CN113170894A - Device and method for preparing particle type probiotics capable of being delivered through gastrointestinal tract - Google Patents

Device and method for preparing particle type probiotics capable of being delivered through gastrointestinal tract Download PDF

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Publication number
CN113170894A
CN113170894A CN202110526260.2A CN202110526260A CN113170894A CN 113170894 A CN113170894 A CN 113170894A CN 202110526260 A CN202110526260 A CN 202110526260A CN 113170894 A CN113170894 A CN 113170894A
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section
coating
machine body
deliverable
probiotic
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CN202110526260.2A
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CN113170894B (en
Inventor
邹立强
马丽
刘伟
刘军平
高洪霞
成策
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Nanchang University
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Nanchang University
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3409—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/80—After-treatment of the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
    • B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/10—Maintenance of mixers
    • B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
    • B01F35/1452—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids
    • B01F35/1453—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids by means of jets of fluid, e.g. air
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2215—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/43—Supporting receptacles on frames or stands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium

Abstract

The invention discloses a particle type probiotic preparation device capable of being delivered by gastrointestinal tract, which relates to the field of probiotic food production, and comprises a double-screw extruder, a feeding and stirring device, an extruding device, a coating device, a cutting and discharging device and a control device, wherein the double-screw extruder comprises a machine body, a supporting device, a feeding and stirring device, an extruding device, a coating device, a cutting and discharging device and a control device; the charging and stirring device comprises a conical charging cavity, a charging hole, a stirring shaft and the like; the extruding device comprises a conveying auger, and a material moving cavity is formed around the conveying auger; the coating device comprises a die head, the die head is provided with a penetration hole, and the upper part of the coating section is provided with a coating liquid tank and a pressure pump; the cutting and discharging device comprises a cutting tool, and a material receiving platform is arranged below the cutting tool. The invention also discloses a preparation method of the particle type probiotics capable of being delivered by the gastrointestinal tract, which comprises the steps of liquefying grease, mixing other raw materials and processing into finished products. The invention can stir the raw materials, extrude and coat, automatically cut and discharge, flexibly adjust the size and shape of the finished product, and can realize large-scale production on a production line.

Description

Device and method for preparing particle type probiotics capable of being delivered through gastrointestinal tract
Technical Field
The invention relates to the field of probiotic food production, in particular to a device and a method for preparing granular probiotics capable of being delivered by gastrointestinal tract.
Background
In recent years, probiotics have a key role in human health, are widely applied to various products and are accepted by more and more people. The probiotic preparation is used for providing beneficial live bacteria for organisms and the internal environment of the organisms and improving the micro-ecological balance of human bodies.
At present, few probiotic granular products are produced, and probiotic powder is mainly produced; and the prior art in the preparation of gastrointestinal deliverable probiotic particles is mainly: the bacterial powder is directly used as a core material to carry out multilayer coating or extrusion granulation, fluidized bed spraying to realize coating and the like, most of the bacterial powder is used for realizing gastrointestinal tract delivery by changing the composition of coating liquid, and most of the prior art is not suitable for large-scale production in factories; moreover, the survival rate of the probiotics is low, and the probiotics can not be completely ensured to safely reach the gastrointestinal tract for colonization and play a role.
The invention patent with publication number CN109464425A discloses a probiotic embedded particle and a preparation method thereof, wherein the embedded particle comprises a probiotic core and three embedded layers outside the probiotic core, and the embedded layers sequentially comprise from inside to outside: a starch protective layer, a film coating isolation layer and an enteric coating layer. The survival rate of the live bacteria embedded by the scheme is 39-49%; the survival rate after accelerated storage for 2 months at 37 ℃ is 18-42%; the survival rate of the probiotics in the artificial gastric juice for 60min is 77-85%, the viable bacteria content of the probiotics in the shelf life can be obviously improved, and meanwhile, most of the probiotics can be released in the intestinal tract, so that the beneficial effect is exerted.
However, this invention does not disclose how the embedding is achieved and the procedure cannot be directly applied to large-scale production.
Disclosure of Invention
Based on the situation, the technical problem to be solved by the invention is to provide a particle type probiotic preparation device capable of being delivered by gastrointestinal tract, which is used for stirring raw materials, then carrying out extrusion forming and coating treatment, realizing gastrointestinal tract delivery of probiotic particles through multiple layers of coatings, then automatically cutting and discharging, flexibly adjusting the size and shape of a finished product, and realizing flow line large-scale production.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a device for preparing probiotic bacteria in granule form for gastrointestinal delivery comprises a twin-screw extruder.
Further, the double-screw extruder comprises a machine body, a supporting device, a feeding and stirring device, an extruding device, a coating device, a cutting and discharging device and a control device.
Further, the organism sets up in strutting arrangement top and divide into heating heat preservation section, cooling section, low temperature section and coating section, just the length of heating heat preservation section, cooling section and low temperature section shortens in proper order to this reduces the damage that the extrusion process caused probiotic, specifically, its length ratio is 3: 2: 1, the raw material put into the heating and heat preservation section is liquid, the liquid is changed into semi-fluid through the temperature reduction section, and the finished product is discharged through coating cutting after the low-temperature section is slowly solidified.
Further, reinforced agitating unit sets up in the heating heat preservation section in the organism, and it is including connecting in the toper type feeding chamber of organism top, just toper type feeding chamber is located the left end in the organism, toper type feeding chamber top intercommunication has the feed inlet, just the feed inlet leads to the organism outside, toper type feeding intracavity portion center is provided with the (mixing) shaft of connecting in the organism upper wall, the (mixing) shaft is by the motor drive who sets up in the organism top, just the (mixing) shaft is provided with a plurality of puddlers.
Preferably, the rotation speed of the stirring shaft is 100-200 rpm/min.
Optionally, the puddler equidistance symmetry sets up on the (mixing) shaft, and is provided with stirring branch on half puddler, is provided with on half puddler and refines the blade, and stirring through refining to the raw materials makes the probiotic neither deposit, also can not float, but suspend in the raw materials evenly.
Further, a transverse partition is arranged at the lower part of the conical feeding cavity and connected with a linear cylinder arranged on the left side outside the machine body;
preferably, the conical feed inlet top is provided with the scavenge pipe, the scavenge pipe leads to the organism outside, just a plurality of shower nozzles are installed to the scavenge pipe, the shower nozzle is located conical feeding intracavity portion.
Further, extrusion device including set up in two transport augers of organism lower part, carry the auger to be connected to the organism in the coating section and all separately by setting up in the outside left motor drive of organism, just be provided with helical blade on carrying the auger, helical blade's pitch is in divide into three specification and reduce in proper order on heating heat preservation section, cooling section and the low temperature section three-section, helical blade sets up all around and removes the chamber to the material, the material remove the chamber with toper type feeding chamber lower extreme intercommunication. And a gas inlet is arranged below the front end of the conveying auger, a gas pressure meter is arranged above the gas inlet, the gas inlet is communicated with a gas conveying pipe, and the tail end of the gas conveying pipe is communicated with an inert gas source.
Specifically, the ratio of the screw pitches of the helical blades on the heating and heat-preserving section, the cooling section and the low-temperature section is 1.5: 1.25: 0.8.
preferably, the ratio of the major diameter of the helical blade to the diameter of the screw of the conveying auger is 3: 2.
preferably, the gas delivery pipe is provided with an electromagnetic valve.
Furthermore, the heating and heat preservation section and the cooling section of the material moving cavity are respectively provided with a temperature adjusting pipe in a surrounding manner, the temperature adjusting pipes are internally provided with self-circulating water and are connected with a water temperature controller and a circulating water pump, a cooling device is arranged outside the material moving cavity of the low-temperature section part, and the cooling device comprises a compressor, a condenser, a drying filter and an evaporator.
Furthermore, the coating device is arranged in a coating section area of the machine body and comprises a plurality of die heads communicated with the material moving cavity, a plurality of permeation holes are formed in the die heads, and a coating liquid tank and a pressure pump are arranged on the upper portion of the coating section.
Specifically, the periphery of the die head is provided with a coating liquid cavity communicated with a coating liquid box, and the coating liquid continuously seeps out through a penetration hole on the die head.
Alternatively, the present invention may adjust the number of dies according to the number of coating layers desired.
Optionally, the coating solution is coated on the particles except for forming a film by gelatin; the coating liquid can be tightly attached to the solid product by crosslinking and electrostatic adsorption.
Further, the cutting and discharging device comprises a linear air cylinder arranged above the right side of the die head, a cutting tool is installed at the tail end of the linear air cylinder through a tool adapter plate, a material receiving table is arranged below the cutting and discharging device, the left side of the material receiving table is in butt joint with the die head, and a discharging conveyor belt installed on the supporting device is arranged below the material receiving table;
furthermore, the feeding and stirring device, the extruding device, the coating device, the cutting and discharging device, the motor, the air cylinder, the water temperature controller, the air pressure gauge, the electromagnetic valve, the circulating water pump and the cooling device are all connected with the control device.
Further, controlling means sets up in including controller, display screen, operating button and alarm lamp.
Further, the supporting device comprises a supporting platform and a plurality of supporting legs.
A method for preparing a gastrointestinal deliverable particle type probiotic bacteria, which is applied to the above-mentioned gastrointestinal deliverable particle type probiotic bacteria preparation device, comprising the steps of:
step 1, liquefying grease: mixing solid oil, beeswax, carnauba wax, gamma-oryzanol and beta-sitosterol according to the weight ratio of 70-80: 5-10: 3-5: 3-6: 2-4 to 70-80 ℃ to melt the mixture into liquid;
specifically, the solid oil comprises any one or a combination of at least two of palm oil, coconut oil and shortening.
Step 2, when the temperature is reduced to 40 +/-2 ℃, adding the mixture in a ratio of 20-30: 40-55: 15-25: 2-10 parts of probiotic bacteria powder, prebiotics, psyllium husk powder and self-crosslinking auxiliary materials, wherein the total amount of the probiotic bacteria powder, the prebiotics, the psyllium husk powder and the self-crosslinking auxiliary materials is 30-50% of the total amount of solid oil, beeswax, carnauba wax, gamma-oryzanol and beta-sitosterol; the grease can move in the material moving cavity and the final product can be molded.
In particular, the probiotic comprises any one of the genus bifidobacterium, lactobacillus or a combination of at least two thereof;
specifically, the prebiotics include any one of functional oligosaccharides (xylo-oligosaccharide, fructo-oligosaccharide, galacto-oligosaccharide, inulin, etc.), polysaccharides, protein hydrolysates, or a combination of at least two thereof;
specifically, the self-crosslinking auxiliary material comprises any one or combination of more of TG enzyme, laccase and calcium salt;
the coating liquid comprises any one or combination of more of gelatin, beet pectin and sodium alginate.
Optionally, the coating solution further comprises any one or a combination of two or more of carrageenan, guar gum and xanthan gum.
Specifically, gelatin can be crosslinked with TG enzyme, sodium alginate can be crosslinked with calcium salt, beet pectin can be crosslinked with laccase, etc.
Optionally, the scheme is not limited to the above crosslinking modes, and other composition crosslinking can be selected, so as to better protect the probiotics.
Step 3, mixingThe mixed raw materials are fed into the particle type probiotic preparation device capable of being delivered by gastrointestinal tract through a feed inlet, finished product particles after extrusion coating and cutting are discharged through a discharge conveyor belt, and the content of active probiotics in the finished product particles is more than or equal to 107CFU/g。
The invention has the beneficial effects that:
1. the helical blades on the conveying auger in the extruder are arranged into three sections, and the pitch is divided into three specifications which are sequentially reduced, so that the death rate of probiotics caused by extrusion is reduced;
2. the finished product particles are subjected to multilayer coating through the die heads arranged at the coating device, gastrointestinal tract delivery of the probiotic particles is better realized, high probiotic coating rate is realized, the survival rate of the gastrointestinal tract is improved, and the number of layers of the coating and the size and the shape of the finished product are adjustable by changing the number and the shape of the die heads;
3. an inert gas source is introduced to assist the conveying auger to convey the raw material forwards, and the oxidation of the grease can be effectively prevented;
4. the production device is simple to operate, is suitable for large-scale production and assembly line operation, and can effectively improve the production efficiency.
Drawings
The invention will be further described with reference to the accompanying drawings and specific embodiments,
FIG. 1 is a schematic front view of the internal structure of the present invention;
FIG. 2 is a schematic diagram of the conveying auger structure of the invention;
FIG. 3 is a schematic top view of the conveying auger structure of the present invention;
the parts in the figures correspond to the reference numerals:
1-body; 2-a support device; 3-a charging and stirring device; 4-an extrusion device; 5-coating device; 6-cutting and discharging device; 7-a control device; 21-a support platform; 22-a leg; 31-a tapered feed cavity; 32-a feed inlet; 33-a stirring shaft; 34-a stirring rod; 35-stirring support rod; 36-thinning blade; 37-transverse partition; 38 cleaning the tube; 39-a spray head; 41-conveying auger; 42-a material moving cavity; 43-water temperature controller; 44-a cooling device; 45 helical blades; 46-gas inlet; 47-gas delivery pipe; 48-inert gas source; 49-barometer; 51-a die head; 52-a permeate pore; 53-coating liquid tank; 54-a pressure pump; 61-a cutter adapter plate; 62-a cutting tool; 63-a receiving platform; 64-an outfeed conveyor; 71-a controller; 72-a display screen; 73-operating buttons; 74-warning light.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "above", "left", "lower", "right", "below", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the present invention, unless otherwise expressly stated or limited, the terms "disposed," "connected," and the like are to be construed broadly, e.g., "connected" can be either a fixed connection or an adjustable connection; may be a mechanical connection; may be directly connected. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Example 1
Referring to fig. 1-3, a gastrointestinal deliverable granular probiotic preparation device comprises a twin screw extruder.
The double-screw extruder comprises a machine body 1, a supporting device 2, a feeding and stirring device 3, an extruding device 4, a coating device 5, a cutting and discharging device 6 and a control device 7.
Specifically, organism 1 sets up in strutting arrangement 2 top and be divided into heating heat preservation section, cooling section, low temperature section and coating section, just the length of heating heat preservation section, cooling section and low temperature section shortens in proper order to this reduces the damage that whole extrusion process caused probiotic. The raw material put into the heating and heat preservation section is liquid, becomes semifluid through the cooling section, and the finished product is discharged after the coating is slowly solidified through the low-temperature section and is cut.
Wherein, reinforced agitating unit 3 sets up in the heating heat preservation section in organism 1, and it is including connecting in the toper type feeding chamber 31 of organism 1 top, and toper type feeding chamber 31 is located organism 1 inner left end, and toper type feeding chamber 31 top intercommunication has feed inlet 32, and feed inlet 32 leads to the organism 1 outside.
In order to suspend the probiotics in the raw material uniformly, a stirring shaft 33 is disposed in the center of the interior of the conical feeding cavity 31, the stirring shaft 33 is driven by a motor disposed above the machine body 1, and the stirring shaft 33 is provided with three pairs of stirring rods 34.
Preferably, the rotation speed of the stirring shaft 33 is 150 rpm/min.
Preferably, the stirring shaft 33 is connected with the upper wall of the machine body 1.
Preferably, the stirring rods 34 are symmetrically arranged on the stirring shaft 33 at equal intervals, and half of the stirring rods 34 are provided with the stirring struts 35, and half of the stirring rods 34 are provided with the thinning blades 36.
Wherein, the lower part of the conical feeding cavity 31 is provided with a transverse partition 37, and the transverse partition 37 is connected with a linear cylinder arranged on the left side outside the machine body 1;
preferably, in order to clean the inside of the machine body, a cleaning pipe 38 is arranged above the conical feed inlet 32, the cleaning pipe 38 is communicated with the outside of the machine body 1, 5 spray heads 39 are arranged on the cleaning pipe 38, and the spray heads 39 are positioned inside the conical feed cavity 31.
Wherein, the extrusion device 4 includes two conveying augers 41 arranged at the lower part of the machine body 1, the conveying augers 41 are connected to the inner coating section of the machine body 1 and are respectively driven by a motor arranged at the left side outside the machine body 1, and the conveying augers 41 are provided with helical blades 45, the death rate of probiotics caused by extrusion is effectively reduced, so that the thread pitch of the helical blades 45 is sequentially reduced on the heating and heat-preserving section, the cooling section and the low-temperature section, the periphery of the helical blades 45 is provided with a material moving cavity 42, the material moving cavity 42 is communicated with the lower end of the conical feeding cavity 31, and in order to prevent grease oxidation and assist the conveying augers to convey raw materials, a gas inlet 46 is arranged below the front end of the conveying augers, a barometer 49 is arranged above the gas inlet 46, the gas inlet 46 is communicated with a gas conveying pipe 47, and the tail end of the gas conveying pipe 47 is communicated with an inert gas source 48.
Preferably, the gas delivery pipe 47 is provided with an electromagnetic valve.
Wherein, the heating heat preservation section of material removal chamber 42, cooling section part are all surrounded respectively outward and are provided with the pipe that adjusts the temperature, and it is intraductal that to adjust the temperature is the self-circulating water, and all be connected with water temperature controller 43 and circulating water pump, and the material removal chamber 42 of low temperature section part is provided with cooling device 44 outward, and cooling device 44 includes compressor, condenser, drier-filter, evaporimeter.
Wherein, the coating device 5 is arranged in the coating section area of the machine body 1 and comprises two die heads 51 communicated with the material moving cavity 42, the die heads 51 are provided with permeation holes 52, and the upper part of the coating section is provided with a coating liquid tank 53 and a pressure pump 54.
The finished product particles are subjected to multilayer coating through the die head 51 arranged at the coating device 5, so that gastrointestinal tract delivery of probiotic particles is better realized, high probiotic encapsulation rate is realized, and the survival rate of the gastrointestinal tract is improved.
Alternatively, when the shape of the finished product needs to be adjusted, only the corresponding die 51 needs to be replaced.
The cutting and discharging device 6 comprises a linear cylinder arranged above the right side of the die head 51, the tail end of the linear cylinder is provided with a cutting tool 62 through a tool adapter plate 61, a material receiving table 63 is arranged below the cutting and discharging device 6, the left side of the material receiving table 63 is in butt joint with the die head 51, and a discharging conveyor belt 64 arranged on the supporting device 2 is arranged below the material receiving table 63;
wherein, the charging and stirring device 3, the extrusion device 4, the coating device 5, the cutting and discharging device 6, the motor, the cylinder, the water temperature controller 43, the circulating water pump, the air pressure gauge 49, the electromagnetic valve and the cooling device 44 are all connected with the control device 7.
Preferably, the control device 7 is provided to include a controller 71, a display 72, an operation button 73, and an alarm lamp 74.
The display screen 72 displays the operating status and parameters of the various structures of the device.
Wherein the support device 2 comprises a support platform 21 and four legs 22.
Example 2
Referring to fig. 1-3, a gastrointestinal deliverable granular probiotic preparation device comprises a twin screw extruder.
The double-screw extruder comprises a machine body 1, a supporting device 2, a feeding and stirring device 3, an extruding device 4, a coating device 5, a cutting and discharging device 6 and a control device 7.
Specifically, organism 1 sets up in strutting arrangement 2 top and be divided into heating heat preservation section, cooling section, low temperature section and coating section, just the length of heating heat preservation section, cooling section and low temperature section shortens in proper order to this reduces the damage that whole extrusion process caused probiotic. The length ratio is 3: 2: 1. the raw material put into the heating and heat preservation section is liquid, becomes semifluid through the cooling section, and the finished product is discharged after the coating is slowly solidified through the low-temperature section and is cut.
Wherein, reinforced agitating unit 3 sets up in the heating heat preservation section in organism 1, and it is including connecting in the toper type feeding chamber 31 of organism 1 top, and toper type feeding chamber 31 is located organism 1 inner left end, and toper type feeding chamber 31 top intercommunication has feed inlet 32, and feed inlet 32 leads to the organism 1 outside.
In order to suspend the probiotics in the raw material uniformly, a stirring shaft 33 is disposed in the center of the interior of the conical feeding cavity 31, the stirring shaft 33 is driven by a motor disposed above the machine body 1, and the stirring shaft 33 is provided with three pairs of stirring rods 34.
Preferably, the rotation speed of the stirring shaft 33 is 150 rpm/min.
Preferably, the stirring shaft 33 is connected with the upper wall of the machine body 1.
Preferably, the stirring rods 34 are symmetrically arranged on the stirring shaft 33 at equal intervals, and half of the stirring rods 34 are provided with the stirring struts 35, and half of the stirring rods 34 are provided with the thinning blades 36.
Wherein, the lower part of the conical feeding cavity 31 is provided with a transverse partition 37, and the transverse partition 37 is connected with a linear cylinder arranged on the left side outside the machine body 1;
preferably, in order to clean the inside of the machine body, a cleaning pipe 38 is arranged above the conical feed inlet 32, the cleaning pipe 38 is communicated with the outside of the machine body 1, 5 spray heads 39 are arranged on the cleaning pipe 38, and the spray heads 39 are positioned inside the conical feed cavity 31.
Wherein, the extrusion device 4 includes two conveying augers 41 arranged at the lower part of the machine body 1, the conveying augers 41 are connected to the inner coating section of the machine body 1 and are respectively driven by a motor arranged at the left side outside the machine body 1, and the conveying augers 41 are provided with helical blades 45, the death rate of probiotics caused by extrusion is effectively reduced, so that the thread pitch of the helical blades 45 is sequentially reduced on the heating and heat-preserving section, the cooling section and the low-temperature section, the periphery of the helical blades 45 is provided with a material moving cavity 42, the material moving cavity 42 is communicated with the lower end of the conical feeding cavity 31, and in order to prevent grease oxidation and assist the conveying augers to convey raw materials, a gas inlet 46 is arranged below the front end of the conveying augers, a barometer 49 is arranged above the gas inlet 46, the gas inlet 46 is communicated with a gas conveying pipe 47, and the tail end of the gas conveying pipe 47 is communicated with an inert gas source 48.
Preferably, the ratio of the screw pitches of the helical blades 45 on the three sections of the heating and holding section, the cooling section and the low-temperature section is 1.5: 1.25: 0.8.
preferably, the ratio of the major diameter of the helical blade 45 to the screw diameter of the conveying auger is 3: 2.
preferably, the gas delivery pipe 47 is provided with an electromagnetic valve.
Wherein, the heating heat preservation section of material removal chamber 42, cooling section part are all surrounded respectively outward and are provided with the pipe that adjusts the temperature, and it is intraductal that to adjust the temperature is the self-circulating water, and all be connected with water temperature controller 43 and circulating water pump, and the material removal chamber 42 of low temperature section part is provided with cooling device 44 outward, and cooling device 44 includes compressor, condenser, drier-filter, evaporimeter.
Wherein, the coating device 5 is arranged in the coating section area of the machine body 1 and comprises two die heads 51 communicated with the material moving cavity 42, the die heads 51 are provided with permeation holes 52, and the upper part of the coating section is provided with a coating liquid tank 53 and a pressure pump 54.
The finished product particles are subjected to multilayer coating through the die head 51 arranged at the coating device 5, so that gastrointestinal tract delivery of probiotic particles is better realized, high probiotic encapsulation rate is realized, and the survival rate of the gastrointestinal tract is improved.
Alternatively, when the shape of the finished product needs to be adjusted, only the corresponding die 51 needs to be replaced.
The cutting and discharging device 6 comprises a linear cylinder arranged above the right side of the die head 51, the tail end of the linear cylinder is provided with a cutting tool 62 through a tool adapter plate 61, a material receiving table 63 is arranged below the cutting and discharging device 6, the left side of the material receiving table 63 is in butt joint with the die head 51, and a discharging conveyor belt 64 arranged on the supporting device 2 is arranged below the material receiving table 63;
wherein, the charging and stirring device 3, the extrusion device 4, the coating device 5, the cutting and discharging device 6, the motor, the cylinder, the water temperature controller 43, the circulating water pump, the air pressure gauge 49, the electromagnetic valve and the cooling device 44 are all connected with the control device 7.
Preferably, the control device 7 is provided to include a controller 71, a display 72, an operation button 73, and an alarm lamp 74.
The display screen 72 displays the operating status and parameters of the various structures of the device.
Wherein the support device 2 comprises a support platform 21 and four legs 22.
Example 3
A method for preparing a gastrointestinal deliverable particle type probiotic bacteria, which is applied to the gastrointestinal deliverable particle type probiotic bacteria preparation device of example 1, comprises the following steps:
step 1, liquefying grease: mixing solid oil, beeswax, carnauba wax, gamma-oryzanol and beta-sitosterol according to a weight ratio of 78: 8: 4: 6: 4 weighing and dissolving into liquid at about 75 ℃;
specifically, the solid grease comprises the following components in percentage by weight of 2: 1 mixed palm oil and shortening;
step 2, when the temperature is reduced to 40 +/-2 ℃, adding the mixture in a ratio of 25: 48: 20: 7, uniformly mixing the probiotic bacteria powder, the prebiotics, the psyllium husk powder and the self-crosslinking auxiliary material;
specifically, the probiotic bacteria are selected from bifidobacteria;
specifically, the prebiotics comprise xylo-oligosaccharide, inulin, fructo-oligosaccharide and galacto-oligosaccharide, and the proportion is 3: 3: 2: 2.
and 3, feeding the mixed raw materials into the particle type probiotic preparation device capable of being delivered to the gastrointestinal tract, which is described in the embodiment 1, through a feeding hole 32, controlling the temperatures of a heat preservation area, a cooling area and a low temperature area to be 25 +/-2 ℃, 4 +/-2 ℃ and-10 +/-2 ℃, respectively, conveying the raw materials to a ground, extruding and forming, and simultaneously performing osmotic coating, wherein a die head 51 is arranged on the coating device 5 for performing single-layer coating, the flow rate of a coating liquid is 8mL/min, and cutting to obtain the probiotic particles capable of being delivered to the gastrointestinal tract. The prepared granular probiotic product still keeps the complete granular shape after being digested by the stomach, and the survival rate of the probiotic after being digested by the small intestine is 49.5 percent.
Specifically, the coating liquid comprises the following components in proportion of 40: 30: 25: 5, gelatin, sodium alginate, beet pectin and carrageenan, wherein the self-crosslinking auxiliary materials comprise 40 percent of: 35: 25 TG enzyme, calcium salt and laccase.
Example 4
A method for preparing a gastrointestinal deliverable particle type probiotic bacteria, which is applied to the gastrointestinal deliverable particle type probiotic bacteria preparation device of example 1, comprises the following steps:
step 1, liquefying grease: mixing solid oil, beeswax, carnauba wax, gamma-oryzanol and beta-sitosterol according to a weight ratio of 78: 8: 4: 6: 4 weighing and dissolving into liquid at about 75 ℃;
specifically, the solid grease comprises the following components in percentage by weight of 2: 1 mixed palm oil and shortening;
step 2, when the temperature is reduced to 40 +/-2 ℃, adding the mixture in a ratio of 25: 48: 20: 7, uniformly mixing the probiotic bacteria powder, the prebiotics, the psyllium husk powder and the self-crosslinking auxiliary material;
specifically, the probiotic bacteria are selected from bifidobacteria;
specifically, the prebiotics comprise xylo-oligosaccharide, inulin, fructo-oligosaccharide and galacto-oligosaccharide, and the proportion is 3: 3: 2: 2.
and 3, feeding the mixed raw materials into the particle type probiotic preparation device capable of being delivered to the gastrointestinal tract, which is described in the embodiment 1, through a feeding hole 32, controlling the temperatures of a heat preservation area, a cooling area and a low temperature area to be 25 +/-2 ℃, 4 +/-2 ℃ and-10 +/-2 ℃, respectively, conveying the raw materials to a ground, extruding and forming and simultaneously performing osmotic coating, wherein the coating device 5 is provided with two die heads 51 for performing double-layer coating, the flow rate of a coating liquid is 8mL/min, and cutting to obtain the probiotic particles capable of being delivered to the gastrointestinal tract. The prepared granular probiotic product still keeps the complete granular shape after being digested by the stomach, and the survival rate of the probiotic after being digested by the small intestine is 65.4 percent.
The coating liquid comprises the following components in percentage by weight: 30: 25: 5, gelatin, sodium alginate, beet pectin and carrageenan, wherein the self-crosslinking auxiliary materials comprise 40 percent of: 35: 25 TG enzyme, calcium salt and laccase.
Examples of the experiments
According to the present invention, applicants compared the cross-linked coating schemes of examples 3 and 4 with pure fungal powder and a conventional uncrosslinked coating scheme, which does not use a self-crosslinking adjuvant and has 1 coating layer, as compared to examples 3 and 4, and the comparison results are shown in table 1:
TABLE 1 comparison of results of control experiment
Figure BDA0003065933140000141
Figure BDA0003065933140000151
And (4) conclusion: compared with the control group in the embodiment 3, the cross-linking of sodium alginate and calcium salt, the cross-linking of gelatin and TG enzyme, and the cross-linking of beet pectin and laccase can greatly improve the survival rate of the probiotics of the prepared granular probiotic product after being digested by small intestines.
The comparison between the example 3 and the example 4 shows that the increase of the number of the coating liquid layers can effectively improve the survival rate of the probiotics of the prepared granular probiotic product after being digested by the small intestine.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims (10)

1. A gastrointestinal tract deliverable granule type probiotic preparation device, comprising a twin screw extruder, characterized in that:
the double-screw extruder comprises a machine body, a supporting device, a feeding and stirring device, an extruding device, a coating device, a cutting and discharging device and a control device;
the machine body is arranged above the supporting device, the inner space of the machine body is sequentially provided with a heating and heat-preserving section, a cooling section, a low-temperature section and a coating section, and the lengths of the heating and heat-preserving section, the cooling section and the low-temperature section are sequentially shortened;
the feeding and stirring device is arranged above a heating and heat-preserving section in the machine body and is communicated with the heating and heat-preserving section, and comprises a conical feeding cavity connected above the machine body, the conical feeding cavity is positioned at the left end of the heating and heat-preserving section, a feeding hole is communicated above the conical feeding cavity, a stirring shaft is arranged in the conical feeding cavity, the stirring shaft is driven by a motor I arranged above the machine body, and the stirring shaft is provided with a plurality of stirring rods; the lower part of the conical feeding cavity is provided with a transverse partition, and the transverse partition is connected with a linear cylinder arranged on the left side of the machine body;
the extruding device comprises two conveying augers arranged at the lower part in the machine body, the conveying augers are driven by a motor II arranged at the left side outside the machine body, spiral blades are arranged on the conveying augers, the screw pitches of the spiral blades are divided into three sections, namely a heating and heat-preserving section, a cooling section and a low-temperature section, and the three sections are sequentially reduced in specification, material moving cavities are arranged around the spiral blades, and the material moving cavities are communicated with the lower end of the conical feeding cavity; a gas inlet is arranged below the front end of the conveying auger, a gas pressure gauge is arranged above the gas inlet, the gas inlet is communicated with a gas conveying pipe, and the tail end of the gas conveying pipe is communicated with an inert gas source;
the material moving cavity is positioned in the heating and heat preservation section and the cooling section, the outer sides of the material moving cavity are all surrounded with temperature adjusting pipes, the temperature adjusting pipes are connected with a water temperature controller and a circulating water pump, the material moving cavity is positioned in the low temperature section, the outer sides of the material moving cavity are provided with a cooling device, and the cooling device comprises a compressor, a condenser, a drying filter and an evaporator;
the coating device is arranged in a coating section of the machine body and comprises a plurality of die heads communicated with the material moving cavity, a plurality of permeation holes are formed in the die heads, and a coating liquid tank and a pressure pump are arranged at the upper part of the coating section;
the cutting and discharging device comprises a linear air cylinder arranged above the right side of the die head, the tail end of the linear air cylinder is provided with a cutting tool through a tool adapter plate, a material receiving table is arranged below the cutting and discharging device, the left side of the material receiving table is in butt joint with the die head, and a discharging conveyor belt arranged on the supporting device is arranged below the material receiving table;
and the motor I, the motor II, the coating device, the cutting and discharging device, the motor, the air cylinder, the water temperature controller, the air pressure gauge, the circulating water pump and the cooling device are all connected with the control device.
2. A gastrointestinal deliverable particulate probiotic preparation device according to claim 1, wherein: the cleaning device is characterized in that a cleaning pipe is arranged above the conical feeding cavity and communicated to the outside of the machine body, a plurality of spray heads are installed on the cleaning pipe, and the spray heads are located inside the conical feeding cavity.
3. A gastrointestinal deliverable particulate probiotic preparation device according to claim 1, wherein: the stirring rods are symmetrically arranged on the stirring shaft at equal intervals, a stirring support rod is arranged on one half of the stirring rods, and a thinning blade is arranged on one half of the stirring rods.
4. A gastrointestinal deliverable particulate probiotic preparation device according to claim 1, wherein: the control device is arranged on the display screen and comprises a controller, a display screen, an operating button and an alarm lamp.
5. A method for preparing particle probiotics capable of being delivered by gastrointestinal tract is characterized in that: the method is applied to a gastrointestinal tract deliverable particle type probiotic preparation device according to claims 1-4, and comprises the following steps:
step 1, liquefying grease: mixing solid oil, beeswax, carnauba wax, gamma-oryzanol and beta-sitosterol according to the weight ratio of 70-80: 5-10: 3-5: 3-6: 2-4, heating to 70-80 ℃ to melt the mixture into liquid;
step 2, when the temperature is reduced to 40 +/-2 ℃, adding the mixture in a ratio of 20-30: 40-55: 15-25: 2-10 parts of probiotic bacteria powder, prebiotics, psyllium husk powder and self-crosslinking auxiliary materials, wherein the total amount of the probiotic bacteria powder, the prebiotics, the psyllium husk powder and the self-crosslinking auxiliary materials is 30-50% of the total amount of solid oil, beeswax, carnauba wax, gamma-oryzanol and beta-sitosterol;
step 3, feeding the mixed raw materials into the gastrointestinal tract deliverable particle type probiotic preparation device according to any one of claims 1 to 4 through a feeding hole, extruding, coating and cutting to obtain finished product particles, and discharging the finished product particles through a discharge conveyor belt, wherein the content of active probiotics in the finished product particles is more than or equal to 107CFU/g。
6. A method of preparing a gastrointestinal deliverable particulate probiotic bacteria according to claim 5, wherein: the solid oil comprises any one or combination of at least two of palm oil, coconut oil and shortening.
7. A method of preparing a gastrointestinal deliverable particulate probiotic bacteria according to claim 5, wherein: the self-crosslinking auxiliary material comprises any one or combination of more of TG enzyme, laccase and calcium salt.
8. The method for preparing a gastrointestinal deliverable particulate probiotic bacteria according to claim 7, wherein: the coating liquid comprises any one or combination of more of gelatin, beet pectin and sodium alginate.
9. A method of preparing a gastrointestinal deliverable particulate probiotic bacteria according to claim 5, wherein: the probiotic bacteria comprise one of the genus Bifidobacterium, Lactobacillus or a combination of at least two of the same.
10. A method of preparing a gastrointestinal deliverable particulate probiotic bacteria according to claim 5, wherein: the prebiotics comprise any one or combination of at least two of functional oligosaccharides, polysaccharides and protein hydrolysates.
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