CN113082043A - Medicine for treating facial paralysis by traditional Chinese medicine acupoint injection - Google Patents

Medicine for treating facial paralysis by traditional Chinese medicine acupoint injection Download PDF

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CN113082043A
CN113082043A CN202110428805.6A CN202110428805A CN113082043A CN 113082043 A CN113082043 A CN 113082043A CN 202110428805 A CN202110428805 A CN 202110428805A CN 113082043 A CN113082043 A CN 113082043A
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medicine
facial paralysis
traditional chinese
treating facial
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王化兰
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51Thiamines, e.g. vitamin B1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Molecular Biology (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a medicine for treating facial paralysis by traditional Chinese medicine acupoint injection, which comprises the following components in percentage by weight: 1-3 parts of dexamethasone, 20-30 parts of vitamin B1, 1-3 parts of liduoxing factor, 0.1-0.5 part of mecobalamin, 1-3 parts of prednisone, 5-15 parts of virus suspension and 2-6 parts of dibazol. The medicine for treating facial paralysis is used for treating facial paralysis in an acupoint injection mode, has good curative effect, less pain and low cost, can effectively treat facial paralysis, and brings better application prospect.

Description

Medicine for treating facial paralysis by traditional Chinese medicine acupoint injection
Technical Field
The invention relates to the field of treatment of facial paralysis, in particular to a medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine.
Background
Facial paralysis is also known as facial muscle weakness or facial paralysis. Is the clear sign of facial paralysis. The facial expression muscles of the patient under inspection can not move autonomously, the eyebrows are raised, the forehead is not wrinkled, the eye-closing eyelids can not be closed, the mouth angle of the affected side of the mouth is closed, the drum cheek mouth angle leaks air, the nasolabial sulcus of the affected side disappears when the teeth are exposed, the mouth angle is inclined to the healthy side when smiling, and the like, and the muscles of the affected side are relaxed when touching, namely the facial nerve paralysis is obtained.
The existing medicine for treating facial paralysis has certain disadvantages in use, and has the advantages of long medicine taking time, low use curative effect, no influence on use effect and incapability of meeting the requirements of people when in use, so that the medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine is provided.
Disclosure of Invention
The invention mainly aims to provide a medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine, which can effectively solve the problems in the background technology.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following components in percentage by weight: 1-3 parts of dexamethasone, 20-30 parts of vitamin B1, 1-3 parts of liduoxing factor, 0.1-0.5 part of mecobalamin, 1-3 parts of prednisone, 5-15 parts of virus suspension and 2-6 parts of dibazol.
Preferably, the medicine for treating facial paralysis by traditional Chinese medicine acupoint injection comprises the following components in percentage by weight: 1-2 parts of dexamethasone, 20-26 parts of vitamin B1, 1-2 parts of liduoxing factor, 0.2-0.4 part of mecobalamin, 2-3 parts of prednisone, 6-12 parts of virus suspension and 2-5 parts of dibazol.
Preferably, the medicine for treating facial paralysis by traditional Chinese medicine acupoint injection comprises the following components in percentage by weight: 1 part of dexamethasone, 23 parts of vitamin B1, 2 parts of liduoxing factor, 0.3 part of mecobalamin, 2 parts of prednisone, 8 parts of viruse and 2 parts of dibazol.
Preferably, the preparation method of the medicine for treating facial paralysis by traditional Chinese medicine acupoint injection comprises the following steps:
firstly, independently placing each component of the medicine for treating facial paralysis by acupoint injection in a grinder for independent grinding to obtain medicinal powder;
② weighing the ground medicinal powder, adding the medicine into a medicinal powder mixer;
thirdly, weighing the uniformly mixed medicinal powder, and preparing the medicinal powder into a medicament;
and fourthly, packaging and sealing the medicament, and detecting product packaging.
Preferably, the pulverizer in the step (i) adopts an ultrafine pulverizer, and the ground powdery medicine is screened by using a 200-mesh screen.
Preferably, in the second step, the components of each component are weighed by an electronic weighing balance according to the proportion of the medicine for treating facial paralysis, and the medicine powder is mixed by a medicine powder mixer for 3-5 minutes to obtain uniformly mixed medicine powder.
Preferably, in the third step, 10mg of the medicinal powder is weighed by an electronic weighing balance, and then the 10mg of the medicinal powder is prepared into 6-8ml of medicament.
Preferably, the medicament prepared in the step (iv) is packaged by using the sterilized medicine bottle, and the medicament is packed in a box.
Compared with the prior art, the invention provides a medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine, which has the following beneficial effects: the medicine for treating facial paralysis treats facial paralysis by means of acupoint injection, has good curative effect, less pain and low cost, can effectively treat facial paralysis, and has the effective rate of 100 percent, the cure rate of 99 percent and good use effect.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1
A traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following components in percentage by weight: 1 part of dexamethasone, 21 parts of vitamin B1, 1 part of liduoxing factor, 0.2 part of mecobalamin, 1 part of prednisone, 7 parts of viruse and 3 parts of dibazol.
A preparation method of a traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following steps:
firstly, independently placing each component of the medicine for treating facial paralysis by acupoint injection in a grinder for independent grinding to obtain medicinal powder;
the pulverizer adopts an ultrafine pulverizer to screen the ground powdery medicine, and a 200-mesh screen is adopted during screening.
② weighing the ground medicinal powder, adding the medicine into a medicinal powder mixer;
the components of each component are weighed by an electronic weighing balance according to the proportion of the medicine for treating facial paralysis, and the medicine powder is mixed for 5 minutes by a medicine powder mixer to obtain the uniformly mixed medicine powder.
Thirdly, weighing the uniformly mixed medicinal powder, and preparing the medicinal powder into a medicament;
10mg of the powder was weighed using an electronic weighing balance, and then 10mg of the powder was made into 8ml of a drug.
Fourthly, packaging and sealing the medicament, and detecting product packaging;
the prepared medicament is packaged by a sterilized medicament bottle and is boxed.
Example 2
A traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following components in percentage by weight: 1 part of dexamethasone, 23 parts of vitamin B1, 2 parts of liduoxing factor, 0.3 part of mecobalamin, 2 parts of prednisone, 8 parts of viruse and 2 parts of dibazol.
A preparation method of a traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following steps:
firstly, independently placing each component of the medicine for treating facial paralysis by acupoint injection in a grinder for independent grinding to obtain medicinal powder;
the pulverizer adopts an ultrafine pulverizer to screen the ground powdery medicine, and a 200-mesh screen is adopted during screening.
② weighing the ground medicinal powder, adding the medicine into a medicinal powder mixer;
the components of each component are weighed by an electronic weighing balance according to the proportion of the medicine for treating facial paralysis, and the medicine powder is mixed for 5 minutes by a medicine powder mixer to obtain the uniformly mixed medicine powder.
Thirdly, weighing the uniformly mixed medicinal powder, and preparing the medicinal powder into a medicament;
10mg of the powder was weighed using an electronic weighing balance, and then 10mg of the powder was made into 8ml of a drug.
Fourthly, packaging and sealing the medicament, and detecting product packaging;
the prepared medicament is packaged by a sterilized medicament bottle and is boxed.
Example 3
A traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following components in percentage by weight: 2 parts of dexamethasone, 26 parts of vitamin B1, 3 parts of liduoxing factor, 0.4 part of mecobalamin, 2 parts of prednisone, 9 parts of viruse and 3 parts of dibazol.
A preparation method of a traditional Chinese medicine acupoint injection medicine for treating facial paralysis comprises the following steps:
firstly, independently placing each component of the medicine for treating facial paralysis by acupoint injection in a grinder for independent grinding to obtain medicinal powder;
the pulverizer adopts an ultrafine pulverizer to screen the ground powdery medicine, and a 200-mesh screen is adopted during screening.
② weighing the ground medicinal powder, adding the medicine into a medicinal powder mixer;
the components of each component are weighed by an electronic weighing balance according to the proportion of the medicine for treating facial paralysis, and the medicine powder is mixed for 5 minutes by a medicine powder mixer to obtain the uniformly mixed medicine powder.
Thirdly, weighing the uniformly mixed medicinal powder, and preparing the medicinal powder into a medicament;
10mg of the powder was weighed using an electronic weighing balance, and then 10mg of the powder was made into 8ml of a drug.
Fourthly, packaging and sealing the medicament, and detecting product packaging;
the prepared medicament is packaged by a sterilized medicament bottle and is boxed.
In the embodiment 1, the embodiment 2 and the embodiment 3, 10mg of the medicinal powder can be directly pressed into tablets for oral administration, when the medicinal preparation is prepared for use, a 10ml disposable injection needle tube is adopted to inject the medicinal preparation into two groups of Fengchi points and Bingcang points, and the medicinal preparation is injected once every 5 days, so that the curative effect of the treatment is good, the pain is less, the cost is low, and the medicinal preparation is superior to the traditional Chinese medical treatments such as Qianzhensan, acupuncture, paste, plaster, cupping and the like, not only has good effect on peripheral facial paralysis, but also has effect on central facial paralysis.
The medicine for treating facial paralysis treats facial paralysis by means of acupoint injection, has good curative effect, less pain and low cost, can effectively treat facial paralysis, and has the effective rate of 100 percent, the cure rate of 99 percent and good use effect.
The basic principles and principal features of the invention and advantages of the invention have been shown and described. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (8)

1. A medicine for treating facial paralysis by traditional Chinese medicine acupoint injection is characterized by comprising the following components in percentage by weight: 1-3 parts of dexamethasone, 20-30 parts of vitamin B1, 1-3 parts of liduoxing factor, 0.1-0.5 part of mecobalamin, 1-3 parts of prednisone, 5-15 parts of virus suspension and 2-6 parts of dibazol.
2. The medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to claim 1, is characterized in that: comprises the following components in percentage by weight: 1-2 parts of dexamethasone, 20-26 parts of vitamin B1, 1-2 parts of liduoxing factor, 0.2-0.4 part of mecobalamin, 2-3 parts of prednisone, 6-12 parts of virus suspension and 2-5 parts of dibazol.
3. The medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to claim 1, is characterized in that: comprises the following components in percentage by weight: 1 part of dexamethasone, 23 parts of vitamin B1, 2 parts of liduoxing factor, 0.3 part of mecobalamin, 2 parts of prednisone, 8 parts of viruse and 2 parts of dibazol.
4. The preparation method of the medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to any one of claims 1 to 3, which is characterized by comprising the following steps: the method comprises the following steps:
firstly, independently placing each component of the medicine for treating facial paralysis by acupoint injection in a grinder for independent grinding to obtain medicinal powder;
② weighing the ground medicinal powder, adding the medicine into a medicinal powder mixer;
thirdly, weighing the uniformly mixed medicinal powder, and preparing the medicinal powder into a medicament;
and fourthly, packaging and sealing the medicament, and detecting product packaging.
5. The preparation method of the medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to claim 4 is characterized by comprising the following steps: the step I is that a pulverizer adopts an ultrafine pulverizer to screen ground powdery medicines, and a 200-mesh screen is adopted during screening.
6. The preparation method of the medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to claim 4 is characterized by comprising the following steps: and secondly, weighing the components of each component according to the proportion of the medicine for treating facial paralysis by using an electronic weighing balance, and mixing the medicine powder for 3-5 minutes by using a medicine powder mixer to obtain uniformly mixed medicine powder.
7. The preparation method of the medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to claim 4 is characterized by comprising the following steps: and step three, weighing 10mg of the medicinal powder by adopting an electronic weighing balance, and then preparing the 10mg of the medicinal powder into 6-8ml of medicament.
8. The preparation method of the medicine for treating facial paralysis by acupoint injection in traditional Chinese medicine according to claim 4 is characterized by comprising the following steps: and step IV, packaging the prepared medicament by using the sterilized medicament bottle, and boxing the medicament.
CN202110428805.6A 2021-04-20 2021-04-20 Medicine for treating facial paralysis by traditional Chinese medicine acupoint injection Pending CN113082043A (en)

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CN202110428805.6A CN113082043A (en) 2021-04-20 2021-04-20 Medicine for treating facial paralysis by traditional Chinese medicine acupoint injection

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Application Number Priority Date Filing Date Title
CN202110428805.6A CN113082043A (en) 2021-04-20 2021-04-20 Medicine for treating facial paralysis by traditional Chinese medicine acupoint injection

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024051844A1 (en) * 2022-09-09 2024-03-14 北京达尔文细胞生物科技有限公司 Pharmaceutical composition for preventing and treating acute stage facial nerve paralysis and use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024051844A1 (en) * 2022-09-09 2024-03-14 北京达尔文细胞生物科技有限公司 Pharmaceutical composition for preventing and treating acute stage facial nerve paralysis and use thereof
WO2024051845A1 (en) * 2022-09-09 2024-03-14 北京达尔文细胞生物科技有限公司 Pharmaceutical composition for preventing and treating sequelae stage facial nerve paralysis, and use thereof
WO2024051843A1 (en) * 2022-09-09 2024-03-14 北京达尔文细胞生物科技有限公司 Pharmaceutical composition for preventing and treating convalescent stage facial nerve paralysis and use thereof

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