CN113170894B - Preparation method of particle-type probiotics capable of being delivered by gastrointestinal tract - Google Patents
Preparation method of particle-type probiotics capable of being delivered by gastrointestinal tract Download PDFInfo
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- CN113170894B CN113170894B CN202110526260.2A CN202110526260A CN113170894B CN 113170894 B CN113170894 B CN 113170894B CN 202110526260 A CN202110526260 A CN 202110526260A CN 113170894 B CN113170894 B CN 113170894B
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Images
Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3409—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
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- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
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- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
- B01F35/1452—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids
- B01F35/1453—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids by means of jets of fluid, e.g. air
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01F35/22—Control or regulation
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110526260.2A CN113170894B (en) | 2021-05-14 | 2021-05-14 | Preparation method of particle-type probiotics capable of being delivered by gastrointestinal tract |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110526260.2A CN113170894B (en) | 2021-05-14 | 2021-05-14 | Preparation method of particle-type probiotics capable of being delivered by gastrointestinal tract |
Publications (2)
Publication Number | Publication Date |
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CN113170894A CN113170894A (en) | 2021-07-27 |
CN113170894B true CN113170894B (en) | 2022-08-09 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202110526260.2A Active CN113170894B (en) | 2021-05-14 | 2021-05-14 | Preparation method of particle-type probiotics capable of being delivered by gastrointestinal tract |
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Country | Link |
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CN (1) | CN113170894B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN116078213B (en) * | 2023-04-12 | 2023-06-30 | 河南心连心化学工业集团股份有限公司 | Prevent dust diffusion's mixer for fertilizer preparation |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10105347A1 (en) * | 2001-02-05 | 2002-08-22 | Nutrinova Gmbh | Sorbic acid preparation containing probiotics as a feed additive in livestock rearing |
CN103160489A (en) * | 2011-12-12 | 2013-06-19 | 润盈生物工程(上海)有限公司 | Preparation method and application of daily chemical microencapsulated probiotic |
EP3138409A1 (en) * | 2015-08-31 | 2017-03-08 | Zachodniopomorski Uniwersytet Technologiczny w Szczecinie | Method for production of a fermented goat's milk beverage |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN85104773A (en) * | 1985-06-20 | 1986-12-17 | 克莱克斯特拉尔 | Improve the method for moisture vegetables and meat raw material value and the nutrition product of producing by this method |
CN2076322U (en) * | 1990-11-24 | 1991-05-08 | 安陆市粮食局工业公司 | Multipurpose puffing machine for grain and oil |
CN207242751U (en) * | 2017-09-26 | 2018-04-17 | 浙江正和监理有限公司 | A kind of architectural engineering screw conveyor |
CN208786346U (en) * | 2018-08-02 | 2019-04-26 | 吉林标普生物科技有限公司 | A kind of probiotics prilling granulator |
CN209436251U (en) * | 2018-09-28 | 2019-09-27 | 菏泽睿智科技开发有限公司 | A kind of double-layer embedment equipment of beneficial bacteria of intestinal tract solid particle |
CN208963447U (en) * | 2018-10-31 | 2019-06-11 | 洛阳希望生物科技有限公司 | Microbiological feed production superfast loading device |
CN109566874A (en) * | 2018-12-03 | 2019-04-05 | 卢亮 | A kind of preparation method of enteric slow release type microelement particle |
CN109464425B (en) * | 2018-12-29 | 2021-02-05 | 上海交大昂立股份有限公司 | Probiotic embedded particle and preparation method thereof |
CN211431021U (en) * | 2019-11-05 | 2020-09-08 | 南京美森生物科技有限公司 | Double-screw puffing and extruding mechanism and device thereof |
CN211864910U (en) * | 2020-03-02 | 2020-11-06 | 云南康洲生物科技有限公司 | Screw extrusion granulator |
-
2021
- 2021-05-14 CN CN202110526260.2A patent/CN113170894B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10105347A1 (en) * | 2001-02-05 | 2002-08-22 | Nutrinova Gmbh | Sorbic acid preparation containing probiotics as a feed additive in livestock rearing |
CN103160489A (en) * | 2011-12-12 | 2013-06-19 | 润盈生物工程(上海)有限公司 | Preparation method and application of daily chemical microencapsulated probiotic |
EP3138409A1 (en) * | 2015-08-31 | 2017-03-08 | Zachodniopomorski Uniwersytet Technologiczny w Szczecinie | Method for production of a fermented goat's milk beverage |
Non-Patent Citations (2)
Title |
---|
Effects of Lactobacillus plantarum and Lactobacillus paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind,Placebo-Controlled Clinical Trial;Asa Hakansson et al.,;《nutrients》;20190816;第11卷;第1-12页 * |
Ussing chamber在肠道屏障功能研究中的进展;杨振等;《肠外与肠内营养》;20060731;第13卷(第4期);第233-236页 * |
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