CN113272315A - 一类类固醇化合物及其用途 - Google Patents
一类类固醇化合物及其用途 Download PDFInfo
- Publication number
- CN113272315A CN113272315A CN201980085667.7A CN201980085667A CN113272315A CN 113272315 A CN113272315 A CN 113272315A CN 201980085667 A CN201980085667 A CN 201980085667A CN 113272315 A CN113272315 A CN 113272315A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- alkenyl
- alkynyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明提供式(I)，(II)，(III)和(IV)化合物，其立体异构体、互变异构体或药学上可接受的盐，本发明公开了该类化合物的制备方法和所述化合物在治疗疾病中的用途，如各种神经系统疾病，
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018115946743 | 2018-12-26 | ||
| CN201811594674 | 2018-12-26 | ||
| CN201910947023 | 2019-10-07 | ||
| CN2019109470236 | 2019-10-07 | ||
| PCT/CN2019/128092 WO2020135454A1 (zh) | 2018-12-26 | 2019-12-24 | 一类类固醇化合物及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113272315A true CN113272315A (zh) | 2021-08-17 |
| CN113272315B CN113272315B (zh) | 2023-08-08 |
Family
ID=71128666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980085667.7A Active CN113272315B (zh) | 2018-12-26 | 2019-12-24 | 一类类固醇化合物及其用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113272315B (zh) |
| WO (1) | WO2020135454A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019140272A1 (en) | 2018-01-12 | 2019-07-18 | Sage Therapeutics, Inc. | Aza-, oxa and thia-pregnan-20-one-3.alpha.-ol compounds for use in treating cns disorders |
| JP2023518411A (ja) * | 2020-03-18 | 2023-05-01 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド及びその使用方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018013615A1 (en) * | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C7, c12, and c16 substituted neuroactive steroids and their methods of use |
| WO2018195186A1 (en) * | 2017-04-18 | 2018-10-25 | Marinus Pharmaceuticals, Inc | Sustained release injectable neurosteroid formulations |
| CN109503694A (zh) * | 2018-11-21 | 2019-03-22 | 苏州闻天医药科技有限公司 | 一种新型gabaa受体调节剂及其用途 |
| WO2019154247A1 (zh) * | 2018-02-11 | 2019-08-15 | 江苏豪森药业集团有限公司 | 甾族类衍生物调节剂、其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111565724A (zh) * | 2017-11-10 | 2020-08-21 | 马瑞纳斯制药公司 | 加奈索酮用于治疗遗传性癫痫病 |
| US20210139530A1 (en) * | 2018-02-11 | 2021-05-13 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
-
2019
- 2019-12-24 WO PCT/CN2019/128092 patent/WO2020135454A1/zh active Application Filing
- 2019-12-24 CN CN201980085667.7A patent/CN113272315B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018013615A1 (en) * | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C7, c12, and c16 substituted neuroactive steroids and their methods of use |
| WO2018195186A1 (en) * | 2017-04-18 | 2018-10-25 | Marinus Pharmaceuticals, Inc | Sustained release injectable neurosteroid formulations |
| WO2019154247A1 (zh) * | 2018-02-11 | 2019-08-15 | 江苏豪森药业集团有限公司 | 甾族类衍生物调节剂、其制备方法和应用 |
| CN109503694A (zh) * | 2018-11-21 | 2019-03-22 | 苏州闻天医药科技有限公司 | 一种新型gabaa受体调节剂及其用途 |
Non-Patent Citations (1)
| Title |
|---|
| EDWARDS ET AL: ""Mannich Bases of 4-Phenyl-3-buten-2-one: A New Class of Antiherpes Agent"", 《JOURNAL OF MEDICINAL CHEMISTRY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113272315B (zh) | 2023-08-08 |
| WO2020135454A1 (zh) | 2020-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |