CN113082119A - Antibacterial agent for resisting escherichia coli and preparation method thereof - Google Patents
Antibacterial agent for resisting escherichia coli and preparation method thereof Download PDFInfo
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- CN113082119A CN113082119A CN202110444739.1A CN202110444739A CN113082119A CN 113082119 A CN113082119 A CN 113082119A CN 202110444739 A CN202110444739 A CN 202110444739A CN 113082119 A CN113082119 A CN 113082119A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/022—Refining
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the technical field of antibacterial agent preparation, and particularly relates to an antibacterial agent for resisting escherichia coli and a preparation method thereof, wherein the antibacterial agent for resisting escherichia coli comprises the following components: 20-30 parts of oregano essential oil; 25-35 parts of cinnamon essential oil; 15-25 parts of thyme essential oil; 10-15 parts of tea tree essential oil; 3-5 parts of custard apple juice; can effectively eliminate escherichia coli, and the escherichia coli can not generate drug resistance; the custard apple juice is added into the raw materials, so that the antibacterial agent has certain sweetness and is convenient for a patient to take; through the matching use of the base, the juicing barrel, the L-shaped supporting plate, the air cylinder, the push rod, the push plate, the cutter, the cylindrical block, the annular plate, the rectangular plate, the positioning rod, the rack, the first cavity, the threaded rod, the gear, the sliding groove, the second cavity, the first plate, the inserted rod, the inserting groove and the air bag, the full crushing of the custard apple is realized, and the juicing efficiency of the custard apple can be improved.
Description
Technical Field
The invention belongs to the technical field of antibacterial agent preparation, and particularly relates to an antibacterial agent for resisting escherichia coli and a preparation method thereof.
Background
Escherichia coli (also called Escherichia coli) is a conditional pathogenic bacterium and can cause gastrointestinal tract infection or urinary tract infection of various local tissues and organs of human and various animals under certain conditions.
Some technical schemes related to the preparation of antibacterial agents also appear in the prior art, for example, a chinese patent with application number CN202011145395.6 discloses a botanical broad-spectrum antibacterial agent and a preparation method thereof, comprising the following components: 8-10 g of Gentiana lutea aqueous extract, 8-9 g of chickweed aqueous extract, 3-5 g of stachys japonica aqueous extract, 2-4 g of Dabaihua sanguisorba aqueous extract, 2-3 g of Shihai pepper aqueous extract and 1-2 g of Tephrodia Tephrodioides aqueous extract; however, the antibacterial agent is bitter and astringent when being taken orally, so that the patient can not swallow the antibacterial agent easily, and the antibacterial agent is difficult to take for a long time.
To this end, the present invention provides an antibacterial agent for combating escherichia coli and a method for preparing the same.
Disclosure of Invention
The invention provides an antibacterial agent for resisting escherichia coli and a preparation method thereof, aiming at making up for the defects of the prior art and solving the problem that the existing oral antibacterial agent is bitter and astringent when being orally taken, so that a patient is difficult to swallow, and the patient is difficult to take for a long time.
The technical scheme adopted by the invention for solving the technical problems is as follows: the invention relates to an antibacterial agent for resisting escherichia coli, which consists of the following components:
20-30 parts of oregano essential oil;
25-35 parts of cinnamon essential oil;
15-25 parts of thyme essential oil;
10-15 parts of tea tree essential oil;
3-5 parts of custard apple juice.
When the oregano essential oil, the cinnamon essential oil, the thyme essential oil and the tea tree essential oil are used as the antibacterial agents, the oregano essential oil, the cinnamon essential oil, the thyme essential oil and the tea tree essential oil can effectively eliminate escherichia coli, can not cause drug resistance of the escherichia coli, and can not cause harm to human bodies; the custard apple juice is added into the raw materials, so that the antibacterial agent has certain sweetness, a patient does not feel bitter when taking the antibacterial agent orally, the custard apple juice is easier for the patient to swallow, the long-term taking of the patient is convenient to realize, and meanwhile, the custard apple has the effect of reducing blood sugar, so that the phenomenon of overhigh blood sugar of the patient after taking the custard apple for a long time can be avoided.
Further, the custard apple juice comprises the following components in parts by weight:
10-15 parts of carbohydrate;
7-9 parts of vitamin C;
5-8 parts of protein.
A method for producing an antibacterial agent against escherichia coli, which is suitable for use as the antibacterial agent against escherichia coli described in any one of the above, comprising the steps of:
s1: respectively placing origanum vulgaris, cinnamon, thyme and tea tree into an essential oil extraction device, and adjusting the pressure and temperature inside the extraction device to make the extraction process be carried out under the pressure of 0.5-1.5MPa and the temperature of 20-60 ℃ to respectively obtain respective essential oil extracting solutions;
s2: firstly, extracting juice from custard apple by using a juice extracting device, then putting the juice into a volumetric flask, standing for 20-30min, and taking out supernatant to obtain custard apple juice;
s3: pouring the oregano essential oil, cinnamon essential oil, thyme essential oil and tea tree essential oil obtained in the step S1 and the custard juice obtained in the step S2 into a reaction kettle, uniformly stirring by using a stirring rod at the stirring speed of 60r/min and the stirring temperature of 40-50 ℃, and then standing for 10min to complete the preparation of the antibacterial agent.
The juicing equipment of S2 comprises a base; the top of the base is fixedly connected with a juicing barrel; the top of the base is fixedly connected with an L-shaped supporting plate; a juicing unit is arranged inside the juicing barrel; the bottom of the juicing barrel is fixedly connected with a discharge pipe; the juicing unit comprises an air cylinder, a push rod, a push plate and a cutter; the cylinder is fixedly connected to the top of the L-shaped supporting plate; the push rod is fixedly connected with the output end of the air cylinder; the push plate is fixedly connected to the bottom end of the push rod; the bottom of the push plate is fixedly connected with a cylindrical block; the cutter is fixedly connected to the bottom of the cylindrical block; when the device works, firstly, the custard apple is placed into the juice extraction barrel, then the air cylinder is started, the air cylinder drives the push plate to move downwards through the push rod, so that the cutter starts to cut the custard apple, and the push plate also extrudes the custard apple, thereby realizing the crushing and juice extraction of the custard apple.
Further, an annular plate is fixedly connected to the periphery of the cylindrical block; the bottom of the annular plate is connected with a rectangular plate in a sliding manner; when the juicer works, after the air cylinder drives the cutter to move downwards through the push rod and the push plate, the bottom of the rectangular plate is lower than the bottom of the cutter, so that the cutter is ensured not to contact with the inner side wall of the bottom of the juicing barrel, and the cutter is prevented from damaging the inner side wall of the bottom of the juicing barrel; wherein the annular plate also has the function of squeezing the custard apple.
Furthermore, a positioning rod is connected inside the cutter in a sliding manner; the bottom end of the positioning rod is arranged in a pointed cone shape, and the top end of the positioning rod is fixedly connected with a rack; a first cavity is formed in the cylindrical block; the rack is connected with the inner wall of the first cavity through a spring; a threaded rod is rotationally connected in the first cavity; the periphery of the threaded rod is sleeved with a gear, and the gear is fixedly connected with the threaded rod; the gear and the rack are mutually meshed; the bottom of the annular plate is provided with a pair of sliding chutes; two ends of the threaded rod are arranged in the sliding groove; the rectangular plate is sleeved on the threaded rod and is rotatably connected with the threaded rod; when the juice extractor works, after the cutter moves downwards, because the elastic coefficient of the spring at the top of the rack is larger, after the positioning rod is contacted with the custard fruit, the positioning rod is inserted into the custard fruit and cannot cause the spring to generate compression deformation, after the positioning rod is contacted with the inner side wall of the bottom of the juice extracting barrel, the positioning rod moves downwards along with the cutter, the spring generates compression deformation, the gear and the gear are mutually meshed, the threaded rod is rotated, the rectangular plates slide in the sliding chute, and the two rectangular plates simultaneously move towards the center direction of the cutter due to the opposite rotation directions of the threads at the two ends of the threaded rod, so that the custard fruit between the two rectangular plates is extruded, the custard fruit is extracted into juice, and the juice extractor is favorable for fully extracting juice in the custard fruit; wherein the positioning rod has the function of fixing the custard apple, so as to prevent the custard apple from sliding in the cutting and extruding processes.
Further, a second cavity is formed in the rectangular plate; a first plate is connected in the second cavity in a sliding manner; the side wall of the first plate is fixedly connected with an inserting rod, and the other end of the inserting rod is arranged in a pointed cone shape; a slot is formed in one side, close to the cutter, of the rectangular plate; the inserted bar is connected with the slot in a sliding manner; the part of the rectangular plate, which is positioned in the sliding groove, is fixedly connected with an air bag, and the air bag is communicated with the rodless cavity of the second cavity; when the device works, after the rectangular plate moves towards the center of the cutter, the air bag generates compression deformation, air in the air bag enters the rodless cavity of the second cavity, the first plate is pushed to move towards the center of the cutter, and the inserted rod is further separated from the slot, so that the custard apple is further squeezed, the custard apple is fully squeezed, and the juice in the custard apple is fully squeezed.
Furthermore, a groove is formed in the surface of the inserted link; the inner wall of the groove is hinged with a connecting rod, and the other end of the connecting rod is connected in the groove through a spring; when the device works, when the inserted rod gradually leaves the slot, the connecting rod in the groove rotates around the hinge point under the action of the elastic force of the spring, and the connecting rod is inserted into the custard apple to further accelerate the crushing of the custard apple and then extrude the custard apple by matching with the rectangular plate, thereby being beneficial to fully extracting the juice in the custard apple.
Further, a plurality of crushing teeth are fixedly connected to the outer wall of the connecting rod; when the device works, after the inserting rod leaves the inserting groove, the connecting rod leaves the groove and is inserted into the custard apple, and the crushing teeth also extrude the custard apple and insert the custard apple, so that the crushing efficiency of the custard apple is improved, and the full extraction of the juice in the custard apple is facilitated.
Further, a plurality of sharp teeth are fixedly connected to the surface of the crushing teeth; a second plate is connected between the sharp teeth and the sharp teeth in a sliding manner; a straight rod is fixedly connected to one side of the second plate close to the crushing teeth; the straight rod penetrates through the crushing teeth and is in sliding connection with the crushing teeth; the end part of the straight rod is in a pointed cone shape; when the device works, after the crushing teeth are inserted into the custard apple, the pointed teeth are also inserted into the custard apple, and the second plate between the pointed teeth and the pointed teeth begins to slide due to the extrusion of the custard apple, so that the straight rods slide in the crushing teeth and are simultaneously inserted into the custard apple near the crushing teeth, so that the custard apple between the crushing teeth and the crushing teeth is crushed, and the inside juice of the custard apple is fully squeezed.
Furthermore, a baffle plate is fixedly connected to the side wall of the rectangular plate in the sliding groove; the inner wall of the sliding chute is provided with a guide groove at the corresponding position of the baffle; the baffle is connected with the guide groove in a sliding manner; when the device works, the baffle plate slides left and right along with the rectangular plate, the baffle plate is inserted into the guide groove, and the opening of the sliding groove is always in a sealing state, so that the custard pulp is prevented from entering the sliding groove, the threads on the surface of the threaded rod cannot be damaged due to the contamination of the threads by the custard pulp, and the rectangular plate can normally slide in the sliding groove, thereby realizing the extrusion of custard fruits.
The invention has the following beneficial effects:
1. according to the antibacterial agent for resisting escherichia coli and the preparation method thereof, the antibacterial agent can effectively eliminate escherichia coli, does not enable the escherichia coli to generate drug resistance, and does not harm human bodies; the custard apple juice is added into the raw materials, so that the antibacterial agent has certain sweetness, a patient does not feel bitter when taking the antibacterial agent orally, the custard apple juice is easier for the patient to swallow, the long-term taking of the patient is convenient to realize, and meanwhile, the custard apple has the effect of reducing blood sugar, so that the phenomenon of overhigh blood sugar of the patient after taking the custard apple for a long time can be avoided.
2. According to the antibacterial agent for resisting escherichia coli and the preparation method thereof, the air cylinder, the push rod, the push plate, the cutter, the cylindrical block, the annular plate, the rectangular plate, the positioning rod, the rack, the first cavity, the threaded rod, the gear and the sliding groove are matched for use, the custard apple can be cut up, and the custard apple can be extruded from multiple directions, so that the full extraction of juice in the custard apple can be realized.
3. According to the antibacterial agent for resisting escherichia coli and the preparation method thereof, the insertion rod is inserted into the custard apple through the matching use of the cavity II, the plate I, the insertion rod, the insertion slot and the air bag, so that the custard apple is further crushed and extruded, and the full extraction of the juice in the custard apple is facilitated.
Drawings
The invention will be further explained with reference to the drawings.
FIG. 1 is a flow chart of a method of the present invention;
FIG. 2 is a perspective view of the present invention;
FIG. 3 is a partial cross-sectional view of the present invention;
FIG. 4 is an enlarged view of a portion of FIG. 3 at A;
FIG. 5 is a partial enlarged view of FIG. 4 at B;
FIG. 6 is a partial cross-sectional view of the bayonet of the present invention;
FIG. 7 is a structural view of a connecting rod in the present invention;
FIG. 8 is a cross-sectional view of a crushing tooth according to the present invention;
FIG. 9 is an enlarged view of a portion of FIG. 8 at C;
in the figure: 1. a base; 2. a juicing barrel; 21. a discharge pipe; 3. an L-shaped support plate; 41. a cylinder; 42. a push rod; 43. pushing the plate; 44. a cutter; 45. a cylindrical block; 51. an annular plate; 52. a rectangular plate; 61. positioning a rod; 62. a rack; 63. a first cavity; 64. a threaded rod; 65. a gear; 66. a chute; 71. a cavity II; 72. a first board; 73. inserting a rod; 74. a slot; 75. an air bag; 81. a groove; 82. a connecting rod; 9. crushing teeth; 91. pointed teeth; 92. a second plate; 93. a straight rod; 10. a baffle plate; 11. a guide groove.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1
An antibacterial agent for resisting escherichia coli comprises the following components in parts by weight: 20 parts of oregano essential oil; 25 parts of cinnamon essential oil; 15 parts of thyme essential oil; 10 parts of tea tree essential oil; sakyamuni fruit juice 3 parts.
Selecting 50 mice with the same body health state, ensuring that the mice are infected by escherichia coli to cause acute diarrhea, injecting the same amount of the antibacterial agent into each mouse (twice a day, once in the morning and at night), continuously injecting for 3 days, observing the diarrhea condition of the mice, extracting blood of the mice, and detecting the blood sugar content in the mice.
Example 2
An antibacterial agent for resisting escherichia coli comprises the following components in parts by weight: 25 parts of oregano essential oil; 30 parts of cinnamon essential oil; 20 parts of thyme essential oil; 13 parts of tea tree essential oil; sakyamuni fruit juice 4 parts.
Selecting 50 mice with the same body health state, ensuring that the mice are infected by escherichia coli to cause acute diarrhea, injecting the same amount of the antibacterial agent into each mouse (twice a day, once in the morning and at night), continuously injecting for 3 days, observing the diarrhea condition of the mice, extracting blood of the mice, and detecting the blood sugar content in the mice.
Example 3
An antibacterial agent for resisting escherichia coli comprises the following components in parts by weight: 30 parts of oregano essential oil; 35 parts of cinnamon essential oil; 25 parts of thyme essential oil; 15 parts of tea tree essential oil; sakyamuni fruit juice 5 parts.
Selecting 50 mice with the same body health state, ensuring that the mice are infected by escherichia coli to cause acute diarrhea, injecting the same amount of the antibacterial agent into each mouse (twice a day, once in the morning and at night), continuously injecting for 3 days, observing the diarrhea condition of the mice, extracting blood of the mice, and detecting the blood sugar content in the mice.
| Frequency of diarrhea | Blood sugar content | |
| Example 1 | 4 | 2.1 mmol/L |
| Example 2 | 3 | 2.0 mmol/L |
| Example 3 | 2 | 1.9 mmol/L |
As can be seen from examples 1 to 3, the antibacterial agent against Escherichia coli of the present invention can effectively destroy Escherichia coli and at the same time, can reduce the blood sugar level in mice.
As shown in fig. 1 to 9, a method for preparing an antibacterial agent against escherichia coli, which is suitable for use in any one of the above antibacterial agents against escherichia coli, comprising the steps of:
s1: respectively placing origanum vulgaris, cinnamon, thyme and tea tree into an essential oil extraction device, and adjusting the pressure and temperature inside the extraction device to make the extraction process be carried out under the pressure of 0.5-1.5MPa and the temperature of 20-60 ℃ to respectively obtain respective essential oil extracting solutions;
s2: firstly, extracting juice from custard apple by using a juice extracting device, then putting the juice into a volumetric flask, standing for 20-30min, and taking out supernatant to obtain custard apple juice;
s3: pouring the oregano essential oil, cinnamon essential oil, thyme essential oil and tea tree essential oil obtained in the step S1 and the custard juice obtained in the step S2 into a reaction kettle, uniformly stirring by using a stirring rod at the stirring speed of 60r/min and the stirring temperature of 40-50 ℃, and then standing for 10min to complete the preparation of the antibacterial agent.
The juicing equipment of S2 comprises a base 1; the top of the base 1 is fixedly connected with a juicing barrel 2; the top of the base 1 is fixedly connected with an L-shaped supporting plate 3; a juicing unit is arranged inside the juicing barrel 2; a discharge pipe 21 is fixedly connected to the bottom of the juicing barrel 2; the juicing unit comprises a cylinder 41, a push rod 42, a push plate 43 and a cutter 44; the cylinder 41 is fixedly connected to the top of the L-shaped support plate 3; the push rod 42 is fixedly connected with the output end of the air cylinder 41; the push plate 43 is fixedly connected with the bottom end of the push rod 42; the bottom of the push plate 43 is fixedly connected with a cylindrical block 45; the cutter 44 is fixedly connected to the bottom of the cylindrical block 45; when the device works, firstly, the custard apple is put into the juice extracting barrel 2, then the air cylinder 41 is started, the air cylinder 41 drives the push plate 43 to move downwards through the push rod 42, the cutter 44 starts to cut the custard apple, the push plate 43 also extrudes the custard apple, and accordingly, the custard apple is crushed and juice extracted
As an embodiment of the present invention, an annular plate 51 is fixed to the outer periphery of the cylindrical block 45; the bottom of the annular plate 51 is connected with a rectangular plate 52 in a sliding manner; when the juicer works, after the air cylinder 41 drives the cutter 44 to move downwards through the push rod 42 and the push plate 43, the bottom of the rectangular plate 52 is lower than the bottom of the cutter 44, so that the cutter 44 is ensured not to contact with the inner side wall of the bottom of the juicing barrel 2, and the cutter 44 is prevented from damaging the inner side wall of the bottom of the juicing barrel 2; wherein the annular plate 51 also has the function of pressing the custard apple.
In one embodiment of the present invention, a positioning rod 61 is slidably connected inside the cutting knife 44; the bottom end of the positioning rod 61 is arranged in a pointed cone shape, and the top end is fixedly connected with a rack 62; a first cavity 63 is formed in the cylindrical block 45; the rack 62 is connected with the inner wall of the first cavity 63 through a spring; a threaded rod 64 is rotatably connected in the first cavity 63; a gear 65 is sleeved on the periphery of the threaded rod 64, and the gear 65 is fixedly connected with the threaded rod 64; the gear 65 and the rack 62 are meshed with each other; the bottom of the annular plate 51 is provided with a pair of sliding grooves 66; two ends of the threaded rod 64 are arranged in the sliding grooves 66; the rectangular plate 52 is sleeved on the threaded rod 64, and the rectangular plate 52 is rotatably connected with the threaded rod 64; when the juice extractor works, after the cutter 44 moves downwards, because the elastic coefficient of the spring at the top of the rack 62 is larger, after the positioning rod 61 is contacted with the custard fruit, the positioning rod 61 is inserted into the custard fruit and the spring cannot generate compression deformation, after the positioning rod 61 is contacted with the inner side wall of the bottom of the juice extracting barrel 2, the cutter 44 moves downwards continuously, the spring generates compression deformation, the gear 65 and the gear 65 are meshed with each other, the threaded rod 64 rotates, the rectangular plates 52 slide in the chute 66, and because the thread directions at the two ends of the threaded rod 64 are opposite, the two rectangular plates 52 move towards the center direction of the cutter 44 at the same time, so that the custard fruit between the two rectangular plates 52 is extruded, the custard fruit is extracted into juice, and the inside the custard fruit can be fully extracted; wherein the positioning rod 61 has the function of fixing the custard apple to prevent the custard apple from sliding during the cutting and extruding processes.
As an embodiment of the present invention, a second cavity 71 is disposed inside the rectangular plate 52; a first plate 72 is connected in the second cavity 71 in a sliding manner; an insert rod 73 is fixedly connected to the side wall of the first plate 72, and the other end of the insert rod 73 is arranged in a pointed cone shape; the rectangular plate 52 is provided with a slot 74 at one side close to the cutter 44; the inserted rod 73 is connected with the slot 74 in a sliding way; an air bag 75 is fixedly connected to the part of the rectangular plate 52 positioned in the sliding groove 66, and the air bag 75 is communicated with a rodless cavity of the second cavity 71; when the device works, after the rectangular plate 52 moves towards the center of the cutter 44, the air bag 75 generates compression deformation, air inside the air bag 75 enters the rodless cavity of the second cavity 71, and the first plate 72 is pushed to move towards the center of the cutter 44, so that the insertion rod 73 is separated from the insertion slot 74, the fruit of the custard is further squeezed, the custard fruit is fully squeezed, and therefore the juice inside the custard fruit is fully squeezed.
As an embodiment of the present invention, a groove 81 is formed on the surface of the insert rod 73; the inner wall of the groove 81 is hinged with a connecting rod 82, and the other end of the connecting rod 82 is connected in the groove 81 through a spring; when the device works, when the inserting rod 73 gradually leaves the inserting groove 74, the connecting rod 82 inside the groove 81 rotates around the hinge point under the action of the elastic force of the spring, and the connecting rod 82 is inserted into the custard apple to further accelerate the crushing of the custard apple, and then the rectangular plate 52 is matched to extrude the custard apple, so that the full extraction of the juice inside the custard apple is facilitated.
In one embodiment of the present invention, a plurality of crushing teeth 9 are fixed to the outer wall of the connecting rod 82; when the device works, after the inserting rod 73 leaves the inserting groove 74, the connecting rod 82 leaves the groove 81 and is inserted into the custard apple, and at the moment, the crushing teeth 9 also extrude the custard apple and insert the custard apple into the custard apple, so that the crushing efficiency of the custard apple is improved, and the inside juice of the custard apple is fully extracted.
As an embodiment of the present invention, a plurality of sharp teeth 91 are fixed on the surface of the crushing teeth 9; a second plate 92 is connected between the sharp teeth 91 and the sharp teeth 91 in a sliding manner; a straight rod 93 is fixedly connected to one side of the second plate 92 close to the crushing teeth 9; the straight rod 93 penetrates through the crushing teeth 9 and is in sliding connection with the crushing teeth 9; the end part of the straight rod 93 is in a pointed cone shape; when the device works, after the crushing teeth 9 are inserted into the custard apple, the pointed teeth 91 are also inserted into the custard apple, and the second plate 92 between the pointed teeth 91 and the pointed teeth 91 starts to slide due to the extrusion of the custard apple, so that the straight rod 93 slides in the crushing teeth 9 and is simultaneously inserted into the custard apple near the crushing teeth 9, and the custard apple between the crushing teeth 9 and the crushing teeth 9 is crushed, thereby being beneficial to fully extracting the juice inside the custard apple.
As an embodiment of the present invention, the rectangular plate 52 is fixedly connected with the baffle 10 at the side wall located in the sliding groove 66; the inner wall of the sliding groove 66 is provided with a guide groove 11 at the corresponding position of the baffle plate 10; the baffle 10 is connected with the guide groove 11 in a sliding manner; when the device works, the baffle 10 slides left and right along with the rectangular plate 52, the baffle 10 is inserted into the guide groove 11, and the opening of the sliding groove 66 is always in a sealing state, so that the situation that the custard apple pulp enters the sliding groove 66, the situation that the surface of the threaded rod 64 is damaged due to the contamination of the threads by the custard apple pulp cannot occur, the rectangular plate 52 can normally slide in the sliding groove 66, and the custard apple can be extruded.
The working principle is as follows: firstly, the custard apple is put into the juice extracting barrel 2, then the air cylinder 41 is started, the air cylinder 41 drives the push plate 43 to move downwards through the push rod 42, the cutter 44 starts to cut the custard apple, and the push plate 43 also extrudes the custard apple, thereby realizing the crushing and juice extraction of the custard apple; the bottom of the rectangular plate 52 is lower than the bottom of the cutter 44, so that the cutter 44 is ensured not to contact with the inner side wall of the bottom of the juicing barrel 2, and the cutter 44 is prevented from damaging the inner side wall of the bottom of the juicing barrel 2; wherein the annular plate 51 also has the function of pressing the custard apple; after the cutter 44 moves downwards, because the elastic coefficient of the spring at the top of the rack 62 is larger, after the positioning rod 61 contacts the custard fruit, the positioning rod 61 is inserted into the custard fruit and cannot cause the spring to generate compression deformation, after the positioning rod 61 contacts the inner side wall of the bottom of the juicing barrel 2, the positioning rod 61 moves downwards along with the cutter 44, the spring generates compression deformation, the gear 65 and the gear 65 are meshed with each other, the threaded rod 64 rotates, the rectangular plates 52 slide in the chute 66, and because the thread turning directions at the two ends of the threaded rod 64 are opposite, the two rectangular plates 52 simultaneously move towards the central direction of the cutter 44, and further squeeze the custard fruit between the two rectangular plates 52, so that the custard fruit is squeezed into juice, and the full squeezing of the juice in the custard fruit is facilitated; wherein the positioning rod 61 has the function of fixing the custard apple to prevent the custard apple from sliding during the cutting and extrusion process; when the rectangular plate 52 moves towards the center of the cutter 44, the air bag 75 is compressed and deformed, the air in the air bag 75 enters the rodless cavity of the second cavity 71, and the first plate 72 is pushed to move towards the center of the cutter 44, so that the inserting rod 73 is separated from the slot 74, the custard apple is further squeezed, the custard apple is fully squeezed, and the juice in the custard apple is fully squeezed; when the inserting rod 73 gradually leaves the inserting slot 74, the connecting rod 82 inside the groove 81 rotates around the hinge point under the action of the elastic force of the spring, and the connecting rod 82 is inserted into the custard apple to further accelerate the crushing of the custard apple, and then the rectangular plate 52 is matched to extrude the custard apple, so that the full extraction of the juice inside the custard apple is facilitated; when the inserting rod 73 leaves the inserting groove 74, the connecting rod 82 leaves the groove 81 and is inserted into the custard apple, and the crushing teeth 9 also extrude the custard apple and insert the custard apple, so that the crushing efficiency of the custard apple is improved, and the full extraction of the juice in the custard apple is facilitated; after the crushing teeth 9 are inserted into the custard apple, the pointed teeth 91 are also inserted into the custard apple, and the second plate 92 between the pointed teeth 91 and the pointed teeth 91 starts to slide due to the extrusion of the custard apple, so that the straight rods 93 slide in the crushing teeth 9 and are simultaneously inserted into the custard apple near the crushing teeth 9, so that the custard apple between the crushing teeth 9 and the crushing teeth 9 is crushed, and the full extraction of the juice in the custard apple is facilitated; the baffle 10 slides left and right along with the rectangular plate 52, the baffle 10 is inserted into the guide groove 11, and the opening of the sliding groove 66 is always in a sealing state, so that the custard pulp is prevented from entering the sliding groove 66, the thread on the surface of the threaded rod 64 is not damaged due to the contamination of the thread by the custard pulp, and the rectangular plate 52 can normally slide in the sliding groove 66, thereby realizing the extrusion of the custard fruit.
The front, the back, the left, the right, the upper and the lower are all based on figure 3 in the attached drawings of the specification, according to the standard of the observation angle of a person, the side of the device facing an observer is defined as the front, the left side of the observer is defined as the left, and the like.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience in describing the present invention and for simplifying the description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the scope of the present invention.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. An antibacterial agent for combating escherichia coli, characterized by: the antibacterial agent consists of the following components:
20-30 parts of oregano essential oil;
25-35 parts of cinnamon essential oil;
15-25 parts of thyme essential oil;
10-15 parts of tea tree essential oil;
3-5 parts of custard apple juice.
2. An antibacterial agent against escherichia coli and a method for preparing the same according to claim 1, wherein: the custard apple juice comprises the following components in parts by weight:
10-15 parts of carbohydrate;
7-9 parts of vitamin C;
5-8 parts of protein.
3. A method for preparing an antibacterial agent against escherichia coli, characterized in that: the preparation method is suitable for the antibacterial agent for resisting escherichia coli as defined in any one of claims 1-2, and comprises the following steps:
s1: respectively placing origanum vulgaris, cinnamon, thyme and tea tree into an essential oil extraction device, and adjusting the pressure and temperature inside the extraction device to make the extraction process be carried out under the pressure of 0.5-1.5MPa and the temperature of 20-60 ℃ to respectively obtain respective essential oil extracting solutions;
s2: firstly, extracting juice from custard apple by using a juice extracting device, then putting the juice into a volumetric flask, standing for 20-30min, and taking out supernatant to obtain custard apple juice;
s3: pouring the oregano essential oil, cinnamon essential oil, thyme essential oil and tea tree essential oil obtained in the step S1 and the custard juice obtained in the step S2 into a reaction kettle, uniformly stirring by using a stirring rod at the stirring speed of 60r/min and the stirring temperature of 40-50 ℃, and then standing for 10min to complete the preparation of the antibacterial agent;
the juicing equipment of S2 comprises a base (1); the top of the base (1) is fixedly connected with a juicing barrel (2); the top of the base (1) is fixedly connected with an L-shaped supporting plate (3); a juicing unit is arranged inside the juicing barrel (2); a discharge pipe (21) is fixedly connected to the bottom of the juicing barrel (2); the juicing unit comprises a cylinder (41), a push rod (42), a push plate (43) and a cutter (44); the cylinder (41) is fixedly connected to the top of the L-shaped support plate (3); the push rod (42) is fixedly connected with the output end of the air cylinder (41); the push plate (43) is fixedly connected to the bottom end of the push rod (42); the bottom of the push plate (43) is fixedly connected with a cylindrical block (45); the cutter (44) is fixedly connected to the bottom of the cylindrical block (45).
4. A process for the preparation of an antibacterial agent against escherichia coli according to claim 3, characterized in that: an annular plate (51) is fixedly connected to the periphery of the cylindrical block (45); the bottom of the annular plate (51) is connected with a rectangular plate (52) in a sliding mode.
5. The method of claim 4 for preparing an antibacterial agent against E.coli, wherein: a positioning rod (61) is connected inside the cutter (44) in a sliding manner; the bottom end of the positioning rod (61) is arranged in a pointed cone shape, and the top end of the positioning rod is fixedly connected with a rack (62); a first cavity (63) is arranged in the cylindrical block (45); the rack (62) is connected with the inner wall of the first cavity (63) through a spring; a threaded rod (64) is rotationally connected in the first cavity (63); a gear (65) is sleeved on the periphery of the threaded rod (64), and the gear (65) is fixedly connected with the threaded rod (64); the gear (65) and the rack (62) are meshed with each other; the bottom of the annular plate (51) is provided with a pair of sliding grooves (66); two ends of the threaded rod (64) are arranged in the sliding groove (66); the threaded rod (64) is sleeved with the rectangular plate (52), and the rectangular plate (52) is rotatably connected with the threaded rod (64).
6. The method of claim 5, wherein the antibacterial agent against E.coli is prepared by: a second cavity (71) is arranged inside the rectangular plate (52); a first plate (72) is connected in the second cavity (71) in a sliding manner; an insert rod (73) is fixedly connected to the side wall of the first plate (72), and the other end of the insert rod (73) is arranged in a pointed cone shape; a slot (74) is formed in one side, close to the cutter (44), of the rectangular plate (52); the inserted rod (73) is connected with the slot (74) in a sliding way; an air bag (75) is fixedly connected to the part of the rectangular plate (52) positioned in the sliding groove (66), and the air bag (75) is communicated with a rodless cavity of the second cavity (71).
7. The process for the preparation of an antibacterial agent against escherichia coli according to claim 6, wherein: a groove (81) is formed in the surface of the inserting rod (73); the inner wall of the groove (81) is hinged with a connecting rod (82), and the other end of the connecting rod (82) is connected in the groove (81) through a spring.
8. The process for the preparation of an antibacterial agent against escherichia coli according to claim 7, wherein: the outer wall of the connecting rod (82) is fixedly connected with a plurality of crushing teeth (9).
9. The process for the preparation of an antibacterial agent against escherichia coli according to claim 8, wherein: a plurality of sharp teeth (91) are fixedly connected to the surface of the crushing tooth (9); a second plate (92) is connected between the sharp teeth (91) and the sharp teeth (91) in a sliding manner; a straight rod (93) is fixedly connected to one side, close to the crushing teeth (9), of the second plate (92); the straight rod (93) penetrates through the crushing teeth (9) and is in sliding connection with the crushing teeth (9); the end part of the straight rod (93) is in a pointed cone shape.
10. The process for the preparation of an antibacterial agent against escherichia coli according to claim 9, characterized in that: the side wall of the rectangular plate (52) in the sliding groove (66) is fixedly connected with a baffle plate (10); the inner wall of the sliding groove (66) is provided with a guide groove (11) at the corresponding position of the baffle (10); the baffle (10) is connected with the guide groove (11) in a sliding mode.
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