CN113194906A - Kit for skin care - Google Patents

Abstract

The present invention relates to a kit for the care of keratin materials, comprising 1) a first composition comprising: at least one water-insoluble polyvalent metal salt; and 2) a second composition comprising at least one aqueous phase, and a) optionally, at least one water-soluble polyvalent metal ion sequestering agent, and b) at least one water-soluble gelling agent that is gellable with polyvalent metal ions; and 3) at least one water soluble carbonate or bicarbonate salt added to the first composition or the second composition, or both.

Description

Kit for skin care

Technical Field

The invention relates to an alginic acid system, in particular to an alginic acid kit for skin care. Furthermore, the invention relates to the use thereof, in particular as a mask for caring for keratin materials, in particular the skin.

Background

Providing consumers with highly effective products with skin benefits such as moisturizing, whitening, cleansing, etc., is a constant ultimate goal in the cosmetic field.

Generally, there are four types of facial masks, i.e., paste type, peel type, gel type, and wet tissue type facial masks. Among them, paste type and peel-off type masks are mainly used for cleansing keratin materials, while gel type and wet tissue type masks are more commonly used for skin care. It is known that gel type masks have good adhesion to the skin and can provide good freshness, however, moisturizing or hydrating effect to the skin may be insufficient, while wet tissue type masks are good at providing moisturizing and hydrating effect but absorb moisture back if applied for an extended period of time. In addition, adhesion to the skin may not be as good as a gel-type mask.

Carbonates or bicarbonates have been used in facial masks to generate carbon dioxide upon mixing with an acid to enhance blood circulation of the skin. Meanwhile, it is known that some water-soluble active agents are generally less stable in a solvated state, e.g., in aqueous solution, than in their dry form, thereby affecting their cosmetic effects. For example, some water-soluble vitamins, such as ascorbic acid (also known as vitamin C), react more readily in aqueous solution. In particular, at lower or higher pH, vitamin C tends to hydrolyze.

Based on the foregoing, there is a need for a new mask that integrates two or more of the advantages exhibited by known mask types, but does not suffer from one or more of the problems associated therewith.

Object of the Invention

Thus, in one aspect, it is an object to provide a mask that is capable of texture conversion, e.g., from a paper towel to a gel, thereby creating a pleasant consumer experience.

On the other hand, it is an object to provide a mask having a moisture or active transport capacity at least equivalent to or even greater than that observed for wet-wipe type masks.

On the other hand, it is an object to provide a mask having good adhesion to the skin and providing a refreshing feeling, like a gel-type mask.

In another aspect, it is an object to provide a mask that can bring about enhanced blood circulation to a keratin material over an extended period of time.

On the other hand, it is an object to provide a mask which brings about an improved whitening effect to keratin materials.

On the other hand, it is an object to provide a mask that integrates all the benefits described in the previous aspects.

On the other hand, the inventors have found that the concept or gist of the present invention is applicable not only to the cosmetic field but also to other fields such as the medical field, and the mask of the foregoing aspect can be extended to a kit which also shows the benefits described herein in connection with these masks.

Disclosure of Invention

The inventors have found a specific combination of: 1) a first composition comprising at least one water-insoluble polyvalent metal salt as an ion donor for a polyvalent metal; 2) a second composition comprising at least one aqueous phase, and a) optionally, at least one water-soluble polyvalent metal ion sequestering agent, and b) at least one water-soluble gelling agent that is gellable with polyvalent metal ions, one or more of the above requirements being met; and 3) at least one water soluble carbonate or bicarbonate component.

Accordingly, it is a subject of the present invention to provide a kit comprising a first composition and a second composition placed separately from each other.

Therefore, another subject of the present invention is a kit comprising a first composition and a second composition placed separately from each other, wherein component 3), namely: at least one water soluble carbonate or bicarbonate is added to the first and/or second composition.

Another subject of the present invention is the use of a second composition as a sap or partial sap of a mask product, wherein the mask product comprises a tissue separate from the second composition, the tissue comprising at least one water-insoluble polyvalent metal salt according to the present invention.

Another subject of the invention is the use of a kit according to the invention for caring for keratin materials, in particular the skin. This use may be represented by a method for caring for keratin materials, in particular the skin, comprising the following steps: the first and second compositions of the kit are mixed in a predetermined weight ratio and the mixture thus obtained is then applied to the keratin materials.

Another subject of the invention is the use of the kit according to the invention for treating skin wounds, for preventing post-operative adhesion formation or for filling or repairing osteochondral defects and the like. This use may be manifested as a method of treating a skin wound, preventing post-operative adhesion formation, or filling or repairing an osteochondral defect, comprising the steps of: the first and second compositions of the kit are mixed in a predetermined weight ratio and then applied to the site where the mixture thus obtained is desired.

Other characteristics and advantages of the invention will appear more clearly on reading the description and the examples which follow.

Detailed Description

Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term "about" meaning within 10% of the number indicated (e.g., "about 10%" indicates 9% to 11%, "about 2%" indicates 1.8% to 2.2%).

The articles "a" and "an" as used herein mean one or more when applied to any feature in embodiments of the present invention described in the specification and claims. The use of "a" and "an" does not limit the meaning to a single feature unless such a limit is explicitly stated. The articles "the" preceding singular or plural nouns or noun phrases denotes a particular specified feature or particular specified features and may have a singular or plural connotation depending upon the context in which it is used. The adjective "any" means one, some, or indiscriminately of all in any number.

The term "comprising" (and grammatical variants thereof) as used herein is used in an inclusive sense of "having" or "including," and not in an exclusive sense of "consisting only of. Nevertheless, for embodiments capable of being carried out in the form of "comprising", the skilled person will undoubtedly appreciate that the forms "consisting essentially of … …" and "consisting of … …" are naturally modifications of embodiments, and are within the scope of the present invention.

All percentages and ratios are by weight unless otherwise indicated. All percentages are based on the total weight of the composition, unless otherwise indicated. All components or compositions are referenced on an average to the active level of the component or composition and do not include impurities, such as residual solvents or by-products, which may be present in commercially available sources.

Preferably, the "keratin material" according to the invention is the skin. We use "skin" to denote all body skin. More preferably, the keratin material is the face or neck, especially the face.

By "topical application" is meant that the composition is applied or spread onto the surface of the keratin material, such as at least one area of the skin.

"alkali metal" means an element from group IA of the periodic Table of the elements, such as sodium, potassium, lithium or combinations thereof, preferably sodium, potassium or combinations thereof.

The term "water-soluble or water-dispersible" refers to compounds which, when introduced into water at 25 ℃ in a concentration by mass equal to 1%, make it possible to obtain a macroscopically homogeneous and transparent solution, i.e. a solution having a maximum light transmission value of at least 60% and preferably at least 70% through a 1cm thick sample at a wavelength equal to 500 nm.

In this application, unless specifically mentioned otherwise, the contents, parts and percentages are expressed on a weight basis.

According to the invention, the kit comprises a first composition and a second composition.

First composition

First, the first composition according to the invention comprises at least one water-insoluble polyvalent metal salt.

Water-insoluble polyvalent metal salt

The term "water-insoluble" means that the salt is insoluble in water, e.g. has a solubility of less than 0.01g/100g of water, or only slightly soluble, e.g. has a solubility of less than 0.5g/100g of water, and also does not disintegrate in a lumpy state when immersed in water.

In particular, the at least one water-insoluble multivalent metal salt may be present in the form of a powder, granules, fibers or agglomerates.

For the purposes of the present invention, the term "particle" when used with respect to a water-insoluble polyvalent metal salt means that the salt is in particulate form.

In particular, the water-insoluble polyvalent metal salt may be formed from an acid anion and a polyvalent metal cation, especially calcium, strontium, zinc, copper, manganese, aluminum or mixtures thereof. The useful metal is preferably calcium, copper or a mixture thereof, more preferably calcium.

The acid providing the acid anion according to the present invention may be any known acid useful in cosmetic products, provided that the salt formed from the acid and the polyvalent metal is not soluble or sparingly soluble in water. Typical acids which may be used include various inorganic acids, such as sulfates, carbonic acid, phosphoric acid meta-aluminates, silicic acid, and various organic acids, especially higher saturated or unsaturated fatty acids, especially those having 18 or more carbon atoms, such as stearic acid and oleic acid, or polycarboxylic acids, especially alginic acid, oxalic acid, for example, as long as the salts formed are not or only slightly soluble in water.

More specifically, the at least one water-insoluble polyvalent metal salt may be a sulfate or alginate, preferably selected from calcium sulfate/alginate, strontium sulfate/alginate, zinc sulfate/alginate, copper sulfate/alginate, manganese sulfate/alginate, or mixtures thereof, preferably calcium sulfate/alginate or copper sulfate/alginate, in particular calcium sulfate/alginate.

The term "alginate" refers in particular to salts of alginic acid. Alginic acid, a natural substance obtained from brown algae or certain bacteria, is a polyuronic acid composed of two uronic acids linked together by a 1, 4-glycosidic bond: beta-D-mannuronic acid (M) and alpha-L-glucuronic acid (G).

Water-insoluble alginates in which the main cation is calcium, particularly of the class PhaeophyceaeExamples of the leaves and stems of seaweeds include Fucus vesiculosus (Fucus vesiculosus)Fucus vesiculosus) Spirulina, spirulina (2)Fucus spiralis) Ascophyllum nodosum (Ascophyllum nodosum.)Ascophyllum nodosum) Giant kelpMacrocystis pyrifera) Winged algae (c)Alaria esculenta) Red algae (Xinghong algae) (Xinghong algae)Eclonia maxima), Lessonia nigrescens (Lessonia nigrescens)) Leptospira interrogans (Leptospira), Leptospira interrogans (Leptospira interrogans)Lessonia trabeculata) Sea tangle (A)Laminaria japonica) Antarctic Pleurotus ostreatus (A. clarkii)Durvillea antarctica), northern sea-tangle (Laminaria) hyperborea)、Brown algae of long Strongylocentrotus (A)Laminaria longicruris) Laminaria digitata (Laminaria digitata)Laminaria digitata)、Sugar sea tangle (Laminaria saccharina)、Kelps kelp(Laminaria cloustoni)And gulfweed: (Saragassum sp)。

Suitable water insoluble alginates have a weight average molecular weight of about 20,000 daltons to about 500,000 daltons. The Weight average Molecular Weight is calculated by first determining the intrinsic viscosity and then using the Mark-Houwink Sakurad equation, as in Martinsen et al, "Complex of Differencen Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates" (Carbohydr. Polymer., 15, 171-.

Superabsorbent material

According to one embodiment of the invention, the first composition may comprise at least one superabsorbent material.

In particular, the at least one superabsorbent material may be present in the form of a powder, granules, fibres or agglomerate state.

The superabsorbent materials advantageously exhibit a very strong capacity to absorb liquids, in particular water. In particular, it may exhibit a capacity to absorb 15 times, even 20 times to 50 times, for example about 25 times to 30 times, its own weight in water.

The capacity of the superabsorbent material to absorb liquid can be determined by carrying out the following method.

In the dry state (M)_D) Samples of superabsorbent material in the powder, fiber or agglomerate state or arranged as a film or sheet are weighed down. For example, a nonwoven square having an edge length of about 1 centimeter (cm) can be usedForming a net. In the context of the present process, the superabsorbent material is obtained in a "dry" state by treatment in a drying oven at about 50 ℃ for about 4 hours (h).

Water (or any other liquid to be absorbed by the material) is brought into contact with the material. This can be done by immersing the material in a liquid or by pouring a liquid over the material. For example, the material may be immersed for a duration of about 1 minute (min).

For example, the amount of water (or liquid) is used in excess in order to fully saturate the material. The excess water (or liquid) is then removed, for example by dripping dry for about 2 minutes, and the material (M) saturated in liquid is weighed_L)。

The difference Δ between the weight of the material when saturated in liquid and the weight of the material when dry represents the amount of liquid it absorbs, this weight being compared with the dry weight of the material. The resulting value C represents the capacity of the superabsorbent material to absorb liquid, for example in grams of liquid absorbed per gram of dry material:

the superabsorbent material may be selected from cellulose derivatives, alginates (excluding water insoluble alginates and alkali metal alginic compounds described herein as water soluble gelling agents) and derivatives thereof, particularly derivatives such as propylene glycol alginate or salts thereof, derivatives of polyacrylic or polymethacrylic acid, derivatives of poly (meth) acrylamide, derivatives of polyvinylpyrrolidone, derivatives of polyvinyl ethers, mixtures thereof and the like.

In particular, the superabsorbent material may be selected from chemically modified cellulose derivatives. For example, it may be selected from carboxymethyl cellulose, sodium carboxymethyl cellulose, carboxymethyl hydroxyethyl cellulose, carboxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl methyl cellulose, sodium methyl cellulose, microcrystalline cellulose, sodium cellulose sulfate and mixtures thereof.

It may also be selected from alkyl celluloses. These polymers are obtained by grafting alkyl residues onto one or more hydroxyl groups of the cellulose polymer to form hydroxyalkyl derivatives. These alkyl residues may be selected from the following group: stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl, palmityl, oleyl, linolenyl, ricinoleyl, behenyl and mixtures thereof. These hydroxyalkyl cellulose derivatives may also be subjected to chemical modification, for example with carboxyl residues.

The superabsorbent materials may also be selected from natural polymeric derivatives such as gellan gum and glucomannan and galactomannan polysaccharides extracted from seeds, plant fibers, fruits, seaweed, starch, plant resins or indeed microbial sources. For example, it may be selected from agar gum, guar gum, tragacanth gum, carrageenan, konjac gum, locust bean gum, gellan gum, xanthan gum and mixtures thereof.

In particular, the first composition of the invention may comprise at least one superabsorbent material in a content ranging from 0% to 80% by weight, in particular from 50% to 80% by weight, or even the remaining amount, relative to the total weight of the first composition.

According to one embodiment of the invention, in particular for facial mask use, the first composition further comprises further fibers in addition to fibers formed from at least one water-insoluble multivalent metal salt, wherein the at least one water-insoluble multivalent metal salt and optionally at least one carbonate or bicarbonate salt are loaded onto the further fibers.

According to one embodiment, the water-insoluble multivalent metal salt may be present in the form of fibers. The fibers of the at least one water-insoluble multivalent metal salt may then form a water-insoluble substrate, either alone or in combination with one or more other fibers. The carbonate or bicarbonate is optionally loaded onto the substrate.

Water insoluble substrate

For the purposes of the present invention, the term "water-insoluble" means that the substrate is insoluble in water and does not decompose when immersed in water.

In general, the substrate may be a woven or nonwoven fabric made from fibers of the at least one water-insoluble multivalent metal salt (hereinafter also referred to as water-insoluble multivalent metal salt fibers) together with at least one other fiber selected from the group consisting of: natural fibers such as cotton, pulp, bamboo and cellulose fibers, semi-natural fibers such as viscose rayon fibers, synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers. Two or more kinds selected from other fibers may be used in combination.

The substrate may be formed in a variety of shapes and forms, such as flat pads, thick pads, thin sheets of irregular thickness, depending on the desired use and characteristics of the kit. By way of example only, in the case of a mask that requires topical application, the substrate is typically designed to fit the area of skin. For this reason, when the mask is applied to the face, the substrate is designed to correspond to the shape of the face as needed, avoiding the eyes, nostrils, and mouth area. Non-limiting examples of substrates that can be used in the present invention are described in, for example, patent application WO 02/062132 or EP 2489286 a.

In particular, the water-insoluble substrate or fabric may comprise water-insoluble polyvalent metal salt fibers, in particular calcium alginate fibers, in a content ranging from 10% to 100% by weight, or from 10% to 80% by weight, in particular from 10% to 40% by weight, relative to the total weight of the water-insoluble substrate or fabric. Accordingly, the water insoluble substrate or fabric may comprise at least one further fibre in an amount ranging from 10 to 80 wt. -%, in particular from 50 to 80 wt. -%, relative to the total weight of the water insoluble substrate or fabric.

More particularly, suitable nonwoven fabrics comprising calcium alginate fibers are commercially available from Sanjiang corporation under the designation M762R-40 CN.

The kit according to the invention comprises a second composition separate from the first composition (e.g. water-insoluble substrate). The second composition is impregnated, coated or otherwise contacted with the first composition as desired to convert the texture of the first composition, for example, from a tissue to a gel.

Preferably, for sufficient texture transformation, the weight ratio of the first composition (e.g. water insoluble substrate or fabric) to the second composition ranges from 1:3 to 1:20, preferably from 1:8 to 1: 15.

Second composition

The second composition of the invention comprises at least a) optionally, at least one water-soluble polyvalent metal ion chelating agent and b) at least one water-soluble gelling agent, which is gellable with said polyvalent metal ion.

According to the invention, when the first and second compositions are mixed, the water-insoluble polyvalent metal ion donor reacts with the salt in solution and releases the polyvalent metal ion. When the second composition does not comprise component a), i.e.: the at least one water-soluble polyvalent metal ion chelating agent, the polyvalent metal ions released into solution with component b), i.e.: the at least one water-soluble gelling agent is reacted directly. When the second composition comprises component a), most of the polyvalent metal ions released into the solution will be captured by the water-soluble chelating agent. A small amount of free polyvalent metal ions in the solution reacts with the water-soluble gelling agent and starts to gel on the surface of the tissue. As the concentration of free polyvalent metal ions decreases over time, the chelated polyvalent metal ions will be gradually released and then gel on the surface of the tissue. After a short period of time, a transition in the tissue texture and a homogeneous gel on the tissue surface will be observed.

Polyvalent metal ion chelating agent

The second composition according to the invention optionally comprises component a), i.e.: at least one water-soluble polyvalent metal ion chelating agent to promote texture transformation and, in particular, to at least enhance the moisture or active transport capacity. The water-soluble polyvalent metal ion chelator is water-soluble.

According to the present invention, the water insoluble polyvalent metal ion donor releases a small amount or more of polyvalent metal ions into a solution when the first composition is mixed with a second composition comprising component a). The polyvalent metal ion chelating agent and the water-soluble gelling agent are each capable of binding a polyvalent metal ion.

Surprisingly, the specific chelating agent according to the invention competes with the gelling agent in competition for binding to the polyvalent metal ion, such that a large part of the polyvalent metal ion released is captured by the water-soluble chelating agent. A small amount of free polyvalent metal ions still present in the solution reacts with the water-soluble gelling agent and starts to gel on the surface of the tissue. As the concentration of free polyvalent metal ions decreases over time, the chelated polyvalent metal ions will be gradually released and then gel on the surface of the tissue. That is, the specific chelating agent according to the invention acts as a reservoir for polyvalent metal ions for gelling on the tissue surface.

Useful polyvalent metal ion chelating agents according to the present invention include aminocarboxylic acids such as ethylenediaminetetraacetic acid (EDTA), aminotriacetic acid, diethylenetriaminepentaacetic acid, and particularly alkali metal salts thereof such as N, N-bis (carboxymethyl) glutamic acid, tetrasodium EDTA, tetrasodium N, N-bis (carboxymethyl) glutamic acid (glutamic diacetic acid, GLDA); hydroxycarboxylic acids such as citric acid, tartaric acid, glucuronic acid, succinic acid, ethylenediamine disuccinic acid (EDDS), and particularly alkali metal salts thereof; hydroxyaminocarboxylic acids, such as hydroxyethylethylenediaminetriacetic acid (HEDTA), Dihydroxyethylglycine (DEG), and in particular alkali metal salts thereof; polyphosphonic acids, and in particular alkali metal salts thereof; other phosphorus-containing organic acids, for example phytic acid and in particular the alkali metal salts thereof, for example sodium phytate, potassium phytate, polycarboxylic acids, for example polyacrylic acid, polymethacrylic acid and in particular the alkali metal salts thereof.

In one embodiment, the at least one water-soluble polyvalent metal ion chelating agent is an alkali metal hydroxypolycarboxylate represented by an alkane containing 1 to 4 carbon atoms, preferably 2 or 3 carbon atoms, substituted by 1,2 or 3 hydroxyl groups (-OH), preferably by one (1) hydroxyl group, and further substituted by 2,3, 4 or 5 carboxylate groups (-COOM), preferably by 2 or 3 carboxylate groups (-COOM), wherein the plurality of groups M independently represent H or an alkali metal, with the proviso that at least one of the groups M represents an alkali metal, such as Na, K or Li, preferably all groups M represent an alkali metal, such as Na, K or Li, preferably Na. More particularly, the at least one alkali metal hydroxypolycarboxylate may be selected from sodium tartrate, sodium citrate, potassium tartrate, potassium citrate and hydrates thereof, preferably sodium citrate, in particular trisodium citrate. Herein, sodium citrate is used to denote monosodium citrate, disodium citrate, and trisodium citrate, and other alkali metal hydroxypolycarboxylates may be similarly understood.

Among them, the above-mentioned alkali metal is preferably sodium or potassium, especially sodium. Thus, preferred chelating agents may include sodium citrate, tetrasodium EDTA, tetrasodium GLDA, trisodium EDDS, sodium phytate, or mixtures thereof.

In particular, the second composition of the invention may comprise at least one water-soluble polyvalent metal ion chelating agent in a content ranging from 0.1% to 1% by weight, in particular from 0.2% to 0.4% by weight, relative to the total weight of the second composition.

Water-soluble gelling agent

The second composition according to the invention comprises at least one water-soluble gelling agent which can gel with the polyvalent metal ion to trigger the texture transformation.

In the present application, the term "water-soluble gelling agent" specifically denotes one that can gel with the polyvalent metal ion from the first composition.

According to the present invention, the water-insoluble polyvalent metal ion donor releases a small amount or more of polyvalent metal ions into a solution when the first composition is mixed with the second composition.

The gelling agent may thus be any that can gel with a polyvalent metal ion, in accordance with the principles of the present invention. Examples of such gelling agents may include gelatin, pectin, gellan gum, carrageenan, agar, alginic compounds, and in particular alkali metal salts of alginic acid, such as sodium alginate, and mixtures thereof. When the second composition comprises component a), i.e. a chelating agent, the gelling agent and the chelating agent are especially selected wherein the binding capacity of the gelling agent to the polyvalent metal ion is lower than the binding capacity of the chelating agent, such that the gelling agent does not bind to free polyvalent metal ions released directly from the first composition, but to polyvalent metal ions subsequently coming from the reservoir, i.e. chelated polyvalent metal ions. Thus, a gel may be formed on the surface of the first composition.

Pectin is a linear polymer of alpha-D-galacturonic acid (at least 65%) attached in the 1 and 4 positions to a proportion of carboxyl groups esterified with carbinol groups. About 20% of the sugars constituting the pectin molecule are neutral sugars (L-rhamnose, D-glucose, D-galactose, L-arabinose, D-xylose). L-rhamnose residues are present in all pectins and are incorporated into the backbone at the 1,2 positions.

The uronic acid molecule carries a carboxyl function. When the pectin is COO^-In form, this functional group confers the pectin the ability to exchange ions. Divalent ions (particularly calcium ions) have the ability to form an ionic bridge between the two carboxyl groups of two different pectin molecules.

In the natural state, a certain proportion of the carboxyl groups are esterified with methanol groups. Depending on the source used, the natural degree of esterification of the pectin may be between 70% (apple, lemon) and 10% (strawberry). Hydrolysis of-COOCH Using highly esterified pectin₃And (c) removing groups, thereby obtaining the weakly esterified pectin. Depending on the proportion of methylated or unmethylated monomers, the chain is therefore more or less acidic. HM (high methoxyl) pectin is thus defined as having a degree of esterification of more than 50% and LM (low methoxyl) pectin is defined as having a degree of esterification of less than 50%.

In the case of amidated pectins, -OCH₃radical-NH₂And (4) substituting the group.

Pectin is sold in particular by the company Cargill under the name Uninectine ™, by the company CP-Kelco under the name Genu, and by the company Danisco under the name Grinsted Pectin.

Carrageenans are anionic polysaccharides that constitute the cell walls of various red algae (class rhodophyceae) belonging to the families Gigartinaceae (Gigartinaceae), Sargassaceae (Hypaeae), Furceriaceae (Furcellarae) and Polyideaceae (Polyideaceae). They are generally obtained by hot aqueous extraction from natural strains of said algae. These linear polymers formed from disaccharide units consist of two D-galactopyranose units alternately linked by α (1,3) and β (1,4) bonds. They are highly sulfated polysaccharides (20-50%) and the α -D-galactopyranose residues may be in the 3, 6-anhydro form. Depending on the number and position of sulfate groups on the repeating disaccharide of the molecule, several types of carrageenans can be distinguished, namely: kappa-carrageenan, which carries one sulfate group, iota-carrageenan, which carries two sulfate groups, and lambda-carrageenan, which carries three sulfate groups.

Carrageenan is mainly composed of potassium, sodium, magnesium, triethanolamine and/or calcium salts of polysaccharide sulfate.

Carrageenan is in particular sold under the name Solagum by the company SEPPIC^®The company Gelymar under the name Carragel^®、Carralact^®And Carrasol^®The name Satiagel and Satiaglum ™ by Cargill, and the name Genulacta by CP-Kelco^®、Genugel^®And Genuvisco^®And (4) selling.

Agar is a galactose polysaccharide contained in the cell wall of some species in these red algae (family rhodophytaceae). They are formed of polymer groups whose basic skeletons are β (1,3) D-galactopyranose and α (1,4) L3-6 anhydrogalactan chains, these units being regularly repeated alternately. The differences within the agarase family are due to the presence or absence of solvated methyl or carboxyethyl groups. These confounding structures are usually present in variable percentages, depending on the species of algae and the harvest season.

The agar has a viscosity of between 40000 and 300000 g.mol^-1A mixture of high molecular weight polysaccharides (agarose and agar). It is obtained by making an algae extract, generally by high-pressure treatment, and by treating these liquids containing about 2% agar, to extract the latter.

For example, Agar is manufactured by the B & V Agar products group Hispanagrar company under the names Gold Agar, and Grand Agar, and Setexam company under the names Agar-Agar, QSA (instant Agar), and Puragar.

Gellan gum is an anionic linear heteropolyglycoside based on oligoglycoside units consisting of 4 sugars (tetraglycosides). D-glucose, L-rhamnose and D-glucuronic acid are present in gellan gum as monomeric units in a ratio of 2:1: 1.

For example, it is sold under the name kellogel CG LA by CP Kelco.

In one embodiment of the invention, the gelling agent is preferably selected from alkali metal alginates. Particularly preferred gelling agents are alginates, such as sodium alginate or potassium alginate, especially sodium alginate.

According to one embodiment, the at least one water-soluble gelling agent is present in the second composition in a range from 0.1% to 0.5% by weight, preferably from 0.1% to 0.3% by weight, relative to the total weight of the second composition.

According to the invention, the amounts of chelating agent and gelling agent are selected such that the molar ratio of the fraction released from the chelating agent that can be chelated with multivalent cations to the fraction released from the gelling agent that can be gelled with multivalent cations ranges from about 10:1 to about 1:1, preferably from about 5:1 to about 2: 1.

Alkali metal alginic acid compounds

The term "alkali metal alginic acid compound" especially refers to alkali metal alginates (alginates) or alkali metal salts of alginic acid derivatives. The alkali metal alginic acid is water soluble.

Alginic acid, a natural substance obtained from brown algae or certain bacteria, is a polyuronic acid composed of two uronic acids linked together by a 1, 4-glycosidic bond: beta-D-mannuronic acid (M) and alpha-L-glucuronic acid (G).

Alginic acid is capable of forming water soluble salts (alginates) with alkali metals such as sodium, potassium or lithium. These alginates are water soluble at pH 4 in aqueous media, but break down to alginic acid at pH below 4.

Methods for recovering these water soluble salts, particularly sodium alginate, from natural sources are well known and described, for example, in U.S. patent No. 2,036,934 to Green and U.S. patent No. 2,128,551 to Le Gloahec.

Alginic acid or alginates may be chemically modified, especially with urea or urethane groups or by hydrolysis, oxidation, esterification, etherification, sulphation, phosphorylation, amination, amidation or alkylation reactions, or by several of these modifications, to form alginic acid derivatives, including salts.

These derivatives may be anionic, cationic, amphoteric or nonionic and are capable of forming water soluble salts with alkali metals such as sodium, potassium or lithium to form the alkali metal salts of alginic acid derivatives.

More specifically, alginates may be reacted with alkylene oxides, such as ethylene oxide or propylene oxide, to form polyethylene glycol alginates. The polyethylene glycol segment is bound to the alginate via the carboxyl group(s). Typically, alginates react with propylene oxide to form polypropylene glycol alginate (PPG alginate) and with ethylene oxide to form polyethylene glycol alginate (PEG alginate). Preparation of polyethylene glycol alginate is disclosed in Strong U.S. patent No. 3,948,881, Pettitt U.S. patent No. 3,772,266 and Steiner U.S. patent No. 2,426,125.

Preferably, the polyethylene glycol alginate has a degree of esterification of from about 40% to about 95%, more preferably from about 70% to 95%.

Suitable alginates have a weight average molecular weight of about 20,000 daltons to about 500,000 daltons. The Weight average Molecular Weight is calculated by first determining the intrinsic viscosity and then using the Mark-Houwink Sakurad equation, as in Martinsen et al, "Complex of Differencen Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates" (Carbohydr. Polymer., 15, 171-.

The above weight average molecular weight is also effective for alkali metal salts of alginic acid derivatives.

A listing of various commercially available alginates, their properties, and their sources is found in U.S. patent No. 6,334,968 to Shapiro, table 1, column 16, line 49, to column 17, line 18, incorporated herein by reference.

According to one embodiment of the invention, the alkali metal alginic compound may be selected from sodium alginate and potassium alginate, preferably sodium alginate.

Alkali metal alginates suitable for use in the present invention may be represented, for example, by the names Kelcosol, Satialgine, Cecalgum or Algogel manufactured by Cargill Products, FMC Biopolymer manufactured by Protanal, Danisco manufactured by Grindsted alginate, Kimica manufactured by Kimica Algin, and ISP manufactured by Manucol and Manugel.

Aqueous phase

The second composition according to the invention comprises at least one aqueous phase.

The at least one aqueous phase comprises water.

The aqueous phase may also comprise a water-miscible organic solvent (at room temperature: 25 ℃), for example a monohydric alcohol containing from 2 to 6 carbon atoms, such as ethanol or isopropanol; polyols, in particular having from 2 to 10 carbon atoms, preferably from 2 to 10 carbon atoms and preferably from 2 to 6 carbon atoms, such as glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol or diethylene glycol; glycol ethers (especially containing 3 to 16 carbon atoms) such as mono-, di-or tri-propylene glycol (C)₁-C₄) Alkyl ethers, mono-, di-or tri-ethylene glycols (C)₁-C₄) Alkyl ethers, and mixtures thereof.

The aqueous phase may also comprise any water-soluble or water-dispersible compound compatible with the aqueous phase, such as hydrophilic gelling agents, preservatives or surfactants and mixtures thereof.

In particular, the second composition of the invention may comprise at least one aqueous phase in a content ranging from 10% to 99% by weight, in particular from 50% to 99% by weight and more particularly from 70% to 99% by weight relative to the total weight of the second composition.

Acidic reagent

For releasing CO from carbonate (hydr) in a kit₂The kit comprising the first and second compositions according to the invention further comprises an acidic reagent. The acidic reagent is mixed with a carbonate (hydrogen) in a solution state, and then reacts with the carbonate (hydrogen) to release carbon dioxide.

For the purposes of the present invention, "acidic agent" means any cosmetically permissible one having a pH in solution of less than 7 capable of reacting with the (bi) carbonate used in the kit.

Useful acidic agents may be inorganic or organic acids. Preferably, the acidic agent is at least one organic acid selected from the group consisting of: formic acid, acetic acid, propionic acid, butyric acid, valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, terephthalic acid, glutamic acid, aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropine acid, ascorbic acid, and gluconic acid; or inorganic acids such as phosphoric acid; an acidic derivative thereof or a mixture thereof.

Among them, acids generally used as active agents or adjuvants in cosmetics are preferably used. For example, amino acids, tartronic acid, salicylic acid, gallic acid, tropine acid, ascorbic acid and gluconic acid are preferably used. Such an acid or a mixture thereof may then be used both as an agent or adjuvant and as an acidic agent releasing carbon dioxide from the (bi) carbonate.

For the purposes of the present invention, an acidic agent may be added to the second composition. Thus, the acid is dissolved into the aqueous phase of the second solution. When a second composition, placed separately from the first composition, is brought into contact with the first composition before use, the acid reacts with the (bi) carbonate.

For the purposes of the present invention, an acidic agent may be added to the first composition. Thus, it is preferred to use the acid in solid form, for example in the form of particles. The acidic agent is then preferably selected from oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, terephthalic acid, glutamic acid, aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropine acid, ascorbic acid, gluconic acid.

For the purposes of the present invention, the compositions of the invention are particularly suitable for the use of acidic reagents which are unstable in the solvated state.

For the purposes of the present invention, "unstable" means that the ingredient or composition undergoes a significant change in its structure or properties within 2 months, or preferably within 1 month, of the solvent or solvated state. Such a change may be any one that is undesirable for cosmetic use, including but not limited to a color change, degradation, decomposition, reaction with other substances, significant evaporation, deposition, crystallization, and the like.

For such unstable acid reagents, they are added to the first composition in solid form. Among them, ascorbic acid is preferably used. ASCORBIC ACID suitable for use in the present invention may be represented, for example, by the product sold under the name ascobic ACID 100 MESH available from CSPC WEISHENG PHARMACEUTICAL or BASF.

Useful ascorbic acid derivatives preferably include 3-o-ethyl ascorbic acid, ascorbyl glucoside, or mixtures thereof.

According to the invention, the acidic agent is used in stoichiometric excess with respect to the (bi) carbonate, for example in a molar ratio of from 1.1:1 to 3:1, preferably from 1.2:1 to 2: 1. When the acidic agent is added to the first composition, the acidic agent is preferably used in an amount of 0.01 to 20%, preferably 0.1 to 15%, or preferably 0.2 to 10%, relative to the weight of the first composition.

Hydrophilic gelling agent

The second composition according to the invention may optionally comprise at least one additional hydrophilic gelling agent.

For the purposes of the present invention, the term "hydrophilic gelling agent" refers to a compound capable of gelling the aqueous phase without binding polyvalent metal ions from the first composition.

The gelling agent may be water soluble or water dispersible.

More specifically, the hydrophilic gelling agent may be chosen from synthetic polymeric gelling agents, polymeric gelling agents of natural or natural origin, or mixtures thereof.

Synthetic polymer gelling agents

For the purposes of the present invention, the term "synthetic" means that the polymer is neither naturally occurring nor a derivative of a polymer of natural origin.

Synthetic polymeric gelling agents contemplated according to the present invention may or may not be particles.

For the purposes of the present invention, the term "particles" when used in the synthesis of polymeric gelling agents means that the polymers are in the form of particles, preferably spherical particles.

More specifically, these polymers may be chosen in particular from:

modified or unmodified carboxyvinyl polymers, such as the products sold under the name Carbopol (CTFA name: Carbomer) by the company Goodrich; polyacrylates, polymethacrylates such as those sold under the names Lubrajel @andNorgel by Guardian corporation or under the names Hispagel @byHispano Chimica corporation; polyacrylamide; optionally crosslinked and/or neutralized 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers, such as poly (2-acrylamido-2-methylpropanesulfonic acid)

Clariant Inc. sells under the name Hostacerin AMPS (CTFA name: Polyacryloyldimethyl ammonium taurate); crosslinked anionic copolymer of acrylamide and AMPS in the form of a W/O emulsion, for example Sepigel ™ 305(CTFA name: polyacrylamide/C) by the company SEPPIC_13-14Isoparaffin/laureth-7) and the peptide fragment of the invention designated as Simulgel ™ 600(CTFA name: acrylamide/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate 80); and mixtures thereof.

Preferably, these polymers may be selected from acrylates/C_10-30Alkyl acrylate crosslinked polymers, such as Carbopol ultrez 20, Carbopol ultrez 21, Permulen TR-1, Permulen TR-2, Carbopol 1382, Carbopol ETD 2020, carbomer, Synthalen K, Carbopol To, Acryloyldimethyl ammonium taurate/steareth-8 methacrylate copolymers, Aristoflex SNC, acrylate copolymers, such as Carbopol Aqua SF-1, Acryloyldimethyl ammonium taurate/steareth-25 methacrylate crosslinked polymers, such as Aristoflex HMS, Acryloyldimethyl ammonium taurate, such as Aristoflex AVC.

Preferably, these polymers may be chosen from carboxyvinyl polymers, such as Carbopol @products (carbomers), such as LubRizol commercial Carbopol Ultrez 20 Polymer and Pemulen products (acrylate/C)_10-30Alkyl acrylate copolymers); polyacrylamide, e.g. from SEPPIC under the trademark Sepigel 305(CTFA name: Polyacrylamide/C)_13-14Isoparaffin/laureth-7) or Simulgel^TM600(CTFA name: acrylamide/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate 80); 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers, optionally crosslinked and/or neutralized, such as poly (2-acrylamido-2-methylpropanesulfonic acid) sold by Hoechst under the trademark Hostacerin AMPS (CTFA name: ammonium polyacryloyldimethyltaurate) or Simulgel @ 800(CTFA name: sodium polyacryloyldimethyltaurate/polysorbate 80/sorbitan oleate) sold by SEPPIC; copolymers of 2-acrylamido-2-methylpropanesulfonic acid and hydroxyethyl acrylate, such as the Simulgel ™ NS and Sepinov EMT 10 sold by SEPPIC; and mixtures thereof.

Preferably, these polymers may be chosen from those known under the trade name Lubrajel^TMGlycerol acrylate/acrylic acid copolymer, in particular known as Lubrajel, available from ISP Technologies, Inc. (United Guardian Inc.)^TMIn the form of an oil containing about 1.0% to 1.3% of a glyceryl acrylate/acrylic acid copolymer in aqueous glycerol (about 40% glycerol). The Lubrajel oil also included about 0.6% of PVM/MA copolymer (also known as methoxyethylene/maleic anhydride copolymer).

Polymeric gelling agents of natural or natural origin

For the purposes of the present invention, the term "naturally derived" is intended to mean a polymeric gelling agent obtained by modifying a natural polymeric gelling agent.

These gelling agents may be particulate or non-particulate.

More specifically, these gelling agents fall into the category of polysaccharides.

Generally, the polysaccharides suitable for use in the present invention may be homopolysaccharides such as glycans, glucans, galactans and mannans or heteropolysaccharides such as hemicelluloses.

Similarly, they may be linear polysaccharides such as pullulan or branched polysaccharides such as gum arabic and pullulan, or mixed polysaccharides such as starch.

Generally, the polysaccharide may be selected from microbially produced polysaccharides; polysaccharides isolated from algae, and higher plant polysaccharides, such as homogenous polysaccharides, in particular cellulose and its derivatives or fructans, heterogeneous polysaccharides, such as gum arabic (gum arabic), galactomannans, glucomannans and their derivatives; and mixtures thereof.

In particular, the polysaccharide may be chosen from fructans, gellan, dextran, amylose, amylopectin, glycogen, pullulan, dextran, cellulose and its derivatives, in particular methylcellulose, hydroxyalkylcellulose, ethylhydroxyethylcellulose and carboxymethylcellulose, mannan, xylan, lignin, arabinons, galactans, polygalacturonic acid, chitin, chitosan, glucuronoxylomannan, arabinoxylans, xyloglucans, glucomannans, arabinogalactans, glycosaminoglycans, gum arabic, tragacanth gum, ghatti gum, locust bean gum, galactomannans such as guar gum and its non-ionic derivatives, in particular hydroxypropyl guar gum and its ionic derivatives, biopolysaccharide gums of microbial origin, in particular scleroglucan or xanthan gum, mucopolysaccharides, and in particular chondroitin sulphate, and mixtures thereof. These polysaccharides can be chemically modified, in particular with urea or urethane groups or by hydrolysis, oxidation, esterification, etherification, sulfation, phosphorylation, amination, amidation or alkylation reactions, or by several of these modifications.

The derivatives obtained may be anionic, cationic, amphoteric or nonionic.

Advantageously, the polysaccharide may be selected from xanthan gum, scleroglucan gum, guar gum, inulin and pullulan and mixtures thereof.

In general, compounds of this type which can be used in the present invention are selected from those described in particular below: Kirk-Othmer's Encyclopedia of Chemical Technology, 3 rd edition, 1982, volume 3, page 896-900, and volume 15, page 439-458, Polymers in Nature, John Wiley & Sons, Chapter 6, page 240-328, 1980, the work of Robert L, Davidson, entitled Handbook of Water-solvent Gums and Resins, McGraw Hill Book Company (1980), and Industrial Gums-Polymers and the oil Derivatives, Roy L. Whisted, 2 nd edition, Academic Press, Inc.

More specifically, these polysaccharides suitable for use in the present invention can be distinguished according to whether they are derived from microorganisms, algae or higher plants, and are described in detail below.

Microbially produced polysaccharides

Xanthan gum

Xanthan gum is a heteropolysaccharide produced by Xanthomonas campestris: (Xanthomonas campestris) The aerobic fermentation of (2) is produced on an industrial scale. Its structure consists of a β (1,4) -linked β -D-glucose backbone, similar to cellulose. One of the two glucose molecules carries a trisaccharide side chain consisting of alpha-D-mannose, beta-D-glucuronic acid and terminal beta-D-mannose. The internal mannose residue is typically acetylated at carbon 6. About 30% of the terminal mannose residues carry a pyruvate group attached in chelated form between carbons 4 and 6. The charged pyruvic and glucuronic acids are ionizable and therefore responsible for the anionic nature of xanthan gum (negative charge drops to a pH equal to 1). The contents of pyruvic acid and acetic acid residues vary depending on the strain, fermentation process, post-fermentation conditions and purification steps. These groups can be used as Na in commercial products⁺、K⁺Or Ca²⁺Ion neutralization (Satia Corp., 1986). The neutralized form can be converted to the acid form by ion exchange or by dialysis against an acidic solution.

For aqueous compositions containing 1% xanthan gum, the xanthan gum has a molecular weight of 1000000 to 50000000 and a viscosity of 0.6 to 1.65pa.s (measured at 60rpm on a Brookfield viscometer, LVT type at 25 ℃).

Xanthan gum is represented, for example, by the product sold under the name Rhodicare by Rhodia Chimie, the product sold under the name Satiaxan by Cargill texturing Solutions (for use in the food, cosmetic and pharmaceutical industries), the product sold under the name Novaxan @byADM company, and the product sold under the names Kelzan and Keltrol by CP-Kelco company.

Pullulan polysaccharide

Pullulan is a polysaccharide composed of maltotriose units known by the name α (1,4) - α (1,6) -glucan. Three glucose units in maltotriose are connected by α (1,4) glycosidic bonds, while successive maltotriose units are connected to each other by α (1,6) glycosidic bonds.

For example, Pullulan is produced by the Hayashibara group of japan with reference to Pullulan PF 20.

Dextran and dextran sulfate

Glucans are neutral polysaccharides without any charged groups, which are biologically inert and are prepared by fermentation of sugar beet which contain only hydroxyl groups. Dextran fractions of different molecular weights can be obtained from natural dextran by hydrolysis and purification. The dextran may especially be in the form of dextran sulphate.

For example, Dextran is represented by the products sold by Pharmacosmos company under the name Dextran or Dextran T, or Meito Sangyo Co. company under the name Dextran 40 Powder or Dextran 70 Powder. Dextran sulfate is sold under the name dextran sulfate by the company PK Chemical A/S.

Succinoglycans

Amber (Succinum)Acyl radicalGlycans are high molecular weight extracellular polymers produced by bacterial fermentation, consisting of octasaccharide repeat units (8 saccharide repeats). For example, amberAcyl radicalGlycans are sold under the name Rheozan by Rhodia. Scleroglucan

Scleroglucan is a non-ionic branched homopolysaccharide composed of β -D-glucan units. These molecules consist of a linear backbone formed by D-glucose units linked by β (1,3) bonds, and one third of them are linked to flanking D-glucose units by β (1,6) bonds.

A more complete description of scleroglucan and its preparation can be found in patent US 3301848.

For example, scleroglucan is produced by Alban MiilleCompany r is sold under the name Amigel or by the company Cargill under the name Actigum^TMAnd (4) selling the CS.

Polysaccharides isolated from algae

Danish agar

Denmark agar is commercially available from the red algae, the helminthic fork red algae (Furcellaria fasztigata). Danish Agar is produced, for example, by the company Est-Agar.

Higher plant polysaccharides

Such polysaccharides can be divided into homogeneous polysaccharides (only one saccharide) and heterogeneous polysaccharides consisting of several types of saccharides.

a) Homogeneous polysaccharides and derivatives thereof

The polysaccharide according to the invention may be selected from cellulose and derivatives or fructans.

Cellulose and derivatives

The polysaccharide of the invention may also be cellulose or a derivative thereof, especially a cellulose ether or ester (e.g. methyl cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethylpropyl cellulose, cellulose acetate, cellulose nitrate, nitrocellulose).

The present invention may also contain a cellulose-based associative polymer.

According to the present invention, the term "cellulose-based compound" refers to any polysaccharide compound bearing in its structure a linear sequence of anhydroglucopyranose residues (AGU) linked together by β (1,4) bonds. The repeating unit is a cellobiose dimer. AGU is in chair conformation and carries 3 hydroxyl functions: 2 secondary alcohols (at positions 2 and 3) and one primary alcohol (at position 6). The polymers thus formed are held together by intermolecular bonds of the hydrogen bond type, giving the cellulose a fibrillar structure (about 1500 molecules per fiber).

The degree of polymerization varies greatly depending on the source of the cellulose; which may range in value from hundreds to tens of thousands.

The hydroxyl groups of cellulose can be partially or completely reacted with various chemical reagents to obtain cellulose derivatives with inherent properties. The cellulose derivative may be anionic, cationic, amphoteric or nonionic. Among these derivatives, cellulose ethers, cellulose esters and cellulose ester ethers are distinguished.

Among the nonionic cellulose ethers, alkyl celluloses such as methyl cellulose and ethyl cellulose; hydroxyalkyl celluloses such as hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and the like; and mixed hydroxyalkyl alkylcelluloses such as hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose and hydroxybutyl methylcellulose.

Among the anionic cellulose ethers, mention may be made of carboxyalkyl celluloses and their salts. For example, carboxymethyl cellulose, carboxymethyl methyl cellulose and carboxymethyl hydroxyethyl cellulose and their sodium salts may be mentioned.

Among the cationic cellulose ethers, mention may be made of crosslinked or non-crosslinked quaternized hydroxyethyl cellulose.

The quaternizing agent may in particular be glycidyltrimethylammonium chloride or a fatty amine such as laurylamine or stearylamine. Another cationic cellulose ether that may be mentioned is hydroxyethyl cellulose hydroxypropyl trimethylammonium.

Quaternized cellulose derivatives are in particular:

quaternized cellulose modified with groups comprising at least one fatty chain, such as alkyl, aralkyl or alkaryl groups comprising at least 8 carbon atoms, or mixtures thereof,

-quaternized hydroxyethylcellulose modified with groups comprising at least one fatty chain, such as alkyl, aralkyl or alkaryl groups comprising at least 8 carbon atoms, or mixtures thereof.

The alkyl groups carried by the quaternized cellulose or hydroxyethyl cellulose described above preferably contain from 8 to 30 carbon atoms. The aryl group preferably represents a phenyl, benzyl, naphthyl or anthracenyl group.

May be indicated as containing C_8-30Examples of fatty chain quaternized alkyl hydroxyethyl celluloses include Quatrioft LM 200, Quatrioft LM-X529-18-A, Quatrioft LM-X529-18B (C) products sold by Amerchol₁₂Alkyl) and Quatrisoft LM-X529-8(C₁₈Alkyl), and the products Crodacel QM, Crodacel QL (C) sold by Croda corporation₁₂Alkyl) and Crodacel QS (C)₁₈Alkyl groups).

Among the cellulose derivatives, mention may also be made of:

cellulose modified with groups comprising at least one fatty chain, for example with groups comprising at least one fatty chain, such as alkyl, especially C_8-22Aralkyl and alkaryl modified hydroxyethylcelluloses, such as Natrosol Plus Grade 330 CS (C) sold by Aqualon₁₆Alkyl), and

cellulose modified with polyalkylene glycol alkylphenyl ether groups, such as the product Amercell Polymer HM-1500 (nonylphenylpolyethylene glycol (15) ether) sold by the company Amerchol.

Among the cellulose esters are inorganic esters of cellulose (cellulose nitrate, cellulose sulfate, cellulose phosphate, etc.), organic cellulose esters (cellulose monoacetate, cellulose triacetate, cellulose acylamidopropionate, cellulose acetate butyrate, cellulose acetate propionate, cellulose acetate trimellitate, etc.), and mixed organic/inorganic esters of cellulose, such as cellulose acetate butyrate sulfate and cellulose acetate propionate sulfate. Among the cellulose ester ethers, mention may be made of hydroxypropylmethylcellulose phthalate and ethylcellulose sulfate.

The cellulose-based compound of the present invention may be selected from unsubstituted cellulose and substituted cellulose. The cellulose and derivatives are represented by products such as those sold as follows: FMC Biopolymers Inc. are under the name Avicel (microcrystalline cellulose, MCC), Noviant Inc. (CP-Kelco) under the name Cekol (carboxymethylcellulose), Akzo Nobel company under the name Akucell AF (carboxymethylcellulose sodium), Dow company under the name Methocel (cellulose ether) and Ethocel (ethylcellulose), and Hercules Aqualonn Inc. under the name Aqualon (carboxymethylcellulose and carboxymethylcellulose sodium), Benecel (methylcellulose), Blanose (carboxymethylcellulose), Culminal (methylcellulose, hydroxypropylmethylcellulose), Klucel (hydroxypropylcellulose), Polysurf (cetylhydroxyethylcellulose) and Natrosol CS (hydroxyethylcellulose).

Fructosan

The polysaccharide according to the invention may in particular be a fructan selected from inulin and its derivatives (in particular dicarboxy and carboxymethyl inulin).

Fructans or Fructans (Fructans or Fructans) are oligosaccharides or polysaccharides that contain a series of anhydrofructose units, optionally in combination with several sugar residues other than fructose. The fructans may be linear or branched. Fructans can be products obtained directly from plant or microbial sources, or products whose chain length has been altered (increased or decreased) by fractionation, synthesis or hydrolysis, in particular enzymatically. Fructans typically have a degree of polymerization of 2 to about 1000, and preferably 2 to about 60.

Three groups of fructans are distinct. The first group corresponds to products whose fructose units are mostly linked by β (2,1) bonds. These are substantially linear fructans, such as inulin.

The second group also corresponds to linear fructose, but the fructose units are essentially linked by β (2,6) bonds. These products are levans.

The third group corresponds to mixed fructans, i.e. containing β (2,6) and β (2,1) sequences. These are substantially branched fructans, such as branched fructans (graminans).

The preferred fructan in the composition of the invention is inulin. Inulin may be obtained, for example, from chicory, dahlia or jerusalem artichoke, preferably from chicory.

In particular, polysaccharides, in particular inulin, have a degree of polymerization of from 2 to about 1000 and preferably from 2 to about 60, and a degree of substitution of less than 2, based on one fructose unit.

The inulin used in the invention is, for example, available under the name Beneo from the company Orafti^TMInulin and Sensus company under the name Frutafit^®A product representative of the sale.

b) Heteropolysaccharides and derivatives thereof

The polysaccharide which may be used according to the invention may be a gum, such as cassia gum, karaya gum, konjac gum, tragacanth gum, tara gum, acacia gum or acacia gum.

Ara-laGum arabic

Gum arabic is a highly branched acidic polysaccharide in the form of a mixture of potassium, magnesium and calcium salts. The monomer units of the free acid (arabinonic acid) are D-galactose, L-arabinose, L-rhamnose and D-glucuronic acid.

Galactomannans (guar, locust bean, fenugreek, tara gum) and derivatives (guar phosphate, hydroxypropyl guar, etc.)

Galactomannans are nonionic polyglycosides extracted from the endosperm of leguminous seeds, which constitute the storage carbohydrates therein.

Galactomannans are macromolecules consisting of a backbone of β (1,4) -linked D-galactopyranose units with side chains consisting of individual D-galactopyranose units linked to the backbone α (1,6) -. The differences among the galactomannans are, firstly, the proportion of alpha-D-galactopyranose units present in the polymer and, secondly, the significant differences in the distribution of the galactose units along the mannose chain.

The mannose/galactose (M/G) ratio is about 2 for guar gum, about 3 for tara gum, and about 4 for locust bean gum.

Guar gumGlue

Guar gum is characterized by a mannose/galactose ratio of about 2/1. Galactose groups are regularly distributed along the mannose chain.

The guar gums that can be used according to the present invention can be nonionic, cationic or anionic. According to the invention, chemically modified or unmodified non-ionic guar gums can be used.

Unmodified non-ionic Guar gums are for example the products sold by Unipektin under the names Vidogum GH, Vidogum G and Vidocrem and by Rhodia under the names Jaguar, by Danisco under the names Meypro Guar, by Cargill under the names Viscogum, and by Aqualon under the names Supercol Guar.

The hydrolysed non-ionic guar gum which can be used according to the invention is for example sold under the name Meyprodor by the company Danisco^®A product for sale.

According to the inventionThe modified nonionic guar used is preferably selected from C_1-6Hydroxyalkyl modification, among which mention may be made, for example, of hydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl.

Such non-ionic guar gums optionally modified with hydroxyalkyl groups are for example sold under the names Jaguar HP 60, Jaguar HP 105 and Jaguar HP 120 (hydroxypropyl guar) by the company Rhodia or N-Hance by the company Aqualon^®HP (hydroxypropyl guar) is sold.

The cationic galactomannan gum preferably has a cationic charge density of less than or equal to 1.5meq/g, more particularly between 0.1 and 1 meq/g. The charge density can be determined by the Kjeldahl method. It usually corresponds to a pH of around 3 to 9.

Generally, for the purposes of the present invention, the term "cationic galactomannan gum" refers to any galactomannan gum containing cationic groups and/or groups that can be ionized into cationic groups.

Preferred cationic groups are selected from those comprising primary, secondary, tertiary and/or quaternary amine groups.

The cationic galactomannan gum used will generally have a viscosity of between about 500 and 5X 10⁶And preferably between about 10³And 3X 10⁶Weight average molecular weight of (a) to (b).

Cationic galactomannan gums which may be used in accordance with the present invention are, for example, those comprising a tri (C)_1-4) Gums of alkylammonium cationic groups. Preferably, from 2% to 30% of the number of hydroxyl functions of these gums carry trialkylammonium cationic groups.

Among these trialkylammonium groups, mention may be made most particularly of the trimethylammonium and triethylammonium groups.

Even more preferably, these groups comprise 5 to 20 wt.% relative to the total weight of the modified galactomannan gum.

According to the invention, the cationic galactomannan gum is preferably a guar gum comprising hydroxypropyl trimethylammonium groups, i.e.: for example guar modified with 2, 3-epoxypropyltrimethylammonium chloride.

These galactomannan gums, in particular guar gums modified with cationic groups, are products known per se and are described, for example, in patents US 3589578 and US 4031307. Furthermore, such products are sold by, inter alia, Rhodia under the trade names Jaguar EXCEL, Jaguar C13S, Jaguar C15, Jaguar C17 and Jaguar CI 62 (Guar hydroxypropyltrimonium chloride), Degussa under the name Amilan Guar (Guar hydroxypropyltrimonium chloride), and Aqualon under the name N-Hance 3000 (Guar hydroxypropyltrimonium chloride).

Anionic guar gums which can be used according to the present invention are polymers comprising groups derived from carboxylic, sulfonic, sulfenic, phosphoric, phosphonic or pyruvic acids. The anionic group is preferably a carboxylic acid group. The anionic groups may also be in the form of acid salts, especially sodium, calcium, lithium or potassium salts.

The anionic guar that can be used according to the invention is preferably a carboxymethyl guar derivative (carboxymethyl guar or carboxymethyl hydroxypropyl guar).

Robinia pseudoacacia

The locust bean gum is derived from locust bean tree carob bean (Ceratonia siliqua) Is extracted from the seeds of (1).

Unmodified locust bean gum useful in the present invention is for example available from Cargill under the name viscogon^TMThe company Unipektin under the name Vidogum L and the company Danisco under the name Grinsted^®LBG is sold.

Chemically modified locust bean gums useful in the present invention can be represented, for example, by cationic locust beans sold by the company Toho under the name Catinal CLB (locust bean hydroxypropyltrimonium chloride).

Tara glue

Tara gum that can be used in the context of the present invention is sold, for example, by the company Unipektin under the name Vidogum SP.

Glucomannan (konjak glue)

Glucomannans are high molecular weight polysaccharides (500000 < M glucomannan < 2000000) consisting of D-mannose and D-glucose units, with approximately one branch per 50 or 60 units. It is present in wood, but is also the main component of konjac gum. Amorphophallus konjac (Amorphophalus konjac) is a plant of the family Araceae.

Products which can be used according to the invention are for example under the name Propol by the company Shimizu^®And Rheolex^®And (5) selling.

Other polysaccharides

Among the other polysaccharides that can be used according to the invention, mention may also be made of chitin (poly-N-acetyl-D-glucosamine, β (1,4) -2-acetamido-2-deoxy-D-glucose), chitosan and its derivatives (chitosan- β -glycerophosphate, carboxymethyl chitin, etc.), such as those sold by the company France-chitin; glycosaminoglycans (GAGs) such as hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, and preferably hyaluronic acid; xylan (or arabinoxylan) and derivatives.

Arabinoxylans are polymers of xylose and arabinose, both classified under the names pentosans. Xylans consist of a backbone of β (1,4) linked D-xylose units, on which three substituents are found (Rouau & Thibault, 1987): acid units, alpha-L-arabinofuranose units, side chains which may contain arabinose, xylose, galactose and glucuronic acid.

According to this variant, the polysaccharide is preferably hyaluronic acid or a salt thereof.

The at least one hydrophilic gelling agent may be present in an amount ranging, for example, from 0.001 to 10 wt.%, preferably from 0.01 to 5 wt.%, and more preferably from 0.05 to 3 wt.%, relative to the total weight of the second composition.

Active agent

According to one embodiment of the invention, the first composition may comprise at least one active agent.

According to one embodiment of the invention, the second composition may comprise at least one active agent.

When the first composition comprises at least one active agent, it may be incorporated into the first composition, in particular by means of an alternating electric field. The active agent(s) may be incorporated in particular in the powder state.

Among all the active agents which can be used in the present invention, mention may in particular be made of: alpha-or beta-hydroxy acids such as lactic acid, glycolic acid, citric acid, 5-octanoylsalicylic acid, alpha-hydroxydecanoic acid, alpha-hydroxylauric acid, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, alpha-hydroxybutyric acid, alpha-hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid and salicylic acid.

Anti-acne agents such as salicylic acid or benzoyl peroxide, octopirox, dextro-and levorotatory sulfur-containing amino acids, their salts and their N-acetyl derivatives such as N-acetylcysteine, or agents seeking to prevent skin aging and/or improve its condition, for example the above-mentioned alpha-and beta-hydroxy acids, retinoids such as retinoic acid, retinol and its esters, for example retinol propionate and retinol acetate or retinol palmitate, niacinamide, allantoin, aloe vera extract, azelaic acid, bisabolol, phytic acid, collagen, or agents stimulating collagen formation, vitamins such as vitamin C or its derivatives such as ascorbyl glucoside, vitamin E or its derivatives, vitamin A or its derivatives, vitamin F or its derivatives, dextro-and levorotatory sulfur-containing amino acids and their derivatives as described above, vitamin F and its derivatives, vitamin C and its derivatives, Elastin, N-acetyl D-glucosamine, luteolin, or antioxidants such as green tea or its active ingredient, glycerol, laponite (laponite), caffeine, essential aromatic oils, colorants, free radical scavengers, moisturizers, depigmenting agents, agents for improving skin color such as artificial tanning agents of the dihydroxyacetone or tyrosine ester type, lipid regulating agents, emollients, anti-wrinkle agents, keratolytic agents, freshening agents, deodorants, anesthetics, nourishing agents, and mixtures thereof. Bleaching agents such as kojic acid, ascorbic acid phosphate, ascorbic acid glucoside, ascorbic acid, and mixtures thereof may also be used.

In the case of a mask, it is also possible to use active agents for improving the skin condition, such as moisturizers or agents for improving the natural lipid barrier, such as ceramides, cholesterol sulfates and/or fatty acids, and mixtures thereof. Enzymes active on the skin, such as proteases, lipases, cerebrosidases and/or melanoses, and mixtures thereof, may also be used.

As further examples of active agents that may be suitable for use in the practice of the present invention, there are the following agents: a drug, a peptide, a protein, a detectable label, a contrast agent, an analgesic, an anesthetic, an antibacterial agent, an anti-yeast agent, an antifungal agent, an antiviral agent, an anti-dermatitis agent, an antipruritic agent, an antiemetic agent, a vasoprotective agent, an anti-motion agent, an anti-irritant agent, an anti-inflammatory agent, an immunomodulator, an anti-overactive agent, a dry skin treatment agent, an antiperspirant, an anti-psoriasis agent, an anti-dandruff agent, an anti-aging agent, an anti-asthma and bronchodilator, a sunscreen, an antihistamine, a healing agent, a corticosteroid, a tanning agent, and mixtures thereof.

The level of the at least one active agent in the first composition and/or the second composition may be adjusted depending on the intended purpose of the kit.

Alkali metal hyaluronic acid compound

Hyaluronic acid-based compounds may also be used as active agents according to the invention. The hyaluronic acid-based compound is preferably an alkali metal hyaluronic acid-based compound.

The term "alkali metal hyaluronate" refers in particular to an alkali metal salt of hyaluronic acid (hyaluronate) or a derivative thereof. The alkali metal hyaluronic acid-based compound is water-soluble.

In the context of the present invention, the term "hyaluronic acid or derivative thereof" specifically covers the basic unit of hyaluronic acid of the formula:

it is the smallest fraction of hyaluronic acid containing the disaccharide dimer, i.e. D-glucuronic acid and N-acetylglucosamine.

In the context of the present invention, the term "hyaluronic acid or derivative thereof" also includes linear polymers comprising the above-mentioned polymeric units, linked together in the chain by alternating β (1,4) and β (1,3) glycosidic bonds, having a molecular weight (Mw) which may range between 380 and 13000000 daltons. The molecular weight depends to a large extent on the source of the hyaluronic acid obtained and/or the method of preparation.

In the natural state, hyaluronic acid is present in the gel surrounding the cells, in the basic substance of the connective tissues of vertebrate organs, such as the dermis and epithelial tissues, and in particular in the epidermis, in the synovial fluid of the joints, in the vitreous humor, in the human umbilical cord and in the processes of cockscomb (crista galli apophysis).

Thus, the term "hyaluronic acid or derivative thereof" includes all fractions or subunits of hyaluronic acid having a molecular weight, in particular within the above molecular weight ranges.

By way of illustration of the various hyaluronic acid fractions, reference may be made to the document "Hyaluronan fragments: an information-rich system", R.Stern et al, European Journal of Cell Biology 58 (2006) 699-715, which reviews the biological activities of hyaluronic acid as listed in terms of its molecular weight.

According to a preferred embodiment of the invention, the hyaluronic acid fraction suitable for the uses contemplated by the invention has a molecular weight comprised between 50000 and 5000000, in particular between 100000 and 5000000, especially between 400000 and 5000000 Da. In this case, the term used is high molecular weight hyaluronic acid.

Alternatively, hyaluronic acid fractions which may also be suitable for the uses contemplated by the present invention have a molecular weight between 50000 and 400000 Da. In this case, the term used is medium molecular weight hyaluronic acid.

Still alternatively, the hyaluronic acid fraction suitable for use contemplated by the present invention has a molecular weight of less than 50000 Da. In this case, the term used is low molecular weight hyaluronic acid.

Finally, the term "hyaluronic acid or derivatives thereof" also includes hyaluronic acid esters, in particular those in which all or part of the carboxyl groups of the acid functional groups are esterified with oxyethylenated alkyl or alcohol groups containing from 1 to 20 carbon atoms, in particular hyaluronic acid esters having a degree of substitution ranging from 0.5 to 50% at the level of D-glucuronic acid of the hyaluronic acid.

More specifically, hyaluronic acid or hyaluronate may be reacted with an alkylene oxide, such as ethylene oxide or propylene oxide, to form polyglycol hyaluronate. The polyglycol segment is bound to the hyaluronic acid via the carboxyl group(s). Typically, hyaluronic acid or hyaluronate is reacted with propylene oxide to form polypropylene glycol hyaluronate and ethylene oxide to form polyethylene glycol hyaluronate.

Furthermore, methyl, ethyl, n-propyl, n-pentyl, benzyl and dodecyl esters of hyaluronic acid may be mentioned. Such esters have been described in particular in "semi synthetic resinous materials from hydrophilic esterification" by D.Campocia et al, Biomaterials 19 (1998) 2101-2127 ".

The above molecular weights are also effective for hyaluronic acid esters.

Water-soluble carbonates or bicarbonates

The kit of the present invention may comprise a water-soluble carbonate or bicarbonate salt that generates carbon dioxide upon mixing with the acidic reagent in the kit, thereby enhancing blood circulation through the skin. For convenience, the term (bi) carbonate in this context means carbonate and/or bicarbonate.

Useful carbonates include carbonates of metals from group I of the periodic table, preferably sodium carbonate, potassium carbonate, or mixtures thereof.

Useful bicarbonates include bicarbonates of metals from group I and/or group II of the periodic table, preferably sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, calcium bicarbonate, barium bicarbonate, or mixtures thereof.

According to one embodiment of the kit of the invention, the (bi) carbonate salt may be added to the first composition or the second composition, or both. If a water-soluble (bi) carbonate salt is added to the second composition, it is dissolved according to any conventional method.

According to one embodiment, the at least one carbonate or bicarbonate salt is added in a content ranging from 0.01% to 30% by weight, in particular from 0.1% to 20% by weight, such as from 0.2% to 10% by weight, relative to the total weight of the first composition, despite the addition of a (bi) carbonate salt to the first and/or second composition.

Method for bonding carbonate (bicarbonate) to a substrate

In one embodiment, the (bi) carbonate salt is added to the first composition and combined with the water-insoluble substrate. The method of combining the carbonate or bicarbonate with the water-insoluble substrate is not particularly limited as long as the carbonate or bicarbonate can be uniformly distributed in the substrate in an amount sufficient to soften the substrate to the desired degree.

According to one embodiment, the carbonate or bicarbonate is prepared as an aqueous solution. The carbonate or bicarbonate salt is then loaded onto a substrate, such as a mask towel.

According to another embodiment, the carbonate or bicarbonate is prepared as a suspension or paste, e.g., a water-soluble carbonate or bicarbonate is suspended in or mixed with a liquid medium other than water to form a suspension or paste thereof. The suspension or paste is then applied to the substrate, for example by coating, spraying, or the like, so that the carbonate or bicarbonate is uniformly distributed in the substrate in an amount sufficient to form a gel with the alginate on the substrate.

For the case where the carbonate or bicarbonate is applied using a wet form, i.e., an aqueous solution, suspension or paste, the wet substrate loaded with aqueous salt is then dried or subjected to any other method to remove the liquid medium. The method of drying the tissue or removing the liquid medium is not particularly limited. For industrial applications, wet substrates are dried in an economically efficient manner.

According to yet another embodiment, the carbonate or bicarbonate in solid form is comminuted into a powder or granules, for example by milling, grinding or the like. The powder or granules are then applied uniformly to the substrate. The diameter of the powder or particles is not particularly limited as long as the carbonate or bicarbonate can be uniformly distributed in the substrate in an amount sufficient to soften the substrate.

According to the present invention, the water insoluble substrate or fabric may comprise carbonate or bicarbonate in an amount ranging from 0.01 to 30 wt. -%, in particular from 0.1 to 20 wt. -%, like from 0.2 to 10 wt. -%, relative to the total weight of the water insoluble substrate or fabric.

According to the present invention, since the second composition comprises an aqueous phase, at most one of the acidic agent and the (bi) carbonate is added to the second composition to avoid reaction between them before use.

In this embodiment, the acidic agent and the (bi) carbonate are both used as solids in a first composition comprising a water-insoluble substrate, to which the acidic agent can be added in the same manner as the method of binding the bicarbonate to the substrate. It is to be noted, however, that it should be avoided that both the acidic agent and the (bi) carbonate are added as an aqueous solution, suspension or paste. In other words, at least one of the acidic agent and the (bi) carbonate is added in dry form, i.e. as a powder or granules, e.g. by milling, grinding, etc. Further, if both the acidic agent and the (bi) carbonate are added to the first composition in dry form, the order of addition of the acidic agent and the (bi) carbonate is not particularly limited. In contrast, if either of the acidic agent and the (bi) carbonate salt are added in wet form as an aqueous solution, suspension or paste, while the other is added in dry form, the wet form is first added to the substrate and after drying or removal of the liquid medium, the dry form is then added.

Adjuvant

In a known manner, the second composition of the invention may also contain adjuvants commonly found in cosmetics and/or dermatology, such as preservatives, antioxidants, pH regulators (acidic or basic), fragrances, fillers, bactericides, odor absorbers, colorants (pigments and dyes), emulsifiers and lipid vesicles.

Needless to say, the person skilled in the art will take care to select this or these optional additional compound(s) and/or the amount thereof such that the benefit of the second composition according to the invention is not, or is not substantially, adversely affected by the intended addition.

Galenic preparation

Form(s) of

The second composition according to the invention can be in various forms, in particular in the form of an aqueous solution, dispersion or emulsion, such as in particular a water/oil or oil/water emulsion or a multiple emulsion.

The emulsion may have an oily or aqueous continuous phase. Such emulsions may be, for example, inverse (W/O) or direct (O/W) emulsions, or multiple emulsions (W/O/W or O/W/O).

In the case of emulsions, direct (O/W) emulsions are preferred.

In particular, the second composition according to the invention may be in the form of an oil-in-water (O/W) emulsion, a water-in-oil (W/O) emulsion or a multiple emulsion, preferably an oil-in-water (O/W) emulsion.

The second composition of the present invention is preferably an aqueous solution.

According to a preferred embodiment of the invention, the kit is presented as a mask comprising:

1) a nonwoven fabric (or tissue) comprising, relative to the total weight of the nonwoven fabric:

from 10% to 80% by weight, in particular from 10% to 40% by weight, of calcium alginate fibers, and

0.01 to 20 wt.%, in particular 0.1 to 15 wt.%, of at least one acidic agent;

2) a composition comprising, relative to the total weight of the composition, from 10% to 99% by weight, preferably from 50% to 99% by weight, of at least one aqueous phase, from 0.1% to 0.5% by weight, preferably from 0.1% to 0.3% by weight, of sodium alginate, and from 0.1% to 0.5% by weight, preferably from 0.2% to 0.4% by weight, of sodium citrate; and

3) 0.01 to 30 wt. -%, in particular 0.1 to 20 wt. -%, relative to the total weight of the nonwoven (tissue), of at least one carbonate or bicarbonate, added to the first or second composition, or both;

wherein the weight ratio of the nonwoven fabric to the composition ranges from 1:3 to 1:20, preferably from 1:8 to 1: 15.

Method and use

The first and second/fourth compositions according to the invention may generally be prepared according to the common general knowledge of a person skilled in the art. Nevertheless, it will be understood that the person skilled in the art may select the preparation method on the basis of his general knowledge, taking into account the nature of the ingredients used, for example their solubility in the carrier, and taking into account the applications envisaged for the composition or kit.

According to one embodiment, the kit according to the invention can be used for caring for keratin materials, in particular the face. This use may be represented by a method for caring for keratin materials, in particular the face, comprising the following steps: the first and second compositions of the kit are mixed in a predetermined weight ratio and the mixture thus obtained is then applied as a mask on the keratin materials.

According to one embodiment, the kit according to the invention may be used for treating skin wounds, for preventing post-operative adhesion formation or for filling or repairing osteochondral defects, or the like. This use may be manifested as a method of treating a skin wound, preventing post-operative adhesion formation, or filling or repairing an osteochondral defect, comprising the steps of: the first composition and the second composition of the kit are formulated in a predetermined weight ratio and then applied to a place where the mixture thus obtained is required as a mask or a pack.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective measurements. The following examples are intended to illustrate the invention without thereby limiting its scope.

Examples

The amounts/concentrations of the ingredients in the compositions/formulations described below are expressed in weight% relative to the total weight of each composition/formulation.

I. Preparation of

Inventive formulations a and B, and comparative formulations (comparative) a-E were prepared as the second composition.

TABLE 1

Evaluation II

Evaluation of bubble volume

After mixing the juice with ascorbic acid, bubbles were clearly observed. The score is defined as when it is mixed with juice, is If no bubble is generated, the following is shown.

5 generating a large amount of foam

3 generating foam

1: no foam generation

Long-term carbon dioxide evaluation

First, the samples were freshly mixed and then massaged thoroughly for 1 minute, then removed from the pouch and spread. Placing the facial mask On the plate, disappearance of bubbles was observed. They were scored according to the following definitions.

5 air bubbles exist and can be seen for more than 10 minutes

4, air bubbles exist and can be seen for 10-7 minutes

3 air bubbles exist and can be seen for 7-3 minutes

2 bubbles present and visible for less than 3 minutes

1: no bubble

Evaluation of gelation degree

After freshly mixing and spreading the mask, after leaving for 10 minutes, the degree of gelation was evaluated according to the following definition

5 thick gel

4: slightly thickened gel

Fluid gel

2 water containing dew (position)

1: no matterGround transition

Evaluation of

See the accompanying Excel file.

Nonwoven reference 20% calcium alginate: 20% calcium alginate fibers + 80% tencel. V55 common use for sheet-like facial mask A regular non-woven fabric. Rayon 100%, 55 mg. Gauze: it is a 3-layer fabric lyocell/cotton gauze/lyocell, 60 smg

Conclusion III

Inventive examples a and B are superior to the comparative examples at all evaluation points.

The foregoing description illustrates and describes the present disclosure. Further, the disclosure shows and describes only the preferred embodiments of the disclosure, but, as mentioned above, it is to be understood that variations or modifications commensurate with the above teachings and/or skill or knowledge of the relevant art can be made within the scope of the concepts as expressed herein. The foregoing further is intended to explain the best mode known of practicing the disclosure and to enable others skilled in the art to utilize the disclosure in such or other embodiments and with various modifications required by the particular applications or uses disclosed herein. Accordingly, the description is not intended to limit the disclosure to the form disclosed herein. It is also intended that the appended claims be construed to include alternative embodiments.

All publications, patents, and patent applications cited in this specification are herein incorporated by reference, and for any and all purposes, as if each individual publication, patent, or patent application were specifically and individually indicated to be incorporated by reference. In the event of inconsistencies, the present disclosure controls.

Claims (29)

1. A kit, comprising:

1) a first composition comprising:

at least one water-insoluble polyvalent metal salt; and

2) a second composition comprising at least one aqueous phase, and

a) optionally, at least one water-soluble polyvalent metal ion chelating agent, and

b) at least one water-soluble gelling agent that can gel with the polyvalent metal ion; and

3) at least one water soluble carbonate or bicarbonate salt added to the first composition or the second composition, or both;

wherein the first and second compositions are placed apart from each other.

2. The kit of claim 1, wherein the gelling agent is specifically selected so that the ability to bind to polyvalent metal ions is less than the ability to bind to a chelating agent.

3. The kit of any one of the preceding claims, wherein the water-insoluble multivalent metal salt is selected from water-insoluble salts of calcium, strontium, zinc, copper, manganese, or mixtures thereof.

4. Kit according to any one of the preceding claims, wherein said at least one water-insoluble polyvalent metal salt is a water-insoluble calcium salt selected from calcium alginate, calcium sulphate and calcium carbonate or mixtures thereof.

5. The kit according to any one of the preceding claims, wherein the carbonate or bicarbonate comprises a carbonate salt of a metal from group I of the periodic table, preferably sodium carbonate, potassium carbonate, and a bicarbonate salt of a metal from group I and/or group II of the periodic table, preferably sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, calcium bicarbonate, barium bicarbonate, or mixtures thereof.

6. Kit according to any one of the preceding claims, wherein the kit comprises at least one carbonate or bicarbonate in a content ranging from 0.01% to 30% by weight, in particular from 0.1% to 20% by weight, such as from 0.2% to 10% by weight, relative to the total weight of the first composition.

7. Kit according to any one of the preceding claims, wherein the water-insoluble multivalent metal salt is in the form of a fiber, which together with one or more other fibers forms a water-insoluble substrate, to which substrate carbonate or bicarbonate is loaded, wherein the one or more other fibers are selected from natural fibers such as cotton, pulp, bamboo and cellulose fibers, semi-natural fibers such as viscose rayon fibers, synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers, or mixtures thereof.

8. The kit according to claim 7, wherein the water insoluble substrate comprises water insoluble polyvalent metal salt fibers in an amount ranging from 10 to 80 wt. -%, in particular from 10 to 40 wt. -%, and at least one additional fiber in an amount ranging from 10 to 80 wt. -%, in particular from 50 to 80 wt. -%, relative to the total weight of the water insoluble substrate.

9. The kit of any one of the preceding claims, wherein the at least one water-soluble polyvalent metal ion chelator comprises an aminocarboxylic acid, a hydroxycarboxylic acid, a hydroxyaminocarboxylic acid, a polyphosphonic acid, another phosphorus-containing organic acid, or a mixture thereof.

10. The kit according to any one of the preceding claims, wherein the at least one water soluble chelating agent is selected from sodium citrate, disodium EDTA, tetrasodium GLDA, trisodium EDDS, sodium phytate, potassium phytate, and mixtures thereof.

11. The kit according to any one of the preceding claims, wherein the at least one water-soluble multivalent metal ion chelator is present in the second composition from 0.1 wt.% to 1 wt.%, preferably from 0.2 wt.% to 0.4 wt.%, relative to the total weight of the second composition.

12. The kit of any one of the preceding claims, wherein the at least one gelling agent comprises gelatin, pectin, gellan gum, carrageenan, agar, alkali metal salts of alginic acid, and mixtures thereof.

13. Kit according to any one of the preceding claims, wherein the gelling agent is selected from alkali metal alginates, alkali metal salts of alginic acid derivatives or mixtures thereof, preferably sodium alginate, potassium alginate, lithium alginate, sodium polyethylene glycol alginate, potassium polyethylene glycol alginate, lithium polyethylene glycol alginate, or mixtures thereof.

14. The kit of claim 13, wherein the alkali metal alginic compound is selected from the group consisting of sodium alginate and potassium alginate, more preferably sodium alginate.

15. Kit according to any one of the preceding claims, in which the at least one water-soluble gelling agent is present in the second composition at from 0.1% to 0.5% by weight, preferably from 0.1% to 0.3% by weight, relative to the total weight of the second composition.

16. Kit according to any one of the preceding claims, in which the at least one aqueous phase is present in the second composition at from 10% to 99% by weight, preferably from 50% to 99% by weight, relative to the total weight of the second composition.

17. The kit of any one of the preceding claims, wherein the kit further comprises an acidic reagent in the first composition and/or in the second composition.

18. The kit of claim 17, wherein the acidic reagent is at least one organic acid selected from the group consisting of: formic acid, acetic acid, propionic acid, butyric acid, valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, terephthalic acid, glutamic acid, aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropine acid, ascorbic acid, and gluconic acid; or inorganic acids such as phosphoric acid; an acidic derivative thereof or a mixture thereof.

19. The kit of claim 17, wherein the acidic agent is added to the first composition and is selected from oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, terephthalic acid, glutamic acid, aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid, 3-o-ethyl ascorbic acid, ascorbyl glucoside, or a mixture thereof, preferably ascorbic acid.

20. Kit according to claim 19, wherein the acidic agent is preferably used in an amount of 0.01-20%, preferably 0.1-15% or preferably 0.2-10% relative to the weight of the first composition.

21. The kit according to any one of the preceding claims, wherein the weight ratio of the first composition to the second composition ranges from 1:3 to 1:20, preferably from 1:8 to 1: 15.

22. The kit according to any one of the preceding claims, wherein the second composition comprises at least one hydrophilic gelling agent and/or at least one active agent.

23. The kit according to any one of the preceding claims, wherein the at least one carbonate or bicarbonate salt is added to the second composition.

24. The kit of any one of the preceding claims, wherein the at least one carbonate or bicarbonate salt is added to both the first and second compositions.

25. The kit according to any one of the preceding claims, presented as a mask, comprising:

1) a nonwoven fabric (or tissue) comprising, relative to the total weight of the nonwoven fabric:

from 10% to 80% by weight, in particular from 10% to 40% by weight, of calcium alginate fibers, and

0.01 to 20 wt.%, in particular 0.1 to 15 wt.%, of at least one acidic agent; and

2) composition comprising, relative to the total weight of the composition, from 10% to 99% by weight, preferably from 50% to 99% by weight, of at least one aqueous phase, from 0.1% to 0.5% by weight, preferably from 0.1% to 0.3% by weight, of sodium alginate, and from 0.1% to 0.5% by weight, preferably from 0.2% to 0.4% by weight, of sodium citrate, and

3) 0.01 to 30 wt.%, in particular 0.1 to 20 wt.%, relative to the total weight of the nonwoven fabric, of at least one carbonate or bicarbonate, which is added to the composition,

wherein the weight ratio of the nonwoven fabric to the composition ranges from 1:3 to 1:20, preferably from 1:8 to 1: 15.

26. The kit according to any one of the preceding claims, wherein the amounts of chelating agent and gelling agent are selected such that the molar ratio of the fraction released from the chelating agent that can be chelated with multivalent cations to the fraction released from the gelling agent that can be gelled with multivalent cations ranges from about 10:1 to about 1:1, preferably from about 5:1 to about 2: 1.

27. Use of a kit according to any one of the preceding claims for caring for keratin materials, in particular the skin, for treating skin wounds, for preventing post-operative adhesion formation or for filling or repairing osteochondral defects.

28. Method for caring for keratin materials, in particular the skin, for treating skin wounds, for preventing postoperative adhesion formation or for filling or repairing osteochondral defects, comprising the steps of: compounding the first and second compositions of the kit according to any one of the preceding claims in a weight ratio of the first to the second composition of from 1:3 to 1:20, preferably from 1:8 to 1:15, and then applying to the site where the mixture thus obtained is desired.

29. Use of a second composition as defined in any of the preceding claims as a juice or partial juice of a mask product, wherein the mask product comprises a tissue separate from the second composition, the tissue comprising the at least one water-insoluble multivalent metal salt.