CN113081897A - Medical ray skin antibacterial repairing agent - Google Patents
Medical ray skin antibacterial repairing agent Download PDFInfo
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- A61K8/733—Alginic acid; Salts thereof
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention discloses a medical ray skin antibacterial repairing agent, relating to the field of medical ray skin antibacterial repairing agents, wherein the medical ray skin antibacterial repairing agent comprises the following effective components: superoxide dismutase (SOD), polyethylene glycol 400, methyl p-hydroxybenzoate, triethanolamine content, glycerol content, sodium alginate content, SOD stabilizer and purified water; the contents of superoxide dismutase (SOD) and polyethylene glycol 400 are respectively 0.622%, 1.1%, 0.2%, 1.2%, 11.2%, 6.1%, 0.28% and 79.298%, respectively. The antibacterial repairing agent can effectively eliminate the damage of superoxide radicals to skin and mucosa caused by physicochemical factors such as medical rays and the like, can effectively prevent radiation injury inflammation, has the functions of eliminating superoxide radicals, resisting bacteria and preserving moisture, has the functions of sterilization and anti-inflammation, keeps the clean and moist environment of the skin and is beneficial to skin healing.
Description
Technical Field
The invention relates to the field of medical ray skin antibacterial repairing agents, in particular to a medical ray skin antibacterial repairing agent.
Background
Radiotherapy is to irradiate a diseased part of a human body by using high-energy rays to damage and necrose cells of the diseased tissue so as to achieve the purpose of treatment, but the irradiated part often comprises not only diseased tissues but also normal tissues, and the cells of the normal tissues are also damaged by the rays, so that an external medicine for treating the irradiated part needs to be developed aiming at the problem;
in the prior art, the medical radiotherapy skin care agent disclosed in patent No. CN201410172664.6 can enhance the tolerance of skin to rays and keep the skin in a clean and dry state; the skin itching and pain can be relieved, a protective agent oil film is formed on the surface of the skin, the local temperature drop can not be caused, and the continuous repair of the skin can be promoted.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a medical ray skin antibacterial repairing agent which can effectively solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the medical ray skin antibacterial repairing agent comprises the following effective components: superoxide dismutase (SOD), polyethylene glycol 400, methyl p-hydroxybenzoate, triethanolamine content, glycerol content, sodium alginate content, SOD stabilizer and purified water; the contents of superoxide dismutase (SOD) and glycol are respectively 0.5-0.8%, 1-3%, 0.1-0.3%, 1-3%, 10-12%, 6-8%, 0.2-0.4% and 75-90% respectively;
the preparation process of the medical ray skin antibacterial repairing agent comprises the following steps:
step 1, preparing raw materials, and preparing the raw materials with corresponding weight according to the weight of the repairing agent to be prepared;
step 2, pouring the raw materials into a stirrer according to the corresponding weight percentage;
step 3, crushing the materials in the step two, pouring purified water according to the weight percentage to stir the materials, taking out the materials after stirring, putting the materials into a constant-temperature heating box, heating and solidifying the materials, and then, naturally drying the materials in a sterile environment;
and 4, finishing the preparation of the antibacterial repairing agent, and packaging the product after radiation sterilization.
Preferably, the medical ray skin antibacterial repairing agent comprises, by weight, 0.5% of superoxide dismutase (SOD), 1% of polyethylene glycol 400, 0.1% of p-hydroxybenzoic acid methanol, 1% of triethanolamine, 10% of glycerol, 6% of sodium alginate, 0.2% of SOD stabilizer and 75% of purified water.
Preferably, the medical ray skin antibacterial repairing agent comprises, by weight, 0.622% of superoxide dismutase (SOD), 1.1% of polyethylene glycol 400, 0.2% of methyl p-hydroxybenzoate, 1.2% of triethanolamine, 11.2% of glycerol, 6.1% of sodium alginate, 0.28% of SOD stabilizer and 79.298% of purified water.
Preferably, the medical ray skin antibacterial repairing agent comprises, by weight, 0.7% of superoxide dismutase (SOD), 2.2% of polyethylene glycol 400, 0.23% of methyl p-hydroxybenzoate, 1.5% of triethanolamine, 11% of glycerol, 6.3% of sodium alginate, 0.3% of SOD stabilizer and 82% of purified water.
Preferably, the medical ray skin antibacterial repairing agent comprises, by weight, 0.8% of superoxide dismutase (SOD), 3% of polyethylene glycol 400, 0.3% of methyl p-hydroxybenzoate, 3% of triethanolamine, 12% of glycerol, 8% of sodium alginate, 0.4% of SOD stabilizer and 90% of purified water.
Preferably, the stirring time in the step 2 is 20-30min, and the heating temperature of the incubator is kept at 80-100 ℃.
Preferably, the purified water used in step 3 is prepared by the following steps: multi-medium filtration, active carbon filtration, primary desalting and mixed bed.
Preferably, the skin antibacterial repairing agent prepared by the steps 1-3 is not required to be placed in a sterile environment.
Compared with the prior art, the invention has the beneficial effects that:
the antibacterial repairing agent can effectively remove the damage of superoxide radicals to skin and mucosa caused by physicochemical factors such as medical rays and the like through adding superoxide dismutase (SOD), polyethylene glycol 400, p-hydroxybenzoic acid methanol, triethanolamine content, glycerin content, sodium alginate content, an SOD stabilizer and purified water, can effectively prevent radiation injury inflammation, has the functions of removing superoxide radicals, resisting bacteria and preserving moisture, and has the main effects of: sterilizing, relieving inflammation, keeping skin clean and moist, and promoting skin healing.
Drawings
FIG. 1 is a schematic diagram showing the components of a medical ray skin antibacterial repairing agent of the present invention;
FIG. 2 is a flow chart of the preparation of the medical ray skin antibacterial repairing agent of the invention.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Step one, step 1, preparing raw materials, and preparing the following raw materials with corresponding weight according to the weight of the repairing agent to be prepared: 0.5 percent of superoxide dismutase (SOD), 1 percent of polyethylene glycol 400, 0.1 percent of p-hydroxybenzoic acid methanol, 1 percent of triethanolamine, 10 percent of glycerol, 6 percent of sodium alginate, 0.2 percent of SOD stabilizer and 75 percent of purified water;
step 2, pouring the raw materials into a stirrer according to the corresponding weight percentage;
step 3, crushing the materials in the step two, pouring purified water according to the weight percentage to stir the materials, taking out the materials after stirring, putting the materials into a constant-temperature heating box, heating and solidifying the materials, and then, naturally drying the materials in a sterile environment;
and 4, finishing the preparation of the antibacterial repairing agent, and packaging the product after radiation sterilization.
Example 2
Step 1, preparing raw materials, and preparing the following raw materials with corresponding weight according to the weight of the repairing agent to be prepared: the medical ray skin antibacterial repairing agent comprises, by weight, 0.622% of superoxide dismutase (SOD), 1.1% of polyethylene glycol 400, 0.2% of methyl p-hydroxybenzoate, 1.2% of triethanolamine, 11.2% of glycerol, 6.1% of sodium alginate, 0.28% of SOD stabilizer and 79.298% of purified water;
step 2, pouring the raw materials into a stirrer according to the corresponding weight percentage;
step 3, crushing the materials in the step two, pouring purified water according to the weight percentage to stir the materials, taking out the materials after stirring, putting the materials into a constant-temperature heating box, heating and solidifying the materials, and then, naturally drying the materials in a sterile environment;
and 4, finishing the preparation of the antibacterial repairing agent, and packaging the product after radiation sterilization.
Example 3
Step 1, preparing raw materials, and preparing the following raw materials with corresponding weight according to the weight of the repairing agent to be prepared: the medical ray skin antibacterial repairing agent comprises, by weight, 0.7% of superoxide dismutase (SOD), 2.2% of polyethylene glycol 400, 0.23% of methyl p-hydroxybenzoate, 1.5% of triethanolamine, 11% of glycerol, 6.3% of sodium alginate, 0.3% of SOD stabilizer and 82% of purified water;
step 2, pouring the raw materials into a stirrer according to the corresponding weight percentage;
step 3, crushing the materials in the step two, pouring purified water according to the weight percentage to stir the materials, taking out the materials after stirring, putting the materials into a constant-temperature heating box, heating and solidifying the materials, and then, naturally drying the materials in a sterile environment;
and 4, finishing the preparation of the antibacterial repairing agent, and packaging the product after radiation sterilization.
Example 4
Step 1, preparing raw materials, and preparing the following raw materials with corresponding weight according to the weight of the repairing agent to be prepared: the medical ray skin antibacterial repairing agent comprises, by weight, 0.8% of superoxide dismutase (SOD), 3% of polyethylene glycol 400, 0.3% of methyl p-hydroxybenzoate, 3% of triethanolamine, 12% of glycerol, 8% of sodium alginate, 0.4% of SOD stabilizer and 90% of purified water;
step 2, pouring the raw materials into a stirrer according to the corresponding weight percentage;
step 3, crushing the materials in the step two, pouring purified water according to the weight percentage to stir the materials, taking out the materials after stirring, putting the materials into a constant-temperature heating box, heating and solidifying the materials, and then, naturally drying the materials in a sterile environment;
and 4, finishing the preparation of the antibacterial repairing agent, and packaging the product after radiation sterilization.
Test example 1
The medical ray skin antibacterial repairing agent comprises, by weight, 2% of superoxide dismutase (SOD), 1.1% of polyethylene glycol 400, 0.2% of methyl p-hydroxybenzoate, 1.2% of triethanolamine, 11.2% of glycerol, 6.1% of sodium alginate, 0.28% of SOD stabilizer and 79.298% of purified water;
the content of superoxide dismutase (SOD) is increased, and the prepared repairing agent has an excessively strong effect on skin, so that the skin is red and swollen for a long time, and cannot remove superoxide anion free radicals to finally achieve the effect of inhibiting cancer cells.
Test example 2
The medical ray skin antibacterial repairing agent comprises, by weight, 0.622% of superoxide dismutase (SOD), 1.1% of polyethylene glycol 400, 1% of methyl p-hydroxybenzoate, 1.2% of triethanolamine, 11.2% of glycerol, 6.1% of sodium alginate, 0.28% of SOD stabilizer and 79.298% of purified water;
the content of the p-hydroxybenzoic acid methanol is increased, and the prepared repairing agent has an excessively strong inhibiting effect on the activity of a respiratory enzyme system and an electron transfer enzyme system of microbial cells, so that the repairing agent cannot heal the microbial cells for a long time and cannot achieve the effect of facilitating skin healing.
The antibacterial repairing agent prepared in the embodiment 2 is found to have the best effect by comparing the embodiment 1, the embodiment 2, the embodiment 3, the embodiment 4, the experiment 1 and the experiment 2, and the damage of superoxide dismutase (SOD), polyethylene glycol 400, p-hydroxybenzoic acid methanol, triethanolamine content, glycerin content, sodium alginate content, SOD stabilizer and purified water on skin and mucosa caused by physicochemical factors such as medical rays can be effectively eliminated, the radiation injury inflammation can be effectively prevented, and the antibacterial repairing agent has the effects of eliminating superoxide radical, resisting bacteria and preserving moisture, and has the main effects: sterilizing, relieving inflammation, keeping skin clean and moist, and promoting skin healing.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The medical ray skin antibacterial repairing agent is characterized in that the effective components of the medical ray skin antibacterial repairing agent comprise: superoxide dismutase (SOD), polyethylene glycol 400, methyl p-hydroxybenzoate, triethanolamine content, glycerol content, sodium alginate content, SOD stabilizer and purified water; the contents of superoxide dismutase (SOD) and glycol are respectively 0.5-0.8%, 1-3%, 0.1-0.3%, 1-3%, 10-12%, 6-8%, 0.2-0.4% and 75-90% respectively;
the preparation process of the medical ray skin antibacterial repairing agent comprises the following steps:
step 1, preparing raw materials, and preparing the raw materials with corresponding weight according to the weight of the repairing agent to be prepared;
step 2, pouring the raw materials into a stirrer according to the corresponding weight percentage;
step 3, crushing the materials in the step two, pouring purified water according to the weight percentage to stir the materials, taking out the materials after stirring, putting the materials into a constant-temperature heating box, heating and solidifying the materials, and then, naturally drying the materials in a sterile environment;
and 4, finishing the preparation of the antibacterial repairing agent, and packaging the product after radiation sterilization.
2. The medical ray skin antibacterial repairing agent as claimed in claim 1, characterized in that, in parts by weight, the content of superoxide dismutase (SOD) is 0.5%, the content of polyethylene glycol 400 is 1%, the content of p-hydroxybenzoic acid methanol is 0.1%, the content of triethanolamine is 1%, the content of glycerol is 10%, the content of sodium alginate is 6%, the content of SOD stabilizer is 0.2%, and the content of purified water is 75%.
3. The medical ray skin antibacterial repairing agent as claimed in claim 1, characterized in that, in parts by weight, the content of superoxide dismutase (SOD) is 0.622%, the content of polyethylene glycol 400 is 1.1%, the content of methyl p-hydroxybenzoate is 0.2%, the content of triethanolamine is 1.2%, the content of glycerol is 11.2%, the content of sodium alginate is 6.1%, the content of SOD stabilizer is 0.28%, and the content of purified water is 79.298%.
4. The medical ray skin antibacterial repairing agent as claimed in claim 1, characterized in that, in parts by weight, the content of superoxide dismutase (SOD) is 0.7%, the content of polyethylene glycol 400 is 2.2%, the content of methyl p-hydroxybenzoate is 0.23%, the content of triethanolamine is 1.5%, the content of glycerol is 11%, the content of sodium alginate is 6.3%, the content of SOD stabilizer is 0.3%, and the content of purified water is 82%.
5. The medical ray skin antibacterial repairing agent as claimed in claim 1, characterized in that, in parts by weight, the content of superoxide dismutase (SOD) is 0.8%, the content of polyethylene glycol 400 is 3%, the content of p-hydroxybenzoic acid methanol is 0.3%, the content of triethanolamine is 3%, the content of glycerol is 12%, the content of sodium alginate is 8%, the content of SOD stabilizer is 0.4%, and the content of purified water is 90%.
6. The medical radiation skin antibacterial repairing agent according to claim 1, wherein the stirring time in the step 2 is 20-30min, and the heating temperature of the incubator is kept at 80-100 ℃.
7. The medical ray skin antibacterial repairing agent according to claim 1, wherein the purified water used in the step 3 is prepared by the following steps: multi-medium filtration, active carbon filtration, primary desalting and mixed bed.
8. The medical ray skin antibacterial repairing agent according to claim 1, wherein the skin antibacterial repairing agent prepared in the steps 1-3 is not required to be placed in a sterile environment.
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| CN202110402555.9A CN113081897A (en) | 2021-04-14 | 2021-04-14 | Medical ray skin antibacterial repairing agent |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095651A (en) * | 2006-06-27 | 2008-01-02 | 日本乐敦制药株式会社 | External composition for skin |
| CN101522265A (en) * | 2006-07-31 | 2009-09-02 | 捷通国际有限公司 | Topical skin compositions, their preparation and their use |
| CN104000748A (en) * | 2014-06-17 | 2014-08-27 | 宜昌广翔生物科技有限公司 | Medical radiotherapy skin care agent and production technology thereof |
| CN105920590A (en) * | 2016-04-28 | 2016-09-07 | 福建省乐华医药科技有限公司 | Medical x-ray protection spray |
| CN106474313A (en) * | 2015-08-26 | 2017-03-08 | 康多宝医疗健康产品（湖南）有限公司 | A kind of medical radiation-ray preventive emulsifiable paste and preparation method thereof |
| US10912753B1 (en) * | 2020-10-20 | 2021-02-09 | Bruce Wayne Miller | Topical skin care composition |
-
2021
- 2021-04-14 CN CN202110402555.9A patent/CN113081897A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095651A (en) * | 2006-06-27 | 2008-01-02 | 日本乐敦制药株式会社 | External composition for skin |
| CN101522265A (en) * | 2006-07-31 | 2009-09-02 | 捷通国际有限公司 | Topical skin compositions, their preparation and their use |
| CN104000748A (en) * | 2014-06-17 | 2014-08-27 | 宜昌广翔生物科技有限公司 | Medical radiotherapy skin care agent and production technology thereof |
| CN106474313A (en) * | 2015-08-26 | 2017-03-08 | 康多宝医疗健康产品（湖南）有限公司 | A kind of medical radiation-ray preventive emulsifiable paste and preparation method thereof |
| CN105920590A (en) * | 2016-04-28 | 2016-09-07 | 福建省乐华医药科技有限公司 | Medical x-ray protection spray |
| US10912753B1 (en) * | 2020-10-20 | 2021-02-09 | Bruce Wayne Miller | Topical skin care composition |
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Application publication date: 20210709 |