CN113171191A - Method and device for promoting osseointegration of dental implant - Google Patents
Method and device for promoting osseointegration of dental implant Download PDFInfo
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- CN113171191A CN113171191A CN202110334290.3A CN202110334290A CN113171191A CN 113171191 A CN113171191 A CN 113171191A CN 202110334290 A CN202110334290 A CN 202110334290A CN 113171191 A CN113171191 A CN 113171191A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0089—Implanting tools or instruments
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Abstract
The invention discloses a method and a device for promoting osseointegration of a dental implant. The device comprises a hand-held mechanical vibrator and an antimicrobial application device; the handheld mechanical vibrator comprises a fixing device fixed on the implant healing base station, a vibration wave generating device and a handle used for controlling the fixing state of the fixing device; the vibration wave generating device is arranged on the fixing device and transmits vibration stimulation to the implant, and the antibacterial agent applying device is arranged on the fixing device and is used for directly applying the antibacterial agent containing nano silver to the surface of the implant. The invention promotes the osseointegration of the implant by mechanical vibration and the application of the nano-silver antibacterial agent, and can achieve better effect.
Description
Technical Field
The invention belongs to the field of oral implantation surgery, and particularly relates to a method and a device for promoting osseointegration of a dental implant by combining vibration waves with nano silver.
Background
Oral implantation is an emerging therapeutic technique in recent years. Implants are increasingly used clinically for the repair of defective or missing dentition by virtue of their functional utility, aesthetic appearance and independence of the individual. Osseointegration refers to the intimate, direct, resulting and functional contact of the implant surface with surrounding well-developed bone tissue without the intervening fibrous connective tissue. Tight osseointegration is critical for successful implant. However, for patients with systemic diseases (such as osteoporosis, etc.), the decrease of bone quality of bone cortex and the change of bone trabecular structure seriously affect the stability and integration power of bone implant, and are relative contraindications to oral implantation. In addition, bacterial contamination after implant implantation is another factor that hinders the success of the implant. Various bacteria exist in human oral cavity, and after the planting operation, the implant abutment exposed in the oral cavity has poor cleaning state due to improper cleaning mode or bad oral hygiene and other problems, dental plaque appears, inflammation is caused, and the implant is easy to loosen and fall off to cause the planting failure. Therefore, there is a need for a post-operative care device that promotes osseointegration of the implant and reduces the risk of bacterial infection.
Mechanical micro-stimulation is a short-term, simple, noninvasive and few-adverse-reaction physical therapy, and has been widely applied to clinical treatment of bone diseases and joint diseases due to safe and efficient bone induction and bone reconstruction effects. In recent years, many studies have been reported on the promotion of implant osseointegration by vibration stimulation. Low-amplitude high-frequency vibration waves (LMHFV) refer to mechanical microstimulation that can cause microstrain (less than or equal to 10 mu epsilon) or acceleration (less than or equal to 0.56g) of stressed tissues and has vibration frequency of 10-100 Hz. It has effects of improving alveolar bone quality, promoting implant osseointegration, and shortening rehabilitation time. .
The nano silver is silver particles with the particle size of 1-100 nm, is a novel antibacterial product based on a nanotechnology, and has the functions of broad-spectrum antibiosis, strong sterilization, strong permeability, restoration and regeneration, lasting antibiosis and the like. With the development of nanotechnology, the nano silver is continuously researched and applied. A large number of clinical studies show that nano-silver as an antibacterial agent with a strong bactericidal effect on microorganisms can overcome the drug resistance of bacteria compared with the traditional antibiotics, and the main bactericidal mechanism is as follows: (1) to receive O2Acting synergistically with protons to release Ag+，Ag+Complexing with nutrients in a bacterial environment system, reducing the concentration of elements essential for bacterial growth, and influencing the living environment of bacteria, thereby exerting bacteriostatic activity. (2) The DNA of the bacteria is concentrated in the nuclear area and is in a tense state, the double helix structure cannot be untied, and the replication capacity is lost. (3) It can chemically interact with cell wall and cell membrane to cause it to lose normal function. (4) The activity of dehydrogenase in the respiratory chain of bacteria is reduced to inhibit the respiration of bacteria, so that the bacteria can not obtain energy for maintaining normal life activity. In recent years, a great deal of research has been conducted on various means such as implant materials, surface coatings, drug use, etc., in order to promote osseointegration of implants. However, these methods have the disadvantages of complicated manufacturing process, poor biocompatibility, poor treatment effect, possible bacterial infection, difficult popularization and application, and the like. Especially bisphosphonates in medical therapy, have the potential to cause systemic osteonecrosis. Compared with the technologies, the invention has the advantages of simplicity, safety, high efficiency, antibiosis and strong inclusion, and can achieve ideal treatment effect.
Disclosure of Invention
The present invention is directed to a method and apparatus for promoting osseointegration of a dental implant. Aiming at the existing problems mentioned in the background technology, the invention promotes osseointegration by transmitting low-amplitude high-frequency vibration to the implant, and adds nano-silver antibacterial liquid for diminishing inflammation and resisting bacteria, thereby achieving the purpose of promoting the accelerated recovery after the implantation.
In order to achieve the purpose, the invention adopts the following technical scheme:
according to one aspect of the present invention, there is provided a method of promoting osseointegration of a dental implant: the method is that after the dental implant is implanted, the implant is mechanically stimulated by adopting vibration waves, and meanwhile, an antibacterial agent containing nano silver is applied to the surface of the implant.
Furthermore, the antibacterial agent containing nano silver is an antibacterial agent with silver content of more than 100ppm, central particle size of 2-3 nm, particle size distribution of less than 90% of 20nm, and purity of no more than three thousandth of silver content of other substances except silver and water.
Further, while the implant is mechanically stimulated by adopting vibration waves, the antibacterial agent containing the nano-silver is applied in a small amount for multiple times, and the application amount is as follows: the nanosilver-containing antimicrobial agent was diluted to a concentration of 5ppm and 50ml in a single application.
The micro-strain of the implant and its surroundings can be induced by using vibration waves, in particular low amplitude high frequency vibration waves (LMHFV), with a parameter of amplitude 8 μm and a frequency in the range of 70-100Hz, and can be: (1) the expression of osteogenic genes is influenced, the proliferation and differentiation of osteoblasts are stimulated, the bone density is improved, and the formation and healing of bone tissues are promoted; (2) regulating bone differentiation lineage, promoting cell differentiation to mesenchymal stem cell and hematopoietic stem cell, coordinating function and behavior of mesenchymal stem cell, further promoting alveolar bone tissue reconstruction, improving bone trabecular structure morphology, and improving bone strength; (3) improving local microcirculation of alveolar bone, increasing blood perfusion in bone, and promoting growth and metabolism of bone tissue, thereby increasing bone density; (4) promoting peri-implant bone healing, soft tissue repair and angiogenesis, and controlling inflammatory response and traumatic bone resorption. Especially, the implant and the periphery thereof are subjected to inflammation diminishing and antibiosis by adopting the specific antibacterial agent containing nano silver while the mechanical vibration is carried out, and the silver particles have strong effects of diminishing inflammation and promoting wound healing: the mechanical vibration stimulates the combination of the metal protease and sulfur radicals in the metalloprotease in the wound, so that the activity of the metalloprotease is reduced, the expression of microbial genes is reduced, and the functions of inhibiting bacteria, killing bacteria and preventing bacterial adhesion are achieved, thereby promoting the wound healing, promoting the adhesion and growth of osteoblasts and the expression of osteogenic genes, and promoting the formation of new bones. Achieving higher quality implant osseointegration.
According to another aspect of the present invention, there is provided an apparatus for promoting osseointegration of a dental implant, comprising a hand-held mechanical vibrator and an antimicrobial application device:
the handheld mechanical vibrator comprises a fixing device fixed on the implant healing base station, a vibration wave generating device and a handle used for controlling the fixing state of the fixing device; the vibration wave generating device is arranged on the fixing device and transmits vibration stimulation to the implant, and the antibacterial agent applying device is arranged on the fixing device and is used for directly applying the antibacterial agent containing nano silver to the surface of the implant.
Furthermore, fixing device include casing, two parallel arrangement's splint, first gear, first worm, wherein first splint are fixed in on the casing, first worm passes through the bearing and is connected with the second splint, first gear, first worm constitute worm gear drive mechanism, first gear rotation drives the second splint through first worm and is close to or keep away from first splint to regulation and control first, second splint interval. First splint, second splint adopt the silica gel material.
Furthermore, the handle comprises a cylindrical hollow shell, a second gear, a second worm and a sliding rod, wherein the second gear, the second worm and the sliding rod are arranged in the cylindrical hollow shell, the hollow shell is provided with an adjusting window, the second gear is arranged in the adjusting window, the second gear and the second worm form a worm and gear transmission mechanism, the second worm is a hollow rod body, one end of the sliding rod penetrates into the second worm, the sliding rod and the second worm are matched and can only move axially relative to each other but cannot rotate circumferentially relative to each other, and the other end of the sliding rod is fixed with the first gear.
Furthermore, the vibration wave generating device comprises a vibration head arranged at the bottom of the fixing device. The vibration amplitude of the vibration head is 8 mu m, and the frequency is 70-100 Hz.
Compared with the prior art, the invention has the advantages and innovations that:
firstly, low-amplitude high-frequency vibration waves are used as a mechanical stimulation form which is short-term, simple, convenient, noninvasive and less in adverse reaction, and can be transmitted to the periphery of the oral implant through the device, so that safe and efficient bone induction and bone reconstruction are realized, and osseointegration of the implant is promoted, and the field has the vacancy of the market of oral instruments;
the nano silver particles have the advantages of strong antibacterial property, wide antibacterial spectrum and small side effect, and can resist inflammation and bacteria, reduce infection, prevent peri-implantitis and reduce the failure rate of the planting;
the mechanical vibration and the antibacterial agent containing nano silver are combined, so that the osseointegration and tissue rehabilitation after the implantation can be effectively promoted, the period of oral implantation treatment is shortened, the efficiency is improved, the bone mass of jawbone is improved, the implantation success rate is improved, and the effect of 1+1 & gt 2 is realized;
the invention skillfully utilizes the worm gear transmission mechanism, the parallel splint and the like to arrange a brand new device, can operate on a single tooth implanted in the oral cavity, and meets the requirement of a patient with a single tooth missing;
the product adopts food-grade silica gel sheets to fix the implant base station, is safe and harmless, improves the comfort of patients relative to metal fixation, has strong practicability, conforms to the normal oral anatomical physiological structure, is convenient to disinfect or replace, and ensures the use safety of different patients.
Drawings
The present invention will be further understood and appreciated by reference to the following detailed description taken in conjunction with the accompanying drawings, which illustrate, by way of example, the principles of the invention and in which:
FIG. 1 is a schematic view of the overall structure of the apparatus of the present invention;
FIG. 2 is a schematic view of a fixing device according to the present invention;
FIG. 3 is a schematic view of the internal worm gear of the present invention;
FIG. 4 is a schematic view of the bearing component structure of the present invention;
in the figure: 1. holding the mechanical vibrator; 2. a fixing device; 3. an antimicrobial application device; 4. a second gear; 5. a second worm; 6. a slide bar; 7. a first gear; 8. a first worm; 9. a hose cover; 10. a second splint; 11. a first splint; 12. a second buckle; 13. a first buckle; 14. a bearing; 15. a wire; 16. a head is vibrated.
Detailed Description
The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings and specific embodiments:
the invention provides a method for promoting osseointegration of a dental implant, which comprises the following steps: the method is that after the dental implant is implanted, the implant is mechanically stimulated by adopting vibration waves, and meanwhile, an antibacterial agent containing nano silver is applied to the surface of the implant. The amplitude of the vibration wave is 8 μm, and the frequency is 70-100 Hz. The antibacterial agent containing nano silver is an antibacterial agent with silver content of more than 100ppm, central particle size of 2-3 nm, particle size distribution of 90% of below 20nm, and purity of no more than three thousandth of silver content except silver and water. While the implant is mechanically stimulated by adopting vibration waves, the antibacterial agent containing the nano-silver is applied in a small amount for multiple times, and the application amount is as follows: the nanosilver-containing antimicrobial agent was diluted to a concentration of 5ppm and 50ml in a single application. The antimicrobial agent may be applied every 30 minutes for 5 minutes during the mechanical stimulation.
As shown in FIG. 1, an example of an apparatus for promoting osseointegration of a dental implant comprises a hand-held mechanical vibrator 1 and an antibacterial agent applying device 3; the hand-held mechanical vibrator comprises a fixing device 2 fixed on the implant healing base station, a vibration wave generating device and a handle for controlling the fixing state of the fixing device; in this example, the vibration wave generating means comprises a vibration head 16 (only schematically shown in the figure, which may be downwardly convex) arranged on the fixture for transmitting vibration stimuli to the implant, connected to a controller via a lead 15, and emitting low-amplitude high-frequency vibration waves having an amplitude of 8 μm and a frequency of 70-100Hz, and the antimicrobial agent application means 3 arranged on the fixture 2 for directly applying the antimicrobial agent containing nano-silver to the surface of the implant.
As shown in fig. 2 and 4, the fixing device includes a housing, two parallel clamping plates, a first gear 7 and a first worm 8, wherein the first clamping plate 11 is fixed on the housing, the first worm 8 is connected with the second clamping plate 10 through a bearing 14, the first gear 7 and the first worm 8 form a worm gear transmission mechanism, and the first gear rotates to drive the second clamping plate to approach or depart from the first clamping plate through the first worm, so as to adjust and control the distance between the first clamping plate and the second clamping plate. First splint, second splint can adopt the silica gel material. The distance between the two silica gel clamping plates can be reduced by controlling to be adapted to the front and back diameters of the implant healing abutment of the tooth position to be treated, so that the device is fixed on the implant abutment;
as shown in fig. 1 and 3, the handle includes a cylindrical hollow shell, a second gear 4, a second worm 5, and a sliding rod 6, the hollow shell is provided with an adjusting window, the second gear 4 is installed in the adjusting window, the second gear 4 and the second worm 5 form a worm gear and worm transmission mechanism, the second worm 5 is a hollow rod, one end of the sliding rod 6 penetrates into the second worm 5, and the sliding rod and the second worm can only perform relative axial movement but cannot perform relative circumferential rotation, and the other end of the sliding rod 6 is fixed to the first gear 7. That is, when the operator dials the second gear 4, which drives the second worm 5 to rotate, the second worm 5 drives the sliding rod 6 to rotate together to drive the first gear 7, and the second worm 5 can slide on the sliding rod 6, and a hose cover 9 can be disposed on the sliding rod 6 to prevent the second worm 5 from hitting the housing.
In the invention, the used silica gel splint is food-grade silica gel, and is safe and harmless. And the silica gel splint is connected with the fixing device shell through the buckle, can be detached and is convenient to clean and replace. Generally, the disposable diaper is not recommended to be reused, and the safety and the sanitation are ensured. The antimicrobial application device may be manually controlled or may be electrically powered.
The using method of the device comprises the following steps:
an operator holds the handle part of the mechanical vibrator by hand and slides the second gear to ensure that the distance between the two silica gel clamping plates below the fixing device is slightly larger than the front and back diameters of the implant healing abutment at the required tooth position;
the handle part of the mechanical vibrator is held by hand, and after the two silica gel clamping plates are fixed on the implant healing base station at the required tooth positions, the vibration wave generating device and the antibacterial agent applying device are started. At the moment, the mechanical vibration wave stimulation is transmitted to the implant and the periphery of the implant, so that the implant and the periphery of the implant are subjected to micro-strain to promote safe and efficient bone induction and bone reconstruction; meanwhile, the nano-silver antibacterial agent is applied to the implant and the periphery of the implant so as to achieve the effects of resisting bacteria, diminishing inflammation, enhancing mechanical vibration and promoting osseointegration.
Claims (10)
1. A method for promoting the osseointegration of a dental implant is characterized in that after the dental implant is implanted, the implant is mechanically stimulated by vibration waves, and an antibacterial agent containing nano-silver is applied to the surface of the implant.
2. The method for promoting osseointegration of a dental implant according to claim 1, wherein the antibacterial agent containing nano-silver is an antibacterial agent having a silver content of 100ppm or more, a central particle size of 2 to 3nm, a particle size distribution of 90% or less of 20nm, and a purity of no more than three thousandths of the silver content, excluding silver and water.
3. The method for promoting osseointegration of a dental implant according to claim 1, characterized in that the antibacterial agent containing nanosilver is applied several times in small amounts, each time in amounts of: the nanosilver-containing antimicrobial agent was diluted to a concentration of 5ppm and 50ml in a single application.
4. The method for promoting osseointegration of a dental implant according to claim 1, wherein the vibration wave generating means has a vibration wave amplitude of 8 μm and a frequency of 70-100 Hz.
5. An apparatus for promoting osseointegration of a dental implant, comprising a hand-held mechanical vibrator and an antimicrobial application device; the handheld mechanical vibrator comprises a fixing device fixed on the implant healing base station, a vibration wave generating device and a handle used for controlling the fixing state of the fixing device; the vibration wave generating device is arranged on the fixing device and transmits vibration stimulation to the implant, and the antibacterial agent applying device is arranged on the fixing device and is used for directly applying the antibacterial agent containing nano silver to the surface of the implant.
6. The apparatus for promoting osseointegration of a dental implant according to claim 5, wherein the fixture comprises a housing, two parallel jaws, a first gear, a first worm, wherein the first jaw is fixed to the housing, the first worm is connected to the second jaw through a bearing, the first gear and the first worm form a worm gear transmission mechanism, and the first gear rotates to drive the second jaw to approach or separate from the first jaw through the first worm, thereby adjusting the distance between the first jaw and the second jaw.
7. The apparatus for promoting osseointegration of a dental implant according to claim 6, wherein the first and second splints are made of silicone.
8. The apparatus for promoting bone integration of a dental implant as claimed in claim 6, wherein the handle comprises a cylindrical hollow housing, a second gear, a second worm, and a sliding rod, the hollow housing has an adjustment window, the second gear is mounted in the adjustment window, the second gear and the second worm form a worm-gear transmission mechanism, the second worm is a hollow rod, one end of the sliding rod penetrates into the second worm and is engaged with the second worm for relative axial movement but not for relative circumferential rotation, and the other end of the sliding rod is fixed to the first gear.
9. The apparatus for promoting osseointegration of a dental implant according to claim 5, wherein the vibration wave generating means comprises a vibrating head disposed at the base of the fixture.
10. The apparatus for promoting osseointegration of a dental implant according to claim 5, wherein the vibration wave generating means has a vibration wave amplitude of 8 μm and a frequency of 70-100 Hz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110334290.3A CN113171191A (en) | 2021-03-29 | 2021-03-29 | Method and device for promoting osseointegration of dental implant |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110334290.3A CN113171191A (en) | 2021-03-29 | 2021-03-29 | Method and device for promoting osseointegration of dental implant |
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| CN113171191A true CN113171191A (en) | 2021-07-27 |
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| CN202110334290.3A Pending CN113171191A (en) | 2021-03-29 | 2021-03-29 | Method and device for promoting osseointegration of dental implant |
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| CN204658427U (en) * | 2015-05-30 | 2015-09-23 | 东莞理工学院 | A kind of manual cross bar clamping tool being convenient to clamping device |
| CN211953096U (en) * | 2020-04-28 | 2020-11-17 | 苏州元周律医疗科技有限公司 | Suction machine device |
| WO2021015406A1 (en) * | 2019-07-19 | 2021-01-28 | 전제이든형준 | Surgical kit for dental implant |
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2021
- 2021-03-29 CN CN202110334290.3A patent/CN113171191A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401586A (en) * | 2008-11-20 | 2009-04-08 | 苏伟 | Simple production method for nano-silver antiseptic solution |
| CN101708341A (en) * | 2009-12-11 | 2010-05-19 | 东华大学 | Method for preparing Ag-carrying bacterial cellulose hydrogel antimicrobial dressing and product thereof |
| CN102440265A (en) * | 2010-10-12 | 2012-05-09 | 珠海中金纳米科技有限公司 | Nanometer silver anti-mildew spray |
| CN101999412A (en) * | 2010-11-19 | 2011-04-06 | 佘振定 | Nano-silver solution and preparation method thereof |
| CN102579146A (en) * | 2012-03-02 | 2012-07-18 | 四川大学 | In vivo microvibration loading device for promoting dental implant-bone interface osteogenesis |
| CN204658427U (en) * | 2015-05-30 | 2015-09-23 | 东莞理工学院 | A kind of manual cross bar clamping tool being convenient to clamping device |
| WO2021015406A1 (en) * | 2019-07-19 | 2021-01-28 | 전제이든형준 | Surgical kit for dental implant |
| CN211953096U (en) * | 2020-04-28 | 2020-11-17 | 苏州元周律医疗科技有限公司 | Suction machine device |
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