CN103479369A - High-absorption biological light material micro phantom for mammary gland X-ray phase-contrast imaging - Google Patents

High-absorption biological light material micro phantom for mammary gland X-ray phase-contrast imaging Download PDF

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CN103479369A
CN103479369A CN201310006789.7A CN201310006789A CN103479369A CN 103479369 A CN103479369 A CN 103479369A CN 201310006789 A CN201310006789 A CN 201310006789A CN 103479369 A CN103479369 A CN 103479369A
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micro
mammary gland
phantom
different
carrier
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CN201310006789.7A
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Chinese (zh)
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罗述谦
监悟帅
石宏理
张超
吴明树
李君�
董立男
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首都医科大学
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Abstract

The invention relates to a high-absorption biological light material micro phantom for mammary gland X-ray phase-contrast imaging and belongs to the technical field of biomedical engineering. The micro phantom comprises a carrier which is made of an acrylic plate. Micro pores which are different in distribution, size and depth are distributed in the carrier. The micro pores are divided into vertical and horizontal radial micro pores. The carrier is divided into a semi-quantitative efficacy verification area and a simulated lesion area. The size of the micro pores in the semi-quantitative efficacy verification area is the same but the depth is different, or the size is different but the depth is the same. Fishing line short bars at different grades are inserted into the micro pores in the vertical radial direction of the semi-quantitative efficacy verification area. Glass micro beads, calcium carbonate, aluminum oxide and polyvinyl chloride particles are used in the simulated lesion area to simulate mammary gland plaque-like calcification and silt-like micro-calcification. Cotton balls, fiber agglomerates and various organic matters are used to simulate benign and malignant masses with blurry edges and clear edges. Metal wires are used to simulate mammary gland lesion fiber mechanisms and the streak structures of a normal mammary gland. The high-absorption biological light material micro phantom for mammary gland X-ray phase-contrast imaging has the advantages that the semi-quantitative detection and efficacy verification of equipment parameters can be realized and the simulation of mammary gland lesions can be realized.

Description

低吸收生物轻材料乳腺X线相衬成像微型仿体 Low light absorbent materials of biological breast X-ray phase contrast imaging phantoms Micro

技术领域 FIELD

[0001] 本发明涉及生物医学工程技术领域,一种乳腺X线相衬成像专用微型仿体制作方法。 [0001] The present invention relates to the field of medical biotechnological engineering, X-ray phase contrast imaging mammary gland-specific micro-fabrication method phantom. 包括:使用有机玻璃或亚克力板制作载体;载体上布满分布、大小、深度不同的微孔;微孔分垂直和水平径向两种;载体分半定量效验区和模拟病变区;半定量效验区的微孔大小相同而深度不同或大小不同而深度相同;半定量区垂直径向上的微孔内插不同标号的钓线短棒;在模拟病变区用玻璃微珠、碳酸钙、三氧化二铝和聚氯乙烯颗粒模拟乳腺斑块样钙化和泥沙样微钙化,用棉团、纤维团和各种有机物模拟边缘模糊和边缘清楚的良恶性肿块,用金属细丝模拟乳腺病变纤维机构和正常乳腺的条索样结构。 Comprising: the use of organic glass or acrylic board production carrier; covered different distribution, size, depth of the microporous support; radially vertical and horizontal sub-micropores two kinds; carrier half quantitative efficacy and simulated lesion area; semi-quantitative efficacy pore size and the same region or different sizes and different depths of the same depth; micropores vertical interpolation semiquantitative radial regions of different numbers of fishing line stubs; analog lesion glass beads, calcium carbonate, ferric oxide aluminum and polyvinyl chloride grain simulation plaque calcification breast microcalcifications and sediment samples, benign and malignant tumor group cotton fibers and various organic groups and analog fuzzy edge clear edge, with a metal filament fiber means and analog breast lesions cord-like structures of the normal breast. 本发明实现了制作一种专门用于X线乳腺相衬成像的具有半定量分析和模拟病变功能的微型仿体。 The present invention implements a specialized for the production of X-ray phase contrast imaging of breast phantom having a micro semi-quantitative analysis and simulation functions lesions.

背景技术 Background technique

[0002] 医学影像用仿体常用于X线、CT、MRI成像装置参数的调试以及病变模拟.从功能上可以分为定量分析、半定量分析和病变模拟三种。 [0002] Medical imaging phantoms commonly used in X-ray, CT, MRI apparatus debugging and simulation parameters lesion imaged from the function can be divided into the quantitative analysis, semi-quantitative analysis and simulation of three kinds of lesions. 相衬成像是一种生物医学中的新兴领域,可以对细微结构成像。 Phase contrast imaging is an emerging field of bio-medicine, fine structure can be imaged. 国内相衬成像的机构主要是北京同步辐射装置(BSRF) 4W1A-X射线成像实验站和上海光源(SSRF)BL13W1X射线成像及生物医学应用光束线站等。 Domestic phase contrast imaging mechanism mainly Beijing Synchrotron Radiation (BSRF) 4W1A-X-ray imaging source and Shanghai Experimental Station (SSRF) BL13W1X ray imaging and biomedical applications beamlines like. 相衬成像穿透力弱以及其边缘强化作用适合于软组织成像。 Phase contrast imaging through weak and strengthen the role of its edges suitable for soft tissue imaging. 乳腺是软组织,且乳腺病变发病率高,因此乳腺相衬成像是相衬成像最重要的部分。 Breast tissue is soft, and the high incidence of breast disease, breast and therefore phase contrast imaging is the most important phase contrast imaging section. 相衬成像光斑仅数毫米,远较传统医学成像装置光斑小,需要专门设计相应的结构精巧的微型仿体。 Phase contrast imaging spot only a few millimeters, much higher than conventional medical imaging apparatus small spot requires specially designed compact micro structure corresponding phantom. 国内尚未见适合用于乳腺X线相衬成像的微型仿体。 Country has not been used for micro phantom breast X-ray phase contrast imaging. 国外文献类似仿体未在国内销售,价格昂贵,缺少半定量分析,对病变模拟不充分,仅适用于国外专门的相衬成像装置。 Similar foreign literature phantom domestic sales is not expensive, lack of semi-quantitative analysis, simulation insufficient lesion, foreign specialized only for phase contrast imaging apparatus. 本发明涉及的仿体简单实用,能满足科学实验的基本要求,有效的解决了上述问题。 Imitating the present invention is simple and practical, to meet the requirements of basic science experiments, effective solution to the above problems.

发明内容 SUMMARY

[0003] 本发明要解决的技术问题在于:提供一种应用于生物医学工程技术领域,乳腺X线相衬成像专用微型仿体, 对设备参数进行半定量分析,对乳腺病变进行仿真。 [0003] The present invention is to solve that technical problem: to provide a technical field used in biomedical engineering, X-ray phase contrast imaging of breast-specific micro-phantom, device parameters for semi-quantitative analysis, simulation of breast lesions. 最为一种标准器材,支持相衬成像方面的科学研究。 The most a standard equipment, supporting scientific research phase contrast imaging.

[0004] 为解决上述技术问题,本发明采用以下技术方案: [0004] To solve the above problems, the present invention employs the following technical solution:

[0005] 使用有机玻璃或亚克力板制作载体,呈立方形;载体上布满分布、大小、深度不同的微孔;微孔分垂直和水平径向两种;载体分半定量效验区和模拟病变区;半定量效验区的微孔大小相同而深度不同或大小不同而深度相同;半定量区垂直径向上的微孔内插不同标号的钓线短棒;在模拟病变区用玻璃微珠、碳酸钙、三氧化二铝和聚氯乙烯颗粒模拟乳腺斑块样钙化和泥沙样微钙化,用棉团、纤维团和各种有机物模拟边缘模糊和边缘清楚的良恶性肿块,用金属细丝模拟乳腺病变纤维机构和正常乳腺的条索样结构。 [0005] using acrylic or plexiglass plate production carrier, cuboid; covered different distribution, size, depth of the microporous support; radially vertical and horizontal sub-micropores two kinds; carrier half quantitative efficacy and simulated lesion area region; the same pore size semi-quantitative efficacy and different depths or regions of different sizes and the same depth; micropores vertical interpolation semiquantitative radial regions of different numbers of fishing line stubs; glass beads in simulated lesion carbonate calcium, aluminum oxide, and polyvinyl chloride grain simulation breast plaque calcification and sediment samples microcalcifications, cotton group, groups and various organic fibers analog fuzzy edge and benign and malignant tumors clear edge, with a metal filament analog Article breast lesions and normal breast fiber bodies of cord-like structures.

[0006] 作为本发明的进一步改进: [0006] As a further development of the present invention:

[0007] 所述载体使用接近软组织密度的弱吸收材料。 The [0007] vector using the proximity feeble tissue density absorbent material. 可以使用有机玻璃或亚克力板。 Plexiglass or acrylic plate may be used. 载体大小2.5 X 2cm,厚度1cm。 Vector size 2.5 X 2cm, thickness 1cm. [0008] 所述载体上布满分布、大小、深度不同的微孔。 [0008] The full different distribution, size, depth of the microporous carrier. 微孔均呈圆形,直径0.6,0.8、1.0、 Microporous showed round, diameter 0.6,0.8,1.0,

1.2、4.0mm 四种。 1.2,4.0mm four.

[0009] 所述微孔分垂直和水平径向两种。 Radial two kinds of [0009] the vertical and horizontal sub-micropores. 其中垂直方向上有10个微管,直径Imm,深度5mm。 There vertically microtubules 10, Imm, a diameter, a depth of 5mm. 其内放置高质量钓线短棒3条。 Fishing line is placed within a high-quality three stubs. 钓线号数0.4、0.5、0.6、0.7、0.8、1.0、1.5、2.0、2.5、 No. 0.4,0.5,0.6,0.7,0.8,1.0,1.5,2.0,2.5 the line number,

3.0。 3.0. 直径分别0.104mm、0.117mm、0.128mm、0.138mm、0.148mm、0.165mm、0.205mm、0.235mm、().260mm、0.285mm。 Diameters 0.104mm, 0.117mm, 0.128mm, 0.138mm, 0.148mm, 0.165mm, 0.205mm, 0.235mm, (). 260mm, 0.285mm.

[0010] 所述载体分半定量效验区和模拟病变区。 [0010] The carrier half quantitative efficacy and simulated lesion area. 半定量效验区共16个孔,分四行。 Semi-quantitative efficacy region a total of 16 holes, on four lines. 每行4个孔。 4 wells per row. 孔径分别为0.6、0.8、1.0、1.2mm。 Pore ​​sizes 0.6,0.8,1.0,1.2mm. 相同孔径微孔深度分别为2、5、7、9mm。 Microporous pore same depths, respectively 2,5,7,9mm. 其内不填充任何材料。 Which without any filler material. 模拟病变区共14个直径4.0mm微孔,孔深度10mm。 Simulated lesion area of ​​14 micropores 4.0mm diameter, hole depth 10mm. 其内填充各种仿体材料。 An inner filler material of various phantoms.

[0011] 所述在模拟病变材料有玻璃微珠、碳酸钙、三氧化二铝和聚氯乙烯颗粒,用于模拟乳腺斑块样钙化和泥沙样微钙化。 [0011] The glass beads, calcium carbonate, aluminum oxide particles and polyvinyl chloride materials simulated lesion, plaque calcification for simulating the breast and muddy microcalcifications. 棉团、纤维团和各种有机物,用于模拟边缘模糊和边缘清楚的良恶性肿块。 Cotton group, groups and various organic fibers, edge blurring, and benign and malignant tumors clear edge for simulation. 金属细丝,用于模拟乳腺病变纤维机构和正常乳腺的条索样结构。 Metal filament, cord-like fiber structure breast lesions and normal breast mechanism for simulating. 各种材料搭配模拟各种病变形态。 A variety of materials with a variety of simulated lesions form. 总共搭配形式14种。 With a total of 14 kinds of forms.

[0012] 所述仿体用于模拟乳腺组织X线相衬成像平片摄影。 [0012] The breast tissue phantom for simulating the phase-contrast imaging X-ray photography flat sheet.

[0013] 与现有技术相比,本发明的优点在于:国内尚未见与本发明仿体相似的适合用于乳腺X线相衬成像的微型仿体。 [0013] Compared with the prior art, advantages of the present invention is that: the phantom domestic not suitable for the present invention is similar to a micro phantom of breast X-ray phase contrast imaging. 本发明涉及的仿体简单实用,有半定量分析,对病变模拟充分。 Imitating the present invention is simple and practical, with a semi-quantitative analysis, the lesion sufficiently simulated. 适用于X线相衬成像装置(系统),能满足科学实验的基本要求,有效的解决了上述问题。 Suitable for X-ray phase-contrast imaging apparatus (system), to meet the requirements of basic science experiments, effective solution to the above problems.

附图说明 BRIEF DESCRIPTION

[0014] 图1是仿体I型设计图 [0014] FIG. 1 is a phantom design type I

[0015] 图2是仿体I型实物图 [0015] FIG. 2 is a physical map phantom type I

[0016] 图3是仿体I型相衬图 [0016] FIG. 3 is a Type I phase contrast phantom in FIG.

[0017] 图4是仿体11型设计图 [0017] FIG 4 is a phantom 11 design of FIG.

[0018] 图5是仿体II型实物图 [0018] FIG. 5 is a pictorial diagram of phantom type II

[0019] 图6是仿体11型相衬图 [0019] FIG. 6 is a phase contrast phantom in FIG. 11 type

[0020] 图7是仿体111型设计图 [0020] FIG. 7 is a phantom 111 design of FIG.

[0021] 图8是仿体III型实物图 [0021] FIG. 8 is a physical map phantom type III

[0022] 图9是仿体111型相衬图 [0022] FIG. 9 is a type 111 phase contrast phantom in FIG.

Claims (6)

1.本发明涉及X线生物医学工程技术领域,一种乳腺相衬成像专用微型仿体制作方法: 1.使用有机玻璃或亚克力板制作载体。 1. The present invention relates to the field of medical X-ray engineering biotechnology, mammary gland-specific micro-phase contrast imaging phantoms production methods: 1. Preparation of Carrier plexiglass or acrylic plate.
2.载体上布满分布、大小、深度不同的微孔;微孔分垂直和水平径向两种。 Covered with a different distribution, size and depth of the micropores 2. The carrier; radially vertical and horizontal sub-micropores two kinds.
3.载体分半定量效验区和模拟病变区。 3. The carrier half quantitative efficacy and simulated lesion area.
4.半定量效验区的微孔大小相同而深度不同或大小不同而深度相同。 4. The same pore size semi-quantitative efficacy of different regions and the same in depth or different depths.
5.半定量区垂直径向上的微孔内插不同标号的钓线短棒。 Vertical interpolation micropores regions of different radial numeral 5. semiquantitative fishing line stubs.
6.在模拟病变区用玻璃微珠、碳酸钙、三氧化二铝和聚氯乙烯颗粒模拟乳腺斑块样钙化和泥沙样微钙化,用棉团、纤维团和各种有机物模拟边缘模糊和边缘清楚的良恶性肿块,用金属细丝模拟乳腺病变纤维机构和正常乳腺的条索样结构。 6. In the simulated lesion area glass beads, calcium carbonate, aluminum oxide, and polyvinyl chloride grain simulation breast plaque calcification and sediment samples microcalcifications, cotton group, groups and various organic fibers analog fuzzy edge and benign and malignant clear edge, means fibers simulated breast lesions and normal breast with a metal filament cord-like structure.
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CN106847037A (en) * 2017-04-05 2017-06-13 吉林大学 A kind of body mould and its preparation for mammary gland Microcalcification clinical training
CN107110795A (en) * 2014-12-23 2017-08-29 赛峰集团 It is intended for use in the imitative body in the quality control of faultage image
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