics which are matched with 4 kg/ton of astragalus polysaccharide particles, and the results show that: all 200 pigs died, with a mortality rate of 100%, and none survived, and further it can be concluded that: the compound aminopyrine, dexamethasone, antibiotics and astragalus polysaccharide particles have no effect on the treatment of the warm diseases;

example two pairs of sick pigs were treated with the lianhuaqingwen granules alone, and the results showed that: 100 live pigs suffering from the warm diseases are completely cured and survive, and the cure rate is 100 percent; further, it can be found that: the honeysuckle flower heat-clearing granules have remarkable treatment effect on the warm diseases;

in the first embodiment, compound aminopyrine is selected to be matched with the honeysuckle flower temperature clearing granules, in the third embodiment, the honeysuckle flower temperature clearing granules are selected to be matched with oxytetracycline, electrolytic multivitamins and the like, and sick pigs are treated by drinking water twice every day; the results show that: 200 live pigs suffering from the warm diseases are completely cured and survive, and the cure rate is 100 percent; further, it can be found that: when the composition is matched with the honeysuckle flower heat clearing granule for treatment, the compound aminopyrine, the terramycin, the electrolytic multi-vitamin and the like do not generate any side effect;

in the fourth blood stage, the warm-keeping granules with honeysuckle are matched with Annona coffee intramuscular injection, (2 parts of glucose and 1 part of normal saline) and decaVC, decaATP, decacoenzyme A and decaantibiotic are selected to treat sick pigs in the serious illness stage of animal diseases, and the results show that: after 6 days, 36 pigs have improved symptoms, normal body temperature and normal eating, and 64 pigs die, with the cure rate of 36 percent and the death rate of 64 percent; further, it can be found that: the Annona coffee intramuscular injection (1 part of normal saline, 2 parts of glucose and 1 part of ten-normal saline) ten-VC, ten-ATP and ten-coenzyme A ten antibiotics have obvious effect on life support of animal organisms, and the drug effect of the honeysuckle flower heat clearing granules is greatly improved.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention are equivalent to or changed within the technical scope of the present invention.

Claims

1. The anti-epidemic febrile disease honeysuckle antipyretic granules comprise raw medicinal materials and auxiliary materials, and are characterized in that the raw medicinal materials comprise the following components in parts by weight: 150 parts of ephedra, 150 parts of almond, 500 parts of gypsum, 150 parts of honeysuckle, 300 parts of weeping forsythia, 300 parts of isatis root, 150 parts of radix codonopsitis, 150 parts of astragalus, 150 parts of red peony root, 150 parts of cortex moutan, 150 parts of dried rehmannia root, 150 parts of rhizoma anemarrhenae, 150 parts of figwort, 150 parts of coptis, 150 parts of phellodendron, 150 parts of scutellaria, 150 parts of rhubarb, 120 parts of liquorice and 300 parts of mirabilite.

2. The anti-epidemic heat disease and fire-connecting antipyretic granules as claimed in claim 1, wherein said adjuvant is composed of sucrose and dextrin, and the weight ratio of sucrose to dextrin is 2: 1.

3. The anti-epidemic heat disease lianhuaqingwen granules according to claim 1, wherein the preparation process comprises the following steps:

4. The anti-epidemic heat disease lianhuaqingwen granules of claim 3, wherein the wet granulation process in step S5 comprises the following steps:

5. A temperature resistant heat pipe according to claim 3The Lianhua scourge clearing granule for the diseases is characterized in that the concentration treatment mode of the concentrated solution B in the step S3 is as follows: ultrasonic treatment is carried out for 1 hour at 60 ℃ and the relative density is 1.2-1.3 g/cm³。

6. The anti-febrile disease and fire-linked antipyretic granules as claimed in claim 4, wherein the rotation speed of the stirring paddle in step S52 is controlled at 160rpm and the rotation speed of the granulating blade in step S53 is controlled at 880 rpm and 1280 rpm.