CN113209038A - Preparation method and application of soft capsule film coating premix - Google Patents
Preparation method and application of soft capsule film coating premix Download PDFInfo
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- CN113209038A CN113209038A CN202110424712.6A CN202110424712A CN113209038A CN 113209038 A CN113209038 A CN 113209038A CN 202110424712 A CN202110424712 A CN 202110424712A CN 113209038 A CN113209038 A CN 113209038A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/834—Mixing in several steps, e.g. successive steps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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Abstract
A preparation method and application of a soft capsule film coating premix comprises the following steps: 1) weighing and preparing materials; 2) dispersing; 3) totally mixing; 4) and packaging and warehousing, preparing the film coating premix into coating liquid, and spraying the coating liquid outside the pill to form a layer of functional film. The film coating premix prepared by the invention adopts the optimal dispersion time, ensures that all materials are fully and uniformly mixed and dispersed, the fineness meets the requirement of the optimal mesh number, and the hopper mixing agent mixes the materials dispersed by the wet mixing granulator for 60 minutes at fixed points, thereby ensuring the consistency of the same batch of products, improving the stability of the products and further ensuring the coating to achieve the optimal effect.
Description
Technical Field
The invention relates to the technical field of pharmaceutical excipients, in particular to a preparation method and application of a soft capsule coating premix.
Background
The soft capsule preparation is commonly used in medicines or health-care foods, the market demand of health-care products, particularly soft capsules, is getting bigger, the requirement on the quality of the soft capsule is getting higher, and the coating plays a great role in improving the quality of the soft capsule.
The soft capsule is prepared from gelatin, glycerol or other suitable medicinal adjuvants, and can be made into capsule or capsule. The soft capsule preparation is mostly used for water insolubility; the liquid oily substance can be directly sealed into a capsule, the preparation is a new preparation formulation, the soft capsule preparation has many advantages, and can solve the problems that some traditional Chinese medicine preparations cannot solve, but also has some problems, such as difficult storage, easy caking, adhesion, deformation, capsule skin breakage, oil leakage, seam cracking and the like in the places where the soft capsule meets damp and heat.
Disclosure of Invention
The invention provides a preparation method and preparation of a soft capsule film coating premix.
The film coating premix is prepared by physically mixing the material components of a film forming agent, a plasticizer, a coloring agent and the like, and is prepared by adding a solvent to prepare a suspension which is sprayed outside the pill to form a layer of functional film.
The technical scheme adopted by the invention is as follows:
a preparation method of a soft capsule film coating premix comprises the following steps:
1) weighing and preparing materials: accurately weighing the quantities of the components of the film forming agent, the plasticizer and the colorant by using an electronic balance and an electronic platform scale according to a production instruction, storing the components in a low-density polyethylene bag, marking, and fastening a bag opening;
2) dispersing: unpacking the to-be-dispersed materials, pouring the to-be-dispersed materials into a pot of a wet mixing granulator, sequentially opening keys of a stirring I, a stirring II, a cutter I and a cutter II every 10 seconds, mixing and dispersing for 15 minutes, opening a pot cover of the wet mixing granulator, covering the pot cover after checking the mixing and dispersing conditions, dispersing for 15 minutes again, and discharging after the dispersing is finished;
3) total mixing: untie the bag mouth of the mixed material, pour into the hopper blender, set for mixing time 60 minutes, start to start it to stop automatically, open the discharge port, press "discharging" button, discharge to the low density polyethylene bag, until finishing discharging;
4) packaging and warehousing: after the inspection is finished, the double-layer low-density polyethylene bag and the paper tube are adopted to carry out inner package and outer package in sequence, and finally, the materials are stored in a storage area.
In the dispersing step, a color difference meter method is adopted for monitoring the color of the dispersed material.
The rotating speed operation parameter set by the mixing granulator in the dispersing step is 300 revolutions per minute.
The application of the soft capsule film coating premix comprises the following steps:
a. dosage of the film coating premix: the actual weight gain is determined by the result of the disintegration time limit detection of the coated pill core in the coating process;
b. calculating the dosage of the film coating premix; the mass ratio of the film coating premix to the coating liquid is solid content, the mass of the pill core to be coated is determined, theoretical weight gain is set, and the dosage of the solvent and the film coating premix is calculated;
c. preparing a coating solution:
the size of the dosing tank is as follows: the height-diameter ratio of the mixing tank is 1.0-2.0, the volume of the container is 1.5-2.0 times of the coating liquid amount, and the diameter of the stirring paddle is about 1/3 of the mixing tank;
pouring the prepared solvent into a mixing tank with stirring, and starting stirring;
thirdly, slowly adding the weighed film coating premix to the vortex of the stirred solvent in a flowing manner, and finishing the adding within 3-5 minutes;
d. basic parameters of the film coating machine:
e. adjusting the spray gun:
the spray guns are vertical to the pill bed and are 20-30 cm apart, the sector of the coating liquid sprayed out of the spray nozzles is arranged in the upper middle part of the pill bed, two adjusting bolts are arranged on the spray guns, the atomization adjustment can be adjusted until the atomization surfaces of the three spray guns are not overlapped, the spray amount adjustment can be adjusted according to the actual situation in the coating process, so that the spray amount reaches the maximum under certain rotating speed, air inlet and outlet amount and pill core temperature, namely, the hand feeling feels that the surface of the pill core which is just sprayed with the coating liquid has a damp feeling but does not generate a pill sticking phenomenon;
f. controlling various parameters in the coating process:
after the preparation work is done, opening homogenate and guniting to start coating:
rotation speed:
setting a medium rotating speed of 2-3 rpm for avoiding the adhesion of the pill cores when coating is started, and after the coating is carried out for 20-30 minutes, increasing the rotating speed by protecting a coating layer, wherein the final coating stage can reach 6-10 rpm;
② temperature of the pill core:
controlling the temperature of the pellet core at 35-40 ℃ in the coating process;
regulating atomization:
in the early coating process, the atomization is adjusted to be maximum, and in the later period, the atomization is adjusted to be small for increasing the brightness of the color;
controlling the spraying amount:
in the whole coating process, the spraying amount is the maximum amount under the set parameters, namely under the condition that the rotating speed and the temperature of the pill cores are determined, the pill cores which are just sprayed with the coating liquid are felt to be moist by hands but not to be sticky, and the pill cores at the bottommost part of the tablet bed are basically dry;
g. cleaning the coating machine:
after coating, washing with ethanol, sodium carbonate or sodium hydroxide alkaline solution.
And c, uniformly stirring the coating solution in the step c for not less than 45 minutes to fully dissolve and disperse the coating solution in the solvent.
And f, increasing the rotating speed of a coating machine when the coating liquid with poor flowability is used for coating.
The invention has the beneficial effects that: the film coating premix prepared by the invention adopts the optimal dispersion time, ensures that all materials are fully and uniformly mixed and dispersed, the fineness meets the requirement of the optimal mesh number, and the hopper mixing agent mixes the materials dispersed by the wet mixing granulator for 60 minutes at fixed points, thereby ensuring the consistency of the same batch of products, improving the stability of the products and further ensuring the coating to achieve the optimal effect.
Drawings
FIG. 1 is a diagram showing the coating inspection of the coated premix of the present invention after 20min of total mixing.
FIG. 2 is a diagram showing the coating inspection of the coated premix of the present invention after 40min of total mixing.
FIG. 3 is a diagram showing the coating inspection of the coated premix of the present invention after mixing for 60 min.
FIG. 4 is a diagram showing the coating inspection of the coated premix of the present invention after total mixing for 70 min.
FIG. 5 is a graph showing the coating dissolution test performed after the coating premix of the present invention is mixed for 20 min.
FIG. 6 is a graph showing the coating dissolution test performed after the coating premix of the present invention is mixed for 40 min.
FIG. 7 is a graph showing the coating dissolution test performed after the coating premix of the present invention is mixed for 60 min.
FIG. 8 is a graph showing the coating dissolution test performed after the coating premix of the present invention is mixed for 70 min.
Detailed Description
A preparation method of a soft capsule film coating premix comprises the following steps:
1) weighing and preparing materials: accurately weighing the quantities of the components of the film forming agent, the plasticizer and the colorant by using an electronic balance and an electronic platform scale according to a production instruction, storing the components in a low-density polyethylene bag, marking, and fastening a bag opening;
2) dispersing: unpacking a bag opening of a material to be dispersed, pouring the material into a pot of a wet mixing granulation machine, wherein the model of the wet mixing granulation machine is HLSG-220B, sequentially opening keys of a stirring I, a stirring II, a cutter I and a cutter II every 10 seconds, mixing and dispersing for 15 minutes, opening a pot cover of the wet mixing granulation machine, after checking the mixing and dispersing conditions, covering the pot cover, dispersing for 15 minutes again, setting the rotation number operation parameter of the mixing granulation machine in the dispersing step to be 300 revolutions per minute, and discharging after the dispersing is finished;
3) total mixing: unpacking the bag mouth of the material to be mixed, pouring the material into a hopper mixer, setting the type of the hopper mixer to be HZD-2000, setting the mixing time to be 60 minutes, starting the machine to be automatically stopped, starting a discharge port, pressing a discharge button, discharging the material into a low-density polyethylene bag until the discharge is finished;
4) packaging and warehousing: after the inspection is finished, the double-layer low-density polyethylene bag and the paper tube are adopted to carry out inner package and outer package in sequence, and finally, the materials are stored in a storage area.
In the dispersing step, a color difference meter method is adopted for monitoring the color of the dispersed material.
The rotating speed operation parameter set by the mixing granulator in the dispersing step is 300 revolutions per minute.
The application of the soft capsule film coating premix comprises the following steps:
a. dosage of the film coating premix: the actual weight gain is determined by the result of the disintegration time limit detection of the coated pill core in the coating process;
b. calculating the dosage of the film coating premix; the mass ratio of the film coating premix to the coating liquid is solid content, the mass of the pill core to be coated is determined, theoretical weight gain is set, and the dosage of the solvent and the film coating premix is calculated;
for example, the theoretical weight gain is 2.0 percent, the solvent is 90 percent ethanol, the solid content is 10 percent, and the core of the pellet to be coated is 100kg
The dosage of the film coating premix is 100kg multiplied by 2 percent to 2.00kg
90% ethanol 2.0 ÷ 10% -2.0 ═ 18.00kg
95% ethanol dosage is 90% ethanol dosage x 90% ÷ 95% ═ 17.05kg
The amount of purified water is 18-17.05-0.95 kg
The solid content of the enteric JHPS type film coating premix is generally 8.0 to 14.0 percent,
note that when organic components are used as the solvent, the coating machine needs to take explosion-proof measures,
c. preparing a coating solution:
the size of the dosing tank is as follows: the height-diameter ratio of the mixing tank is 1.0-2.0, the volume of the container is 1.5-2.0 times of the coating liquid amount, and the diameter of the stirring paddle is about 1/3 of the mixing tank;
pouring the prepared solvent into a mixing tank with stirring, and starting stirring;
thirdly, slowly adding the weighed film coating premix to the vortex of the stirred solvent in a flowing manner, and finishing the adding within 3-5 minutes;
d. basic parameters of the film coating machine:
e. adjusting the spray gun:
the spray guns are vertical to the pill bed and are 20-30 cm apart, the sector of the coating liquid sprayed out of the spray nozzles is arranged in the upper middle part of the pill bed, two adjusting bolts are arranged on the spray guns, the atomization adjustment can be adjusted until the atomization surfaces of the three spray guns are not overlapped, the spray amount adjustment can be adjusted according to the actual situation in the coating process, so that the spray amount reaches the maximum under certain rotating speed, air inlet and outlet amount and pill core temperature, namely, the hand feeling feels that the surface of the pill core which is just sprayed with the coating liquid has a damp feeling but does not generate a pill sticking phenomenon;
f. controlling various parameters in the coating process:
after the preparation is completed, the homogenization and guniting can be started to coat:
rotation speed:
setting a medium rotating speed of 2-3 rpm for avoiding the adhesion of the pill cores when coating is started, and after the coating is carried out for 20-30 minutes, increasing the rotating speed by protecting a coating layer, wherein the final coating stage can reach 6-10 rpm;
② temperature of the pill core:
the temperature of the pill core is controlled to be 35-40 ℃ in the coating process, and the early temperature can be properly higher than the later temperature; the temperature is the temperature of the pill core, the air exhaust temperature is generally 1-5 ℃ higher than the temperature of the pill core, but depends on the heating temperature and the air intake and exhaust amount,
regulating atomization:
in the early coating process, the atomization is adjusted to be maximum, and the brightness of the added color can be properly adjusted to be smaller in the later period;
controlling the spraying amount:
in the whole coating process, the spraying amount is the maximum amount under the set parameters, namely under the condition that the rotating speed and the temperature of the pill cores are determined, the pill cores which are just sprayed with the coating liquid are felt to be moist by hands but not to be sticky, and the pill cores at the bottommost part of the tablet bed are basically dry;
g. cleaning the coating machine:
after coating, washing with ethanol, sodium carbonate or sodium hydroxide alkaline solution.
In the cleaning process of the infusion pipeline and the spray gun, the coating liquid is not remained as much as possible, and the infusion pipeline and the spray gun are thoroughly cleaned after being soaked by the corresponding solution, so that the infusion pipeline is ensured to be free of the residual coating liquid; the spray gun must not be cleaned by hard objects, and a soft brush or a swab can be used to avoid damaging precision parts of the spray gun and influencing the spraying or atomizing effect.
And c, uniformly stirring the coating solution in the step c for not less than 45 minutes to fully dissolve and disperse the coating solution in the solvent.
And f, increasing the rotating speed of a coating machine when the coating liquid with poor flowability is used for coating.
The stirring and cutting of the wet mixing granulator were run simultaneously, and the coating effect was verified by fixed point sampling tests on the material for different dispersion times of 20min, 40min, 60min and 70min, as shown in table 1.
TABLE 1
In the attached drawings, 20min total mixing time is adopted, a large number of color dots exist in the coating, in the attached drawings, 40min total mixing time is adopted, in the attached drawings, a small number of color dots exist in the coating, in the attached drawings, 60min total mixing time is shown in fig. 3, no color dots exist in the coating, in fig. 4, after 70min total mixing time, color dots occasionally exist in the coating, in fig. 5-8, the dissolution effect of each coating is observed, 60min dissolution is most uniform and complete, all the attached drawings are combined with table 1, the optimal dispersion time of a wet mixing granulator is 60min when the film coating premix is prepared, the full uniform mixing of all materials is ensured, the fixed-point mixing is 60min, the consistency of the products in the same batch is ensured, the stability of the products is ensured, and the optimal effect of the coating is further ensured.
The embodiments of the present invention have been described in detail, but the description is only for the preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.
Claims (6)
1. A preparation method of a soft capsule film coating premix is characterized by comprising the following steps:
1) weighing and preparing materials: accurately weighing the quantities of the components of the film forming agent, the plasticizer and the colorant by using an electronic balance and an electronic platform scale according to a production instruction, storing the components in a low-density polyethylene bag, marking, and fastening a bag opening;
2) dispersing: unpacking the to-be-dispersed materials, pouring the to-be-dispersed materials into a pot of a wet mixing granulator, sequentially opening keys of a stirring I, a stirring II, a cutter I and a cutter II every 10 seconds, mixing and dispersing for 15 minutes, opening a pot cover of the wet mixing granulator, covering the pot cover after checking the mixing and dispersing conditions, dispersing for 15 minutes again, and discharging after the dispersing is finished;
3) total mixing: untie the bag mouth of the mixed material, pour into the hopper blender, set for mixing time 60 minutes, start to start it to stop automatically, open the discharge port, press "discharging" button, discharge to the low density polyethylene bag, until finishing discharging;
4) packaging and warehousing: after the inspection is finished, the double-layer low-density polyethylene bag and the paper tube are adopted to carry out inner package and outer package in sequence, and finally, the materials are stored in a storage area.
2. The method for preparing the soft capsule film coating premix according to claim 1, wherein the color monitoring of the dispersed material in the dispersing step is performed by a colorimeter method.
3. The method of claim 1, wherein the dispersion step is performed by setting the mixing granulator to a rotation speed of 300 rpm.
4. The application of the soft capsule film coating premix is characterized by comprising the following steps:
a. dosage of the film coating premix: the actual weight gain is determined by the result of the disintegration time limit detection of the coated pill core in the coating process;
b. calculating the dosage of the film coating premix; the mass ratio of the film coating premix to the coating liquid is solid content, the mass of the pill core to be coated is determined, theoretical weight gain is set, and the dosage of the solvent and the film coating premix is calculated;
c. preparing a coating solution:
the size of the dosing tank is as follows: the height-diameter ratio of the mixing tank is 1.0-2.0, the volume of the container is 1.5-2.0 times of the coating liquid amount, and the diameter of the stirring paddle is about 1/3 of the mixing tank;
pouring the prepared solvent into a mixing tank with stirring, and starting stirring;
thirdly, slowly adding the weighed film coating premix to the vortex of the stirred solvent in a flowing manner, and finishing the adding within 3-5 minutes;
d. basic parameters of the film coating machine:
e. adjusting the spray gun:
the spray guns are vertical to the pill bed and are 20-30 cm apart, the sector of the coating liquid sprayed out of the spray nozzles is arranged in the upper middle part of the pill bed, two adjusting bolts are arranged on the spray guns, the atomization adjustment can be adjusted until the atomization surfaces of the three spray guns are not overlapped, the spray amount adjustment can be adjusted according to the actual situation in the coating process, so that the spray amount reaches the maximum under certain rotating speed, air inlet and outlet amount and pill core temperature, namely, the hand feeling feels that the surface of the pill core which is just sprayed with the coating liquid has a damp feeling but does not generate a pill sticking phenomenon;
f. controlling various parameters in the coating process:
after the preparation work is done, opening homogenate and guniting to start coating:
rotation speed:
setting a medium rotating speed of 2-3 rpm for avoiding the adhesion of the pill cores when coating is started, and after the coating is carried out for 20-30 minutes, increasing the rotating speed by protecting a coating layer, wherein the final coating stage can reach 6-10 rpm;
② temperature of the pill core:
controlling the temperature of the pellet core at 35-40 ℃ in the coating process;
regulating atomization:
in the early coating process, the atomization is adjusted to be maximum, and in the later period, the atomization is adjusted to be small for increasing the brightness of the color;
controlling the spraying amount:
in the whole coating process, the spraying amount is the maximum amount under the set parameters, namely under the condition that the rotating speed and the temperature of the pill cores are determined, the pill cores which are just sprayed with the coating liquid are felt to be moist by hands but not to be sticky, and the pill cores at the bottommost part of the tablet bed are basically dry;
g. cleaning the coating machine:
after coating, washing with ethanol, sodium carbonate or sodium hydroxide alkaline solution.
5. The use of the soft capsule film coating premix according to claim 4, wherein the coating solution is prepared in step c by stirring for at least 45 minutes to dissolve and disperse the coating solution in the solvent.
6. The use of the soft capsule film coating premix according to claim 5, wherein the coating liquid with poor fluidity is applied in step f while the rotation speed of the coating machine is increased.
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| CN202110424712.6A CN113209038A (en) | 2021-04-20 | 2021-04-20 | Preparation method and application of soft capsule film coating premix |
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| CN202110424712.6A CN113209038A (en) | 2021-04-20 | 2021-04-20 | Preparation method and application of soft capsule film coating premix |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177304A (en) * | 2022-02-15 | 2022-03-15 | 天津嘉汇捷瑞医药科技有限公司 | Modified calcium carbonate film coating agent and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070272121A1 (en) * | 2004-02-28 | 2007-11-29 | Ideal Cures Pvt. Ltd. | Ready Mix Flavored Film Coating Systems |
| CN106727416A (en) * | 2016-12-29 | 2017-05-31 | 上海新菲尔生物科技有限公司 | A kind of film coating pre-mix dose and preparation method for soft capsule |
| CN110585162A (en) * | 2019-09-23 | 2019-12-20 | 天津嘉汇捷瑞医药科技有限公司 | Enteric film coating premix for soft capsules and preparation method thereof |
-
2021
- 2021-04-20 CN CN202110424712.6A patent/CN113209038A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070272121A1 (en) * | 2004-02-28 | 2007-11-29 | Ideal Cures Pvt. Ltd. | Ready Mix Flavored Film Coating Systems |
| CN106727416A (en) * | 2016-12-29 | 2017-05-31 | 上海新菲尔生物科技有限公司 | A kind of film coating pre-mix dose and preparation method for soft capsule |
| CN110585162A (en) * | 2019-09-23 | 2019-12-20 | 天津嘉汇捷瑞医药科技有限公司 | Enteric film coating premix for soft capsules and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 胡崇茂 编著: "《药用辅料 薄膜包衣预混剂生产和应用》", 31 May 2014, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177304A (en) * | 2022-02-15 | 2022-03-15 | 天津嘉汇捷瑞医药科技有限公司 | Modified calcium carbonate film coating agent and preparation method thereof |
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Application publication date: 20210806 |