CN113318034A - Antioxidant composition, preparation method and application - Google Patents
Antioxidant composition, preparation method and application Download PDFInfo
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- CN113318034A CN113318034A CN202110720866.XA CN202110720866A CN113318034A CN 113318034 A CN113318034 A CN 113318034A CN 202110720866 A CN202110720866 A CN 202110720866A CN 113318034 A CN113318034 A CN 113318034A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention relates to the field of skin care products, and particularly discloses an antioxidant composition, a preparation method and application, wherein the antioxidant composition comprises the following components in percentage: siegesbeckia pubescens extract: 0.5-2 parts; the extract of the annona lancifolia fruits comprises the following components: 0.5-2 parts; auxiliary agent: 4.41-24.1; solvent: 74.9-91.59 parts. According to the invention, the phenolic oxygen free radicals are generated by the reaction of flavonoids in the siegesbeckia pubescens Makino extract and free radicals in a user body, the P pi conjugated structure is stable, so that the chain type chain reaction of the free radicals can be effectively inhibited, meanwhile, the adjacent hydroxyl or ketone groups on the flavonoids can chelate metal ions serving as catalysts of oxidation reaction in a human body, the oxidation reaction is effectively inhibited, and the flavonoids can reduce the antioxidant to play a role again, so that the oxidation resistance is enhanced, and the aging is effectively resisted. The active oxygen free radicals generated by cells can be removed through the rubus folius litchi fruit extract, and the oxidation resistance is effectively improved.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an antioxidant composition, a preparation method and application.
Background
In life, various factors of continuous contact between a human body and the outside, including respiration, external pollution, radiation irradiation and the like, continuously generate free radicals in the human body. Oxygen free radicals are active harmful substances released in the oxidation process in a human body, and randomly grab electrons of other molecules in the body to destroy the structures of cells, DNA, RNA and proteins, so that the functions of cell tissues and organs in the body are reduced, the function of an immune system in the body is reduced, and various diseases are caused and even die. Recent studies have been increasingly conducted to show that anti-oxidation is an important means for preventing aging because excessive free radicals produced by the human body decompose cells and tissues, thereby affecting the normal metabolic functions of the human body and causing various health problems.
At present, antioxidant skin care products for solving the problems appear on the market, but most of common antioxidant skin care products contain chemical components, and the safety and the effect of the components are always concerned, so that the problem to be solved is urgently needed to develop a mild and effective antioxidant skin care product.
Disclosure of Invention
The invention aims to provide an antioxidant composition, a preparation method and application thereof, and aims to solve the problems of poor safety and poor antioxidant effect of antioxidant skin care products in the current market.
In order to achieve the purpose, the invention adopts the following technical scheme:
the first purpose of the invention is to provide an antioxidant composition, which comprises the following components in parts by weight:
siegesbeckia pubescens extract: 0.5-2 parts;
the extract of the annona lancifolia fruits comprises the following components: 0.5-2 parts;
auxiliary agent: 4.41-24.1;
solvent: 74.9-91.59 parts.
Further, the antioxidant composition comprises, in percent:
siegesbeckia pubescens extract: 1.25 parts;
the extract of the annona lancifolia fruits comprises the following components: 1.25 parts;
auxiliary agent: 13.95 parts;
solvent: 83.55 parts.
Further, the auxiliary agent comprises at least one of a humectant, a stabilizer, a thickener, a preservative, a soothing agent and a penetration enhancer.
Further, the humectant comprises at least one of panthenol, 1, 3-butylene glycol, and glycerin.
Further, the stabilizer comprises EDTA-disodium.
Further, the thickener includes at least one of xanthan gum and sodium polyacrylate.
Further, the preservative comprises at least one of chlorphenesin, methyl ester and hexylene glycol.
Further, the comfort agent comprises allantoin.
A second object of the present invention is to provide a method for preparing the antioxidant composition as described above, comprising the steps of:
s1: uniformly mixing the auxiliary components, heating to 80-85 ℃, homogenizing, and keeping the temperature for 20min to obtain an auxiliary mixed solution;
s2: cooling the adjuvant mixture to below 45 deg.C, and adding Siegesbeckiae herba extract and Lycopersicon esculentum fruit extract to obtain antioxidant composition.
The third purpose of the invention is to provide the application of the antioxidant composition in skin care products, wherein the skin care products comprise water-type skin care products, gel-type skin care products, emulsion-type skin care products or cream-type skin care products.
The invention has the beneficial effects that:
the antioxidant composition provided by the invention comprises the following components in parts by weight: siegesbeckia pubescens extract: 0.5-2 parts; the extract of the annona lancifolia fruits comprises the following components: 0.5-2 parts; auxiliary agent: 4.41-24.1; solvent: 74.9-91.59 parts. According to the invention, the siegesbeckia pubescens Makino extract and the lycopus sieboldii fruit extract are added into the antioxidant composition, flavonoid contained in the siegesbeckia pubescens Makino extract reacts with free radicals in a user body to generate a phenolic oxygen free radical, the P pi conjugated structure is stable, so that the chain type chain reaction of the free radicals can be effectively inhibited, meanwhile, adjacent hydroxyl or ketone groups on the flavonoid can chelate metal ions serving as catalysts of oxidation reaction in a human body, the oxidation reaction is effectively inhibited from proceeding, and the flavonoid contained in the siegesbeckia pubescens Makino extract can also reduce other antioxidants (such as vitamins) to play a role again, so that the antioxidant capacity is enhanced, and the aging is effectively resisted. The active oxygen free radicals generated by cells can be obviously eliminated through the rubus folius fruit extract, and the oxidation resistance is effectively improved.
Detailed Description
The invention provides an antioxidant composition, a preparation method and application. In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete. The various starting materials used in the examples are, unless otherwise indicated, conventional commercial products.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The numerical values set forth in the examples of the present invention are approximations, not necessarily values. All values within the error range may be included without limiting to the specific values disclosed in the embodiments of the present invention, where the error or experimental conditions allow.
The numerical ranges disclosed in the examples of the present invention are intended to indicate the relative amounts of the components in the mixture and the ranges of temperatures or other parameters recited in the other method examples.
The invention provides an antioxidant composition, which comprises the following components in parts by weight:
siegesbeckia pubescens extract: 0.5-2 parts;
the extract of the annona lancifolia fruits comprises the following components: 0.5-2 parts;
auxiliary agent: 4.41-24.1;
solvent: 74.9-91.59 parts.
Further, the antioxidant composition comprises, in percent:
siegesbeckia pubescens extract: 1.25 parts;
the extract of the annona lancifolia fruits comprises the following components: 1.25 parts;
auxiliary agent: 13.95 parts;
solvent: 83.55 parts.
In this embodiment, the antioxidant composition can be applied to various skin care products, so that the skin care products containing the antioxidant composition provided by the invention have antioxidant capacity and effectively resist aging. Meanwhile, the antioxidant composition provided by the invention adopts natural components such as siegesbeckia pubescens Makino extract and annona chaeta fruit extract as main components, has low side effect on human bodies and even no side effect, can be suitable for various crowds, and the natural components contained in the antioxidant composition respectively have the effect of improving skin problems.
The antioxidant composition provided by the invention specifically comprises a siegesbeckia pubescens Makino extract and a lycopus sieboldii fruit extract.
Wherein the antioxidant composition specifically comprises herba Siegesbeckiae extract containing terpenoids, phenols, flavonoids, etc. The antioxidant action mechanism is realized by the following ways:
1. flavonoid contained in the siegesbeckia pubescens Makino extract can become a trap of free radicals, and reacts with free radicals in vivo to generate phenoxy free radicals, and the P conjugated structure is stable, so that chain reaction of the free radicals can be effectively inhibited;
2. the metal ions in the human body are generally catalysts for oxidation reaction, and the adjacent hydroxyl or ketone groups on the flavonoid can chelate the metal ions, so that the oxidation reaction is effectively inhibited;
3. the flavonoids contained in the siegesbeckia pubescens extract can also reduce other antioxidants (such as vitamins) to exert the effects again, thereby enhancing the antioxidant capacity and effectively resisting aging.
The siegesbeckia pubescens extract is prepared by the following method:
cleaning siegesbeckia Makino with water, air drying, cutting, sorting, and oven drying;
crushing the dried siegesbeckia Pubescens Makino into coarse powder, mixing the siegesbeckia Pubescens Makino powder with 70% ethanol to obtain a mixed solution, adding the mixed solution into an extraction tank, and soaking for 20-24 hours;
heating the mixed solution by an electric heating sleeve until the mixed solution is boiled at the temperature of 250-275 ℃ with big fire, cooling to the temperature of 120-130 ℃ and keeping the temperature for 2-3 hours;
cooling the extraction solvent to 70-80 deg.C, and filtering to obtain extractive solution;
repeating the heating reflux process for 3 times, mixing the extractive solutions obtained by 3 times, and concentrating the mixed extractive solution under reduced pressure until there is no alcoholic smell to obtain Siegesbeckiae herba extract.
The antioxidant composition specifically comprises a lycopus hirsutus fruit extract containing various phenolic substances, such as ferulic acid, rutin, gallic acid, catechin, caffeic acid, etc., wherein the various phenolic substances have synergistic effect to effectively improve antioxidant capacity. Oxygen molecules are reduced in a single electron form in cellular metabolism, and O ions generated by the oxygen molecules in the single electron reduction are further generated in vivo to generate H2O2And OH free radical with great toxicity, thus affecting the skin tenderness and smoothness, even accelerating the skin aging degree, and the addition of the Annona villosa fruit extract in the product can obviously eliminate active oxygen free radical generated by cells, has the elimination rate of 78.1 percent on Oi, is far greater than that of vitamin E (12.7 percent), and has the elimination effect on OH which is also greater than that of vitamin E.
The preparation method of the extract of the fruit of the annona lancifolia is the same as that of the extract of the siegesbeckia pubescens Makino.
Further, the antioxidant composition may further comprise an auxiliary agent to improve the performance of the antioxidant composition or to impart some performance to the antioxidant composition, the auxiliary agent comprising at least one of a humectant, a stabilizer, a thickener, a preservative, a soothing agent, and a penetration enhancer.
Specifically, the humectant is at least one of panthenol, 1, 3-butanediol, and glycerol; the stabilizer is EDTA-disodium; the thickener is at least one of xanthan gum and sodium polyacrylate; the preservative is at least one of chlorphenesin, methyl ester and hexanediol; the comfort agent is allantoin; the penetration enhancer is isosorbide dimethyl ether.
Further, the antioxidant composition also comprises an auxiliary agent, and specifically, the solvent is water.
In conclusion, the antioxidant composition provided by the invention has antioxidant capacity, can effectively resist aging, and can be widely applied to various skin care products.
In another aspect, the present invention provides a method for preparing the antioxidant composition, wherein the method comprises the following steps:
s1: uniformly mixing the auxiliary components, heating to 80-85 ℃, homogenizing, and keeping the temperature for 20min to obtain an auxiliary mixed solution;
s2: cooling the adjuvant mixture to below 45 deg.C, and adding Siegesbeckiae herba extract and Lycopersicon esculentum fruit extract to obtain antioxidant composition.
According to the invention, the siegesbeckia pubescens Makino extract and the lycopus sieboldii fruit extract are added into the antioxidant composition, flavonoid contained in the siegesbeckia pubescens Makino extract reacts with free radicals in a user body to generate a phenolic oxygen free radical, the P pi conjugated structure is stable, so that the chain type chain reaction of the free radicals can be effectively inhibited, meanwhile, adjacent hydroxyl or ketone groups on the flavonoid can chelate metal ions serving as catalysts of oxidation reaction in a human body, the oxidation reaction is effectively inhibited from proceeding, and the flavonoid contained in the siegesbeckia pubescens Makino extract can also reduce other antioxidants (such as vitamins) to play a role again, so that the antioxidant capacity is enhanced, and the aging is effectively resisted. The active oxygen free radicals generated by cells can be obviously eliminated through the rubus folius fruit extract, and the oxidation resistance is effectively improved.
In another aspect, the invention provides the use of an antioxidant composition in a skin care product, including an aqueous skin care product, a gel skin care product, an emulsion skin care product, or a cream skin care product.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The invention will be further described with reference to specific embodiments:
an antioxidant composition comprises the following effective components in parts by weight as shown in table 1:
TABLE 1 ingredients and proportions of antioxidant compositions
Wherein the siegesbeckia pubescens Makino extract is prepared by the following method:
cleaning siegesbeckia pubescens with water and air drying, cutting the dried siegesbeckia pubescens, sorting and drying. Pulverizing dried siegesbeckia Pubescens Makino into coarse powder, mixing siegesbeckia Pubescens Makino powder with 70% ethanol to obtain a mixed solution, adding into an extraction tank, and soaking for 20-24 hr; heating the mixed solution by an electric heating sleeve until the mixed solution is boiled at the temperature of 250-275 ℃ with big fire, cooling to the temperature of 120-130 ℃ and keeping the temperature for 2-3 hours; cooling the extraction solvent to 70-80 deg.C, and filtering to obtain extractive solution. Repeating the heating reflux process for 3 times, mixing the extractive solutions obtained by 3 times, and concentrating the mixed extractive solution under reduced pressure until there is no alcoholic smell to obtain Siegesbeckiae herba extract.
Wherein the preparation method of the extract of the fruit of the Maoyanlitchi is the same as that of the extract of the siegesbeckia pubescens Makino.
A method of preparing an antioxidant composition comprising:
s1: mixing the components (panthenol, EDTA-disodium, xanthan gum, sodium polyacrylate, chlorphenesin, methyl ester, hexanediol, glycerol, and allantoin) in the adjuvant, heating to 80-85 deg.C, homogenizing, and keeping the temperature for 20 min;
s2: cooling the adjuvant to below 45 deg.C, adding herba Siegesbeckiae extract, fructus litchi extract, 1, 3-butanediol and dimethyl isosorbide to obtain antioxidant composition.
Embodiments of the present invention will be described in detail with reference to examples 1 to 3 and comparative examples 1 to 3, and the components and the amounts in parts by weight thereof are shown in Table 2. It will be understood by those skilled in the art that the following examples are illustrative of the present invention only and should not be taken as limiting the scope of the invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
TABLE 2 ingredients and ratios of antioxidant compositions of examples 1-3 and comparative examples 1-3
The preparation methods of the examples and comparative examples are the same as those of the specific embodiment.
Detection example 1:
the antioxidant compositions prepared in examples 1 to 3 were subjected to physicochemical index tests in accordance with QB/T2660-2004. The results are as follows:
(1) appearance: colorless or pale yellow liquid.
(2) Color: colorless or yellowish.
(3) Odor: a slight characteristic odor.
(4) pH value: 4.0-8.5.
(5) And (3) inspecting the heat resistance stability, keeping the temperature at (40 +/-1) DEG C for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and before the test, so that the product is qualified.
(6) And cold resistance stability inspection, namely keeping the temperature of minus 8 +/-2 ℃ for 24h, and ensuring that no obvious character difference exists between the temperature recovered to room temperature and the temperature before the test, so that the product is qualified.
In conclusion, the stability test is passed in the range of the raw material dosage of the formula design, and the raw material meets the relevant national standard.
Antioxidant Activity test
DPPH is also called 1, 1-diphenyl-2-trinitrophenylhydrazine, is a very stable free radical with a nitrogen center, and the stability of DPPH is that due to the steric hindrance of 3 benzene rings with resonance stabilizing effect, unpaired electrons on the nitrogen atom in the middle cannot play an electron pairing effect. The absolute ethanol solution of DPPH is purple, has a maximum absorption peak at the wavelength of 517nm, and the absorbance and the concentration are in a linear relation. When the free radical scavenger is added, DPPH can be combined or replaced, so that the number of free radicals is reduced, the absorbance is reduced, the color of the solution is lightened, and the capability of scavenging the free radicals can be evaluated according to the free radical scavenger. Namely, the antioxidant capacity was calculated by measuring the DPPH-removing effect of the sample at a wavelength of 517 nm.
DPPH test solution: dissolving DPPH solid 1mg in 24mL of 95% absolute ethanol, performing ultrasonic treatment for 5min, and shaking. The DPPH solution is diluted with 0.5mL of 95% absolute ethanol to make the absorbance between 0.6 and 1.0. Sample solution of antioxidant composition: samples of the antioxidant compositions of examples 1-3 and comparative examples 1-3 were each made up to a concentration of 1mg/mL using 95% absolute ethanol solvent.
Adding 1.0mL of DPPH solution into a cuvette, adding 0.5mL of 95% absolute ethanol, diluting and mixing, and determining A value as A0(A0Must be between 0.8 and 1.0). mu.L of 95% absolute ethanol was taken in a cuvette, and 100. mu.L of a sample solution of the antioxidant composition (examples 1 to 3 and comparative examples 1 to 3) was added thereto, and 1.0mL of DPPH solution was further added thereto so that the total volume of the mixed reaction solution became 1.5mL, and the A value was measured. The average value was calculated in triplicate for each sample.
DPPH clearance calculation formula:
(A0is the value without the addition of the sample of antioxidant composition; a is the value after addition of the sample of the antioxidant composition)
The antioxidant composition free radical scavenging data is as follows:
DPPH-free radical scavenging data for antioxidant compositions
As can be seen from the test data in the above table, comparative example 3, in which the radical scavenging rate test was carried out without adding any of the cosmetic compositions, apparently did not have any radical scavenging ability; while examples 1-3 added incremental amounts of antioxidant compositions, the DPPH-radical clearance data was also increasing; the content of the antioxidant composition contained in example 1 is low, but the clearance rate is remarkably different from that of comparative example 3 without adding any antioxidant composition, which shows that the added antioxidant composition can play a good antioxidant role; under the condition of the same basic formula, the siegesbeckia pubescens Makino extract and the lycopus sieboldii fruit extract in the antioxidant composition are respectively added in the comparative example 1 and the comparative example 2, compared with the comparative example 3 (without adding any antioxidant composition), the DPPH-free radical clearance rate data is obviously different, and the fact that the antioxidant effect can be achieved by independently adding the two is shown. Compared with the DPPH and free radical scavenging rate data of example 2 (added with the antioxidant composition), the antioxidant composition obviously has better DPPH and free radical scavenging capacity than the antioxidant composition added with the antioxidant composition and has independent effect, and the synergistic effect of the antioxidant composition and the DPPH and free radical scavenging capacity is proved to be obvious. In conclusion, the antioxidant composition has an antioxidant effect.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An antioxidant composition is characterized by comprising the following components in parts by weight:
siegesbeckia pubescens extract: 0.5-2 parts;
the extract of the annona lancifolia fruits comprises the following components: 0.5-2 parts;
auxiliary agent: 4.41-24.1;
solvent: 74.9-91.59 parts.
2. The antioxidant composition of claim 1, comprising in percent:
siegesbeckia pubescens extract: 1.25 parts;
the extract of the annona lancifolia fruits comprises the following components: 1.25 parts;
auxiliary agent: 13.95 parts;
solvent: 83.55 parts.
3. The antioxidant composition of claim 2, wherein the adjuvant comprises at least one of a humectant, a stabilizer, a thickener, a preservative, a soothing agent, and a penetration enhancer.
4. The antioxidant composition of claim 2, wherein said humectant comprises at least one of panthenol, 1, 3-butylene glycol, glycerin.
5. The antioxidant composition of claim 2, wherein the stabilizer comprises disodium EDTA.
6. The antioxidant composition of claim 2, wherein the thickener comprises at least one of xanthan gum and sodium polyacrylate.
7. The antioxidant composition of claim 2, wherein the preservative comprises at least one of chlorphenesin, methyl ester, and hexylene glycol.
8. The antioxidant composition of claim 2, wherein the comfort agent comprises allantoin.
9. A process for the preparation of an antioxidant composition as claimed in any one of claims 1 to 8, characterized in that it comprises the following steps:
s1: uniformly mixing the auxiliary components, heating to 80-85 ℃, homogenizing, and keeping the temperature for 20min to obtain an auxiliary mixed solution;
s2: cooling the adjuvant mixture to below 45 deg.C, and adding Siegesbeckiae herba extract and Lycopersicon esculentum fruit extract to obtain antioxidant composition.
10. Use of the antioxidant composition of any of claims 1-8 in skin care products, including aqueous, gel, emulsion or cream type skin care products.
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