CN113332231A - Silica gel scar patch with adjustable viscosity and preparation method thereof - Google Patents
Silica gel scar patch with adjustable viscosity and preparation method thereof Download PDFInfo
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- CN113332231A CN113332231A CN202110655466.5A CN202110655466A CN113332231A CN 113332231 A CN113332231 A CN 113332231A CN 202110655466 A CN202110655466 A CN 202110655466A CN 113332231 A CN113332231 A CN 113332231A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The invention discloses a silica gel scar plaster with adjustable viscosity and a preparation method thereof, belonging to the technical field of medical cosmetology, and the preparation method of the silica gel scar plaster with adjustable viscosity comprises the following steps: step (1) preparation of semi-cured silicone gel; step (2) preparing a silica gel film with different viscosities on two side surfaces; and (3) preparing the silica gel scar plaster. In order to solve the technical problem that the viscosity difference of the inner surface and the outer surface of the silicone gel is difficult to coordinate in the prior art, the invention controls the viscosity of the scar plaster by regulating and controlling the micro-level and nano-level bulges on the surface of the scar plaster of the silicone gel, thereby achieving the purpose of controlling the viscosity difference of the inner surface and the outer surface of the silicone gel; the control method is that the micro-nano level structures on different surfaces of the template A and the template B are transferred to the inner surface and the outer surface of the silica gel; and no solution is involved in the transfer printing process and no residual glue is generated in the transfer printing process, so that the transfer printing method is simple and quick to operate and has high efficiency-cost ratio.
Description
Technical Field
The invention belongs to the technical field of medical cosmetology, and particularly relates to a silica gel scar patch with adjustable viscosity and a preparation method thereof.
Background
After a human body is injured by a wound, particularly in the self-repairing process after an operation, scar hyperplasia is likely to be formed, and the scar hyperplasia is often generated on the face, the neck, the limbs, the trunk and the like of a patient, so that the physiological function of the skin is influenced, the appearance of the patient is also influenced, and psychological shadow in the heart of the patient is seriously caused. Therefore, the need to adopt a scientific and effective method for treating and preventing scar hyperplasia attracts more and more attention. How to prevent and treat scar hyperplasia is always a hot point of research in the field of wound repair, but no effective method is available in the aspect of scar hyperplasia prevention and treatment at present. The prior direct method for treating scar hyperplasia adopts operation treatment, but has the problems of pain and easy recurrence in the operation process, and also adopts drug treatment, although the effect is good, the side effect is more. Therefore, the current clinical treatment method for scars is generally a combination of a plurality of treatment methods, such as a treatment method matched with silica gel after operation.
The main component of the silicone gel is polydimethylsiloxane, which has the characteristics of transparency, tastelessness, no odor, hydrophobicity, heat resistance, oxidation resistance and the like, is insoluble in water and common organic solvents, has good biocompatibility, and is nontoxic, harmless and nonirritating to skin. Generally, the silicone gel is applied to the surface of a wound to inhibit scar hyperplasia through functions of pressure, shrinkage and the like, so that the silicone gel needs to have excellent adhesion to the skin contact surface, but when the viscosity of the outer surface is high, the silicone gel is easy to adhere to clothes, adsorbs dust and affects the appearance. Although the viscosity can be changed by regulating and controlling components in the existing silicone gel preparation process, the overall viscosity is consistent, and the difference between the internal viscosity and the external viscosity is difficult to coordinate. The addition of a nonwoven fabric or a paper film can reduce the stickiness of the outer layer, but affects the air permeability.
Therefore, the invention provides the silica gel scar paste with adjustable viscosity and the preparation method thereof, which realize high viscosity of the inner surface and low viscosity of the outer surface of the silica gel scar paste.
Disclosure of Invention
The invention aims to provide a silica gel scar patch with adjustable viscosity and a preparation method thereof, and aims to solve the technical problem that the difference of the inner surface viscosity and the outer surface viscosity is difficult to coordinate in the prior art.
The purpose of the invention can be realized by the following technical scheme:
a preparation method of a silica gel scar paste with adjustable viscosity comprises the following steps:
step (1), preparation of semi-cured silicone gel: uniformly coating the silica gel on the template A, standing at the room temperature of 25 ℃ until bubbles are completely separated out, heating the template A to the semi-solidified state of the silica gel, stopping heating, and cooling to obtain semi-solidified silica gel;
step (2), preparing a silica gel film with different viscosities of two side surfaces: the template B brushed with the release agent is pressed on the semi-cured silicone gel in the step (1) in a positive pressure manner, after the template B and the template A are heated to be completely cured, the template B and the template A are removed, and then the inverse structure of the micro-nano array structure prepared on the template can be transferred to the colloidal film, so that silicone gel films with different viscosities on two side surfaces are obtained;
step (3), preparation of the silica gel scar plaster: and (3) cutting the silica gel films with different viscosities on the two side surfaces obtained in the step (2), pasting anti-sticking films on the two sides, and packaging to obtain the silica gel scar paste with adjustable viscosity.
Step (1), the silicone gel is composed of polymethylsiloxane and a curing agent, and the weight ratio of polymethylsiloxane: the ratio of the curing agent is 3:1-9: 1.
In step (1), the template a is an array structure for preparing a high-viscosity silica gel film, and is one of a nanowire, a nano-pillar, a nano-pore, a nano-pyramid, a nano-grid, and a nano-wall.
Further, the release agent in the step (2) is one of silica gel release agents MC-313K and M-10.
Further, the template B in the step (2) is an array structure for preparing the low-viscosity silicone gel film, and is one of micron regular pyramids, inverted pyramids and micron-level cones.
Further, the mold B brushed with the release agent in the step (2) is manufactured by the following method: dissolving the release agent in water to dilute to 0.1-1 wt%, spraying or brushing the solution on the surface of a mold B, and air drying, natural drying at room temperature, or heating to dry at 30-80 ℃.
Further, the heating temperature in the step (2) is the curing temperature of the silica gel, and the heating time is 50-60% of the complete curing time.
Further, the anti-sticking film in the step (3) is a PE film or a release paper coated with silicone oil.
Further, in the packaging process in the step (3), a layer of waterproof plastic film is required to cover the outer surface of the anti-sticking film.
Obviously, the silicone gel scar plaster with adjustable viscosity realizes the difference and adjustment of the viscosity of the inner surface and the outer surface by adjusting the micro-nano array structures on the template A and the template B, the side of the silicone gel contacting the template A is the inner surface, and the side of the silicone gel contacting the template B is the outer surface.
The invention has the beneficial effects that:
in order to solve the technical problem that the viscosity difference of the inner surface and the outer surface of the silicone gel is difficult to coordinate in the prior art, the invention controls the viscosity of the scar plaster by regulating and controlling the micro-level and nano-level bulges on the surface of the scar plaster of the silicone gel, thereby achieving the purpose of controlling the viscosity difference of the inner surface and the outer surface of the silicone gel; the control principle is that the micro-nano level structures on different surfaces of the template A and the template B are transferred to the inner surface and the outer surface of the silica gel; the method is simple, effective and easy to operate, and can carry out high-precision control on the viscosity of the inner surface and the viscosity of the outer surface of the silica gel scar plaster.
The silica gel scar paste with adjustable viscosity, which is obtained by the invention, has the following advantages:
1. the silica gel scar patch can be directly pasted on a scar, is simple and convenient to use, has high viscosity at the position where the inner surface is pasted on the skin, can be well pasted on the skin, is not easy to fall off, has low viscosity at the outer surface, prevents adhesion, is not bonded with clothes, does not adsorb dust, and is attractive;
2. the material of the silica gel scar plaster is transparent and hydrophobic, has no chemical addition or toxic and side effects, and has strong adjustability of elastic modulus and good viscoelasticity; the transfer process has no solution participation and no residual glue treatment process, the operation is simple and quick, and the high efficiency cost ratio is realized;
3. the silica gel scar plaster has an adhesive micro-nano array structure, does not damage the surfaces of the template A and the template B, has the advantages of self-cleaning and repeated use and the like correspondingly, and is very suitable for preparing medical beauty products such as scar plaster and the like.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic flow chart of a preparation method of a silica gel scar patch with adjustable viscosity;
FIG. 2 is a scanning electron microscope image of the micro-nano structure after transfer printing on the silicone gel film in example 4;
FIG. 3 is the tangential/normal adhesion force of the inner surface of the high viscosity silicone gel corresponding to the nano-scale convex structures and the outer surface of the low viscosity silicone gel corresponding to the micro-scale concave structures on the silicone gel in example 4;
fig. 4 is a scanning electron microscope picture of the micro-nano structure after the transfer printing on the silicone gel film in example 5.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
as shown in fig. 1, a preparation method of a silicone gel scar patch with adjustable viscosity comprises the following steps:
step (1), preparation of semi-cured silicone gel: uniformly coating the silica gel on the template A, standing at the room temperature of 25 ℃ until bubbles are completely separated out, heating the template A to the semi-solidified state of the silica gel, stopping heating, and cooling to obtain semi-solidified silica gel;
step (2), preparing a silica gel film with different viscosities of two side surfaces: the template B brushed with the release agent is pressed on the semi-cured silicone gel in the step (1) in a positive pressure manner, after the template B and the template A are heated to be completely cured, the template B and the template A are removed, and then the inverse structure of the micro-nano array structure prepared on the template can be transferred to the colloidal film, so that silicone gel films with different viscosities on two side surfaces are obtained;
step (3), preparation of the silica gel scar plaster: and (3) cutting the silica gel films with different viscosities on the two side surfaces obtained in the step (2), pasting anti-sticking films on the two sides, and packaging to obtain the silica gel scar paste with adjustable viscosity.
Example 2:
determination of the curing time and temperature of a fixed-proportion silicone gel:
uniformly coating the silicon gel uniformly mixed according to a certain proportion (polymethylsiloxane: curing agent is 3:1) on a common template, standing for 2 hours at the room temperature of 25 ℃, putting the common template on a heating plate after bubbles are separated out and uniformly distributed, heating at the temperature of 40 ℃, heating until the silicon gel is completely cured, and measuring the time for completely curing.
The measured results showed a curing time of 8 hours.
Example 3:
determination of the curing time and temperature of a fixed-proportion silicone gel:
uniformly coating the silicon gel uniformly mixed according to a certain proportion (polymethylsiloxane: curing agent is 9:1) on a common template, standing for 2 hours at the room temperature of 25 ℃, putting the common template on a heating plate after bubbles are separated out and uniformly distributed, heating at the temperature of 100 ℃, heating until the silicon gel is completely cured, and measuring the time for completely curing.
The measured result showed a curing time of 30mi n.
Example 4:
a silica gel scar patch with adjustable viscosity is prepared by the following steps:
uniformly coating silica gel on a template A (a nanowire cluster structure), standing for 2 hours at room temperature of 25 ℃, placing the template A on a heating plate after bubbles are separated out and uniformly distributed, and treating for 4 hours at the temperature of 40 ℃;
dissolving a release agent into water at a mass ratio of 0.5 wt%, spraying the release agent solution onto a template B (a positive pyramid micron structure), and heating the template B on the silica gel obtained in the step (1) at a positive pressure for 4 hours at 40 ℃; uncovering the colloid film, namely transferring the inverse structures of the micro-nano array structures prepared on the template A and the template B onto the colloid film to obtain a silica gel film with different viscosities on two side surfaces;
and (3) cutting the silicone gel film obtained in the step (2), pasting PE films on two sides, and packaging to obtain a scar paste finished product.
Example 5:
a silica gel scar patch with adjustable viscosity is prepared by the following steps:
uniformly coating the silica gel on a template A, standing for 2 hours at the room temperature of 25 ℃, placing the template A on a heating plate after bubbles are separated out and uniformly distributed, and treating for 10 minutes at the temperature of 100 ℃;
dissolving a release agent into water with the mass ratio of 3 wt%, then brushing the release agent on a template B (an inverted pyramid micron structure), putting the template B on a silica gel under positive pressure, and continuously heating the template B for 20 minutes at 100 ℃; removing the colloid film, namely transferring the inverse structure of the micro-nano array structure prepared on the template onto the colloid film to obtain a silica gel film with different viscosities on two side surfaces;
and (3) cutting the silicone gel film obtained in the step (2), pasting release paper films on two sides, and packaging to obtain a scar paste finished product.
Example 6:
silicone gel film micro morphology, and tangential and normal adhesion force testing:
cutting the silicone gel films with different viscosities on the two side surfaces obtained in examples 4-5 into samples, and scanning by using a scanning electron microscope to obtain scanning electron micrographs as shown in fig. 2 and 4;
the test specimen obtained in example 4 was subjected to both the tangential and normal adhesion tests using a viscosity tester, and the test results are shown in FIG. 3.
Fig. 2 is a scanning electron microscope picture of the micro-nano structure after transfer printing on the silicone gel film in example 4, wherein fig. 2(a) is an SEM image of a side surface of the silicone gel film in contact with the template a (the template a is a nanowire array structure), fig. 2(B) is an SEM image of a side surface of the silicone gel film in contact with the template B (the template B is a pyramid array structure with a randomly distributed surface), and it can be seen from fig. 2(a) that the side surface of the silicone gel film in contact with the template a shows a randomly distributed micro-nano convex hull structure; as can be seen from fig. 2(B), the side of the silicone gel film in contact with the template B shows a random micron inverted pyramid pit array structure, which illustrates that in example 4, the inverse structure of the micro-nano array structures on the template a and the template B is successfully transferred to the colloidal film.
Fig. 3 is a tangential/normal adhesion force of the inner surface of the high-viscosity silicone gel corresponding to the nano-scale convex structure on the silicone gel and the outer surface of the low-viscosity silicone gel corresponding to the micro-scale concave structure in example 4, and the tangential and normal adhesion forces shown in the curves illustrate that the tangential and normal adhesion forces of the silicone gel film obtained in example 4 decrease linearly from inside to outside, which illustrates that the preparation method of the silicone gel scar patch with adjustable viscosity provided by the present invention realizes the difference of the viscosities of the inner and outer surfaces of the silicone gel, and solves the technical problems mentioned in the above background.
Fig. 4 is a scanning electron microscope image of the micro-nano structure after the micro-nano structure is transferred to the silicone gel film in example 5, which is similar to fig. 2, and shows that the inverse structures of the micro-nano array structures on the template a and the template B are successfully transferred to the colloidal film in example 5.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.
Claims (5)
1. The preparation method of the silica gel scar plaster with adjustable viscosity is characterized by comprising the following steps:
step (1), preparation of semi-cured silicone gel: uniformly coating the silica gel on the template A, standing at the room temperature of 25 ℃ until bubbles are completely separated out, heating the template A at the temperature of 30-120 ℃ for 5-600min, stopping heating, and cooling to obtain semi-cured silica gel;
step (2), preparing a silica gel film with different viscosities of two side surfaces: the template B brushed with the release agent is subjected to positive pressure on the semi-cured silicon gel in the step (1), the template A and the template B are removed after the template B is heated to be completely cured, and silicon gel films with different viscosities on two side surfaces are obtained;
step (3), preparation of the silica gel scar plaster: and (3) cutting the silica gel films with different viscosities on the two side surfaces obtained in the step (2), pasting anti-sticking films on the two sides, and packaging to obtain the silica gel scar paste with adjustable viscosity.
2. The preparation method of the silica gel scar paste with adjustable viscosity as claimed in claim 1, wherein the array structure of the template a in the step (1) is one of a nanowire, a nanopillar, a nanopore, a nanopyramid, a nano grid and a nano wall.
3. The method for preparing the silica gel scar paste with adjustable viscosity as claimed in claim 1, wherein the template B in the step (2) is one of a micron positive pyramid, an inverted pyramid and a micron grade cone.
4. The method for preparing the silicone gel scar paste with adjustable viscosity as claimed in claim 1, wherein the heating temperature in the step (2) is the curing temperature of the silicone gel, and the heating time is 50-60% of the complete curing time.
5. The silicone gel scar patch prepared by the preparation method of the silicone gel scar patch with adjustable viscosity according to claim 1.
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| CN105287441A (en) * | 2015-11-17 | 2016-02-03 | 哈尔滨乾佰纳生物药业有限公司 | Silica gel scar treatment strip and preparation method thereof |
| CN105668510A (en) * | 2016-03-01 | 2016-06-15 | 南开大学 | Two-step impressing method for biological single cell detection application |
| CN109848019A (en) * | 2017-11-30 | 2019-06-07 | 山东朱氏药业集团有限公司 | A kind of Silica hydrogel coating process of scar plaster |
| CN109852333A (en) * | 2017-11-30 | 2019-06-07 | 山东朱氏药业集团有限公司 | A kind of Silica hydrogel preparation process of scar plaster |
| CN111481347A (en) * | 2020-04-09 | 2020-08-04 | 苏州汇涵医用科技发展有限公司 | Silica gel scar plaster and preparation method thereof |
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2021
- 2021-06-11 CN CN202110655466.5A patent/CN113332231A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101939393A (en) * | 2008-01-30 | 2011-01-05 | Lts勒曼治疗系统股份公司 | Micro- and/or nano-structured protective or process film |
| CN104045054A (en) * | 2014-05-14 | 2014-09-17 | 中国科学院合肥物质科学研究院 | Method for preparing high-adhesion micro-nano array structure film through wet etching and reverse transfer printing |
| CN104497905A (en) * | 2014-12-11 | 2015-04-08 | 安徽明讯新材料科技股份有限公司 | Low-viscosity protective film and preparation method thereof |
| CN105287441A (en) * | 2015-11-17 | 2016-02-03 | 哈尔滨乾佰纳生物药业有限公司 | Silica gel scar treatment strip and preparation method thereof |
| CN105668510A (en) * | 2016-03-01 | 2016-06-15 | 南开大学 | Two-step impressing method for biological single cell detection application |
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