CN113200489A - Reaction tube compresses tightly upper cover system - Google Patents
Reaction tube compresses tightly upper cover system Download PDFInfo
- Publication number
- CN113200489A CN113200489A CN202110506906.0A CN202110506906A CN113200489A CN 113200489 A CN113200489 A CN 113200489A CN 202110506906 A CN202110506906 A CN 202110506906A CN 113200489 A CN113200489 A CN 113200489A
- Authority
- CN
- China
- Prior art keywords
- upper cover
- side plate
- support arm
- reaction tube
- pressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B3/00—Closing bottles, jars or similar containers by applying caps
- B67B3/02—Closing bottles, jars or similar containers by applying caps by applying flanged caps, e.g. crown caps, and securing by deformation of flanges
- B67B3/10—Capping heads for securing caps
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention provides a reaction tube upper cover pressing system which comprises a fixing support, a first side plate and a second side plate, wherein the first side plate and the second side plate are arranged oppositely and are connected with the fixing support, a first support arm is connected to the first side plate in a sliding mode, a second support arm is connected to the second side plate in a sliding mode, an upper cover assembly is connected between the first support arm and the second support arm, and the reaction tube upper cover pressing system further comprises a driving device, and the driving device can drive the first support arm, the second support arm and the upper cover assembly to move linearly in the height direction together so that the upper cover assembly can apply force to a top cover of a reaction tube. The driving device can drive the first support arm and the second support arm to drive the upper cover assembly to generate linear motion in the height direction, and when the upper cover assembly is driven to move downwards, the automatic compression between the reaction tube and the tube seat below the upper cover assembly is realized, so that the automatic control of the compression between the reaction tube and the tube seat in the prior art can be realized, and the structure is simple, compact and small.
Description
Technical Field
The invention belongs to the technical field of in-vitro diagnosis instrument design, and particularly relates to a reaction tube pressing upper cover system.
Background
In the real-time fluorescent quantitative polymerase chain reaction (RT-PCR) process, a reaction tube (such as a common reaction tube) needs to be tightly pressed against a base to ensure good heat transfer, which is the basis for successful experiment. Furthermore, the fluorescent light emitted by the fluorescent dye in the reaction tube needs to be detected while the reaction tube and the tube seat are pressed tightly. At present, the common electric heating upper cover in the field is opened and closed manually and pressed down, is large in size, has certain requirements on placing of a single reaction tube, needs to be placed symmetrically, prevents bad contact caused by inclination of the heat cover, and is difficult to integrate into various liquid treatment workstations or miniaturized and portable in-vitro diagnosis equipment.
In recent years, with the development of science and technology, the weight and size of instruments and equipment have special requirements in the fields of medical instruments and the like, and therefore, the development of in-vitro diagnostic equipment towards miniaturization and automation is promoted. In the field of molecular diagnosis, in order to reduce the size of the RT-PCR module and integrate the RT-PCR module into a miniaturized and automated fully automated molecular diagnostic apparatus, it is first necessary to develop a small-sized, automatically openable and closable cover.
Disclosure of Invention
Therefore, the technical problem to be solved by the present invention is to provide a reaction tube pressing and capping system, which is compact and small, and can be controllably pressed down to realize automatic pressing between the reaction tube and the tube seat.
In order to solve the above problems, the present invention provides a reaction tube upper cover pressing system, which includes a fixing support, a first side plate, a second side plate, wherein the first side plate and the second side plate are disposed opposite to each other and are both connected to the fixing support, a first support arm is slidably connected to the first side plate, a second support arm is slidably connected to the second side plate, and an upper cover assembly is connected between the first support arm and the second support arm.
Preferably, the driving device includes a screw motor, a connecting rod is connected to a screw rod of the screw motor, the connecting rod can reciprocate along an axial direction of the screw motor under the action of the screw rod, two ends of the connecting rod are respectively rotatably connected with a first pressure lever and a second pressure lever, the first pressure lever is further rotatably connected with the first support arm, and the second pressure lever is further rotatably connected with the second support arm.
Preferably, two ends of the connecting rod are respectively connected with the first side plate and the second side plate in a sliding manner.
Preferably, the first side plate and the second side plate are respectively connected with the fixed bracket in a sliding manner, and two ends of the connecting rod are respectively connected with the first side plate and the second side plate through elastic pieces.
Preferably, the fixing support is correspondingly provided with a limiting column on the sliding path corresponding to the first side plate and/or the second side plate.
Preferably, the upper cover assembly comprises an upper cover body, at least one through hole is formed in the upper cover body, and a focusing lens is embedded in the through hole.
Preferably, the upper cover assembly further includes a heating member.
Preferably, the heating means comprises an electrically heated film.
Preferably, the upper cover assembly further comprises at least two heat insulation pieces, and the two heat insulation pieces are respectively arranged between the upper cover body and the first support arm and between the upper cover body and the second support arm; and/or the electric heating film is adhered to one side of the upper cover body through heat-conducting double-sided adhesive.
Preferably, the heat insulation piece is made of one of polytetrafluoroethylene, polyformaldehyde and polystyrene.
According to the reaction tube pressing upper cover system provided by the invention, the driving device can drive the first support arm and the second support arm to drive the upper cover component to generate linear motion in the height direction, and when the upper cover component is driven to move downwards, the automatic pressing between the reaction tube and the tube seat below the upper cover component is realized, so that the automatic control of the pressing between the reaction tube and the tube seat in the prior art can be realized, and the reaction tube pressing upper cover system is simple, compact and small in structure.
Drawings
FIG. 1 is a schematic perspective view of a reactor tube pressing and capping system according to an embodiment of the present invention, illustrating a state in which no force is applied to the reactor tube by the reactor tube pressing and capping system;
FIG. 2 is a schematic perspective view of a reactor tube pressing and capping system according to an embodiment of the present invention, illustrating a state in which the reactor tube pressing and capping system applies force to a reactor tube;
FIG. 3 is a partial schematic view of the force application transmission-related components of the reactor tube pressing and capping system according to the embodiment of the present invention, in which horizontal arrows and vertical arrows show the directions of the paths of the horizontal linear reciprocating motion and the vertical linear reciprocating motion;
FIG. 4 is an assembled view of the cover assembly of FIG. 1 with the first arm and the second arm disassembled.
The reference numerals are represented as:
11. a first side plate; 12. a second side plate; 21. a first support arm; 22. a second support arm; 3. an upper cover assembly; 31. an upper cover body; 311. a through hole; 32. a focusing lens; 33. electrically heating the film; 34. a thermal insulation member; 41. a screw motor; 42. a screw rod; 43. a connecting rod; 431. an elastic member; 51. a first pressure lever; 52. a second compression bar; 6. a limiting column; 61. a first linear guide rail assembly; 62. a third linear guide assembly; 63. a second linear guide assembly; 100. a reaction tube; 200. a socket.
Detailed Description
Referring to fig. 1 to 4 in combination, according to an embodiment of the present invention, there is provided a reaction tube pressing upper cover system, including a first side plate 11, a second side plate 12, the first side plate 11 and the second side plate 12 are disposed opposite to each other and are connected to the fixing bracket (not shown), a first support arm 21 is connected on the first side plate 11 in a sliding way, a second support arm 22 is connected on the second side plate 12 in a sliding way, the upper cover component 3 is connected between the first support arm 21 and the second support arm 22, and the upper cover component also comprises a driving device, the driving device can drive the first support arm 21, the second support arm 22 and the upper cover component 3 to move linearly together along the height direction, so that the upper cover assembly 3 can apply force on the top cover of the reaction tube 100, and the reaction tube 100 is placed on the tube seat 200, thereby realizing the compression between the reaction tube 100 and the tube seat 200. In the technical scheme, the driving device can drive the first support arm 21 and the second support arm 22 to drive the upper cover assembly 3 to generate linear motion in the height direction, and when the upper cover assembly 3 is driven to move downwards, the automatic compression between the reaction tube 100 and the tube seat 200 below the upper cover assembly is realized, so that the automatic control of the compression between the reaction tube and the tube seat in the prior art can be realized, and the structure is simple, compact and small. The first arm 21 and the second arm 22 are slidably connected to the first side plate 11 and the second side plate 12 through a first linear guide assembly 61, for example, the first linear guide assembly 61 is specifically composed of a sliding block and a guide rail matched with the sliding block, for example, as known in the art, and the description of the present invention is omitted. The reaction tube may be, for example, a commercially available EP tube, different volumes of which, for example, 100 microliters, 200 microliters, 1 milliliter and 5 milliliters, can be compatible with the cover.
In some embodiments, the driving device includes a lead screw motor 41 having a lead screw 42 with a connecting rod 43 connected thereto, the connecting rod 43 can reciprocate along an axial direction of the lead screw motor 41 under the action of the lead screw 42, a first pressing rod 51 and a second pressing rod 52 are respectively rotatably connected to two ends of the connecting rod 43, the first pressing rod 51 is further rotatably connected (specifically, for example, hinged) to the first arm 21, and the second pressing rod 52 is further rotatably connected (specifically, for example, hinged) to the second arm 22. In this technical solution, for example, the rotatable swing arm structure between the connecting rod 43 and the first pressing rod 51 or the second pressing rod 52 converts the horizontal axial displacement of the lead screw 42 into the vertical height displacement of the first support arm 21 and the second support arm 22, thereby further making the upper cover structure of the present invention more compact and smaller. Further, the two ends of the connecting rod 43 are respectively connected with the first side plate 11 and the second side plate 12 in a sliding manner, specifically, for example, the sliding connection between the first side plate and the second side plate is respectively realized through the second linear guide assembly 63, so that the structure of the upper cover becomes an organic whole, which is beneficial to improving the stability of the overall structure of the upper cover and can ensure smooth linear motion. It should be noted that the linear displacement of the lead screw 42 determines the change of the vertical height of the first arm 21 and the second arm 22, so as to control the magnitude of the applied force.
In some embodiments, the first side plate 11 and the second side plate 12 are slidably connected to the fixing bracket, for example, the slidable connection is achieved through a third linear guide assembly 62, two ends of the connecting rod 43 are connected to the first side plate 11 and the second side plate 12 through elastic members 431, so that when the connecting rod 43 is driven by the lead screw 42 to move toward one side of the reaction tube 100, the first side plate 11 and the second side plate 12 can be driven by the elastic members 431 to approach the reaction tube 100, so that when the upper cover is not pressed, the upper cover assembly 3 can not be blocked in the area above the position of the reaction tube 100, and the placing process of the reaction tube 100 can be facilitated. The elastic member 431 may be, for example, a spring, and it is understood that the spring should match (without being limited) the friction force of the first side plate 11 or the second side plate 12 during the sliding process in terms of stiffness selection, and specifically, when moving towards the reaction tube 100, it can sufficiently drive the first side plate 11 and the second side plate 12 to move together along with the connecting rod 43.
In some embodiments, the fixing bracket is further provided with a limiting column 6 corresponding to the sliding path of the first side plate 11 and/or the second side plate 12, respectively, for limiting the horizontal linear displacement of the first side plate 11 and the second side plate 12, that is, when the front ends of the first side plate 11 and the second side plate 12 contact with the limiting column 6, the first side plate 11 and the second side plate 12 will not follow the connecting rod 43 to move towards the reaction tube 100 any more, but instead the first pressing rod 51 and the second pressing rod 52 will rotate around their respective rotational connection points with the connecting rod 43, and since the other ends of the first pressing rod 51 and the second pressing rod 52 (for example, the lower ends of the first pressing rod 51 and the second pressing rod 52 in fig. 1) pass through the corresponding first support arm 21 and the second support arm 22 and are limited by the first linear guide assembly 61 to reciprocate in the vertical direction, thereby, the horizontal movement of the link 43 is converted into the vertical movement of the first arm 21 and the second arm 22. It should be noted that, in the present invention, the first linear guide assembly 61, the second linear guide assembly 63, and the third linear guide assembly 62 are arranged to make the upper cover have a relatively strong rigidity, so that the upper cover can be kept stable under the condition of unbalanced load, no inclination is generated, and one or more reaction tubes can be compressed in practical application.
In some embodiments, the upper cover assembly 3 includes an upper cover body 31, and at least one through hole 311 is configured on the upper cover body 31, and the focusing lens 32 is embedded in the through hole 311, for example, eight through holes 311 are provided in one embodiment of the present invention, and there are eight focusing lenses 32 correspondingly. In this technical solution, it can be understood that the specific number of the through holes 311 is adapted to the specific number of the reaction tubes 100 below, and the through holes correspond to the positions of the tube openings of the reaction tubes 100, so that the upper cover has the function of focusing fluorescence emitted by the target analyte in the sample in each reaction tube 100 through the focusing lens 32 while the reaction tubes 100 and the tube seat 200 are pressed. The focusing lens 32 may be of different shapes, such as spherical, semi-spherical, cylindrical.
In some embodiments, the upper cover assembly 3 further comprises a heating component, in particular, an electric heating film 33, wherein the electric heating film 33 is adhered to one side of the upper cover body 31 by a heat-conducting double-sided adhesive, and is used for keeping the temperature of the upper cover constant, generally, the temperature can be set between 40 ℃ and 120 ℃, and it can be understood that, in order to ensure the control of the temperature, a corresponding temperature sensor is correspondingly arranged on the upper cover body 31.
In some embodiments, the upper cover assembly 3 further includes at least two heat insulation members 34, and the two heat insulation members 34 are respectively located between the upper cover body 31 and the first arm 21 and between the upper cover body 31 and the second arm 22, so as to prevent heat from being transferred toward the first arm 21 and the second arm 22, and ensure effective utilization of heat. The heat insulation member 34 may be made of one of teflon, polyoxymethylene, and polystyrene.
The socket 200 may use a heating base with a constant temperature function, and may also use a thermal cycling module for PCR.
It is readily understood by a person skilled in the art that the advantageous ways described above can be freely combined, superimposed without conflict.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.
Claims (10)
1. The utility model provides a reaction tube compresses tightly upper cover system, its characterized in that, includes first curb plate (11), second curb plate (12), first curb plate (11), second curb plate (12) set up relatively and all are connected with fixed bolster, sliding connection has first support arm (21) on first curb plate (11), sliding connection has second support arm (22) on second curb plate (12), first support arm (21) with be connected with upper cover subassembly (3) between second support arm (22), still include drive arrangement, drive arrangement can drive first support arm (21), second support arm (22), upper cover subassembly (3) are along direction of height linear motion together, so that upper cover subassembly (3) can the application of force on the top cap of reaction tube (100).
2. The reaction tube pressing and capping system according to claim 1, wherein the driving device comprises a screw motor (41) having a screw (42) with a connecting rod (43) connected thereto, the connecting rod (43) can reciprocate along an axial direction of the screw motor (41) under the action of the screw (42), a first pressing rod (51) and a second pressing rod (52) are respectively rotatably connected to two ends of the connecting rod (43), the first pressing rod (51) is further rotatably connected to the first support arm (21), and the second pressing rod (52) is further rotatably connected to the second support arm (22).
3. The reactor tube pressing upper cover system according to claim 2, wherein two ends of the connecting rod (43) are respectively connected with the first side plate (11) and the second side plate (12) in a sliding manner.
4. The reaction tube pressing upper cover system according to claim 3, wherein the first side plate (11) and the second side plate (12) are slidably connected with the fixing bracket respectively, and two ends of the connecting rod (43) are connected with the first side plate (11) and the second side plate (12) respectively through an elastic piece (431).
5. The reaction tube pressing upper cover system according to claim 4, wherein a limiting column (6) is correspondingly arranged on the fixed bracket on the sliding path corresponding to the first side plate (11) and/or the second side plate (12).
6. The reactor tube pressing upper cover system according to claim 1, wherein the upper cover assembly (3) comprises an upper cover body (31), at least one through hole (311) is formed on the upper cover body (31), and a focusing lens (32) is embedded in the through hole (311).
7. The reactor tube pressing and capping system as claimed in claim 6, wherein the capping assembly (3) further comprises a heating means.
8. The reactor tube pressing lid system according to claim 7, wherein the heating means comprises an electrically heated film (33).
9. The reactor tube pressing cover system according to claim 7, wherein the cover assembly (3) further comprises at least two heat insulators (34), the two heat insulators (34) are respectively located between the cover body (31) and the first arm (21) and between the cover body (31) and the second arm (22); and/or the electric heating film (33) is adhered to one side of the upper cover body (31) through heat conduction double-sided adhesive.
10. The reactor tube pressing and capping system as claimed in claim 9, wherein the heat insulator (34) is made of one of teflon, polyoxymethylene, and polystyrene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110506906.0A CN113200489B (en) | 2021-05-10 | 2021-05-10 | Reaction tube compresses tightly upper cover system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110506906.0A CN113200489B (en) | 2021-05-10 | 2021-05-10 | Reaction tube compresses tightly upper cover system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113200489A true CN113200489A (en) | 2021-08-03 |
| CN113200489B CN113200489B (en) | 2022-10-14 |
Family
ID=77030642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110506906.0A Active CN113200489B (en) | 2021-05-10 | 2021-05-10 | Reaction tube compresses tightly upper cover system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113200489B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105668474A (en) * | 2016-02-25 | 2016-06-15 | 东莞市第三人民医院 | Novel vacuum blood collection tube cover opening and closing all-in-one machine |
| JP3206657U (en) * | 2016-07-15 | 2016-09-29 | 株式会社 バイオ・リジェネレーションズ | Multiple PCR tube cap remover |
| CN209143641U (en) * | 2018-10-19 | 2019-07-23 | 北京镁伽机器人科技有限公司 | Switch cover external member and with switch lid function robot |
| CN111349543A (en) * | 2020-03-11 | 2020-06-30 | 杭州博日科技有限公司 | PCR hot cover subassembly and PCR appearance |
| CN213097176U (en) * | 2020-05-12 | 2021-05-04 | 扬州工业职业技术学院 | Horizontal adjustable cradle |
| CN215574580U (en) * | 2021-05-10 | 2022-01-18 | 新羿制造科技（北京）有限公司 | Pressing upper cover equipment for multiple reaction tubes |
-
2021
- 2021-05-10 CN CN202110506906.0A patent/CN113200489B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105668474A (en) * | 2016-02-25 | 2016-06-15 | 东莞市第三人民医院 | Novel vacuum blood collection tube cover opening and closing all-in-one machine |
| JP3206657U (en) * | 2016-07-15 | 2016-09-29 | 株式会社 バイオ・リジェネレーションズ | Multiple PCR tube cap remover |
| CN209143641U (en) * | 2018-10-19 | 2019-07-23 | 北京镁伽机器人科技有限公司 | Switch cover external member and with switch lid function robot |
| CN111349543A (en) * | 2020-03-11 | 2020-06-30 | 杭州博日科技有限公司 | PCR hot cover subassembly and PCR appearance |
| CN213097176U (en) * | 2020-05-12 | 2021-05-04 | 扬州工业职业技术学院 | Horizontal adjustable cradle |
| CN215574580U (en) * | 2021-05-10 | 2022-01-18 | 新羿制造科技（北京）有限公司 | Pressing upper cover equipment for multiple reaction tubes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113200489B (en) | 2022-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN215574580U (en) | Pressing upper cover equipment for multiple reaction tubes | |
| CN101952412A (en) | Thermal cycler with self-adjusting lid | |
| CN113200489B (en) | Reaction tube compresses tightly upper cover system | |
| CN111674908A (en) | Test tube is clamping device in batches | |
| Richter | Hydrogels for actuators | |
| CN100489525C (en) | Cell organism microsystem for detecting cell surface marker and detection method thereof | |
| CN112779157A (en) | PCR reaction device with sample preparation function | |
| CN102755761A (en) | Biomolecule extraction device | |
| CN215429150U (en) | Blood sample storage rack for clinical laboratory of hospital | |
| CN214019255U (en) | Condensing device for rotary evaporator | |
| CN211586661U (en) | Motion mechanism and detection device | |
| WO2009121363A1 (en) | Adjustable chip holder | |
| CN208717346U (en) | Sample processing system | |
| CN215843133U (en) | Multi-purpose test tube placing rack for clinical laboratory | |
| CN212975180U (en) | Chemistry experiment heating frame | |
| CN215940041U (en) | Adjustable bacterial culture test tube support inclines | |
| CN216726945U (en) | Oscillation device for clinical medical examination | |
| CN216864170U (en) | Micro-droplet detection biological analysis system | |
| CN217542821U (en) | Stepping type transmission mechanism for urine analyzer | |
| CN219631161U (en) | Ultrasonic jacking linkage structure of real-time fluorescence detection analyzer | |
| CN216550436U (en) | Double-light-path micro-droplet chip analyzer | |
| CN214735785U (en) | Liquid drop pushing device | |
| CN212855819U (en) | Three-degree-of-freedom liquid transfer device based on delta robot and closed clamping box | |
| CN213000113U (en) | Clinical laboratory's test-tube rack in adjustable aperture of carousel formula | |
| CN214650556U (en) | Medicine insulation box with warm area rapidly entering cold area |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |