CN113303999A - Intermittent type formula low pressure hypoxemia rehabilitation physiotherapy cabin - Google Patents
Intermittent type formula low pressure hypoxemia rehabilitation physiotherapy cabin Download PDFInfo
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- CN113303999A CN113303999A CN202110570915.6A CN202110570915A CN113303999A CN 113303999 A CN113303999 A CN 113303999A CN 202110570915 A CN202110570915 A CN 202110570915A CN 113303999 A CN113303999 A CN 113303999A
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- cabin
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- cabin body
- oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
- A61G10/00—Treatment rooms or enclosures for medical purposes
- A61G10/02—Treatment rooms or enclosures for medical purposes with artificial climate; with means to maintain a desired pressure, e.g. for germ-free rooms
- A61G10/023—Rooms for the treatment of patients at over- or under-pressure or at a variable pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
Abstract
The invention relates to the technical field of medical equipment, in particular to an intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin which comprises a cabin body, a cabin door arranged on the cabin body, an air inlet unit, a vacuum pump unit and a control system for controlling the air inlet unit and the vacuum pump unit; the air outlet end of the air inlet unit is communicated with the cabin body, and the air inlet end of the vacuum pump unit is communicated with the cabin body; the intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin provided by the invention can perform intermittent low-pressure and low-oxygen alternation. Under the condition of hypoxia, the degradation of hypoxia inducible factor-1 alpha (HIF-1 alpha) is combined with HIF-1 beta subunit to form dimer, and then combined with hypoxia response element to activate the transcription of hundreds of genes in cells, thus having therapeutic effect on various diseases such as depression, insomnia, dementia, autism, arthralgia and the like.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin.
Background
The incidence of depression has a clear rising trend in the last 30 years, depression is the fourth most common depressive disorder in the world at present, depression is the main clinical feature of significant and persistent mood depression, and is the main type of mood disorder. The low mood is not matched with the situation in clinic, the depression of the mood can be from sultriness to sadness, and the self-declining depression and even the pessimism are taken away, and suicide attempts or behaviors can be caused; even the occurrence of stupor; in some cases, there is significant anxiety and motor agitation; in severe cases, psychotic symptoms such as hallucinations and delusions may occur.
At present, a plurality of antidepressant therapeutic drugs are developed in the medical field and are widely applied and verified clinically. However, these drugs have a problem that they have a long onset time, and often take a month or more to find the effect of the drug treatment; in addition, unpredictable side effects caused by long-term administration of drugs are also liable to cause burden on human bodies.
Disclosure of Invention
Aiming at the problems, the invention provides an intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin and a method thereof.
The invention is realized by the following technical scheme:
an intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin comprises a cabin body, a cabin door arranged on the cabin body, an air inlet unit, a vacuum pump unit and a control system for controlling the air inlet unit and the vacuum pump unit;
the air outlet end of the air inlet unit is communicated with the cabin body, and the air inlet end of the vacuum pump unit is communicated with the cabin body.
Further, install oxygen concentration detecting element, carbon dioxide concentration detecting element, gas flowmeter, decibel appearance, inside monitored control system, pressure detecting element in the cabin body, oxygen concentration detecting element, carbon dioxide concentration detecting element, gas flowmeter, decibel appearance, inside monitored control system, pressure detecting element all with control system electric connection.
Furthermore, one end of the cabin door is hinged to the cabin body, and the other end of the cabin door realizes the opening and locking of the cabin body and the cabin door through a cabin door lock.
Furthermore, a circle of sealing ring is arranged at the edge of the cabin door and used for improving the sealing performance of the closed cabin door.
Furthermore, the control system is connected with the air inlet unit and the vacuum pump unit in a wired or wireless mode.
Preferably, the cabin is made of non-metal materials, such as non-metal materials like plastic, glass, and ceramics.
Preferably, a plurality of circles of reinforcing ribs are uniformly arranged in the cabin body.
The intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin can be applied to treatment and rehabilitation of diseases such as depression, insomnia, autism and dementia.
Compared with the prior art, the invention has the following beneficial effects:
the intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin provided by the invention can perform intermittent low-pressure and low-oxygen alternation. Under the condition of hypoxia, the degradation of hypoxia inducible factor-1 alpha (HIF-1 alpha) is combined with HIF-1 beta subunit to form dimer, and then combined with hypoxia response element to activate the transcription of hundreds of genes in cells, thus having therapeutic effect on various diseases such as depression, insomnia, dementia, autism, arthralgia and the like. In addition, experiments show that the treatment effect of the non-metal cabin body is obviously better than that of the metal cabin body, so the intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin body is particularly preferably made of the non-metal material; compared with the existing drug therapy, the intermittent low-pressure and low-oxygen physiotherapy cabin provided by the invention has the advantages of small burden on the body and quick response, and is suitable for further popularization and application.
Drawings
FIG. 1 is a front view of the present invention;
FIG. 2 is a top view of the present invention;
FIG. 3 is a cross-sectional view of the invention A-A;
FIG. 4 is a graph showing the preference of normal and depressed mice to sugar water after low-pressure hypoxia treatment by using a metallic cabin;
FIG. 5 shows the preference of the mice for sugar water after low-pressure hypoxia treatment of normal and depressed mice by using an acrylic cabin.
The reference numbers in the figures represent respectively:
a cabin body-1; a cabin door-2; an air inlet unit-3; a vacuum pump unit-4; reinforcing ribs-11.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Referring to fig. 1-3, an intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin comprises a cabin body 1, a cabin door 2 installed on the cabin body 1, an air inlet unit 3 used for pressurizing the cabin body 1, a vacuum pump unit 4 used for depressurizing the cabin body 1, and a control system (not shown in the drawings) used for controlling the air inlet unit 3 and the vacuum pump unit 4; wherein the control system is connected with the air inlet unit 3 and the vacuum pump unit 4 in a wired or wireless mode.
The air outlet end of the air inlet unit 3 is communicated with the cabin body 1, and the air inlet end of the vacuum pump unit 4 is communicated with the cabin body 1.
Further, the cabin body 1 is made of non-metal materials, such as plastics, glass, ceramics and other non-metal materials, and a plurality of circles of reinforcing ribs 11 are uniformly arranged in the cabin body 1 and used for reinforcing the strength of the cabin body 1. The cabin body is cylindrical or square, in the embodiment, the cabin body is square, four corners of the cabin body are arc-shaped, the length of the cabin body 1 is about 4500cm, and the outer diameter of the cabin body is about 2300cm or the side length of the cabin body is 2300 cm; the wall thickness is about 5 cm; the height of the reinforcing ribs 11 is about 5 cm; the spacing between adjacent reinforcing bars 11 is 700 cm.
Further, an oxygen concentration detection unit, a carbon dioxide concentration detection unit, a gas flowmeter, a decibel meter, an internal monitoring system and a pressure detection unit (none of which is shown in the attached drawings) are installed in the cabin body 1, and the oxygen concentration detection unit, the carbon dioxide concentration detection unit, the gas flowmeter, the decibel meter, the internal monitoring system and the pressure detection unit are electrically connected with the control system; wherein the oxygen concentration detection unit adopts an oxygen concentration detector for detecting the oxygen concentration in the cabin body 1, and the carbon dioxide concentration detection unit adopts a carbon dioxide concentration detector for detecting the carbon dioxide concentration in the cabin body 1; the gas flow meter is used for monitoring the gas inlet and outlet amount of the cabin body 1, and the internal monitoring system selects a camera for monitoring the user condition in the cabin body 1; because the patient stays in the chamber body 1 to breathe and consume oxygen and discharge carbon dioxide, when the oxygen concentration detection unit detects that the oxygen concentration in the chamber body 1 is smaller than the preset value, the control system can increase the air flow of the air inlet unit 3 and the vacuum pump unit 4 under the condition of ensuring the internal pressure of the chamber body 1, accelerate the replacement of the internal gas of the chamber body 1 so as to ensure the internal oxygen concentration of the chamber body 1, and monitor the internal pressure of the chamber body in real time through the pressure detection unit in the gas inlet and outlet process.
Further, one end of the cabin door 2 is hinged to the cabin body 1, and the other end of the cabin door 2 realizes the opening and locking of the cabin body 1 and the cabin door 2 through a cabin door lock (not shown in the figure); the cabin door lock can adopt an automatic lock or a manual lock; wherein, 2 borders on the hatch door are equipped with the round sealing washer for promote the leakproofness that hatch door 2 closed.
When the physiotherapy cabin is used, a patient enters the cabin body 1 from the cabin door 2, and the air inlet unit 3 and the vacuum pump unit 4 are controlled to operate through the control system after the cabin door 2 is closed, so that an intermittent low-pressure and low-oxygen environment is formed inside the cabin body 1.
The short-time high altitude hypoxia exposure does not cause pathological changes of brain tissue organs, under the condition of acute hypoxia (i.e. hypoxia short-time stimulation), the degradation of hypoxia inducible factor-1 alpha (HIF-1 alpha) is combined with HIF-1 beta subunit to form dimer, and then combined with hypoxia response element to activate the transcription of hundreds of genes in cells, thus having quick and effective therapeutic effect on depression, insomnia, autism, arthralgia and other diseases without side effect and without damage to human body.
Experimental testing
The physical therapy cabins made of metal and nonmetal materials are respectively used for carrying out low-pressure and low-oxygen therapy on the chronic slight stress model mouse, and the experimental results are as follows:
among them, the Chronic mild stress model (CMS) is a classical animal model that simulates depression, and mice in the model show depression-like behavior with reduced carbohydrate preference (anhedonia) after receiving a series of stimuli, including restraint, ice water swimming, fasting with water deprivation, etc.
Anhedonia is the core symptom of depression, mainly manifested by loss of interest in things. Sugar water preference is often used as an index for the detection of "anhedonia" in depressed mice in animal models. Normal mice usually prefer to drink sugar water, but drink less sugar water, the sugar water preference value is more than 70%; on the contrary, depressed mice have no interest in sugar water, and have less drinking amount, more drinking amount and sugar water preference value of less than 60%.
The detection method comprises the following steps: after the experimental mouse is deprived of water for 17 hours (from the current day to 13:00) and is fasted for 5 hours (from the current day to 8:00-13:00), a bottle of water and a bottle of 1.5% sugar water are simultaneously given, the consumption of water and sugar water of the experimental mouse is respectively detected after one hour, and the sugar water consumption is compared with the total consumption of water and sugar water, namely the sugar water preference index of the experimental mouse.
Intermittent hypoxia refers to the alternation of periods of hypoxia (up to several hours) with periods of normoxic (again for several hours). Under hypoxia, the degradation of hypoxia inducible factor-1 alpha (HIF-1 alpha) is combined with HIF-1 beta subunit to form a dimer, which in turn is combined with hypoxia response elements to activate the transcription of hundreds of genes in cells. Intermittent hypoxia can increase the sweet water preference of the mice and improve the depressive behavior of the mice. The following 1) and 2) intermittent low-pressure hypoxia experiment conditions were the same.
1) Influence of metallic cabin body on behavior of depressed mouse
| Grouping | Number of examples | Mean value | Standard error of |
| |
20 | 76.02467126 | 0.705100032 |
| |
20 | 49.00151904 | 1.08804334 |
| Control+IH | 20 | 86.21008376 | 0.989090586 |
| CMS+IH | 20 | 53.81767357 | 1.239679496 |
Wherein the Control group was normal mice without depression symptoms.
As can be seen from the above table (in conjunction with fig. 4), the sugar water preference was normal in the Control group mice (mean 76.025% ± 0.705), while the CMS group mice exhibited a reduced sugar water preference after the model (mean 49.001% ± 1.088); after the two groups of mice are subjected to intermittent low-pressure hypoxia treatment for 14 days in a metal cabin, the sugar water preference of the mice in the Control + IH group is increased (86.210% + -0.989), and the sugar water preference of the mice in the CMS + IH group is slightly increased but is obviously lower than that of the mice in the Control + IH group (mean value 53.818% + -1.234).
And (4) conclusion: the metallic capsule body basically has no improvement effect on the sweet water preference of the depressed mice.
2) Influence of acrylic material (namely non-metallic material) cabin body on behavior of depression-like mice
| Grouping | Number of examples | Mean value | Standard error of |
| |
20 | 78.45328285 | 0.858123486 |
| |
20 | 47.25242155 | 1.336923372 |
| Control+IH | 20 | 88.42274979 | 0.621338419 |
| CMS+IH | 20 | 74.0092219 | 0.783777684 |
Wherein the Control group was normal mice without depression symptoms.
As can be seen from the above table (in conjunction with fig. 5), the sugar water preference was normal in the Control group mice (mean 78.453% ± 0.858), while the CMS group mice exhibited a reduced sugar water preference after the model (mean 47.252% ± 1.337); after the two groups of mice are subjected to intermittent low-pressure hypoxia treatment for 14 days in the acrylic material cabin, the sugar water preference of the mice in the Control + IH group is increased (88.423% + -0.621), and although the sugar water preference of the mice in the CMS + IH group is not restored to a normal level, the sugar water preference is obviously increased compared with the sugar water preference of the mice in the CMS group which is not subjected to intermittent low-pressure hypoxia (the average value is 74.009% + -0.784).
And (4) conclusion: the acrylic material (namely, non-metallic material) cabin body can obviously increase the sweet water preference of the mouse and obviously improve the depression-like behavior of the mouse.
In conclusion, the low-pressure and low-oxygen rehabilitation physiotherapy cabin body produced by adopting the acrylic material (namely, the non-metal material) is obviously better than the cabin body produced by the metal material in the effect of improving the depression-like behavior of the mouse; therefore, the cabin body of the low-pressure and low-oxygen rehabilitation physiotherapy cabin is preferably made of non-metallic materials.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. An intermittent low-pressure and low-oxygen rehabilitation physiotherapy cabin is characterized by comprising a cabin body (1), a cabin door (2) arranged on the cabin body (1), an air inlet unit (3), a vacuum pump unit (4) and a control system for controlling the air inlet unit (3) and the vacuum pump unit (4);
the air outlet end of the air inlet unit (3) is communicated with the cabin body (1), and the air inlet end of the vacuum pump unit (4) is communicated with the cabin body (1).
2. An intermittent type low-pressure and low-oxygen rehabilitation physiotherapy cabin according to claim 1, characterized in that, the cabin body (1) is made of non-metal material.
3. The intermittent type formula low pressure hypoxemia rehabilitation physiotherapy cabin of claim 2, characterized in that, install oxygen concentration detecting element, carbon dioxide concentration detecting element, gas flowmeter, decibel appearance, internal monitoring system, pressure detecting element in the cabin body (1), oxygen concentration detecting element, carbon dioxide concentration detecting element, gas flowmeter, decibel appearance, internal monitoring system, pressure detecting element all with control system electric connection.
4. An intermittent type low-pressure and low-oxygen rehabilitation physiotherapy cabin according to claim 2, characterized in that one end of the cabin door (2) is hinged on the cabin body (1), and the other end of the cabin door (2) realizes the opening and locking of the cabin body (1) and the cabin door (2) through a cabin door lock.
5. An intermittent type low pressure and low oxygen rehabilitation physiotherapy cabin according to claim 4, characterized in that the edge of the cabin door (2) is provided with a ring of sealing ring for improving the sealing performance of the cabin door (2) during closing.
6. An intermittent pressure swing physiotherapy cabin as claimed in claim 1, characterized in that the control system is connected with the air inlet unit (3) and the vacuum pump unit (4) in a wired or wireless manner.
7. An intermittent type low-pressure and low-oxygen rehabilitation physiotherapy cabin according to claim 2, characterized in that the cabin body (1) is provided with a plurality of circles of reinforcing ribs (11) uniformly.
8. Use of the intermittent hypoxic rehabilitation physiotherapy cabin according to any one of claims 1 to 7 for the treatment and rehabilitation of diseases.
9. The use of the intermittent low-pressure hypoxic rehabilitation physiotherapy cabin according to claim 8, wherein the diseases comprise insomnia, depression, dementia, autism.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110570915.6A CN113303999A (en) | 2021-05-25 | 2021-05-25 | Intermittent type formula low pressure hypoxemia rehabilitation physiotherapy cabin |
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| CN202110570915.6A CN113303999A (en) | 2021-05-25 | 2021-05-25 | Intermittent type formula low pressure hypoxemia rehabilitation physiotherapy cabin |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113786304A (en) * | 2021-09-28 | 2021-12-14 | 柯峰 | Application of ballast |
Citations (5)
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| US5101819A (en) * | 1991-07-11 | 1992-04-07 | Lane John C | Method for inducing hypoxia at low simulated altitudes |
| CN202860554U (en) * | 2012-10-18 | 2013-04-10 | 陕西正凡科技发展有限公司 | Small-scale plateau environment simulation cabin |
| TWM458216U (en) * | 2013-02-04 | 2013-08-01 | S J Technical Medical Co Ltd | Fixed hyperbaric oxygen chamber |
| CN208511394U (en) * | 2017-10-30 | 2019-02-19 | 安徽后青春工业设计研究院有限公司 | A kind of New Low Voltage hypoxemia cabin section structure |
| CN111111795A (en) * | 2019-12-17 | 2020-05-08 | 中国安全生产科学研究院 | Experiment cabin assembly |
-
2021
- 2021-05-25 CN CN202110570915.6A patent/CN113303999A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5101819A (en) * | 1991-07-11 | 1992-04-07 | Lane John C | Method for inducing hypoxia at low simulated altitudes |
| CN202860554U (en) * | 2012-10-18 | 2013-04-10 | 陕西正凡科技发展有限公司 | Small-scale plateau environment simulation cabin |
| TWM458216U (en) * | 2013-02-04 | 2013-08-01 | S J Technical Medical Co Ltd | Fixed hyperbaric oxygen chamber |
| CN208511394U (en) * | 2017-10-30 | 2019-02-19 | 安徽后青春工业设计研究院有限公司 | A kind of New Low Voltage hypoxemia cabin section structure |
| CN111111795A (en) * | 2019-12-17 | 2020-05-08 | 中国安全生产科学研究院 | Experiment cabin assembly |
Non-Patent Citations (2)
| Title |
|---|
| 曹雪滨: "《作训人员应激性器官损伤防治手册》", 30 April 2015, 北京：人民军医出版社 * |
| 虞积耀: "《"十二五"国家重点图书出版规划项目 海战外科学》", 31 January 2013, 北京：人民军医出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113786304A (en) * | 2021-09-28 | 2021-12-14 | 柯峰 | Application of ballast |
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