CN113267434A - Cigarette smoke oral deposition simulation device and method - Google Patents
Cigarette smoke oral deposition simulation device and method Download PDFInfo
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- CN113267434A CN113267434A CN202110696265.XA CN202110696265A CN113267434A CN 113267434 A CN113267434 A CN 113267434A CN 202110696265 A CN202110696265 A CN 202110696265A CN 113267434 A CN113267434 A CN 113267434A
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- 239000000779 smoke Substances 0.000 title claims abstract description 115
- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 67
- 230000008021 deposition Effects 0.000 title claims abstract description 58
- 238000004088 simulation Methods 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 25
- 230000000391 smoking effect Effects 0.000 claims abstract description 35
- 210000000214 mouth Anatomy 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000120 Artificial Saliva Substances 0.000 claims abstract description 13
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003546 flue gas Substances 0.000 claims abstract description 11
- 230000009747 swallowing Effects 0.000 claims abstract description 4
- 239000011521 glass Substances 0.000 claims description 9
- 239000011229 interlayer Substances 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 7
- 230000006399 behavior Effects 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 5
- 238000011160 research Methods 0.000 claims description 5
- 238000005086 pumping Methods 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 abstract description 4
- 239000002245 particle Substances 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 3
- 210000002200 mouth mucosa Anatomy 0.000 abstract 1
- 238000000151 deposition Methods 0.000 description 41
- 238000013461 design Methods 0.000 description 5
- 150000001728 carbonyl compounds Chemical class 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 239000003517 fume Substances 0.000 description 3
- XPFVYQJUAUNWIW-UHFFFAOYSA-N furfuryl alcohol Chemical compound OCC1=CC=CO1 XPFVYQJUAUNWIW-UHFFFAOYSA-N 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- JHWFWLUAUPZUCP-UHFFFAOYSA-N 3-Ethyl-2-hydroxycyclopent-2-en-1-one Chemical compound CCC1=C(O)C(=O)CC1 JHWFWLUAUPZUCP-UHFFFAOYSA-N 0.000 description 2
- CHCCBPDEADMNCI-UHFFFAOYSA-N 3-Methyl-2-cyclopenten-1-one Chemical compound CC1=CC(=O)CC1 CHCCBPDEADMNCI-UHFFFAOYSA-N 0.000 description 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- 241000208125 Nicotiana Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- CFAKWWQIUFSQFU-UHFFFAOYSA-N 2-hydroxy-3-methylcyclopent-2-en-1-one Chemical compound CC1=C(O)C(=O)CC1 CFAKWWQIUFSQFU-UHFFFAOYSA-N 0.000 description 1
- -1 3, 4-dimethylcyclopentenol ketones Chemical class 0.000 description 1
- ZZEYQBNQZKUWKY-UHFFFAOYSA-N 4-Methyl-5H-furan-2-one Chemical class CC1=CC(=O)OC1 ZZEYQBNQZKUWKY-UHFFFAOYSA-N 0.000 description 1
- INAXVXBDKKUCGI-UHFFFAOYSA-N 4-hydroxy-2,5-dimethylfuran-3-one Chemical compound CC1OC(C)=C(O)C1=O INAXVXBDKKUCGI-UHFFFAOYSA-N 0.000 description 1
- VGHBEMPMIVEGJP-UHFFFAOYSA-N 4-methyl-2h-furan-5-one Chemical class CC1=CCOC1=O VGHBEMPMIVEGJP-UHFFFAOYSA-N 0.000 description 1
- OUDFNZMQXZILJD-UHFFFAOYSA-N 5-methyl-2-furaldehyde Chemical compound CC1=CC=C(C=O)O1 OUDFNZMQXZILJD-UHFFFAOYSA-N 0.000 description 1
- 101100204059 Caenorhabditis elegans trap-2 gene Proteins 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- BGLUXFNVVSVEET-UHFFFAOYSA-N beta-angelica lactone Chemical compound CC1OC(=O)C=C1 BGLUXFNVVSVEET-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- MCFZBCCYOPSZLG-UHFFFAOYSA-N cyclopent-4-ene-1,3-dione Chemical compound O=C1CC(=O)C=C1 MCFZBCCYOPSZLG-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 235000019613 sensory perceptions of taste Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035923 taste sensation Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Cigarettes, Filters, And Manufacturing Of Filters (AREA)
Abstract
A cigarette smoke oral cavity deposition simulation device and method, the device includes smoke suction component, smoke deposition simulation cavity, smoke gathering component, suction component connected in turn, the simulation cavity is a sandwich type cylindrical cavity, and filter paper coated with artificial saliva is arranged along the inner wall of the cavity, the sandwich is connected with constant temperature circulating water; the smoke suction component comprises a three-way valve and a suction pipe, the suction pipe extends into the simulation cavity, and the end part of the suction pipe is closed and is uniformly provided with air holes. The invention is characterized in that: 1) the three-way valve controls the switching between the smoking and the suction of the cigarette, and the simulation of the smoking, the staying and the swallowing of the smoke in the oral cavity can be realized. 2) The air hole at the end of the suction pipe can ensure the full diffusion of the smoke in the cavity. 3) The cavity volume basically accords with the oral cavity volume, and filter paper is used for simulating the oral mucosa, adsorbs the flue gas in the cavity, and interbedded constant temperature circulating water can simulate the oral cavity temperature. 4) The trap can realize the trapping of swallowed smoke particle phase substances after the smoke stays and deposits in the oral cavity.
Description
Technical Field
The invention relates to the technical field of tobacco, in particular to a cigarette smoke oral deposition simulation device and method.
Background
During the smoking process of the cigarette, consumers feel the taste sensation of sweetness, sourness, bitterness and the like and the chemical sensation of stimulation, burning, cooling and the like through the oral cavity, and mainly originate from the deposition of cigarette mainstream smoke in the oral cavity. The method has the advantages that the deposition behavior of the mainstream smoke in the oral cavity is accurately mastered, and the method has important significance for further deeply researching the oral physiological feeling and physiological mechanism of the cigarette consumers on the smoke. However, at present, an analysis means for the oral deposition of the smoke is lacked, and related researches are difficult to deeply develop. CN102128913A discloses an oral cavity simulator and a method for evaluating cigarette smoke irritation components; CN105021741A discloses an analysis method and a device of bionic absorption liquid of mainstream smoke; CN101718645A discloses a bionic absorption interaction device for simulating human mouth to mainstream smoke; CN206057033U discloses an artificial oral device. The methods provide references for the research of the oral deposition behavior of the mainstream smoke of the cigarettes, but have defects in the aspects of cavity structure design, airflow control, temperature control and the like, and have great difference with the real conditions of the processes of inhalation, stay, adsorption and the like of the smoke in the oral cavity, and the simulation effect of the oral deposition behavior of the smoke needs to be further improved.
Disclosure of Invention
The invention aims to provide a device and a method for simulating the deposition of cigarette smoke in the oral cavity based on the current situation, and the device and the method can better simulate the deposition behavior of the cigarette smoke in the oral cavity through the comprehensive design of the cavity structure, the air flow transmission, the temperature control and the like, thereby providing an effective technical means for the development of related researches.
The aim of the invention is achieved by the following technical measures:
a cigarette smoke oral deposition simulation device comprises a smoke suction component, a smoke deposition simulation cavity, a smoke collecting component and a suction component which are connected in sequence,
the deposition simulation cavity is a sandwich cylindrical cavity, the axial two ends of the cavity are provided with an air inlet and an air outlet which are respectively communicated with the smoke suction component and the smoke trapping component, and the volume of the inner cavity is 30-60cm3The filter paper coated with artificial saliva is arranged along the inner wall, and a water inlet and a water outlet are respectively arranged at the two ends of the interlayer cavity and used for connecting constant-temperature circulating water;
the smoke suction part is composed of a three-way valve and a suction pipe, one port of the three-way valve is a cigarette insertion section, the other port of the three-way valve is connected with the suction pipe together with the port of the central line, the third port of the three-way valve is communicated with the air, the suction pipe is connected with an air inlet of the smoke deposition simulation cavity through a ground rubber plug and extends into the cavity, the end part of the suction pipe extending into the cavity is of a closed structure, and a plurality of air holes are uniformly distributed on the end surface and the side surface of the closed end.
The flue gas deposition simulation cavity is a sandwich type cylindrical cavity made of glass.
The smoke suction component, the smoke deposition simulation cavity, the smoke trapping component and the suction component are arranged on the same center line.
The temperature of the constant-temperature circulating water is consistent with the temperature of the oral cavity of the human body.
The smoke trapping part is a trap internally provided with a Cambridge filter disc, and the suction part is a single-pore-passage smoking machine.
The suction pipe is a glass pipe with the same diameter as the cigarette, and the aperture of the air holes uniformly distributed on the end face and the side face of the closed end of the suction pipe is 0.2-1 mm.
The method for simulating the oral cavity deposition of the mainstream smoke of the cigarette by using the device mainly comprises the following steps:
(1) controlling the temperature of the cavity through a cavity constant-temperature backflow interlayer in the device;
(2) smoking cigarettes through a single-hole smoking machine in the device;
(3) after smoking, the smoke stays in the cavity and is deposited on the artificial saliva coated filter paper;
(4) and after the smoke stays in the cavity for a certain time, switching the three-way valve, performing air suction through the single-channel smoking machine, pumping out the smoke staying in the cavity, and capturing particulate matters through a trap in the device to realize analysis and research on the oral deposition behavior of the mainstream smoke of the cigarettes.
The method of the invention can realize the simulation of 3 processes of inhalation, stay, swallowing and the like of the smoke in the oral cavity.
The main parts of the invention have the following design points and main functions:
the three-way valve is used for realizing the switching between cigarette suction and air suction. When the cigarette is sucked, the port of the suction pipe is communicated with the port of the cigarette, and the air port is closed; during air suction, the port of the suction pipe is communicated with the air port, and the port of the cigarette is closed. The suction pipe is a glass pipe with the same diameter as the cigarette and is connected with the ground of the smoke deposition simulation cavity through a rubber plug. One end of the suction pipe connected with the cavity is closed, but the end surface and the side surface of the closed end part are provided with a plurality of air holes. The main purpose of the air hole design is to prevent the smoke from passing through the cavity in a straight line due to the suction inertia, so that the smoke is uniformly diffused in the cavity. The flue gas deposition simulation cavity is a sandwich type cylindrical cavity made of glass, wherein the volume of the inner cavity is 30-60cm3And the filter paper coated with artificial saliva is placed on the inner wall of the smoke-depositing carrier. The two ends of the interlayer cavity are respectively provided with a water inlet and a water outlet which can be connected with constant-temperature circulating water, thereby realizing the temperature control of the inner cavity. The air outlet end of the simulation cavity is connected with a flue gas catcher which clamps the cambridge filter disc. When the cigarette is sucked, the smoke firstly enters the smoke for diffusion and deposition, then the smoke is switched into air suction, so that the smoke in the cavity is discharged, and the particulate matters after the smoke deposition are collected by the catcher. The other end of the smoke catcher is connected with the single-pore smoke sucking machine.
The invention is characterized in that: (1) the three-way valve controls the switching between the smoking and the air smoking, and the simulation of 3 processes of smoking, staying, swallowing and the like of the smoke in the oral cavity can be effectively realized. (2) The hole punching of the suction port of the suction pipe can ensure the sufficient diffusion of the smoke in the cavity. (3) The volume of the cavity basically accords with the volume of the oral cavity, the filter paper coated with artificial saliva is used for simulating the mucous membrane of the oral cavity, the smoke in the cavity is adsorbed, and the constant-temperature circulating water of the interlayer can simulate the temperature of the oral cavity. (4) The trap can realize the trapping of swallowed smoke particle phase substances after the smoke stays and deposits in the oral cavity.
Drawings
FIG. 1 is a schematic structural diagram of a simulation apparatus according to the present invention.
In the figure: 1 single-hole smoke suction machine; 2, a trap; 3 cambridge filter disc; 4 constant temperature reflux cavity (4-1 water inlet, 4-2 water outlet); 5, a cavity; 6, filtering paper; 7 grinding the rubber plug; 8, a suction pipe; 9 a three-way valve; 10 an air inlet; 11 cigarettes.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
as shown in fig. 1: a cigarette smoke oral deposition simulation device comprises a smoke suction component, a smoke deposition simulation cavity 5, a smoke trapping component (namely a trap 2 provided with a Cambridge filter disc 3) and a suction component (namely a single-pore smoking machine 1) which are sequentially connected, wherein the components are arranged on the same central line.
The deposition simulation cavity 5 is a sandwich cylindrical cavity made of glass, air inlets and air outlets are arranged at two axial ends of the cavity and are respectively communicated with the smoke suction component and the smoke collecting component, and the volume of an inner cavity is 30-60cm3And the inner wall is provided with filter paper 6 coated with artificial saliva, the two ends of the interlayer cavity (namely the constant-temperature backflow cavity 4) are respectively provided with a water inlet 4-1 and a water outlet 4-2 for connecting constant-temperature circulating water, and the temperature of the constant-temperature circulating water is consistent with the temperature of the oral cavity of a human body.
The flue gas inhales the part and comprises three-way valve 9 and suction tube 8, 9 ports of three-way valve are a cigarette 11 and insert the section, another with it with the port of central line with suction tube 8 be connected, third port (air inlet 10 promptly) communicates with each other with the air, suction tube 8 is continuous with the air inlet of flue gas deposit simulation cavity 5 through grinding mouthful plug 7 and is extended to the intracavity, the suction tube tip that extends to the intracavity is closed structure, and the terminal surface and the side equipartition at the blind end have a plurality of gas pockets (the gas pocket aperture is 0.2-1 mm), the suction tube is the glass material diameter and props up the cigarette the same.
More specifically: a cigarette smoke oral deposition simulation device comprises a smoke suction component, a smoke deposition simulation cavity, a smoke trapping component and a suction component. Wherein, the smoke suction component consists of a three-way valve 9 and a suction pipe 8. One port of the three-way valve is inserted into a cigarette 11, the other horizontal port is connected with the suction pipe 8, and the third port is an air inlet 10. When the cigarette is sucked, the port of the suction pipe is communicated with the port of the cigarette, the air port is closed, when the cigarette is sucked in an empty mode, the port of the suction pipe is communicated with the air inlet 10, and the port of the cigarette is closed, so that the switching between the cigarette suction and the empty suction can be realized. The suction pipe 8 is connected with the grinding port of the smoke deposition simulation cavity through a rubber plug 7. One end of the suction pipe 8 connected with the cavity is closed, but the end surface and the side surface of the closed end part are provided with a plurality of air holes. The main purpose of the air hole design is to prevent the smoke from passing through the cavity in a straight line due to the suction inertia, so that the smoke is uniformly diffused in the cavity. The flue gas deposition simulation cavity is a sandwich type cylindrical cavity made of glass, wherein the volume of the inner cavity is 30-60cm3And on the inner wall of which is placed a filter paper 6 coated with artificial saliva, as a deposition carrier for fumes. The two ends of the interlayer cavity (namely the constant-temperature backflow cavity 4) are respectively provided with a water inlet 4-1 and a water outlet 4-2 which can be connected with constant-temperature circulating water to realize the temperature control of the inner cavity. The air outlet end of the simulation cavity is connected with a flue gas catcher 2 which clamps a cambridge filter 3. The other end of the smoke catcher is connected with the single-pore smoke sucking machine 1. When the cigarette is sucked, the smoke firstly enters the cavity 5 for diffusion and deposition, then the cavity is switched into an empty suction mode, so that the smoke in the cavity is discharged, and the particulate matters after the smoke deposition are collected by the collector 2.
The invention will be described in further detail below with reference to specific pumping and analysis examples.
Example 1
The filter paper of 4cm x 8cm coated with 0.5ml of artificial saliva is placed annularly along the inner wall of the simulated cavity, the constant temperature reflux water is adjusted to 37 ℃, and all parts of the device are connected, and then the cigarette sample is inserted into the cigarette end of the triangular valve. The smoking capacity of the single-channel smoking machine is 35mL, the smoking time is 2s, and the smoking period is 10 s. The residence time of the fumes in the chamber is 8s during this suction cycle. After smoking of the cigarette is finished, the triangular valve is switched to the air end during the retention period of the smoke, and when the smoking machine smokes again according to the smoking parameters, the smoke in the cavity is pumped out, and the particulate matter deposited by the smoke is collected by the catcher. Repeating the steps, and smoking 10 mouths for each cigarette. According to the smoking method, 5 cigarettes are smoked, the deposit of the smoke in the simulation cavity is collected on the filter paper coated with the artificial saliva, and the particle phase matter after the smoke deposition is collected on the Cambridge filter sheet in the catcher. The deposition condition of the volatile carbonyl compounds in the mainstream smoke of the cigarette sample A is analyzed by adopting a standard method YCT 254-. The analysis result shows that the device and the method can realize the analysis of the deposition behavior of the flue gas and have good stability.
TABLE 1 cigarette sample A deposition of volatile carbonyl compounds in the cigarette smoke (. mu.g/cigarette)
The cavity deposition amounts in the table refer to the measured carbonyl compounds collected on the filter paper.
Example 2
The filter paper of 4cm x 8cm coated with 0.5ml of artificial saliva is placed annularly along the inner wall of the simulated cavity, the constant temperature reflux water is adjusted to 37 ℃, and all parts of the device are connected, and then the cigarette sample is inserted into the cigarette end of the triangular valve. The smoking capacity of the single-channel smoking machine is 50mL, the smoking time is 2s, and the smoking period is 10 s. The residence time of the fumes in the chamber is 10s during this suction cycle. After smoking of the cigarette is finished, the triangular valve is switched to the air end during the retention period of the smoke, and when the smoking machine smokes again according to the smoking parameters, the smoke in the cavity is pumped out, and the particulate matter deposited by the smoke is collected by the catcher. Repeating the steps, and smoking 10 mouths for each cigarette. According to the smoking method, 5 cigarettes are smoked, the deposit of the smoke in the simulation cavity is collected on the filter paper coated with the artificial saliva, and the particle phase matter after the smoke deposition is collected on the Cambridge filter sheet in the catcher. The deposition of the sweet and brown components in the mainstream smoke of cigarette sample A was analyzed by GC/MS, and the results are shown in Table 2.
TABLE 1 cigarette sample A deposition of sweet component of tobacco tar (μ g/cigarette)
| Sweet component | Deposition volume of chamber | Amount of collected filter disc |
| Furfural | 40.50 | 34.97 |
| Furfuryl alcohol | 9.31 | 23.58 |
| Angelic lactone | 4.81 | 4.51 |
| 2-cyclopentene-1, 4-dione | 22.30 | 53.66 |
| 5-methylfurfural | 10.93 | 21.67 |
| 3-methyl-2-cyclopenten-1-one | 6.51 | 13.88 |
| 3-methyl-2 (5H) -furanones | 1.55 | 4.33 |
| Methyl cyclopentenolone | 6.84 | 41.34 |
| 4-methyl-2 (5H) furanones | 4.55 | 7.33 |
| 4-hydroxy-2, 5-dimethyl-3 (2H) -furanone | 3.84 | 48.05 |
| 3, 4-dimethylcyclopentenol ketones | 1.97 | 6.35 |
| Maltol | 12.92 | 39.85 |
| Ethyl cyclopentenolone | 3.12 | 13.57 |
Claims (10)
1. The utility model provides a cigarette flue gas oral cavity deposit analogue means which characterized in that: comprises a smoke suction component, a smoke deposition simulation cavity, a smoke trapping component and a suction component which are connected in sequence,
the deposition simulation cavity is a sandwich cylindrical cavity, the axial two ends of the cavity are provided with an air inlet and an air outlet which are respectively communicated with the smoke suction component and the smoke trapping component, and the volume of the inner cavity is 30-60cm3The filter paper coated with artificial saliva is arranged along the inner wall, and a water inlet and a water outlet are respectively arranged at the two ends of the interlayer cavity and used for connecting constant-temperature circulating water;
the smoke suction part is composed of a three-way valve and a suction pipe, one port of the three-way valve is a cigarette insertion section, the other port of the three-way valve is connected with the suction pipe together with the port of the central line, the third port of the three-way valve is communicated with the air, the suction pipe is connected with an air inlet of the smoke deposition simulation cavity through a ground rubber plug and extends into the cavity, the end part of the suction pipe extending into the cavity is of a closed structure, and a plurality of air holes are uniformly distributed on the end surface and the side surface of the closed end.
2. The cigarette smoke oral deposition simulator of claim 1, wherein: the flue gas deposition simulation cavity is a sandwich type cylindrical cavity made of glass.
3. The cigarette smoke oral deposition simulator of claim 1, wherein: the smoke suction component, the smoke deposition simulation cavity, the smoke trapping component and the suction component are arranged on the same center line.
4. The cigarette smoke oral deposition simulator of claim 1, wherein: the temperature of the constant-temperature circulating water is consistent with the temperature of the oral cavity of the human body.
5. The cigarette smoke oral deposition simulator of claim 1, wherein: the smoke trapping component is a trap internally provided with a cambridge filter disc.
6. The cigarette smoke oral deposition simulator of claim 1, wherein: the suction component is a single-pore-passage smoking machine.
7. The cigarette smoke oral deposition simulator of claim 1, wherein: the suction pipe is a glass pipe with the same diameter as the cigarette.
8. The cigarette smoke oral deposition simulator of claim 1, wherein: the aperture of the air holes uniformly distributed on the end face and the side face of the closed end of the suction pipe is 0.2-1 mm.
9. A method for simulating oral deposition of mainstream smoke in a cigarette by using the device of claim 1, wherein the method comprises the following steps: the method comprises the following steps:
(1) controlling the temperature of the cavity through a cavity constant-temperature backflow interlayer in the device;
(2) smoking cigarettes through a single-hole smoking machine in the device;
(3) after smoking, the smoke stays in the cavity and is deposited on the artificial saliva coated filter paper;
(4) and after the smoke stays in the cavity for a certain time, switching the three-way valve, performing air suction through the single-channel smoking machine, pumping out the smoke staying in the cavity, and capturing particulate matters through a trap in the device to realize analysis and research on the oral deposition behavior of the mainstream smoke of the cigarettes.
10. The method of simulating oral deposition of mainstream smoke from a cigarette of claim 9, wherein: the method can realize the simulation of 3 processes of inhalation, stay, swallowing and the like of the smoke in the oral cavity.
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| CN202110696265.XA CN113267434A (en) | 2021-06-23 | 2021-06-23 | Cigarette smoke oral deposition simulation device and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115932188A (en) * | 2023-03-15 | 2023-04-07 | 江南大学 | Cigarette mainstream smoke oral cavity bionic absorption device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115932188A (en) * | 2023-03-15 | 2023-04-07 | 江南大学 | Cigarette mainstream smoke oral cavity bionic absorption device |
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