CN113057160B - Biological sample freezing management processing method - Google Patents
Biological sample freezing management processing method Download PDFInfo
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- CN113057160B CN113057160B CN202010002851.5A CN202010002851A CN113057160B CN 113057160 B CN113057160 B CN 113057160B CN 202010002851 A CN202010002851 A CN 202010002851A CN 113057160 B CN113057160 B CN 113057160B
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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Abstract
The present disclosure relates to a biological sample freezing management processing method. The method comprises the following steps: determining a liquid nitrogen tank for storing the frozen carrier; selecting a preset distribution mode according to the liquid nitrogen tank; and distributing the storage positions of the frozen carriers loaded with the biological samples according to the selected distribution mode. The scheme provided by the disclosure can avoid or reduce errors in biological sample freezing management, and can intelligently manage the inventory space of the liquid nitrogen tank, so that the use is more convenient and economic, and meanwhile, the purchase and expansion can be timely reminded.
Description
Technical Field
The disclosure relates to the technical field of medical treatment and internet, in particular to a biological sample freezing management processing method.
Background
At present, the number of frozen embryos is rapidly increasing along with the technical development of the reproductive industry and the popularization of embryo freezing technology. And, with the development of the reproductive center, liquid nitrogen tanks with different styles can be purchased at different stages. In the case of large frozen embryo quantity, the manual management of the frozen embryos by each reproductive center is very easy to make mistakes, and a large amount of manpower, material resources and time are consumed, so that the management of liquid nitrogen tanks of different styles is troublesome.
In the related art, at present, in the assignment of the freezing positions, manual assignment and recording are required, a vacant position is found, and then the freezing positions are assigned to the patient according to the vacant position. Under the condition of manual distribution, repeated distribution of freezing positions is easy to occur, so that the positions are found to be used when freezing carriers are put in storage and need to be redistributed; or forgetting to record after the distribution position, so that the couple to which the frozen carrier belongs cannot be confirmed on the spot, and the bracket with the frozen carrier is taken out of the liquid nitrogen tank for multiple times due to repeated distribution, thereby causing certain influence on the frozen embryo; if the freezing location is recorded incorrectly by the couple at the time of recording, for example, if the freezing carrier actually belongs to A couple but is recorded as B couple, serious errors will result. Similarly, in the aspect of liquid nitrogen tank management, along with the increase of the number of frozen embryos, the increase of the number of liquid nitrogen tanks and the increase of the styles of the liquid nitrogen tanks, the stock management of the liquid nitrogen tanks also needs to consume a large amount of manpower and material resources, and human errors can be caused by manual recording, for example, it is possible that no new sample is placed in a place when the storage space of the liquid nitrogen tank is full, and time is required for purchasing a new liquid nitrogen tank, so that the new sample cannot be frozen in time. In addition, the location of the positioning sample needs to be searched when the sample, such as an embryo, is thawed. When positioning, the data of the recorded freezing position attribution also needs to be found out first, and the position of the embryo freezing carrier of the patient needing to be unfrozen is found out, which also needs to consume more manpower. If a carrier of a sample is originally recorded to be placed in a position on the F support of the E bucket of the liquid nitrogen D tank, but is actually placed in another position due to manual error during storage, the sample cannot be found in the recorded position until the sample needs to be thawed, and a great deal of manpower is required to search again in each possible position.
Therefore, the biological sample freezing management processing method in the related art mainly depends on manual operation, is easy to make mistakes, is not careful in management, and brings much cost for biological sample management.
Disclosure of Invention
In order to overcome the problems in the related art, the present disclosure provides a biological sample refrigeration management processing method, which can avoid or reduce errors in biological sample refrigeration management and reduce management cost.
One aspect of the present disclosure provides a biological sample freezing management processing method, including:
determining a liquid nitrogen tank for storing the frozen carrier;
selecting a preset distribution mode according to the liquid nitrogen tank;
and distributing the storage positions of the frozen carriers loaded with the biological samples according to the selected distribution mode.
In one embodiment, the dispensing of the storage location of the frozen carrier loaded with the biological specimen according to the selected dispensing pattern comprises:
and distributing the storage positions of the frozen carriers loaded with the biological samples according to the selected non-cyclic incremental automatic distribution mode.
In one embodiment, the dispensing of the storage locations for the frozen carriers loaded with biological specimens according to the selected non-cyclical incremental automatic dispensing method comprises:
assigning a location for loading the frozen carrier with the biological specimen according to one or more of the following conditions:
the liquid nitrogen tank distinguishes the source of disease, uses empty positions in an increasing mode, the freezing carriers of the same patient have the same color, and the freezing carriers of different patients on the same bracket have different colors; or the like, or a combination thereof,
the liquid nitrogen tank is used for storing freezing carriers of the same patient in different disease sources and in the same bracket; or the like, or, alternatively,
the liquid nitrogen tank is used for distinguishing disease sources, the frozen carriers of the same patient have the same color, and the frozen carriers of different patients on the same bracket have different colors; or the like, or, alternatively,
the patient frozen carrier is stored to the empty location found first.
In one embodiment, the dispensing of the storage location of the frozen carrier loaded with the biological specimen according to the selected dispensing pattern comprises:
and dispensing the storage locations of the frozen carriers loaded with the biological samples according to the selected cyclical incremental automatic dispensing manner.
In one embodiment, said incrementally automated dispensing according to a selected cycle, dispensing a storage location for a frozen carrier loaded with a biological specimen, comprises:
dispensing a storage location for the frozen carrier loaded with the biological specimen under one or more of the following conditions:
the liquid nitrogen tank distinguishes the source of the disease, the color of the freezing carrier of the same couple is consistent, the positions of biological samples frozen by the patient on the same day are adjacent, and the adjacent empty positions are distributed to the patient when the circulation corresponding liquid nitrogen tank is newly distributed.
In one embodiment, the method further comprises:
and displaying different visual interfaces for inventory management according to different categories of the liquid nitrogen tank, wherein the visual interfaces at least comprise inventory reminders.
In one embodiment, the method further comprises:
searching and positioning the position of the freezing carrier corresponding to the patient through the acquired patient information; or the like, or, alternatively,
positioning the position of the freezing carrier corresponding to the patient by scanning a bar code, a two-dimensional code or an RFID electronic chip label associated with the same patient; or the like, or, alternatively,
and scanning the bar code, the two-dimensional code or the RFID electronic chip on the liquid nitrogen tank body or the inner pail or the support to acquire corresponding information of all patients.
In one embodiment, the method further comprises:
before the freezing carrier loaded with the biological sample is placed in the liquid nitrogen tank, respectively scanning the freezing carrier and a bar code, a two-dimensional code or an RFID electronic chip label on the tank body of the liquid nitrogen tank or a lifting barrel or a support inside the liquid nitrogen tank for checking.
Another aspect of the present disclosure provides a biological sample freezing management processing system, including:
the distribution device is used for determining a liquid nitrogen tank for storing the frozen carrier; selecting a preset distribution mode according to the liquid nitrogen tank; distributing the storage positions of the frozen carriers loaded with the biological samples according to the selected distribution mode;
and the liquid nitrogen tank is used for storing the freezing carrier.
In one embodiment, the dispensing device comprises:
a first dispensing submodule for dispensing storage locations for frozen carriers loaded with biological specimens according to a selected non-cyclic incremental automatic dispensing manner; and/or the presence of a gas in the gas,
a second dispensing sub-module for dispensing the storage locations of the frozen carriers loaded with the biological specimens according to a selected cyclic incremental automatic dispensing algorithm.
The technical scheme provided by the embodiment of the disclosure can have the following beneficial effects:
according to the scheme of the embodiment of the disclosure, the preset distribution mode is selected according to the liquid nitrogen tank, and then the storage position of the freezing carrier for loading the biological sample is distributed according to the selected distribution mode, so that the freezing position can be automatically distributed.
Further, according to the scheme of the embodiment of the disclosure, different visual interfaces can be displayed according to different types of the liquid nitrogen tanks for inventory management, automatic early warning can be realized when inventory is insufficient, and automatic inventory management is realized.
Furthermore, according to the scheme of the embodiment of the disclosure, the position of the freezing carrier corresponding to the patient can be searched and positioned through the acquired patient information; or scanning a bar code, a two-dimensional code or an RFID electronic chip label of the same patient to locate the position of the freezing carrier corresponding to the patient; or scanning the bar code, the two-dimensional code or the RFID electronic chip on the liquid nitrogen tank body or the inner pail or the bracket to obtain corresponding information of all patients, thereby realizing automatic positioning of the freezing position of the patients.
Furthermore, in the scheme of the embodiment of the disclosure, before the frozen carrier loaded with the biological sample is placed in the liquid nitrogen tank, the bar code, the two-dimensional code or the RFID electronic chip label on the frozen carrier and the tank body of the liquid nitrogen tank or the inner pail or the support can be respectively scanned for checking, so that position checking is realized, and accidents caused by wrong placement positions are avoided.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure.
Drawings
The above and other objects, features and advantages of the present disclosure will become more apparent by describing in greater detail exemplary embodiments thereof with reference to the attached drawings, in which like reference numerals generally represent like parts throughout.
Fig. 1 is a schematic flow diagram illustrating a biological specimen freezing management process according to an exemplary embodiment of the present disclosure;
FIG. 2 is another schematic diagram illustrating a flow of a biological specimen freeze management processing method according to an exemplary embodiment of the present disclosure;
fig. 3 is a schematic structural diagram illustrating a biological specimen freezing management processing system according to an exemplary embodiment of the present disclosure;
FIG. 4 is another schematic diagram illustrating the structure of a biological specimen freezing management processing system according to an exemplary embodiment of the present disclosure;
FIG. 5 is a schematic diagram illustrating a computing device in accordance with an exemplary embodiment of the present disclosure.
Detailed Description
Preferred embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While the preferred embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
The terminology used in the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in this disclosure and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
It should be understood that although the terms "first," "second," "third," etc. may be used in this disclosure to describe various information, these information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the present disclosure. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present disclosure, "a plurality" means two or more unless specifically limited otherwise.
The present disclosure provides a biological sample refrigeration management processing method, which can avoid or reduce errors and avoid or reduce errors in biological sample refrigeration management, and reduce management cost.
Technical solutions of embodiments of the present disclosure are described in detail below with reference to the accompanying drawings.
Fig. 1 is a schematic flow diagram illustrating a biological specimen freezing management processing method according to an exemplary embodiment of the present disclosure.
Referring to fig. 1, the method flow includes:
in step 101, a liquid nitrogen tank for storing the frozen carrier is determined.
The class of liquid nitrogen tanks in the present disclosure may include, but is not limited to, non-stratified liquid nitrogen tanks and non-stratified liquid nitrogen tanks.
In step 102, a preset distribution mode is selected according to the liquid nitrogen tank.
In the disclosure, different distribution modes can be respectively adopted according to the non-layering type and the layering type of the liquid nitrogen tank, but the method is not limited to the method, and the type difference between the layering type and the non-layering type can also be not considered.
In the present disclosure, the non-layered liquid nitrogen tank and the layered liquid nitrogen tank are described by taking different distribution modes as examples. For example, when the type of the liquid nitrogen tank is a non-layering liquid nitrogen tank, the storage position of a freezing carrier loaded with a biological sample is distributed by adopting a non-cyclic incremental automatic distribution algorithm according to the selected non-layering liquid nitrogen tank distribution mode; and when the type of the liquid nitrogen tank is a layered liquid nitrogen tank, distributing the storage position of the freezing carrier loaded with the biological sample by adopting a circular incremental automatic distribution algorithm according to the selected layered liquid nitrogen tank distribution mode.
It should be noted that, the above is only an example, and in the non-layered liquid nitrogen tank distribution manner, a cyclic incremental automatic distribution algorithm may also be adopted, while in the layered liquid nitrogen tank distribution manner, a non-cyclic incremental automatic distribution algorithm may also be adopted, and flexible setting may be performed as required.
In step 103, the storage location of the frozen carrier loaded with the biological specimen is assigned according to the selected assignment.
The biological sample described in the present disclosure may be, for example, a sperm, an ovum, an embryo, or the like.
It can be found that according to the scheme of the embodiment of the disclosure, a preset distribution mode is selected according to the liquid nitrogen tank, and then the storage position of the freezing carrier loaded with the biological sample is distributed according to the selected distribution mode, so that the freezing position can be automatically distributed.
Fig. 2 is another schematic view of a flow chart of a biological specimen freezing management processing method according to an exemplary embodiment of the present disclosure. Fig. 2 depicts aspects of the present disclosure in more detail with respect to fig. 1.
It should be noted that fig. 2 illustrates, but is not limited to, the non-cyclic incremental automatic allocation algorithm adopted when the type of the liquid nitrogen tank is the non-layered liquid nitrogen tank, and the cyclic incremental automatic allocation algorithm adopted when the type of the liquid nitrogen tank is the layered liquid nitrogen tank, or the non-cyclic incremental automatic allocation algorithm adopted in the non-layered liquid nitrogen tank allocation manner or the layered liquid nitrogen tank allocation manner, that is, the respective preset algorithms in the non-layered liquid nitrogen tank and the layered liquid nitrogen tank may be mutually selected and used.
Referring to fig. 2, the method flow includes:
in step 201, the liquid nitrogen tank class is determined.
The class of liquid nitrogen tanks described in this disclosure includes, but is not limited to, two styles of liquid nitrogen tanks, the most common of which is a non-stratified liquid nitrogen tank and the other of which is a stratified liquid nitrogen tank. The non-layering liquid nitrogen tank is internally provided with a plurality of lifting barrels, the lifting barrels are not layered, each lifting barrel also comprises a plurality of supports, and at most, a plurality of freezing carriers can be arranged on the supports; the layered liquid nitrogen tank is internally provided with a plurality of lifting barrels, the lifting barrels are layered, and a plurality of freezing carriers can be stored in one layer.
In step 202, selecting a non-layered liquid nitrogen tank distribution mode according to the type of the non-layered liquid nitrogen tank, and entering step 203.
The scheme disclosed by the invention can be automatically adapted to liquid nitrogen tanks with various specification types and different storage space modes (for example, some liquid nitrogen tanks are not layered, and some liquid nitrogen tanks are layered), and different preset distribution modes can be selected according to the specification types.
In step 203, the storage position of the frozen carrier loaded with the biological sample is allocated according to the selected non-layering liquid nitrogen tank allocation mode, and the process goes to step 206.
According to the scheme disclosed by the invention, different algorithms for automatically distributing the positions of the frozen carriers can be configured according to different liquid nitrogen tank styles. With the development of the reproductive center, the purchased liquid nitrogen tanks are various in style and increased in number, errors are easy to occur in artificial distribution, the embryos cannot be quickly confirmed due to forgetting to record after distribution, the supports with the frozen carriers are taken out of the liquid nitrogen tanks for multiple times due to repeated distribution, and certain influence is caused on the frozen embryos. Therefore, the present disclosure proposes a configurable automatic allocation algorithm, which is also an allocation algorithm for different freezing positions configured for different types of liquid nitrogen tanks.
For example, for a non-stratified liquid nitrogen tank, a variety of algorithms may be used:
algorithm 1: a differentiated color increment auto-assignment algorithm.
The algorithm may be set to meet one or more of the following conditions: the liquid nitrogen tank distinguishes the source of the disease (different liquid nitrogen tanks are selected according to different disease types); incrementally using the empty locations; the freezing carriers of the same patient have the same color (the same patient adopts the same color freezing carrier); the colors of the freezing carriers of different patients in the same bracket are different.
The following may be specifically set:
1) the user sets the distributable liquid nitrogen tank and the corresponding disease source of the liquid nitrogen tank, and if no disease source exists, the distributable liquid nitrogen tank indicates that any disease source can be distributed.
2) When frozen, the color of the frozen carrier used by the patient before is displayed.
3) The last rack currently available for dispensing, how many positions remain, which colors have been used, is displayed.
4) Depending on stent usage, prompts are provided for which patients may be assigned to the current stent, directing the user to select which patients may be assigned.
5) After the user selects the patient, and detects a click to add a frozen carrier, the system assigns a frozen location to the patient's biological specimen in a self-increment manner.
The freezing carrier provided by the present disclosure may include, but is not limited to, a carrier rod body and a carrier rod outer sleeve. The slide bar body may include a handle portion, an intermediate portion connected with the handle portion, and a slide portion connected with the intermediate portion; wherein the slide portion is for storing a biological sample; the slide glass part is provided with a biological sample, the slide glass part is provided with a handle, the carrier rod body can be embedded with an electronic chip label, the electronic chip label is positioned at the handle part or the middle part, and the electronic chip label is used for storing patient identity information and sample information corresponding to the biological sample stored in the slide glass part. The biological sample stored in the slide portion may be sperm, ovum, embryo, or the like.
The freezing carrier provided by the disclosure is generally placed in a liquid nitrogen tank for storage, the RFID electronic chip label embedded in the freezing carrier can be stored for a long time under liquid nitrogen without damage, and information can be normally read after the RFID electronic chip label is taken out from the liquid nitrogen tank and placed at normal temperature. Because embedded electronic chip label has used more stable inner structure and chip package mode in the design, no longer use the fixed mode such as glue bonding that probably receives the temperature influence for can not receive expend with heat and contract with cold's influence and damage when business turn over liquid nitrogen environment.
And 2, algorithm: and storing the frozen carriers of the same patient in the same bracket on the same day.
The algorithm may be set to meet one or more of the following conditions: the liquid nitrogen tank is used for storing frozen carriers of the same patient according to different disease sources and the same support.
For example, the algorithm may be set to: 1. the frozen carriers of the same patient exist in the same bracket as much as possible when stored on the same day; 2. when the number exceeds the storage capacity of one bracket, the bracket can be placed in two brackets; 3. the sources of the diseases are distinguished.
The following may be specifically set:
1) the user sets the distributable liquid nitrogen tank, the liquid nitrogen tank corresponds to the disease source, and if no disease source exists, the distributable liquid nitrogen tank indicates that any disease source can be distributed.
2) When the freezing process is carried out, the number of freezing carriers to be frozen of a patient is obtained, and when the number of the carrier rods is larger than the maximum storage number n of the support, the number of the freezing carriers of the patient is changed into n + n +. For example, the number of the patient freezing carriers is 7, the support is stored for 4 at the maximum, and then the patient freezing carriers are divided into 4+3 parts, wherein 4 carrying rods are stored in the same new support, and the other 3 carrying rods are stored on the support capable of storing 3 carrying rods, namely the support empty position is more than or equal to 3.
3) For the hypothetical case of 2), if the last 3 frozen carriers of the patient do not have a rack with 3 positions left, then the number of frozen carriers of the patient is automatically divided into 2+1, and so on.
And (3) algorithm: the color of the freezing carrier of the same patient is not changed, and the color of the freezing carrier of different patients of the same bracket is different.
The algorithm is set to meet one or more of the following conditions: the liquid nitrogen tank distinguishes the source of disease, the freezing carriers of the same patient have the same color, and the freezing carriers of different patients on the same bracket have different colors.
For example, the algorithm may be set to: 1. distinguishing disease sources; 2. the freezing carrier of the same patient has only one color; 3. the freezing carrier colors of different patients in the same bracket are different.
The following may be specifically set:
1) the user sets the distributable liquid nitrogen tank, the liquid nitrogen tank corresponds to the disease source, and if no disease source exists, the distributable liquid nitrogen tank indicates that any disease source can be distributed.
2) During freezing, the color of the patient freezing carrier is obtained, and if the color does not exist, the system automatically recommends or the user manually determines one.
3) According to the color of the patient freezing carrier, finding a bracket capable of storing the color of the patient freezing carrier, namely a freezing position.
And algorithm 4: indifferent incremental algorithms.
The algorithm is set to meet one or more of the following conditions: the indifferent incremental change is achieved by depositing the patient's frozen carrier into the empty location found first.
The algorithm is the simplest, and only increases blindly, and when freezing each time, the patient freezing carrier is stored in the empty position which is found first.
It should be noted that the algorithm of the non-stratified liquid nitrogen tank distribution method can also be applied to stratified liquid nitrogen tanks.
In step 204, a layered liquid nitrogen tank distribution mode is selected according to the type of the liquid nitrogen tank as a layered liquid nitrogen tank, and the process enters step 205.
In step 205, the storage location of the frozen carrier loaded with the biological specimen is assigned according to the selected stratified liquid nitrogen tank distribution method, and the process proceeds to step 206.
For example, a cyclic incremental automatic dispensing algorithm may be used for a stratified liquid nitrogen tank, which is set to meet one or more of the following conditions: the liquid nitrogen tank distinguishes the source of the disease (different liquid nitrogen tanks are selected according to different disease types), the colors of the freezing carriers of the same couple are consistent, the biological samples frozen by the patient on the same day, such as embryos, are adjacent, and the circulation corresponding liquid nitrogen tank distributes the adjacent empty positions to the patient when the liquid nitrogen tank is newly distributed.
The following may be specifically set:
1) the user sets the distributable liquid nitrogen tank and the corresponding disease source of the liquid nitrogen tank, and if no disease source exists, the distributable liquid nitrogen tank indicates that any disease source can be distributed.
2) When frozen, the color of the frozen carrier used by the patient before is displayed.
3) And when the button for adding the frozen carrier is detected to be clicked, circulating the corresponding liquid nitrogen tank, distributing the corresponding adjacent empty positions to the patient sample, and if the button for adding is clicked again, redistributing.
It should be noted that the algorithm of the above-mentioned hierarchical liquid nitrogen tank distribution method can also be applied to non-hierarchical liquid nitrogen tanks.
In step 206, according to different categories of the liquid nitrogen tank, displaying different visual interfaces for inventory management, wherein at least an inventory reminder is included.
According to the scheme, different visual liquid nitrogen tank inventory management can be configured according to different liquid nitrogen tank styles, and early warning can be given when inventory is insufficient.
At present, with the development of a reproductive center, one reproductive center is likely to purchase liquid nitrogen tanks of different models, visual interfaces of different types of liquid nitrogen tanks can be designed to be different in order to be matched with various types of liquid nitrogen tanks, and even if the reproductive center has different types of liquid nitrogen tanks, a system can be managed simultaneously and is managed without errors strictly according to different types. When the inventory is insufficient, a corresponding prompt is made, for example, the position of the liquid nitrogen tank with the hepatitis B as the source of the disease is about to run out, the system can give a prompt in advance and the liquid nitrogen tank needs to be added.
In step 207, before the frozen carrier loaded with the biological sample is placed in the liquid nitrogen tank, the frozen carrier and a bar code, a two-dimensional code or an RFID electronic chip label on the tank body of the liquid nitrogen tank or an inner pail or a bracket of the liquid nitrogen tank are respectively scanned for checking.
The scheme disclosed by the invention can be used for checking the position by combining the handset, the two-dimension code, the bar code and the RFID technology, for example, after the storage position is allocated, before the biological sample is really placed in the specific position of the allocated liquid nitrogen tank, the bar code/two-dimension code/RFID electronic tag on the freezing carrier can be scanned or sensed by the handset, and the bar code/two-dimension code/RFID electronic tag on the tank body of the liquid nitrogen tank or on a lifting cylinder in the liquid nitrogen tank or on a support can be scanned at the same time for information checking, so that the carrying rod is ensured to be placed in the position which the carrying rod needs to be placed, the position which is not misplaced is ensured, and the occurrence of error accidents is avoided.
In step 208, the location of the frozen carrier is located in a variety of ways.
After the freezing carrier is stored in the liquid nitrogen tank, the corresponding position of the freezing carrier can be positioned by scanning the bar code, the two-dimensional code or the RFID electronic chip label of the same patient. It should be noted that these identification media may be on a patient's clinical chart or other sample carrier, or on another refrigerated carrier, and the present disclosure is not limited thereto and may be flexibly configured as desired.
According to the scheme, the position of the freezing carrier corresponding to the patient can be located through the acquired patient information in the locating process; or, the position of the freezing carrier corresponding to the patient is positioned by scanning a bar code, a two-dimensional code or an RFID electronic chip label; or scanning a bar code, a two-dimensional code or an RFID electronic chip on the liquid nitrogen tank body or the inner pail or the support to acquire corresponding information of all patients.
For example, the RFID chip can be sensed by the handset, and if the RFID chip is assigned to belong to a couple of couples, the system can locate the position of the patient corresponding to all the freezing carriers through the patient information obtained by the sensing chip.
For example, in the related art, it is time-consuming to manually search for a patient and a hospital case system one-to-one, and the positioning of the frozen carrier takes too much time when thawing a patient who is subjected to temporary transplantation, which may cause troubles to the patient who can perform the transplantation operation. According to the scheme, for the patients with resuscitation transplantation operation notice, the positions of all patient freezing carriers can be located through the transplantation date, the detailed information of the freezing carriers is displayed, an operator can judge which carrier rods are specifically thawed according to the detailed information of embryos in the freezing carriers, and after selection, a thawing list is directly printed.
For example, aspects of the present disclosure may also locate all frozen carrier information for a single patient, including location, frozen embryo score information, and the like.
For example, the present disclosure may scan a bar code, a two-dimensional code, or an RFID electronic chip on a pail or a stand of the liquid nitrogen tank through various terminal devices such as a handset, etc., to obtain corresponding patient information. That is, the barcode/two-dimensional code/RFID tag on the liquid nitrogen container body or the inner lifting cylinder or the holder is scanned by the handheld device at ordinary times, and the information of all biological samples stored at the position can be conveniently known.
According to the scheme of the embodiment, automatic distribution of the freezing position, automatic inventory management, automatic positioning of the unfreezing position of the patient and storage and checking of the freezing position can be achieved, in cooperation with management of a liquid nitrogen tank of a reproductive center, output of a large amount of manpower and material resources is reduced for the center, in addition, the permanent memory and error-free operation of a computer are matched, errors are avoided or reduced, a vital effect can be achieved on embryo freezing management, and a plurality of problems that distribution is time-consuming, errors are prone to occurring, liquid nitrogen tank inventory management is inconvenient, unfreezing positioning is time-consuming and errors prone to occurring and the like are solved for traditional embryo freezing management.
That is, the scheme of the present disclosure may implement: 1) automatically allocating the storage positions of the frozen carriers according to a preset algorithm; 2) automatically managing the stock (checking the stock state at any time, and reminding the user to buy a new liquid nitrogen tank when the rest position is not enough); 3) The storage position of the frozen carrier is accurately searched and positioned, so that the carrier is convenient to take out and use; 4) liquid nitrogen tanks (for example, some liquid nitrogen tanks are not layered, and some liquid nitrogen tanks are layered) which are automatically adapted to various specification types and different storage space modes; 5) the frozen carrier also has a checking function when entering and exiting the liquid nitrogen tank, and can be checked to prevent manual misplacement.
More specifically, the scheme of the embodiment of the disclosure can realize automatic allocation of freezing positions, and on the aspect of matching with the management of a liquid nitrogen tank in a reproductive center, a large amount of manpower and material resources output can be reduced for the center, so that errors are avoided. Further, according to the scheme of the embodiment of the disclosure, different visual interfaces can be displayed for inventory management according to different types of the liquid nitrogen tanks, automatic early warning can be performed when inventory is insufficient, and automatic inventory management is achieved. Furthermore, the scheme of the embodiment of the disclosure can position the position of the freezing carrier corresponding to the patient through the acquired patient information; or, the position of the freezing carrier corresponding to the patient is positioned by scanning a bar code, a two-dimensional code or an RFID electronic chip label; or scanning a bar code, a two-dimensional code or an RFID electronic chip on the liquid nitrogen tank body or the inner pail or the support to obtain corresponding patient information, thereby realizing automatic positioning of the freezing position of the patient. Furthermore, in the scheme of the embodiment of the disclosure, before the frozen carrier loaded with the biological sample is placed in the liquid nitrogen tank, the frozen carrier and a bar code, a two-dimensional code or an RFID electronic chip label on the tank body of the liquid nitrogen tank or a lifting bucket or a support inside the tank body of the liquid nitrogen tank are respectively scanned for checking, so that position checking is realized, and accidents caused by distribution errors are avoided.
Corresponding to the embodiment of the application function implementation method, the disclosure also provides a biological sample refrigeration management processing system, a terminal device and a corresponding embodiment.
Fig. 3 is a schematic structural diagram illustrating a biological specimen freezing management processing system according to an exemplary embodiment of the present disclosure.
Referring to fig. 3, a biological sample freezing management processing system of the present disclosure includes: a distribution device 31 and a liquid nitrogen tank 32.
A dispensing device 31 for defining a liquid nitrogen tank for storing the frozen carriers; selecting a preset distribution mode according to the liquid nitrogen tank; and distributing the storage positions of the frozen carriers loaded with the biological samples according to the selected distribution mode.
The liquid nitrogen tank category in the present disclosure may include two types, but is not limited to, a non-stratified liquid nitrogen tank and a non-stratified liquid nitrogen tank, and the non-stratified liquid nitrogen tank respectively adopt different distribution modes. For example, the non-cyclic incremental automatic allocation algorithm may be adopted when the liquid nitrogen tank is a non-layered liquid nitrogen tank, and the cyclic incremental automatic allocation algorithm may be adopted when the liquid nitrogen tank is a layered liquid nitrogen tank, but the present invention is not limited thereto, and the non-cyclic incremental automatic allocation algorithm may also be adopted in the non-layered liquid nitrogen tank allocation manner or the non-cyclic incremental automatic allocation algorithm may also be adopted in the layered liquid nitrogen tank allocation manner, that is, the respective preset algorithms in the non-layered liquid nitrogen tank and the layered liquid nitrogen tank may also be mutually selected and used
And a liquid nitrogen tank 32 for storing the frozen carrier. The frozen carrier is generally placed in a liquid nitrogen tank for storage, the RFID electronic chip tag embedded in the frozen carrier can be stored for a long time under liquid nitrogen without being damaged, and the information can be normally read after the RFID electronic chip tag is taken out of the liquid nitrogen tank and placed at normal temperature. Because embedded electronic chip label has used more stable inner structure and chip package mode in the design, no longer use the fixed mode such as glue bonding that probably receives the temperature influence for can not receive expend with heat and contract with cold's influence and damage when business turn over liquid nitrogen environment.
According to the scheme of the embodiment of the disclosure, the preset distribution mode is selected according to the liquid nitrogen tank, and then the storage position of the freezing carrier for loading the biological sample is distributed according to the selected distribution mode, so that the freezing position can be automatically distributed.
Fig. 4 is another schematic diagram illustrating a configuration of a biological specimen freezing management processing system according to an exemplary embodiment of the present disclosure.
Referring to fig. 4, a biological sample freezing management processing system of the present disclosure includes: a distribution device 31 and a liquid nitrogen tank 32.
The functions of the distribution device 31 and the liquid nitrogen tank 32 can be seen from the description in fig. 3.
In one embodiment, the dispensing device 31 may include: a first allocation submodule 311 and/or a second allocation submodule 312.
A first dispensing submodule 311 for dispensing the location of the frozen carrier loaded with the biological sample according to the selected acyclic incremental automatic dispensing mode.
The algorithm of the allocation may be set to meet one or more of the following conditions:
the liquid nitrogen tank distinguishes the source of disease, uses empty positions in an increasing mode, the freezing carriers of the same patient have the same color, and the freezing carriers of different patients on the same bracket have different colors; or the liquid nitrogen tank distinguishes the source of the disease, and the same bracket stores the freezing carrier of the same patient; or the liquid nitrogen tank distinguishes the source of disease, the freezing carriers of the same patient have the same color, and the freezing carriers of different patients on the same bracket have different colors; alternatively, indiscriminate increments are achieved by depositing the patient's frozen carrier into the empty location found first. It should be noted that the algorithm of the non-hierarchical liquid nitrogen tank distribution mode can also be applied to hierarchical liquid nitrogen tanks
A second dispensing sub-module 312 for dispensing locations of the frozen carriers loaded with the biological samples according to a selected cyclic incremental automatic dispensing algorithm.
The algorithm of the allocation may be set to meet one or more of the following conditions: the liquid nitrogen tank distinguishes the source of the disease (different liquid nitrogen tanks are selected according to different disease types), the colors of the freezing carriers of the same couple are consistent, the biological samples frozen by the patient on the same day, such as embryos, are adjacent, and the circulation corresponding liquid nitrogen tank distributes the adjacent empty positions to the patient when the liquid nitrogen tank is newly distributed. It should be noted that the algorithm of the above-mentioned hierarchical liquid nitrogen tank distribution method can also be applied to non-hierarchical liquid nitrogen tanks.
With regard to the apparatus in the above-described embodiment, the specific manner in which each module performs the operation has been described in detail in the embodiment related to the method, and will not be elaborated here.
FIG. 5 is a schematic diagram illustrating a computing device, according to an example embodiment of the present disclosure.
Referring to fig. 5, computing device 500 includes memory 510 and processor 520.
The Processor 520 may be a Central Processing Unit (CPU), other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA) or other Programmable logic device, discrete Gate or transistor logic, discrete hardware components, etc. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.
The memory 510 may include various types of storage units, such as system memory, Read Only Memory (ROM), and a persistent storage device. Wherein the ROM may store static data or instructions that are needed by the processor 1020 or other modules of the computer. The persistent storage device may be a read-write storage device. The persistent storage may be a non-volatile storage device that does not lose stored instructions and data even after the computer is powered off. In some embodiments, the persistent storage device employs a mass storage device (e.g., magnetic or optical disk, flash memory) as the persistent storage device. In other embodiments, the permanent storage may be a removable storage device (e.g., floppy disk, optical drive). The system memory may be a read-write memory device or a volatile read-write memory device, such as a dynamic random access memory. The system memory may store instructions and data that some or all of the processors require at runtime. Further, the memory 510 may include any combination of computer-readable storage media, including various types of semiconductor memory chips (DRAM, SRAM, SDRAM, flash memory, programmable read-only memory), magnetic and/or optical disks, may also be employed. In some embodiments, memory 1010 may include a removable storage device that is readable and/or writable, such as a Compact Disc (CD), a read-only digital versatile disc (e.g., DVD-ROM, dual layer DVD-ROM), a read-only Blu-ray disc, an ultra-density optical disc, a flash memory card (e.g., SD card, min SD card, Micro-SD card, etc.), a magnetic floppy disc, or the like. Computer-readable storage media do not contain carrier waves or transitory electronic signals transmitted by wireless or wired means.
The memory 510 has stored thereon executable code that, when processed by the processor 1020, may cause the processor 520 to perform some or all of the methods described above.
The aspects of the present disclosure have been described in detail above with reference to the accompanying drawings. In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments. Those skilled in the art should also appreciate that the acts and modules referred to in the specification are not necessarily required by the disclosure. In addition, it can be understood that steps in the method of the embodiment of the present disclosure may be sequentially adjusted, combined, and deleted according to actual needs, and modules in the device of the embodiment of the present disclosure may be combined, divided, and deleted according to actual needs.
Furthermore, the method according to the present disclosure may also be implemented as a computer program or computer program product comprising computer program code instructions for performing some or all of the steps of the above-described method of the present disclosure.
Alternatively, the present disclosure may also be embodied as a non-transitory machine-readable storage medium (or computer-readable storage medium, or machine-readable storage medium) having stored thereon executable code (or a computer program, or computer instruction code) that, when executed by a processor of an electronic device (or computing device, server, or the like), causes the processor to perform some or all of the various steps of the above-described method according to the present disclosure.
Those of skill would further appreciate that the various illustrative logical blocks, modules, circuits, and algorithm steps described in connection with the disclosure herein may be implemented as electronic hardware, computer software, or combinations of both.
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems and methods according to various embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
The foregoing description of the embodiments of the present disclosure has been presented for purposes of illustration and description, but is not intended to be exhaustive or limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen in order to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (4)
1. A biological sample freezing management processing method is characterized by comprising the following steps:
determining a liquid nitrogen tank for storing the frozen carrier;
selecting a preset distribution mode according to the liquid nitrogen tank;
distributing the storage positions of the frozen carriers loaded with the biological samples according to the selected non-cyclic incremental automatic distribution mode; and/or, dispensing a storage location for the frozen carrier loaded with the biological specimen according to a selected cyclical incremental automatic dispensing regime;
wherein, the said non-circulation increasing automatic distribution mode according to choosing, distribute the storage position of the frozen carrier loading biological sample, it is:
assigning a location for loading the frozen carrier with the biological specimen according to one or more of the following conditions:
the liquid nitrogen tank distinguishes the source of disease, uses empty positions in an increasing mode, the freezing carriers of the same patient have the same color, and the freezing carriers of different patients on the same bracket have different colors; or the like, or, alternatively,
the liquid nitrogen tank is used for storing freezing carriers of the same patient in different disease sources and in the same bracket; or the like, or, alternatively,
the liquid nitrogen tank distinguishes the sources of diseases, the freezing carriers of the same patient have the same color, and the freezing carriers of different patients on the same bracket have different colors; or the like, or, alternatively,
storing the patient frozen carrier in the empty position found first;
wherein, the automatic distribution mode is increased according to the selected cycle, the storage positions of the frozen carriers loaded with the biological samples are distributed as follows:
allocating storage locations for frozen carriers loaded with biological samples according to one or more of the following conditions:
the liquid nitrogen tank distinguishes the source of the disease, the color of the freezing carrier of the same couple is consistent, the positions of biological samples frozen by the patient on the same day are adjacent, and the adjacent empty positions are distributed to the patient when the circulation corresponding liquid nitrogen tank is newly distributed.
2. The method of claim 1, further comprising:
and displaying different visual interfaces for inventory management according to different categories of the liquid nitrogen tank, wherein the visual interfaces at least comprise inventory reminders.
3. The method of claim 1, further comprising:
searching and positioning the position of the freezing carrier corresponding to the patient through the acquired patient information; or the like, or, alternatively,
positioning the position of the freezing carrier corresponding to the patient by scanning a bar code, a two-dimensional code or an RFID electronic chip label associated with the same patient; or the like, or, alternatively,
and scanning the bar code, the two-dimensional code or the RFID electronic chip on the liquid nitrogen tank body or the inner pail or the support to acquire corresponding information of all patients.
4. The method of claim 1, further comprising:
before the freezing carrier loaded with the biological sample is placed in the liquid nitrogen tank, respectively scanning the freezing carrier and a bar code, a two-dimensional code or an RFID electronic chip label on the tank body of the liquid nitrogen tank or a lifting barrel or a support inside the liquid nitrogen tank for checking.
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| CN105956365A (en) * | 2016-04-20 | 2016-09-21 | 广东常青生命科学研究有限公司 | Method and system for managing biological sample |
| CN106056173A (en) * | 2016-05-23 | 2016-10-26 | 江苏省人民医院 | Biobank intelligent management system based on RFID and management method thereof |
| CN106295750B (en) * | 2016-08-18 | 2018-12-25 | 胡艳秋 | Embryo cryopreservation management control system based on vitro fertilization-embryo implanting |
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