CN113331323A - Pear and roxburgh rose composition and application thereof - Google Patents
Pear and roxburgh rose composition and application thereof Download PDFInfo
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- CN113331323A CN113331323A CN202110582293.9A CN202110582293A CN113331323A CN 113331323 A CN113331323 A CN 113331323A CN 202110582293 A CN202110582293 A CN 202110582293A CN 113331323 A CN113331323 A CN 113331323A
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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Abstract
The invention discloses a composition of pears and roxburgh roses and application thereof. The composition of the pear and the roxburgh rose comprises the following components in parts by weight: the composition comprises 1-10 parts of pears and 1-8 parts of roxburgh roses, wherein the pears and the roxburgh roses are combined for the first time, and the roxburgh roses are used as monarch drugs and are reinforced mutually, so that the composition has good effects on regulating emotion and improving intestinal health. The composition is prepared into products such as juice, tablets, powder, capsules and the like, and is matched with the appearance of a product with a healing effect, so that the anxiety of people is comprehensively relieved by accident in a light form of 'eating while playing', and the intestinal health is regulated. In addition, the invention also solves the problem of seasonal supply of the raw materials of the roxburgh rose, and powerfully promotes the development of the roxburgh rose industry.
Description
Technical Field
The invention particularly relates to a composition of pears and roxburgh roses and application thereof.
Background
Pear is a very familiar fruit, has various varieties, can be eaten raw or boiled together with rock candy and tremella, and is commonly used for relieving cough and moistening throat. Common consumers mostly know the pears, and even though the current deep-processed products taking the pears as main raw materials are discovered, the products have the effects of clearing away the lung-heat, moistening the lung, relieving cough and moistening the throat and the like no matter the beverages, paste formulations, tea bags and candies are adopted, the product homogenization is high, and the edible value of the pears is not fully developed.
The book Ben Cao Yan Yi (augmented materia Medica) says that: the 'pear, but sick wine polydipsia people, and food very good … …' polydipsia is a mental symptom, namely vexation accompanied by the feeling of wanting to drink water, and is mostly caused by mental factors, such as insomnia, anxiety, stuffiness and dislike emotional problems. The book materia medica Yuan (materia Medica) is characterized in that: pear, fructus Pyri, is indicated for internal heat accumulation. "national Chinese herbal compilation" states that: pear, fructus Pyri, has the actions of nourishing yin and clearing lung-heat, and is indicated for restlessness due to heart fire. "follow-rest diet book": pear, fructus Pyri, clears stomach, washes away heat and calms out wind, dissipates nodulation and unblocks intestines. Various ancient books refer to the functions of dispersing pathogen accumulation, relieving stagnated fire, treating heart fire and the like from different angles.
By using LC-MS (liquid chromatography-mass spectrometry)[1]、GC-MS[2]、UPLC–PDA–MS/MS–ESI[3]And (3) identifying flavonoid, phenols, saccharides and other components from the peel, pulp and core of the snow pear, the Dangshan pear and the autumn white pear respectively by using an analysis technology, wherein the content of the flavonoid and the phenols in the peel is the highest. According to research, the chemical components of the mild plant tranquilization traditional Chinese medicine mainly comprise polysaccharides, flavonoids, saponins, terpenes, anthraquinones, phenolic acids, alkaloids and the like[4]. Therefore, from the aspect of component analysis, the pear may have the functions of soothing the nerves and relieving depression, although no clear efficacy research result confirms the inference.
The physician considers that the depression syndrome is mainly caused by depression of mood, restlessness, fullness and oppression of chest, distending pain of hypochondrium, or irritability and crying, or foreign body sensation in pharynx, etc. Melancholia, anger, stagnation of liver-qi; worry about thinking and spleen failing to transport and transform; emotional hyperactivity and heart failure are the main causes and pathogenesis of depression.
According to the newly published global emotion report of 2019, "the world is funeral anytime than ever before", "people are more sad, angry and feared". The '2020 Chinese city female emotion report' shows: "97% of contemporary urban women consider that emotional freedom is more difficult than financial freedom, and about 1/5 women will smell the fragrance to regulate mood, thereby achieving" emotional freedom ". Then, what are the remaining 4/5 difficult to make mood free and not want to adjust mood by smelling the scent?
The traditional emotion regulating product is mainly aromatherapy, is limited by aromatherapy equipment and cannot be used anytime and anywhere. At present, no specific oral products for regulating emotion exist in China, and most of the oral products for promoting sleep are prepared from spina date seeds and lily serving as main raw materials. In recent two years, due to the big outbreak of the 'brain-intestine axis' view, new emotion regulating products which take probiotics as raw materials appear abroad. Accordingly, there is a need and an urgent need to provide consumers with mood modulating products in a wide variety of forms.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the composition of the pear and the roxburgh rose and the application thereof, and the composition makes up the relatively blank current situation of the existing emotion regulating oral product by scientifically matching the plant raw materials, can effectively relieve the anxiety emotion and regulate the intestinal health.
In order to achieve the above purpose, in a first aspect, the invention provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 1-10 parts of pear and 1-8 parts of roxburgh rose.
The pear has the functions of dissipating stagnation, relieving depression fire, treating heart fire and the like, contains flavonoid, phenols, saccharides and other components, but no clear effect research result proves that the pear has the effects of soothing nerves and relieving depression; the roxburgh rose is rich in potential nerve-soothing components such as quercetin, rutin, gallic acid and the like, and the roxburgh rose meets the characteristics of mild plant nerve-soothing Chinese herbal medicines in terms of medicine property although no research shows that the roxburgh rose has a mood regulating effect at present. In addition, the rosa roxburghii tratt dietary fiber content is high; pear can clear stomach and unblock intestine. The inventor finds that the composition takes the roxburgh rose and the pear as monarch drugs and mutually reinforced as the monarch drugs, has good effects of regulating emotion, relaxing bowel and improving intestinal health, and is natural, safe and good in taste; on the basis of the formula formed by the pears and the roxburgh roses, other raw materials with the functions of soothing the nerves, relieving depression and relaxing bowel can be added.
The variety of pear can be selected from white pear (Pyrus bretschneeri Rehd.) of Osmundae, sand pear (P.pyrifolia (Burm.f.) Nakai), and autumn pear (P.ussuriensis Maxim.) of Osmundae, but is not limited thereto.
In a second aspect, the present invention provides a Rosa roxburghii product made from the above composition. The fructus Rosae Normalis product can be food (including health food) or medicine.
Preferably, the Rosa roxburghii product is fruit juice, tablet, powder or capsule. The form of the Rosa roxburghii product is not limited thereto.
Preferably, the roxburgh rose product is packaged in a playful and interesting way. The roxburgh rose product is matched with a playful and interesting packaging form, so that on one hand, the roxburgh rose product is utilized to calm nerves and relieve depression, on the other hand, the achievement and pleasure of consumers are promoted by the timely feedback characteristic of food playing, and the negative emotion is eliminated.
In a third aspect, the present invention provides a method for preparing a rosa roxburghii tratt product, which comprises the following steps:
crushing pears, and concentrating the obtained pear juice to obtain concentrated pear juice; extracting dried fructus Rosae Normalis with water, and concentrating to obtain fructus Rosae Normalis concentrated juice; and mixing the concentrated pear juice with the concentrated roxburgh rose juice to obtain a roxburgh rose product, wherein the weight ratio of the pears to the dry roxburgh rose is as follows: 1-10: 1-3 of dry roxburgh rose;
or crushing the pears and the fresh roxburgh roses, and concentrating the obtained juice to obtain mixed concentrated juice of the pears and the roxburgh roses, so as to obtain the roxburgh rose product, wherein the weight ratio of the pears to the fresh roxburgh roses is as follows: fresh roxburgh rose is 1-10: 3-8.
The fresh roxburgh rose is difficult to store, needs to be processed on site after being harvested in 8-9 months in the mature season every year, has high production pressure, and is dried to prepare the dry roxburgh rose, so that the moisture is controlled below 5 percent, and the fresh roxburgh rose is convenient to store. In the research process, the main components of the dry roxburgh rose water extract and the mature fresh roxburgh rose water extract are basically the same (the contact ratio reaches 99 percent), and the oxidation resistance of the dry roxburgh rose water extract under the mass concentration of 0.0008 mg/mu L is similar to that of the fresh roxburgh rose raw juice with the equal mass concentration, which indicates that the components and the activity of the dry roxburgh rose are basically similar to those of the fresh roxburgh rose. In order to relieve the production pressure and furthest improve the feasibility of the industrialized application of the roxburgh rose, the invention respectively develops the roxburgh rose product taking the fresh roxburgh rose and the dry roxburgh rose as the raw materials and the preparation process thereof, relieves the production pressure and furthest improves the feasibility of the industrialized application of the roxburgh rose.
The preparation method respectively using fresh roxburgh rose and dry roxburgh rose as raw materials has the advantages that the prepared roxburgh rose product has good mood regulation and bowel relaxing effects, is good in taste and can be directly drunk, meanwhile, due to the fact that the roxburgh rose product is rich in vitamin C and other components, the oxidation of polyphenols can be delayed, and the color, the flavor and the nutritional components of the fruit juice can be effectively maintained without adding food additives. In addition, the preparation method respectively using the fresh roxburgh rose and the dry roxburgh rose as the raw materials enhances the functions of regulating mood and relaxing bowel by utilizing the synergistic effect of the roxburgh rose and the roxburgh rose, and compared with the fresh roxburgh rose raw juice, the fresh roxburgh rose raw juice and the dry roxburgh rose water extract with the same concentration of soluble solid matter, the obtained roxburgh rose product has better effects of regulating mood and relaxing bowel.
Preferably, the soluble solid content of the concentrated pear juice, the concentrated roxburgh rose juice and the mixed concentrated pear juice and roxburgh rose juice is more than 8 percent. More preferably, the soluble solid content of the concentrated pear juice, the concentrated roxburgh rose juice and the mixed concentrated pear and roxburgh rose juice is 8-12%.
Preferably, the juice from the crushing process is heat inactivated to prevent browning prior to concentration. The temperature of the heat-inactivating enzyme is usually selected to be 75-95 ℃ and the time is usually selected to be 5-7 s.
Preferably, the concentration temperature is controlled below 75 ℃. Low-temperature concentration is adopted to effectively protect the effective components.
Preferably, the water extraction temperature of the dry roxburgh rose is 40 ℃, the single water extraction time is 1h, the water extraction times are 2 times, and the material-liquid ratio is 1g:20 mL.
In a fourth aspect, the invention provides the use of the composition or the roxburgh rose product in mood regulation and/or bowel relaxing.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention combines the pears and the roxburgh roses for the first time, uses a simplified formula, selects natural and economic raw materials, and the obtained product has good taste, can effectively relieve the anxiety, regulate the intestinal health, makes up the current situation that the current oral product for regulating emotion is relatively blank, and provides a plurality of choices for consumers;
(2) the invention realizes the relaxed form of 'playing while eating' by adopting the appearance of the product with the healing effect, which unconsciously and comprehensively relieves the anxiety of people and simultaneously regulates the intestinal health;
(3) the invention not only provides a formula, a preparation and a preparation method thereof which take fresh roxburgh roses as raw materials, but also provides a formula, a preparation and a preparation method thereof which take dry roxburgh roses as raw materials, solves the problem of seasonal supply of roxburgh rose raw materials, and powerfully promotes the development of roxburgh rose industry.
Drawings
FIG. 1 is a chromatogram of the basic peaks of the aqueous extract of dried fructus Rosae Normalis and the aqueous solution of mature fresh fructus Rosae Normalis (m/z range: 50-1700).
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples. It will be understood by those skilled in the art that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In the examples, the experimental methods used were all conventional methods unless otherwise specified, and the materials, reagents and the like used were commercially available without otherwise specified.
Example 1
The embodiment provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 1 part of pear and 1 part of fresh roxburgh rose. Wherein, the pear and the fresh roxburgh rose are fresh, complete, without wormholes and without mildew.
The embodiment also provides a roxburgh rose product (hereinafter referred to as roxburgh rose product 1) prepared from the composition, and the preparation method of the roxburgh rose product comprises the following steps: washing equal weight of pears and fresh roxburgh roses (including washing processes such as flowing water conveying, soaking, brushing, high-pressure spraying and the like), crushing with skins and continuous kernels, taking juice for rough filtration, heating at 75-95 ℃ for 5-7 s to passivate enzyme activity and prevent browning, concentrating at 75 ℃ at low temperature until soluble solid is 10 +/-2%, and then aseptically filling to obtain concentrated fruit juice, namely the roxburgh rose product.
The roxburgh rose product is clear in color and can be directly drunk, the fresh and sweet taste of the roxburgh rose is matched with the faint scent and the sour taste of the roxburgh rose, so that the roxburgh rose product is excellent in taste and has good effects of regulating emotion and relaxing bowel, and meanwhile, the abundant vitamin C in the roxburgh rose can delay the oxidation of polyphenols, so that the color, the flavor and the nutritional ingredients of the juice can be effectively maintained without adding food additives. In addition, the concentrated fruit juice prepared by the embodiment can be used as a main raw material and processed into different dosage forms such as tablets, powder and capsules by adopting a conventional process, so that the diversified product requirements of consumers can be met. The anxiety can be comprehensively relieved by matching with different product formulations and carrying out 'food play' packaging design with the aim of relieving the anxiety.
Example 2
The embodiment provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 1 part of pear and 8 parts of fresh roxburgh rose. Wherein, the pear and the fresh roxburgh rose are fresh, complete, without wormholes and without mildew.
This example also provides a Rosa roxburghii product (hereinafter referred to as Rosa roxburghii product 2) made from the composition, and the preparation method of the Rosa roxburghii product is the same as that of example 1. The roxburgh rose product prepared by the embodiment is clear in color and can be directly drunk, the fresh and sweet taste of the roxburgh rose is matched with the faint scent and the sour taste of the roxburgh rose, so that the roxburgh rose product is excellent in taste and has good effects of regulating emotion and relaxing bowel, and meanwhile, the abundant vitamin C in the roxburgh rose can delay the oxidation of polyphenols, so that the color, the flavor and the nutritional ingredients of the juice can be effectively maintained without adding food additives. In addition, the concentrated fruit juice prepared by the embodiment can be used as a main raw material and processed into different dosage forms such as tablets, powder and capsules by adopting a conventional process, so that the diversified product requirements of consumers can be met. The anxiety can be comprehensively relieved by matching with different product formulations and carrying out 'food play' packaging design with the aim of relieving the anxiety.
Example 3
The embodiment provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 10 parts of pear and 3 parts of fresh roxburgh rose. Wherein, the pear and the fresh roxburgh rose are fresh, complete, without wormholes and without mildew.
This example also provides a Rosa roxburghii product (hereinafter, Rosa roxburghii product 3) made from the composition, and the preparation method of the Rosa roxburghii product is the same as that of example 1. The roxburgh rose product prepared by the embodiment is clear in color and can be directly drunk, the fresh and sweet taste of the roxburgh rose is matched with the faint scent and the sour taste of the roxburgh rose, so that the roxburgh rose product is excellent in taste and has good effects of regulating emotion and relaxing bowel, and meanwhile, the abundant vitamin C in the roxburgh rose can delay the oxidation of polyphenols, so that the color, the flavor and the nutritional ingredients of the juice can be effectively maintained without adding food additives. In addition, the concentrated fruit juice prepared by the embodiment can be used as a main raw material and processed into different dosage forms such as tablets, powder and capsules by adopting a conventional process, so that the diversified product requirements of consumers can be met. The anxiety can be comprehensively relieved by matching with different product formulations and carrying out 'food play' packaging design with the aim of relieving the anxiety.
Example 4
The embodiment provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 8 parts of pear and 1 part of dry roxburgh rose. Wherein, the pear is fresh, complete, without wormhole, without mildew.
The embodiment also provides a roxburgh rose product (hereinafter referred to as roxburgh rose product 4) prepared from the composition, and the preparation method of the roxburgh rose product comprises the following steps:
(1) selecting ripe dry roxburgh rose fruits, crushing, adding 20 times of drinking water by volume (namely the material-liquid ratio is 1g:20 mL) to extract twice at 40 ℃, extracting for 60min each time, combining filtrates to obtain roxburgh rose extract (namely the roxburgh rose dry fruit extract, the total number of organic compounds is 40; the total number of organic compounds of the roxburgh rose ripe fresh fruit extract prepared by the same process is 39, the liquid quality maps of the two extracts are shown in figure 1, the main components of the two extracts are basically the same, the contact ratio reaches 99%, the extracts both contain a large amount of vitamin C, flavonoids, amino acid components, a small amount of triterpenes and steroid aglycones), and concentrating at low temperature until the soluble solid content is 10 +/-2% to obtain roxburgh rose concentrated juice;
(2) washing pears (the weight of which is 8 times of the weight of the dried roxburgh rose fruits used in the step (1)) (including washing processes such as flowing water conveying, soaking, scrubbing, high-pressure spraying and the like), peeling, crushing with kernels, roughly filtering the juice, heating at 75-95 ℃ for 5-7 s to passivate the enzyme activity, preventing browning, and concentrating at low temperature until the soluble solid matter is 10 +/-2% to obtain concentrated pear juice;
(3) mixing all the concentrated juice of fructus Rosae Normalis with the concentrated juice of fructus Rosae Normalis, filtering with 400 mesh sieve, and aseptically packaging to obtain mixed concentrated juice, to obtain fructus Rosae Normalis product.
In addition, the roxburgh rose product prepared by the embodiment can also be used as a main raw material and processed into different dosage forms such as tablets, powder and capsules by adopting a conventional process, so that the diversified product requirements of consumers are met. The anxiety can be comprehensively relieved by matching with different product formulations and carrying out 'food play' packaging design with the aim of relieving the anxiety. The rosa roxburghii tratt product prepared by the embodiment has better functions of regulating emotion and relaxing bowel, and meanwhile, rich vitamin C in rosa roxburghii tratt can delay the oxidation of polyphenols, so that the color, the flavor and the nutritional ingredients of the juice can be effectively maintained without adding food additives.
Except for the raw materials of the roxburgh rose product 1 and the roxburgh rose product 4, the color, the fragrance and the taste of the roxburgh rose product 1 are different to a certain extent, the color of the roxburgh rose product 4 is darker, the fragrance of the roxburgh rose is stronger, the taste is slightly sour, the roxburgh rose product can be stored at normal temperature, the production cost is low, the roxburgh rose product 1 needs to be refrigerated, and the production and sale cost is high. Animal experiments prove that the two products have good functions of regulating emotion and relaxing bowel, the roxburgh rose product 1 is a high-end product, the roxburgh rose product 4 is an economic product, the product is suitable for consumers with higher requirements on taste, the two products can meet the requirements of different consumer groups, and the blank of the current emotion regulating oral product is filled.
Example 5
The embodiment provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 1 part of pear and 3 parts of dry roxburgh rose. Wherein, the pear is fresh, complete, without wormhole, without mildew.
This example also provides a Rosa roxburghii product (hereinafter, Rosa roxburghii product 5) made from the composition, and the preparation method of the Rosa roxburghii product is the same as that of example 4. The rosa roxburghii tratt product prepared by the embodiment has strong rosa roxburghii tratt fragrance and sour taste, can be directly drunk, can be stored at normal temperature, has low production cost, and has better functions of mood regulation and bowel relaxing, and meanwhile, the rosa roxburghii tratt is rich in abundant vitamin C which can delay the oxidation of polyphenols, so that the color, the flavor and the nutritional ingredients of the juice can be effectively maintained without adding food additives. In addition, the roxburgh rose product prepared by the embodiment can be used as a main raw material and processed into different dosage forms such as tablets, powder and capsules by adopting a conventional process, so that the diversified product requirements of consumers are met; meanwhile, different product formulations are matched, and the 'food play' packaging design is carried out with the aim of relieving the anxiety, so that the anxiety is comprehensively relieved.
Example 6
The embodiment provides a composition of pears and roxburgh roses, which comprises the following components in parts by weight: 10 parts of pear and 1 part of dry roxburgh rose. Wherein, the pear is fresh, complete, without wormhole, without mildew.
This example also provides a Rosa roxburghii product (hereinafter, Rosa roxburghii product 6) made from the composition, and the preparation method of the Rosa roxburghii product is the same as that of example 4. The rosa roxburghii tratt product prepared by the embodiment has strong rosa roxburghii tratt fragrance and sour taste, can be directly drunk, can be stored at normal temperature, has low production cost, and has better functions of mood regulation and bowel relaxing, and meanwhile, the rosa roxburghii tratt is rich in abundant vitamin C which can delay the oxidation of polyphenols, so that the color, the flavor and the nutritional ingredients of the juice can be effectively maintained without adding food additives. In addition, the roxburgh rose product prepared by the embodiment can be used as a main raw material and processed into different dosage forms such as tablets, powder and capsules by adopting a conventional process, so that the diversified product requirements of consumers are met; meanwhile, different product formulations are matched, and the 'food play' packaging design is carried out with the aim of relieving the anxiety, so that the anxiety is comprehensively relieved.
Examples of effects
The purpose is as follows: establishing a depression mouse model, and discussing whether the roxburgh rose products 1 and 4 have an improvement effect on symptoms of depression mice and unsmooth defecation caused by depression.
The method comprises the following steps: (1) the SPF grade C57BL/6 male mice are purchased, and are 7-8 weeks old, the weight of the male mice is about 17.6-20.8 g, and the animal qualification number is 1103242011015893. After quarantine, animals are randomly divided into 6 normal groups (namely negative control groups), 6 model groups (namely model control groups), 6A groups (containing fresh roxburgh roses), 6B groups (containing dried roxburgh roses) with low dose, 6B groups with medium dose and 6B groups with high dose. (2) Establishing a model: in the molding period, except the normal group, other animals establish depression animal models. Modeling was as follows: first day, combined stimulation of sound and light, 12h (day): using a JTC-1 type amazing and pain sensation experiment alternating current stimulator to stimulate voltage 53-63V, stimulating for 15s every 1h, and randomly setting the interval time of each electrical stimulation period; meanwhile, a CREE highlight zooming flashlight is used for 12h uninterrupted light stimulation; the noise stimulation was performed using UC4-75 ring, 12h without ring, and the noise intensity was measured with TES-1350A noise meter at 85-110 dB. Secondly, cold stimulation is carried out, the rat hair is properly wetted (the rat is prohibited to be thrown into water or the hair is completely wetted), and the rat hair is exposed to the environment at 4 ℃ for 2-4h (the maximum time can be prolonged if the rat state is good, the maximum time is 4h, and the minimum time is 2h if the rat state is not good). Thirdly, on the third day, the tail is suspended for 4h (13:00-17: 00). The tail suspension method comprises the following steps: the rat is placed in a suspension cage, the tail of the rat is suspended at the top of the cage, the forelimb is stepped at the bottom of the cage, and the hindlimb is suspended, so that the head of the rat is low. Fourthly, binding. Rats were loaded into a restraint device and placed horizontally for 4h (13:00-17: 00). Note: the four molding modes are carried out in a random cycle, the molding time can be unfixed, but the total molding time in one day is fixed. The animals in the molding group were placed in a mild stress environment for 6 weeks in total (a cycle was completed every four days). 2 weeks before molding, different test substances are administered to each group, specifically shown in table 1, the gavage is continued during molding, and the time and the frequency of administration of the test substances to each group are the same.
TABLE 1 dosage design and grouping
Detection indexes are as follows: the test was conducted in a sugar water-biased, open field test 6 weeks after the completion of molding, and the number and weight of the stools in 5 hours per mouse were recorded.
As a result: see table 2.
TABLE 2 test results
P <0.05, P <0.01 compared to model control.
Compared with the normal group, the sugar water preference rate of the animal sugar water preference test of the model control group is obviously reduced, the times of autonomous activities of the open field test are obviously reduced (P is less than 0.01), and the successful modeling of the depression mouse model is prompted. Compared with the model control group, the sugar water preference rate of the medium-high dose group in the group A and the group B is increased, the number of times of autonomous activities in the open field test is increased (P <0.05 or P < 0.01), and no statistical difference is found in the low dose group in the group B (P > 0.05). No statistical difference (P > 0.05) is found between the group A and the group B in the medium-high dose group, which indicates that the roxburgh rose product 1 and the roxburgh rose product 4 both have good emotion regulating effect. Compared with the normal group, the number of particles of the excrement and the weight of the excrement of the mice in the model control group are obviously reduced (P is less than 0.01), which indicates that the mice with depression have the problem of constipation and the constipation model is established. In the group A and the group B, compared with the model control group, the number of the grains of the excrement is obviously increased (P < 0.01) and the weight of the excrement is increased (P < 0.05). Compared with the model control group, the low-dose group in the group B has the advantages that the number of the excrement grains is increased (P is less than 0.05), and the weight of the excrement is increased (P is less than 0.05), so that the sample can obviously increase the number of the excrement grains and the weight of the excrement after being administered to the mice and has the function of promoting defecation. The low, medium and high dose groups in group A and composition B showed no statistical difference in stool grain number and stool weight (P > 0.05).
And (4) conclusion: under the test condition, the roxburgh rose and pear composition can obviously improve the symptoms of depression model mice and the problem of constipation caused by depression. In conclusion, the roxburgh rose and pear composition has the functions of regulating emotion and relaxing bowel.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Reference to the literature
[1] Chensiping, Zhanpan, liquid chromatography-mass spectrometry (LC-MS) was used to analyze the chemical composition [ J ] in snow pear, research and development of food 2015,36(24):146-148.
[2] The method comprises the steps of allergy relief, yellow wine, fragrance, beautiful plum, the silk of Tang silk and the following soldiers, and the metabolite spectrum [ J ] of the main quality characteristic components of Dangshan pear fruit is determined based on the GC-MS technology, the university of Anhui agriculture reports 2012,39(05): 692-.
[3] Lijing, Nioniaoyun, Caoyufen, Li Shixia, Yan Sha, Neong, Dangshan pear and autumn white pear phenolic substances UPLC-PDA-MS/MS-ESI analysis [ J ] Horticulture proceedings, 2016,43(04): 752) 762.
[4] Huangchuntao, Hou Xiaotao, Duzhengcai, Yangxue, Haibai, Deng Jia gang, the pharmacological action and chemical composition research progress of the peaceful plant tranquillizing Chinese medicine [ J/OL ]. world science and technology-Chinese medicine modernization 1-13[2021-02-04]. http:// kns.cnki.net/kcms/detail/11.5699.R.20210201.0914.002.html.
Claims (9)
1. The composition of the pears and the roxburgh roses is characterized by comprising the following components in parts by weight: 1-10 parts of pear and 1-8 parts of roxburgh rose.
2. A product of rosa roxburghii tratt, wherein the product is prepared from the composition of claim 1.
3. The Rosa roxburghii product of claim 2, wherein the Rosa roxburghii product is a juice, a tablet, a powder, or a capsule.
4. The Rosa roxburghii product of claim 2, wherein the Rosa roxburghii product is packaged in a play-enhancing and entertaining manner.
5. The preparation method of the roxburgh rose product is characterized by comprising the following steps of:
crushing pears, and concentrating the obtained pear juice to obtain concentrated pear juice; extracting dried fructus Rosae Normalis with water, and concentrating to obtain fructus Rosae Normalis concentrated juice; and mixing the concentrated pear juice with the concentrated roxburgh rose juice to obtain a roxburgh rose product, wherein the weight ratio of the pears to the dry roxburgh rose is as follows: 1-10: 1-3 of dry roxburgh rose;
or crushing the pears and the fresh roxburgh roses, and concentrating the obtained juice to obtain mixed concentrated juice of the pears and the roxburgh roses, so as to obtain the roxburgh rose product, wherein the weight ratio of the pears to the fresh roxburgh roses is as follows: fresh roxburgh rose is 1-10: 3-8.
6. The method according to claim 5, wherein the soluble solids content of each of the concentrated pear juice, the concentrated roxburgh rose juice and the concentrated mixed pear and roxburgh rose juice is 8% or more.
7. The method according to claim 5, wherein the juice obtained by the crushing treatment is heated to inactivate the enzyme activity to prevent browning before the juice is concentrated.
8. The method according to claim 5, wherein the concentration temperature is controlled to be 75 ℃ or lower.
9. Use of a composition according to claim 1 or a Rosa roxburghii product according to any of claims 2-4 for mood regulation and/or bowel relaxing.
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