CN113092801B - Sample application head of plunger type biochip sample application instrument - Google Patents
Sample application head of plunger type biochip sample application instrument Download PDFInfo
- Publication number
- CN113092801B CN113092801B CN202110395125.9A CN202110395125A CN113092801B CN 113092801 B CN113092801 B CN 113092801B CN 202110395125 A CN202110395125 A CN 202110395125A CN 113092801 B CN113092801 B CN 113092801B
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- liquid
- valve plate
- sample application
- flow distribution
- stator
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- 238000000018 DNA microarray Methods 0.000 title claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 102
- 230000005540 biological transmission Effects 0.000 claims abstract description 26
- 238000007789 sealing Methods 0.000 claims abstract description 19
- 238000005507 spraying Methods 0.000 claims abstract description 15
- 239000007921 spray Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 description 4
- 239000000919 ceramic Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N2001/002—Devices for supplying or distributing samples to an analysing apparatus
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a sample application head of a plunger type biochip sample application instrument, which comprises a transmission shaft, a cylinder body, a plurality of plungers, springs and a stator; the plunger presses against the inner wall of the stator, and the transmission shaft is slidably provided with a valve plate; the power device drives the valve plate to move towards the direction of the flow distribution plate or move in the opposite direction; the plurality of plungers divide the interior of the stator into a plurality of sealing spaces, and when the transmission shaft rotates, the size of the sealing spaces is continuously changed to realize liquid suction from the liquid inlet and liquid ejection from the liquid outlet; the sealing space is communicated with the flow distribution disc and the valve plate; when the sealed space absorbs liquid, the power device drives the valve plate to slide back to the direction of the valve plate, so that a capacity-expanding liquid storage structure is formed; when the sealed space sprays liquid, the power device drives the valve plate to slide towards the direction of the flow distribution plate, so that a pressurized liquid spraying structure is formed. The invention can improve the upper limit of the liquid storage in the sealed space by controlling the movement and the position of the valve plate, can increase the pressure and the speed of liquid spraying, and meets the requirement of more biochip sample application points.
Description
Technical Field
The invention relates to a sample application head of a sample application instrument, in particular to a sample application head of a plunger type biochip sample application instrument.
Background
The sample application heads adopted by the sample application instrument in the market at present are in a piezoelectric spray head mode and a chemical sensor mode. The piezoelectric ceramic sample application head mainly comprises double sample application, wheel array type, array type and the like. The working principle of the piezoelectricity spray head is to utilize the inverse piezoelectric effect of the piezoelectricity ceramic, namely the piezoelectricity ceramic can deform or bend under the action of voltage, so as to spray out liquid drops with fixed volume. However, the piezoelectric nozzle with the structure has small ejection pressure and low speed, can only meet the requirements of about 30 biochip spotting points, and the volume of liquid stored once is fixed, so that the volume of the stored liquid can not be increased when the liquid is absorbed, and the liquid can be ejected rapidly when the liquid is ejected.
Disclosure of Invention
The invention aims to solve the problems and provide a sample application head of a plunger type biochip sample application instrument. The sample application head can increase the volume of stored liquid during liquid suction, and improve the pressure and speed of spraying during liquid spraying, so that the pressure, speed and volume of the sprayed liquid are realized, and the requirements of more biochip sample application points are met.
The aim of the invention can be achieved by adopting the following technical scheme:
the sample application head of the plunger type biochip sample application instrument comprises a transmission shaft, a cylinder body fixedly arranged on the transmission shaft, a plurality of plungers slidably arranged in the radial direction of the cylinder body, a spring arranged between the plungers and the cylinder body and used for ejecting the plungers outwards, and a stator sleeved outside the cylinder body; the plunger presses against the inner wall of the stator, and the plunger is connected with the inner wall of the stator in a sealing way; a flow distribution plate is fixedly arranged on the transmission shaft, a valve plate is slidably arranged on the transmission shaft, and the flow distribution plate and the valve plate are arranged in the stator; the power device drives the valve plate to move towards the direction of the flow distribution plate or move in the opposite direction; the stator is provided with a liquid inlet and a liquid outlet, the inside of the stator is divided into a plurality of sealing spaces by a plurality of plungers, and when the transmission shaft drives the cylinder body and the plungers to rotate, the sealing spaces continuously change in size to realize liquid suction from the liquid inlet and liquid ejection from the liquid outlet; the sealing space is communicated with the flow distribution plate and the valve plate; when the sealed space absorbs liquid, the power device drives the valve plate to slide back to the direction of the valve plate, so that a capacity-expanding liquid storage structure is formed; when the sealed space sprays liquid, the power device drives the valve plate to slide towards the direction of the flow distribution plate, so that a pressurized liquid spraying structure is formed.
As a preferable scheme, the flow distribution plate is provided with a groove, and when the sealed space sprays liquid, the power device drives the flow distribution plate to slide towards the flow distribution plate and be sleeved in the groove.
As a preferable scheme, the power device comprises a sliding rail fixedly arranged on a transmission shaft, a sliding block which is slidably sleeved on the sliding rail and fixedly connected with the valve plate, a connecting rod mechanism connected with the sliding block, and a motor for driving the sliding block to slide through the connecting rod mechanism.
As a preferable mode, the radial section of the cylinder body is elliptical.
As a preferable scheme, the liquid inlet and the liquid outlet are respectively provided with a first one-way valve and a second one-way valve, when the sealed space absorbs liquid, the first one-way valve is opened, and the second one-way valve is closed; when the sealed space sprays liquid, the second one-way valve is opened, and the first one-way valve is closed.
As a preferable scheme, the two ends of the transmission shaft are rotatably arranged in the stator through bearings.
The implementation of the invention has the following beneficial effects:
1. when the sealed space absorbs liquid, the power device drives the valve plate to slide back to the direction of the flow distribution plate to form a capacity-expansion liquid storage structure, so that more liquid enters between the sealed space and the valve plate through the liquid inlet, and the volume of liquid storage is increased; when the sealed space sprays liquid, the power device drives the valve plate to slide towards the direction of the flow distribution plate, so that the valve plate extrudes the liquid, the pressure and the flow velocity of the liquid sprayed from the liquid outlet are increased, and a pressurized liquid spraying structure is formed. The structure ensures that the upper limit of the liquid storage in the sealed space is improved by controlling the movement and the position of the valve plate, and the pressure and the speed of liquid spraying can be increased, thereby meeting the requirements of more biochip sample application points.
2. According to the invention, the grooves are formed in the flow distribution plate, so that the grooves have liquid storage capacity, the upper limit of liquid storage in a sealed space is improved, and the movement distance of the flow distribution plate is increased, so that the pressure and speed of liquid spraying are improved, and further, the requirements of more biochip sample application points can be met.
3. The radial section of the cylinder body is elliptical, so that when the transmission shaft drives the cylinder body to rotate, the size of the sealing space is in the process of continuously changing, namely the sealing space is in the process of changing from large to small to large, thereby realizing the function of liquid suction, liquid spraying and liquid suction circulation.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a radial cross-sectional view of the print head of the plunger biochip print meter of the invention.
Fig. 2 is a schematic view of the structure of the print head of the plunger biochip print apparatus after the stator is removed.
FIG. 3 is a schematic diagram showing the connection structure of the split flow plate and the port flow plate of the print head of the plunger type biochip print tester according to the present invention.
FIG. 4 is a schematic diagram of the power unit of the print head of the plunger biochip spotter of the invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Examples
Referring to fig. 1 to 4, the present embodiment relates to a print head of a plunger type biochip print apparatus, which comprises a transmission shaft 1, a cylinder 2 fixedly mounted on the transmission shaft 1, a plurality of plungers 3 slidably disposed in a radial direction of the cylinder 2, a spring (not shown) disposed between the plungers 3 and the cylinder 2 and having an outward ejection of the plungers 3, and a stator 4 sleeved outside the cylinder 2; the plunger 3 presses against the inner wall of the stator 4, and the plunger 3 is connected with the inner wall of the stator 4 in a sealing way; a split flow disc 5 is fixedly arranged on the transmission shaft 1, a valve plate 6 is slidably arranged on the transmission shaft 1, and the split flow disc 5 and the valve plate 6 are arranged in the stator 4; the power device 7 drives the valve plate 6 to move towards the direction of the flow distribution plate 5 or move reversely; the stator 4 is provided with a liquid inlet 41 and a liquid outlet 42, the plurality of plungers 3 divide the interior of the stator 4 into a plurality of sealing spaces 43, and when the transmission shaft 1 drives the cylinder body 2 and the plungers 3 to rotate, the size of the sealing spaces 43 is continuously changed to realize liquid suction from the liquid inlet 41 and liquid ejection from the liquid outlet 42; the sealing space 43 is communicated with the flow distribution disc 5 and the valve plate 6; when the sealed space 43 absorbs liquid, the power device 7 drives the valve plate 6 to slide back to the direction of the flow distribution plate 5 to form a capacity-expanding liquid storage structure, so that more liquid enters between the sealed space 43 and the valve plate 6 through the liquid inlet 41, and the volume of liquid storage is increased; when the sealed space 43 sprays liquid, the power device 7 drives the valve plate 6 to slide towards the direction of the flow distribution plate 5, so that the valve plate 6 extrudes the liquid, the pressure and the flow velocity of the liquid sprayed from the liquid outlet 42 are increased, and a pressurized liquid spraying structure is formed. The structure can improve the upper limit of the liquid storage in the sealed space 43 by controlling the movement and the position of the valve plate 6, and can increase the pressure and the speed of liquid spraying, thereby meeting the requirements of more biochip sample application points.
As shown in fig. 2, the diverter disc 5 is provided with a groove 51, and when the sealed space 43 sprays liquid, the power device 7 drives the valve plate 6 to slide towards the diverter disc 5 and is sleeved in the groove 51. By providing the grooves 51 on the split plate 5, the grooves 51 can have liquid storage capacity, the upper limit of the liquid storage in the sealed space 43 is improved, and the movement distance of the valve plate 6 is increased, so that the pressure and speed of liquid spraying are improved, and further the demands of more biochip sample application points can be met.
As shown in fig. 4, the power device 7 includes a sliding rail 71 fixedly mounted on the transmission shaft 1, a sliding block 72 slidably sleeved on the sliding rail 71 and fixedly connected with the valve plate 6, a link mechanism 73 connected with the sliding block 72, and a motor 74 driving the sliding block 72 to slide through the link mechanism 73. The linkage 73 includes a first link 731 and a second link 732, and the motor 74 is hinged to the slider 72 via the first link 731 and the second link 732. When in operation, the motor 74 drives the first connecting rod and the second connecting rod 732 to swing, and then drives the slider 72 to slide on the sliding rail 71. The forward and reverse sliding of the slider 72 is controlled by controlling the forward and reverse rotation of the motor 74, respectively, so as to achieve the purpose of controlling the sliding direction of the valve plate 6.
The radial cross section of the cylinder body 2 is elliptical. Because the radial section of the cylinder body 2 is elliptical, when the transmission shaft 1 drives the cylinder body 2 to rotate, the size of the sealing space 43 is in the process of continuously changing, namely the sealing space 43 is in the process of changing from large to small to large, so that the function of liquid suction, liquid spraying and liquid suction circulation can be realized.
The liquid inlet 41 and the liquid outlet 42 are respectively provided with a first one-way valve 8 and a second one-way valve 9. The inlet of the first one-way valve 8 is connected with the liquid storage tank. When the sealed space 43 absorbs liquid, namely, when the sealed space 43 gradually becomes larger, the first one-way valve 8 is opened, and the second one-way valve 9 is closed, so that liquid in the liquid storage tank enters the sealed space 43 through the first one-way valve 8; when the sealed space 43 sprays liquid, that is, when the sealed space 43 gradually becomes smaller, the second one-way valve 9 is opened, and the first one-way valve 8 is closed, so that the liquid in the sealed space 43 is extruded from the liquid outlet 42.
In order to reduce the friction force of the rotation of the transmission shaft 1 and improve the stability, the two ends of the transmission shaft 1 are rotatably arranged in the stator 4 through bearings 10.
The above disclosure is only a preferred embodiment of the present invention, and it is needless to say that the scope of the invention is not limited thereto, and therefore, the equivalent changes according to the claims of the present invention still fall within the scope of the present invention.
Claims (6)
1. The sample application head of the plunger type biochip sample application instrument is characterized by comprising a transmission shaft, a cylinder body fixedly arranged on the transmission shaft, a plurality of plungers slidably arranged in the radial direction of the cylinder body, a spring arranged between the plungers and the cylinder body and used for ejecting the plungers outwards, and a stator sleeved outside the cylinder body; the plunger presses against the inner wall of the stator, and the plunger is connected with the inner wall of the stator in a sealing way; a flow distribution plate is fixedly arranged on the transmission shaft, a valve plate is slidably arranged on the transmission shaft, and the flow distribution plate and the valve plate are arranged in the stator; the power device drives the valve plate to move towards the direction of the flow distribution plate or move in the opposite direction; the stator is provided with a liquid inlet and a liquid outlet, the inside of the stator is divided into a plurality of sealing spaces by a plurality of plungers, and when the transmission shaft drives the cylinder body and the plungers to rotate, the sealing spaces continuously change in size to realize liquid suction from the liquid inlet and liquid ejection from the liquid outlet; the sealing space is communicated with the flow distribution plate and the valve plate; when the sealed space absorbs liquid, the power device drives the valve plate to slide back to the direction of the valve plate, so that a capacity-expanding liquid storage structure is formed; when the sealed space sprays liquid, the power device drives the valve plate to slide towards the direction of the flow distribution plate, so that a pressurized liquid spraying structure is formed.
2. The sample application head of the plunger type biochip sample application instrument according to claim 1, wherein the flow distribution plate is provided with a groove, and the power device drives the flow distribution plate to slide towards the flow distribution plate and be sleeved in the groove when the sealed space is used for spraying liquid.
3. The print head of a plunger biochip spotting apparatus according to claim 1, wherein the power device comprises a slide rail fixedly mounted on the transmission shaft, a slide block slidably sleeved on the slide rail and fixedly connected with the valve plate, a link mechanism connected with the slide block, and a motor driving the slide block to slide through the link mechanism.
4. The print head of a plunger biochip print meter according to claim 1, wherein the radial cross section of the cylinder is elliptical in shape.
5. The sample application head of the plunger type biochip sample application instrument according to claim 1, wherein the liquid inlet and the liquid outlet are respectively provided with a first one-way valve and a second one-way valve, and when the sealed space absorbs liquid, the first one-way valve is opened, and the second one-way valve is closed; when the sealed space sprays liquid, the second one-way valve is opened, and the first one-way valve is closed.
6. The print head of a plunger biochip print instrument according to claim 1, wherein the two ends of the drive shaft are rotatably mounted in the stator via bearings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110395125.9A CN113092801B (en) | 2021-04-13 | 2021-04-13 | Sample application head of plunger type biochip sample application instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110395125.9A CN113092801B (en) | 2021-04-13 | 2021-04-13 | Sample application head of plunger type biochip sample application instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113092801A CN113092801A (en) | 2021-07-09 |
| CN113092801B true CN113092801B (en) | 2024-04-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110395125.9A Active CN113092801B (en) | 2021-04-13 | 2021-04-13 | Sample application head of plunger type biochip sample application instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113092801B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2218265Y (en) * | 1995-03-06 | 1996-01-24 | 郭淦生 | Pump of water supplying apparatus |
| CN103423150A (en) * | 2012-04-23 | 2013-12-04 | 贾利春 | Rotor fluid mechanical transfiguration mechanism |
| CN203847338U (en) * | 2014-04-18 | 2014-09-24 | 阜新嘉斯乐液压有限公司 | Low-power disc flow-distributing-plate-type radial plunger pump |
| CN204283775U (en) * | 2014-11-28 | 2015-04-22 | 北京创新通恒科技有限公司 | A kind of many pump heads radial plunger pump |
| CN104948409A (en) * | 2015-07-01 | 2015-09-30 | 张坚 | Quantified and axial plunger pump |
| CN105818389A (en) * | 2016-05-07 | 2016-08-03 | 浙江大学 | Self-sucking biological 3D printing nozzle device and method thereof |
| CN109209805A (en) * | 2018-11-09 | 2019-01-15 | 力源液压（苏州）有限公司 | A kind of variable piston pump port plate automatic regulating apparatus |
| CN110360095A (en) * | 2019-08-20 | 2019-10-22 | 四川航天烽火伺服控制技术有限公司 | Plunger assembly and plunger pump with the component |
-
2021
- 2021-04-13 CN CN202110395125.9A patent/CN113092801B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2218265Y (en) * | 1995-03-06 | 1996-01-24 | 郭淦生 | Pump of water supplying apparatus |
| CN103423150A (en) * | 2012-04-23 | 2013-12-04 | 贾利春 | Rotor fluid mechanical transfiguration mechanism |
| CN103452836A (en) * | 2012-04-23 | 2013-12-18 | 贾利春 | Capacity varying mechanism of rotor fluid machine |
| CN203847338U (en) * | 2014-04-18 | 2014-09-24 | 阜新嘉斯乐液压有限公司 | Low-power disc flow-distributing-plate-type radial plunger pump |
| CN204283775U (en) * | 2014-11-28 | 2015-04-22 | 北京创新通恒科技有限公司 | A kind of many pump heads radial plunger pump |
| CN104948409A (en) * | 2015-07-01 | 2015-09-30 | 张坚 | Quantified and axial plunger pump |
| CN105818389A (en) * | 2016-05-07 | 2016-08-03 | 浙江大学 | Self-sucking biological 3D printing nozzle device and method thereof |
| CN109209805A (en) * | 2018-11-09 | 2019-01-15 | 力源液压（苏州）有限公司 | A kind of variable piston pump port plate automatic regulating apparatus |
| CN110360095A (en) * | 2019-08-20 | 2019-10-22 | 四川航天烽火伺服控制技术有限公司 | Plunger assembly and plunger pump with the component |
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|---|---|
| CN113092801A (en) | 2021-07-09 |
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