CN113324946A - Multiple microbubble cavity coupling enhanced sensing technology - Google Patents
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- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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Abstract
A multiple microbubble lumen-coupled enhanced sensing technique comprising: 1, a broad-spectrum fiber laser, which is electrically excited, has low cost and easy integration and is used for generating broad-spectrum laser; 2, the optical fiber cone is formed by drawing glass fiber, is used for coupling the optical fiber laser to the micro-bubble cavity and is led into the spectral detector; 3, micro-bubble cavities are connected in series, the preparation of the micro-bubble cavities is realized by processing a hollow silicon dioxide capillary tube in the middle through high-power laser, and the micro-bubble cavities have high quality factors, are used for fluid to pass through and can imprison an optical field; 6, the spectrum analyzer can analyze the light intensity of different frequencies; 7 a processor technology based on a neural network deep learning algorithm.
Description
Technical Field
The invention relates to the field of optical microcavity waveguide coupling and microfluid detection, in particular to a multiple microbubble cavity coupling enhanced sensing technology and a microfluid detection method.
Background
Biological molecules in the microfluid, such as escherichia coli, bring great hidden danger to the health of people, so that the detection of the microorganisms such as the escherichia coli and the like is very important to the dietary safety. In practical application, the existing escherichia coli sensor is used for detecting by combining chemical reagents and other manual modes, and has the defects of low detection efficiency, inflexible detection, high labor cost and the like. The multiple microbubble cavity coupling enhanced sensing technology provided by the scheme can effectively detect the problems in the prior art, and can realize real-time, accurate, rapid and efficient detection of microorganisms such as escherichia coli.
Meanwhile, in order to solve the instability of single measurement of a single sensor, the technology provides a structure of connecting multiple micro-bubble cavities in series, so that the advantage of pollution-free testing of the micro-bubble cavities is utilized, the testing that biomolecules or other indexes in fluid can be subjected to interference-free multiple times and mutual reference processing can be carried out, and the sensing sensitivity and the multi-parameter simultaneous measurement capability of the system are greatly improved.
Disclosure of Invention
Technical problem to be solved
The present invention is directed to a multiple microbubble cavity coupling enhanced sensing technique to solve at least one of the above problems.
(II) technical scheme
In one aspect of the present invention, a multiple microbubble cavity coupling enhanced sensing technology is provided, including: fiber optic taper waveguide and microbubble cavity, wherein:
the optical waveguide is used for inputting a laser signal, coupling the laser into the micro-bubble cavity and then coupling the signal after the coupling sensing out of the micro-bubble cavity;
the multi-micro-cavity is connected in series, coupled with the optical waveguide, and can pass through a solution to be detected in a hollow capillary tube, and an optical signal coupled in and out of the optical waveguide and the micro-cavity coupling system is detected, so that the optical mode of the multi-micro-cavity can be changed by the external environment by utilizing the characteristic of high quality factors of the micro-cavity, and the detection of escherichia coli, typhoid bacillus and dysentery bacillus is realized.
In some embodiments of the invention, further comprising:
the optical fiber laser is used for emitting wide-spectrum laser and testing the optical mode of the micro-bubble cavity;
the grating spectrometer is used for performing spectral analysis on the optical signals coupled into and out of the micro-bubble cavity, so that the signals in the detection process are monitored in real time;
the neural network algorithm processor analyzes and processes signals monitored by the spectrometer in real time through a machine learning neural network algorithm, so that the microfluid detection is completed;
and the power supply control module is linked with the laser, the spectrometer and the neural network processor and is used for supplying power and controlling all modules of the detection system.
In some embodiments of the invention, further comprising:
and the packaging box is used for packaging the optical waveguide and the micro-bubble cavity so as to maintain the stability of the system.
In some embodiments of the present invention, the optical waveguide is an optical fiber taper, which couples the laser detection signal with the microcavity;
in some embodiments of the invention, the microcavity is a hollow submillimeter-based thin-walled capillary micro-bubble cavity, the radius of the microcavity is within the range of 10-100 μm, and a plurality of micro-bubble cavities are simultaneously prepared on one micro-flow channel, and the shapes of the micro-bubble cavities are kept different or almost consistent, so that targeted micro-flow test enhancement is completed, and self-reference or multi-parameter simultaneous test of a sensing system is realized.
In some embodiments of the present invention, the fiber laser is a broad spectrum laser, the frequency band is 1500nm-1600nm, and the output power is in the range of 1mw-15 mw;
in some embodiments of the present invention, the grating spectrometer has a working wavelength of 1500nm to 1600nm, can realize a spectral resolution of 0.02nm, and directly converts an input optical signal into an electrical signal of an optical spectrum;
in some embodiments of the present invention, the neural network algorithm processor may perform a machine learning pattern recognition algorithm on the input signal to complete the classification of the detection signal;
in some embodiments of the invention, the neural network algorithm processor can realize higher classification and discrimination precision of target signals through training of a large amount of initial experimental data at the early stage;
in another aspect of the present invention, a method for detecting microorganisms such as escherichia coli is also provided, which is applied to any one of the above sensors to detect and classify microorganisms in a fluid.
(III) advantageous effects
Compared with the prior art, the multiple microbubble cavity coupling enhanced sensing technology at least has the following advantages:
1. the method realizes real-time and rapid detection of microorganisms in the fluid by a neural network machine learning-based method, has high detection efficiency, is different from the detection realized by the traditional manual test paper, avoids uncertain factors caused by solution sampling and the like in the detection process, and realizes rapid and real-time detection;
2. the stability of the system can be well ensured by encapsulating the optical fiber vertebra and the micro-bubble cavity, so that the system can keep long-term stable performance, and better microbial detection capability is realized;
3. the system is based on the micro-bubble cavity and the neural network algorithm, and can further improve the system sensitivity and realize high-speed and accurate microorganism classification detection by optimizing the preparation process of the micro-bubble cavity and increasing the training data volume of the neural network algorithm.
Drawings
Fig. 1 is a diagram of a system and apparatus for multiple microbubble cavity coupled enhanced sensing technology according to an embodiment of the present invention.
[ description of symbols ]
1. Fiber laser 2, 4, 5 coupling optical fiber vertebra
3. Series micro-bubble cavity 6, grating spectrograph
7. Neural network processor 8, 9 grating spectrometer and processor
FIG. 2 is an apparatus diagram of a single embodiment of a multiple microbubble lumen coupled enhanced sensing technique according to an embodiment of the present invention.
[ description of symbols ]
1. Coupled optical fiber vertebra 2 series micro-bubble cavity
3. Packaging devices 4, 5, optical signal input/output port
6. 7, the solution flows into the outflow port.
Detailed Description
At present, the traditional escherichia coli detection technology based on an artificial detection mode has the defects of long detection period, low detection efficiency, high detection cost and the like, so that the real-time detection of the microbial environment in the solution is influenced. In view of this, the invention provides a multiple micro-bubble cavity coupling enhanced sensing technology, which realizes the detection of microbial escherichia coli through a micro-bubble cavity and the analysis and processing of detection data through a neural network algorithm, thereby improving the detection precision and detection efficiency and realizing the real-time monitoring of microbes in a fluid. In order to solve the instability of single measurement of a single sensor, the technology provides a structure of connecting multiple micro-bubble cavities in series, so that the advantage of pollution-free testing of the micro-bubble cavities is utilized, the test that biomolecules or other indexes in fluid can be subjected to interference-free multiple times but can be subjected to mutual reference processing is realized, and the sensing sensitivity and the multi-parameter simultaneous measurement capability of the system are greatly improved. Furthermore, the technology can improve the preparation process of the micro-bubble cavity by improving the algorithm, realize the detection and classification of more microorganisms and improve the real-time monitoring of the microbial environment in the fluid.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to specific embodiments and the accompanying drawings.
In one aspect of the embodiments of the present invention, a multiple microbubble cavity coupling enhanced sensing technology is provided, fig. 1 is a schematic structural diagram of an embodiment of the present invention, and as shown in fig. 1, the sensor includes: fiber vertebra, series micro bubble cavity and neural network algorithm processor.
In some embodiments of the invention, the optical fiber cone waveguide and the micro-bubble cavity are accurately controlled in coupling conditions through the nano translation stage to realize an optimal coupling state, and then the whole packaging is realized through means such as ultraviolet glue and the like, so that the micro-cavity coupling system with a high quality factor is completed. And then the packaged microcavity coupling system is integrally placed in a packaging cavity, so that the stability of the microcavity coupling system is ensured.
In some embodiments of the invention, the sensor further comprises a fiber laser, a grating spectrometer, and a neural network algorithm processor.
The fiber laser is a wide-spectrum light source, and the output of detection laser signals is realized, so that the detection of an optical mode in the detection process of the microcavity coupling system is realized. The grating spectrometer is a high-precision large-spectrum-width spectral signal analysis system, and realizes the conversion of a spectral signal into an electric signal by emitted broad-spectrum laser through the principle of grating diffraction, so that the real-time analysis of the spectral signal is realized, the spectrum of an optical signal coupled out of a micro-bubble cavity coupling system is detected, and the real-time change of an optical mode is analyzed. The neural network algorithm processor trains the neural network model by the premise of a large amount of marked data, so that the unknown real-time spectral signal data in the later period can be processed and analyzed based on the early training result, and the corresponding parameters of the substances in the fluid are judged from the real-time data analysis result.
A specific sensing method of the multiple microbubble cavity coupling enhanced sensing technology is shown in fig. 2. Referring to fig. 2, wherein 1, 2, and 3 correspond to the optical fiber vertebra, the micro-bubble cavity, and the encapsulation device, respectively, and correspond to the stable micro-bubble cavity coupling system. The 4, 5 ports correspond to input and output of optical signals, and the 6, 7 ports correspond to inflow and outflow ports of the solution to be measured. In the specific implementation process, the wide-spectrum light emitted by the optical fiber laser enters the optical fiber vertebra through the 4-port coupling by the optical fiber jumper wire and then is coupled with the micro-bubble cavity. Meanwhile, the solution to be detected introduced from the outside is also input into the capillary corresponding to the micro-bubble cavity through the 6 port and output from the 7 port, wherein in the micro-cavity coupling system consisting of the 1, 2 and 3 ports, the solution interacts with the optical signal coupled into the micro-bubble cavity by the optical fiber vertebra. When the concentration of substances in the solution or relevant parameters of the solution such as refractive index and the like change, the optical mode in the micro-bubble cavity changes, the optical mode is coupled into the optical fiber jumper wire through the optical fiber vertebra and then is output from the 5 ports, and the wide-spectrum laser signal carries a sensing signal generated by the influence of the solution.
The optical signal output from the 5 ports is detected by using a grating spectrometer, so that the real-time detection of the optical mode of the micro-bubble cavity coupling sensing system is realized, and the spectrum signal is converted into an electric signal. And finally, inputting the spectral signal data into a neural network algorithm processor to realize real-time detection and analysis of the optical mode in the micro-bubble cavity. Since the neural network algorithm has been trained through a large amount of labeled data, the corresponding content of microorganisms in the solution can be directly analyzed.
On the other hand, the embodiment of the invention also provides a multiple micro-bubble cavity coupling enhanced sensing technology which is applied to the sensor and used for detecting substances such as microorganisms in the solution.
In summary, the multiple micro-bubble cavity coupling enhanced sensing technology of the present invention realizes real-time detection of microbial particles in a solution through a micro-bubble cavity coupling system, and performs real-time analysis on an optical mode of the coupling system by combining a grating spectrometer and a neural network algorithm processor, thereby completing real-time detection of microbial molecules in the solution. Different from the existing manual detection mode, the automatic detection device has a more efficient and more accurate real-time detection function, and avoids the problems of misoperation, impurity introduction and the like caused by manual measurement.
Unless otherwise indicated, the numerical parameters set forth in the specification and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by the present invention. In particular, all numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term "about". Generally, the expression is meant to encompass variations of ± 10% in some embodiments, 5% in some embodiments, 1% in some embodiments, 0.5% in some embodiments by the specified amount.
Furthermore, "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.
The use of ordinal numbers such as "first," "second," "third," etc., in the specification and claims to modify a corresponding element does not by itself connote any ordinal number of the element or any ordering of one element from another or the order of manufacture, and the use of the ordinal numbers is only used to distinguish one element having a certain name from another element having a same name.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. A multiple microbubble cavity coupling enhanced sensing technology is characterized in that: the sensor comprises: fiber optic taper waveguide and concatenation microbubble chamber, wherein:
the optical fiber tapered waveguide is used for inputting laser signals, coupling the laser into the micro-bubble cavity and then coupling out the signals after coupling and sensing from the micro-bubble cavity;
the optical fiber coupling system comprises a serial micro-bubble cavity, an optical fiber cone, a micro-bubble cavity and a micro-bubble cavity coupling system, wherein the serial micro-bubble cavity is coupled with the optical waveguide and can pass through a solution to be detected in a hollow capillary tube, an optical signal coupled in and out of the optical waveguide and the micro-bubble cavity coupling system is detected, and the optical mode of the serial micro-bubble cavity can be changed by the external environment by utilizing the characteristic of high quality factors of the micro-bubble cavity.
2. The multiple microbubble lumen-coupled enhanced sensing technique of claim 1, wherein: further comprising:
the optical fiber laser is used for emitting wide-spectrum laser and testing the optical mode of the micro-bubble cavity;
the grating spectrometer is used for performing spectral analysis on the optical signals coupled into and out of the micro-bubble cavity, so that the signals in the detection process are monitored in real time;
the neural network algorithm processor analyzes and processes signals monitored by the spectrometer in real time through a machine learning neural network algorithm;
and the power supply control module is connected with the laser, the spectrometer and the neural network processor and is used for supplying power and controlling all modules of the detection system.
3. The multiple microbubble lumen-coupled enhanced sensing technique of claim 1, wherein: further comprising:
and the packaging box is used for packaging the optical waveguide and the micro-bubble cavity so as to maintain the stability of the system.
4. The multiple microbubble lumen-coupled enhanced sensing technique of claim 1, wherein: the optical waveguide is an optical fiber cone, and coupling of a laser detection signal and the microcavity is achieved.
5. The multiple microbubble lumen-coupled enhanced sensing technique of claim 1, wherein: the series micro-bubble cavity is a hollow thin-wall capillary micro-bubble cavity based on submillimeter, and the radius is within the range of 10-100 mu m; and a plurality of micro-bubble cavities are prepared on one micro-flow channel, and the micro-bubble cavities keep the shape difference or almost the same, so that the targeted micro-flow test enhancement is completed, and the self-reference or multi-parameter simultaneous test of the sensing system is realized.
6. The multiple microbubble lumen-coupled enhanced sensing technique of claim 2, wherein: the fiber laser is a wide-spectrum laser, the frequency range is 1500nm-1600nm, and the output power is 1mw-15 mw.
7. The multiple microbubble lumen-coupled enhanced sensing technique of claim 2, wherein: the working wavelength of the grating spectrometer is 1500nm-1600nm, the spectral resolution of 0.02nm can be realized, and the input optical signal is directly converted into an electrical signal of an optical spectrum.
8. The multiple microbubble lumen-coupled enhanced sensing technique of claim 1, wherein the neural network algorithm processor is capable of performing a machine-learned pattern recognition algorithm on the input signal to complete the classification of the probe signal.
9. Use of a multiple microbubble cavity coupled enhanced sensing technique as claimed in any one of claims 1 to 8 to achieve testing and classification of microfluidic characteristic parameters in a fluid.
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| US20100231903A1 (en) * | 2009-03-13 | 2010-09-16 | Mikhail Sumetsky | Microbubble optical resonator |
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| US20170307522A1 (en) * | 2014-10-09 | 2017-10-26 | Aston University | Optical detector module, measurement system and method of detecting presence of a substance in a test material |
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2021
- 2021-06-11 CN CN202110651050.6A patent/CN113324946A/en active Pending
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| US20100231903A1 (en) * | 2009-03-13 | 2010-09-16 | Mikhail Sumetsky | Microbubble optical resonator |
| CN102435348A (en) * | 2011-11-17 | 2012-05-02 | 中北大学 | High-Q optical microcavity-based temperature sensor and distributed type temperature sensing network |
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