CN113322159A - Fermentation cylinder for biological medicine - Google Patents
Fermentation cylinder for biological medicine Download PDFInfo
- Publication number
- CN113322159A CN113322159A CN202110610829.3A CN202110610829A CN113322159A CN 113322159 A CN113322159 A CN 113322159A CN 202110610829 A CN202110610829 A CN 202110610829A CN 113322159 A CN113322159 A CN 113322159A
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- China
- Prior art keywords
- pipe
- defoaming
- tank
- tank body
- base
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
Abstract
The invention discloses a fermentation tank for biological medicine, which comprises a base, a tank body, a tank cover, a defoaming device and a lifting device, wherein the base is arranged at the bottom of the tank body, a stirring motor and an air adding tank group are arranged in the base, a plurality of groups of staggered stirring paddles are arranged on a first rotating shaft of the stirring motor, an air adding pipe of each air adding tank in the air adding tank group extends to the outer side of the base, an exhaust pipe penetrates into the tank body, a water bath layer is arranged on the side wall of the tank body, a heating pipe is arranged in the water bath layer, the defoaming device is arranged on the lower surface of the tank cover, a lifting rope on the lifting device is tied on the tank cover, an exhaust pipe and a temperature sensor on the lower surface of the tank cover are arranged on the tank cover, and a liquid discharge pipe is arranged at the bottom of the tank body. The invention can uniformly dissolve oxygen in the fermentation liquor in the tank body, and can uniformly dissolve the oxygen in the fermentation liquor; utilize the foam breaker with the foam absorption, the broken bubble on fermentation broth surface, can carry out the defoaming without opening the jar body, the defoaming is fast.
Description
Technical Field
The invention relates to the technical field of fermentation tanks, in particular to a fermentation tank for biological medicines.
Background
The fermentation tank is a container which provides a good and satisfactory environment for the operation of a specific biochemical process, the fermentation is an important link in bioengineering, the fermentation equipment is important equipment of bioengineering corollary equipment, the fermentation equipment provides optimal growth and reproduction conditions for engineering bacteria or engineering cells, the optimal growth and reproduction conditions comprise external conditions such as temperature, pH value, stirring speed, dissolved oxygen content and the like, after the engineering bacteria or the engineering cells are grown and reproduced, various biochemical substances required by people are produced to the maximum extent in the form of inclusion bodies or supernatant, the fermentation tank is an external environment device which utilizes microorganisms to grow, reproduce and form products in the fermentation process, and the fermentation tank is widely applied to industries such as pharmaceutical chemical industry, bioengineering industry, brewing industry and the like.
The existing fermentation tank used for biological medicines has the following defects: 1. poor stirring effect and uneven stirring, which results in poor fermentation effect; 2. the dissolved oxygen is not thorough, so that the fermentation effect in the whole fermentation tube is not uniform and poor; 3. in the fermentation process, the amount of bubbles is large, and defoaming is not easy to happen, so that a large amount of foam is accumulated in the fermentation tube.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the invention aims to provide a fermentation tank for biological medicine, which solves the problems of poor fermentation effect, non-uniform dissolved oxygen, poor defoaming effect and the like.
The fermentation tank for the biological medicine comprises a base, a tank body, a tank cover, a defoaming device and a lifting device, wherein the base is arranged at the bottom of the tank body and is a box body, a stirring motor and an air charging tank group are arranged in the base, a first rotating shaft of the stirring motor penetrates through the bottom of the tank body and extends into the tank body, a plurality of groups of staggered stirring paddles are arranged on the first rotating shaft of the stirring motor, an air charging pipe of each air charging tank in the air charging tank group extends to the outer side of the base, an exhaust pipe penetrates into the tank body, a first electromagnetic valve and a second electromagnetic valve are respectively arranged on the air charging pipe and the exhaust pipe, a water bath layer is arranged on the side wall of the tank body, a heating pipe is arranged in the water bath layer, the lifting device is arranged at the top of the tank body through a limiting rod, two sides of the tank cover are sleeved on the limiting rod, the defoaming device is arranged on the lower surface of the tank cover, the lifting rope on the lifting device is tied on the irrigation cover, the irrigation cover is provided with an exhaust pipe and a temperature sensor on the lower surface of the tank cover, and the bottom of the tank body is provided with a liquid discharge pipe.
In some embodiments of the present invention, the defoaming device includes a mounting housing, and a defoaming pipe, a bubble collecting ring pipe, a liquid outlet pipe and a defoaming pump thereon, the defoaming pipe is arranged along a circumference of the bubble collecting ring pipe in a dispersed manner, a liquid inlet pipe of the defoaming pump is communicated with the bubble collecting ring pipe, the liquid outlet pipe is connected with a liquid outlet of the defoaming pump, the defoaming pipe is bent downwards and has an end part on the same horizontal plane, a plurality of fine defoaming holes are arranged on the downward bent part of the defoaming pipe, and the downward bent part of the defoaming pipe is divided into two circumferences.
In other embodiments of the present invention, the mounting case is mounted to the lower surface of the potting cover by a driving cylinder block, and a cylinder shaft of the driving cylinder block is fixed to the top of the mounting case.
In other embodiments of the present invention, the lifting device includes a mounting base and a lifting motor, the mounting base is fixed on the top of the limiting rod, the lifting motor is mounted on the mounting base, a reel is sleeved on a rotating shaft of the lifting motor, and a lifting rope on the reel penetrates through the mounting base.
In other embodiments of the present invention, a plurality of extension pipes are disposed at equal intervals on the exhaust pipe, a group of stirring paddles is disposed between two extension pipes, and a row of upward air outlets is disposed on the extension pipes.
In other embodiments of the present invention, the aperture of the air outlet is 0.3-0.5 mm.
In other embodiments of the present invention, a mechanical seal is sleeved on the first rotating shaft of the stirring motor at the bottom inside the tank body and at the top inside the base.
In other embodiments of the invention, the bottom in the tank body is an arc surface which is concave downwards and extends to a position close to the center, and the center position of the bottom in the tank body is an arc surface which is convex upwards.
According to the invention, the air-entrapping tank group is utilized to slowly release oxygen into the tank body, and the oxygen can be uniformly dissolved in the fermentation liquor in the tank body, so that the dissolving speed is high, and the oxygen can be uniformly dissolved in the fermentation liquor; the defoaming device is used for sucking away and breaking foam on the surface of the fermentation liquor, and then discharging the foam into the tank body, so that defoaming can be carried out without opening the tank body, and the defoaming speed and the defoaming effect are high; the fermentation temperature is stable, and the stirring effect is good.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic structural diagram of a fermentation tank for biomedical use according to the present invention.
Fig. 2 is a schematic structural view of an extension pipe according to the present invention.
Fig. 3 is a top view of the inside of the defoaming device according to the present invention.
Fig. 4 is an internal cross-sectional view of the defoaming apparatus according to the present invention.
Fig. 5 is a schematic structural view of the defoaming pipe provided by the present invention turning downward.
In the figure: 1. a base; 11. an air entrainment tank set; 111. an air adding pipe; 112. a first solenoid valve; 12. a stirring motor; 13. an exhaust pipe; 131. a second solenoid valve; 132. an extension pipe; 1321. an air outlet; 14. a first rotating shaft; 141. a mechanical seal; 15. a stirring paddle; 2. a liquid discharge pipe; 3. a water bath layer; 4. mounting a shell; 41. a defoaming pipe; 411. eliminating foam holes; 42. a liquid outlet pipe; 43. a poly bubble ring pipe; 44. a liquid inlet pipe; 45. a defoaming pump; 5. pouring a cover; 6. a mounting seat; 7. a lifting motor.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
The invention provides a fermentation tank for biological medicine, which comprises a base 1, a tank body, a tank cover 5, a defoaming device and a lifting device, wherein the base 1 is arranged at the bottom of the tank body, the base 1 is a box body, a stirring motor 12 and an air adding tank group 11 are arranged in the base 1, a first rotating shaft 14 of the stirring motor 12 penetrates through the bottom of the tank body and extends into the tank body, a plurality of staggered groups of stirring paddles 15 are arranged on the first rotating shaft 14 of the stirring motor 12, an air adding pipe 111 of each air adding tank in the air adding tank group 11 extends to the outer side of the base 1, an exhaust pipe 13 penetrates into the tank body, a first electromagnetic valve 112 and a second electromagnetic valve 131 are respectively arranged on the air adding pipe 111 and the exhaust pipe 13, a water bath layer 3 is arranged on the side wall of the tank body, a heating pipe 31 is arranged in the water bath layer 3, the lifting device is arranged at the top of the tank body through a limiting rod 61, two sides of the tank cover 5 are sleeved on the limiting rod 61, the defoaming device is arranged on the lower surface of the pouring cover 5, a lifting rope on the lifting device is tied on the pouring cover 5, an exhaust pipe 52 and a temperature sensor 51 on the lower surface of the tank cover 5 are arranged on the pouring cover 5, and a liquid discharge pipe 2 is arranged at the bottom of the tank body.
The pouring cover 5 is lifted by a lifting device, then fermentation liquor and strains are added into the tank body (before the fermentation temperature is approached by heating the water bath layer 3), then the pouring cover 5 is put down, and then the side edge of the pouring cover is fixed by a lock catch or a bolt and a nut. If a certain amount of oxygen in the fermentation liquor in the tank body needs to be regularly or periodically released, the oxygen can be slowly released into the tank body through the gas-adding tank group 11 through the gas exhaust pipe 13 to be dissolved in the fermentation liquor, and the liquid discharge pipe 2 is opened (the internal electromagnetic valve is opened), so that the purpose of effectively introducing the oxygen into the fermentation tank is achieved. And when the bubbles generated during fermentation are accumulated, the defoaming device can be eliminated in time. After fermentation, the fermentation liquor is discharged by using the liquid discharge pipe 2 (only by opening an electromagnetic valve on the liquid discharge pipe). When the temperature sensor 51 detects an abnormal temperature, the temperature is adjusted in time by the water bath layer 3.
The defoaming device comprises a mounting shell 4, and a defoaming pipe 41, a foam gathering ring pipe 43, a liquid outlet pipe 42 and a defoaming pump 45 which are arranged on the mounting shell, wherein the defoaming pipe 41 is dispersedly arranged along the circumference of the foam gathering ring pipe 43, a liquid inlet pipe 44 of the defoaming pump 45 is communicated with the foam gathering ring pipe 43, the liquid outlet pipe 42 is connected with a liquid outlet of the defoaming pump 45, the defoaming pipe 41 bends downwards, the end part of the defoaming pipe is on the same horizontal plane, a plurality of fine defoaming holes 411 are arranged on the downward bending part of the defoaming pipe 41, and the downward bending part of the defoaming pipe 41 is divided into two circumferences.
When the bubbles are accumulated on the surface of the fermentation liquid, the bubbles are accumulated around the defoaming pipe 41, and the defoaming pump 45 can perform periodic air suction to suck the bubbles from the defoaming pipe 41 into the foam collecting ring pipe 43, then the bubbles enter the defoaming pump 45 from the foam collecting ring pipe 43, and then the bubbles are discharged into the tank body from the liquid outlet pipe 42. Achieving the purpose of effective defoaming.
The mounting case 4 is mounted on the lower surface of the potting cover 5 by a driving cylinder block 43, and a cylinder shaft of the driving cylinder block 43 is fixed on the top of the mounting case 4.
The actuating cylinder 43 may push the mounting housing 4 up and down a distance to accommodate the level of broth surface in the tank to maximize the insertion of the bubble removal tube 41 into the foam.
The lifting device comprises a mounting seat 6 and a lifting motor 7, wherein the mounting seat 6 is fixed at the top of the limiting rod 61, the lifting motor 7 is installed on the mounting seat 6, a reel 71 is sleeved on a rotating shaft of the lifting motor 7, and a lifting rope on the reel 71 penetrates through the mounting seat 6.
The elevating motor 76 can raise or lower the cap 5, and it is more convenient to operate without manually picking up or lowering the cap 5.
The exhaust pipe 13 is provided with a plurality of extension pipes 132 at equal intervals, two of the extension pipes 132 are provided with a group of stirring paddles 15, and the extension pipes 132 are provided with a row of upward air outlets 1321.
The extension tube 132 increases the extent of gas entering the fermentation broth in the tank, increasing the rate at which oxygen is rapidly incorporated into the fermentation broth.
The aperture of the air outlet 1321 is 0.3-0.5 mm. The air outlet 1321 is small, so that oxygen can be slowly released, and the released oxygen can be timely dissolved in the fermentation liquor. The pressure of the charging tank is high, and the second electromagnetic valve 131 is opened to exhaust.
The first rotating shaft 14 of the stirring motor 12 is sleeved with a mechanical sealing element 141 at the bottom of the tank body and the top of the base 1. And the fermentation liquor is prevented from leaking at the first rotating shaft.
The tank body is characterized in that the bottom in the tank body is a downward-concave arc surface and extends to a position close to the center, and the center of the bottom in the tank body is an upward-convex arc surface. When the fermentation is discharged outside, the liquid is gathered at the bottom, and the upward convex arc surface prevents that after the liquid is patted, the liquid is gathered at the first rotating shaft 14 position at the center, so that the liquid exists for a long time and the rotating shaft can be corroded.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A fermentation cylinder for biological medicine which characterized in that: including base (1), the jar body, cover (5), fire fighting equipment and elevating gear, base (1) sets up in jar body bottom, base (1) is the box body, be equipped with agitator motor (12) and air entrainment jar group (11) in base (1), first pivot (14) of agitator motor (12) run through jar body bottom and extend to a jar internal portion, be equipped with crisscross multiunit stirring rake (15) on first pivot (14) of agitator motor (12), air entrainment pipe (111) of every air entrainment jar in jar group (11) extend to base (1) outside, blast pipe (13) run through jar internal, be equipped with first solenoid valve (112) and second solenoid valve (131) on air entrainment pipe (111) and blast pipe (13) respectively, be equipped with water bath layer (3) on the lateral wall of the jar body, be equipped with heating pipe (31) in water bath layer (3), the anti-foaming and anti-foaming tank is characterized in that the lifting device is installed at the top of the tank body through a limiting rod (61), two sides of the tank cover (5) are sleeved on the limiting rod (61), the defoaming device is installed on the lower surface of the tank cover (5), a lifting rope on the lifting device is tied on the tank cover (5), a temperature sensor (51) of an exhaust pipe (52) and the lower surface of the tank cover (5) is arranged on the tank cover (5), and a liquid discharge pipe (2) is arranged at the bottom of the tank body.
2. The fermenter according to claim 1, wherein: the defoaming device comprises a mounting shell (4), and a defoaming pipe (41), a foam gathering ring pipe (43), a liquid outlet pipe (42) and a defoaming pump (45) which are arranged on the mounting shell, wherein the defoaming pipe (41) is dispersedly arranged along the circumference of the foam gathering ring pipe (43), a liquid inlet pipe (44) of the defoaming pump (45) is communicated with the foam gathering ring pipe (43), the liquid outlet pipe (42) is connected with a liquid outlet of the defoaming pump (45), the defoaming pipe (41) is bent downwards, the end part of the defoaming pipe is positioned on the same horizontal plane, a plurality of fine defoaming holes (411) are arranged on the downward bent part of the defoaming pipe (41), and the downward bent part of the defoaming pipe (41) is divided into two circumferences.
3. The fermenter according to claim 2, wherein: the mounting shell (4) is mounted on the lower surface of the pouring cover (5) through a driving cylinder group (43), and a cylinder shaft of the driving cylinder group (43) is fixed to the top of the mounting shell (4).
4. The fermenter according to claim 1, wherein: the lifting device comprises a mounting seat (6) and a lifting motor (7), wherein the mounting seat (6) is fixed to the top of the limiting rod (61), the lifting motor (7) is installed on the mounting seat (6), a reel (71) is sleeved on a rotating shaft of the lifting motor (7), and a lifting rope on the reel (71) penetrates through the mounting seat (6).
5. The fermenter according to claim 1, wherein: the blast pipe (13) equidistant a plurality of extension pipes (132) of being equipped with, two be equipped with a set of stirring rake (15) between extension pipe (132), be equipped with a row of ascending venthole (1321) on extension pipe (132).
6. A fermenter for biomedical use according to claim 5, wherein: the aperture of the air outlet (1321) is 0.3-0.5 mm.
7. The fermenter according to claim 1, wherein: and a mechanical sealing element (141) is sleeved on the bottom of the stirring motor (12) in the tank body and the top of the stirring motor (12) in the base (1).
8. The fermenter according to claim 1, wherein: the tank body is characterized in that the bottom in the tank body is a downward-concave arc surface and extends to a position close to the center, and the center of the bottom in the tank body is an upward-convex arc surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110610829.3A CN113322159A (en) | 2021-06-01 | 2021-06-01 | Fermentation cylinder for biological medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110610829.3A CN113322159A (en) | 2021-06-01 | 2021-06-01 | Fermentation cylinder for biological medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113322159A true CN113322159A (en) | 2021-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110610829.3A Pending CN113322159A (en) | 2021-06-01 | 2021-06-01 | Fermentation cylinder for biological medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113322159A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113652326A (en) * | 2021-10-08 | 2021-11-16 | 广西壮族自治区农业科学院 | Fruit wine fermentation tank capable of adjusting temperature and air |
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| CN108949513A (en) * | 2018-07-25 | 2018-12-07 | 杭州宸祥环境工程有限公司 | A kind of microbial ferment device |
| CN208949266U (en) * | 2018-10-10 | 2019-06-07 | 天津市中科诺识生物科技有限公司 | High-efficient fermentation equipment convenient to overhaul |
| CN209555175U (en) * | 2019-02-18 | 2019-10-29 | 山东金酿生物科技有限公司 | A kind of brewers malt fermentation storage facilities |
| CN211111942U (en) * | 2019-07-17 | 2020-07-28 | 安徽赛德齐瑞生物科技有限公司 | Adjustable double-rod lifting cover fermentation tank |
| CN211339520U (en) * | 2019-11-19 | 2020-08-25 | 河南绿园药业有限公司 | Device for increasing dissolved oxygen of fermentation liquor |
| CN212914609U (en) * | 2020-04-22 | 2021-04-09 | 江西佳达实业有限公司 | Tea seed cake is equipped with immersion fluid device for pesticide |
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2021
- 2021-06-01 CN CN202110610829.3A patent/CN113322159A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203923202U (en) * | 2014-06-24 | 2014-11-05 | 温州市日中轻工机械有限公司 | Self-priming liquid fermentation fermentor |
| JP2017063616A (en) * | 2015-09-28 | 2017-04-06 | 積水化学工業株式会社 | Reaction vessel with antifoaming function |
| CN206266604U (en) * | 2016-07-02 | 2017-06-20 | 南昌绿捷日化有限公司 | Efficient froth breaking fermentation tank |
| CN205999383U (en) * | 2016-08-29 | 2017-03-08 | 津药瑞达（许昌)生物科技有限公司 | A kind of fermentation tank for amino acids production |
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| CN209555175U (en) * | 2019-02-18 | 2019-10-29 | 山东金酿生物科技有限公司 | A kind of brewers malt fermentation storage facilities |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113652326A (en) * | 2021-10-08 | 2021-11-16 | 广西壮族自治区农业科学院 | Fruit wine fermentation tank capable of adjusting temperature and air |
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Application publication date: 20210831 |
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