CN113181569A - Closed-loop transcranial brain stimulation system and method - Google Patents
Closed-loop transcranial brain stimulation system and method Download PDFInfo
- Publication number
- CN113181569A CN113181569A CN202110457551.0A CN202110457551A CN113181569A CN 113181569 A CN113181569 A CN 113181569A CN 202110457551 A CN202110457551 A CN 202110457551A CN 113181569 A CN113181569 A CN 113181569A
- Authority
- CN
- China
- Prior art keywords
- signal
- brain
- module
- transcranial
- stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Electrotherapy Devices (AREA)
Abstract
The application provides a closed-loop transcranial brain stimulation system and a closed-loop transcranial brain stimulation method, which comprise a transcranial ultrasonic signal generating module, a transcranial ultrasonic stimulation module, a brain and muscle electrical signal acquisition and processing module and an electrode module; the electrode module is used for collecting brain muscle signals of the experimental object; the brain electromyographic signal acquisition processing module is configured for acquiring signals of the electrode module, and sending detection signals to the transcranial ultrasonic signal generating module after signal processing; the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module; the transcranial ultrasound stimulation module is configured to transmit ultrasound stimulation to the subject in accordance with the stimulation signal. The beneficial effect of this application is: the transcranial ultrasonic signal generation module adjusts signal parameters of the transcranial ultrasonic stimulation module to the experimental object next time according to the brain muscle signals acquired by the electrode module and a configuration strategy according to the system expected value, so that closed-loop control of transcranial brain stimulation is achieved.
Description
Technical Field
The disclosure relates to the technical field of transcranial ultrasonic stimulation, in particular to a closed-loop transcranial stimulation system and method.
Background
In recent years, with the rapid development of electronic technology, the development of electrical stimulator products has been very rapid. These electrical stimulators have undergone early discrete device fabrication, and to date, implantable, miniaturized designs have made great progress, both in size and function. The stimulator is used for clinical heart or brain, such as special stimulator for cardiac pacemaker and cerebral pacemaker, and general stimulator for scientific research. Although some electrical stimulators have already entered the clinical stage of use and achieved good therapeutic results, there are some problems in particular fields of application: the current general electric stimulator can not automatically generate stimulation according to the change of physiological signals, and mainly sends out stimulation signals at artificially specified time through a preset stimulation mode. However, in some applications, such as the study of learning and memory mechanism of brain, electrical stimulation is required to be performed at a specific phase of the brain electrical rhythm to produce different effects, such as long-term enhancement or long-term inhibition. That is, the stimulation methods commonly used today cannot form a complete closed loop and cannot adjust control parameters autonomously.
In recent years, brain stimulation techniques such as deep brain stimulation, optogenetic stimulation, transcranial magnetic stimulation, etc. have evolved rapidly (Kraus et al, 2016; milouch vicker et al, 2018; tremolo et al, 2018). Compared with open-loop brain stimulation, closed-loop brain stimulation can perform brain neuromodulation in real time through brain states, and achieve targeted on-demand stimulation (Muller et al, 2012; Cagnan et al, 2017; weeks et al, 2019). Studies of memory and learning mechanisms have shown that stimulation of brain tissue at specific stages of neural oscillation produces different effects, such as long-term potentiation or long-term inhibition (Hyman et al, 2003; Ezzyat et al, 2018). Transcranial Ultrasound Stimulation (TUS) is a physical neuromodulation technique that is non-invasive, has a large penetration depth, and has high spatial resolution (Bystritsky et al, 2011; Fomenko et al, 2018). TUS has attracted considerable attention and has been used in a number of animal and human experiments (Bystritsky and Korb, 2015; cattle et al, 2018; et al, 2019). However, all TUS methods provide brain stimulation in an open-loop mode that emits stimulation signals at artificially defined times and does not automatically generate stimulation in response to changes in physiological signals of the brain tissue. This open-loop method does not have the property of real-time processing and belongs to the class of off-line analysis. Therefore, a method for real-time acquisition and processing is needed, closed-loop control is a direction to be developed for the application of the stimulation, ultrasonic stimulation can be applied at specific time according to the electrical activity state of the brain, and the closed-loop transcranial ultrasonic stimulation method has important significance for disclosing a neural information processing mechanism and optimizing treatment of the neural diseases.
Disclosure of Invention
It is an object of the present application to address the above problems and to provide a closed loop transcranial stimulation system and method.
In a first aspect, the present application provides a closed-loop transcranial brain stimulation system, which includes a transcranial ultrasonic signal generation module, a transcranial ultrasonic stimulation module, a brain-muscle electrical signal acquisition processing module and an electrode module; the electrode module is electrically connected to the experimental subject and used for collecting brain muscle signals of the experimental subject; the brain electromyographic signal acquisition processing module is electrically connected with the electrode module, the transcranial ultrasonic signal generation module is electrically connected with the brain electromyographic signal acquisition processing module, and the transcranial ultrasonic stimulation module is electrically connected with the transcranial ultrasonic signal generation module; the brain and muscle electrical signal acquisition and processing module is configured for acquiring signals of the electrode module, and sending detection signals to the transcranial ultrasonic signal generation module after signal processing; the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module; the transcranial ultrasound stimulation module is configured to transmit ultrasound stimulation to a subject according to a stimulation signal.
According to the technical scheme provided by the embodiment of the application, the brain and muscle electric signal acquisition and processing module comprises a front-end amplifier, a microelectrode AC amplifier, a nerve signal processor and a first computing unit; the front-end amplifier is electrically connected with the electrode module and is used for amplifying the received brain muscle signals sent by the electrode module and sending the amplified signals to the microelectrode AC amplifier; the microelectrode AC amplifier is configured to amplify and filter the brain muscle signals and send the processed signals to the neural signal processor; the neural signal processor is configured to convert the brain muscle signals into corresponding digital signals and send the converted digital signals to the first computing unit; the first computing unit is configured to perform signal processing on the digital signal and send the processed signal to the transcranial ultrasound signal generating module.
According to the technical scheme provided by the embodiment of the application, the transcranial ultrasonic signal generation module comprises a second calculation unit and a radio frequency amplifier; the second computing unit receives the signal sent by the first computing unit and generates a control waveform signal according to a configuration strategy; the radio frequency amplifier amplifies the control waveform signal and sends the processed control signal to the transcranial ultrasonic stimulation module.
According to the technical scheme provided by the embodiment of the application, the transcranial ultrasonic stimulation module comprises an ultrasonic transducer and a collimator; the ultrasonic transducer is configured to enable the control signal sent by the radio frequency amplifier to be an ultrasonic output; the collimator is fixedly connected to the output end of the ultrasonic transducer and is configured to limit the ultrasonic output within a set range to be emitted to the experimental object.
According to the technical scheme provided by the embodiment of the application, the electrode module comprises an electroencephalogram electrode and an electromyogram electrode, the electroencephalogram electrode is configured to collect an electroencephalogram signal of an experimental object, and the electromyogram electrode is configured to collect an electromyogram signal of the experimental object; the electroencephalogram electrodes comprise three paths, wherein one path of electrode is inserted into the skull of the experimental object, and the other two paths of electrodes are inserted into the nasal bone of the experimental object to serve as reference electrodes; the myoelectric electrode comprises three paths, wherein one path of electrode is inserted under the skin in the middle of the tail of the experimental object, and the other two paths of electrode are respectively inserted on the two rear claws of the experimental object to be used as reference electrodes.
According to the technical scheme provided by the embodiment of the application, the first computing unit and the second computing unit are internally provided with a PCI-5122 digital signal acquisition card and a PCI-5412 waveform generator.
In a second aspect, the present application provides a closed-loop transcranial brain stimulation method comprising the steps of:
the electrode module collects original brain muscle signals of an experimental object and sends the signals to the brain muscle electrical signal collecting and processing module;
the brain-muscle electrical signal acquisition processing module carries out primary processing on the received original brain-muscle signals to obtain first brain-muscle signals, and the first brain-muscle signals are sent to the transcranial ultrasonic signal generating module;
the transcranial ultrasonic signal generation module carries out data processing on the received first brain muscle signal, forms a control signal according to a configuration strategy and sends the control signal to the transcranial ultrasonic stimulation module;
the transcranial ultrasonic stimulation module enables ultrasonic stimulation to a preset area of the experimental object according to the received control signal.
According to the technical scheme provided by the embodiment of the application, the electrode module collects the original brain muscle signals of the experimental subject, and the electrode module specifically comprises: the brain electric electrode is connected to a preset brain part of the test object, the myoelectric electrode is connected to a preset body part of the test object, the brain electric electrode acquires brain electric signals of the test object, and the myoelectric electrode acquires myoelectric signals of the test object.
According to the technical scheme provided by the embodiment of the application, the brain-muscle-electric-signal acquisition and processing module performs primary processing on the received original brain-muscle signal to obtain a first brain-muscle signal, and the method specifically comprises the following steps:
the original brain muscle signal is amplified through a front-end amplifier;
carrying out differential amplifier and filtering by a microelectrode AC amplifier;
converting the analog signal into a digital signal by a neural signal processor;
and performing Hilbert transform after filtering by a first computing unit, and obtaining an envelope to obtain an electroencephalogram peak value and an electromyogram average value to form the first brain muscle signal.
According to the technical scheme provided by the embodiment of the application, the transcranial ultrasonic signal generation module carries out data processing on the received first brain muscle signal and forms a control signal according to a configuration strategy, and the method specifically comprises the following steps:
comparing the first brain muscle signal with a set expected value to obtain an absolute error and a relative error;
and inputting the absolute error and the relative error into a control algorithm to obtain the control signal, wherein the control signal comprises a control signal for the amplitude and the duration of the ultrasonic wave.
The invention has the beneficial effects that: the application provides a closed-loop transcranial brain stimulation system and a closed-loop transcranial brain stimulation method, wherein an electrode module is used for detecting brain muscle signals of an experimental object, a brain muscle signal acquisition and processing module acquires the brain muscle signals and then sends the brain muscle signals to a transcranial ultrasonic signal generating module through primary processing, the transcranial ultrasonic signal generating module adjusts signal parameters of the transcranial ultrasonic stimulation module to the experimental object next time through a configuration strategy according to the brain muscle signals and a system expected value, so that the transcranial ultrasonic stimulation module transmits ultrasonic waves to the experimental object according to the adjusted parameters sent by the transcranial ultrasonic signal generating module to generate brain muscle signals, closed-loop control of transcranial brain stimulation is achieved, and closed-loop circulation control is performed in such a way until a set brain muscle value is achieved. The invention automatically adjusts the ultrasonic stimulation parameters, simply and quickly obtains the preset result, has the advantages of closed-loop feedback control, stable signal acquisition, high signal processing speed, simple operation and the like, and can effectively adapt to the multi-sample transcranial ultrasonic stimulation experiment.
Drawings
FIG. 1 is a schematic block diagram of a first embodiment of the present application;
FIG. 2 is a flow chart of a second embodiment of the present application;
fig. 3 is a detailed flowchart of step S2 in fig. 2.
Detailed Description
In order that those skilled in the art will better understand the technical solutions of the present invention, the following detailed description of the present invention is provided in conjunction with the accompanying drawings, and the description of the present section is only exemplary and explanatory, and should not be construed as limiting the scope of the present invention in any way.
Fig. 1 is a schematic diagram of a first embodiment of the present application, which includes a transcranial ultrasound signal generating module, a transcranial ultrasound stimulation module, a brain and muscle electrical signal collecting and processing module, and an electrode module; the electrode module is electrically connected to the experimental subject and used for collecting brain muscle signals of the experimental subject; the brain electromyographic signal acquisition processing module is electrically connected with the electrode module, the transcranial ultrasonic signal generation module is electrically connected with the brain electromyographic signal acquisition processing module, and the transcranial ultrasonic stimulation module is electrically connected with the transcranial ultrasonic signal generation module; the brain and muscle electrical signal acquisition and processing module is configured for acquiring signals of the electrode module, and sending detection signals to the transcranial ultrasonic signal generation module after signal processing; the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module; the transcranial ultrasound stimulation module is configured to transmit ultrasound stimulation to a subject according to a stimulation signal.
In the embodiment, an experimental subject is set as a white mouse which is commonly used in a laboratory test, the electrode module comprises an electroencephalogram electrode and a myoelectricity electrode, the electroencephalogram electrode is configured to collect electroencephalogram signals of the experimental subject, and the myoelectricity electrode is configured to collect myoelectricity signals of the experimental subject; the electroencephalogram electrodes comprise three paths, wherein a single-channel microwire electrode is inserted into an M1 main movement skin area on the skull of the experimental object, and the other two paths of electrodes are inserted into the nasal bone of the experimental object to serve as reference electrodes; the myoelectric electrode comprises three paths, wherein one path of electrode is inserted under the skin in the middle of the tail of the experimental object, and the other two paths of electrode are respectively inserted on the two rear claws of the experimental object to be used as reference electrodes.
In this embodiment, the acquisition frequency of the electroencephalogram and electromyogram signal acquisition processing module to the electrode module is set to 2 kHz.
In the implementation, the electrode module detects the brain muscle signal of the experimental object in the current state, the brain muscle electrical signal acquisition and processing module acquires the current brain muscle signal, processes the current brain muscle signal and sends the processed signal to the transcranial ultrasonic signal generating module, the transcranial ultrasonic signal generating module compares the current brain muscle signal with the preset expected value of the system, according to a configuration strategy preset by the system, an absolute error and a relative error obtained after the current brain muscle signal is compared with an expected value are input into a control algorithm of an implantation configuration strategy to obtain an adjustment parameter, so as to adjust and control the transcranial ultrasonic stimulation module to transmit ultrasonic stimulation signals to the experimental object next time (next period), realize the acquisition and processing of real-time electric signals, and adjusting the ultrasonic parameters by using the processing result in real time to obtain closed-loop stimulation control of transcranial brain stimulation, so that the transcranial brain stimulation control effect is good and the current control effect is converged quickly.
In a preferred embodiment, the brain-muscle electrical signal acquisition and processing module comprises a front-end amplifier, a microelectrode AC amplifier, a nerve signal processor and a first computing unit; the front-end amplifier is electrically connected with the electrode module and is used for amplifying the received brain muscle signals sent by the electrode module and sending the amplified signals to the microelectrode AC amplifier; the microelectrode AC amplifier is configured to amplify and filter the brain muscle signals and send the processed signals to the neural signal processor; the neural signal processor is configured to convert the brain muscle signals into corresponding digital signals and send the converted digital signals to the first computing unit; the first computing unit is configured to perform signal processing on the digital signal and send the processed signal to the transcranial ultrasound signal generating module.
In the preferred embodiment, the first computing unit is internally provided with a PCI-5122 digital signal acquisition card, a PCI-5412 waveform generator and a corresponding LabVIEW processing program. In the preferred embodiment, the first computing unit applies the function of a PCI-5122 digital signal acquisition card, and the signal processing process of the digital signal comprises filtering, hilbert conversion to obtain envelope, extraction of the peak value of the electroencephalogram signal and the average value of the electromyogram signal, and transmission of the peak value of the electroencephalogram signal and the average value of the electromyogram signal to the transcranial ultrasonic signal generation module. In the preferred embodiment, the Microelectrode AC Amplifier is a MicroElectrode AC Amplifier/MODEL 1800, and the neural signal processor is a Cerebus-128 neural signal processor manufactured by Blackrock Microsystems, USA.
In a preferred embodiment, the transcranial ultrasonic signal generation module comprises a second calculation unit and a radio frequency amplifier; the second computing unit receives the signal sent by the first computing unit and generates a control waveform signal according to a configuration strategy; the radio frequency amplifier amplifies the control waveform signal and sends the processed control signal to the transcranial ultrasonic stimulation module.
In the preferred embodiment, the second computing unit is internally provided with a PCI-5122 digital signal acquisition card, a PCI-5412 waveform generator and a corresponding LabVIEW processing program. In the preferred embodiment, the second computing unit applies the function of PCI-5412 waveform generator, receives the processing result from the PCI-5122 digital signal acquisition card of the first computing unit, configures the PCI-5412 waveform generator to generate corresponding waveform parameters according to the written program, and transmits the generated waveform signals from the output port, then the LabVIEW processing program of the second computing unit compares the processing result of the PCI-5122 digital signal acquisition card of the first computing unit with a set expected value, sends the absolute error and the relative error generated by the comparison into a controller (programmed controller or control algorithm), the controller calculates to obtain the waveform parameters generated by the PCI-5412 waveform generator to be generated by the transcranial ultrasonic stimulation module in the next period, and further controls the generated waveform. In the preferred embodiment, the PCI-5412 waveform generator of the second computing unit is used for displaying the processing result sent by the PCI-5122 digital signal acquisition card of the first computing unit and displaying the control signal of the next period after the LabVIEW processing program of the second computing unit is calculated, so that an experimenter can visually observe the waveform data before and after the adjustment of the second computing unit. In the preferred embodiment, the RF amplifier amplifies the signal from the PCI-5412 waveform generator. The power amplifier refers to an amplifier capable of generating maximum power output to drive a certain load under the condition of a given distortion rate, and the model of the power amplifier in the preferred embodiment is 240L ENI linear power amplifier.
In the preferred embodiment and the previous preferred embodiment, the PCI and the corresponding LabVIEW processing program are respectively arranged in the first computing unit and the second computing unit, so that the types and the volumes of experimental equipment are greatly reduced, the experimental difficulty is reduced, and the experimental equipment has a large-capacity data storage space, so that the acquired data and the generated ultrasonic data are stored, and the off-line analysis after the experiment is facilitated.
In a preferred embodiment, the transcranial ultrasound stimulation module comprises an ultrasound transducer and a collimator; the ultrasonic transducer is configured to enable the control signal sent by the radio frequency amplifier to be an ultrasonic output; the collimator is fixedly connected to the output end of the ultrasonic transducer and is configured to limit the ultrasonic output within a set range to be emitted to the experimental object.
An ultrasonic transducer is an active device that can realize a device that converts electrical power into mechanical power output, i.e., electrical energy into acoustic energy, and this process has little power loss (ultrasonic waves are mechanical waves). In the preferred embodiment, the ultrasonic transducer generates ultrasonic waves, the center frequency of the ultrasonic transducer is set to be 500kHz, the Oribas ultrasonic transducer with the diameter of 31mm is selected, the model is V301-SU, and the specific brain area of the experimental subject can be accurately stimulated through the guidance of the collimator. The collimator is a device which limits the sound wave output within a certain range, and can lead the ultrasonic waves to pointedly stimulate the target brain area of the experimental object, thereby eliminating unnecessary interference. The collimator is filled with an ultrasonic coupling agent, so that the ultrasonic can be well conducted to the skull of the experimental object.
Referring to fig. 2, a second embodiment of the present application is shown, and the present embodiment is a stimulation method using the system of the first embodiment, including the following steps:
and S1, the electrode module collects the original brain muscle signals of the experimental object and sends the signals to the brain muscle electrical signal collecting and processing module.
The method specifically comprises the following steps: the brain electric electrode is connected to a preset brain part of the test object, the myoelectric electrode is connected to a preset body part of the test object, the brain electric electrode acquires brain electric signals of the test object, and the myoelectric electrode acquires myoelectric signals of the test object.
S2, the brain-muscle electrical signal acquisition processing module carries out primary processing on the received original brain-muscle signals to obtain first brain-muscle signals, and the first brain-muscle signals are sent to the transcranial ultrasonic signal generating module.
As shown in fig. 3, the present step specifically includes the following steps:
s21, amplifying the original brain muscle signal through a front-end amplifier;
s22, carrying out differential amplifier and filtering through a microelectrode AC amplifier;
s23, converting the analog signal into a digital signal through the neural signal processor;
and S24, performing Hilbert transform after filtering by the first computing unit, and obtaining an envelope to obtain an electroencephalogram peak value and an electromyogram average value to form the first brain muscle signal.
S3, the transcranial ultrasonic signal generation module carries out data processing on the received first brain muscle signal, forms a control signal according to a configuration strategy and sends the control signal to the transcranial ultrasonic stimulation module.
The method specifically comprises the following steps:
comparing the first brain muscle signal with a set expected value to obtain an absolute error and a relative error;
and inputting the absolute error and the relative error into a control algorithm to obtain the control signal, wherein the control signal comprises a control signal for the amplitude and the duration of the ultrasonic wave.
And S4, enabling ultrasonic stimulation to the preset area of the experimental object by the transcranial ultrasonic stimulation module according to the received control signal.
The principles and embodiments of the present application are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present application. The foregoing is only a preferred embodiment of the present application, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present application, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments, or may be learned by practice of the invention.
Claims (10)
1. A closed loop transcranial brain stimulation system is characterized by comprising a transcranial ultrasonic signal generation module, a transcranial ultrasonic stimulation module, a brain electromyographic signal acquisition and processing module and an electrode module; the electrode module is electrically connected to the experimental subject and used for collecting brain muscle signals of the experimental subject; the brain electromyographic signal acquisition processing module is electrically connected with the electrode module, the transcranial ultrasonic signal generation module is electrically connected with the brain electromyographic signal acquisition processing module, and the transcranial ultrasonic stimulation module is electrically connected with the transcranial ultrasonic signal generation module;
the brain and muscle electrical signal acquisition and processing module is configured for acquiring signals of the electrode module, and sending detection signals to the transcranial ultrasonic signal generation module after signal processing;
the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module;
the transcranial ultrasound stimulation module is configured to transmit ultrasound stimulation to a subject according to a stimulation signal.
2. The closed-loop transcranial brain stimulation system according to claim 1, wherein the brain-muscle electrical signal acquisition and processing module comprises a front-end amplifier, a microelectrode AC amplifier, a nerve signal processor and a first computing unit;
the front-end amplifier is electrically connected with the electrode module and is used for amplifying the received brain muscle signals sent by the electrode module and sending the amplified signals to the microelectrode AC amplifier;
the microelectrode AC amplifier is configured to amplify and filter the brain muscle signals and send the processed signals to the neural signal processor;
the neural signal processor is configured to convert the brain muscle signals into corresponding digital signals and send the converted digital signals to the first computing unit;
the first computing unit is configured to perform signal processing on the digital signal and send the processed signal to the transcranial ultrasound signal generating module.
3. The closed-loop transcranial brain stimulation system according to claim 2, wherein the transcranial ultrasound signal generation module comprises a second computing unit and a radio frequency amplifier;
the second computing unit receives the signal sent by the first computing unit and generates a control waveform signal according to a configuration strategy;
the radio frequency amplifier amplifies the control waveform signal and sends the processed control signal to the transcranial ultrasonic stimulation module.
4. The closed-loop transcranial brain stimulation system according to claim 3, wherein the transcranial ultrasound stimulation module includes an ultrasound transducer and a collimator;
the ultrasonic transducer is configured to enable the control signal sent by the radio frequency amplifier to be an ultrasonic output;
the collimator is fixedly connected to the output end of the ultrasonic transducer and is configured to limit the ultrasonic output within a set range to be emitted to the experimental object.
5. The closed-loop transcranial brain stimulation system according to claim 4, wherein the electrode module comprises an electroencephalogram electrode and a myoelectric electrode, the electroencephalogram electrode is configured for collecting electroencephalogram signals of the experimental subject, and the myoelectric electrode is configured for collecting myoelectric signals of the experimental subject;
the electroencephalogram electrodes comprise three paths, wherein one path of electrode is inserted into the skull of the experimental object, and the other two paths of electrodes are inserted into the nasal bone of the experimental object to serve as reference electrodes;
the myoelectric electrode comprises three paths, wherein one path of electrode is inserted under the skin in the middle of the tail of the experimental object, and the other two paths of electrode are respectively inserted on the two rear claws of the experimental object to be used as reference electrodes.
6. The closed-loop transcranial brain stimulation system according to claim 5, wherein the first computing unit and the second computing unit are each internally provided with a PCI-5122 digital signal acquisition card and a PCI-5412 waveform generator.
7. A closed-loop transcranial brain stimulation method applying the system of any one of claims 1-6, comprising the steps of:
the electrode module collects original brain muscle signals of an experimental object and sends the signals to the brain muscle electrical signal collecting and processing module;
the brain-muscle electrical signal acquisition processing module carries out primary processing on the received original brain-muscle signals to obtain first brain-muscle signals, and the first brain-muscle signals are sent to the transcranial ultrasonic signal generating module;
the transcranial ultrasonic signal generation module carries out data processing on the received first brain muscle signal, forms a control signal according to a configuration strategy and sends the control signal to the transcranial ultrasonic stimulation module;
the transcranial ultrasonic stimulation module enables ultrasonic stimulation to a preset area of the experimental object according to the received control signal.
8. The closed-loop transcranial brain stimulation method according to claim 7, wherein the electrode module collects raw brain muscle signals of a subject, and specifically comprises: the brain electric electrode is connected to a preset brain part of the test object, the myoelectric electrode is connected to a preset body part of the test object, the brain electric electrode acquires brain electric signals of the test object, and the myoelectric electrode acquires myoelectric signals of the test object.
9. The closed-loop transcranial brain stimulation method according to claim 8, wherein the brain-muscle electrical signal acquisition and processing module performs preliminary processing on the received original brain-muscle signal to obtain a first brain-muscle signal, and specifically comprises the following steps:
the original brain muscle signal is amplified through a front-end amplifier;
carrying out differential amplifier and filtering by a microelectrode AC amplifier;
converting the analog signal into a digital signal by a neural signal processor;
and performing Hilbert transform after filtering by a first computing unit, and obtaining an envelope to obtain an electroencephalogram peak value and an electromyogram average value to form the first brain muscle signal.
10. The closed-loop transcranial brain stimulation method according to claim 9, wherein the transcranial ultrasound signal generation module performs data processing on the received first brain muscle signal and forms a control signal according to a configuration strategy, and specifically comprises the following steps:
comparing the first brain muscle signal with a set expected value to obtain an absolute error and a relative error;
and inputting the absolute error and the relative error into a control algorithm to obtain the control signal, wherein the control signal comprises a control signal for the amplitude and the duration of the ultrasonic wave.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110457551.0A CN113181569B (en) | 2021-04-27 | 2021-04-27 | Closed-loop transcranial brain stimulation system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110457551.0A CN113181569B (en) | 2021-04-27 | 2021-04-27 | Closed-loop transcranial brain stimulation system and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113181569A true CN113181569A (en) | 2021-07-30 |
| CN113181569B CN113181569B (en) | 2023-03-14 |
Family
ID=76979215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110457551.0A Active CN113181569B (en) | 2021-04-27 | 2021-04-27 | Closed-loop transcranial brain stimulation system and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113181569B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113967023A (en) * | 2021-10-27 | 2022-01-25 | 复旦大学 | Closed-loop optogenetic intervention system and intervention method |
| CN114404825A (en) * | 2022-01-26 | 2022-04-29 | 燕山大学 | Sleep closed-loop transcranial brain stimulation method and system |
| CN114711745A (en) * | 2022-05-06 | 2022-07-08 | 燕山大学 | Neurovascular signal detection device |
| CN114847972A (en) * | 2022-04-25 | 2022-08-05 | 燕山大学 | Transcranial brain stimulation multichannel data acquisition system and method |
| CN114917495A (en) * | 2022-04-28 | 2022-08-19 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
| CN115153528A (en) * | 2022-07-29 | 2022-10-11 | 燕山大学 | System and method for noninvasive stimulation and detection of whole brain network connection |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857640A (en) * | 2015-04-22 | 2015-08-26 | 燕山大学 | Closed-loop type transcranial ultrasonic brain stimulation apparatus |
| CN106037723A (en) * | 2016-05-17 | 2016-10-26 | 西安交通大学 | Brain electrophysiological signal recording device and method for transcranial ultrasonic nerve stimulation |
| CN109924976A (en) * | 2019-04-29 | 2019-06-25 | 燕山大学 | The stimulation of mouse TCD,transcranial Doppler and brain electromyography signal synchronous |
| CN111407257A (en) * | 2020-03-27 | 2020-07-14 | 中国医学科学院生物医学工程研究所 | Device for synchronously acquiring animal intracranial nerve electrical signals under transcranial ultrasonic action |
| CN111477299A (en) * | 2020-04-08 | 2020-07-31 | 广州艾博润医疗科技有限公司 | Method and device for regulating and controlling sound-electricity stimulation nerves by combining electroencephalogram detection and analysis control |
| CN112402791A (en) * | 2020-11-04 | 2021-02-26 | 深圳中科华意科技有限公司 | Nerve regulation and control device and method |
-
2021
- 2021-04-27 CN CN202110457551.0A patent/CN113181569B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857640A (en) * | 2015-04-22 | 2015-08-26 | 燕山大学 | Closed-loop type transcranial ultrasonic brain stimulation apparatus |
| CN106037723A (en) * | 2016-05-17 | 2016-10-26 | 西安交通大学 | Brain electrophysiological signal recording device and method for transcranial ultrasonic nerve stimulation |
| CN109924976A (en) * | 2019-04-29 | 2019-06-25 | 燕山大学 | The stimulation of mouse TCD,transcranial Doppler and brain electromyography signal synchronous |
| CN111407257A (en) * | 2020-03-27 | 2020-07-14 | 中国医学科学院生物医学工程研究所 | Device for synchronously acquiring animal intracranial nerve electrical signals under transcranial ultrasonic action |
| CN111477299A (en) * | 2020-04-08 | 2020-07-31 | 广州艾博润医疗科技有限公司 | Method and device for regulating and controlling sound-electricity stimulation nerves by combining electroencephalogram detection and analysis control |
| CN112402791A (en) * | 2020-11-04 | 2021-02-26 | 深圳中科华意科技有限公司 | Nerve regulation and control device and method |
Non-Patent Citations (3)
| Title |
|---|
| 张岩等: "植入式神经刺激器刺激信号的产生和调节技术", 《中国医疗器械杂志》 * |
| 张慧河等: "基于肌电样本熵的反馈式电刺激仪的研究", 《电子测量技术》 * |
| 徐秀林等: "基于单片机控制的脑卒中康复治疗仪的设计", 《微计算机信息》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113967023A (en) * | 2021-10-27 | 2022-01-25 | 复旦大学 | Closed-loop optogenetic intervention system and intervention method |
| CN113967023B (en) * | 2021-10-27 | 2023-08-29 | 复旦大学 | Closed-loop optogenetic intervention system and intervention method |
| CN114404825A (en) * | 2022-01-26 | 2022-04-29 | 燕山大学 | Sleep closed-loop transcranial brain stimulation method and system |
| CN114847972A (en) * | 2022-04-25 | 2022-08-05 | 燕山大学 | Transcranial brain stimulation multichannel data acquisition system and method |
| CN114847972B (en) * | 2022-04-25 | 2024-05-10 | 燕山大学 | Transcranial brain stimulation multichannel data acquisition system and method |
| CN114917495A (en) * | 2022-04-28 | 2022-08-19 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
| CN114711745A (en) * | 2022-05-06 | 2022-07-08 | 燕山大学 | Neurovascular signal detection device |
| CN115153528A (en) * | 2022-07-29 | 2022-10-11 | 燕山大学 | System and method for noninvasive stimulation and detection of whole brain network connection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113181569B (en) | 2023-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113181569B (en) | Closed-loop transcranial brain stimulation system and method | |
| CN109924976A (en) | The stimulation of mouse TCD,transcranial Doppler and brain electromyography signal synchronous | |
| US20050261601A1 (en) | Method and system for processing neuro-electrical waveform signals | |
| US20150148710A1 (en) | Ultrasound Modulation of the Brain for Treatment of Stroke, Brain Injury, and Other Neurological Disorders | |
| CN101244312B (en) | Implantation type self-feedback regulating nerve muscle electrostimulation system | |
| US20120116741A1 (en) | Systems and methods of constructing a patient specific neural electrical stimulation model | |
| CN102793980B (en) | Double-frequency focused ultrasound system | |
| IL139917A (en) | Augmentation of muscle contractility by biphasic stimulation | |
| CN108144199A (en) | Device, method and system are motivated by ultrasound | |
| CN112402792A (en) | Nerve regulation and control device and method | |
| Jezernik et al. | Energy-optimal electrical excitation of nerve fibers | |
| CN105251141A (en) | Closed-loop transcranial magnetoacoustic stimulation device | |
| JP2022510162A (en) | Device network for regulating neural activity | |
| CN104857640A (en) | Closed-loop type transcranial ultrasonic brain stimulation apparatus | |
| JP5577402B2 (en) | Method and apparatus for cerebral cortical electrical stimulation | |
| CN105536156A (en) | Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof | |
| CN115137980B (en) | Percutaneous nerve electrical stimulation device synchronized with gastrointestinal electricity and method thereof | |
| CN111317558A (en) | Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field | |
| CN115920235A (en) | Wireless nerve regulation and control system and method based on ultrasonic drive piezoelectric material | |
| CN116549845A (en) | Stimulator, electronic device, and computer-readable storage medium | |
| CN114404825A (en) | Sleep closed-loop transcranial brain stimulation method and system | |
| CN109011141A (en) | Single two-phase constant current egersimeter for rat brain | |
| CN113017821A (en) | Cardiac pacing and irreversible electroporation (IRE) combination therapy | |
| CN111013015A (en) | Self-feedback physiotherapy instrument | |
| CN114847972B (en) | Transcranial brain stimulation multichannel data acquisition system and method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |