CN113277666A - Pharmaceutical water equipment meeting GMP requirements - Google Patents
Pharmaceutical water equipment meeting GMP requirements Download PDFInfo
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- CN113277666A CN113277666A CN202110674165.7A CN202110674165A CN113277666A CN 113277666 A CN113277666 A CN 113277666A CN 202110674165 A CN202110674165 A CN 202110674165A CN 113277666 A CN113277666 A CN 113277666A
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- 239000008238 pharmaceutical water Substances 0.000 title claims abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 303
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000002455 scale inhibitor Substances 0.000 claims abstract description 22
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 22
- 239000008213 purified water Substances 0.000 claims abstract description 20
- 238000003860 storage Methods 0.000 claims abstract description 12
- 239000003513 alkali Substances 0.000 claims abstract description 6
- 238000005485 electric heating Methods 0.000 claims description 66
- 239000007788 liquid Substances 0.000 claims description 20
- 238000000746 purification Methods 0.000 claims description 14
- 239000002351 wastewater Substances 0.000 claims description 7
- 238000011194 good manufacturing practice Methods 0.000 abstract description 16
- 238000002360 preparation method Methods 0.000 abstract description 5
- 238000001223 reverse osmosis Methods 0.000 abstract description 5
- 238000012423 maintenance Methods 0.000 abstract description 4
- 239000012528 membrane Substances 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000009928 pasteurization Methods 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 244000005700 microbiome Species 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000008215 water for injection Substances 0.000 description 5
- 238000001914 filtration Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000010612 desalination reaction Methods 0.000 description 3
- 239000013505 freshwater Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241001148470 aerobic bacillus Species 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 229910017053 inorganic salt Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000010963 304 stainless steel Substances 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000006004 Quartz sand Substances 0.000 description 1
- 229910000589 SAE 304 stainless steel Inorganic materials 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- RHZUVFJBSILHOK-UHFFFAOYSA-N anthracen-1-ylmethanolate Chemical compound C1=CC=C2C=C3C(C[O-])=CC=CC3=CC2=C1 RHZUVFJBSILHOK-UHFFFAOYSA-N 0.000 description 1
- 239000003830 anthracite Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002384 drinking water standard Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- -1 suspended matters Substances 0.000 description 1
- 238000011071 total organic carbon measurement Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F9/00—Multistage treatment of water, waste water or sewage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
- B01D65/022—Membrane sterilisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/08—Prevention of membrane fouling or of concentration polarisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/001—Processes for the treatment of water whereby the filtration technique is of importance
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/02—Treatment of water, waste water, or sewage by heating
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/28—Treatment of water, waste water, or sewage by sorption
- C02F1/283—Treatment of water, waste water, or sewage by sorption using coal, charred products, or inorganic mixtures containing them
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
- C02F1/441—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis by reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/66—Treatment of water, waste water, or sewage by neutralisation; pH adjustment
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/34—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32
- C02F2103/343—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32 from the pharmaceutical industry, e.g. containing antibiotics
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2301/00—General aspects of water treatment
- C02F2301/08—Multistage treatments, e.g. repetition of the same process step under different conditions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Environmental & Geological Engineering (AREA)
- Hydrology & Water Resources (AREA)
- Water Supply & Treatment (AREA)
- Water Treatment By Sorption (AREA)
- Treatment Of Water By Ion Exchange (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention discloses pharmaceutical water equipment meeting GMP (good manufacturing practice) requirements, which comprises a first water making waterway, wherein the first water making waterway is sequentially connected with a raw water tank, a raw water pump, a multi-medium filter, an activated carbon filter, a security filter, a first-stage high-pressure pump, a first-stage RO (reverse osmosis) device, a second-stage high-pressure pump, a second-stage RO device and a purified water storage tank by pipelines along the water flow direction; a scale inhibitor adding device for adding a scale inhibitor into the pipeline is arranged on the pipeline for connecting the activated carbon filter and the security filter; and a pH adjusting device for adding alkali into the pipeline is arranged on the pipeline for connecting the first-stage RO device and the second-stage high-pressure pump. The pharmaceutical water equipment meeting GMP requirements has high automation degree and convenient maintenance, has the functions of water preparation, internal circulation and disinfection, and the prepared water meets the requirements of Chinese pharmacopoeia.
Description
Technical Field
The invention belongs to the field of water production equipment, and particularly relates to pharmaceutical water equipment meeting GMP (good manufacturing practice) requirements.
Background
From the 2000 th edition, the pharmacopoeia of the people's republic of china (abbreviated as the chinese pharmacopoeia) collects pharmaceutical water which is classified into drinking water, purified water, water for injection and water for sterilization and injection according to the use range, the purified water replaces the distilled water, and the purified water is prepared by distilling the drinking water, performing ion exchange, performing reverse osmosis or other suitable methods, and does not contain any additive. So far, the production of Chinese medicinal water can adopt an advanced membrane separation method for the first time.
Thereafter, compared with the version of 2000, the 2005 version of the chinese pharmacopoeia has more strict requirements on the physical and chemical limit indexes of heavy metals in the examination items of the collected "purified water" and "water for injection", and the indexes of other examination items have no change, but the microbial limit indexes are increased, that is, the total number of bacteria, mold and yeast does not exceed 100 in every 1ml of "purified water", and the total number of bacteria, mold and yeast does not exceed 10 in every 100ml of "water for injection", showing that the national requirements on the quality of medicinal water are more and more strict. The microorganism limit index puts higher requirements on the preparation process of the pharmaceutical water and the operation and maintenance of equipment.
With the progress of science and technology, the 2010 version of the Chinese pharmacopoeia has changed greatly, in the appendix of the two parts, 64 descriptions and measurement methods are added, including relevant sections of pharmaceutical water, pH value measurement method, pharmaceutical water conductivity measurement method, pharmaceutical water total organic carbon measurement method and the like, and two items of conductivity and total organic carbon are added in the inspection items of 'purified water' and 'water for injection'.
The Chinese pharmacopoeia 2015 edition continues the regulation and requirements of the 2010 edition on the contents, and does not substantially change, only the total number of bacteria, mold and yeast is not distinguished any more only for the microbial limit indexes, but the R2A agar culture medium is adopted, the culture is carried out for not less than 5 days at 30-35 ℃, the total number of aerobic bacteria in each 1ml of purified water treated by a membrane filtration method is not more than 100, and the total number of aerobic bacteria in 100ml of water for injection is not more than 10.
For pharmaceutical water preparation systems, microbial control in the water treatment process is consistent throughout the entire process. Therefore, according to the function and the characteristics of water treatment equipment adopted in the system for preparing the pharmaceutical water for process, proper necessary measures are selected to control and reduce the pollution of microorganisms.
Disclosure of Invention
The invention provides a pharmaceutical water device meeting GMP requirements, which comprises: the system comprises a first water making waterway, a first water making waterway and a second water making waterway, wherein the first water making waterway is sequentially connected with a raw water tank, a raw water pump, a multi-medium filter, an activated carbon filter, a cartridge filter, a first-stage high-pressure pump, a first-stage RO device, a second-stage high-pressure pump, a second-stage RO device and a purified water storage tank by pipelines along the water flow direction;
a scale inhibitor adding device for adding a scale inhibitor into the pipeline is arranged on the pipeline for connecting the activated carbon filter and the security filter;
and a pH adjusting device for adding alkali into the pipeline is arranged on the pipeline for connecting the first-stage RO device and the second-stage high-pressure pump.
Further, the pharmaceutical water equipment comprises a second water making waterway, and the second water making waterway comprises an electric heating heat exchanger;
the electric heating heat exchanger is arranged between the cartridge filter and the primary high-pressure pump;
and the water inlet end and the water outlet end of the electric heating heat exchanger are respectively connected with the security filter and the primary high-pressure pump pipeline.
Furthermore, the concentrated water outlet end of the secondary RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline.
Furthermore, the concentrated water outlet end of the first-stage RO device is connected with a waste water pipe through a pipeline.
Further, the pharmaceutical water equipment also comprises an internal circulation loop;
the inner circulation loop is sequentially connected with a raw water tank, a raw water pump, a multi-media filter, an activated carbon filter, a security filter, an electric heating heat exchanger, a first-stage high-pressure pump, a first-stage RO device, a second-stage high-pressure pump and a second-stage RO device through pipelines along the water flow direction, and the water outlet end of the second-stage RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline.
Furthermore, the concentrated water outlet end of the first-stage RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline;
and the concentrated water outlet end of the secondary RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline.
Further, the pharmaceutical water equipment also comprises a pretreatment disinfection loop;
the pretreatment disinfection loop is sequentially connected with a raw water tank, a raw water pump, a multi-medium filter, an activated carbon filter, a security filter and an electric heating heat exchanger by pipelines along the water flow direction;
the water outlet end of the electric heating heat exchanger is connected with the water inlet end of the raw water tank through a pipeline;
the electric heating heat exchanger heats water until the water temperature reaches a first temperature.
Further, the pharmaceutical water equipment further comprises a purification device disinfection circuit;
the purification device disinfection loop is sequentially connected with an electric heating heat exchanger, a first-stage high-pressure pump, a first-stage RO device, a second-stage high-pressure pump and a second-stage RO device through pipelines along the water flow direction;
the water outlet end of the secondary RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline;
the electric heating heat exchanger heats water until the water temperature reaches a second temperature.
Furthermore, the concentrated water outlet end of the first-stage RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline;
and the concentrated water outlet end of the secondary RO device is connected with the water inlet end of the electric heating heat exchanger through a pipeline.
Further, the pharmaceutical water device further comprises an alarm system;
the pharmaceutical water equipment detects liquid level, pressure, temperature and conductivity;
presetting a liquid level threshold, a pressure threshold, a temperature threshold and a conductivity threshold,
when the liquid level in the pharmaceutical water equipment is greater than the liquid level threshold value and/or
Pressure > pressure threshold and/or
Temperature > temperature threshold and/or
When the conductivity > the conductivity threshold value,
the alarm system alarms.
The pharmaceutical water equipment meeting GMP requirements has high automation degree and convenient maintenance, has the functions of water preparation, internal circulation and disinfection, and the prepared water meets the requirements of Chinese pharmacopoeia.
Drawings
FIG. 1 is a schematic diagram of a GMP compliant pharmaceutical water facility according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a second water circuit of a GMP compliant pharmaceutical water facility in accordance with an embodiment of the present invention;
FIG. 3 is a schematic diagram of a portion of the water flow of a recirculation loop within a GMP compliant pharmaceutical water facility in accordance with an embodiment of the present invention;
FIG. 4 shows a schematic diagram of a pre-treatment disinfection circuit flow for a GMP compliant pharmaceutical water facility in accordance with an embodiment of the present invention;
figure 5 shows a schematic diagram of the disinfection circuit water flow of a GMP compliant pharmaceutical water plant purification apparatus in accordance with an embodiment of the present invention.
In the figure: 01. a first valve; 02. a second valve; 03. a third valve; 04. a fourth valve; 05. a fifth valve; 06. a sixth valve; 07. a seventh valve; 08. an eighth valve; 09. a ninth valve; 010. a tenth valve; 011. an eleventh valve; 012. a tenth valve; 013. a tenth valve; 1. a raw water tank; 2. a raw water pump; 3. a multi-media filter; 4. an activated carbon filter; 5. a scale inhibitor adding device; 6. a cartridge filter; 7. an electrically heated heat exchanger; 8. a first stage high pressure pump; 9. a first-stage RO device; 10. a second stage high pressure pump; 11. a pH adjusting device; 12. a secondary RO device; 13. and (5) a purified water storage tank.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
The invention provides a pharmaceutical water device meeting GMP requirements, as shown in figure 1, comprising:
the raw water tank 1 is provided with a water inlet valve at the water inlet end and is connected with a pipeline at the water inlet end of the raw water pump 2 at the water outlet end;
the water outlet end of the raw water pump 2 is connected with the water inlet end of the multi-media filter 3 through a pipeline;
the water outlet end of the multi-media filter 3 is connected with the water inlet end of the activated carbon filter 4 through a pipeline;
the water outlet end of the activated carbon filter 4 is connected with the water inlet end of the cartridge filter 6 through a pipeline;
a scale inhibitor adding device 5 for adding scale inhibitor into the pipeline is arranged on the pipeline connecting the activated carbon filter 4 and the security filter 6;
the water outlet end of the cartridge filter 6 is respectively connected with the first end of the first valve 01 and the first end of the second valve 02 through pipelines;
the second end of the second valve 02 is connected with a water inlet end pipeline of the electric heating heat exchanger 7;
the water outlet end of the electric heating heat exchanger 7 is respectively connected with the first end of the third valve 03 and the first end of the fourth valve 04 through pipelines;
the second end of the third valve 03 is connected with a water inlet end pipeline of the primary high-pressure pump 8;
the second end of the first valve 01 and the second end of the fourth valve 04 are connected with the water inlet end of the raw water tank 1 through pipelines;
the water outlet end of the first-stage high-pressure pump 8 is connected with the water inlet end of the first-stage RO device 9 through a pipeline;
the water outlet end of the first-stage RO device 9 is connected with the water inlet end of the second-stage high-pressure pump 10 through a pipeline;
the concentrated water outlet end of the first-stage RO device 9 is connected with the first end of the eighth valve 08 and the first end of the ninth valve 09 through pipelines;
the second end of the eighth valve 08 is connected with a water inlet end pipeline of the electric heating heat exchanger 7;
a check valve is arranged between the concentrated water outlet end of the first-stage RO device 9 and the first end of the eighth valve 08, and water flow can only flow from the concentrated water outlet end of the first-stage RO device 9 to the first end of the eighth valve 08;
the second end of the ninth valve 09 is connected with a waste water port pipeline; a check valve is arranged between the concentrated water outlet end of the first-stage RO device 9 and the first end of the ninth valve 09, and water flow can only flow from the concentrated water outlet end of the first-stage RO device 9 to the first end of the ninth valve 09;
a pH adjusting device 11 for adding alkali into the pipeline is arranged on the pipeline connecting the first-stage RO device 9 and the second-stage high-pressure pump 10; preferably, the base is NaOH;
the water outlet end of the second-stage high-pressure pump 10 is connected with the water inlet end of the second-stage RO device 12 through a pipeline;
the water inlet end of the second-stage high-pressure pump 10 is connected with a first end pipeline of the tenth valve 010, and the water outlet end of the second-stage high-pressure pump 10 is connected with a second end pipeline of the tenth valve 010;
the water outlet end of the secondary RO device 12 is connected with the first end of a thirteenth valve 013 through a pipeline;
the concentrated water outlet end of the secondary RO device 12 is connected with the first end of an eleventh valve 011 and the first end of a twelfth valve 012 through pipelines;
the second end of the eleventh valve 011 is connected with a waste water port pipeline;
the second end of the twelfth valve 012 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline;
the second end of the thirteenth valve 013 is connected with the water inlet end of the purified water storage tank 13 through a pipeline;
a first end of a thirteenth valve 013 is in pipeline connection with a first end of a fifth valve 05, a second end of the fifth valve 05, a first end of a sixth valve 06 and a first end of a seventh valve 07;
a second end of the sixth valve 06 is connected with a second end of the second valve 02 through a pipeline;
and a second end of the seventh valve 07 is connected with a waste water port pipeline.
Preferably, the first valve 01, the third valve 03, the fourth valve 04, and the eleventh valve 011 are pneumatic butterfly valves. The second valve 02 is a pneumatic proportional regulating valve. The fifth valve 05, the sixth valve 06, the seventh valve 07, and the thirteenth valve 013 are pneumatic diaphragm valves. The eighth valve 08, the ninth valve 09, the tenth valve 010, and the tenth valve 012 are manual angle seat valves.
The pharmaceutical water equipment comprises a second water making waterway, as shown in figure 2, wherein the second water making waterway is sequentially connected with a raw water tank 1, a raw water pump 2, a multi-media filter 3, an activated carbon filter 4, a security filter 6, an electric heating heat exchanger 7, a primary high-pressure pump 8, a primary RO device 9, a secondary high-pressure pump 10, a secondary RO device 12 and a purified water storage tank 13 by pipelines along the water flow direction; a scale inhibitor adding device 5 for adding scale inhibitor into the pipeline is arranged on the pipeline connecting the activated carbon filter 4 and the security filter 6; and a pH adjusting device 11 for adding alkali into the pipeline is arranged on the pipeline connecting the first-stage RO device 9 and the second-stage high-pressure pump 10. And the concentrated water outlet end of the secondary RO device 12 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline. And the concentrated water outlet end of the first-stage RO device 9 is connected with a waste water pipe through a pipeline.
When the first valve 01, the third valve 03 and the fourth valve 04 are opened and the 02 valve is closed, the water is a first water production waterway, and a raw water tank 1, a raw water pump 2, a multimedia filter 3, an activated carbon filter 4, a security filter 6, a first-stage high-pressure pump 8, a first-stage RO device 9, a second-stage high-pressure pump 10, a second-stage RO device 12 and a purified water storage tank 13 are sequentially connected by pipelines along the water flow direction; a scale inhibitor adding device 5 for adding scale inhibitor into the pipeline is arranged on the pipeline connecting the activated carbon filter 4 and the security filter 6; and a pH adjusting device 11 for adding alkali into the pipeline is arranged on the pipeline connecting the first-stage RO device 9 and the second-stage high-pressure pump 10. And the concentrated water outlet end of the secondary RO device 12 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline. And the concentrated water outlet end of the first-stage RO device 9 is connected with a waste water pipe through a pipeline.
When the invention is used for preparing water, the water is pretreated firstly and then is further purified, and finally high-quality pharmaceutical water meeting the requirements of Chinese pharmacopoeia is generated.
The raw water pretreatment is to carry out pretreatment on raw water by adopting a certain physical or chemical method on the basis of analyzing the water quality of municipal water supply, so that the raw water Silt Density Index (SDI) is reduced, and the content of chemical components such as residual chlorine in the raw water is reduced, thereby meeting the water quality requirement of water inlet of an RO membrane system, improving the working efficiency of the RO membrane system and prolonging the service life of the RO membrane system.
The pretreated raw water enters a purification device (RO + RO), and then enters a primary RO system for pre-desalination to remove most inorganic salt ions, microorganisms and bacteria, and then enters a secondary RO system for further removing part of residual inorganic salt ions, microorganisms and bacteria, so that stable produced water with the concentration of less than 5.1 mu S/cm is reduced and obtained, and the requirements of continuous and stable high-standard water quality with low conductivity, low bacteria content and low bacterial endotoxin are met.
The device for pretreatment of the first water production waterway and the second water production waterway comprises a raw water tank 1, a raw water pump 2, a multi-medium filter 3, an activated carbon filter 4, a scale inhibitor adding device 5, a security filter 6 and related pipelines, and corresponding instruments are arranged in the pipelines and used for measuring liquid level, pressure, temperature and conductivity.
The raw water tank 1 is used for storing raw water, an automatic water inlet valve for preventing a water hammer is arranged, a liquid level sensor is arranged for monitoring the liquid level of the raw water tank, and the starting and stopping of the raw water pump and the opening and closing of the automatic water inlet valve are automatically controlled.
The raw water pump 2 is a vertical multi-stage centrifugal pump, can be controlled by frequency conversion, and sends the raw water tank 01 into the multi-media filter 03 at different speeds according to requirements. Preferably, the material is SUS304(304 stainless steel).
The multi-medium filter 3 is mainly filled with two different filter materials of quartz sand and anthracite, and large-particle impurities, suspended matters, colloids and the like in water are removed by utilizing the effects of membrane filtration, osmotic filtration and contact filtration. When the water inlet pressure difference and the water outlet pressure difference of the multi-media filter 3 reach a set value or the accumulated running time reaches a set value, the multi-media filter needs to be backwashed to reduce the filtering resistance of the multi-media filter.
The activated carbon filter 4 is mainly used for removing free residual chlorine, microorganisms, organic matters, partial heavy metals and other harmful substances in raw water through the adsorption capacity of capillary pores on the surface of activated carbon. When the adsorption of the activated carbon filter 4 tends to saturation, the activated carbon needs to be backwashed in time.
The scale inhibitor adding device 5 is mainly used for adding scale inhibitors to prevent the concentrated water side of the RO membrane from scaling due to concentration when the RO membrane selectively permeates fresh water. Mainly comprises a scale inhibitor metering pump and a scale inhibitor metering box. The scale inhibitor metering box is used for placing scale inhibitor, and the scale inhibitor metering pump is used for controlling the specific metering of adding the scale inhibitor.
The cartridge filter 6 is used for removing leaked particulate impurities and preventing scratching of the RO membrane, and has a filtration precision of 5.0 μm. The cartridge filter 6 housing is made of SUS304 stainless steel.
In the second water making waterway, the electric heating heat exchanger 7 is equivalent to a common pipeline.
The devices of the first water making waterway and the second water making waterway which are designed by the invention and are used for purification comprise a primary high-pressure pump 8, a primary RO device 9, a secondary high-pressure pump 10, a pH adjusting device 11, a secondary RO device 12, a purified water storage tank 13 and related pipelines, and corresponding instruments are also arranged in the pipelines and are used for measuring liquid level, pressure, temperature and conductivity.
The first stage high pressure pump 8 and the second stage high pressure pump 10 are used for providing a transverse and longitudinal water inlet pressure for the RO membrane, the longitudinal pressure is higher than the osmotic pressure of water, the fresh water penetrates through the RO membrane and enters the fresh water side, and the transverse pressure enables the water to flow forwards to prevent the water from depositing and scaling on the concentrated water side of the RO membrane. Preferably, the first-stage high-pressure pump 8 and the second-stage high-pressure pump 10 both have a frequency conversion function.
The first-stage RO device 9 and the second-stage RO device 12 both use RO desalination, and by means of the membrane separation technology of selecting permeable (semi-permeable) membrane and using pressure difference as driving force, when the pressure applied in the system is greater than the osmotic pressure of the solution, the water molecules continuously permeate the membrane, flow into the central tube through the water production flow channel, then flow out at the water outlet end, and the impurities in the inlet water, such as ions, organic matters, bacteria, viruses, etc. are trapped at the water inlet side of the membrane, and then flow out at the concentrated water end, thereby achieving the purpose of separation and desalination.
The concentrated water produced by the second-stage RO device 12 is pure, even the water quality is better than that of the pretreated raw water, the eleventh valve 011 is closed, the twelfth valve 012 is opened, and the concentrated water outlet end is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline.
The pH adjusting device 11 is used for adding sodium hydroxide (NaOH) into the first-stage RO water to increase the pH value, so that carbon dioxide in the water is completely converted into bicarbonate ions (the RO membrane is used for gas CO)2No removing effect on HCO3 -Greater than 99%).
The purified water storage tank 13 is used for storing purified water and is provided with a liquid level sensor for monitoring the liquid level of the purified water storage tank. Preferably, the start and stop of the purification device can be automatically controlled.
The pipeline and the valve from the raw water (the quality of the raw water must meet the drinking water standard of urban life) to the secondary RO water production are made of sanitary SS304 stainless steel, and the pipeline and the valve from the secondary RO water production (without the concentrated water pipeline) to the purified water storage tank are made of sanitary SS316L stainless steel.
When the purified water storage tank 13 has high liquid level and does not need water, the pharmaceutical water equipment designed by the invention operates in an internal circulation loop mode, and finally, the produced water automatically flows back to the first-stage RO water inlet to keep small-flow internal circulation so as to reduce the possibility of bacterial breeding and control microorganisms.
The first valve 01, the fourth valve 04, the seventh valve 07, the ninth valve 09, the tenth valve 010, the eleventh valve 011, and the thirteenth valve 013 are closed; the second valve 02, the third valve 03, the fifth valve 05, the sixth valve 06, the eighth valve 08, and the twelfth valve 012 are opened. The purification treatment is as shown in fig. 3, the inner circulation loop is sequentially connected with a raw water tank 1, a raw water pump 2, a multi-media filter 3, an activated carbon filter 4, a cartridge filter 6, an electric heating heat exchanger 7, a primary high-pressure pump 8, a primary RO device 9, a secondary high-pressure pump 10 and a secondary RO device 12 through pipelines along the water flow direction, and the water outlet end of the secondary RO device 12 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline. The concentrated water outlet end of the first-stage RO device 9 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline; and the concentrated water outlet end of the secondary RO device 12 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline.
The internal circulation loop is jointly opened and closed by an automatic control device of the equipment and each valve installed, the pneumatic proportional control valve is at the minimum opening, the high-pressure pump runs in a uniform frequency conversion mode, and the RO produced water and the RO concentrated water return to the RO water inlet.
In order to meet GMP requirements, pasteurization is adopted as a sterilization measure of pharmaceutical water equipment, and the raw water is periodically heated to a multi-medium filter, an activated carbon filter, an RO purification device and the like for online pasteurization. Pasteurization is carried out at a temperature of 80-85 deg.C for 30min, preferably 81 deg.C, 40 min. An electrically heated heat exchanger 7 is therefore provided. Preferably, the water inlet end and the water outlet end of the electric heating heat exchanger 7 are both provided with temperature sensors.
The pharmaceutical water equipment designed by the invention respectively disinfects the pretreatment part and the purification part in the equipment, shares one electric heating heat exchanger 7 to finish pasteurization operation, and carries out disinfection in sections. At this time, the electric heating heat exchanger 7 can heat the line water.
The pretreatment disinfection loop and the purification device disinfection loop are jointly completed by an automatic control device of equipment and the opening and closing of each valve, the related pumps run in a variable frequency mode, and the electric heating heat exchanger 7 continuously works until the water temperature is increased to 81 ℃.
When the pretreatment portion is sterilized, a pretreatment sterilizing circuit is used. The first valve 01, the third valve 03 and the sixth valve 06 are closed; the second valve 02 and the fourth valve 04 are opened, as shown in fig. 4, the pretreatment disinfection loop is sequentially connected with a raw water tank 1, a raw water pump 2, a multi-media filter 3, an activated carbon filter 4, a security filter 6 and an electric heating heat exchanger 7 by pipelines along the water flow direction; the water outlet end of the electric heating heat exchanger 7 is connected with the water inlet end of the raw water tank 1 through a pipeline; the electric heating heat exchanger 7 heats water until the water temperature reaches a first temperature. Preferably, the first temperature is 81 ℃.
The pasteurization process for the pretreatment portion was as follows:
1. the raw water pump 2 is started, and raw water in the raw water tank 1 is pressurized and then passes through the multi-media filter 3, the activated carbon filter 4 and the cartridge filter 6;
2. when the water passing through the cartridge filter 6 passes through the electric heating heat exchanger 7, the temperature of the raw water is gradually increased, and then the water flows back to the raw water tank 1;
3. temperature sensors are arranged at the water inlet end and the water outlet end of the electric heating heat exchanger 7, the system automatically monitors the temperature sensor at the water outlet end of the electric heating heat exchanger 7, and the water outlet temperature is controlled to be a certain numerical value between 81 ℃ and 85 ℃ at constant temperature;
4. the system automatically monitors a water inlet end temperature sensor of the electric heating heat exchanger 7 (the temperature is the lowest pasteurization temperature of the activated carbon filter 4), and starts timing when reaching 81 ℃ and keeps constant temperature for a duration not less than 40 min;
5. and presetting a first fluctuation threshold, and if the temperature fluctuation exceeds the first fluctuation threshold in the constant temperature duration of 81 ℃, the system records the constant temperature duration from zero.
The second valve 02, the fourth valve 04, the seventh valve 07, the ninth valve 09, the tenth valve 010, the eleventh valve 011, the thirteenth valve 013 are closed; the third valve 03, the fifth valve 05, the sixth valve 06, the eighth valve 08 and the twelfth valve 012 are opened, as shown in fig. 5, the electric heating heat exchanger 7, the first-stage high-pressure pump 8, the first-stage RO device 9, the second-stage high-pressure pump 10 and the second-stage RO device 12 are sequentially connected to the purification device disinfection circuit by pipelines along the water flow direction; the water outlet end of the secondary RO device 12 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline; the electric heating heat exchanger 7 heats the water until the water temperature reaches a second temperature. The concentrated water outlet end of the first-stage RO device 9 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline; and the concentrated water outlet end of the secondary RO device 12 is connected with the water inlet end of the electric heating heat exchanger 7 through a pipeline. Preferably, the second temperature is 81 ℃. Preferably, the water outlet end of the secondary RO device 12 is provided with a temperature sensor.
The pasteurization process for the purified fraction was as follows:
1. the raw water pump 2 is started, and the pretreatment part of the pharmaceutical water equipment starts to work normally;
2. when raw water passes through the electric heating heat exchanger 7, the raw water is gradually heated, then is pressurized by the first-stage high-pressure pump 8 and then enters the first-stage RO device 9;
3. the concentrated water of the first-stage RO device 9 flows back to the water inlet end of the electric heating heat exchanger 7; the produced water enters a secondary RO device 12 after being pressurized by a secondary high-pressure pump 10;
4. the produced water of the second-stage RO device 12 flows back to the water inlet end of the electric heating heat exchanger 7, and the concentrated water of the second-stage RO device 12 flows back to the water inlet end of the electric heating heat exchanger 7;
5. the system automatically monitors the temperature sensor at the water outlet end of the electric heating heat exchanger 7, and controls the water outlet temperature to be a certain numerical value between 81 ℃ and 85 ℃ at constant temperature;
6. the system automatically monitors a temperature sensor at the water outlet end of the secondary RO (the temperature is the lowest point of the primary and secondary RO pasteurization temperatures), and starts to time for constant temperature duration not less than 40min when reaching 81 ℃;
7. and presetting a second fluctuation threshold, and if the temperature fluctuation exceeds the preset second fluctuation threshold in the constant temperature duration of 81 ℃, restarting recording the constant temperature duration by the system from zero.
The pharmaceutical water equipment designed by the invention also comprises an alarm system; the device is characterized in that various sensors are arranged at all positions of the whole device, liquid level, pressure, temperature and conductivity are detected, a liquid level threshold value, a pressure threshold value, a temperature threshold value and a conductivity threshold value are preset, and an alarm system alarms when the liquid level in the pharmaceutical water device is greater than the liquid level threshold value and/or the pressure is greater than the pressure threshold value and/or the temperature is greater than the temperature threshold value and/or the conductivity is greater than the conductivity threshold value. The alarm includes, but is not limited to, an audible alarm for drawing the attention of the operator. The alarm system can also give prompt information, and an operator can deal with corresponding problems according to the information prompt. Further, the alarm system can forcibly shut down the entire pharmaceutical water facility.
The pharmaceutical water equipment designed by the invention is also provided with an automatic control device, and the automatic control device can read the information of each sensor, control the closing and opening of each valve and control the variable-frequency operation of each pump. Furthermore, the automatic control device can automatically control the corresponding valves to be closed and opened, and corresponding equipment runs, so that the first water making waterway, the second water making waterway, the internal circulation loop, the pretreatment disinfection loop and the purification device disinfection loop are finally realized respectively.
Preferably, the automatic control device further comprises a PLC and a touch screen, so that an operator can operate, monitor and control the equipment conveniently. The operator can control the management device through the touch screen, and can read basic parameters of the management device, such as conductivity, pressure, temperature, liquid level control and the like.
The pharmaceutical water equipment meeting GMP requirements has high automation degree and convenient maintenance, has the functions of water preparation, internal circulation and disinfection, and the prepared water meets the requirements of Chinese pharmacopoeia.
The above are merely examples of the present application and are not intended to limit the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.
Claims (10)
1. The pharmaceutical water equipment meeting GMP requirements is characterized by comprising a first water making waterway, wherein the first water making waterway is sequentially connected with a raw water tank (1), a raw water pump (2), a multi-medium filter (3), an activated carbon filter (4), a security filter (6), a first-stage high-pressure pump (8), a first-stage RO device (9), a second-stage high-pressure pump (10), a second-stage RO device (12) and a purified water storage tank (13) by pipelines along the water flow direction;
a scale inhibitor adding device (5) for adding a scale inhibitor into the pipeline is arranged on the pipeline connecting the activated carbon filter (4) and the security filter (6);
a pH adjusting device (11) for adding alkali into the pipeline is arranged on the pipeline connecting the first-stage RO device (9) and the second-stage high-pressure pump (10).
2. The pharmaceutical water device of claim 1,
the pharmaceutical water equipment comprises a second water making waterway, and the second water making waterway comprises an electric heating heat exchanger (7);
the electric heating heat exchanger (7) is arranged between the security filter (6) and the primary high-pressure pump (8);
the water inlet end and the water outlet end of the electric heating heat exchanger (7) are respectively connected with the security filter (6) and the first-stage high-pressure pump (8) through pipelines.
3. A pharmaceutical water use apparatus according to claim 2,
and the concentrated water outlet end of the secondary RO device (12) is connected with the water inlet end of the electric heating heat exchanger (7) through a pipeline.
4. A pharmaceutical water device according to claim 3,
and the concentrated water outlet end of the primary RO device (9) is connected with a waste water pipe through a pipeline.
5. A pharmaceutical water use apparatus according to claim 2,
the pharmaceutical water equipment also comprises an internal circulation loop;
the inner circulation loop is sequentially connected with a raw water tank (1), a raw water pump (2), a multi-medium filter (3), an activated carbon filter (4), a security filter (6), an electric heating heat exchanger (7), a primary high-pressure pump (8), a primary RO device (9), a secondary high-pressure pump (10) and a secondary RO device (12) through pipelines along the water flow direction, and the water outlet end of the secondary RO device (12) is connected with the water inlet end pipeline of the electric heating heat exchanger (7).
6. A pharmaceutical water use apparatus according to claim 5,
the concentrated water outlet end of the first-stage RO device (9) is connected with the water inlet end of the electric heating heat exchanger (7) through a pipeline;
and the concentrated water outlet end of the secondary RO device (12) is connected with the water inlet end of the electric heating heat exchanger (7) through a pipeline.
7. A pharmaceutical water use apparatus according to claim 2,
the pharmaceutical water equipment also comprises a pretreatment disinfection loop;
the pretreatment disinfection loop is sequentially connected with a raw water tank (1), a raw water pump (2), a multi-medium filter (3), an activated carbon filter (4), a security filter (6) and an electric heating heat exchanger (7) through pipelines along the water flow direction;
the water outlet end of the electric heating heat exchanger (7) is connected with the water inlet end of the raw water tank (1) through a pipeline;
the electric heating heat exchanger (7) heats water until the water temperature reaches a first temperature.
8. A pharmaceutical water use apparatus according to claim 2,
the pharmaceutical water equipment also comprises a purification device disinfection loop;
the purification device disinfection loop is sequentially connected with an electric heating heat exchanger (7), a first-stage high-pressure pump (8), a first-stage RO device (9), a second-stage high-pressure pump (10) and a second-stage RO device (12) through pipelines along the water flow direction;
the water outlet end of the secondary RO device (12) is connected with the water inlet end of the electric heating heat exchanger (7) through a pipeline;
the electric heating heat exchanger (7) heats water until the water temperature reaches a second temperature.
9. A pharmaceutical water use apparatus according to claim 8,
the concentrated water outlet end of the first-stage RO device (9) is connected with the water inlet end of the electric heating heat exchanger (7) through a pipeline;
and the concentrated water outlet end of the secondary RO device (12) is connected with the water inlet end of the electric heating heat exchanger (7) through a pipeline.
10. A pharmaceutical water unit according to any one of claims 1 to 9,
the pharmaceutical water equipment further comprises an alarm system;
the pharmaceutical water equipment detects liquid level, pressure, temperature and conductivity;
presetting a liquid level threshold, a pressure threshold, a temperature threshold and a conductivity threshold,
when the liquid level in the pharmaceutical water equipment is greater than the liquid level threshold value and/or
Pressure > pressure threshold and/or
Temperature > temperature threshold and/or
When the conductivity > the conductivity threshold value,
the alarm system alarms.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011212628A (en) * | 2010-04-01 | 2011-10-27 | Mitsubishi Rayon Cleansui Co Ltd | Purified water producing apparatus |
| CN207845415U (en) * | 2018-01-26 | 2018-09-11 | 济南海德水处理设备有限公司 | A kind of pharmaceutical bipolar reverse osmosis equipment |
| CN216837505U (en) * | 2021-06-17 | 2022-06-28 | 军事科学院系统工程研究院卫勤保障技术研究所 | Pharmaceutical water equipment meeting GMP requirements |
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- 2021-06-17 CN CN202110674165.7A patent/CN113277666A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011212628A (en) * | 2010-04-01 | 2011-10-27 | Mitsubishi Rayon Cleansui Co Ltd | Purified water producing apparatus |
| CN207845415U (en) * | 2018-01-26 | 2018-09-11 | 济南海德水处理设备有限公司 | A kind of pharmaceutical bipolar reverse osmosis equipment |
| CN216837505U (en) * | 2021-06-17 | 2022-06-28 | 军事科学院系统工程研究院卫勤保障技术研究所 | Pharmaceutical water equipment meeting GMP requirements |
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