CN113117266A - Temperature monitoring equipment - Google Patents
Temperature monitoring equipment Download PDFInfo
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- CN113117266A CN113117266A CN201911395793.0A CN201911395793A CN113117266A CN 113117266 A CN113117266 A CN 113117266A CN 201911395793 A CN201911395793 A CN 201911395793A CN 113117266 A CN113117266 A CN 113117266A
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- ultrasonic
- ultrasonic wave
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4411—Device being modular
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K13/00—Thermometers specially adapted for specific purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
Abstract
The present invention provides a temperature monitoring device comprising: the ultrasonic transmitting module is used for transmitting test ultrasonic waves to a preset area inside an object; the ultrasonic receiving module is used for receiving the test transmission ultrasonic waves generated by the object on the side away from the sound source of the test ultrasonic waves; and the calculation module is used for obtaining the temperature of the area of one side of the preset area, which is far away from the sound source, according to the detection time from the test ultrasonic wave sent by the ultrasonic sending module to the test transmission ultrasonic wave received by the ultrasonic receiving module. In the temperature monitoring device provided by the invention, the calculation module can acquire the detection time between the real-time test ultrasonic wave sent by the ultrasonic sending module and the test transmission ultrasonic wave received by the ultrasonic receiving module, and directly acquire the current temperature of the back tissue according to the corresponding relation between the detection time and the temperature, so that the temperature of the back tissue is efficiently monitored in real time in the ultrasonic ablation treatment process.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to temperature monitoring equipment.
Background
Ultrasonic ablation refers to the process of collecting the energy of ultrasonic waves to a sufficient intensity by utilizing the characteristic that the ultrasonic waves can pass through human tissues and are focused in a specific area, so that the collected focal area (namely a focal area) reaches an instant high temperature to destroy the pathological change tissue, and the pathological change tissue shows coagulative necrosis (namely ablation) on the histopathology, thereby achieving the purpose of destroying the pathological change tissue on the premise of not damaging normal tissues. The technology and related products have been proved on the treatment of diseases such as hysteromyoma after years of practice, and revolutionary changes are generated in the traditional surgery.
In the existing ultrasound ablation technology, temperature detection is usually performed on the lesion at the end of treatment to determine whether the focal zone temperature exceeds a predetermined standard, so as to avoid damage to the human body due to overhigh focal zone temperature. However, in the process of ultrasonic ablation, not only the focal region tissue is affected by temperature, but also healthy tissue near the focal region (especially the back tissue) is damaged by the energy of the ultrasonic transmission signal when the treatment is excessive, but the temperature of the back tissue cannot be timely detected and monitored by the existing ultrasonic ablation device.
Therefore, how to provide a temperature monitoring device for a back surface tissue becomes a technical problem to be solved in the field.
Disclosure of Invention
The present disclosure is directed to providing a temperature monitoring apparatus capable of monitoring a focal zone temperature in real time and efficiently.
To solve the above technical problem, as an aspect of the present invention, there is provided a temperature monitoring apparatus, the apparatus including:
an ultrasonic transmission module for transmitting a test ultrasonic wave to a predetermined region inside an object;
an ultrasonic receiving module for receiving a test transmission ultrasonic wave generated by the object on a side away from a sound source of the test ultrasonic wave;
and the calculation module is used for obtaining the temperature of the area of one side, away from the sound source, of the preset area according to the detection time from the test ultrasonic wave sent by the ultrasonic sending module to the test transmission ultrasonic wave received by the ultrasonic receiving module.
Optionally, the device further comprises a temperature detection element for detecting a reference temperature of an area on a side of the predetermined area facing away from the sound source (i.e., an area where the back tissue is located);
the ultrasonic transmitting module is also used for transmitting reference ultrasonic waves to a preset area inside the object;
the ultrasonic receiving module is also used for receiving reference transmission ultrasonic waves generated by the object on the side away from the sound source;
the calculation module includes a reference recording unit configured to record sound wave information of the reference transmitted ultrasonic wave, the sound wave information including a reference time elapsed from the transmission of the reference ultrasonic wave by the ultrasonic transmission module to the reception of the reference transmitted ultrasonic wave by the ultrasonic reception module.
Optionally, the calculation module further comprises a time analysis unit and a temperature calculation unit, wherein,
the time analysis unit is used for obtaining a time difference between the detection time and the reference time;
the temperature calculation unit is used for obtaining the temperature of the area of the preset area on the side away from the sound source according to the time difference and the reference temperature.
Optionally, the time analysis unit comprises a phase difference analysis subunit and a time difference analysis subunit, wherein,
the phase difference analysis subunit is used for acquiring a phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave;
and the time difference analysis subunit is used for obtaining the time difference between the detection time and the reference time according to the phase difference.
Optionally, the phase difference analysis subunit is configured to perform a cross-correlation operation on the sound wave information of the test transmission ultrasonic wave and the sound wave information of the reference transmission ultrasonic wave to obtain a phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave.
Optionally, the phase difference analysis subunit is configured to compare a phase difference between each data point in the information of the test transmission ultrasonic wave and a corresponding data point in the information of the reference transmission ultrasonic wave, and determine the phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave according to a difference between phase differences corresponding to data points in a predetermined proportion where the phase difference is the largest.
Optionally, the temperature sensing member comprises a thermocouple.
Optionally, the device further comprises an alarm module, wherein the alarm module is used for sending out an alarm signal when the temperature of the area of the side, away from the sound source, of the predetermined area exceeds a preset temperature range.
Optionally, the ultrasonic wave emitted by the ultrasonic transmission module is a focused pulse ultrasonic wave, and a focal point of the focused pulse ultrasonic wave is located in the predetermined area.
Optionally, the ultrasonic transmitting module and the ultrasonic receiving module are respectively disposed on two opposite sides of the predetermined region.
In the temperature monitoring device provided by the invention, the ultrasonic transmitting module can transmit the test ultrasonic wave, the ultrasonic receiving module receives the test transmission ultrasonic wave generated by the transmission of the test ultrasonic wave by the back tissue, and the propagation speed of the ultrasonic wave in the focal domain tissue changes along with the test transmission ultrasonic wave when the back tissue is at different temperatures, so that the detection time from the transmission of the real-time test ultrasonic wave to the reception of the test transmission ultrasonic wave is influenced. The calculation module can judge the current temperature of the back tissue according to the detection time and the corresponding relation between the detection time and the temperature, so that the temperature of the back tissue is monitored in real time and efficiently in the ultrasonic ablation treatment process.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic diagram of one configuration of a temperature monitoring device provided by the present invention;
FIG. 2 is a schematic diagram of another configuration of a temperature monitoring device provided by the present invention;
FIG. 3 is a schematic diagram of another configuration of a temperature monitoring device provided by the present invention;
fig. 4 is a schematic diagram of another configuration of the temperature monitoring device provided by the present invention.
Description of the reference numerals
10: the ultrasound transmission module 20: ultrasonic receiving module
30: the calculation module 31: reference recording unit
32: time analysis unit 321: phase difference analysis subunit
322: time difference analysis subunit 33: temperature calculating unit
40: temperature detection piece 50: alarm module
Detailed Description
The following detailed description of embodiments of the invention refers to the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating the present invention, are given by way of illustration and explanation only, not limitation.
To solve the above technical problem, as one aspect of the present invention, there is provided a temperature monitoring apparatus, as shown in fig. 1, comprising:
the ultrasonic transmitting module 10, the ultrasonic transmitting module 10 is used for sending test ultrasonic waves to a preset area inside an object;
an ultrasonic receiving module 20, wherein the ultrasonic receiving module 20 is used for receiving the test transmission ultrasonic wave generated by the object at the side opposite to the sound source (namely the ultrasonic transmitting module 10) of the test ultrasonic wave;
a calculating module 30, wherein the calculating module 30 is configured to obtain a temperature of an area (i.e., an area where the back tissue is located) on a side of the predetermined area away from the sound source according to a detection time from the sending of the test ultrasonic wave by the ultrasonic sending module 10 to the receiving of the test transmission ultrasonic wave by the ultrasonic receiving module 20.
In an ultrasonic ablation experiment, the inventors of the present invention found that when the focal region tissue is subjected to the temperature raising treatment (i.e., ultrasonic ablation), the temperature of the back surface tissue increases, the hardness of the back surface tissue changes with the increase in temperature, and the propagation velocity of the ultrasonic wave in the back surface tissue changes, that is, there is a correlation between the propagation velocity of the ultrasonic wave in the back surface tissue and the temperature of the back surface tissue.
It should be noted that, in the present invention, the temperature monitoring device may perform temperature detection on the region (i.e. the region where the back tissue is located) of the predetermined region (i.e. the focal region) on the side away from the sound source after the ultrasound ablation treatment is finished, or may perform real-time temperature detection on the back tissue during the ultrasound ablation treatment, for example, perform one detection on the temperature of the back tissue at the end of each ultrasound ablation treatment round. The ultrasonic wave sent by the ultrasonic sending module is a focused pulse ultrasonic wave, and the focus of the focused pulse ultrasonic wave is positioned in the preset area. The ultrasonic wave transmitted by the ultrasonic transmission module may include pulse information, and the calculation module 30 may accurately obtain the time elapsed from the transmission of the ultrasonic wave to the reception of the transmitted ultrasonic wave according to the pulse information in the transmitted ultrasonic wave.
In each temperature detection process performed by the temperature monitoring device provided by the invention, the ultrasonic transmission module 10 firstly transmits a test ultrasonic wave, and then the ultrasonic receiving module 20 receives a test transmission ultrasonic wave generated by the transmission of the test ultrasonic wave by the back tissue, and when the back tissue is at different temperatures, the propagation speed of the ultrasonic wave in the back tissue changes along with the change of the test transmission ultrasonic wave, thereby influencing the time interval (namely the detection time) between the transmission of the real-time test ultrasonic wave and the reception of the test transmission ultrasonic wave. Therefore, the calculation module 30 can determine the current temperature of the back tissue according to the corresponding relationship between the detection time and the temperature only by acquiring the detection time, so as to accurately monitor the temperature of the back tissue in real time and efficiently during the ultrasonic ablation treatment.
In order to remind the staff in time before the temperature exceeds the back tissue bearing range so as to avoid the damage of the ultrasonic ablation to the back tissue, preferably, as shown in fig. 4, the device further comprises an alarm module 50, wherein the alarm module 50 is used for sending an alarm signal when the temperature of the area of the predetermined area on the side away from the sound source (namely, the area where the back tissue is located) exceeds a preset temperature range.
The type of the alarm signal is not specifically limited, for example, the alarm signal may be a section of alarm audio, or may be a section of alarm audio that is played, or may be a section of alarm audio that controls the lighting component to light up or flash, or may be a section of alarm audio that pops up corresponding alarm information in the monitoring interface of the display screen.
The invention does not specifically limit how the calculation module 30 obtains the detection time, for example, optionally, the calculation module 30 may start to record the acoustic waveform information received by the ultrasonic receiving module 20 by directly using the time when the ultrasonic transmitting module 10 sends the test ultrasonic wave as an origin in each temperature detection process, and the phase of the transmission ultrasonic wave in the waveform information may be used to represent the detection time.
In experimental studies, the inventors also found that there is a certain difference between the detection times (or the phases of the above-mentioned transmitted ultrasonic waves) detected by different patients/treatment sites at the same temperature of the dorsal tissues due to individual differences between patients and differences in physical properties between tissues at different sites.
In order to eliminate the influence of the above individual differences/positional differences on the detection result, as a preferred embodiment of the present invention, as shown in fig. 2, the apparatus further includes a temperature detecting member 40 for detecting a reference temperature of an area on a side of the predetermined area away from the sound source (i.e., an area where the back tissue is located);
the ultrasonic transmission module 10 is also used for transmitting reference ultrasonic waves to a predetermined area inside the object;
the ultrasonic receiving module 20 is further used for receiving a reference transmission ultrasonic wave generated by the object on the side away from the sound source;
the calculation module 30 includes a reference recording unit 31 for recording sound wave information of the reference transmitted ultrasonic wave, which includes a reference time elapsed from the transmission of the reference ultrasonic wave from the ultrasonic transmission module 10 to the reception of the reference transmitted ultrasonic wave by the ultrasonic reception module 20.
In the embodiment of the present invention, before the ultrasonic ablation treatment is started, the temperature detecting element 40 measures the reference temperature (i.e. the initial temperature) of the back surface region (i.e. the region where the back surface tissue is located), the ultrasonic transmitting module 10 sends the reference ultrasonic waves to the back surface region, the ultrasonic receiving module 20 receives the reference transmitted ultrasonic waves transmitted by the back surface region, and the reference recording unit 31 in the calculating module 30 records the reference time measured at the reference temperature, so that when the calculating module 30 obtains the temperature of the back surface tissue, the result can be obtained by jointly calculating the detection time, the reference time measured at the reference temperature of the back surface region, and the reference temperature of the back surface region, so as to eliminate the influence of the individual difference/position difference on the detection result.
The sound wave information may include not only the reference time but also sound wave waveform information and phase information of the reference transmitted ultrasonic wave using the time at which the ultrasonic transmission module 10 transmits the reference ultrasonic wave as an origin.
The invention does not specifically limit how the calculation module 30 corrects the calculation result by using the reference temperature and the reference time, for example, optionally, as shown in fig. 2, the calculation module 30 further includes a time analysis unit 32 and a temperature calculation unit 33, wherein,
the time analysis unit 32 is configured to obtain a time difference between the detection time and the reference time;
the temperature calculating unit 33 is configured to obtain a temperature of an area (i.e., an area where the back tissue is located) of the predetermined area on a side away from the sound source according to the time difference and the reference temperature.
In the present invention, the time analysis unit 32 in the calculation module 30 can directly obtain the time difference between the detection time and the reference time (i.e. the time difference between the time taken by the ultrasound to pass through the back tissue at the reference temperature and the current temperature), and the temperature calculation unit 33 can determine the temperature difference between the current temperature and the reference temperature according to the time difference, so as to obtain the current temperature of the back region through the temperature difference and the reference temperature. Therefore, no matter which state and which part of the tissue are subjected to temperature detection, the temperature monitoring equipment provided by the invention can eliminate the influence of tissue difference on the temperature detection result, thereby improving the detection precision.
It should be noted that the temperature monitoring device provided by the present invention is used for detecting the temperature of the back tissue efficiently during the treatment process, and the temperature detecting element 40 only needs to detect the reference temperature of the back tissue before the treatment, so that the embodiment of the present invention does not require the temperature detecting element 40 to have high detection efficiency, and only needs the detection precision of the temperature detecting element 40 to meet the requirement, for example, to improve the detection precision of the reference temperature, preferably, the temperature detecting element 40 includes a thermocouple.
In order to improve the acquisition accuracy of the time difference, it is preferable that the time difference between the detection time and the reference time is calculated from the phase difference between the test transmitted ultrasonic wave and the reference transmitted ultrasonic wave, for example, as shown in fig. 3, the time analysis unit 32 may include a phase difference analysis subunit 321 and a time difference analysis subunit 322, wherein,
the phase difference analysis subunit 321 is configured to acquire a phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave;
the time difference analysis subunit 322 is configured to obtain a time difference between the detection time and the reference time according to the phase difference.
In a preferred embodiment of the present invention, the phase difference analysis subunit 321 may obtain the phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave directly according to the waveform information of the test transmission ultrasonic wave and the reference transmission ultrasonic wave, and obtain the time difference directly through the phase difference. It is not necessary to obtain the detection time and the reference time corresponding to the received waveform information of the test transmission ultrasonic wave and the reference transmission ultrasonic wave, and then calculate the two time values. Therefore, the calculation steps of the data are reduced, and the precision of obtaining the time difference is improved.
The invention is not particularly limited as to how the phase difference analysis subunit 321 obtains the phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave, and for example, optionally, the phase difference analysis subunit 321 is configured to perform a cross-correlation operation on the sound wave information of the test transmission ultrasonic wave and the sound wave information of the reference transmission ultrasonic wave to obtain the phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave.
When the tissue structure near the back tissue is complex and the acquired transmitted ultrasonic waves are disordered, in order to improve the accuracy of the detected temperature, preferably, the phase difference analysis subunit 321 is configured to compare the magnitude of the phase difference between each data point in the information of the test transmitted ultrasonic wave and the corresponding data point in the information of the reference transmitted ultrasonic wave, and determine the phase difference between the test transmitted ultrasonic wave and the reference transmitted ultrasonic wave according to the difference of the phase differences corresponding to the data points with the maximum phase difference and the predetermined ratio.
Since the temperature rise is more obvious as the distance from the focal region is closer in the ultrasonic ablation treatment, the phase change of the transmission ultrasonic wave generated by the transmission of the back tissue is more obvious than other regions. Therefore, in the present invention, the phase difference analysis subunit 321 performs integrated analysis on only the difference between the phase differences corresponding to the predetermined percentage of data points with the largest phase difference, so as to obtain the temperature of the back tissue by using only the transmission ultrasonic waves generated by the transmission of the back tissue, filter out the waveform data corresponding to the region with insignificant temperature change, and improve the accuracy of detecting the temperature of the back tissue.
The present invention does not specifically limit the structure of the Ultrasonic transmission module 10 and the Ultrasonic reception module 20, for example, at least one of the Ultrasonic transmission module 10 and the Ultrasonic reception module 20 may be an Ultrasonic transducer (Ultrasonic transducer).
The present invention is not particularly limited to the use state of the ultrasonic transmission module 10 and the ultrasonic reception module 20, and for example, the ultrasonic transmission module 10 and the ultrasonic reception module 20 may be respectively disposed on two opposite sides of the predetermined region. Preferably, the ultrasonic transmission module 10, the predetermined region and the ultrasonic reception module 20 are disposed along the same straight line, and when the ultrasonic wave emitted from the ultrasonic transmission module 10 sequentially penetrates through the focal region (i.e., the predetermined region) tissue and the back tissue to generate a transmission ultrasonic wave on the back of the object, the ultrasonic reception module 20 is located exactly on the propagation path of the transmission ultrasonic wave, thereby increasing the signal reception rate of the ultrasonic wave.
It will be understood that the above embodiments are merely exemplary embodiments taken to illustrate the principles of the present invention, which is not limited thereto. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit and substance of the invention, and these modifications and improvements are also considered to be within the scope of the invention.
Claims (10)
1. A temperature monitoring device, characterized in that the device comprises:
an ultrasonic transmission module for transmitting a test ultrasonic wave to a predetermined region inside an object;
an ultrasonic receiving module for receiving a test transmission ultrasonic wave generated by the object on a side away from a sound source of the test ultrasonic wave;
and the calculation module is used for obtaining the temperature of the area of one side, away from the sound source, of the preset area according to the detection time from the test ultrasonic wave sent by the ultrasonic sending module to the test transmission ultrasonic wave received by the ultrasonic receiving module.
2. The temperature monitoring apparatus according to claim 1, characterized in that the apparatus further comprises a temperature detecting member for detecting a reference temperature of an area on a side of the predetermined area facing away from the sound source;
the ultrasonic transmitting module is also used for transmitting reference ultrasonic waves to a preset area inside the object;
the ultrasonic receiving module is also used for receiving reference transmission ultrasonic waves generated by the object on the side away from the sound source;
the calculation module includes a reference recording unit configured to record sound wave information of the reference transmitted ultrasonic wave, the sound wave information including a reference time elapsed from the transmission of the reference ultrasonic wave by the ultrasonic transmission module to the reception of the reference transmitted ultrasonic wave by the ultrasonic reception module.
3. The temperature monitoring device of claim 2, wherein the calculation module further comprises a time analysis unit and a temperature calculation unit, wherein,
the time analysis unit is used for obtaining a time difference between the detection time and the reference time;
the temperature calculation unit is used for obtaining the temperature of the area of the preset area on the side away from the sound source according to the time difference and the reference temperature.
4. The temperature monitoring device according to claim 3, wherein the time analysis unit comprises a phase difference analysis subunit and a time difference analysis subunit, wherein,
the phase difference analysis subunit is used for acquiring a phase difference between the test transmission ultrasonic wave and the reference transmission ultrasonic wave;
and the time difference analysis subunit is used for obtaining the time difference between the detection time and the reference time according to the phase difference.
5. The temperature monitoring apparatus according to claim 4, wherein the phase difference analysis subunit is configured to perform a cross-correlation operation on the sound wave information of the test transmitted ultrasonic wave and the sound wave information of the reference transmitted ultrasonic wave to obtain the phase difference between the test transmitted ultrasonic wave and the reference transmitted ultrasonic wave.
6. The temperature monitoring apparatus according to claim 4, wherein the phase difference analyzing subunit is configured to compare the magnitude of the phase difference between each data point in the information of the test transmitted ultrasonic wave and the corresponding data point in the information of the reference transmitted ultrasonic wave, and determine the phase difference between the test transmitted ultrasonic wave and the reference transmitted ultrasonic wave according to the difference of the phase differences corresponding to a predetermined proportion of the data points where the phase difference is the largest.
7. The temperature monitoring apparatus of any one of claims 2 to 6, wherein the temperature sensing member comprises a thermocouple.
8. The temperature monitoring device according to any one of claims 1 to 6, characterized in that the device further comprises an alarm module for emitting an alarm signal when the temperature of the area on the side of the predetermined area facing away from the sound source exceeds a preset temperature range.
9. The temperature monitoring device according to any one of claims 1 to 6, wherein the ultrasonic wave emitted by the ultrasonic transmission module is a focused pulse ultrasonic wave, and a focal point of the focused pulse ultrasonic wave is located in the predetermined region.
10. The temperature monitoring device according to any one of claims 1 to 6, wherein the ultrasonic transmission module and the ultrasonic reception module are respectively disposed on opposite sides of the predetermined region.
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