CN113262165A - Automatic pharmaceutical production line and process - Google Patents
Automatic pharmaceutical production line and process Download PDFInfo
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- CN113262165A CN113262165A CN202110545367.1A CN202110545367A CN113262165A CN 113262165 A CN113262165 A CN 113262165A CN 202110545367 A CN202110545367 A CN 202110545367A CN 113262165 A CN113262165 A CN 113262165A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 19
- 230000007246 mechanism Effects 0.000 claims abstract description 209
- 239000000463 material Substances 0.000 claims abstract description 87
- 238000002156 mixing Methods 0.000 claims abstract description 56
- 238000003756 stirring Methods 0.000 claims abstract description 56
- 238000011049 filling Methods 0.000 claims abstract description 54
- 238000001816 cooling Methods 0.000 claims abstract description 51
- 238000001179 sorption measurement Methods 0.000 claims abstract description 49
- 239000002994 raw material Substances 0.000 claims abstract description 45
- 239000002912 waste gas Substances 0.000 claims abstract description 41
- 238000001914 filtration Methods 0.000 claims abstract description 38
- 239000003814 drug Substances 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000001035 drying Methods 0.000 claims abstract description 26
- 239000002131 composite material Substances 0.000 claims abstract description 24
- 238000012856 packing Methods 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000007599 discharging Methods 0.000 claims description 22
- 239000000498 cooling water Substances 0.000 claims description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 6
- 239000000428 dust Substances 0.000 claims description 4
- 239000013013 elastic material Substances 0.000 claims description 4
- 238000005192 partition Methods 0.000 claims description 4
- 239000000779 smoke Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 11
- 239000000112 cooling gas Substances 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 10
- 230000007306 turnover Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000003028 elevating effect Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 230000001174 ascending effect Effects 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000010815 organic waste Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/56—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
- B01D53/04—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
- B01D53/0407—Constructional details of adsorbing systems
- B01D53/0415—Beds in cartridges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
- B01D53/04—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
- B01D53/0454—Controlling adsorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
- B01F33/831—Devices with consecutive working receptacles, e.g. with two intermeshing tools in one of the receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C13/00—Disintegrating by mills having rotary beater elements ; Hammer mills
- B02C13/02—Disintegrating by mills having rotary beater elements ; Hammer mills with horizontal rotor shaft
- B02C13/06—Disintegrating by mills having rotary beater elements ; Hammer mills with horizontal rotor shaft with beaters rigidly connected to the rotor
- B02C13/09—Disintegrating by mills having rotary beater elements ; Hammer mills with horizontal rotor shaft with beaters rigidly connected to the rotor and throwing the material against an anvil or impact plate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C13/00—Disintegrating by mills having rotary beater elements ; Hammer mills
- B02C13/13—Disintegrating by mills having rotary beater elements ; Hammer mills with horizontal rotor shaft and combined with sifting devices, e.g. for making powdered fuel
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Processing Of Solid Wastes (AREA)
Abstract
The invention discloses an automatic pharmaceutical production line and a process, which relate to the technical field of pharmacy and comprise a raw material crushing mechanism, an anti-blocking conveying mechanism, a raw material drying mechanism, a horizontal conveying line, a packing auger feeding mechanism, a composite dissolving tank, a mixing and stirring tank, a filter and a medicine filling mechanism which are sequentially connected according to a preparation flow, wherein the raw material drying mechanism comprises a waste gas outlet which is connected with a combined waste gas treatment system, the combined waste gas treatment system comprises an adjustable adsorption mechanism, a high-efficiency filtering mechanism and an air draft mechanism which are sequentially arranged, a circulating water cooling system is arranged between the filter and the medicine filling mechanism, and a feeding port of the mixing and stirring tank is also provided with an auxiliary material feeding system; the invention has the advantages of simple structure, high automation degree, good crushing effect, no blockage, good cooling and waste gas treatment effects and high working efficiency.
Description
Technical Field
The invention relates to the technical field of pharmacy, in particular to the technical field of an automatic pharmacy production line and a process.
Background
The pharmaceutical engineering is a science and technology specialty crossed with chemistry, biology, pharmacy (traditional Chinese medicine) and engineering, aims to develop and manufacture medicines, develop, amplify and design new processes, new equipment and new varieties, and is a new talent.
The existing equipment for sterilizing and drying raw material powder and chemical powder is independent production equipment which is prepared by mixing and manufacturing a plurality of intermittent processes, a turnover device or manpower is needed to be arranged among the processes for turnover, and a container and the powder are exposed in a working environment for a plurality of times, so that the dried and cooled raw material is easily exposed in the air, and secondary pollution is generated.
Meanwhile, a large amount of dust and organic waste gas are generated in many links in the pharmaceutical production process, and the main components in the waste gas are toluene, methanol, hydrogen chloride and the like. The waste gas treatment process adopted by the ocular drug enterprises has a single treatment mode, and has the problems of low treatment efficiency, high operation cost, serious secondary pollution and the like.
The raw material crushing equipment of the existing pharmaceutical system also has the defects of inconvenient and incomplete discharging and poor cooling effect.
How to solve the above technical problems has been the direction of efforts of those skilled in the art.
Disclosure of Invention
The invention aims to: in order to solve the technical problems, the invention provides an automatic pharmaceutical production line and a process.
The invention specifically adopts the following technical scheme for realizing the purpose:
an automatic pharmaceutical production line comprises a raw material crushing mechanism, an anti-blocking conveying mechanism, a raw material drying mechanism, a horizontal conveying line, a packing auger feeding mechanism, a composite dissolving tank, a mixing stirring tank, a filter and a medicine filling mechanism which are sequentially connected according to a preparation flow, wherein the raw material drying mechanism comprises a waste gas outlet, the waste gas outlet is connected with a combined waste gas treatment system, the waste gas outlet of the composite dissolving tank and the waste gas outlet of the mixing stirring tank are communicated with the inlet of the combined waste gas treatment system through a pipeline, the combined waste gas treatment system comprises an adjustable adsorption mechanism, a high-efficiency filtering mechanism and an air draft mechanism which are sequentially arranged, a circulating water cooling system is arranged between the filter and the medicine filling mechanism, a feed inlet of the mixing stirring tank is also provided with an auxiliary material feeding system, the raw material crushing mechanism comprises a crushing cavity and a discharge cavity communicated through a filtering screen, broken chamber top is provided with the feed inlet, and ejection of compact chamber lateral wall bottom is provided with the discharge gate that makes things convenient for the ejection of compact, ejection of compact intracavity portion is provided with the pushing equipment who pushes the discharge gate position to the material after smashing, ejection of compact intracavity top is kept away from discharge gate one side and is provided with elasticity guide subassembly.
Furthermore, a crushing disc is arranged in the crushing cavity, a plurality of main crushing teeth are uniformly distributed on the circumference of the crushing disc, and a plurality of auxiliary crushing teeth matched with the main crushing teeth are arranged on the inner wall of the crushing cavity;
the elastic material guide assembly comprises an inclined material guide plate hinged to one side of the filtering screen, which is far away from the discharge port, and an elastic support mechanism arranged in the discharge cavity and connected with the inclined material guide plate, wherein the elastic support mechanism is a support spring;
the pushing mechanism comprises a special-shaped pushing plate capable of reciprocating at the bottom of the discharging cavity and a linear driving mechanism for driving the special-shaped pushing plate to move, the linear driving mechanism is a screw nut driving assembly or a linear driving cylinder, the special-shaped pushing plate comprises a vertical plate and a pushing bottom plate, the vertical plate is vertically arranged, the pushing bottom plate is arranged at the bottom of the vertical plate and attached to the bottom of the discharging cavity, the upper surface of the pushing bottom plate is obliquely arranged, the cross section of the pushing bottom plate is in a right triangle shape, and two right-angle sides of the pushing bottom plate are respectively connected with the vertical plate and the bottom of the discharging cavity.
Furthermore, the adjustable adsorption mechanism comprises an adsorption shell, and an air inlet and an air outlet which are communicated with the interior of the adsorption shell, and an adjustable adsorption component and a plurality of activated carbon adsorption blocks which are arranged in parallel are sequentially arranged in the adsorption shell along the airflow direction;
adsorption component includes that both ends fix the adsorption piece that the range upon range of setting of connecting rod, the movable connecting rod that both ends are free in the adsorption casing and polylith, and all adsorb the piece with all equidistant articulated with the connecting rod, all adsorb other one side of piece and all equidistant articulated with movable connecting rod, it is provided with the adsorption piece pivoted actuating mechanism of drive bottommost to adsorb casing bottom, actuating mechanism for driving actuating cylinder.
Further, high efficiency filter mechanism includes the casing and sets up air intake and the air outlet at casing both ends and the inside intercommunication of casing, the casing is inside to be held to the air-out end from the air inlet and has set gradually just imitate filter mechanism, well imitate filter mechanism and high efficiency filter mechanism, just imitate filter mechanism and high efficiency filter mechanism and be the filter screen, just imitate filter mechanism's filter screen mesh and be greater than high efficiency filter mechanism's filter screen mesh.
Further, well effect filter mechanism is including setting up the filter chamber at the casing middle part, the filter chamber is close to air intake one side top and is provided with the ventilation hole, the filter chamber is close to air outlet one side bottom and is provided with the ventilation hole, the filter chamber from the top down inclines in proper order and is provided with the same filter screen of multilayer structure, well effect filter mechanism's filter screen mesh diameter is between just effect filter mechanism's filter screen mesh diameter and high efficiency filter mechanism's filter screen mesh diameter.
Further, the mixing and stirring tank comprises a mixing tank body, a feeding hole and a discharging hole, wherein the mixing tank body is communicated with the top and the bottom of the mixing tank body, a heat-insulating shell is sleeved on the outer side of the mixing tank body, a supporting foot rest is arranged at the bottom of the outer side of the heat-insulating shell, a moving roller is arranged at the bottom of the supporting foot rest, a brake assembly is arranged on the moving roller, a composite stirring assembly is arranged inside the mixing tank body, the composite stirring assembly comprises a stirring shaft positioned in the mixing tank body and a driving motor, the top of the mixing tank body drives the stirring shaft to rotate, and a stirring horizontal stirring assembly and a U-shaped stirring assembly are arranged on the stirring shaft.
U type stirring subassembly includes the ascending U type puddler of opening, the end of (mixing) shaft and the bottom fixed connection in the U type puddler, U type puddler inboard and the outside are provided with boss and supplementary stirring piece respectively, and the boss is connected with the agitator shaft.
Further, auxiliary material charging system is including a plurality of medicine tanks that set up side by side, and all discharge gates that add the medicine tank all are connected with the feed inlet of the blending tank body through the pipeline, and every discharge gate that adds the medicine tank all is provided with the solenoid valve.
Furthermore, the circulating water cooling system comprises a primary cooling mechanism, a secondary cooling mechanism and a circulating water tank, the material pipelines of the primary cooling mechanism and the secondary cooling mechanism are communicated, a cooling water outlet of the primary cooling mechanism is communicated with a cooling water inlet of the secondary cooling mechanism, the cooling water inlet of the primary cooling mechanism is communicated with the circulating water tank, and a water outlet pipe of the secondary cooling mechanism is communicated with the circulating water tank.
The one-level cooling mechanism comprises a shell, and a material inlet and a material outlet which are arranged at the left end and the right end of the shell and are respectively communicated with the inside of the shell, two partition plates for partitioning the inside of the shell into three cavities are arranged in the shell, a cooling water inlet and a cooling water outlet which are communicated with the middle cavity are arranged on the shell, a plurality of transverse pipes for communicating the two cavities at the two ends are arranged in the middle cavity at equal intervals, and a plurality of cross flow plates are arranged at the top and the bottom of the middle cavity in a staggered manner.
Further, medicine filling mechanism includes the liquid filling machine main part and sets up the filling plummer in liquid filling machine main part bottom, the filling plummer is provided with a plurality of districts of placing that are used for placing the filling bottle, liquid filling machine main part top is provided with a plurality of filling heads with a plurality of filling bottle one-to-one, be provided with the sharp elevating system who drives all filling head monolithic lifting in the liquid filling machine main part, sharp elevating system is lift cylinder or lead screw elevating system.
An automated pharmaceutical production process comprising the steps of:
step 1: the material to be crushed enters a raw material crushing mechanism to be crushed, the crushed material is pushed into an anti-blocking conveying mechanism through a material pushing mechanism in the raw material crushing mechanism, and then is conveyed into a raw material drying mechanism through the anti-blocking conveying mechanism to be dried;
step 2: the materials dried by the raw material drying mechanism enter the composite dissolving tank through a horizontal conveying line and a packing auger feeding mechanism; smoke dust and waste gas generated when the raw material drying mechanism is used for drying are discharged into the atmosphere through the combined waste gas treatment system;
step 3, adding the materials dissolved in the composite dissolving tank and the materials or the medicaments to be added in the auxiliary material feeding system into a mixing and stirring tank, controlling the temperature of the mixing and stirring tank at a set temperature, stirring and mixing, and stopping stirring after the stirring is carried out for a set time;
step 4, the mixed materials pass through a filter system and then enter a circulating water cooling system for cooling treatment;
and 5, feeding the materials cooled by the circulating water cooling system into a medicine filling mechanism for filling treatment to finish the pharmaceutical process.
The invention has the following beneficial effects:
1. according to the invention, the raw material crushing mechanism, the anti-blocking conveying mechanism, the raw material drying mechanism, the horizontal conveying line, the auger feeding mechanism, the composite dissolving tank, the mixing and stirring tank, the filter and the medicine filling mechanism are sequentially connected according to the preparation flow, so that the production line is a continuous production process, has the advantages of high working efficiency and high automation degree, and simultaneously does not need to arrange a turnover device or manually turnover between the processes compared with the intermittent multi-process mixing production of the conventional independent production equipment, thereby effectively avoiding the situation that containers and powder are exposed in the working environment for many times, and avoiding the situation that the raw materials are exposed in the air to generate secondary pollution.
2. In the scheme, waste gas outlets generated by the raw material drying mechanism, the composite dissolving tank and the mixing and stirring tank are connected with a combined waste gas treatment system, and the combined waste gas treatment system comprises an adjustable adsorption mechanism, a high-efficiency filtering mechanism and an air draft mechanism which are sequentially arranged; after multi-stage treatment, the toxic and harmful substances in the waste gas are basically treated, and the gas which meets the emission standard is discharged into the atmosphere.
3. The inside pushing equipment that pushes the material after smashing to the discharge gate position that is provided with of ejection of compact intracavity in the broken mechanism of raw materials, the discharge gate one side is kept away from at ejection of compact intracavity top is provided with elasticity guide subassembly, and elasticity guide subassembly and pushing equipment's setting can make to be pushed as far as by broken material and pour out the material mouth, effectively avoids the export to block up.
4. The shell of the first-level cooling mechanism is internally provided with two partition plates which divide the interior of the shell into three cavities, the shell is provided with a cooling water inlet and a cooling water outlet which are communicated with the middle cavity, a plurality of transverse pipes which are communicated with the two cavities at two ends are arranged in the middle cavity at equal intervals, the top and the bottom of the middle cavity are provided with a plurality of cross flow plates in a staggered manner, the design of the cross flow plate structure can increase the path of the cooling water and the cooling effect, and the number of the cross flow plates can be designed according to the requirement.
5. The adjustable adsorption assembly comprises a connecting rod, a movable connecting rod and a plurality of adsorption blocks, wherein two ends of the connecting rod are fixed in the adsorption shell, two ends of the movable connecting rod are free, the adsorption blocks are arranged in a stacked mode, the same side of each adsorption block is hinged with the connecting rod at equal intervals, the other side of each adsorption block is hinged with the movable connecting rod at equal intervals, a driving mechanism for driving the adsorption block at the bottommost part to rotate is arranged at the bottom of the adsorption shell, and the driving mechanism is a driving air cylinder; this is a linkage structure, and actuating mechanism drives the rotation of the last piece of absorption piece, then can drive other absorption pieces through movable connecting rod and link together rotatoryly, and all absorption pieces can rotate to suitable angle simultaneously, and the design of this kind of structure probably increases the adsorption effect according to the rotation angle of waste gas quality control absorption piece.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural view of a material crushing mechanism;
FIG. 3 is a schematic structural diagram of an adjustable adsorption mechanism;
FIG. 4 is a schematic diagram of the structure of a 4-2-high efficiency filter mechanism;
FIG. 5 is a schematic structural view of a mixing and stirring tank;
FIG. 6 is a schematic structural view of a circulating water cooling system;
FIG. 7 is a schematic structural view of a drug filling mechanism;
FIG. 8 is a schematic view of an adjustable adsorption assembly;
reference numerals:
1-raw material crushing mechanism 1-1-feeding port, 1-2-crushing disc, 1-3-crushing cavity, 1-4-main crushing tooth, 1-5-auxiliary crushing tooth, 1-6-, 1-7-discharging port, 1-8-special-shaped material pushing plate, 1-9-linear driving mechanism, 1-10-elastic supporting mechanism and 1-11-inclined material guide plate;
2-anti-blocking conveying mechanism;
3-a raw material drying mechanism;
4-combined waste gas treatment system, 4-1-adjustable adsorption mechanism, 4-1.1-adjustable adsorption component, 4-1.2-activated carbon adsorption block, 4-2-high efficiency filter mechanism, 4-2.1-primary effect filter mechanism, 4-2.2-intermediate effect filter mechanism, 4-2.3-high efficiency filter mechanism;
5-horizontal conveying line;
6-auger feeding mechanism;
7-a composite dissolving tank;
8-mixing and stirring tank, 8-1-supporting foot stool, 8-2-mixing tank body, 8-3-heat preservation shell, 8-4-inspection hole and 8-5-composite stirring component;
9-an auxiliary material feeding system;
10-a filter;
11-a circulating water cooling system, 11-1-a primary cooling mechanism, 11-2-a secondary cooling mechanism and 11-3-a circulating water tank;
12-a medicine filling mechanism, 12-1-a filling bearing table, 12-2-a filling machine main body, 12-3-a linear lifting mechanism and 12-4-a filling head.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
In the description of the embodiments of the present invention, it should be noted that the terms "inside", "outside", "upper", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships conventionally arranged when products of the present invention are used, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements indicated must have specific orientations, be constructed in specific orientations, and operated, and thus, cannot be construed as limiting the present invention.
Example 1
As shown in fig. 1 to 8, this embodiment provides an automated pharmaceutical production line and process, which comprises a raw material crushing mechanism 1, an anti-blocking conveying mechanism 2, a raw material drying mechanism 3, a horizontal conveying line 5, a packing auger feeding mechanism 6, a composite dissolving tank 7, a mixing stirring tank 8, a filter 10 and a drug filling mechanism 12 which are sequentially connected according to a preparation process, wherein the raw material drying mechanism 3 comprises a waste gas outlet, the waste gas outlet is connected with a combined waste gas treatment system 4, the waste gas outlets of the composite dissolving tank 7 and the mixing stirring tank 8 are communicated with an inlet of the combined waste gas treatment system 4 through a pipeline, the combined waste gas treatment system 4 comprises an adjustable adsorption mechanism 4-1, a high-efficiency filtering mechanism 4-2 and an air draft mechanism which are sequentially arranged, a circulating water cooling system 11 is arranged between the filter 10 and the drug filling mechanism 12, a feed inlet of the mixing stirring tank 8 is further provided with an auxiliary material feeding system 9, the raw material crushing mechanism 1 comprises crushing cavities 1-3 and discharging cavities 1-6 communicated through a filter screen, a feeding hole 1-1 is formed in the top of each crushing cavity 1-3, a discharging hole 1-7 convenient for discharging is formed in the bottom of the side wall of each discharging cavity 1-6, a material pushing mechanism for pushing crushed materials into the discharging hole 1-7 is arranged inside each discharging cavity 1-6, and an elastic material guiding assembly is arranged on one side, far away from the discharging hole 1-7, of the top of each discharging cavity 1-6.
In the scheme, waste gas outlets generated by the raw material drying mechanism, the composite dissolving tank and the mixing and stirring tank are connected with a combined waste gas treatment system, and the combined waste gas treatment system comprises an adjustable adsorption mechanism, a high-efficiency filtering mechanism and an air draft mechanism which are sequentially arranged; after multi-stage treatment, the toxic and harmful substances in the waste gas are basically treated, and the gas which meets the emission standard is discharged into the atmosphere.
The inside pushing equipment that pushes the material after smashing to the discharge gate position that is provided with of ejection of compact intracavity in the broken mechanism of raw materials, the discharge gate one side is kept away from at ejection of compact intracavity top is provided with elasticity guide subassembly, and elasticity guide subassembly and pushing equipment's setting can make to be pushed as far as by broken material and pour out the material mouth, effectively avoids the export to block up.
Example 2
The embodiment is further optimized on the basis of embodiment 1, and specifically comprises the following steps:
a crushing disc 1-2 is arranged in the crushing cavity 1-3, a plurality of main crushing teeth 1-4 are uniformly distributed on the circumference of the crushing disc 1-2, and a plurality of auxiliary crushing teeth 1-5 matched with the main crushing teeth 1-4 are arranged on the inner wall of the crushing cavity 1-3;
the elastic material guide assembly comprises inclined material guide plates 1-11 hinged to one side of the filtering screen, which is far away from the discharge port 1-7, and elastic support mechanisms 1-10 arranged in the discharge cavity 1-6 and connected with the inclined material guide plates 1-11, wherein the elastic support mechanisms 1-10 are support springs;
the material pushing mechanism comprises a special-shaped material pushing plate 1-8 capable of reciprocating at the bottom of the material discharging cavity 1-6 and a linear driving mechanism 1-9 for driving the special-shaped material pushing plate 1-8 to move, the linear driving mechanism 1-9 is a screw nut driving assembly or a linear driving cylinder, the special-shaped material pushing plate 1-8 comprises a vertical plate and a material pushing bottom plate, the vertical plate is vertically arranged, the material pushing bottom plate is arranged at the bottom of the vertical plate and attached to the bottom of the material discharging cavity 1-6, the upper surface of the material pushing bottom plate is obliquely arranged, the cross section of the material pushing bottom plate is in a right triangle shape, and two right-angled sides are respectively connected with the vertical plate and the bottom of the material discharging cavity 1-6.
The adjustable adsorption mechanism 4-1 comprises an adsorption shell, and an air inlet and an air outlet which are communicated with the interior of the adsorption shell, and an adjustable adsorption component 4-1.1 and a plurality of activated carbon adsorption blocks 4-1.2 which are arranged in parallel are sequentially arranged in the adsorption shell along the direction of air flow;
adsorption component 4-1.1 includes that both ends are fixed at the connecting rod in the adsorption casing, the movable connecting rod that both ends are free and the absorption piece that the polylith range upon range of setting, and all absorb the piece with all equidistant articulated with the connecting rod, all absorb the other one side of piece all equidistant articulated with the movable connecting rod, it is provided with the absorption piece pivoted actuating mechanism of drive bottommost to adsorb casing bottom, actuating mechanism for driving actuating cylinder.
This is a linkage structure, and actuating mechanism drives the rotation of the last piece of absorption piece, then can drive other absorption pieces through movable connecting rod and link together rotatoryly, and all absorption pieces can rotate to suitable angle simultaneously, and the design of this kind of structure probably increases the adsorption effect according to the rotation angle of waste gas quality control absorption piece.
The high-efficiency filtering mechanism 4-2 comprises a shell, and an air inlet and an air outlet which are arranged at two ends of the shell and communicated with the inside of the shell, wherein a primary filtering mechanism 4-2.1, a secondary filtering mechanism 4-2.2 and a high-efficiency filtering mechanism 4-2.3 are sequentially arranged in the shell from the air inlet end to the air outlet end, the primary filtering mechanism 4-2.1 and the high-efficiency filtering mechanism 4-2.3 are filtering nets, and the meshes of the filtering net of the primary filtering mechanism 4-2.1 are larger than those of the high-efficiency filtering mechanism 4-2.3.
The medium-efficiency filtering mechanism 4-2.2 comprises a filtering cavity arranged in the middle of the shell, the top of the filtering cavity, which is close to one side of the air inlet, is provided with a ventilation hole, the bottom of the filtering cavity, which is close to one side of the air outlet, is provided with a filtering net with the same multilayer structure, the filtering net in the filtering cavity is sequentially inclined from top to bottom, and the mesh diameter of the filtering net of the medium-efficiency filtering mechanism 4-2.2 is between that of the primary-efficiency filtering mechanism 4-2.1 and that of the filtering net of the high-efficiency filtering mechanism 4-2.3.
The mixing and stirring tank 8 comprises a mixing tank body 8-2, a feeding hole and a discharging hole which are communicated with the top and the bottom of the mixing tank body 8-2, the outer side of the mixing tank body 8-2 is sleeved with a heat insulation shell 8-3, the bottom of the outer side of the heat insulation shell 8-3 is provided with a supporting foot stand 8-1, the bottom of the supporting foot stand 8-1 is provided with a movable roller, the movable roller is provided with a brake component, a composite stirring component 8-5 is arranged in the mixing tank body 8-2, the composite stirring component 8-5 comprises a stirring shaft positioned in the mixing tank body 8-2 and a driving motor positioned at the outer top of the mixing tank body 8-2 and driving the stirring shaft to rotate, the stirring shaft is provided with a horizontal stirring component and a U-shaped stirring component, and the top of the mixing tank body 8-2 is provided with an access hole 8-4.
U type stirring subassembly includes the ascending U type puddler of opening, the end of (mixing) shaft and the bottom fixed connection in the U type puddler, U type puddler inboard and the outside are provided with boss and supplementary stirring piece respectively, and the boss is connected with the agitator shaft.
The auxiliary material feeding system 9 comprises a plurality of medicine adding tanks arranged in parallel, discharge ports of all the medicine adding tanks are connected with a feed port of the mixing tank body 8-2 through pipelines, and a discharge port of each medicine adding tank is provided with an electromagnetic valve.
The circulating water cooling system 11 comprises a primary cooling mechanism 11-1, a secondary cooling mechanism 11-2 and a circulating water tank 11-3, material pipelines of the primary cooling mechanism 11-1 and the secondary cooling mechanism 11-2 are communicated, a cooling water outlet of the primary cooling mechanism 11-1 is communicated with a cooling water inlet of the secondary cooling mechanism 11-2, a cooling water inlet of the primary cooling mechanism 11-1 is communicated with the circulating water tank 11-3, and a water outlet pipe of the secondary cooling mechanism 11-2 is communicated with the circulating water tank 11-3.
The first-stage cooling mechanism 11-1 comprises a shell, and a material inlet and a material outlet which are arranged at the left end and the right end of the shell and are respectively communicated with the inside of the shell, two partition plates for dividing the inside of the shell into three cavities are arranged in the shell, a cooling water inlet and a cooling water outlet which are communicated with a middle cavity are arranged on the shell, a plurality of transverse pipes for communicating two cavities at two ends are arranged in the middle cavity at equal intervals, and a plurality of cross flow plates are arranged at the top and the bottom of the middle cavity in a staggered manner.
The medicine filling mechanism 12 comprises a filling machine main body 12-2 and a filling bearing table 12-1 arranged at the bottom of the filling machine main body 12-2, wherein the filling bearing table 12-1 is provided with a plurality of placing areas for placing filling bottles, a plurality of filling heads 12-4 corresponding to the filling bottles one by one are arranged at the top of the filling machine main body 12-2, a linear lifting mechanism 12-3 for driving all the filling heads 12-4 to lift integrally is arranged on the filling machine main body 12-2, and the linear lifting mechanism 12-3 is a lifting cylinder or a screw rod lifting mechanism.
Example 3
An automated pharmaceutical production process using the automated pharmaceutical production line of embodiment 1, comprising the steps of:
step 1: the material to be crushed enters a raw material crushing mechanism to be crushed, the crushed material is pushed into an anti-blocking conveying mechanism through a material pushing mechanism in the raw material crushing mechanism, and then is conveyed into a raw material drying mechanism through the anti-blocking conveying mechanism to be dried;
step 2: the materials dried by the raw material drying mechanism enter the composite dissolving tank through a horizontal conveying line and a packing auger feeding mechanism; smoke dust and waste gas generated when the raw material drying mechanism is used for drying are discharged into the atmosphere through the combined waste gas treatment system;
step 3, adding the materials dissolved in the composite dissolving tank and the materials or the medicaments to be added in the auxiliary material feeding system into a mixing and stirring tank, controlling the temperature of the mixing and stirring tank at a set temperature, stirring and mixing, and stopping stirring after the stirring is carried out for a set time;
step 4, the mixed materials pass through a filter system and then enter a circulating water cooling system for cooling treatment;
and 5, feeding the materials cooled by the circulating water cooling system into a medicine filling mechanism for filling treatment to finish the pharmaceutical process.
The raw material crushing mechanism, the anti-blocking conveying mechanism, the raw material drying mechanism, the horizontal conveying line, the auger feeding mechanism, the composite dissolving tank, the mixing and stirring tank, the filter and the medicine filling mechanism are sequentially connected according to the preparation flow, the continuous production process is realized, the advantages of high working efficiency and high automation degree are achieved, and compared with the intermittent multi-process mixing manufacturing of the existing independent production equipment, the production line does not need to be provided with a turnover device or manual turnover among the processes, so that the situation that containers and powder are exposed in the working environment for many times is effectively avoided, the raw materials are prevented from being exposed in the air, and secondary pollution is generated.
Claims (10)
1. An automatic pharmaceutical production line is characterized by comprising a raw material crushing mechanism (1), an anti-blocking conveying mechanism (2), a raw material drying mechanism (3), a horizontal conveying line (5), a packing auger feeding mechanism (6), a composite dissolving tank (7), a mixing stirring tank (8), a filter (10) and a medicine filling mechanism (12) which are sequentially connected according to a preparation flow, wherein the raw material drying mechanism (3) comprises a waste gas outlet which is connected with a combined waste gas treatment system (4), the waste gas outlets of the composite dissolving tank (7) and the mixing stirring tank (8) are communicated with an inlet of the combined waste gas treatment system (4) through a pipeline, the combined waste gas treatment system (4) comprises an adjustable adsorption mechanism (4-1), a high-efficiency filtering mechanism (4-2) and an air draft mechanism which are sequentially arranged, and a circulating water cooling system (11) is arranged between the filter (10) and the medicine filling mechanism (12), the feed inlet of mixing and stirring jar (8) still be provided with auxiliary material feeding system (9), broken mechanism of raw materials (1) is including broken chamber (1-3) and play material chamber (1-6) through the filter screen intercommunication, broken chamber (1-3) top is provided with the feed inlet, goes out material chamber (1-6) lateral wall bottom and is provided with discharge gate (1-7) that make things convenient for the ejection of compact, it pushes the pushing equipment of discharge gate (1-7) position to smash the back material to go out material chamber (1-6) inside be provided with, it is provided with elasticity guide subassembly to keep away from discharge gate (1-7) one side at the top in play material chamber (1-6).
2. The automated pharmaceutical production line according to claim 1, wherein the elastic material guiding assembly comprises an inclined material guiding plate (1-11) hinged to one side of the filtering screen, which is far away from the material outlet (1-7), and an elastic supporting mechanism (1-10) arranged in the material outlet cavity (1-6) and connected with the inclined material guiding plate (1-11);
the material pushing mechanism comprises special-shaped material pushing plates (1-8) capable of reciprocating at the bottoms of the discharging cavities (1-6) and linear driving mechanisms (1-9) for driving the special-shaped material pushing plates (1-8) to move, the special-shaped material pushing plates (1-8) comprise vertical plates which are vertically arranged and material pushing bottom plates which are arranged at the bottoms of the vertical plates and attached to the bottoms of the discharging cavities (1-6), the upper surfaces of the material pushing bottom plates are obliquely arranged, the cross sections of the material pushing bottom plates are right-angled triangles, and two right-angled edges are respectively connected with the vertical plates and the bottoms of the discharging cavities (1-6).
3. The automated pharmaceutical production line according to claim 1, wherein the adjustable adsorption mechanism (4-1) comprises an adsorption housing, and an air inlet and an air outlet which are communicated with the interior of the adsorption housing, and the adsorption housing is internally provided with an adjustable adsorption assembly (4-1.1) and a plurality of activated carbon adsorption blocks (4-1.2) which are arranged in parallel along the air flow direction;
adsorption component (4-1.1) including both ends fix the adsorption piece that the connecting rod in the adsorption casing, the movable connecting rod that both ends are free and the range upon range of setting of polylith, all adsorb the piece with all equidistant articulated with the connecting rod, all adsorb other one side of piece all equidistant articulated with the movable connecting rod, it is provided with the adsorption piece pivoted actuating mechanism of drive bottommost to adsorb casing bottom, actuating mechanism for driving actuating cylinder.
4. The automated pharmaceutical production line according to claim 1, wherein the high efficiency filter mechanism (4-2) comprises a housing, and an air inlet and an air outlet which are arranged at two ends of the housing and are communicated with the inside of the housing, a primary filter mechanism (4-2.1), a secondary filter mechanism (4-2.2) and a high efficiency filter mechanism (4-2.3) are sequentially arranged in the housing from the air inlet end to the air outlet end, the primary filter mechanism (4-2.1) and the high efficiency filter mechanism (4-2.3) are filter screens, and the mesh of the filter screen of the primary filter mechanism (4-2.1) is larger than that of the high efficiency filter mechanism (4-2.3).
5. The automated pharmaceutical production line according to claim 4, wherein the middle-effect filtering mechanism (4-2.2) comprises a filtering cavity arranged in the middle of the housing, the top of the filtering cavity near the air inlet is provided with a vent hole, the bottom of the filtering cavity near the air outlet is provided with a vent hole, and multiple layers of filtering nets with the same structure are sequentially arranged in the filtering cavity in an inclined manner from top to bottom.
6. The automated pharmaceutical production line according to claim 1, wherein the mixing and stirring tank (8) comprises a mixing tank body (8-2) and a feeding port and a discharging port which are communicated with the top and the bottom of the mixing tank body (8-2), the outer side of the mixing tank body (8-2) is sleeved with a heat-insulating shell (8-3), and a composite stirring assembly (8-5) is arranged inside the mixing tank body (8-2).
7. The automated pharmaceutical production line according to claim 6, wherein the auxiliary material feeding system (9) comprises a plurality of dosing tanks arranged in parallel, discharge ports of all the dosing tanks are connected with the feed port of the mixing tank body (8-2) through pipelines, and a discharge port of each dosing tank is provided with an electromagnetic valve.
8. The automated pharmaceutical production line according to claim 1, wherein the circulating water cooling system (11) comprises a primary cooling mechanism (11-1), a secondary cooling mechanism (11-2) and a circulating water tank (11-3), the material pipelines of the primary cooling mechanism (11-1) and the secondary cooling mechanism (11-2) are communicated, the cooling water outlet of the primary cooling mechanism (11-1) is communicated with the cooling water inlet of the secondary cooling mechanism (11-2), the cooling water inlet of the primary cooling mechanism (11-1) is communicated with the circulating water tank (11-3), and the water outlet pipe of the secondary cooling mechanism (11-2) is communicated with the circulating water tank (11-3).
The first-stage cooling mechanism (11-1) comprises a shell, and a material inlet and a material outlet which are arranged at the left end and the right end of the shell and are respectively communicated with the inside of the shell, two partition plates for dividing the inside of the shell into three cavities are arranged in the shell, a cooling water inlet and a cooling water outlet which are communicated with a middle cavity are arranged on the shell, a plurality of transverse pipes which are communicated with the two cavities at the two ends are arranged in the middle cavity at equal intervals, and a plurality of cross flow plates are arranged at the top and the bottom of the middle cavity in a staggered manner.
9. The automated pharmaceutical production line according to claim 1, wherein the drug filling mechanism (12) comprises a filling machine main body (12-2) and a filling carrier (12-1) disposed at the bottom of the filling machine main body (12-2), the filling carrier (12-1) is provided with a plurality of placing areas for placing filling bottles, the top of the filling machine main body (12-2) is provided with a plurality of filling heads corresponding to the plurality of filling bottles one by one, the filling machine main body (12-2) is provided with a linear lifting mechanism (12-3) for driving all the filling heads to lift integrally, and the linear lifting mechanism (12-3) is a lifting cylinder or a screw rod lifting mechanism.
10. An automated pharmaceutical manufacturing process using an automated pharmaceutical manufacturing line according to claim 1, comprising the steps of:
step 1: the material to be crushed enters a raw material crushing mechanism to be crushed, the crushed material is pushed into an anti-blocking conveying mechanism through a material pushing mechanism in the raw material crushing mechanism, and then is conveyed into a raw material drying mechanism through the anti-blocking conveying mechanism to be dried;
step 2: the materials dried by the raw material drying mechanism enter the composite dissolving tank through a horizontal conveying line and a packing auger feeding mechanism; smoke dust and waste gas generated when the raw material drying mechanism is used for drying are discharged into the atmosphere through the combined waste gas treatment system;
step 3, adding the materials dissolved in the composite dissolving tank and the materials or the medicaments to be added in the auxiliary material feeding system into a mixing and stirring tank, controlling the temperature of the mixing and stirring tank at a set temperature, stirring and mixing, and stopping stirring after the stirring is carried out for a set time;
step 4, the mixed materials pass through a filter system and then enter a circulating water cooling system for cooling treatment;
and 5, feeding the materials cooled by the circulating water cooling system into a medicine filling mechanism for filling treatment to finish the pharmaceutical process.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113751168A (en) * | 2021-08-24 | 2021-12-07 | 重庆工贸职业技术学院 | System for realizing preparation, extraction, analysis and detection of pharmaceutical preparation |
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