CN113267556B - Mobile drug detection system and method - Google Patents
Mobile drug detection system and method Download PDFInfo
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- CN113267556B CN113267556B CN202110815090.XA CN202110815090A CN113267556B CN 113267556 B CN113267556 B CN 113267556B CN 202110815090 A CN202110815090 A CN 202110815090A CN 113267556 B CN113267556 B CN 113267556B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B62—LAND VEHICLES FOR TRAVELLING OTHERWISE THAN ON RAILS
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Abstract
The invention provides a mobile drug detection system and a mobile drug detection method, wherein the mobile drug detection system comprises a detection vehicle and a mass spectrometer, and the mass spectrometer comprises an ion sampling device and an ion funnel; the interior of the detection vehicle is divided into a sampling area, a pretreatment area and a detection area; a stool is arranged in the sampling area, and the mass spectrometer is arranged in the detection area; the ion sampling device includes: a plurality of capillary needles are used for sampling and sample ionization; one side of the bearing piece facing the inlet end of the ion funnel is a convex curved surface, and the capillary needle is fixed on the bearing piece and extends into the ion funnel; the distance between the capillary needles becomes larger along the direction from the bearing part to the ion funnel; the imaging module is fixed on one side of the bearing piece facing the ion funnel and used for obtaining an image of the inner side of the ion funnel; the adjusting device is used for adjusting the position of the bearing piece, so that the included angle between any capillary needle and the horizontal plane containing the central axis of the ion funnel is adjusted. The invention has the advantages of rapid detection, high flux and the like.
Description
Technical Field
The present invention relates to drug detection, and more particularly, to a mobile drug detection system and method.
Background
Along with the improvement of the living standard of people, the drug-taking population shows an increasing trend, the harm to the society is larger and larger, and the timely identification of whether the person takes the drug or not is very important for the drug-prohibiting work.
The current drug detection mode is as follows: in a detection laboratory, hair or urine is collected, and after pretreatment and analysis, whether to take poison, the name of a drug and the time for taking poison are obtained. The main disadvantages of this detection method are:
the detection efficiency is poor, and the consumed time is long; direct testing cannot be performed on site and personnel must be brought to the testing laboratory.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a mobile drug detection system.
The purpose of the invention is realized by the following technical scheme:
the mobile drug detection system comprises a detection vehicle and a mass spectrometer, wherein the mass spectrometer comprises an ion sampling device and an ion funnel, and the ion funnel comprises a plurality of electrodes with through holes; the interior of the detection vehicle is divided into a sampling area, a pretreatment area and a detection area; a stool is arranged in the sampling area, and the mass spectrometer is arranged in the detection area; the ion sampling device comprises:
a plurality of capillary needles for sampling and ionization of a sample;
the side, facing the inlet end of the ion funnel, of the bearing piece is a convex curved surface, and the capillary needle is fixed on the bearing piece and extends into the ion funnel; the distance between the capillary needles becomes larger along the direction from the bearing part to the ion funnel;
the imaging module is fixed on one side of the bearing piece facing the ion funnel and used for obtaining an image of the inner side of the ion funnel;
and the adjusting device is used for adjusting the position of the bearing piece so as to adjust the included angle between any capillary needle and the horizontal plane containing the central axis of the ion funnel.
Another object of the present invention is to provide a mobile drug testing method using the mobile drug testing system, which is achieved by the following technical solutions:
the mobile drug detection method comprises a sampling stage, a pretreatment stage and a detection stage; the detection stage comprises ion sampling, and the ion sampling comprises the following steps:
(A1) obtaining an image of the inner side of the ion funnel by using an imaging module so as to obtain a pollution map of the ion funnel;
(A2) according to the pollution map, obtaining an ion admission area and an ion non-admission area;
(A3) obtaining a set position of the capillary needle corresponding to the sample to be detected, so that ions emitted from the capillary needle enter an ion admission area;
the adjusting device, the bearing piece and the ion funnel are sequentially arranged, and one side of the bearing piece facing the inlet end of the ion funnel is a convex curved surface; the capillary needles are fixed on the bearing piece and extend into the ion funnel, and the distance between the capillary needles is increased along the direction from the bearing piece to the ion funnel; the imaging module is arranged on the convex curved surface;
(A4) adjusting the capillary needle to the set position by using an adjusting device;
(A5) the sample on the capillary needle is ionized and ions entering the ion funnel are allowed to enter the region.
Compared with the prior art, the invention has the beneficial effects that:
1. the device has the function of field detection;
by means of the mobile detection vehicle, the detection has maneuverability, and all-weather application detection requirements such as sudden accidents, sudden impact virus removal and the like are met;
2. the sensitivity is high, and the detection flux is large;
in the detection of each sample, an ion funnel pollution graph needs to be obtained firstly, so that the position of a capillary needle when the sample to be detected is planned, ions are prevented from entering an ion non-allowed entering area (a seriously polluted area), the ions are ensured to enter the ion allowed entering area, and the detection sensitivity is ensured;
the length of the capillary needle between the curved surface and the ion funnel meets the condition, so that the capillary needle cannot touch the ion funnel in the adjusting process, and the working stability of the capillary needle is ensured;
a plurality of capillary needles are adopted to correspond to different samples to be detected, namely a plurality of detection samples are simultaneously placed on the bearing piece, so that the continuous detection of the plurality of samples to be detected is realized, and the detection flux is large;
3. the detection efficiency is high;
in the assembly of the scissors in the pretreatment stage, the fixing unit disclosed by the invention is utilized to realize the rapid installation and disassembly of the scissors, so that the overall detection efficiency is improved;
drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only for illustrating the technical solutions of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a schematic diagram of a mobile drug testing system according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of an ion sampling apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a truncating means according to an embodiment of the invention;
FIG. 4 is a schematic diagram of a partial structure of a truncating device according to an embodiment of the invention
Fig. 5 is a schematic structural view of a rotary arm and a driving unit according to an embodiment of the present invention;
FIG. 6 is a schematic structural diagram of a fixing unit according to an embodiment of the present invention;
FIG. 7 is a schematic view of a scissors according to an embodiment of the present invention;
FIG. 8 is a schematic flow chart illustrating a mobile drug testing method according to an embodiment of the present invention;
fig. 9 is a schematic illustration of contamination of an ion funnel according to an embodiment of the present invention.
Detailed Description
Fig. 1-9 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and use the invention. Some conventional aspects have been simplified or omitted for the purpose of explaining the technical solution of the present invention. Those skilled in the art will appreciate that variations or substitutions from these embodiments will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1 is a schematic diagram illustrating a mobile drug detection system according to embodiment 1 of the present invention, and as shown in fig. 1, the mobile drug detection system includes:
an inspection vehicle 701, such as a van; the detection vehicle 701 is divided into a sampling area 702, a pretreatment area 703 and a detection area 704; a stool 801 is arranged in the sampling area 702, a mass spectrometer 805 comprises an ion sampling device 8051 and an ion funnel, the ion funnel comprises a plurality of electrodes 31 with through holes, and the mass spectrometer 805 is arranged in the detection area 704;
fig. 2 schematically shows a structure diagram of an ion implantation device 8051 according to an embodiment of the present invention, and as shown in fig. 2, the ion implantation device 8051 includes:
a plurality of capillary needles 11, the capillary needles 11 being used for sampling and ionization of a sample;
the bearing part 21, one side of the bearing part 21 facing the inlet end of the ion funnel is a convex curved surface, and the capillary needle 11 is fixed on the bearing part 21 and extends into the ion funnel; the distance between the capillary needles 11 in the direction from the carrier 21 to the ion funnel becomes larger;
an imaging module, such as a photosensor, fixed to the side of the carrier 21 facing the ion funnel for obtaining an image of the inside of the ion funnel;
an adjusting device for adjusting the position of the carrier 21, thereby adjusting the angle between any capillary 11 and the horizontal plane containing the central axis of the ion funnel.
In order to ensure that the capillary needles 11 extending into the ion funnel do not touch the ion funnel and that the ions enter the ion funnel directly, further, the length L of any capillary needle 11 between the outwardly convex curved surface and the ion funneliSatisfies the following conditions:
In order to obtain the length of the capillary needle 11 between the carrier 21 and the ion funnel, further, the length LiAlso satisfies:
If the test sample is hair, a cutting device 803, a cleaning unit 802 and a grinding unit 804 are arranged in the pretreatment region 703;
fig. 3 schematically shows a block diagram of a cutting apparatus 803 according to embodiment 1 of the present invention, and as shown in fig. 3, the cutting apparatus 803 includes:
a pair of scissors and a bracket, wherein the scissors comprise a rotating shaft 103, a first operating handle 101 and a second operating handle 102, and the second operating handle 102 rotates around the rotating shaft 103;
a fixing unit 601, the fixing unit 601 being used for fixing the first operation handle 101;
a rotating shaft 302, wherein the rotating shaft 302 is fixed on the bracket;
a rotating arm 301, as shown in fig. 4-5, said rotating arm 301 having a first aperture 303 and a second aperture 304;
a first upright 201 and a second upright 402, said first upright 201 being fixed to said second operating handle 102 and being allowed to slide inside said first hole 303; the second upright 402 is fixed to the drive unit and is allowed to slide in the second hole 304;
and a driving unit, such as a linear running mechanism or a rotating mechanism, for driving the second upright post 402 to translate or rotate, so that the rotating arm 301 rotates around the rotating shaft 302 in the forward and reverse directions, thereby driving the first upright post 201 to slide in the first hole 303 of the rotating arm 301 and rotate around the rotating shaft 302, further driving the second operating handle 102 to rotate, and realizing the cutting function of the scissors.
In order to automatically drive the second operation handle 102 to rotate forwardly and reversely about the rotation shaft 103, further, as shown in fig. 5, the driving unit includes:
a motor 401 and a rotary plate 403, wherein the motor 401 drives the rotary plate 403 to rotate, and the second upright 402 is arranged at the non-center of the rotary plate 403.
To facilitate the mounting and dismounting of the scissors, further, as shown in fig. 6 to 7, the fixing unit 601 includes:
a base plate 602, wherein the base plate 602 fixes at least two cylinders, such as a first cylinder 604 and a second cylinder 605, and the first cylinder 604 and the second cylinder 605 allow a through hole passing through the first operating handle 101;
a shutter 607 and a guide 606, the shutter 607 moving forward and backward along the guide 606;
the shielding member 607 shields at least a part of the cylinders, such as the first cylinder 604 and the second cylinder 605, by the elastic force of the elastic member 608.
To fix the scissors (first operation handle 101), further, as shown in fig. 6, the bottom plate 602 has a groove 603 allowing the first operation handle 101 to be caught.
In order to reduce the volume of the intercepting means 803, further, as shown in fig. 5, the rotating arm 301 comprises a first portion and a second portion, the included angle between the first portion and the second portion is an obtuse angle, the first hole 303 is disposed on the first portion, and the second hole 304 is disposed on the second portion; the rotation shaft 302 passes through a connection portion between the first portion and the second portion.
Fig. 8 is a flow chart schematically illustrating a mobile drug testing method according to an embodiment of the present invention, and as shown in fig. 8, the mobile drug testing method includes a sampling phase, a preprocessing phase, and a testing phase; the detection stage comprises ion sampling, and the ion sampling comprises the following steps:
(A1) obtaining an image of the inner side of the ion funnel by using an imaging module so as to obtain a pollution map of the ion funnel, wherein the darker the color is, the more serious the pollution is;
(A2) obtaining an ion allowable entry region and an ion unallowable entry region according to the contamination map, as shown in fig. 9, a light color region is an ion allowable entry region, and a black color region is an ion unallowable entry region;
(A3) obtaining a set position of the capillary needle 11 corresponding to the sample to be measured, so that ions emitted from the capillary needle 11 enter an ion admission area;
the adjusting device, the bearing piece 21 and the ion funnel are sequentially arranged, and one side of the bearing piece 21 facing the inlet end of the ion funnel is a convex curved surface; a plurality of capillary needles 11 are fixed on the bearing member 21 and extend into the ion funnel, and the distance between the capillary needles 11 is increased along the direction from the bearing member 21 to the ion funnel; the imaging module is arranged on the convex curved surface;
(A4) adjusting the capillary needle 11 to the set position by an adjusting device;
(A5) the sample on the capillary needle 11 is ionized and ions entering the ion funnel are allowed to enter the region.
In order to ensure that the capillary needles 11 extending into the ion funnel do not touch the ion funnel and that the ions enter the ion funnel directly, further, the length L of any capillary needle 11 between the outwardly convex curved surface and the ion funneliSatisfies the following conditions:
In order to obtain the length of the capillary needle 11 between the carrier 21 and the ion funnel, further, the length LiAlso satisfies:
If the sample to be tested is hair, scissors are required to cut off the hair, and in order to improve the efficiency of assembling and disassembling (the process is opposite to the assembling) of the scissors, the pretreatment stage further comprises the following steps:
(B1) the scissors comprise a first operating handle 101, a second operating handle 102 and a rotating shaft 103, wherein the rotating shaft 103 is fixed on the first operating handle 101, and the first operating handle 101 is fixed in a way that:
as shown in fig. 6, when an external force is applied to the shutter 607, the shutter 607 moves in the forward direction on the guide 606, and the elastic member 608 is compressed;
the cylinder shielded by the shielding member 607 is exposed, and the cylinder (such as the first cylinder 604 and the second cylinder 605) on the bottom plate 602 passes through the through hole on the first operating handle 101;
when the external force is removed, the shielding member 607 moves reversely under the action of the elastic member 608 to shield the cylinders (such as the first cylinder 604 and the second cylinder 605), as shown in fig. 7, the part of the first operating handle 101 is located between the bottom plate 602 and the shielding member 607, so as to prevent the first operating handle 101 from moving up and down;
(B2) the driving unit drives the rotating arm 301 to rotate forwards around the rotating shaft 302, the rotating arm 301 drives the first upright post 201 to rotate backwards around the rotating shaft 103 of the scissors, and the first upright post 201 drives the second operating handle 102 of the scissors to rotate backwards, so that the hair is cut off;
after the rotating arm 301 rotates forward to the maximum angle, the rotating arm 301 automatically rotates in the reverse direction, the rotating arm 301 drives the first upright post 201 to rotate forward around the rotating shaft 103 of the scissors, and the first upright post 201 drives the second operating handle 102 of the scissors to rotate forward.
In order to automatically drive the second operation handle 102 to rotate around the rotation shaft 103 in the forward and reverse directions, further, the rotation arm 301 is driven in the following manner:
the motor 401 drives the turntable 403 to rotate, and the second upright post 402 arranged at the non-center of the turntable 403 slides in the second hole 304 of the rotating arm 301 to push the rotating arm 301 to rotate in the positive direction and the direction;
the rotating arm 301 pushes the first upright 201 in the second hole 304 on it to rotate around the rotating shaft 103 of the scissors, thereby pushing the second operating handle 102 to rotate, and the first upright 201 is fixed on the second operating handle 102.
Example 2:
an application example of the mobile drug detection system and method according to embodiment 1 of the present invention is described.
In the present application example, as shown in fig. 2, 6 capillary needles 11 were used for sampling the hair sample after grinding and hydrolysis, and ionization of the sample, respectively; the ion funnel comprises a plurality of electrodes 31 with through holes, the diameter of the through holes of the plurality of electrodes 31 is reduced along the ion transmission direction, and the inner walls of the plurality of electrodes 31 enclose a truncated cone shape; the bearing piece 21 is arranged on the adjusting device, one side of the bearing piece 21 facing the inlet end of the ion funnel is a convex curved surface, such as a spherical surface, and the 6 capillary needles 11 are fixed on the bearing piece 21 and extend into the ion funnel; the distance between the capillary needles 11 in the direction from the carrier 21 to the ion funnel becomes larger; the adjusting device is used for adjusting the position of the bearing part 21 in three dimensions, so that the included angle between any capillary needle 11 and the horizontal plane containing the central axis of the ion funnel is adjusted, and ions emitted from the capillary needle 11 enter an ion-funnel-inside ion-admission area; the imaging module adopts a photoelectric sensor, and is fixed on one side of the bearing piece 21 facing the ion funnel and used for obtaining an image of the inner side of the ion funnel; adjusting devices and their working methods are the prior art in this field, and can be found in patents CN110285778A, CN 110286011A;
the length L of any capillary needle 11 between the curved surface and the ion funneliSatisfies the following conditions:
d is the distance between the center of the curved surface and the inlet end of the ion funnel, 2mm in this embodiment, and θyiIs the angle between the ith capillary needle 11 and the horizontal plane containing the central axis of the ion funnel; r1Is the radius of the carrier 21, which in this embodiment is 350mm, R2Is the outer diameter of the ion funnel, 20mm in this example, i =1, 2 … N, N being the number of capillary needles 11, θymaxIs theta in the adjusting processyiNo greater than 5 degrees; can obtain 2mm<Li<148mm；
As shown in fig. 1, a cutoff device 803, a cleaning unit 802 and a grinding unit 804 are provided in the pretreatment zone 703;
as shown in fig. 3, the cut-off unit 803 is pistol-shaped; the first operating handle 101 is fixed on the fixing unit 601, and the second operating handle 102 rotates around the rotating shaft 103;
as shown in fig. 4-5, the rotating arm 301 comprises a first portion and a second portion, wherein an included angle between the first portion and the second portion is an obtuse angle; the rotating shaft 302 passes through the connection between the first part and the second part; a first hole 303 is provided on the first portion and a second hole 304 is provided on the second portion; the first upright 201 is fixed to said second operating handle 102 and is allowed to slide in said first hole 303; a second upright 402 is fixed to the drive unit and is allowed to slide in said second hole 304;
as shown in fig. 6, the driving unit includes a motor 401 and a rotating disc 403, the motor 401 drives the rotating disc 403 to rotate, and the second upright 402 is disposed at a non-center of the rotating disc 403; battery 501 provides power to motor 401;
as shown in fig. 6 to 7, the fixing unit 601 includes a bottom plate 602, a shutter 607, a guide 606, and an elastic member 608, the bottom plate 602 has a groove 603 allowing the first operation handle 101 to be caught therein and fixes a first cylinder 604 and a second cylinder 605, the first cylinder 604 and the second cylinder 605 have through holes allowing the first operation handle 101 to pass therethrough; the shutter 607 moves along the guide groove of the guide 606; the elastic member 608 is a spring and is disposed in the guide groove, and the shielding member 607 shields the first cylinder 604 and the second cylinder 605 by the elastic force of the elastic member 608.
The mobile drug detection method of the embodiment of the present invention, that is, the working method of the drug detection system of the embodiment, includes:
in the sampling stage, the detection vehicle 701 moves to a detection site, the detected person enters a sampling area 702 of the detection vehicle 701 and sits on a stool 801, and the detection person cuts the hair of the detected person;
in the pretreatment stage, the hair is firstly cleaned, and the specific mode is as follows:
washing hair for the first time by using a deionized water solution containing a surfactant, wherein the volume percentage of the surfactant is 0.5-5%, and the surfactant at least comprises sodium dodecyl sulfate or sodium dodecyl benzene sulfonate;
and then carrying out second washing on the hair subjected to the first washing by using an organic solvent, wherein the organic solvent is one or more of the following organic agents: acetone, methanol, ethanol, dichloromethane, acetonitrile or ethyl acetate;
then, repeatedly cutting the hair to make the hair shorter in such a manner that,
the scissors are installed in a specific mode that:
as shown in fig. 6, when an external force is applied to the shutter 607, the shutter 607 moves forward in the guide groove of the guide member 606, and the elastic member 608 is compressed;
the first cylinder 604 and the second cylinder 605 shielded by the shielding piece 607 are exposed, the first cylinder 604 and the second cylinder 605 on the bottom plate 602 pass through the through hole on the first operating handle 101, and the first operating handle 101 is clamped in the groove 603 of the bottom plate 602;
when the external force is removed, the shielding member 607 moves reversely by the elastic member 608 to shield the first cylinder 604 and the second cylinder 605, so as to prevent the first operation handle 101 from moving upward, as shown in fig. 6;
the first upright 201 on the second operating handle 102 is inserted downwards into the first hole 303 of the rotating arm 301;
the motor 401 drives the rotating disc 403 to rotate in a forward direction (e.g. counterclockwise), that is, drives the second upright post 402 in the second hole 304 to rotate in the forward direction, so as to push the rotating arm 301 to rotate in the forward direction (e.g. counterclockwise) around the rotating shaft 302, the rotating arm 301 drives the first upright post 201 in the first hole 303 to slide and rotate in a reverse direction (e.g. clockwise) around the rotating shaft 103 of the scissors, and the first upright post 201 drives the second operating handle 102 of the scissors to rotate in the reverse direction (e.g. clockwise), so as to cut hair;
the rotating disc 403 still rotates in the forward direction (e.g. counterclockwise), and after the rotating arm 301 rotates in the forward direction to the maximum angle, it automatically rotates in the reverse direction (e.g. clockwise), i.e. drives the second upright post 402 in the second hole 304 to rotate in the reverse direction, thereby pushing the rotating arm 301 to rotate in the reverse direction (e.g. clockwise) around the rotating shaft 302, the rotating arm 301 drives the second upright post 402 in the second hole 304 to slide, the first upright post 201 drives the second operating handle 102 of the scissors to rotate in the forward direction
The forward rotation of the rotary disc 403 realizes the forward and reverse rotation of the second operating handle 102 around the rotating shaft 103, and realizes the function of automatically cutting off hair; obviously, the reverse rotation of the turntable 403 can also implement the above-mentioned automatic cut-off function;
then, the cut hair is ground in the following specific mode:
putting the cut hair into a grinding tube filled with 1-10 grinding beads; the hair amount is 15-35 mg, the grinding beads can be made of zirconia or stainless steel, and the grinding pipe can be made of stainless steel or a polymer material with certain strength;
adding 0.1-1 mL of grinding fluid, and grinding for 1-30 minutes in a grinding instrument at a frequency of 20-100 Hz. The grinding fluid is a mixture of one or more of the following solutions: water, methanol, ethanol, acetonitrile, acetone, propanol;
centrifuging at the rotating speed of 5000-15000 rpm for 1-10 minutes, and then sucking the supernatant to another centrifugal tube for detection;
dipping the supernatant of each sample to be detected by using each capillary needle 11 respectively, and fixing the capillary needle 11 on the bearing member 21;
in the detection stage, the mass spectrometry is used to detect the grinded hair, and the ion sample introduction device 8051 is used to introduce a sample to judge whether the detected person is toxic, and the ion sample introduction specifically comprises:
(A1) obtaining an image of the inner side of the ion funnel by using an imaging module so as to obtain a pollution map of the ion funnel, wherein the darker the color is, the more serious the pollution is;
(A2) obtaining an entrance-allowed region and an entrance-disallowed region of ions from the contamination map, as in fig. 9, the light-colored and colorless region is an ion-allowed entrance region, and the black region is an ion-disallowed entrance region;
(A3) obtaining a set position of the capillary needle 11 corresponding to the sample to be measured, so that ions emitted from the capillary needle 11 enter an entrance-permitting region;
(A4) three-dimensionally adjusting the position of the carrier 21 with an adjusting device, thereby adjusting the capillary needles 11 to the set position;
(A5) the sample on the capillary needle 11 is ionized, and the ions enter the admission area of the ion funnel;
in the detection method, when the scissors need to be disassembled, the specific mode is as follows:
as shown in fig. 6, when an external force is applied to the shutter 607, the shutter 607 moves forward in the guide groove of the guide member 606, and the elastic member 608 is compressed;
the first cylinder 604 and the second cylinder 605 shielded by the shielding member 607 are exposed, and the first operating handle 101 is moved upward, so that the first operating handle 101 is separated from the groove 603, and the first cylinder 604 and the second cylinder 605 are separated from the through hole;
when the external force is removed, the shielding member 607 moves reversely under the action of the elastic member 608 to shield the first cylinder 604 and the second cylinder 605.
Example 3:
an application example of the mobile drug detection system and method according to embodiment 1 of the present invention is different from embodiment 2 in that:
1. in the intercepting means 803, a linear guide is provided, and the angle between the extending direction of the linear guide and the extending direction of the second hole 304 is not zero; the second upright 402 is arranged on the linear guide rail and moves linearly in the forward direction and the reverse direction along the linear guide rail;
the driving unit drives the second upright 402 to move linearly in forward and reverse directions on the linear guide rail by using a linear movement mechanism, so that the rotating arm 301 is driven to rotate around the rotating shaft 302.
2. Urine of a detected person is collected, the pre-treatment area 703 does not need to be cut off by the cutting-off device 803, the grinding unit 804 and the cleaning unit 802, and the pre-treatment stage does not need to be cut off, ground and cleaned.
Claims (9)
1. The mobile drug detection system comprises a detection vehicle and a mass spectrometer, wherein the mass spectrometer comprises an ion sampling device and an ion funnel, and the ion funnel comprises a plurality of electrodes with through holes; the device is characterized in that the interior of the detection vehicle is divided into a sampling area, a pretreatment area and a detection area; a stool is arranged in the sampling area, and the mass spectrometer is arranged in the detection area; the ion sampling device comprises:
a plurality of capillary needles for sampling and ionization of a sample;
the side, facing the inlet end of the ion funnel, of the bearing piece is a convex curved surface, and the capillary needle is fixed on the bearing piece and extends into the ion funnel; the distance between the capillary needles becomes larger along the direction from the bearing part to the ion funnel;
the imaging module is fixed on one side of the bearing piece facing the ion funnel and used for obtaining an image of the inner side of the ion funnel;
and the adjusting device is used for adjusting the position of the bearing piece according to the image so as to adjust an included angle between any capillary needle and a horizontal plane containing the central axis of the ion funnel.
2. The mobile drug testing system of claim 1, wherein the mobile drug testing system is further characterized in thatThe length L of the part of any capillary needle on one side of the curve facing the ion funneliSatisfies the following conditions:
3. The mobile drug testing system of claim 2, wherein the length L is greater than the length L of the mobile drug testing systemiAlso satisfies:
4. The mobile drug testing system of claim 1, wherein the position of the carrier is adjusted by:
obtaining an image of the inner side of the ion funnel by using an imaging module so as to obtain a pollution map of the ion funnel;
according to the pollution map, obtaining an ion admission area and an ion non-admission area;
the position of the carrier is adjusted so that ions exiting the capillary needle enter the ion admission area.
5. The mobile drug detection system of claim 1, wherein a cutting device, a cleaning unit and a grinding unit are disposed in the pretreatment region, the cutting device comprises a pair of scissors, a bracket and a fixing unit, the pair of scissors comprises a rotating shaft, a first operating handle and a second operating handle; the fixing unit includes:
the bottom plate is fixedly provided with at least two columns, and the columns are allowed to penetrate through the through holes of the first operating handle;
a shutter and a guide along which the shutter moves;
the shielding piece shields at least part of the cylinder under the elastic force of the elastic piece.
6. A mobile drug testing method using the mobile drug testing system of claim 1, wherein the mobile drug testing method comprises a sampling phase, a pre-treatment phase and a testing phase; the sampling stage is that the detection vehicle moves to a detection site to complete sampling; the method is characterized in that the detection stage comprises ion sample introduction, and the ion sample introduction comprises the following steps:
(A1) obtaining an image of the inner side of the ion funnel by using an imaging module so as to obtain a pollution map of the ion funnel;
(A2) according to the pollution map, obtaining an ion admission area and an ion non-admission area;
(A3) obtaining a set position of the capillary needle corresponding to the sample to be detected, so that ions emitted from the capillary needle enter an ion admission area;
(A4) adjusting the capillary needle to the set position by using an adjusting device;
(A5) the sample on the capillary needle is ionized and ions entering the ion funnel are allowed to enter the region.
7. The mobile drug testing method of claim 6, wherein the length L of the portion of any capillary needle on the side of the curved surface facing the ion funneliSatisfies the following conditions:
8. The mobile drug testing method of claim 7, wherein the length L is greater than the length L of the first and second electrodesiAlso satisfies:
9. The mobile drug testing method of claim 6, wherein the pre-processing stage comprises the steps of:
(B1) fixed scissors, the scissors includes first operation handle, second operation handle and pivot, the pivot is fixed on first operation handle, the fixed mode of first operation handle is:
applying external force to the shielding piece, enabling the shielding piece to move in the positive direction on the guide piece, and compressing an elastic piece connected with the shielding piece;
the cylinder shielded by the shielding piece is exposed, and the cylinder on the bottom plate passes through the through hole on the first operating handle;
the external force is removed, the shielding piece moves reversely under the action of the elastic piece to shield the cylinder, and part of the first operating handle is positioned between the bottom plate and the shielding piece;
(B2) the driving unit drives the rotating arm to rotate around the rotating shaft in the forward direction, the rotating arm drives the first upright post to rotate around the rotating shaft of the scissors in the reverse direction, and the first upright post drives the second operating handle of the scissors to rotate around the rotating shaft in the reverse direction, so that collected hair is cut off;
after the rotating arm positively rotates to the maximum angle, the rotating arm automatically rotates reversely, the rotating arm drives the first upright post to rotate positively, and the first upright post drives the second operating handle of the scissors to rotate positively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110815090.XA CN113267556B (en) | 2021-07-19 | 2021-07-19 | Mobile drug detection system and method |
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