CN113226157A - 用于原位或体外多参数细胞和亚细胞成像数据的计算系统病理学空间分析平台 - Google Patents
用于原位或体外多参数细胞和亚细胞成像数据的计算系统病理学空间分析平台 Download PDFInfo
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- CN113226157A CN113226157A CN201980084101.2A CN201980084101A CN113226157A CN 113226157 A CN113226157 A CN 113226157A CN 201980084101 A CN201980084101 A CN 201980084101A CN 113226157 A CN113226157 A CN 113226157A
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Applications Claiming Priority (3)
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US201862781759P | 2018-12-19 | 2018-12-19 | |
US62/781,759 | 2018-12-19 | ||
PCT/US2019/066446 WO2020131658A1 (fr) | 2018-12-19 | 2019-12-16 | Plateforme d'analyse spatiale de pathologie à systèmes de calcul pour données d'imagerie cellulaires et infracellulaires à paramètres multiples in situ ou in vitro |
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CN113226157A true CN113226157A (zh) | 2021-08-06 |
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US (2) | US11983943B2 (fr) |
EP (1) | EP3897360A4 (fr) |
JP (2) | JP7420401B2 (fr) |
CN (1) | CN113226157A (fr) |
CA (1) | CA3123641A1 (fr) |
WO (1) | WO2020131658A1 (fr) |
Families Citing this family (1)
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EP4165652A4 (fr) * | 2020-06-15 | 2024-06-12 | Bragg Analytics, Inc. | Système de diagnostic in vitro global basé sur la diffraction |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180204085A1 (en) * | 2015-06-11 | 2018-07-19 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Systems and methods for finding regions of interest in hematoxylin and eosin (h&e) stained tissue images and quantifying intratumor cellular spatial heterogeneity in multiplexed/hyperplexed fluorescence tissue images |
US20180239949A1 (en) * | 2015-02-23 | 2018-08-23 | Cellanyx Diagnostics, Llc | Cell imaging and analysis to differentiate clinically relevant sub-populations of cells |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005111905A2 (fr) | 2004-05-17 | 2005-11-24 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Prevision du comportement dynamique d'un systeme biologique |
CA2679436C (fr) | 2007-04-05 | 2018-10-23 | Aureon Laboratories, Inc. | Systemes et procedes destines a traiter, diagnostiquer et prevoir la survenue d'un etat medical |
WO2009046544A1 (fr) * | 2007-10-11 | 2009-04-16 | British Columbia Cancer Agency Branch | Systèmes et procédés pour une caractérisation automatisée d'une hétérogénéité génétique dans des échantillons de tissu |
CA3120217A1 (fr) * | 2011-04-29 | 2012-11-01 | Cancer Prevention And Cure, Ltd. | Procedes d'identification et de diagnostic de maladies pulmonaires a l'aide de systemes de classification et leurs kits |
US9370304B2 (en) * | 2012-06-06 | 2016-06-21 | The Regents Of The University Of Michigan | Subvolume identification for prediction of treatment outcome |
US8873827B2 (en) * | 2012-06-29 | 2014-10-28 | General Electric Company | Determination of spatial proximity between features of interest in biological tissue |
WO2014102130A1 (fr) * | 2012-12-28 | 2014-07-03 | Ventana Medical Systems, Inc. | Analyse d'image pour pronostic de cancer du sein |
US20140372450A1 (en) * | 2013-06-14 | 2014-12-18 | General Electric Company | Methods of viewing and analyzing high content biological data |
US10049447B2 (en) * | 2013-11-06 | 2018-08-14 | H. Lee Moffitt Cancer Center and Research Insititute, Inc. | Pathology case review, analysis and prediction |
WO2015089434A1 (fr) * | 2013-12-12 | 2015-06-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Segmentation de noyaux de cellules épithéliales automatisée pour des algorithmes de détection de maladie computationnels |
US9483685B2 (en) * | 2014-04-28 | 2016-11-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | System and method for automated identification of abnormal ciliary motion |
US10176408B2 (en) * | 2015-08-14 | 2019-01-08 | Elucid Bioimaging Inc. | Systems and methods for analyzing pathologies utilizing quantitative imaging |
US9613254B1 (en) * | 2015-09-30 | 2017-04-04 | General Electric Company | Quantitative in situ characterization of heterogeneity in biological samples |
NL2016281B1 (en) | 2016-02-18 | 2017-08-24 | Perkinelmer Health Sciences B V | Means and methods for spheroid cell culturing and analysis. |
JP7042252B2 (ja) | 2016-07-27 | 2022-03-25 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 架橋密度の勾配を有するポリマー足場を作出するための方法 |
EP3721406B1 (fr) * | 2017-12-05 | 2024-01-24 | Ventana Medical Systems, Inc. | Procédé de calcul d'hétérogénéité spatiale et entre marqueurs de tumeur |
US11954593B2 (en) * | 2018-06-22 | 2024-04-09 | H-Labs Gmbh | Method to determine a degree of abnormality, a respective computer readable medium and a distributed cancer analysis system |
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2019
- 2019-12-16 JP JP2021535632A patent/JP7420401B2/ja active Active
- 2019-12-16 CA CA3123641A patent/CA3123641A1/fr active Pending
- 2019-12-16 WO PCT/US2019/066446 patent/WO2020131658A1/fr unknown
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180239949A1 (en) * | 2015-02-23 | 2018-08-23 | Cellanyx Diagnostics, Llc | Cell imaging and analysis to differentiate clinically relevant sub-populations of cells |
US20180204085A1 (en) * | 2015-06-11 | 2018-07-19 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Systems and methods for finding regions of interest in hematoxylin and eosin (h&e) stained tissue images and quantifying intratumor cellular spatial heterogeneity in multiplexed/hyperplexed fluorescence tissue images |
Non-Patent Citations (2)
Title |
---|
BÜLENT YENER,等: "Cell-graphs: image-driven modeling of structure-function relationship", COMMUNICATIONS OF THE ACM, vol. 60, no. 1, pages 74 - 84 * |
DANIEL M. SPAGNOLO ,等: "Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images", CANCER, vol. 21, no. 77, pages 1 - 3 * |
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Publication number | Publication date |
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JP2022514373A (ja) | 2022-02-10 |
US20240185626A1 (en) | 2024-06-06 |
EP3897360A4 (fr) | 2022-03-16 |
JP2024038186A (ja) | 2024-03-19 |
US20220044401A1 (en) | 2022-02-10 |
JP7420401B2 (ja) | 2024-01-23 |
CA3123641A1 (fr) | 2020-06-25 |
EP3897360A1 (fr) | 2021-10-27 |
US11983943B2 (en) | 2024-05-14 |
WO2020131658A1 (fr) | 2020-06-25 |
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