CN113134110A - PVP/PVB slow-release nano-fiber medical dressing and preparation method and application thereof - Google Patents
PVP/PVB slow-release nano-fiber medical dressing and preparation method and application thereof Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
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- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/10—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained by reactions only involving carbon-to-carbon unsaturated bonds as constituent
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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Abstract
The invention belongs to the technical field of medicines, and particularly discloses a PVP/PVB slow-release nanofiber medical dressing as well as a preparation method and application thereof. The preparation method of the PVP/PVB slow-release nano-fiber medical dressing specifically comprises the following steps: mixing PVP (polyvinyl pyrrolidone) and PVB (polyvinyl butyral) with absolute ethyl alcohol, adding an active substance, and continuously mixing to prepare a spinning solution containing the active substance; then the PVP/PVB slow release nano fiber medical dressing is prepared through electrostatic spinning. The nanofiber medical dressing prepared by the invention not only has good air permeability and high porosity, but also can keep the wound moist and is beneficial to the respiration of cells. The nanofiber can effectively prevent bacteria in the air from contacting with particles to the whole wound, and the nanofiber slow-release medical dressing prepared by mixing and spinning with PVB has high strength due to the ingenious utilization of the characteristic of PVP, so that the nanofiber slow-release medical dressing is very suitable for being used as a film material of the medical dressing.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a PVP/PVB slow-release nanofiber medical dressing as well as a preparation method and application thereof.
Background
Traditional medical dressing mainly uses absorbent cotton gauze to prepare for the base cloth, applies on the wound, takes place the adhesion with skin in the wound healing process, changes the dressing and can produce secondary damage to the wound, causes the misery for patient. The medical dressing film prepared by the coating method can be applied better than the traditional cotton gauze, but is airtight and cannot absorb the exudates of the skin and the like. The nanofiber membrane prepared by the electrostatic spinning technology has high porosity and good air permeability, so that the wound can keep an ideal moisture degree, and the respiration of cells is facilitated. On the other hand, the nanofiber membrane can filter out most of bacteria and dust in the air, so that the wound is prevented from being infected. For the reasons, the nanofiber forming has wide application prospect in the field of medical dressings.
Disclosure of Invention
The invention aims to provide a PVP/PVB slow-release nano-fiber medical dressing and a preparation method thereof. The polyvinyl pyrrolidone (PVP) can be dissolved in organic solvents such as ethanol and the like and is easy to dissolve in water, and is blended with polyvinyl butyral (PVB), so that the product has the advantages of high fiber strength, good application property, good air permeability, capability of absorbing tissue exudate, isolation of bacteria and particles in air and prevention of secondary infection.
The invention also aims to provide the PVP/PVB slow-release nanofiber membrane medical dressing prepared by the method. The medical dressing has the advantages that the use is simple and convenient, the strength of the fiber membrane is high, the active ingredients of the periplaneta americana are gradually released to the wound, and the defects that the general medical dressing is poor in dressing property and easy to cause secondary damage, the general nanofiber medical dressing is poor in strength in water and the like are overcome.
The invention further aims to provide application of the periplaneta americana slow-release nanofiber membrane medical dressing in preparation of wound dressings.
The purpose of the invention is realized by the following technical scheme:
a preparation method of PVP/PVB slow release nano fiber medical dressing specifically comprises the following steps:
mixing PVP and PVB with absolute ethyl alcohol, adding an active substance, and continuously mixing to prepare PVP/PVB spinning solution containing the active substance; then the PVP/PVB slow release nano fiber medical dressing is prepared through electrostatic spinning.
The mass ratio of the PVP to the PVB is 1: 1-5, and preferably 1: 2. The total mass fraction of PVP and PVAB in the PVP/PVB spinning solution is 8-12 wt%, and the preference is 10 wt%.
The active substance is at least one of Periplaneta americana rehabilitation new liquid, acetyl hexapeptide-8, snake venom like peptide, disodium glycyrrhizinate and instantaneous wrinkle-smoothing agent. Preferably, the solid content of the periplaneta americana rehabilitation new liquid is 30%.
The mass ratio of the active substance to the PVP is 5-12: 1-10, preferably 5-12: 2-5.
The temperature of the first mixing is 20-70 ℃, and the mixing time is 3-10 h; preferably, the temperature of the first mixing is 60 ℃ and the mixing time is 5 h.
The temperature of the second mixing is room temperature, and the mixing time is 3-7 h; preferably 5 h.
The electrostatic spinning conditions are that the temperature is 20-28 ℃, and the humidity is 38-48% RH; setting the spinning conditions as follows: the injection speed is 5.0-15.0 mm/h, the receiving distance is 17-23 cm, and the spinning voltage is 20-25 kV. Preferably, the experiment is carried out at the ambient temperature of 25 ℃ and the humidity of 45% RH; setting the spinning conditions as follows: the injection speed was 10.0mm/h, the take-up distance was 20cm, and the spinning voltage was 23 kV.
The PVP/PVB slow-release nanofiber medical dressing is prepared according to the method.
The PVP/PVB slow release nano fiber medical dressing is applied to the preparation of wound dressings.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) PVP nanofibers are well hydrophilic but poorly strong, dissolving too quickly in water. The PVB nano-fiber has high strength and poor hydrophilicity. The nanofiber prepared by mixing PVP and PVB has high strength and good hydrophilicity. When the PVP/PVB nanofiber medical dressing meets water, PVP macromolecular chains in the fibers can be quickly unfolded in the water, and PVB macromolecular chains can be kept stable in the water. Because PVP and PVB macromolecular chains are intertwined in ethanol, the PVP and PVB macromolecular chains are recrystallized and oriented through an electrostatic spinning process, namely when PVP/PVB nano-fibers are in water, the PVB macromolecular chains can hinder the stretching of PVP macromolecular chains. Therefore, the macromolecular chain of PVP is stretched in water to be a gradual process, and the active ingredients wrapped in the nano-fiber are gradually released along with the stretching of the macromolecular chain of PVP.
(2) The PVP is mixed with the PVB, then the PVP is dissolved by using the ethanol and is prepared into spinning solution together with active substances, and the PVP/PVB slow-release medical dressing is prepared by using electrostatic spinning equipment.
(3) Different from the traditional preparation idea of medical dressing, the invention directly mixes the active substance with PVB and PVP to prepare spinning solution, and uses electrostatic spinning to directly prepare the nano-fiber medical dressing with slow release effect. The nanofiber medical dressing is directly pasted on the wound for use.
(4) Compared with common nanofiber medical dressings, the nanofiber medical dressing has good air permeability and high porosity, and can keep wounds moist and facilitate the respiration of cells. The nanofiber can effectively prevent bacteria in the air from contacting with particles to the whole wound, and the nanofiber slow-release medical dressing prepared by mixing and spinning with PVB has high strength due to the ingenious utilization of the characteristic of PVP, so that the nanofiber slow-release medical dressing is very suitable for being used as a film material of the medical dressing.
Drawings
FIG. 1 is an electron microscope image of the nanofiber prepared in example 1 and having a sustained-release effect.
FIG. 2 is a graph showing the change of the concentration of phenylalanine in water with respect to the soaking time in example 1.
FIG. 3 is a graph showing the change of the concentration of phenylalanine in water with respect to the soaking time in example 2.
FIG. 4 is a graph showing the change of the concentration of phenylalanine in water with respect to the soaking time in example 3.
FIG. 5 is a graph showing the change of the concentration of phenylalanine in water with respect to the soaking time in example 4.
FIG. 6 is a graph showing the change of the concentration of phenylalanine in water with respect to the soaking time in example 5.
FIG. 7 is a force diagram before and after infiltration of the sustained-release nanofiber medical dressing obtained in examples 1 to 5.
Detailed Description
The present invention will be described in further detail with reference to examples and drawings, but the embodiments of the present invention are not limited thereto. The room temperature and the unspecified temperature are both 20-35 ℃.
The reagents used in the examples are commercially available without specific reference.
PVP is purchased from Shanghai Michelin Biotechnology Ltd, PVP k-90; PVB was purchased from Shanghai Michelin Biochemical technology, Inc., PVB MW, 90000-120000. The periplaneta americana rehabilitation new liquid is purchased from Sichuan good doctors and Panxi pharmaceutical industry, Limited liability company.
Example 1
A preparation method of a Periplaneta americana slow-release nanofiber medical dressing comprises the following steps:
(1) PVP2g and PVB10g are weighed by an electronic balance and put into a clean conical flask, after the mass ratio of solute to solvent is calculated, 100g of absolute ethyl alcohol is added into the conical flask, the conical flask is stirred in a water bath kettle at the temperature of 50 ℃ for 5 hours, the conical flask is cooled to the room temperature, 10g of periplaneta americana rehabilitation new liquid is added at the room temperature, and then the stirring is carried out for 5 hours to prepare the periplaneta americana @ PVP/PVB spinning solution. Setting the spinning conditions as follows: the injection speed is 10.0mm/h, the receiving distance is 20cm, the spinning voltage is 23kV, and the periplaneta americana @ PVP/PVB nanofiber membrane is prepared by using a single-needle electrostatic spinning machine.
An electron microscope image of the nanofiber prepared by electrostatic spinning and having a slow release effect is shown in fig. 1. The periplaneta americana rehabilitation new liquid is a mixture, phenylalanine in the periplaneta americana rehabilitation new liquid is selected as a calibration object, 0.01 g of nanofiber membrane is placed into a sample tube, 1mL of pure water is injected, the soaking time of the nanofiber membrane is controlled, and the concentration of phenylalanine in the aqueous solution of the nanofiber membrane is tested by using a high performance liquid chromatograph. The trend of phenylalanine concentration in water with soaking time is shown in fig. 2. The strength of the slow-release nanofiber medical dressing before and after infiltration is shown in fig. 7.
Example 2
A preparation method of a Periplaneta americana slow-release nanofiber medical dressing comprises the following steps:
(1) weighing a proper amount of PVP2g and PVB5g by using an electronic balance, wherein the mass ratio of the PVP to the PVB is 2: 5. And after the mass ratio of the solute to the solvent is calculated, adding 60g of absolute ethyl alcohol into a conical flask, stirring for 5 hours in a water bath kettle at the temperature of 60 ℃, adding 5g of periplaneta americana rehabilitation new liquid at room temperature, and stirring for 4 hours to prepare the periplaneta americana @ PVP/PVB spinning solution. Setting the spinning conditions as follows: the injection speed is 5.0mm/h, the receiving distance is 22cm, the spinning voltage is 25kV, and the periplaneta americana @ PVP/PVB spinning nanofiber membrane is prepared by using a single-needle electrostatic spinning machine.
The periplaneta americana rehabilitation new liquid is a mixture, phenylalanine is selected as a calibration object, 0.01 g of nanofiber membrane is placed into a sample tube, 1mL of pure water is injected, the soaking time of the nanofiber membrane is controlled, and the concentration of phenylalanine in the water solution is tested by using a high performance liquid chromatograph. The trend of phenylalanine concentration in water with soaking time is shown in fig. 3. The strength of the slow-release nanofiber medical dressing before and after infiltration is shown in fig. 7.
Example 3
A preparation method of a Periplaneta americana slow-release nanofiber medical dressing comprises the following steps:
(1) appropriate amounts of PVP 3g and PVB5g were weighed with an electronic balance. And calculating the mass ratio of the solute to the solvent, adding 60g of absolute ethyl alcohol into a conical flask, stirring for 6 hours in a water bath kettle at the temperature of 55 ℃, adding 10g of periplaneta americana rehabilitation new liquid at room temperature, and stirring for 5 hours to prepare the periplaneta americana @ PVP/PVB spinning solution. Setting the spinning conditions as follows: the injection speed is 8.0mm/h, the receiving distance is 21cm, the spinning voltage is 24kV, and the periplaneta americana @ PVP/PVB nanofiber membrane is prepared by using a single-needle electrostatic spinning machine.
The periplaneta americana rehabilitation new liquid is a mixture, phenylalanine is selected as a calibration object, 0.01 g of nanofiber membrane is placed into a sample tube, 1mL of pure water is injected, the soaking time of the nanofiber membrane is controlled, and the concentration of phenylalanine in the water solution is tested by using a high performance liquid chromatograph. The trend of phenylalanine concentration in water with soaking time is shown in fig. 4. The strength of the slow-release nanofiber medical dressing before and after infiltration is shown in fig. 7.
Example 4
A preparation method of a Periplaneta americana slow-release nanofiber medical dressing comprises the following steps:
(1) weighing a proper amount of PVP4g and PVB5g by using an electronic balance, calculating the mass ratio of solute to solvent, adding 90g of absolute ethyl alcohol into a conical flask, stirring for 6h in a water bath kettle at the temperature of 65 ℃, adding 10g of periplaneta americana rehabilitation new liquid at room temperature, and stirring for 3h to prepare the periplaneta americana @ PVP/PVB spinning solution. Setting the spinning conditions as follows: the injection speed is 12mm/h, the receiving distance is 17cm, the spinning voltage is 21kV, and the periplaneta americana @ PVP/PVB nanofiber membrane is prepared by using a single-needle electrostatic spinning machine.
The periplaneta americana rehabilitation new liquid is a mixture, phenylalanine is selected as a calibration object, 0.01 g of nanofiber membrane is placed into a sample tube, 1ml of pure water is injected, the soaking time of the nanofiber membrane is controlled, and the concentration of phenylalanine in the water solution is tested by using a high performance liquid chromatograph. The trend of phenylalanine concentration in water with soaking time is shown in fig. 5. The strength of the slow-release nanofiber medical dressing before and after infiltration is shown in fig. 7.
Example 5
A preparation method of a Periplaneta americana slow-release nanofiber medical dressing comprises the following steps:
(1) appropriate amounts of PVP5g and PVB5g were weighed using an electronic balance. After the mass ratio of the solute to the solvent is calculated, 110g of absolute ethyl alcohol is added into a conical flask, stirring is carried out in a water bath kettle at the temperature of 70 ℃ for 6 hours, 12g of periplaneta americana rehabilitation new liquid is added at the room temperature, and stirring is carried out for 5 hours, so that the periplaneta americana @ PVP/PVB spinning solution is prepared. Setting the spinning conditions as follows: the injection speed is 15.0mm/h, the receiving distance is 23cm, the spinning voltage is 25kV, and the American cockroach @ PVP/PVB nano fiber membrane is prepared by using a self-made single-needle electrostatic spinning machine.
The periplaneta americana rehabilitation new liquid is a mixture, phenylalanine is selected as a calibration object, 0.01 g of nanofiber membrane is placed into a sample tube, 1mL of pure water is injected, the soaking time of the nanofiber membrane is controlled, and the concentration of phenylalanine in the water solution is tested by using a high performance liquid chromatograph. The trend of phenylalanine concentration in water with soaking time is shown in fig. 6. The strength of the slow-release nanofiber medical dressing before and after infiltration is shown in fig. 7.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. A preparation method of PVP/PVB slow release nano fiber medical dressing is characterized by comprising the following steps:
mixing PVP and PVB with absolute ethyl alcohol, adding an active substance, and continuously mixing to prepare PVP/PVB spinning solution containing the active substance; then the PVP/PVB slow release nano fiber medical dressing is prepared through electrostatic spinning.
2. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1, wherein: the mass ratio of the PVP to the PVB is 1: 1-5.
3. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1 or 2, wherein: the total mass fraction of PVP and PVAB in the PVP/PVB spinning solution is 8-12 wt%.
4. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1, wherein: the mass ratio of PVP to PVB is 1: 2; the PVP/PVB spinning solution is 10 wt%.
5. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1, wherein: the active substance is at least one of Periplaneta americana rehabilitation new liquid, acetyl hexapeptide-8, snake venom like peptide, disodium glycyrrhizinate and instantaneous wrinkle-smoothing agent.
6. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1, wherein: the mass ratio of the active substance to the PVP is 5-12: 1-10.
7. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1, wherein: the temperature of the first mixing is 20-70 ℃, and the mixing time is 3-10 h; the temperature of the second mixing is room temperature, and the mixing time is 3-7 h.
8. The method for preparing the PVP/PVB slow release nanofiber medical dressing as claimed in claim 1, wherein: the electrostatic spinning conditions are that the temperature is 20-28 ℃, and the humidity is 38-48% RH; setting the spinning conditions as follows: the injection speed is 5.0-15.0 mm/h, the receiving distance is 17-23 cm, and the spinning voltage is 20-25 kV.
9. A PVP/PVB slow release nanofiber medical dressing prepared by the method according to any one of claims 1-8.
10. Use of the PVP/PVB slow release nanofiber medical dressing of claim 9 in the preparation of a wound dressing.
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| CN114150442A (en) * | 2021-12-09 | 2022-03-08 | 吉林大学 | Garlicin-loaded antibacterial packaging film and preparation method thereof |
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