CN113171429A - Gastrodia elata tablets and preparation method thereof - Google Patents
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- CN113171429A CN113171429A CN202110399188.1A CN202110399188A CN113171429A CN 113171429 A CN113171429 A CN 113171429A CN 202110399188 A CN202110399188 A CN 202110399188A CN 113171429 A CN113171429 A CN 113171429A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention belongs to the technical field of traditional Chinese medicine processing, and discloses a rhizoma gastrodiae chewable tablet and a preparation method thereof. Adding 5 parts of rhizoma gastrodiae into 100 parts of purified water, decocting, taking the decoction, mixing the decoction with 3 parts of white granulated sugar to serve as an adhesive, mixing the adhesive with rhizoma gastrodiae powder to prepare a soft material, tabletting, and drying to obtain the rhizoma gastrodiae chewable tablets. The preparation method of the rhizoma gastrodiae chewable tablet comprises the following steps: decocting 5 parts of rhizoma Gastrodiae with 100 parts of purified water to obtain decoction, adding 3 parts of white sugar as binder, pulverizing rhizoma Gastrodiae, and sieving; weighing the adhesive according to a proportion, mixing, preparing a soft material and granulating; sieving the wet granules with a 14-mesh sieve, and drying for later use; and (3) installing and adjusting a tablet press, adding the granules into a blanking hopper after the empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, and tabletting and forming to obtain the gastrodia elata chewable tablets. The rhizoma gastrodiae chewable tablet is complete in tablet shape and free of fragments and splinters; the tablet is perfect in shape, uniform in size, and has special taste and smell, and slightly sweet taste.
Description
Technical Field
The invention belongs to the technical field of processing of traditional Chinese medicine decoction pieces, and particularly relates to a gastrodia elata chewable tablet and a preparation method thereof.
Background
At present, the gastrodia elata is a dry tuber of an orchidaceae plant, has the functions of calming the liver, calming the wind, relieving spasm and the like, is used for treating headache, dizziness, numbness of limbs, infantile convulsion, epilepsy, tetanic syndrome, and the like, and along with the improvement of the living standard of people, the medicinal health-care function of the gastrodia elata is more and more emphasized by people, and from the aspects of single medicinal development to health care, beverage, diet and the like, the processing technology of the gastrodia elata is also greatly improved, and the traditional preparation technology of gastrodia elata products cannot meet the market requirements.
Through the above analysis, the problems and defects of the prior art are as follows: the rhizoma gastrodiae tablet prepared by the prior art is the original rhizoma gastrodiae slice, is constrained by the original rhizoma gastrodiae shape, is irregular and incomplete, has cracked edges and is uneven in size.
The difficulty in solving the above problems and defects is: the basic components of the rhizoma gastrodiae tablet are not changed, other medicines or chemical products are not added as auxiliary materials, and the rhizoma gastrodiae tablet can be stored for a long time after being formed.
The significance of solving the problems and the defects is as follows: the rhizoma gastrodiae chewable tablet is prepared from rhizoma gastrodiae as a main raw material, and a small part of white granulated sugar as an adhesive auxiliary material and a taste enhancer. Solves the problems of inconvenient eating and difficult carrying of the existing rhizoma gastrodiae tablet products, and contains other components except rhizoma gastrodiae.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a rhizoma gastrodiae chewable tablet and a preparation method thereof.
The gastrodia elata chewable tablet is prepared from 97 parts of gastrodia elata and 3 parts of white granulated sugar according to the mass fraction, namely 100kg of gastrodia elata chewable tablet is prepared from 97kg of gastrodia elata and 3kg of white granulated sugar.
The invention also aims to provide a preparation method of the gastrodia elata chewable tablet, which comprises the following steps: adding 100 mesh rhizoma Gastrodiae powder into rhizoma Gastrodiae water decoction and white sugar, granulating by wet method, drying, and tabletting.
Further, the preparation method of the rhizoma gastrodiae chewable tablet comprises the following steps:
step one, weighing 5 parts of gastrodia elata according to a proportion, adding 100 parts of purified water, decocting, mixing with white granulated sugar to prepare an adhesive for later use, crushing the gastrodia elata, and sieving; weighing the adhesive in proportion, preparing a soft material and granulating;
step two, passing the wet granules through a 14-mesh sieve, and drying for 1 hour at 60 ℃ for later use;
and step three, installing and adjusting the tablet press, adding the granules into a blanking hopper after the empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, and tabletting and forming to obtain the rhizoma gastrodiae tablets.
Further, in step one, the screening comprises: sieving with 100 mesh sieve.
Further, in the step one, the weighing the adhesive in proportion comprises: according to the weight percentage of the gastrodia tuber powder: binder 10: 3 ratio of the binder.
Further, the concentration of the white granulated sugar serving as the binding agent is 3 percent.
Further, in the third step, the tabletting pressure is 14N.
By combining all the technical schemes, the invention has the advantages and positive effects that: the rhizoma gastrodiae chewable tablet prepared by the method has the advantages of complete tablet shape, glossy surface, uniform color and no fragment and splinter. The gastrodia elata chewable tablet is complete in tablet shape and uniform in size, contains the gastrodia elata as an effective component, and has unique taste and smell, and is slightly sweet.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without creative efforts.
Fig. 1 is a flow chart of a method for preparing gastrodia elata tablets in an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Aiming at the problems in the prior art, the invention provides a gastrodia elata tablet and a preparation method thereof, and the invention is described in detail with reference to the accompanying drawings.
The rhizoma gastrodiae chewable tablet provided by the embodiment of the invention consists of rhizoma gastrodiae and an adhesive according to mass fraction.
The preparation method of the rhizoma gastrodiae chewable tablet provided by the embodiment of the invention comprises the following steps: adding 10% adhesive into 100 mesh rhizoma Gastrodiae powder, granulating by wet method, drying, and tabletting.
As shown in fig. 1, the preparation method of the rhizoma gastrodiae chewable tablet provided by the embodiment of the invention comprises the following steps:
s101, crushing and sieving gastrodia elata; weighing the adhesive in proportion, preparing a soft material and granulating;
s102, passing the wet granules through a 14-mesh sieve, and drying at 60 ℃ for 1 hour for later use;
s103, installing and adjusting a tablet press, adding the granules into a blanking hopper after an empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, and tabletting and forming to obtain the gastrodia elata chewable tablets.
In step S101, the screening provided in the embodiment of the present invention includes: sieving with 100 mesh sieve.
In step S101, the weighing of the adhesive in proportion provided by the embodiment of the present invention includes: according to the weight percentage of the gastrodia tuber powder: binder 10: 3 ratio of the binder.
The concentration of the white granulated sugar serving as the binding agent provided by the embodiment of the invention is 10%.
In step S103, the tabletting pressure provided by the embodiment of the present invention is 14N.
The technical effects of the present invention will be further described with reference to specific embodiments.
Example 1:
firstly, preparing materials:
1. gastrodia elata powder (80 meshes)
2. Gastrodia elata powder (100 meshes)
3. Coarse powder of gastrodia tuber
4. Starch
5. White granulated sugar
6. Purified water
Second, predetermined scheme
1. Scheme (1): direct tabletting of 80-mesh rhizoma Gastrodiae powder
And (3) detection: and (3) installing and adjusting a tablet press, adding powder into a blanking hopper after an empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, and performing tablet forming, wherein tablets are fluffy and do not meet the quality standard of the tablets, and then adjusting the pressurizer to different pressures of 5N, 10N, 13N, 15N and the like respectively to form the tablets, which are fluffy and crisp and do not meet the quality requirement.
2. Scheme (2): direct tabletting of 100-mesh rhizoma Gastrodiae powder
And (3) detection: and (3) installing and adjusting the tablet press, adding the powder into a blanking hopper after the empty machine runs without errors, starting the tablet press, adjusting the pressurizer and the counter, so that the tablet press is not formed and does not accord with the quality standard of the tablet, and adjusting the pressurizer to different pressures of 5N, 10N, 13N, 15N and the like respectively, so that the tablet press is not formed and does not accord with the quality requirement.
3. Scheme (3): wet granulating 80 mesh rhizoma Gastrodiae powder with 10% starch slurry, drying, and tabletting
And (3) detection: and (3) installing and adjusting the tablet press, adding the granules into a blanking hopper after an empty machine runs without errors, starting the tablet press, adjusting the pressurizer and the counter, tabletting and forming, wherein the tablets are rough, brittle and cracked, and do not meet the quality standard of the tablets, and then adjusting the pressurizer to different pressures of 5N, 10N, 13N, 15N and the like, and tabletting and forming, but the tablets are still rough, brittle and cracked, and do not meet the quality requirement.
4. Scheme (4): granulating and drying 100-mesh rhizoma Gastrodiae powder with purified water, and tabletting
And (3) detection: installing and adjusting a tablet press, adding granules into a discharging hopper after an empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a meter, performing tablet forming, wherein the tablet is complete in shape but has a rough surface, powder is easy to fall off, and then adjusting the pressurizer to different pressures of 5N, 10N, 13N, 14N, 15N and the like respectively, performing tablet forming, wherein the surface is rough similarly, the pressure is adjusted to be 14N optimal, 15N is slightly heavy, the equipment load is large, and the sound is abnormal.
5. Scheme (5): wet granulating and drying 100 mesh rhizoma Gastrodiae powder with 10% starch slurry, and tabletting
And (3) detection: and (3) installing and adjusting a tablet press, adding the granules into a feeding hopper after an empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, adjusting the pressure to 14N, tabletting to form a complete tablet, and adjusting the pressurizer to 5N, 10N, 13N, 14N, 15N and other different pressures respectively without segment fragment cracking, wherein the effect is the best when the 14N is used.
6. Scheme (6): mixing 80 mesh rhizoma Gastrodiae powder with 10% water decoction of rhizoma Gastrodiae and white sugar, granulating by wet method, drying, and tabletting
And (3) detection: and (3) installing and adjusting a tablet press, adding the granules into a feeding hopper after an empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, adjusting the pressure to 14N, tabletting to form a complete tablet, wherein the surface is rough and uniform in color and luster, but cracked edges occur, and adjusting the pressurizer to 5N, 10N, 13N, 14N, 15N and other different pressures respectively, wherein the 14N is the best effect, and the cracked edges also occur.
7. Scheme (7): mixing 100 mesh rhizoma Gastrodiae powder with 10% water decoction of rhizoma Gastrodiae and white sugar, granulating by wet method, drying, and tabletting
And (3) detection: and (3) installing and adjusting a tablet press, adding the granules into a feeding hopper after an empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, adjusting the pressure to 14N, tabletting to form a complete tablet, and adjusting the pressurizer to 5N, 10N, 13N, 14N, 15N and other different pressures respectively without segment fragment cracking, wherein the effect is the best when the 14N is used.
III, main production equipment
1. Groove-shaped mixing machine
2. Oscillating granulator
3. Hot air circulation oven
4. Rotary tablet press
Four, auxiliary equipment
1. Electronic platform scale
2. 1% electronic balance
Fifth, testing equipment (without microorganism detection)
1. High performance liquid phase tester
2. Moisture determination
3. Sample separating sieve
4. Ultraviolet spectrophotometer
The above description is only for the purpose of illustrating the present invention and the appended claims are not to be construed as limiting the scope of the invention, which is intended to cover all modifications, equivalents and improvements that are within the spirit and scope of the invention as defined by the appended claims.
Claims (7)
1. The rhizoma gastrodiae chewable tablet is characterized by comprising 97 parts of rhizoma gastrodiae and 3 parts of white granulated sugar in parts by mass.
2. A method for preparing rhizoma gastrodiae chewable tablets according to claim 1, wherein the method for preparing the rhizoma gastrodiae chewable tablets comprises the following steps:
and adding 5 parts of gastrodia elata into 100 parts of purified water, decocting to obtain a water decoction, taking 3 parts of white granulated sugar as an adhesive, carrying out wet granulation on the water decoction and the white granulated sugar with gastrodia elata powder, drying, and tabletting to obtain the gastrodia elata chewable tablets.
3. The method for preparing rhizoma gastrodiae chewable tablets according to claim 2, wherein the method for preparing the rhizoma gastrodiae chewable tablets comprises the following steps:
step one, adding 100 parts of purified water into 5 parts of gastrodia elata, decocting, taking water decoction, mixing with 3 parts of white granulated sugar to prepare an adhesive, mixing with gastrodia elata powder, preparing soft materials, and granulating;
step two, passing the wet granules through a 14-mesh sieve, and drying for 1 hour at 60 ℃ for later use;
and step three, installing and adjusting a tablet press, adding the granules into a blanking hopper after the empty machine runs without errors, starting the tablet press, adjusting a pressurizer and a counter, and tabletting and forming to obtain the gastrodia elata chewable tablets.
4. The process for preparing chewable gastrodia tuber tablets according to claim 3, wherein in the first step, said sieving comprises: sieving with 100 mesh sieve.
5. The method of claim 3, wherein the step one, the step of weighing the binder in proportion comprises: according to the weight percentage of the gastrodia tuber powder: binder 10: 3 ratio of the binder.
6. The method for preparing rhizoma Gastrodiae chewable tablet of claim 2, wherein the binder white sugar concentration is 3%.
7. The method for preparing rhizoma Gastrodiae tablet as claimed in claim 2, wherein in step three, the tabletting pressure is 14N.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110399188.1A CN113171429A (en) | 2021-04-14 | 2021-04-14 | Gastrodia elata tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110399188.1A CN113171429A (en) | 2021-04-14 | 2021-04-14 | Gastrodia elata tablets and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN113171429A true CN113171429A (en) | 2021-07-27 |
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| CN202110399188.1A Pending CN113171429A (en) | 2021-04-14 | 2021-04-14 | Gastrodia elata tablets and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554256A (en) * | 2022-09-23 | 2023-01-03 | 乐泰药业有限公司 | Preparation method and quality control method of gastrodin tablets |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229325A (en) * | 2008-02-18 | 2008-07-30 | 北京阜康仁生物制药科技有限公司 | Rhizoma gastrodiae chewable tablet and preparing method thereof |
| CN101810325A (en) * | 2009-02-25 | 2010-08-25 | 北京利乐生制药科技有限公司 | Rhizoma gastrodiae chewable tablet and preparation method thereof |
| CN108126116A (en) * | 2016-12-01 | 2018-06-08 | 林凡友 | A kind of preparation process of full rhizoma gastrodiae tablet |
-
2021
- 2021-04-14 CN CN202110399188.1A patent/CN113171429A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229325A (en) * | 2008-02-18 | 2008-07-30 | 北京阜康仁生物制药科技有限公司 | Rhizoma gastrodiae chewable tablet and preparing method thereof |
| CN101810325A (en) * | 2009-02-25 | 2010-08-25 | 北京利乐生制药科技有限公司 | Rhizoma gastrodiae chewable tablet and preparation method thereof |
| CN108126116A (en) * | 2016-12-01 | 2018-06-08 | 林凡友 | A kind of preparation process of full rhizoma gastrodiae tablet |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554256A (en) * | 2022-09-23 | 2023-01-03 | 乐泰药业有限公司 | Preparation method and quality control method of gastrodin tablets |
| CN115554256B (en) * | 2022-09-23 | 2024-04-02 | 乐泰药业有限公司 | Preparation method and quality control method of gastrodin tablet |
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Application publication date: 20210727 |