CN113143983A - Process flow of freeze-dried traditional Chinese medicine pseudo-ginseng powder - Google Patents
Process flow of freeze-dried traditional Chinese medicine pseudo-ginseng powder Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to the technical field of frozen panax notoginseng, in particular to a process flow of freeze-dried traditional Chinese medicine panax notoginseng powder, which comprises the following steps; step one, selecting materials; step two, cutting; step three, sterilizing on line; step four, pulping and extracting juice; step five, drying the medicine cake; step six, crushing and sieving; seventhly, packaging and detecting, wherein the pseudo-ginseng is subjected to freeze-drying treatment while the quality and the nutritional ingredients of the pseudo-ginseng are ensured, so that the pseudo-ginseng is high in fidelity and is suitable for processing high value-added products such as chemical products, medicines, space food and the like; the structure is not changed, because the drying is carried out in a frozen state, the original structure is kept, and the concentration phenomenon cannot occur; the rehydration performance is good, the water is dissolved quickly and completely after being added, and the original properties are almost immediately recovered; the storage time is long, and the drying is carried out under vacuum, so that the moisture can be removed, and the dried product can be stored for a long time without deterioration and oxidation.
Description
Technical Field
The invention relates to the field of frozen panax notoginseng, in particular to a process flow of freeze-dried traditional Chinese medicine panax notoginseng powder.
Background
Pseudo-ginseng is one of precious medicinal materials, has a long history, and has remarkable curative effects of removing blood stasis, stopping bleeding, reducing swelling and relieving pain. To facilitate long term storage, the notoginseng is usually dried. However, the product obtained by traditional drying is generally reduced in volume and hardened in texture, so that some substances in the pseudo-ginseng are oxidized, most of volatile ingredients are lost, and some heat-sensitive substances, such as protein and vitamins, are denatured. The microorganism will lose activity, and the dried substance will not be dissolved in water easily, so the dried notoginseng product has great difference in properties compared with before drying, thereby affecting the medicinal value of notoginseng.
Disclosure of Invention
The invention aims to provide a process flow of freeze-dried traditional Chinese medicine pseudo-ginseng powder, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a process flow of freeze-dried traditional Chinese medicine pseudo-ginseng powder comprises the following steps:
selecting materials, selecting a good production place according to the production environment of the pseudo-ginseng, selecting the pseudo-ginseng, ensuring the integrity of raw materials and avoiding rotting, and cleaning the raw materials to avoid impurity residues;
cutting the pseudo-ginseng into slices according to the characteristics of the pseudo-ginseng, and cleaning and draining the pseudo-ginseng;
step three, online sterilization, namely putting the pseudo-ginseng into an ozone sterilization box, and sterilizing the pseudo-ginseng under different pressures by using different gases until the pseudo-ginseng reaches related specified indexes;
pulping to obtain juice, adding a proper amount of sterile water, crushing the pseudo-ginseng slices by using a high-speed universal crusher to obtain the juice, and pre-freezing the fresh juice in an ultra-low temperature freezer;
step five, drying the medicine cake, namely putting the pre-frozen fresh juice into a vacuum low-temperature drying oven, performing vacuum low-temperature drying on the juice, determining the optimal drying temperature and vacuum degree, performing resolution drying, slowly raising the temperature, keeping the temperature for a period of time, observing the pressure condition in the drying oven, and finishing freeze drying;
step six, crushing and sieving, crushing, determining the optimal crushing temperature, crushing and sieving until no residue exists;
and seventhly, packaging and detecting, namely, vacuum packaging is adopted, and meanwhile, microorganism detection is carried out.
Preferably, the first step adopts an HPLC technology to measure chemical components in the pseudo-ginseng, and distinguishes the pseudo-ginseng with different producing areas and different picking times to determine an accurate source.
Preferably, the steps are washed by flowing water once, and then the thin pseudo-ginseng slices are spread in a net-shaped tray and are stood in the natural environment for draining for 10-15 min.
Preferably, the third step is to examine three gases of gasified hydrogen peroxide, ozone and ethylene oxide, sterilize at different temperatures and pressures for different time, and check the sterilized decoction pieces for microorganisms to determine the optimal online sterilization time.
Preferably, the fourth step is adding a little sterile water according to the water content of the original medicine, pulping and filtering, filtering until the residue is lower than 2-3% of the original medicine, and pre-freezing at the high temperature, the medium temperature and the low temperature respectively, wherein the pre-freezing is the most complete and the shortest time is the optimal pre-freezing temperature.
Preferably, the step five is performed with vacuum low-temperature drying under the conditions of high vacuum degree, medium vacuum degree and low vacuum degree respectively, the optimal drying temperature and vacuum degree are determined, the temperature is raised after drying is completed, the condenser is closed, observation is performed for 30-60s, and if the pressure in the freeze drying box is not obviously raised, freeze drying is finished.
Preferably, in the sixth step, the high temperature, the medium temperature and the low temperature are selected for crushing, the crushing temperature which is convenient to crush and energy-saving and is the designated optimal crushing temperature is crushed for 2-10min, the crushed materials are sieved by a 100-mesh sieve, and the residues are crushed and sieved until no residues exist.
Compared with the prior art, the invention has the beneficial effects that: a large amount of moisture substances in the pseudo-ginseng are cooled and frozen into solid in advance through freeze drying, then water vapor is directly sublimated under the vacuum condition, and the substances are left in an ice shelf during freezing, so that the physical, chemical and biological denaturation of the dried substances is prevented to the greatest extent; the pseudo-ginseng has strong fidelity and is suitable for processing high value-added products such as chemical products, medicines, space food and the like; the structure is not changed, because the drying is carried out in a frozen state, the original structure is kept, and the concentration phenomenon cannot occur; the rehydration performance is good, the water is dissolved quickly and completely after being added, and the original properties are almost immediately recovered; the storage time is long, and the drying is carried out under vacuum, so that the moisture can be removed, and the dried product can be stored for a long time without deterioration and oxidation.
Drawings
FIG. 1 is a comparison of the freezing process and the conventional process.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, the present invention provides a technical solution: a process flow of freeze-dried traditional Chinese medicine pseudo-ginseng powder comprises the following steps:
selecting materials, selecting a good production place according to the production environment of the pseudo-ginseng, selecting the pseudo-ginseng, ensuring the integrity of raw materials and avoiding rotting, and cleaning the raw materials to avoid impurity residues;
cutting the pseudo-ginseng into slices according to the characteristics of the pseudo-ginseng, and cleaning and draining the pseudo-ginseng;
step three, online sterilization, namely putting the pseudo-ginseng into an ozone sterilization box, and sterilizing the pseudo-ginseng under different pressures by using different gases until the pseudo-ginseng reaches related specified indexes;
pulping to obtain juice, adding a proper amount of sterile water, crushing the pseudo-ginseng slices by using a high-speed universal crusher to obtain the juice, and pre-freezing the fresh juice in an ultra-low temperature freezer;
step five, drying the medicine cake, namely putting the pre-frozen fresh juice into a vacuum low-temperature drying oven, performing vacuum low-temperature drying on the juice, determining the optimal drying temperature and vacuum degree, performing resolution drying, slowly raising the temperature, keeping the temperature for a period of time, observing the pressure condition in the drying oven, and finishing freeze drying;
step six, crushing and sieving, crushing, determining the optimal crushing temperature, crushing and sieving until no residue exists;
and seventhly, packaging and detecting, namely, vacuum packaging is adopted, and meanwhile, microorganism detection is carried out.
Step one, measuring chemical components in the pseudo-ginseng by adopting an HPLC (high performance liquid chromatography) technology, distinguishing the pseudo-ginseng with different producing areas and different picking times and determining an accurate source.
Washing with flowing water, spreading the sheet Notoginseng radix on a mesh tray, standing in natural environment, and draining for 10-15 min.
And step three, inspecting three gases of gasified hydrogen peroxide, ozone and ethylene oxide, sterilizing at different temperatures and pressures for different time, and checking the sterilized decoction pieces for microorganisms to determine the optimal online sterilization time.
And step four, adding a small amount of sterile water according to the water content of the original medicine, pulping, filtering until the residue is lower than 2-3% of the original medicine, and pre-freezing at a high temperature, a medium temperature and a low temperature respectively to ensure that the pre-freezing is most complete and the time is shortest as the optimal pre-freezing temperature.
And step five, performing vacuum low-temperature drying under the conditions of high vacuum degree, medium vacuum degree and low vacuum degree respectively, determining the optimal drying temperature and vacuum degree, raising the temperature after drying, closing the condenser, observing for 30-60s, and finishing freeze drying if the pressure in the freeze drying box is not obviously raised.
And step six, crushing at a high temperature, a medium temperature and a low temperature, crushing for 2-10min at an optimal crushing temperature which is convenient to crush and energy-saving, sieving by using a 100-mesh sieve, and crushing and sieving residues until no residues exist.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A process flow of freeze-dried traditional Chinese medicine pseudo-ginseng powder is characterized by comprising the following steps:
selecting materials, selecting a good production place according to the production environment of the pseudo-ginseng, selecting the pseudo-ginseng, ensuring the integrity of raw materials and avoiding rotting, and cleaning the raw materials to avoid impurity residues;
cutting the pseudo-ginseng into slices according to the characteristics of the pseudo-ginseng, and cleaning and draining the pseudo-ginseng;
step three, online sterilization, namely putting the pseudo-ginseng into an ozone sterilization box, and sterilizing the pseudo-ginseng under different pressures by using different gases until the pseudo-ginseng reaches related specified indexes;
pulping to obtain juice, adding a proper amount of sterile water, crushing the pseudo-ginseng slices by using a high-speed universal crusher to obtain the juice, and pre-freezing the fresh juice in an ultra-low temperature freezer;
step five, drying the medicine cake, namely putting the pre-frozen fresh juice into a vacuum low-temperature drying oven, performing vacuum low-temperature drying on the juice, determining the optimal drying temperature and vacuum degree, performing resolution drying, slowly raising the temperature, keeping the temperature for a period of time, observing the pressure condition in the drying oven, and finishing freeze drying;
step six, crushing and sieving, crushing, determining the optimal crushing temperature, crushing and sieving until no residue exists;
and seventhly, packaging and detecting, namely, vacuum packaging is adopted, and meanwhile, microorganism detection is carried out.
2. The technological process of the freeze-dried traditional Chinese medicine pseudo-ginseng powder according to claim 1, which is characterized in that: in the first step, the HPLC technology is adopted to measure chemical components in the pseudo-ginseng, and pseudo-ginseng with different producing areas and different picking times is distinguished to determine an accurate source.
3. The technological process of the freeze-dried traditional Chinese medicine pseudo-ginseng powder according to claim 1, which is characterized in that: the steps are washed once by using flowing water, and then the thin pseudo-ginseng slices are spread in a net-shaped tray and placed in a natural environment for draining for 10-15 min.
4. The technological process of the freeze-dried traditional Chinese medicine pseudo-ginseng powder according to claim 1, which is characterized in that: and step three, three gases of gasified hydrogen peroxide, ozone and ethylene oxide are inspected, the sterilization is carried out for different time at different temperatures and pressures, and the sterilized decoction pieces are subjected to microbial inspection to determine the optimal online sterilization time.
5. The technological process of the freeze-dried traditional Chinese medicine pseudo-ginseng powder according to claim 1, which is characterized in that: and step four, adding a small amount of sterile water according to the water content of the original medicine, pulping, filtering until the residue is lower than 2-3% of the original medicine, and pre-freezing at a high temperature, a medium temperature and a low temperature respectively to ensure that the pre-freezing is most complete and the time is shortest as the optimal pre-freezing temperature.
6. The technological process of the freeze-dried traditional Chinese medicine pseudo-ginseng powder according to claim 1, which is characterized in that: and step five, performing vacuum low-temperature drying under the conditions of high vacuum degree, medium vacuum degree and low vacuum degree respectively, determining the optimal drying temperature and vacuum degree, raising the temperature after drying, closing the condenser, observing for 30-60s, and finishing freeze drying if the pressure in the freeze drying box is not obviously raised.
7. The technological process of the freeze-dried traditional Chinese medicine pseudo-ginseng powder according to claim 1, which is characterized in that: and in the sixth step, the high temperature, the medium temperature and the low temperature are selected for crushing, the crushing is carried out for 2-10min at the optimal crushing temperature which is convenient to crush and energy-saving, the crushed materials are sieved by a 100-mesh sieve, and the residues are crushed and sieved until no residues exist.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112229148A (en) * | 2020-10-21 | 2021-01-15 | 湖北金贵中药饮片有限公司 | Vacuum freeze-drying method for pseudo-ginseng and application thereof |
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- 2021-04-12 CN CN202110387278.9A patent/CN113143983A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112229148A (en) * | 2020-10-21 | 2021-01-15 | 湖北金贵中药饮片有限公司 | Vacuum freeze-drying method for pseudo-ginseng and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴飞等: "三七生粉入药灭菌工艺的选择", 《中国医药导报》 * |
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Application publication date: 20210723 |