CN113181556B - Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector - Google Patents

Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector Download PDF

Info

Publication number
CN113181556B
CN113181556B CN202110482220.2A CN202110482220A CN113181556B CN 113181556 B CN113181556 B CN 113181556B CN 202110482220 A CN202110482220 A CN 202110482220A CN 113181556 B CN113181556 B CN 113181556B
Authority
CN
China
Prior art keywords
medium substrate
insulating medium
effector
metal plate
groove
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202110482220.2A
Other languages
Chinese (zh)
Other versions
CN113181556A (en
Inventor
朱湘琴
杜太焦
陈昌华
宋志敏
蔡利兵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwest Institute of Nuclear Technology
Original Assignee
Northwest Institute of Nuclear Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwest Institute of Nuclear Technology filed Critical Northwest Institute of Nuclear Technology
Priority to CN202110482220.2A priority Critical patent/CN113181556B/en
Publication of CN113181556A publication Critical patent/CN113181556A/en
Application granted granted Critical
Publication of CN113181556B publication Critical patent/CN113181556B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Micromachines (AREA)

Abstract

The invention relates to an irradiation cavity, in particular to an irradiation cavity based on a medium substrate structure for enhancing the field intensity in a large effector. The problem of low feasibility of the existing radiation cavity improvement means is solved. According to the invention, the insulating medium substrate with a specific relative dielectric constant is placed in the irradiation cavity, the groove with a specific shape and a specific size is engraved on the insulating medium substrate, and then the metal material with a specific shape and a specific size is filled, so that the field intensity enhancement inside the large-scale nonmetal effect object is realized, and the improvement of the irradiation cavity structure is completed.

Description

Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector
Technical Field
The invention relates to an irradiation cavity, in particular to an irradiation cavity based on a medium substrate structure, which is used for enhancing the internal field intensity of a large-scale nonmetal effector.
Background
The blood-brain barrier (BBB) structure, which is composed of endothelial cells, pericytes, basement membranes and astrocyte terminal feet of capillaries and microvasculature, is one of the most complex and important barriers in the brain. The BBB structure has a strict permselectivity mechanism for various substances in the circulating blood, so as to ensure high stability of the brain environment and facilitate functional activities of the central nervous system. However, while the BBB can prevent foreign substances (including microorganisms, viruses, etc.) from invading brain tissue to achieve a protective effect, it also prevents therapeutic drugs from entering brain lesion areas (Kangchu Li et al, BioElectromagnetics, journal 2018, vol.39, page 60, "EMP-induced BBB-differentiation processes driver to glucose and microorganisms treatment effects in rates"). Therefore, for the central nervous system diseases, the effective absorption of the drug is difficult to realize due to the existence of BBB, and the effective implementation of the drug treatment of the brain diseases is seriously restricted. However, it is known from many years of research that irradiation with strong electromagnetic pulses can produce significant biological Effects (Mingjuan Yang et al, published in "theriology" journal 2013, volume 80, page 18, "Effects of electromagnetic pulses on polymeric forms of patients), and BBB structures can be opened to complete drug absorption in diseased regions (Wangchen et al, published in" J.Ouchi "journal 2003, volume 7, phase 5, page 404," dose-effect relationship of pulsed electromagnetic radiation on blood brain barrier of rats ").
On the other hand, an irradiation cavity having the same structure as a bounded wave simulator (Zhouyua et al, journal 2011 of the journal of the institute of Electrical wave science, Vol. 26, No. 6, page 1034, calibration research of a lightning electromagnetic pulse electric field instrument) can provide a uniform field in a working space. Considering that lesion areas of some brain diseases (such as glioma, alzheimer disease and the like) of human brains and brains of large animals (such as pigs, cows and the like) are not a little bit areas of the brains and are likely to be distributed in a large area of the brains, in order to open a BBB structure of the large lesion area, the whole large lesion area needs to be irradiated by strong electromagnetic pulses. In addition, considering that the human brain or the brain of a large animal placed in the working space of the irradiation cavity belongs to a large-scale non-metal effector compared with the brain of a small animal (such as a mouse, a rabbit, etc.), it is necessary to design the irradiation cavity in an improved way to enhance the internal field strength of the large-scale non-metal effector in the irradiation cavity.
At present, besides conventional radiation cavity improvement means such as ' reducing the distance between an upper metal plate and a lower metal plate in a working space of a radiation cavity ' and ' increasing the voltage peak value of an excitation source of the radiation cavity ', Chenchanghua et al also propose ' using an insulating medium block and an insulating medium sleeve with specific insulating medium parameters and specific sizes ' in the radiation cavity ' to improve the radiation cavity (Chenchanghua et al, patent number ZL201811527792.2, invented name of ' a device for globally enhancing the internal field intensity of a large-scale non-metal effect object in the radiation cavity ').
When the irradiation cavity is improved by simply reducing the distance between the upper metal plate and the lower metal plate in the working space of the irradiation cavity, the reduction of the distance between the upper metal plate and the lower metal plate in the working space is limited by the maximum height of an effector; when improvement is carried out by increasing the voltage peak value of the excitation source of the irradiation cavity, the design difficulty of a voltage source is increased; when the improvement is made by using the ' insulating dielectric block and insulating dielectric sleeve with specific insulating dielectric parameters and specific dimensions ' in the irradiation cavity ' proposed by chenchanghua et al, the height of the insulating dielectric block is limited by the maximum height of the effector.
Disclosure of Invention
The invention aims to provide an irradiation cavity based on a medium substrate structure for enhancing the internal field intensity of a large-scale effector, and solves the problem of low feasibility of ' adopting a conventional irradiation cavity improvement means and adopting an ' irradiation cavity improvement mode of using an insulating medium block and an insulating medium sleeve with specific insulating medium parameters and specific sizes ' in the irradiation cavity, which is proposed by Chengchang et al.
The conception of the invention is as follows:
when the theory that the incident electromagnetic wave totally penetrates through the metal wire, the electromagnetic wave is locally enhanced on the surface of the metal thin conductor, the electromagnetic wave is totally reflected on the surface of the metal thin conductor, the irradiation cavity with the aim of enhancing the internal field intensity of the large-scale nonmetal effect is improved on the basis of the theory that the electromagnetic wave is reflected and refracted on the surface of an insulating medium and the like is adopted, the phenomenon that the field inside the large-scale nonmetal effect is enhanced when a left-side medium substrate structure which is provided with a cuboid or square-shaped groove and a cuboid-shaped metal strip parallel to the width direction of the irradiation cavity is arranged on one side of an effect object facing an excitation source in the irradiation cavity and a right-side medium substrate structure which is provided with a cylindrical groove and filled with metal in the groove are arranged on one side of the effect object facing away from the excitation source is found, the feasibility of field intensity enhancement implementation is better than the conventional radiation cavity improvement means such as reducing the distance between an upper metal plate and a lower metal plate in the working space of the radiation cavity, increasing the voltage peak value of an excitation source of the radiation cavity and the like to a certain extent, and is also better than the radiation cavity improvement mode of using an insulating medium block and an insulating medium sleeve with specific insulating medium parameters and specific sizes in the radiation cavity, which is proposed by Chengchang et al, so that a new idea of radiation cavity improvement design based on a medium substrate structure, which can enhance the field intensity in a large-scale nonmetal effect object, is provided. The invention is also suitable for the condition that the material of the large effector in the irradiation cavity is anisotropic.
The technical scheme of the invention is to provide an irradiation cavity based on a medium substrate structure for enhancing the internal field intensity of a large-scale nonmetal effector, which comprises an upper metal plate and a lower metal plate which are parallel to each other, and is characterized in that:
defining a space which is positioned between the upper metal plate and the lower metal plate and is positioned in the irradiation cavity as an irradiation cavity working space;
defining the horizontal direction from an excitation source of an irradiation cavity to a working space of the irradiation cavity as a length direction, namely a + x direction, the relative direction of an upper metal plate and a lower metal plate as a height direction, namely a +/-z direction, and the direction vertical to both the length direction and the height direction as a width direction, namely a +/-y direction; defining one side of the effector, which is close to the excitation source in the length direction, as the left side of the effector, and the corresponding side far away from the excitation source as the right side of the effector;
the device also comprises a left side insulating medium substrate and a right side insulating medium substrate;
the left side insulating medium substrate is an insulating medium flat plate which is arranged in the working space of the irradiation cavity, is orthogonal to the upper metal plate and the lower metal plate and is positioned on the left side of the effector;
setting the area of z >0 above the height center in the irradiation cavity working space as an upper working space and the area of z <0 below as a lower working space;
defining the surface of the left side insulating medium substrate facing to the excitation source as the left surface of the left side insulating medium substrate, and forming a plurality of first grooves in the shape of cuboids or squares on the left surface; wherein, a part of the first grooves are uniformly distributed on the upper half part of the left insulating medium substrate with z >0, namely, the first grooves are positioned in the upper working space; the other part of the first grooves are uniformly distributed on the lower half part of the left insulating medium substrate, namely the lower working space, wherein z is less than 0;
an upper wall surface in the first groove, which is parallel to the upper metal plate and the lower metal plate, is set as a groove top, and a lower wall surface is set as a groove bottom;
cuboid-shaped metal strips are adhered to the top of the first groove in the upper working space and the bottom of the first groove in the lower working space; the size of the metal strip in the length direction and the size of the metal strip in the width direction of the cuboid are respectively equal to the size of the first groove in the length direction and the size of the metal strip in the width direction, and the size of the metal strip in the height direction is smaller than the size of the metal strip in the height direction of the first groove;
the right side insulating medium substrate is an insulating medium flat plate which is arranged in the working space of the irradiation cavity, is orthogonal to the upper metal plate and the lower metal plate and is positioned on the right side of the effector;
defining the surface of one side of the right side insulating medium substrate facing the excitation source as the left surface of the right side insulating medium substrate, and forming a plurality of second cylindrical grooves on the left surface; wherein, a part of the second grooves are uniformly distributed on the upper half part of the right insulating medium substrate with z >0, namely the second grooves are positioned in the upper working space; the other part of the second grooves are uniformly distributed on the lower half part of the right insulating medium substrate with z <0, namely, the second grooves are positioned in the lower working space;
the second groove is filled with a metal cylinder with the same shape and size as the second groove.
Further, the width direction size of the left side insulating medium substrate is the same as the width of the upper metal plate and the lower metal plate, and the height direction size is the same as the distance between the upper metal plate and the lower metal plate;
the width direction size of the right side insulating medium substrate is the same as the width of the upper metal plate and the lower metal plate, and the height direction size is the same as the distance between the upper metal plate and the lower metal plate.
Furthermore, the maximum dimension of the left side insulating medium substrate in the length direction after notching is 20-22 mm, and the minimum dimension is 8-10 mm.
Furthermore, the maximum dimension of the right side insulating medium substrate in the length direction after grooving is 28-32 mm, and the minimum dimension is 20-25 mm.
Furthermore, the centers of the left side insulating medium substrate and the right side insulating medium substrate are both positioned on the x axis, and the center of the effector in the z direction is positioned on the connecting line of the centers of the left side insulating medium substrate and the right side insulating medium substrate as much as possible, namely the x axis;
defining the surface of one side of the left side insulating medium substrate facing the effector as the right surface of the left side insulating medium substrate, wherein the minimum x-direction distance between the right surface and the effector is 15-20 mm; the minimum x-direction distance between the left surface of the right side insulating medium substrate and the effector is 15-20 mm.
Further, the metal bar in the rectangular parallelepiped shape has a dimension in the height direction of 3 to 5 mm.
Further, the first grooves and the second grooves are arranged in a two-dimensional array.
Further, defining the distance between the centers of the adjacent first grooves in the upper working space in the width direction and the height direction as d y1 And d z1 (ii) a The distance between the centers of the adjacent first grooves in the lower working space in the width direction and the height direction is also d y1 And d z1
The distance between the centers of two adjacent upper and lower rows of first grooves, which are "symmetrical about the plane z-0 and closest to the plane z-0", in the z direction is defined as L z1
Then L is z1 ﹥d z1
Defining the distance between the centers of the adjacent second grooves in the upper working space in the width direction and the height direction as d y2 And d z2 (ii) a The distance between the centers of the adjacent second grooves in the lower working space in the width direction and the height direction is also d y2 And d z2
The distance between the centers of two adjacent upper and lower rows of second grooves, which are "symmetrical about the plane z-0 and closest to the plane z-0", in the z direction is defined as L z2
Then L is z2 ﹥d z2
Further, a mixed structure of a left side dielectric substrate and a metal strip which is provided with a first groove on the left surface of the left side insulating dielectric substrate and is in a cuboid shape and attached in the first groove is defined as a left side dielectric substrate structure; defining a mixed structure of forming a second groove on the left surface of the right-side insulating medium substrate and filling a metal cylinder in the second groove as a right-side medium substrate structure;
the relative dielectric constants of the left side insulating medium substrate and the right side insulating medium substrate are the same and are epsilon r The optimal solution of the method is composed of the shape and size of the first groove contained in the left dielectric substrate structure and d y1 、d z1 、L z1 Dimension of the second groove contained in the right dielectric substrate structure, d y2 、d z2 、L z2 And the input electromagnetic pulse source.
Further, the structure after the first groove is formed on the left surface of the left side insulating medium substrate and the structure after the second groove is formed on the left surface of the right side insulating medium substrate are both formed by plastic molds with the same shape, and the interiors of the molds are filled with and encapsulated with glycerin; the metal strip of cuboid shape is fixed in first recess through the mode that bonds, and the metal cylinder is inlayed and is inlayed in the second recess.
The invention has the beneficial effects that:
(1) considering that "when the electric field direction of the incident electromagnetic wave is perpendicular to the metal wire direction, the incident electromagnetic wave will totally penetrate the metal wire", "the electric field of the electromagnetic wave on the surface of the metal thin conductor is locally enhanced", and "the electromagnetic wave will be totally reflected on the metal surface and will be reflected and refracted on the surface of the insulating medium", a left dielectric substrate structure which is provided with a cuboid or cuboid groove and a cuboid metal strip parallel to the width direction of the irradiation cavity is arranged on one side of the 'effector facing the excitation source' in the irradiation cavity, a right-side medium substrate structure which is provided with a cylindrical groove and filled with metal is arranged on one side of the 'effector back to the excitation source' in the irradiation cavity, so that the field intensity inside the large-scale nonmetal effector is enhanced, and the improvement of the irradiation cavity structure is completed;
(2) according to the input electromagnetic pulse source, "the shape and size of the groove contained in the left dielectric substrate structure", "the distance between the centers of the adjacent grooves in the 'upper working space' or 'lower working space' of the irradiation chamber in the width direction and the height direction", "the distance between the centers of the upper and lower rows of adjacent grooves on the left dielectric substrate structure, which are symmetrical about the height center and are respectively closest to the height center", "the size of the groove contained in the right dielectric substrate structure", "the distance between the centers of the adjacent grooves in the 'upper working space' or 'lower working space' of the irradiation chamber on the right dielectric substrate structure, which are symmetrical about the height center" and are respectively closest to the height center ", and" the distance between the centers of the adjacent grooves on the right dielectric substrate structure, which are symmetrical about the height center and are respectively closest to the height center And after scanning optimization calculation is carried out on the distance between the centers of the next two rows of adjacent grooves in the height direction, scanning optimization calculation is carried out on the medium parameters of the two insulating medium substrates with the same medium parameters, and an optimal solution is obtained. The two are combined, further, the field intensity inside the large-scale nonmetal effector in the irradiation cavity is enhanced, and the improvement of the irradiation cavity is completed;
(3) the invention is equally applicable when the large effector is an anisotropic material.
Drawings
FIG. 1 is a projection view of an irradiation cavity with a large-scale non-metallic effect object and a medium substrate structure on the left side and the right side on the xoz plane.
In the figure: A. b, C and D are the 4 station positions inside the effector on the xoz plane, respectively.
FIG. 2 is a projection of the surface of the left dielectric substrate structure facing the excitation source on the yoz plane.
In the figure: d y1 The distance between the centers of the adjacent first grooves in the width direction (namely +/-y direction) which are positioned on the projection plane and positioned in the upper working space or the lower working space of the irradiation cavity; d z1 The distance between the centers of the adjacent first grooves on the projection plane in the height direction (i.e., +/-z direction); l is a radical of an alcohol z1 The distance between the centers of the upper and lower rows of adjacent first grooves which are symmetrical about the plane z-0 and closest to the plane z-0 in the z direction is shown.
FIG. 3 is a projection of the surface of the right media substrate structure facing the excitation source on the yoz plane.
In the figure: d y2 The distance between the centers of the adjacent second grooves in the width direction (i.e., +/-y direction) which are positioned on the projection plane and positioned in the upper working space or the lower working space of the irradiation cavity; d z2 The distance between the centers of the adjacent second grooves on the projection plane in the height direction (i.e., +/-z direction); l is a radical of an alcohol z2 The distance between the centers of the upper and lower rows of adjacent second grooves which are "symmetrical about the z-0 plane and closest to the z-0 plane" in the z direction is shown.
The reference numbers in the figures are: 1-the position of an excitation source of an irradiation cavity, 2-an upper metal plate, 3-a lower metal plate, 4-a front inclined section of the irradiation cavity, 5-a rear transition section of the irradiation cavity, 6-a large-scale non-metal effect, 7-a left side insulating medium substrate, 8-a rectangular metal strip, 9-an air area, 10-a right side insulating medium substrate and 11-a metal cylinder.
Detailed Description
In order to realize the improvement of the irradiation cavity aiming at enhancing the internal field intensity of the large-scale nonmetal effector, the invention places an insulating medium substrate with specific relative dielectric constant in the irradiation cavity, carves a groove with specific shape and size on the insulating medium substrate, and then fills a metal material with specific shape and size, thereby realizing the improved design of the irradiation cavity based on the medium substrate structure, which can enhance the internal field intensity of the large-scale nonmetal effector. The invention is further illustrated by the following examples in conjunction with the accompanying drawings.
FIG. 1 is a projection view of an irradiation cavity on the plane xoz in the presence of a large non-metallic effector and a dielectric substrate structure on the left and right sides according to an embodiment of the present invention. As shown in fig. 1: the structure of the irradiation cavity comprises an upper metal plate 2, a lower metal plate 3, a front inclined section 4 of the irradiation cavity and a rear transition section 5 of the irradiation cavity. The large-scale non-metallic effect object 6 is positioned in the working space of the irradiation cavity. The reference number 1 in the figure is the position of the excitation source of the irradiation cavity.
Establishing a space coordinate system in the irradiation cavity, wherein the origin o of coordinates is positioned at the central position of the working space of the irradiation cavity; the horizontal direction from the excitation source of the irradiation cavity to the working space of the irradiation cavity is the + x direction and can be defined as the length direction; the relative direction of the upper metal plate 2 and the lower metal plate 3 with the irradiation cavities parallel to each other is the +/-z direction, and can be defined as the height direction; the direction perpendicular to both the x-direction and the z-direction is the ± y-direction, defined as the width direction. In the embodiment, the width of the working space of the irradiation cavity in the y direction is 500mm, the length of the irradiation cavity in the x direction is 500mm, and the height of the irradiation cavity in the z direction is 410 mm; the large nonmetal effector 6 is composed of an insulating medium cylinder with the radius of 104mm and the size of 200mm in the y direction, and the y direction center of the large nonmetal effector 6 is positioned at the position where y is 0; the relative dielectric constant of the large non-metallic effector 6 is 50. A left side medium substrate structure exists on one side of the large nonmetal effector 6 close to the excitation source; defining the surface of one side, facing the excitation source, of the left insulating medium substrate 7 as the left surface of the left insulating medium substrate 7, etching a groove on the left surface, and defining the groove as a first groove; at the top of the first groove located in the upper region where z >0, a metal strip 8 in the shape of a rectangular parallelepiped is attached, and at the bottom of the first groove located in the lower region where z <0, a metal strip 8 in the shape of a rectangular parallelepiped is attached. In the figure, reference numeral 9 denotes an air region 9 remaining after the first groove is filled with a metal strip 8 having a rectangular parallelepiped shape. The side of the large nonmetal effector 6 far away from the excitation source has a 'right side medium substrate structure'; defining the surface of the right side insulating medium substrate 10 facing the excitation source as the left surface of the right side insulating medium substrate 10, engraving a cylindrical groove on the left surface, defining the groove as a second groove, and filling the second groove with a metal cylinder 11; A. b, C and D are the positions of 4 measuring points on the xoz plane inside the large-scale nonmetal effector 6.
FIG. 2 is a projection of the surface of the left media substrate structure facing the excitation source in the yoz plane, according to an embodiment of the present invention. As shown in fig. 2: a plurality of first grooves in the shape of cuboids or cubes are two-dimensionally arranged on the left insulating medium substrate 7; the sizes of the cuboid-shaped metal strips 8 attached to the top and the bottom of the first groove in the x direction and the y direction are equal to the sizes of the first groove in the x direction and the y direction respectively; the height direction dimension is smaller than the first groove height direction dimension, so that after the rectangular metal strip 8 is fixed, the air area 9 is reserved. The distance between the centers of the adjacent first grooves on the yoz projection plane and in the upper working space or the lower working space of the irradiation cavity in the width direction (i.e. the y direction) and the height direction (i.e. the z direction) is d y1 And d z1 On the left insulating dielectric substrate 7, the distance between the centers of two adjacent upper and lower rows of first grooves "symmetrical about the plane" z ═ 0 and closest to the plane "z ═ 0" in the z direction is L z1
FIG. 3 is a projection of the surface of the right media substrate structure facing the excitation source in the yoz plane, according to an embodiment of the present invention. As shown in fig. 3: a plurality of cylindrical second grooves are two-dimensionally arranged on the right insulating medium substrate 10, and the second grooves are filled with the metal cylinder 11; the distance between the centers of the adjacent second grooves which are positioned on the yoz projection plane and positioned in the upper working space or the lower working space of the irradiation cavity in the width direction (namely, the y direction) and the height direction (namely, the z direction) is d y2 And d z2 On the right insulating dielectric substrate 10, "symmetrical about the plane z equal to 0, and closest to the plane z equal to 0", the centers of two upper and lower rows of adjacent second grooves have a distance L in the z direction z2
The 4 measuring points A, B, C and D in the large-scale non-metal effector 6 on the xoy plane are respectively selected as test points, and the points a ', B', C 'and D' corresponding to the 4 measuring points A, B, C and D on the plane y equal to 80mm are respectively selected as test points. Considering that the entire model is symmetrical about a plane where y is 0, the field on the plane where y is 80mm is the same as on the plane where y is-80 mm. Gaussian pulses with the highest frequency of about 120MHz are added to the front end of the irradiation cavity, and the peak value of the pulses is 200 MV.
The concrete links are introduced as follows:
(1) defining a horizontal direction (namely + x direction) from an excitation source of an irradiation cavity to a working space of the irradiation cavity as a length direction, wherein the relative direction (namely +/-z direction) of an upper metal plate 2 and a lower metal plate 3 which are parallel to each other in the working space of the irradiation cavity is a height direction, and the direction which is vertical to both the length direction and the height direction is a width direction (namely +/-y direction); the z-direction center of the large-scale nonmetal effector 6 is placed near the center position of the height direction of the working space of the irradiation cavity as much as possible.
(2) And in the length direction, the side of the large-scale nonmetal effector 6 close to the excitation source is the left side of the large-scale nonmetal effector, and the corresponding side far away from the excitation source is the right side of the large-scale nonmetal effector. An insulating medium flat plate (called as a 'left insulating medium substrate 7') is arranged at the left side of the large nonmetal effector 6 in the working space of the irradiation cavity, the width of the insulating medium flat plate is the same as that of the upper metal plate 2 and the lower metal plate 3, and the height of the insulating medium flat plate is the same as that of the space between the upper metal plate 2 and the lower metal plate 3. Based on the left insulating dielectric substrate 7, a scheme of constructing a "left dielectric substrate structure" is as follows:
(a) placing the left side insulating dielectric substrate 7 as close to the left side of the effector as possible; the surface of the side, facing the effector, of the left side insulating medium substrate 7 is defined as the right surface of the left side insulating medium substrate, and the minimum x-direction distance between the right surface and the effector is 15-20 mm.
(b) Defining the surface of the left side insulating medium substrate 7 facing the excitation source as the left surface of the left side insulating medium substrate 7, uniformly carving grooves from the vicinity of the height center (z ═ 0) of the left side insulating medium substrate 7 to the upper part of z >0 and the lower part of z <0 respectively on the left surface, and defining the grooves as first grooves;
setting the area of z >0 above the height center of the irradiation cavity working space as an upper working space and the area of z <0 below as a lower working space;
the first groove is cuboid or cube, and the notch positionOn the left surface of the left insulating dielectric substrate 7; on the yoz projection plane, the distance between the centers of the adjacent first grooves in the "upper working space" or the "lower working space" in the width direction (i.e. + -. y direction) and the height direction (i.e. + -. z direction) is d y1 And d z1 The distance between the centers of two adjacent upper and lower rows of first grooves, which are "symmetrical about the plane z equal to 0 and closest to the plane z equal to 0", in the z direction is L z1 (ii) a The maximum size of the left side insulating medium substrate 7 after grooving in the x direction is about 20-22 mm, and the minimum size is about 8-10 mm.
(c) An upper groove wall parallel to the upper metal plate 2 and the lower metal plate 3 in the first groove is a groove top, a lower groove wall is a groove bottom, and cuboid-shaped metal strips 8 parallel to the width direction are attached to the groove top in the upper working space and the groove bottom in the lower working space on the left insulating medium substrate 7 respectively. The size of the metal strip 8 in the length direction and the size of the metal strip in the width direction of the cuboid are respectively consistent with the size of the first groove in the length direction and the size of the first groove in the width direction, and the size of the metal strip in the height direction is smaller than the size of the first groove and is about 3-5 mm.
(3) A flat insulating dielectric plate (called as a 'right insulating dielectric substrate 10') is added on the right side of the large nonmetal effector 6. The width of the insulating medium flat plate is the same as the width of the upper metal plate 2 and the lower metal plate 3, and the height is the same as the distance between the upper metal plate 2 and the lower metal plate 3. Based on the right side insulating dielectric substrate 10, a scheme of constructing a "right side dielectric substrate structure" is as follows:
(a) placing the right side insulating dielectric substrate 10 as close as possible to the right side of the effector; the surface of the right side insulating medium substrate 10 facing the effector is defined as the left surface of the right side insulating medium substrate 10, and the minimum x-direction distance between the left surface and the effector is 15-20 mm.
(b) On the left surface of the right insulating dielectric substrate 10, starting from the vicinity of the position where the height center z of the right insulating dielectric substrate 10 is 0, the directions z are respectively directed>0 upper and z<Uniformly carving a groove below 0, and defining the groove as a second groove; the second groove is in the shape of a cylinder, and the notch is positioned on the left surface of the right insulating medium substrate 10On the surface; on the yoz projection plane, the distance between the centers of the adjacent second grooves in the upper working space or the lower working space in the width direction (i.e. + -. y direction) and the height direction (i.e. + -. z direction) is d y2 And d z2 The distance between the centers of two adjacent upper and lower rows of second grooves, which are "symmetrical about the plane z equal to 0 and closest to the plane z equal to 0", in the z direction is L z2 (ii) a The maximum dimension of the right side insulating medium substrate 10 after notching in the x direction is about 28-32 mm, and the minimum dimension is about 20-25 mm.
(c) And filling a metal cylinder 11 with the same shape and size as the groove in the second groove to ensure that the metal cylinder 11 just fills the second groove, and the outer surface of the metal cylinder 11 and the left surface of the right insulating medium substrate 10 are on the same plane.
(4) The relative dielectric constants of the left insulating dielectric substrate 7 and the right insulating dielectric substrate 10 are made equal and are epsilon r According to the input electromagnetic pulse source, "the shape and size of the first groove contained in the left dielectric substrate structure", d y1 、d z1 、L z1 Dimension of the second groove contained in the right dielectric substrate structure, d y2 、d z2 And L z2 After scanning optimization calculation, the relative dielectric constant epsilon of the left side insulating medium substrate and the right side insulating medium substrate is calculated r And performing scanning optimization calculation, and combining the relative dielectric constant of the medium existing in practice to obtain the optimal solution of the increase of the internal field intensity of the large nonmetal effector.
According to the scanning optimization calculation, a first rectangular parallelepiped groove can be carved on the left surface of the left side insulating medium substrate 7, the sizes of the carved first groove in the x direction, the y direction and the z direction are respectively 10mm, 30mm and 35mm, and d can be taken y1 =d z1 =45mm,L z1 95 mm; the cylindrical bottom radius of the second groove of the cylindrical shape engraved on the left surface of the right insulating dielectric substrate 10 may be taken as 20mm, the dimension of the second groove in the x direction may be taken as 10mm, and d may be taken y2 =d z2 =45mm,L z2 90 mm. On the basis, when the left side insulating dielectric substrate 7 and the right side insulating dielectric substrateThe relative dielectric constants of the substrates 10 are equal and are all epsilon r When changing ε r The ratios of the field peaks at A, B, C and D, which are obtained in the yoz plane, to the case of the dielectric-free substrate structure (i.e., without the use of the present invention) are shown in Table 1.
TABLE 1
Figure GDA0003683605280000101
When the relative dielectric constants of the left side insulating dielectric substrate 7 and the right side insulating dielectric substrate 10 are equal and are epsilon r When changing ε r The ratios of the field peaks of the points a ', B', C 'and D' corresponding to the 4 points A, B, C and D, respectively, on the plane y-80 mm to the structure without a dielectric substrate (i.e., without the invention) are shown in table 2.
TABLE 2
Figure GDA0003683605280000111
According to tables 1 and 2, and considering that glycerin (glycerin) has a relative dielectric constant of 42.5 and a conductivity of 1X 10 - 8 S/m, optionally 42.5 is ε r The optimal solution of (a). In this case, the ratio of the peak value of the electric field at each measurement point in the large-sized non-metallic effect object 6 obtained by the present invention to the result obtained without the present invention is 1.52 to 2.07. In actual operation, glycerin can be filled and packaged in plastic molds with the same shape as the structure formed by forming the first groove on the left surface of the left insulating medium substrate 7 and the structure formed by forming the second groove on the left surface of the right insulating medium substrate 10, and then the metal strips 8 in the shape of a cuboid and the embedded metal cylinders 11 are respectively bonded on the two molds, so that the field intensity in the large-sized nonmetal effect 6 is enhanced, and the improvement of the irradiation cavity is completed.
In addition, when the irradiation cavity is improved by simply reducing the distance between the upper metal plate and the lower metal plate in the working space of the irradiation cavity in order to improve the internal field intensity of the large-sized non-metal effector in the irradiation cavity, the reduction of the distance between the upper metal plate and the lower metal plate in the working space is limited by the maximum height of the effector; when improvement is carried out by increasing the voltage peak value of the excitation source of the irradiation cavity, the design difficulty of a voltage source is increased; when the improvement is made by using the ' insulating dielectric block and insulating dielectric sleeve with specific insulating dielectric parameters and specific dimensions ' in the irradiation cavity ' proposed by cheng chang et al, the height of the insulating dielectric block is limited by the maximum height of the effector. Therefore, the feasibility of the invention in engineering implementation is better than the two conventional irradiation cavity improvement means to a certain extent and is also better than the irradiation cavity improvement mode proposed by Chengchang et al. The present invention has been described in sufficient detail to enable those skilled in the art to practice the invention, and it is to be understood that the detailed description of the invention is not limited to the specific embodiments shown and described. Any modification based on the idea of the invention falls within the scope of the right of the invention in the framework of the claims.

Claims (10)

1. An irradiation cavity based on a medium substrate structure for enhancing the internal field intensity of a large effector comprises an upper metal plate (2) and a lower metal plate (3) which are parallel to each other, and is characterized in that:
defining a space which is positioned between the upper metal plate (2) and the lower metal plate (3) and positioned inside the irradiation cavity as a working space of the irradiation cavity;
defining the horizontal direction from an excitation source of an irradiation cavity to a working space of the irradiation cavity as a length direction, namely a + x direction, the relative direction of an upper metal plate (2) and a lower metal plate (3) as a height direction, namely a +/-z direction, and the direction vertical to both the length direction and the height direction as a width direction, namely a +/-y direction; defining one side of the effector, which is close to the excitation source in the length direction, as the left side of the effector, and the corresponding side far away from the excitation source as the right side of the effector;
the insulating substrate comprises a left insulating medium substrate (7) and a right insulating medium substrate (10);
the left side insulating medium substrate (7) is an insulating medium flat plate which is placed in the working space of the irradiation cavity, is orthogonal to the upper metal plate (2) and the lower metal plate (3) and is positioned on the left side of the effector;
setting the area of z >0 above the height center in the irradiation cavity working space as an upper working space and the area of z <0 below as a lower working space;
defining the surface of the left side insulating medium substrate (7) facing to the side of the excitation source as the left surface of the left side insulating medium substrate (7), and forming a plurality of first grooves in the shape of cuboids or cubes on the left surface; wherein, a part of the first grooves are uniformly distributed on the upper half part of the left insulating medium substrate (7) with z >0, namely the first grooves are positioned in the upper working space; the other part of the first grooves are uniformly distributed on the lower half part of the left insulating medium substrate (7) with z <0, namely the lower working space;
an upper wall surface in the first groove, which is parallel to the upper metal plate (2) and the lower metal plate (3), is set as a groove top, and a lower wall surface is set as a groove bottom;
cuboid-shaped metal strips (8) are respectively adhered to the top of the first groove in the upper working space and the bottom of the first groove in the lower working space; the length direction size and the width direction size of the metal strip (8) in the shape of a cuboid are respectively equal to the length direction size and the width direction size of the first groove, and the height direction size is smaller than the height direction size of the first groove;
the right side insulating medium substrate (10) is an insulating medium flat plate which is arranged in the working space of the irradiation cavity, is orthogonal to the upper metal plate (2) and the lower metal plate (3) and is positioned on the right side of the effector;
defining the surface of one side, facing the excitation source, of the right side insulating medium substrate (10) as the left surface of the right side insulating medium substrate (10), and forming a plurality of second cylindrical grooves on the left surface; wherein, a part of the second grooves are uniformly distributed on the upper half part of the right insulating medium substrate (10) with z >0, namely the upper working space; the other part of the second grooves are uniformly distributed on the lower half part of the right insulating medium substrate (10) with z <0, namely, the second grooves are positioned in the lower working space;
and a metal cylinder (11) with the same shape and size as the second groove is filled in the second groove.
2. The irradiation cavity based on the medium substrate structure for enhancing the internal field strength of the large effector as claimed in claim 1, wherein: the width direction size of the left side insulating medium substrate (7) is the same as the widths of the upper metal plate (2) and the lower metal plate (3), and the height direction size is the same as the distance between the upper metal plate (2) and the lower metal plate (3);
the width direction size of the right side insulating medium substrate (10) is the same as the width of the upper metal plate (2) and the lower metal plate (3), and the height direction size is the same as the distance between the upper metal plate (2) and the lower metal plate (3).
3. The irradiation cavity based on the medium substrate structure for enhancing the field intensity in the large effector as claimed in claim 2, wherein: the maximum dimension of the left side insulating medium substrate (7) after notching in the length direction is 20-22 mm, and the minimum dimension is 8-10 mm.
4. The irradiation cavity based on the medium substrate structure for enhancing the internal field strength of the large effector as claimed in claim 3, wherein: the maximum dimension of the right side insulating medium substrate (10) after notching in the length direction is 28-32 mm, and the minimum dimension is 20-25 mm.
5. The irradiation cavity based on the medium substrate structure for enhancing the internal field strength of the large effector as claimed in claim 4, wherein: the centers of the left insulating medium substrate (7) and the right insulating medium substrate (10) are both positioned on an x axis; the center of the effector in the z direction is placed on a connecting line of the centers of the insulating medium substrates on the left side and the right side as much as possible, namely on an x axis;
defining the surface of one side, facing the effector, of the left insulating medium substrate (7) as the right surface of the left insulating medium substrate (7), wherein the minimum x-direction distance between the right surface and the effector is 15-20 mm; the minimum x-direction distance between the left surface of the right side insulating medium substrate (10) and the effector is 15-20 mm.
6. The irradiation cavity based on the medium substrate structure for enhancing the internal field strength of the large effector as claimed in claim 5, wherein: the size of the metal strip (8) in the cuboid shape in the height direction is 3-5 mm.
7. The irradiation cavity based on the medium substrate structure for enhancing the field intensity in the large effector as claimed in claim 6, wherein: the first grooves and the second grooves are arranged in a two-dimensional array mode.
8. The irradiation cavity based on the medium substrate structure for enhancing the field intensity in the large effector as claimed in claim 7, wherein: defining the distance between the centers of the adjacent first grooves in the upper working space in the width direction and the height direction as d y1 And d z1 (ii) a The distance between the centers of the adjacent first grooves in the lower working space in the width direction and the height direction is also d y1 And d z1
The distance between the centers of two upper and lower rows of adjacent first grooves, which are symmetrical about the plane of z-0 and closest to the plane of z-0, in the z direction is defined as L z1
Then L is z1 ﹥d z1
Defining the distance between the centers of the adjacent second grooves in the upper working space in the width direction and the height direction as d y2 And d z2 (ii) a The distance between the centers of the adjacent second grooves in the lower working space in the width direction and the height direction is also d y2 And d z2
The distance between the centers of two adjacent upper and lower rows of second grooves, which are "symmetrical about the plane z-0 and closest to the plane z-0", in the z direction is defined as L z2
Then L is z2 ﹥d z2
9. The irradiation cavity based on the medium substrate structure for enhancing the internal field strength of the large effector as claimed in claim 8, wherein: defining a mixed structure of a first groove formed in the left surface of a left side insulating medium substrate (7) and a cuboid-shaped metal strip (8) attached in the first groove as a left side medium substrate structure; defining a mixed structure of forming a second groove on the left surface of the right insulating medium substrate (10) and filling a metal cylinder (11) in the second groove as a right medium substrate structure;
the left side insulating medium substrate (7) and the right side insulating medium substrate (10) have the same relative dielectric constant which is epsilon r The optimal solution of the method is composed of the shape and size of the first groove contained in the left dielectric substrate structure and d y1 、d z1 、L z1 Dimension of the second groove contained in the right dielectric substrate structure, d y2 、d z2 、L z2 And the input electromagnetic pulse source.
10. The irradiation cavity based on the medium substrate structure for enhancing the internal field strength of the large effector as claimed in claim 9, wherein: the structure formed by arranging the first groove on the left surface of the left insulating medium substrate (7) and the structure formed by arranging the second groove on the left surface of the right insulating medium substrate (10) are both formed by plastic molds with the same shape, and the interiors of the molds are filled with and encapsulated with glycerin; the metal strip (8) of cuboid shape is fixed in first recess through the mode that bonds, and metal cylinder (11) are inlayed and are inlayed in the second recess.
CN202110482220.2A 2021-04-30 2021-04-30 Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector Active CN113181556B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110482220.2A CN113181556B (en) 2021-04-30 2021-04-30 Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110482220.2A CN113181556B (en) 2021-04-30 2021-04-30 Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector

Publications (2)

Publication Number Publication Date
CN113181556A CN113181556A (en) 2021-07-30
CN113181556B true CN113181556B (en) 2022-09-23

Family

ID=76983295

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110482220.2A Active CN113181556B (en) 2021-04-30 2021-04-30 Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector

Country Status (1)

Country Link
CN (1) CN113181556B (en)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1755131A2 (en) * 2005-08-19 2007-02-21 Ngk Insulators, Ltd. Electron beam irradiating apparatus
CN101672784A (en) * 2009-10-22 2010-03-17 郑州大学 Surface-enhanced Raman scattering underlay of #-shaped nano electromagnetic super medium
CN103776682A (en) * 2014-02-18 2014-05-07 中国人民解放军军事医学科学院放射与辐射医学研究所 Microwave irradiation chamber, microwave irradiation system and microwave irradiation and real-time observation method
CN203688333U (en) * 2014-02-18 2014-07-02 中国人民解放军军事医学科学院放射与辐射医学研究所 Microwave irradiation cavity and microwave irradiation system
CN104324425A (en) * 2014-10-17 2015-02-04 中国科学院苏州生物医学工程技术研究所 Blood irradiation instrument
CN104900299A (en) * 2015-04-10 2015-09-09 西北核技术研究所 Polymer insulator with uniform hole distribution on surface and preparation method thereof
WO2015167213A1 (en) * 2014-04-30 2015-11-05 (주)아모레퍼시픽 Kit for lipolysis by means of light radiation
CN107645063A (en) * 2017-07-28 2018-01-30 东南大学 The effective exciting bank of antisymmetric mode based on artificial surface phasmon microcavity
CN109103601A (en) * 2018-08-10 2018-12-28 电子科技大学 A kind of dual polarization double mode electromagnetism vortex generator
CN109364377A (en) * 2018-09-27 2019-02-22 西北核技术研究所 It is a kind of to realize the device for irradiating intracavitary nonmetallic effector fields inside strong-focusing
CN109632456A (en) * 2018-12-13 2019-04-16 西北核技术研究所 The device of field strength overall situation enhancing inside a kind of medium-and-large-sized effector of irradiation chamber

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007214271A (en) * 2006-02-08 2007-08-23 Zycube:Kk Substrate bonding method and semiconductor device
CN101299901B (en) * 2008-06-05 2011-03-30 宁波超能科技股份有限公司 Irradiation accelerator gathering magnetic iron and method for preparing the same
EP3312660A1 (en) * 2016-10-21 2018-04-25 Thomson Licensing Device for forming at least one tilted focused beam in the near zone, from incident electromagnetic waves
CN208903966U (en) * 2018-10-19 2019-05-24 东莞中子科学中心 X-ray tube, irradiation chamber and X-ray source device

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1755131A2 (en) * 2005-08-19 2007-02-21 Ngk Insulators, Ltd. Electron beam irradiating apparatus
CN101672784A (en) * 2009-10-22 2010-03-17 郑州大学 Surface-enhanced Raman scattering underlay of #-shaped nano electromagnetic super medium
CN103776682A (en) * 2014-02-18 2014-05-07 中国人民解放军军事医学科学院放射与辐射医学研究所 Microwave irradiation chamber, microwave irradiation system and microwave irradiation and real-time observation method
CN203688333U (en) * 2014-02-18 2014-07-02 中国人民解放军军事医学科学院放射与辐射医学研究所 Microwave irradiation cavity and microwave irradiation system
WO2015167213A1 (en) * 2014-04-30 2015-11-05 (주)아모레퍼시픽 Kit for lipolysis by means of light radiation
CN104324425A (en) * 2014-10-17 2015-02-04 中国科学院苏州生物医学工程技术研究所 Blood irradiation instrument
CN104900299A (en) * 2015-04-10 2015-09-09 西北核技术研究所 Polymer insulator with uniform hole distribution on surface and preparation method thereof
CN107645063A (en) * 2017-07-28 2018-01-30 东南大学 The effective exciting bank of antisymmetric mode based on artificial surface phasmon microcavity
CN109103601A (en) * 2018-08-10 2018-12-28 电子科技大学 A kind of dual polarization double mode electromagnetism vortex generator
CN109364377A (en) * 2018-09-27 2019-02-22 西北核技术研究所 It is a kind of to realize the device for irradiating intracavitary nonmetallic effector fields inside strong-focusing
CN109632456A (en) * 2018-12-13 2019-04-16 西北核技术研究所 The device of field strength overall situation enhancing inside a kind of medium-and-large-sized effector of irradiation chamber

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
《A Full Digitizing Design of Measuring Systems in Diagnosing of High-intensity Pulsed Radiation Field》;X. Cheng;《IEEE Nuclear Science Symposuim & Medical Imaging Conference》;20110613;全文 *
《Simulation analysis and experimental comparison of radiation near-fields for 10 meter-high TEM antenna》;Zhu Xiangqin;《IEEE Xplore》;20150827;全文 *
微波脉冲与带缝非金属腔耦合的数值模拟研究;马飞等;《微波学报》;20091231(第06期);全文 *
高功率脉冲微波辐照大鼠体内场强的数值模拟;裴剑等;《山西大学学报(自然科学版)》;20110815(第03期);全文 *

Also Published As

Publication number Publication date
CN113181556A (en) 2021-07-30

Similar Documents

Publication Publication Date Title
Klemm et al. Experimental and clinical results of breast cancer detection using UWB microwave radar
EP2079524B1 (en) Symmetric and preferentially steered random arrays for ultrasound therapy
CN100574829C (en) A kind of high-strength focus supersonic therapeutic system of image documentation equipment guiding
Ebbini et al. A cylindrical-section ultrasound phased-array applicator for hyperthermia cancer therapy
JP4282198B2 (en) Particle beam irradiation equipment
WO2021208306A1 (en) System for predicting electrical pulse ablation area
Feng et al. Microwave‐induced thermoacoustic tomography: Reconstruction by synthetic aperture
Kamimura et al. Chirp-and random-based coded ultrasonic excitation for localized blood-brain barrier opening
CN113181556B (en) Irradiation cavity based on medium substrate structure and used for enhancing field intensity in large effector
Kim et al. Lesion generation through ribs using histotripsy therapy without aberration correction
Lu et al. Two-step aberration correction: application to transcranial histotripsy
Elahi et al. GPU accelerated confocal microwave imaging algorithms for breast cancer detection
CN109701162B (en) Construction method of local focusing device for internal field intensity of effect object in irradiation cavity
CN109632456B (en) Device for overall enhancement of internal field intensity of large effector in irradiation cavity
Qian et al. Uniform tissue lesion formation induced by high-intensity focused ultrasound along a spiral pathway
Pichardo et al. New design for an endoesophageal sector-based array for the treatment of atrial fibrillation: a parametric simulation study
KR20180110857A (en) Apparatus and method of high-intensity focused ultrasound scanning
CN104644219B (en) Power density imaging method based on acousto-electric effect
CN109364377B (en) Device for realizing internal field intensity focusing of nonmetal effector in irradiation cavity
CN103479369A (en) High-absorption biological light material micro phantom for mammary gland X-ray phase-contrast imaging
CN115753325B (en) Irradiation cavity capable of globally and uniformly increasing internal field intensity of large effector and avoiding breakdown
CN103118739A (en) Implant having three-dimensional shape for electrically stimulating a nerve structure
CN115753325A (en) Irradiation cavity for globally and uniformly enhancing internal field intensity of large effector and avoiding breakdown
Ji et al. The characterization of an ultrasound spherical phased array for the ablation of deep-seated tissue
Zubair et al. Simulation of a modified multielement random phased array for image guidance and therapy

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant