CN113274372A - Preparation method of microneedle patch for quickly and efficiently relieving itching due to mosquito bites - Google Patents
Preparation method of microneedle patch for quickly and efficiently relieving itching due to mosquito bites Download PDFInfo
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- CN113274372A CN113274372A CN202110531744.6A CN202110531744A CN113274372A CN 113274372 A CN113274372 A CN 113274372A CN 202110531744 A CN202110531744 A CN 202110531744A CN 113274372 A CN113274372 A CN 113274372A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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Abstract
The invention discloses a preparation method of a rapid and efficient itching relieving microneedle patch for mosquito bites. The effective itching relieving essence and the substrate antibacterial and anti-inflammatory essence film contain the following components: PVA, tea tree oil and polyvinyl pyrrolidone. The tea tree oil has the functions of resisting bacteria, diminishing inflammation and relieving itching, and has good effects of promoting mosquito bites to relieve itching, diminishing inflammation and repairing. The tea tree oil is dissolved in the microneedle and the microneedle backing to prepare the soluble microneedle, so that the double-effect antipruritic effect is achieved on the inside and the outside of the skin, and the antipruritic process is efficient and simple. The itching-relieving microneedle patch has no irreversible damage to human bodies and is green and environment-friendly.
Description
Technical Field
The invention belongs to the field of microneedles, and particularly relates to a preparation method of a rapid and efficient itching-relieving microneedle patch for mosquito bites.
Background
In temperate regions, mosquito bites in summer are a bothersome. It has been proposed in the early 18 th century that mosquito saliva will contain toxic substances. When mosquitoes bite, saliva can be injected into the skin, the human reactions are similar, the mosquitoes are usually very itchy and difficult to endure, bleeding and scabbing can occur when scratching and breaking the skin, scars and scratching can be left on severe people, and pathogenic bacteria infection is often caused by scratching and scratching indirection. The sensitive skin can be scratchy and itchy, vicious circle can be generated, and tissues in the dermis layer can be damaged to form scars; the children are easy to have emotional irritability and crying, such as local red swelling, purulence, redness, even fever, etc.
Microneedles are miniature injectors used to inject vaccines or other drugs through various barriers. Microneedles are constructed by various methods, typically involving photolithographic processes or micromolding. The method mainly involves etching the microneedle structure onto the silicone by an etching method to fabricate microneedles. In 1998, the concept of microneedles was first mentioned in the Sebastien Henry et al study, demonstrating that microneedles can penetrate human skin. Since then, researchers have designed and explored their applications in the medical and cosmetic fields. The primary goal of any microneedle design is to penetrate the stratum corneum, the most superficial layer of the skin. Because the metal micro-needle is easy to break to cause skin infection, people update the design of the micro-needle, namely, the drug is wrapped in the nontoxic polymer soluble micro-needle, and once the micro-needle penetrates into the skin, the micro-needle is dissolved and decomposed, thereby achieving the aim of releasing the drug transdermally. Therefore, more functional soluble microneedles have been developed.
Tea tree oil, also known as tea tree essential oil, is a natural plant essential oil and has broad-spectrum antibacterial property. Tea tree oil is a natural disinfectant, and is helpful for treating many diseases and wounds. Such as cuts, abrasions, bites by insects, acne, burns, and the like.
At present, the application of the microneedle is lack of the application of the microneedle for relieving itching caused by mosquito bites, most products still adopt an external mode for relieving itching, the effect is limited, the itching feeling can be repeated, and even scars can be caused by continuous scratching. Therefore, a new itching relieving method is needed, which is innovative and improved, improves the itching relieving effect and eliminates repeated itching feeling.
Disclosure of Invention
The invention provides a preparation method of a microneedle patch for quickly and efficiently relieving itching caused by mosquito bites, aiming at the problems of the existing product for relieving itching caused by mosquito bites and the requirements for quickly and efficiently relieving itching. The invention not only can quickly relieve itching and diminish inflammation, but also can accelerate the repair and the water replenishing of tissues, and the production convenience provides a new feasible scheme for the large-scale production of the soluble microneedle anti-itching microneedle patch.
In order to solve the technical problems and meet the technical requirements, the invention adopts the following technical scheme:
(1) preparing the itching relieving essence: adding PVA into a proper amount of purified water, heating to 95 ℃, stirring at a high speed until the PVA is fully dissolved, cooling to 50 ℃, respectively adding polyvinylpyrrolidone, continuously stirring until the polyvinylpyrrolidone is dissolved, cooling to room temperature, adding absolute ethyl alcohol and tea tree oil, and preparing into itching relieving essence, namely solution A;
(2) preparing basic antibacterial and anti-inflammatory essence: adding polyvinyl alcohol into a proper amount of purified water, heating to 95 ℃, stirring at a high speed until the polyvinyl alcohol is completely dissolved, standing and cooling to room temperature, adding absolute ethyl alcohol and tea tree oil, continuously stirring at room temperature until the solution is uniformly mixed, and preparing basic antibacterial and anti-inflammatory essence which is called solution B;
(3) preparation of soluble microneedles: and (3) injecting 1ml of the solution A into a PDMS microneedle mould, repeatedly vacuumizing for three times, then drying for 5-6 h, then taking 1.5ml of the solution B, scraping, drying for 10-12 h, and demoulding. And sticking the TPU medical adhesive plaster on the microneedle backing to prepare the itching relieving microneedle patch.
Preferably, in the preparation of the soluble microneedle, the vacuum degree is 0.08-0.1 Mpa, and the drying temperature is 35-45 ℃; preferably, the length of the micro-needle is 100-500 mu m, the distance between the micro-needles is 500-1000 mu m, the number of the micro-needle arrays is 5 multiplied by 5 mm or 8 multiplied by 8 mm or 10 multiplied by 10 mm or 20 multiplied by 20 mm, the diameter of the bottom of the conical needle point is 250-300 mu m, and the side length of the square at the bottom of the rectangular pyramid needle point is 200-400 mu m.
The invention has the following beneficial effects:
1. physical transdermal effect of the soluble microneedle, and the soluble microneedle is minimally invasive and painless. The tea tree oil in the microneedle can rapidly permeate through the skin, so that the tea tree oil can eliminate and decompose mosquito poison from the root, thereby achieving the purpose of relieving itching;
2. the itching relieving microneedle patch combines an external itching relieving mode of a traditional itching relieving product, and tea tree oil is dissolved in microneedles and microneedle backing through a painless minimally invasive physical transdermal technology, so that the inside and outside of the skin can relieve itching, and the itching relieving process becomes efficient and simple. The invention is the soluble microneedle, so the invention has no irreversible damage to human body and is green and environment-friendly.
The specific embodiment mode is as follows:
the technical solution of the present invention will be further described with reference to specific examples. It is to be understood that the following examples are only illustrative and explanatory of the present invention and should not be construed as limiting the scope of the present invention. All the techniques, principles and ideas based on the above-mentioned contents of the present invention are covered within the scope of the present invention; the starting materials and reagents used in the following examples are, unless otherwise specified, commercially available products or may be prepared by known methods.
Example 1
A preparation method of a microneedle patch for quickly and efficiently relieving itching caused by mosquito bites comprises the following steps:
(1) preparing the itching relieving essence: adding PVA into a proper amount of purified water, heating to 95 ℃, stirring at a high speed until the PVA is fully dissolved, cooling to 50 ℃, respectively adding polyvinylpyrrolidone, continuously stirring until the polyvinylpyrrolidone is dissolved, cooling to room temperature, adding absolute ethyl alcohol and tea tree oil, and preparing into itching relieving essence, namely solution A;
(2) preparing basic antibacterial and anti-inflammatory essence: adding polyvinyl alcohol into a proper amount of purified water, heating to 95 ℃, stirring at a high speed until the polyvinyl alcohol is completely dissolved, standing and cooling to room temperature, adding absolute ethyl alcohol and tea tree oil, continuously stirring at room temperature until the solution is uniformly mixed, and preparing basic antibacterial and anti-inflammatory essence which is called solution B;
(3) preparation of soluble microneedles: and (3) injecting 1ml of the solution A into a PDMS microneedle mould, repeatedly vacuumizing for three times, then drying for 5-6 h, then taking 1.5ml of the solution B, scraping, drying for 10-12 h, and demoulding. Sticking the TPU medical adhesive plaster on a microneedle backing to prepare an itching relieving microneedle patch;
in the step (3), in the preparation of the soluble microneedle, the vacuum degree is 0.1Mpa, the drying temperature is 35 ℃, the length of the microneedle is 300 microns, the distance between the microneedles is 1000 microns, the number of the microneedle arrays is 10 multiplied by 10 mm, and the diameter of the bottom of the conical needlepoint is 250 microns.
Example 2
The experimental method is the same as that of example 1, the soluble microneedle preparation mold and the environmental parameters in the step (3) are different, the vacuum degree is 0.1Mpa, the drying temperature is 40 ℃, the length of the microneedle needles is 380 μm, the distance between the microneedles is 600 μm, the number of the microneedle arrays is 10 × 10 mm, and the diameter of the bottom of the conical needlepoint is 300 μm.
Example 3
The experimental method is the same as that of example 1, the soluble microneedle preparation mold and the environmental parameters in the step (3) are different, the vacuum degree is 0.08 Mpa, the drying temperature is 35 ℃, the length of the microneedle is 380 μm, the distance between the microneedles is 600 μm, the number of the microneedle arrays is 10 × 10 mm, and the diameter of the bottom of the conical needlepoint is 300 μm.
Example 4
The experimental method is the same as that of example 1, the soluble microneedle preparation mold and the environmental parameters in the step (3) are different, the vacuum degree is 0.08 Mpa, the drying temperature is 40 ℃, the length of the microneedle is 450 micrometers, the distance between the microneedles is 1000 micrometers, the number of the microneedle arrays is 10 x 10 mm, and the diameter of the bottom of the conical needlepoint is 280 micrometers.
Example 5
The experimental method is the same as that of example 1, the soluble microneedle preparation mold and the environmental parameters in the step (3) are different, the vacuum degree is 0.09 Mpa, the drying temperature is 38 ℃, the length of the microneedle needles is 350 μm, the distance between the microneedles is 500 μm, the number of the microneedle arrays is 20 × 20 mm, and the diameter of the bottom of the conical needlepoint is 300 μm.
Example 6
The experimental method is the same as that of example 1, the soluble microneedle preparation mold and the environmental parameters in the step (3) are different, the vacuum degree is 0.1Mpa, the drying temperature is 40 ℃, the length of the microneedle is 380 μm, the distance between the microneedles is 500 μm, the number of the microneedle arrays is 20 × 20 mm, and the side length of the square at the bottom of the rectangular pyramid needlepoint is 300 μm.
Example 7
The experimental method is the same as that of example 1, the soluble microneedle preparation mold and the environmental parameters in the step (3) are different, the vacuum degree is 0.09 Mpa, the drying temperature is 38 ℃, the length of the microneedle is 500 μm, the distance between the microneedles is 500 μm, the number of the microneedle arrays is 20 × 20 mm, and the side length of the square at the bottom of the rectangular pyramid needlepoint is 280 μm.
Claims (10)
1. The preparation method of the rapid and efficient itching relieving microneedle patch for mosquito bites is characterized in that the itching relieving microneedle patch is prepared by adopting a microneedle process and comprises a microneedle point and a microneedle backing substrate layer, wherein the microneedle point contains effective itching relieving essence, and the microneedle backing substrate layer is a basic antibacterial and anti-inflammatory essence film and a TPU medical adhesive tape.
2. The microneedle patch for rapidly and efficiently relieving itching caused by mosquito bites according to claim 1, wherein the effective itching relieving essence contains the following components: PVA, tea tree oil, polyvinyl pyrrolidone, absolute ethyl alcohol and purified water.
3. The microneedle patch for rapidly and efficiently relieving itching caused by mosquito bites according to claim 1, wherein the basic antibacterial and anti-inflammatory essence film contains the following components: PVA, tea tree oil, absolute ethyl alcohol and purified water.
4. The rapid and efficient itching relieving microneedle patch for mosquito bites according to claim 2, wherein the effective itching relieving essence contains the following components in parts by weight: 2-4 parts of PVA, 10-15 parts of tea tree oil, 0.3-13 parts of polyvinylpyrrolidone, 22-29 parts of absolute ethyl alcohol and 45-58 parts of purified water.
5. The microneedle patch for rapidly and efficiently relieving itching caused by mosquito bites according to claim 2, wherein the basic antibacterial and anti-inflammatory essence film comprises the following components in parts by weight: 10-20 parts of PVA, 5-10 parts of tea tree oil, 33-44 parts of absolute ethyl alcohol and 33-44 parts of purified water.
6. The rapid and efficient itching relieving microneedle patch for mosquito bites according to claims 2 to 5, wherein the average molecular weight of the polyvinylpyrrolidone is 500000 to 1300000.
7. The preparation method of the rapid and efficient itching-relieving microneedle patch for mosquito bites according to any one of claims 1 to 6, characterized by comprising the following steps:
(1) preparing the itching relieving essence: adding PVA into a proper amount of purified water, heating to 95 ℃, stirring at a high speed until the PVA is fully dissolved, cooling to 50 ℃, respectively adding polyvinylpyrrolidone, continuously stirring until the polyvinylpyrrolidone is dissolved, cooling to room temperature, adding absolute ethyl alcohol and tea tree oil, and preparing into itching relieving essence, namely solution A;
(2) preparing basic antibacterial and anti-inflammatory essence: adding polyvinyl alcohol into a proper amount of purified water, heating to 95 ℃, stirring at a high speed until the polyvinyl alcohol is completely dissolved, standing and cooling to room temperature, adding absolute ethyl alcohol and tea tree oil, continuously stirring at room temperature until the solution is uniformly mixed, and preparing basic antibacterial and anti-inflammatory essence which is called solution B;
(3) preparation of soluble microneedles: injecting 1ml of the solution A into a PDMS microneedle mould, repeatedly vacuumizing for three times, then drying for 5-6 h, then taking 1.5ml of the solution B, scraping, drying for 10-12 h, and demoulding; and sticking the TPU medical adhesive plaster on the microneedle backing to prepare the itching relieving microneedle patch.
8. The method for preparing an antipruritic microneedle patch according to claim 7, wherein the degree of vacuum of the soluble microneedle is 0.06-0.1 Mpa, and the drying temperature is 30-50 ℃.
9. The method for preparing an antipruritic microneedle patch according to claim 7, wherein the microneedles are in the shape of a cone or a pyramid.
10. The preparation method of the itching relieving microneedle patch according to claim 7, wherein the length of the microneedle is 100-500 μm, the distance between the microneedles is 400-1000 μm, the number of the microneedle arrays is 5 x 5 mm or 8 x 8 mm or 10 x 10 mm or 20 x 20 mm, the diameter of the bottom of the conical needlepoint is 250-300 μm, and the side length of the square at the bottom of the rectangular pyramid needlepoint is 200-400 μm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110531744.6A CN113274372A (en) | 2021-05-17 | 2021-05-17 | Preparation method of microneedle patch for quickly and efficiently relieving itching due to mosquito bites |
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| CN202110531744.6A CN113274372A (en) | 2021-05-17 | 2021-05-17 | Preparation method of microneedle patch for quickly and efficiently relieving itching due to mosquito bites |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679658A (en) * | 2021-09-29 | 2021-11-23 | 浙江瑞瞳生物科技有限公司 | Soluble microneedle patch for itching-relieving and anti-allergic treatment of skin and preparation method thereof |
Citations (3)
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| KR20170046044A (en) * | 2015-10-20 | 2017-04-28 | 주식회사 엘지생활건강 | Soluble microneedle patch containing anti-itching drug in atopic dermatitis |
| CN108404201A (en) * | 2018-04-27 | 2018-08-17 | 泰州市榕兴医疗用品股份有限公司 | A kind of anti-bacterial, anti-itching dressing and preparation method thereof containing tea oil |
| JP2018143758A (en) * | 2017-03-03 | 2018-09-20 | Ｎｉｓｓｈａ株式会社 | Antipruritic patch |
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- 2021-05-17 CN CN202110531744.6A patent/CN113274372A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20170046044A (en) * | 2015-10-20 | 2017-04-28 | 주식회사 엘지생활건강 | Soluble microneedle patch containing anti-itching drug in atopic dermatitis |
| JP2018143758A (en) * | 2017-03-03 | 2018-09-20 | Ｎｉｓｓｈａ株式会社 | Antipruritic patch |
| CN108404201A (en) * | 2018-04-27 | 2018-08-17 | 泰州市榕兴医疗用品股份有限公司 | A kind of anti-bacterial, anti-itching dressing and preparation method thereof containing tea oil |
Non-Patent Citations (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679658A (en) * | 2021-09-29 | 2021-11-23 | 浙江瑞瞳生物科技有限公司 | Soluble microneedle patch for itching-relieving and anti-allergic treatment of skin and preparation method thereof |
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Application publication date: 20210820 |