CN113133998A - Calcium-zinc oral liquid and preparation method thereof - Google Patents
Calcium-zinc oral liquid and preparation method thereof Download PDFInfo
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- CN113133998A CN113133998A CN202110390173.9A CN202110390173A CN113133998A CN 113133998 A CN113133998 A CN 113133998A CN 202110390173 A CN202110390173 A CN 202110390173A CN 113133998 A CN113133998 A CN 113133998A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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Abstract
The invention provides a calcium-zinc oral liquid which comprises the following components in parts by weight: 2-5 parts of calcium gluconate; 2-5 parts of L-calcium lactate; 0.05 to 0.15 portion of zinc gluconate; 1.5-3 parts of a flavoring agent; 0.2 to 1.5 portions of bacteriostatic agent; 80-90 parts of purified water. The oral liquid is suitable for children to supplement calcium and zinc, and has the advantages of accurate measurement, no essence and antiseptic, and good taste. The invention also provides a preparation method of the calcium-zinc oral liquid.
Description
Technical Field
The invention relates to the technical field of medicines, and particularly relates to a calcium-zinc oral liquid.
Background
The zinc is one of the essential trace elements in human body, and the latest investigation result shows that the zinc deficiency rate of children in China is as high as 60%, the daily zinc intake is less than half of the recommended amount, and the zinc deficiency directly causes low immunity of the children, influences the growth and development of the children, and causes serious consequences such as short stature or poor intelligence development. In addition, Chinese people generally lack calcium, and children are easy to lack calcium, which can cause anorexia and monophagia; is not easy to fall asleep and easy to wake up; the cold is easy to occur; thinning hair; mental retardation; irregular walk learning and teething; paroxysmal abdominal pain and diarrhea; an X or O leg; chicken breast and other diseases.
The constitution of children is delicate, the products which are required to be supplemented with calcium and zinc in the market at present have wide age coverage, and the dosage of the products is low in specificity to the children. And the formula contains essence and preservative, so that the calcium and zinc supplement is not suitable for children. The invention aims to provide the calcium-zinc oral liquid for solving the problems.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides the calcium-zinc oral liquid which is suitable for children, has accurate measurement, no essence and preservative, good taste and can realize simultaneous calcium and zinc supplementation.
In order to achieve the purpose, the calcium-zinc oral liquid comprises the following components in parts by weight:
further, the flavoring agent is white granulated sugar, and the weight part of the white granulated sugar is 2 parts.
Furthermore, the bacteriostatic agent adopts lactic acid, and the weight part of the lactic acid is 1 part.
Further, the weight parts of calcium gluconate, L-calcium lactate and zinc gluconate are respectively 3, 3 and 0.1 respectively.
Further, the weight part of the purified water was 85 parts.
The invention also provides a preparation method of the calcium-zinc oral liquid, which comprises the following steps:
s1: heating purified water accounting for 80% of the total volume to boil;
s2: sequentially adding the calcium gluconate, the L-calcium lactate, the white granulated sugar, the zinc gluconate and the lactic acid in the prescription amount into the purified water, and stirring until the calcium gluconate, the L-calcium lactate, the white granulated sugar, the zinc gluconate and the lactic acid are completely dissolved;
s3: stopping heating, coarse filtering, adding purified water to desired volume, stirring, fine filtering, and testing pH value and calcium content;
s4: filling into oral liquid bottle, sterilizing, lamp-inspecting, packaging and warehousing.
Further, in step S2, after the solution was completely dissolved, medicinal charcoal was added and stirred to disperse the solution uniformly, and the solution was continuously heated and boiled for 30 minutes, and the heating was stopped.
Further, in step S3, the solution is first subjected to a rough filtration by a stainless steel frame, and then subjected to a fine filtration by a two-stage filter after volume metering.
The calcium-zinc oral liquid is suitable for children, accurate in metering, free of essence and preservative, good in taste and capable of achieving calcium-zinc simultaneous supplement.
Drawings
The present invention will be further described and illustrated with reference to the following drawings.
Fig. 1 is a flow chart of a method for preparing a calcium-zinc oral liquid according to a preferred embodiment of the present invention.
Detailed Description
The technical solution of the present invention will be more clearly and completely explained by the description of the preferred embodiments of the present invention with reference to the accompanying drawings.
Example 1: the preparation method of the calcium-zinc oral liquid comprises the following steps:
s1: adding 64kg of purified water into a first liquid preparation tank, heating and boiling;
s2: sequentially adding 2kg of calcium gluconate, 2 kgL-calcium lactate, 1.5kg of white granulated sugar, 0.05kg of zinc gluconate and 0.2kg of lactic acid into purified water, stirring until the calcium gluconate, the calcium lactate, the white granulated sugar and the lactic acid are completely dissolved, adding medicinal carbon, stirring to uniformly disperse the medicinal carbon, continuously heating and boiling for 30 minutes, and stopping heating;
s3: refluxing and roughly filtering the mixture by a stainless steel plate frame to a second liquid preparation tank, adding 16kg of purified water, fixing the volume of the water, uniformly stirring, finely filtering the mixture by a two-stage filter element filter, and sampling to detect the property and the pH value of the liquid medicine;
s4: is filled toSoda-lime glass tubeAnd (4) carrying out microwave sterilization, lamp inspection and packaging on the oral liquid bottles, and warehousing the finished products after the finished products are qualified.
Example 2: the preparation method of the calcium-zinc oral liquid comprises the following steps:
s1: adding 72kg of purified water into a first liquid preparation tank, heating and boiling;
s2: adding 5kg of calcium gluconate, 5 kgL-calcium lactate, 3kg of white granulated sugar, 0.15kg of zinc gluconate and 1.5kg of lactic acid into purified water in sequence, stirring until the calcium gluconate, the calcium lactate, the white granulated sugar and the zinc gluconate are completely dissolved, adding medicinal carbon, stirring to uniformly disperse the medicinal carbon, continuously heating and boiling for 30 minutes, and stopping heating;
s3: refluxing and roughly filtering the mixture by a stainless steel plate frame to a second liquid preparation tank, adding 18kg of purified water, fixing the volume of the water, uniformly stirring, finely filtering the mixture by a two-stage filter element filter, and sampling to detect the property and the pH value of the liquid medicine;
s4: is filled toSoda-lime glass tubeAnd (4) carrying out microwave sterilization, lamp inspection and packaging on the oral liquid bottles, and warehousing the finished products after the finished products are qualified.
Example 3: the preparation method of the calcium-zinc oral liquid comprises the following steps:
s1: adding 68kg of purified water into a first liquid preparation tank, heating and boiling;
s2: sequentially adding 3kg of calcium gluconate, 3 kgL-calcium lactate, 2kg of white granulated sugar, 0.1kg of zinc gluconate and 1kg of lactic acid into the purified water, stirring until the calcium gluconate, the calcium lactate, the white granulated sugar and the zinc gluconate are completely dissolved, adding medicinal carbon, stirring to uniformly disperse the medicinal carbon, continuously heating and boiling for 30 minutes, and stopping heating;
s3: refluxing and roughly filtering the mixture by a stainless steel plate frame to a second liquid preparation tank, adding 17kg of purified water, fixing the volume of the water, uniformly stirring, finely filtering the mixture by a two-stage filter element filter, and sampling to detect the property and the pH value of the liquid medicine;
s4: is filled toSoda-lime glass tubeAnd (4) carrying out microwave sterilization, lamp inspection and packaging on the oral liquid bottles, and warehousing the finished products after the finished products are qualified.
Example 4: the preparation method of the calcium-zinc oral liquid comprises the following steps:
s1: adding 64kg of purified water into a first liquid preparation tank, heating and boiling;
s2: adding 5kg of calcium gluconate, 5 kgL-calcium lactate, 3kg of white granulated sugar, 0.15kg of zinc gluconate and 1.5kg of lactic acid into purified water in sequence, stirring until the calcium gluconate, the calcium lactate, the white granulated sugar and the zinc gluconate are completely dissolved, adding medicinal carbon, stirring to uniformly disperse the medicinal carbon, continuously heating and boiling for 30 minutes, and stopping heating;
s3: refluxing and roughly filtering the mixture by a stainless steel plate frame to a second liquid preparation tank, adding 16kg of purified water, fixing the volume of the water, uniformly stirring, finely filtering the mixture by a two-stage filter element filter, and sampling to detect the property and the pH value of the liquid medicine;
s4: is filled toSoda-lime glass tubeAnd (4) carrying out microwave sterilization, lamp inspection and packaging on the oral liquid bottles, and warehousing the finished products after the finished products are qualified.
Example 5: the preparation method of the calcium-zinc oral liquid comprises the following steps:
s1: adding 72kg of purified water into a first liquid preparation tank, heating and boiling;
s2: sequentially adding 2kg of calcium gluconate, 2 kgL-calcium lactate, 1.5kg of white granulated sugar, 0.05kg of zinc gluconate and 0.2kg of lactic acid into purified water, stirring until the calcium gluconate, the calcium lactate, the white granulated sugar and the lactic acid are completely dissolved, adding medicinal carbon, stirring to uniformly disperse the medicinal carbon, continuously heating and boiling for 30 minutes, and stopping heating;
s3: refluxing and roughly filtering the mixture by a stainless steel plate frame to a second liquid preparation tank, adding 18kg of purified water, fixing the volume of the water, uniformly stirring, finely filtering the mixture by a two-stage filter element filter, and sampling to detect the property and the pH value of the liquid medicine;
s4: is filled toSoda-lime glass tubeAnd (4) carrying out microwave sterilization, lamp inspection and packaging on the oral liquid bottles, and warehousing the finished products after the finished products are qualified.
The calcium-zinc oral liquid is suitable for children, accurate in metering, free of essence and preservative, good in taste and capable of achieving calcium-zinc simultaneous supplement.
The above detailed description merely describes preferred embodiments of the present invention and does not limit the scope of the invention. Without departing from the spirit and scope of the present invention, it should be understood that various changes, substitutions and alterations can be made herein by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents. The scope of the invention is defined by the claims.
Claims (8)
1. The calcium-zinc oral liquid is characterized by comprising the following components in parts by weight:
2. the calcium-zinc oral liquid of claim 1, wherein the flavoring agent is white granulated sugar, and the white granulated sugar is 2 parts by weight.
3. The calcium-zinc oral liquid according to claim 1, wherein the bacteriostatic agent is lactic acid, and the weight part of the lactic acid is 1 part.
4. The calcium-zinc oral liquid according to claim 1, wherein the calcium gluconate is 3 parts by weight, the L-calcium lactate is 3 parts by weight, and the zinc gluconate is 0.1 part by weight.
5. The calcium-zinc oral liquid according to claim 1, wherein the purified water is 85 parts by weight.
6. The preparation method of the calcium-zinc oral liquid according to any one of claims 1 to 5, characterized by comprising the following steps:
s1: heating purified water accounting for 80% of the total volume to boil;
s2: sequentially adding the calcium gluconate, the L-calcium lactate, the white granulated sugar, the zinc gluconate and the lactic acid in the prescription amount into the purified water, and stirring until the calcium gluconate, the L-calcium lactate, the white granulated sugar, the zinc gluconate and the lactic acid are completely dissolved;
s3: stopping heating, coarse filtering, adding purified water to desired volume, stirring, fine filtering, and testing pH value and calcium content;
s4: filling into oral liquid bottle, sterilizing, lamp-inspecting, packaging and warehousing.
7. The method of claim 6, wherein the calcium-zinc oral liquid is prepared by dissolving completely in step S2, adding medicinal charcoal, stirring to disperse uniformly, boiling for 30 min, and stopping heating.
8. The method of claim 6, wherein in step S3, the solution is first filtered by stainless steel frame reflux coarse filtration, and then filtered by two-stage filter element fine filtration after constant volume.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110390173.9A CN113133998A (en) | 2021-04-12 | 2021-04-12 | Calcium-zinc oral liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110390173.9A CN113133998A (en) | 2021-04-12 | 2021-04-12 | Calcium-zinc oral liquid and preparation method thereof |
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| Publication Number | Publication Date |
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| CN113133998A true CN113133998A (en) | 2021-07-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110390173.9A Pending CN113133998A (en) | 2021-04-12 | 2021-04-12 | Calcium-zinc oral liquid and preparation method thereof |
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|---|---|
| CN (1) | CN113133998A (en) |
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2021
- 2021-04-12 CN CN202110390173.9A patent/CN113133998A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 火爆孕婴童招商网: "葡萄糖酸钙乳酸钙葡萄糖酸锌口服液", 《HTTP://WWW.1288.TV/INFORMATION/SHOWCONTENT_84228.HTML》 * |
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Application publication date: 20210720 |