CN113201015B - Preparation method of allyl organophosphorus compound - Google Patents
Preparation method of allyl organophosphorus compound Download PDFInfo
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- CN113201015B CN113201015B CN202110446955.XA CN202110446955A CN113201015B CN 113201015 B CN113201015 B CN 113201015B CN 202110446955 A CN202110446955 A CN 202110446955A CN 113201015 B CN113201015 B CN 113201015B
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- organophosphorus compound
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- -1 allyl organophosphorus compound Chemical class 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 238000006243 chemical reaction Methods 0.000 claims abstract description 46
- 150000001875 compounds Chemical class 0.000 claims abstract description 33
- 150000004808 allyl alcohols Chemical class 0.000 claims abstract description 21
- 150000003751 zinc Chemical class 0.000 claims abstract description 17
- 239000003054 catalyst Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000003960 organic solvent Substances 0.000 claims abstract description 7
- 239000011261 inert gas Substances 0.000 claims abstract description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 33
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 24
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 239000011592 zinc chloride Substances 0.000 claims description 12
- 235000005074 zinc chloride Nutrition 0.000 claims description 12
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 9
- 150000002367 halogens Chemical group 0.000 claims description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 5
- 239000004246 zinc acetate Substances 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 3
- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 claims description 3
- 125000004104 aryloxy group Chemical group 0.000 claims description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 3
- 230000035484 reaction time Effects 0.000 claims description 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 20
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- 238000004440 column chromatography Methods 0.000 description 8
- 239000003208 petroleum Substances 0.000 description 8
- 238000000926 separation method Methods 0.000 description 7
- YFPJFKYCVYXDJK-UHFFFAOYSA-N Diphenylphosphine oxide Chemical compound C=1C=CC=CC=1[P+](=O)C1=CC=CC=C1 YFPJFKYCVYXDJK-UHFFFAOYSA-N 0.000 description 5
- 125000001188 haloalkyl group Chemical group 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- OBAJXDYVZBHCGT-UHFFFAOYSA-N tris(pentafluorophenyl)borane Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1B(C=1C(=C(F)C(F)=C(F)C=1F)F)C1=C(F)C(F)=C(F)C(F)=C1F OBAJXDYVZBHCGT-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BWCBFYRNWOIXIB-UHFFFAOYSA-N 1-methyl-2-(2-methylphenyl)phosphonoylbenzene Chemical compound CC1=CC=CC=C1P(=O)C1=CC=CC=C1C BWCBFYRNWOIXIB-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- ZHIPXAFNKGZMSC-UHFFFAOYSA-N bis(4-methylphenyl)-oxophosphanium Chemical compound C1=CC(C)=CC=C1[P+](=O)C1=CC=C(C)C=C1 ZHIPXAFNKGZMSC-UHFFFAOYSA-N 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5333—Arylalkane phosphine oxides or thioxides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/138—Halogens; Compounds thereof with alkaline earth metals, magnesium, beryllium, zinc, cadmium or mercury
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/04—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing carboxylic acids or their salts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/584—Recycling of catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention provides a preparation method of an allyl organophosphorus compound, which is characterized in that allyl alcohol derivatives and a P-H compound are used as raw materials under the condition of inert gas, zinc salt is used as a catalyst, and the allyl organophosphorus compound is prepared by reaction in an organic solvent.
Description
Technical Field
The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of an important organic synthesis intermediate, and more particularly relates to a preparation method of an allyl organophosphorus compound.
Background
Allyl organophosphorus compounds are important organic synthesis intermediates, and are widely applied to the fields of total synthetic chemistry, biochemistry, ligand chemistry, medicinal chemistry, agricultural chemistry, material science and the like. It has been found through studies over the years that allyl organophosphorus compounds can also act as a directing group for activating C-H bonds. In recent years, it has been found that phosphorus-hydrogen bonds are relatively reactive and can undergo high atom economy reactions.
Due to the importance of allyl organophosphorus compounds, research on the synthesis method of allyl organophosphorus compounds is also a corresponding hotspot in organic synthesis chemistry research.
The synthesis methods related to the allyl organophosphorus compounds at present mainly comprise the following methods:
(1) the target product allyl organophosphorus compound is prepared by taking terminal alkynol and diphenyl phosphine oxide as raw materials and transition metals (such as ruthenium, cadmium, silver and the like) as catalysts, few byproducts are generated in the whole reaction process, mainly water, and the byproducts are green, environment-friendly, non-toxic and harmless, but heavy metals are used as the catalysts in the reaction, so that the reaction is expensive or has large pollution, and the substrate selectivity is poor, without universality and economic benefit.
(2) The method is simple, efficient and in accordance with atom economy, but the existence of Pd faces certain limitation to the application of the method in the fields of medicines and materials.
(3) MBH alcohol and a P-H compound are used as raw materials to carry out reaction, a catalyst is not used in the reaction, a solvent is not needed, the catalyst is not used, the reaction is directly heated to react, only an allyl organophosphorus compound and water are finally obtained in the reaction, and the method is green, environment-friendly and high in atom economy. However, the substrate of this reaction is only practical for MBH alcohols and is not applicable to other alcohols.
(4) The allyl organophosphorus compound is prepared by heating and reacting allyl alcohol and a P-H compound serving as raw materials and tris (pentafluorophenyl) borane serving as a catalyst, wherein a metal catalyst is not used in the reaction, and the reaction can be carried out with or without a solvent, but the tris (pentafluorophenyl) borane is expensive and can form a partial mixture with a product, so that the difficulty of post-treatment is increased.
Disclosure of Invention
The invention aims to overcome a series of defects existing in the preparation of allyl organophosphorus compounds in the prior art, and provides a preparation method of the allyl organophosphorus compound, which is characterized in that allyl alcohol derivatives and P-H compounds are used as raw materials, zinc salt is used as a catalyst, and the allyl organophosphorus compound is prepared in an organic solvent under the condition of inert gas.
According to the preparation method of the allyl organophosphorus compound, the structural formula of the allyl alcohol derivative is shown in the specification
According to the preparation method of the allyl organophosphorus compound, the structural formula of the P-H compound is shown in the specification
The preparation method of the allyl organophosphorus compound disclosed by the invention is used for preparing the allyl organophosphorusThe structural formula of the compound is
The preparation method of the allyl organophosphorus compound, provided by the invention, is characterized in that R1-R4 are hydrogen, substituted or unsubstituted alkyl or alkoxy, or substituted or unsubstituted aryl or aryloxy; the R5-R6 are substituted or unsubstituted alkyl or substituted or unsubstituted aryl.
According to the preparation method of the allyl organophosphorus compound, preferably, R1-R4 are alkyl or alkoxy with 1-6 carbon atoms which are optionally substituted or unsubstituted; further preferably, the substituent is halogen.
According to the preparation method of the allyl organophosphorus compound, preferably, R1-R4 are optionally substituted or unsubstituted phenyl or phenoxy; more preferably, the substituent is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, a halogen, a nitro group, a hydroxyl group or a cyano group.
The process for preparing an allylorganophosphorus compound according to the present invention, wherein R5 to R6 are each an optionally substituted alkyl group having 1 to 6 carbon atoms; further preferably, the substituent is halogen.
According to the preparation method of the allyl organophosphorus compound, preferably, R5-R6 are optionally substituted or unsubstituted phenyl; more preferably, the substituent is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, a halogen, a nitro group, a hydroxyl group or a cyano group. .
According to the preparation method of the allyl organophosphorus compound, the organic solvent is selected from one or more of acetonitrile, DMF, tetrahydrofuran, benzene, chloroform, toluene or dioxane.
The preparation method of the allyl organophosphorus compound is characterized in that the reaction is carried out at the temperature of 20-100 ℃.
The preparation method of the allyl organophosphorus compound is characterized in that the reaction is preferably carried out at the temperature of 50-100 ℃.
According to the preparation method of the allyl organophosphorus compound, the reaction time is 1-10 h.
The process for producing an allylorganophosphorus compound according to the present invention is characterized in that: the molar ratio of the allyl alcohol derivative to the P-H compound to the zinc salt is 1: 1-2: 0.01-0.1.
The process for producing an allylorganophosphorus compound according to the present invention is characterized in that: the mol ratio of the allyl alcohol derivative, the P-H compound and the zinc salt is preferably 1: 1-2: 0.01-0.05.
The preparation method of the allyl organophosphorus compound is characterized by comprising the following steps: the zinc salt is zinc chloride or zinc acetate.
The preparation method of the allyl organophosphorus compound is characterized by comprising the following steps: the zinc salt is preferably zinc chloride.
The preparation method of the allyl organophosphorus compound is characterized by comprising the following steps: the inert gas is selected from nitrogen or helium.
The main contributions of the present invention with respect to the prior art are the following:
(1) compared with the prior art, the allyl organophosphorus compound is prepared by taking the allyl alcohol derivative and the P-H compound as raw materials and taking the zinc salt as the catalyst, and the catalyst is simple and easy to obtain, has low price, is more economic and environment-friendly and is suitable for large-scale production.
(2) The zinc salt is used as the catalyst, particularly zinc chloride, has high reaction activity and mild reaction, has the yield which is equivalent to or even higher than that of part of the prior art in terms of yield, and has simpler post-treatment, less impurities and high purity because of incompatibility with a system by using the zinc salt as the catalyst.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present disclosure more apparent, the technical solutions of the embodiments of the present disclosure are clearly and completely described. It is to be understood that the described embodiments are only a few embodiments of the present disclosure, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the disclosure without any inventive step, are within the scope of protection of the disclosure.
The preparation method of the allyl organophosphorus compound is characterized in that under the inert gas condition, allyl alcohol derivatives and P-H compounds are used as raw materials, zinc salt is used as a catalyst, and the allyl organophosphorus compound is prepared by reaction in an organic solvent.
According to the preparation method of the allyl organophosphorus compound, the structural formula of the allyl alcohol derivative is shown in the specification
According to the preparation method of the allyl organophosphorus compound, the structural formula of the P-H compound is shown in the specification
According to the preparation method of the allyl organophosphorus compound, the structural formula of the allyl organophosphorus compound is shown in the specification
The preparation method of the allyl organophosphorus compound, provided by the invention, is characterized in that R1-R4 are hydrogen, substituted or unsubstituted alkyl or alkoxy, or substituted or unsubstituted aryl or aryloxy; the R5-R6 are substituted or unsubstituted alkyl or substituted or unsubstituted aryl.
According to the preparation method of the allyl organophosphorus compound, preferably, R1-R4 are alkyl or alkoxy with 1-6 carbon atoms which are optionally substituted or unsubstituted; further preferably, the substituent is halogen.
According to the preparation method of the allyl organophosphorus compound, preferably, R1-R4 are optionally substituted or unsubstituted phenyl or phenoxy; more preferably, the substituent is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, a halogen, a nitro group, a hydroxyl group or a cyano group.
The process for preparing an allylorganophosphorus compound according to the present invention, wherein R5 to R6 are each an optionally substituted alkyl group having 1 to 6 carbon atoms; further preferably, the substituent is halogen.
According to the preparation method of the allyl organophosphorus compound, preferably, R5-R6 are optionally substituted or unsubstituted phenyl; more preferably, the substituent is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, a halogen, a nitro group, a hydroxyl group or a cyano group. .
According to the preparation method of the allyl organophosphorus compound, the organic solvent is selected from one or more of acetonitrile, DMF, tetrahydrofuran, benzene, chloroform, toluene or dioxane.
The preparation method of the allyl organophosphorus compound is characterized in that the reaction is carried out at the temperature of 20-100 ℃.
The preparation method of the allyl organophosphorus compound is characterized in that the reaction is preferably carried out at the temperature of 50-100 ℃.
According to the preparation method of the allyl organophosphorus compound, the reaction time is 1-10 h.
The process for producing an allylorganophosphorus compound according to the present invention is characterized in that: the molar ratio of the allyl alcohol derivative to the P-H compound to the zinc salt is 1: 1-2: 0.01-0.1.
The process for producing an allylorganophosphorus compound according to the present invention is characterized in that: the mol ratio of the allyl alcohol derivative, the P-H compound and the zinc salt is preferably 1: 1-2: 0.01-0.05.
The preparation method of the allyl organophosphorus compound is characterized by comprising the following steps: the zinc salt is zinc chloride or zinc acetate.
The preparation method of the allyl organophosphorus compound is characterized by comprising the following steps: the zinc salt is preferably zinc chloride.
The preparation method of the allyl organophosphorus compound is characterized by comprising the following steps: the inert gas is selected from nitrogen or helium.
Example 1
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 (ii) phenyl, R 3 ＝H、R 4 Phenyl group), 0.2mol diphenyl phosphine oxide (R) 5 、R 6 Phenyl) and 1mmol of zinc chloride are placed in a reaction vessel, 50mL of acetonitrile is added, the system is stirred to be uniform, then the temperature is slowly heated to 80 ℃, the temperature is kept for reaction for 5 hours, after the reaction is finished, the system is naturally cooled to the room temperature, the reduced pressure concentration is carried out, and the system is subjected to column chromatography separation (V) Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylorganophosphorus compound in 93.7% yield.
Example 2
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.15mol diphenyl phosphine oxide (R) 5 、R 6 Phenyl) and 1mmol of zinc chloride are placed in a reaction vessel, 50mL of acetonitrile is added, the system is stirred to be uniform, then the temperature is slowly heated to 80 ℃, the temperature is kept for reaction for 5 hours, after the reaction is finished, the system is naturally cooled to the room temperature, the reduced pressure concentration is carried out, and the system is subjected to column chromatography separation (V) Petroleum ether :V Acetic acid ethyl ester 1:1) to yield the corresponding allylorganophosphorus compound in 92.2% yield.
Example 3
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.11mol diphenyl phosphine oxide (R) 5 、R 6 Phenyl) and 5mmol of zinc chloride are placed in a reaction vessel, 50mL of acetonitrile is added, the system is stirred to be uniform, then the temperature is slowly heated to 80 ℃, the temperature is kept for reaction for 10 hours, after the reaction is finished, the system is naturally cooled to the room temperature, the reduced pressure concentration is carried out, and the system is subjected to column chromatography separation (V) Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylorganophosphorus compound in 97.1% yield.
Example 4
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.15mol of di-p-tolylphosphine oxide (R) 5 、R 6 Placing p-tolyl) and 5mmol zinc chloride in a reaction vessel, adding 50mL acetonitrile, stirring the system to be uniform, slowly heating to 80 deg.C, maintaining the temperature for reaction for 10h, naturally cooling the system to room temperature after the reaction is finished, concentrating under reduced pressure, and performing column chromatography (V) Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylorganophosphorus compound in 93.5% yield.
Example 5
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.2mol of di-p-fluorophenyl phosphine oxide (R) 5 、R 6 Putting p-fluorophenyl) and 1mmol of zinc chloride into a reaction vessel, adding 50mL of acetonitrile, stirring the system to be uniform, slowly heating to 80 ℃, keeping the temperature for reaction for 10 hours, naturally cooling the system to room temperature after the reaction is finished, concentrating under reduced pressure, and performing column chromatography separation (V) on the system Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylic organophosphorus compound in 95% yield.
Example 6
In the presence of nitrogen gasUnder protection, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.2mol of di-p-methoxyphenylphosphine oxide (R) 5 、R 6 Putting p-methoxyphenyl) and 1mmol zinc chloride into a reaction vessel, adding 50mL acetonitrile, stirring the system to be uniform, then slowly heating to 80 ℃, keeping the temperature for reaction for 10h, after the reaction is finished, naturally cooling the system to room temperature, concentrating under reduced pressure, and carrying out column chromatography separation (V) on the system Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylorganophosphorus compound in 90.7% yield.
Example 7
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.11mol diphenyl phosphine oxide (R) 5 、R 6 Phenyl) and 5mmol of zinc acetate are placed in a reaction vessel, 50mL of acetonitrile is added, the system is stirred to be uniform, then the temperature is slowly heated to 80 ℃, the temperature is kept for reaction for 10 hours, after the reaction is finished, the system is naturally cooled to the room temperature, the pressure is reduced and the concentration is carried out, and the system is subjected to column chromatography separation (V) Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylorganophosphorus compound in 91.5% yield.
Example 8
Under the protection of nitrogen, 0.1mol of allyl alcohol derivative (R) 1 ＝H、R 2 Arthrophenyl, R 3 ＝H、R 4 Phenyl group), 0.2mol of di-o-tolylphosphine oxide (R) 5 、R 6 All the components are o-tolyl) and 10mmol of zinc acetate are placed in a reaction vessel, 50mL of acetonitrile is added, the system is stirred to be uniform, then the temperature is slowly heated to 80 ℃, the temperature is kept for reaction for 10 hours, after the reaction is finished, the system is naturally cooled to the room temperature, the reduced pressure concentration is carried out, and the system is subjected to column chromatography separation (V) Petroleum ether :V Ethyl acetate 1:1) to yield the corresponding allylorganophosphorus compound in 90.5% yield.
Finally, it should be noted that: it should be understood that the above examples are only for clearly illustrating the present invention and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. This need not be, nor should it be exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the scope of the invention.
Claims (10)
1. A preparation method of allyl organophosphorus compound is characterized in that allyl alcohol derivatives and P-H compounds are used as raw materials, zinc salt is used as catalyst, and allyl organophosphorus compound is prepared by reaction in organic solvent under inert gas condition; the structural formula of the allyl alcohol derivative is shown in the specification
The structural formula of the P-H compound is shown as
The structural formula of the allyl organophosphorus compound is
Wherein, R is 1 -R 4 Is hydrogen, substituted or unsubstituted alkyl or alkoxy, the substituent is halogen, or substituted or unsubstituted aryl or aryloxy, the substituent is alkyl with the carbon number of 1-6, alkoxy with the carbon number of 1-6, halogenated alkyl with the carbon number of 1-6, halogen, nitro, hydroxyl or cyano; the R is 5 -R 6 Is substituted or unsubstituted alkyl, the substituent is halogen or substituted or unsubstituted aryl, and the substituent is alkyl with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, halogenated alkyl with 1-6 carbon atoms, halogen, nitro, hydroxyl or cyano.
2. The process for producing an allylorganophosphorus compound according to claim 1, wherein R is 1 -R 4 Is optionally substituted or notSubstituted alkyl or alkoxy having 1 to 6 carbon atoms.
3. The process for producing an allylorganophosphorus compound according to claim 1, wherein R is 1 -R 4 Is an optionally substituted or unsubstituted phenyl or phenoxy group.
4. The process for producing an allylorganophosphorus compound according to claim 1, wherein R is 5 -R 6 Is an optionally substituted alkyl group having 1 to 6 carbon atoms.
5. The method for preparing an allylorganophosphorus compound according to claim 1, wherein R is 5 -R 6 Is optionally substituted or unsubstituted phenyl.
6. The method for preparing an allylic organophosphorus compound according to claim 1, wherein the organic solvent is one or more selected from acetonitrile, DMF, tetrahydrofuran, benzene, chloroform, toluene, and dioxane.
7. The method according to claim 1, wherein the reaction is carried out at a temperature of 20 to 100 ℃; the reaction time is 1-10 h.
8. The method according to claim 1, wherein the reaction is carried out at a temperature of 50 to 100 ℃.
9. The process according to claim 1, wherein: the molar ratio of the allyl alcohol derivative to the P-H compound to the zinc salt is 1: 1-2: 0.01-0.1.
10. The process according to claim 1, wherein: the zinc salt is zinc chloride or zinc acetate.
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| CN105694842A (en) * | 2016-03-16 | 2016-06-22 | 中国科学技术大学 | Electrochromic material, preparation method thereof, black electrochromic material and preparation method thereof |
| CN108774263A (en) * | 2018-06-26 | 2018-11-09 | 广东工业大学 | A kind of synthetic method of allyl oxidation phosphine compound |
| CN111943980A (en) * | 2020-09-15 | 2020-11-17 | 南京工业大学 | Allyl phosphorus compound and preparation method thereof |
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| CN108774263A (en) * | 2018-06-26 | 2018-11-09 | 广东工业大学 | A kind of synthetic method of allyl oxidation phosphine compound |
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