CN113264491A

CN113264491A - Automatic quantitative liquid cell canning equipment used in biopharmaceutical process

Info

Publication number: CN113264491A
Application number: CN202110556772.3A
Authority: CN
Inventors: 陈郑辉
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-05-21
Filing date: 2021-05-21
Publication date: 2021-08-17

Abstract

The invention relates to the technical field of biological pharmacy, and discloses automatic quantitative liquid cell canning equipment used in a biological pharmacy process. Cell liquid through depositing the cistern inside gets into the leaf upper end of limiting, simultaneously, the carousel passes through the gangbar and drives the push rod downstream, the push rod passes through the rack and drives gear revolve, the gear passes through the rotor and drives the leaf rotation of limiting, the leaf of limiting will deposit the inside cell liquid of cistern through the recess in the outside and take out jar internal portion, and can avoid the cell liquid extrusion to appear through the leaf of limiting drives the cell liquid and carries out the canning, thereby reached and adopted flexible canning technique, avoided the cell liquid effect that extrusion deactivation appears at the canning in-process.

Description

Automatic quantitative liquid cell canning equipment used in biopharmaceutical process

Technical Field

The invention relates to the technical field of biological pharmacy, in particular to automatic quantitative liquid cell canning equipment used in a biological pharmacy process.

Background

With the continuous development of medical technology in China, the biopharmaceutical industry is also emerging, biopharmaceuticals can produce some important drugs, for example, drugs of cell products can be produced by cell culture, after the liquid cell culture of biopharmaceuticals is successful, the biopharmaceuticals usually need to be canned and then transported to hospitals for utilization, wherein the cells need to be prevented from being damaged by some external factors in the process of canning the liquid cells.

The liquid cell of current bio-pharmaceuticals is filling the jar although can realize the technique of automatic tinning, but the volume of filling each time that can not reasonable control when the canning reaches unanimity, the encapsulation for the jar body in the later stage brings huge difficulty, in addition, current cell can receive some equipment and cell and directly extrude when carrying out the canning, leads to the condition that some cells appear devitalizing, and the cell after the devitalizing can not play good treatment in the use.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides automatic quantitative liquid cell canning equipment for a biopharmaceutical process, which has the advantages of automatic quantitative canning in the canning process, avoiding the phenomenon that the later sealing is affected due to the inconsistent canning amount in each canning process, having high canning efficiency, adopting a flexible canning technology, avoiding the extrusion inactivation in the canning process of cell sap and the like, and solves the problems that the automatic quantitative canning in the canning process cannot be carried out by the common biological cell canning equipment, the later sealing is affected due to the inconsistent canning amount in each canning process, the canning efficiency is low, the flexible canning technology cannot be adopted, and the extrusion inactivation occurs in the canning process of the cell sap.

(II) technical scheme

In order to realize the purposes of automatically and quantitatively filling in the canning process, avoiding the phenomenon that the later sealing is influenced by the inconsistent canning amount in each canning process, having high canning efficiency, adopting a flexible canning technology and avoiding extrusion inactivation in the canning process of cell sap, the invention provides the following technical scheme:

the utility model provides an automatic ration canning equipment of liquid cell for bio-pharmaceuticals in-process, includes the support, support upper end fixedly connected with central authorities board, the inside cistern that is provided with of central authorities board, the inside centre of central authorities board has the feed liquor fill by last fixed grafting, and feed liquor fill right-hand member fixedly connected with dead lever, the fixed section of thick bamboo of dead lever lower extreme fixedly connected with, the inside activity of dead lever is pegged graft and is had the pull rod.

Preferably, the outside of the pull rod is movably sleeved with a thrust spring inside the fixed cylinder, the lower end of the thrust spring is fixedly connected with a baffle, the baffle is in a step shape, the baffle can separate cell liquid inside the liquid storage groove to prevent the cell liquid from being extruded to cause inactivation, and holes are formed in the outside of the baffle and inside the central plate.

Preferably, the dead lever upper end fixedly connected with carousel, the gangbar has been cup jointed by preceding activity in the carousel outside, can adjust the position that the pull rod can the push rod simultaneously for simple structure, the inside activity of right side of gangbar is pegged graft and is had the push rod, and the push rod outside just lies in the inside fixed cover of central authorities board and has connect the stopper, and the reset spring has been cup jointed in the push rod outside just lies in the stopper lower extreme activity.

Preferably, the lower end of the central plate is close to the right fixedly connected with control box, the control box is internally plugged with a rack close to the right movably, the left end of the rack is meshed with a gear, the upper end of the rack is fixedly connected with a return spring, and the return spring can control the position of the push rod by pushing the limiting block.

Preferably, the rotor is movably inserted in the control box towards the left, the limiting blade is movably sleeved on the outer side of the rotor, a notch is formed in the outer side of the limiting blade, gear teeth matched with the gear are arranged on the outer side of the rotor towards the rear, and the gear can drive the rotor to rotate while rotating.

Preferably, fixedly connected with tray in the middle of the support is inside, and the inside activity of tray is pegged graft and is had adjusting spring, and the adjusting spring upper end just is located the inside fixedly connected with fixture block of support, and the fixture block can be used to carry out the separation with the jar body, prevents that the out of order from appearing in the jar body, and the fixture block right-hand member is provided with the inclined hole, and the fixture block upper end sets up to the slope form, and the support upper end leans on right swing joint to have a jar body.

Preferably, the middle of the right end of the bracket is movably connected with a support frame, the right end of the support frame is movably connected with a connecting rod, the lower end of the connecting rod is movably connected with a sliding block, the right end of the sliding block is fixedly connected with a tension spring inside the bracket, the left end of the sliding block is fixedly connected with a wedge rod, and the left end of the wedge rod is matched with a hole in the right end of the clamping block, so that the clamping block can be adjusted to move downwards when the wedge rod moves leftwards inside the clamping block.

(III) advantageous effects

Compared with the prior art, the invention provides automatic quantitative liquid cell canning equipment used in the biopharmaceutical process, which has the following beneficial effects:

1. this an automatic ration canning equipment for liquid cell among bio-pharmaceuticals process, through putting into the feed liquor fill with cell liquid inside, cell liquid flows to the liquid storage tank inside along advancing the liquid fill, rotate the carousel right, the carousel passes through the gangbar and drives the pull rod rebound, the pull rod drives baffle compression thrust spring rebound, make the inside cell liquid of liquid storage tank get into the upper end of limiting quantity leaf, and simultaneously, the carousel passes through the gangbar and drives the push rod rebound, the push rod passes through rack drive gear revolve, the gear passes through the rotor and drives the leaf rotation of limiting quantity, the leaf of limiting quantity takes out the inside cell liquid of liquid storage tank to jar internal portion through the recess in the outside, and carry out the canning through the leaf of limiting quantity and can avoid the cell liquid extrusion to appear, thereby reached and adopted flexible canning technique, avoid appearing the effect of extrusion deactivation at the cell liquid canning in-process.

2. This a liquid cell automatic ration canning equipment for bio-pharmaceuticals in-process, through limiting the jar body that the leaf drove cell liquid entering strut upper end, the pressure increase of the jar body for the strut, the strut rotates round the support and drives slider tensile tension spring left through the connecting rod, the slider drives the wedge rod and moves left, make the wedge rod left end get into inside the fixture block, the wedge rod drives the fixture block through the left end with the inclined hole cooperation inside the fixture block and compress the regulating spring downwards, when the jar body is pressed the strut to the bottom, the jar body slides to the upper end of support from the strut upper end and leans on the left position, and the fixture block will allow the jar body of left end to release to the strut upper end, thereby reached and to carry out automatic ration canning when the canning, the inconsistent effect that influences the seal of later stage of canning, the efficient effect of canning appears when avoiding every canning.

Drawings

FIG. 1 is a front elevational full sectional view of the structure of the present invention;

FIG. 2 is an enlarged view of the structure of the present invention at A in FIG. 1;

FIG. 3 is an enlarged view of the structure of the present invention at B in FIG. 1;

fig. 4 is an enlarged view of the inventive structure at C in fig. 1.

In the figure: 1. a support; 2. a central plate; 3. a liquid storage tank; 4. a liquid inlet hopper; 5. fixing the rod; 6. a fixed cylinder; 7. a pull rod; 8. a thrust spring; 9. a baffle plate; 10. a turntable; 11. a linkage rod; 12. a push rod; 13. a limiting block; 14. a return spring; 15. a rack; 16. a control box; 17. a gear; 18. a rotor; 19. limiting the leaf quantity; 20. a tray; 21. adjusting the spring; 22. a clamping block; 23. a tank body; 24. a support frame; 25. a connecting rod; 26. a slider; 27. a tension spring; 28. a wedge rod.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-4, an automatic quantitative liquid cell canning device for biopharmaceutical process comprises a frame 1, a support frame 24 is movably connected in the middle of the right end of the frame 1, a connecting rod 25 is movably connected to the right end of the support frame 24, a sliding block 26 is movably connected to the lower end of the connecting rod 25, a tension spring 27 is fixedly connected to the right end of the sliding block 26 and located inside the frame 1, a wedge rod 28 is fixedly connected to the left end of the sliding block 26, the left end of the wedge rod 28 is provided with a hole matched with the right end of a clamping block 22, so that the clamping block 22 can be moved downwards when the wedge rod 28 moves leftwards along the inside of the clamping block 22, a tray 20 is fixedly connected in the middle of the frame 1, an adjusting spring 21 is movably inserted in the tray 20, the clamping block 22 is fixedly connected to the upper end of the adjusting spring 21 and located inside the frame 1, the clamping block 22 can be used for blocking a tank body 23 to prevent the tank body 23 from disorder, an inclined hole is provided at the right end of the clamping block 22, the upper end of the clamping block 22 is arranged to be inclined, the upper end of the bracket 1 is movably connected with a tank body 23 close to the right, the upper end of the bracket 1 is fixedly connected with a central plate 2, the lower end of the central plate 2 is fixedly connected with a control box 16 close to the right, a rotor 18 is movably inserted in the control box 16 close to the left, a quantity-limiting leaf 19 is movably sleeved on the outer side of the rotor 18, a notch is arranged on the outer side of the quantity-limiting leaf 19, gear teeth matched with a gear 17 are arranged on the outer side of the rotor 18 close to the rear, the gear 17 can drive the rotor 18 to rotate while rotating, a rack 15 is movably inserted in the control box 16 close to the right, the left end of the rack 15 is meshed with the gear 17, the upper end of the rack 15 is fixedly connected with a reset spring 14, the reset spring 14 can push a limit block 13 to control the position of a push rod 12, a liquid storage tank 3 is arranged in the central plate 2, a liquid inlet hopper 4 is fixedly inserted in the middle of the central plate 2 close to the upper end, and a fixed rod 5 is fixedly connected with the right end of the liquid inlet hopper 4, the utility model discloses a cell liquid storage tank, including dead lever 5, 5 upper end fixedly connected with carousel 10 of dead lever, the gangbar 11 has been cup jointed by preceding activity in the carousel 10 outside, but the position of regulating pull rod 7 push rod 12 simultaneously, make simple structure, the inside right activity of leaning on of gangbar 11 is pegged graft and is had push rod 12, the push rod 12 outside just is located 2 inside fixed cup joints of central authorities and has been had stopper 13, reset spring 14 has been cup jointed in the push rod 12 outside and is located 13 lower extreme activities of stopper, 5 lower extreme fixedly connected with fixed section of thick bamboo 6 of dead lever, the inside activity of dead lever 5 is pegged graft and is had pull rod 7, the pull rod 7 outside just is located fixed section of thick bamboo 6 inside activity and has been cup jointed thrust spring 8, 8 lower extreme fixedly connected with baffle 9 of thrust spring, baffle 9 sets up to the echelonment, baffle 9 can separate the cell liquid of 3 inside in the liquid storage tank, prevent that the cell liquid from taking place to extrude and lead to the deactivation, baffle 9 outside and be located 2 inside and set up porosely.

The working principle is as follows: when the cell liquid storage tank is used, cell liquid can be placed into the liquid inlet hopper 4, flows into the liquid storage tank 3 along the liquid inlet hopper 4, the tank body 23 is placed at the left position of the upper end of the support 1, the cell liquid can be placed into the liquid inlet hopper 4, the rotary table 10 is rotated rightwards, the rotary table 10 drives the pull rod 7 to move upwards through the linkage rod 11, the pull rod 7 drives the baffle 9 to compress the thrust spring 8 to move upwards, so that the cell liquid in the liquid storage tank 3 enters the upper end of the quantity limiting blade 19, meanwhile, the rotary table 10 drives the push rod 12 to move downwards through the linkage rod 11, the push rod 12 drives the gear 17 to rotate through the rack 15, the gear 17 drives the quantity limiting blade 19 to rotate through the rotor 18, the quantity limiting blade 19 brings the cell liquid in the liquid storage tank 3 into the tank body 23 through the groove on the outer side, and the cell liquid is driven by the quantity limiting blade 19 to be filled into the tank, so that the extrusion of the cell liquid can be avoided, thereby achieving the effect of adopting flexible canning technology and avoiding extrusion inactivation in the canning process of cell sap, along with the increase of pressure of the pot 23 on the support frame 24 when the cell sap is driven by the limit blade 19 to enter the pot 23 at the upper end of the support frame 24, the support frame 24 rotates around the support frame 1 and drives the slide block 26 to stretch the tension spring 27 leftwards through the connecting rod 25, the slide block 26 drives the wedge rod 28 to move leftwards, so that the left end of the wedge rod 28 enters the fixture block 22, the wedge rod 28 drives the fixture block 22 to compress the adjusting spring 21 downwards through the left end matched with the inclined hole in the fixture block 22, when the pot 23 presses the support frame 24 to the bottom end, the pot 23 slides to the left position at the upper end of the support frame 1 from the upper end of the support frame 24, and the fixture block 22 allows the pot 23 at the left end to be released to the upper end of the support frame 24, thereby achieving the effects of automatic quantitative canning and avoiding the influence of later-stage sealing due to inconsistent canning amount during each time of canning, The effect of high canning efficiency.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A liquid cell automatic quantitative canning equipment for among bio-pharmaceuticals process, includes support (1), its characterized in that: the support is characterized in that a central plate (2) is fixedly connected to the upper end of the support (1), a liquid storage tank (3) is arranged inside the central plate (2), a liquid inlet hopper (4) is fixedly inserted in the middle of the inside of the central plate (2) by upper connection, a fixing rod (5) is fixedly connected to the right end of the liquid inlet hopper (4), a fixing cylinder (6) is fixedly connected to the lower end of the fixing rod (5), and a pull rod (7) is movably inserted in the fixing rod (5).

2. The apparatus of claim 1 for automated liquid cell quantification in biopharmaceutical processes, wherein: the outer side of the pull rod (7) is located inside the fixed cylinder (6) and is movably sleeved with a thrust spring (8), the lower end of the thrust spring (8) is fixedly connected with a baffle (9), the baffle (9) is arranged in a step shape, and holes are formed in the outer side of the baffle (9) and located inside the central plate (2).

3. The apparatus of claim 1 for automated liquid cell quantification in biopharmaceutical processes, wherein: the upper end of the fixed rod (5) is fixedly connected with a rotary table (10), a linkage rod (11) is movably sleeved on the outer side of the rotary table (10) by virtue of the front, a push rod (12) is movably inserted into the linkage rod (11) by virtue of the right, a limit block (13) is fixedly sleeved on the outer side of the push rod (12) and positioned inside the central plate (2), and a reset spring (14) is movably sleeved on the outer side of the push rod (12) and positioned at the lower end of the limit block (13).

4. The apparatus of claim 1 for automated liquid cell quantification in biopharmaceutical processes, wherein: the lower end of the central plate (2) is fixedly connected with a control box (16) close to the right, a rack (15) is movably inserted into the control box (16) close to the right, the left end of the rack (15) is meshed with a gear (17), and the upper end of the rack (15) is fixedly connected with a return spring (14).

5. The apparatus of claim 4 for automated liquid cell quantification in biopharmaceutical processes, wherein: the rotor (18) is movably inserted into the control box (16) close to the left, the limiting blade (19) is movably sleeved on the outer side of the rotor (18), a notch is formed in the outer side of the limiting blade (19), and gear teeth matched with the gear (17) are arranged close to the rear of the outer side of the rotor (18).

6. The apparatus of claim 1 for automated liquid cell quantification in biopharmaceutical processes, wherein: fixedly connected with tray (20) in the middle of support (1) is inside, and the inside activity of tray (20) is pegged graft and is had adjusting spring (21), and adjusting spring (21) upper end just is located support (1) inside fixedly connected with fixture block (22), and fixture block (22) right-hand member is provided with the inclined hole, and fixture block (22) upper end sets up to the slope form, and support (1) upper end leans on right swing joint to have jar body (23).

7. The apparatus of claim 1 for automated liquid cell quantification in biopharmaceutical processes, wherein: the middle of the right end of the support (1) is movably connected with a support frame (24), the right end of the support frame (24) is movably connected with a connecting rod (25), the lower end of the connecting rod (25) is movably connected with a sliding block (26), the right end of the sliding block (26) is located inside the support (1) and fixedly connected with a tension spring (27), the left end of the sliding block (26) is fixedly connected with a wedge rod (28), and the left end of the wedge rod (28) is arranged to be matched with a hole at the right end of the clamping block (22).