CN113045855A - Thin film material for blocking ovarian interstitial tumor diffusion and preparation method thereof - Google Patents
Thin film material for blocking ovarian interstitial tumor diffusion and preparation method thereof Download PDFInfo
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- CN113045855A CN113045855A CN202110504009.6A CN202110504009A CN113045855A CN 113045855 A CN113045855 A CN 113045855A CN 202110504009 A CN202110504009 A CN 202110504009A CN 113045855 A CN113045855 A CN 113045855A
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- 239000000463 material Substances 0.000 title claims abstract description 83
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 68
- 230000002611 ovarian Effects 0.000 title claims abstract description 65
- 230000000903 blocking effect Effects 0.000 title claims abstract description 61
- 238000009792 diffusion process Methods 0.000 title claims abstract description 43
- 239000010409 thin film Substances 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title abstract description 29
- 239000002270 dispersing agent Substances 0.000 claims abstract description 140
- 229920005989 resin Polymers 0.000 claims abstract description 61
- 239000011347 resin Substances 0.000 claims abstract description 61
- -1 polypropylene Polymers 0.000 claims abstract description 44
- 239000004696 Poly ether ether ketone Substances 0.000 claims abstract description 41
- 239000004743 Polypropylene Substances 0.000 claims abstract description 41
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 41
- 229920002530 polyetherether ketone Polymers 0.000 claims abstract description 41
- 229920001155 polypropylene Polymers 0.000 claims abstract description 41
- 239000002994 raw material Substances 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000010408 film Substances 0.000 claims description 80
- 238000000034 method Methods 0.000 claims description 37
- 229920001661 Chitosan Polymers 0.000 claims description 24
- JOXIMZWYDAKGHI-UHFFFAOYSA-N p-toluenesulfonic acid Substances CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 22
- 239000003054 catalyst Substances 0.000 claims description 20
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 18
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 16
- 229920001911 maleic anhydride grafted polypropylene Polymers 0.000 claims description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 10
- 229930195725 Mannitol Natural products 0.000 claims description 10
- 235000019864 coconut oil Nutrition 0.000 claims description 10
- 239000003240 coconut oil Substances 0.000 claims description 10
- 239000000594 mannitol Substances 0.000 claims description 10
- 235000010355 mannitol Nutrition 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 229960000541 cetyl alcohol Drugs 0.000 claims description 8
- 239000000845 maltitol Substances 0.000 claims description 8
- 235000010449 maltitol Nutrition 0.000 claims description 8
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 8
- 229940035436 maltitol Drugs 0.000 claims description 8
- 239000001335 perilla frutescens leaf extract Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 3
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 125000005489 p-toluenesulfonic acid group Chemical group 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 35
- 239000012567 medical material Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 27
- 238000002156 mixing Methods 0.000 description 20
- 238000001125 extrusion Methods 0.000 description 10
- 238000005469 granulation Methods 0.000 description 10
- 230000003179 granulation Effects 0.000 description 10
- 210000001672 ovary Anatomy 0.000 description 6
- TXQVDVNAKHFQPP-UHFFFAOYSA-N [3-hydroxy-2,2-bis(hydroxymethyl)propyl] octadecanoate Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(CO)(CO)CO TXQVDVNAKHFQPP-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 206010027476 Metastases Diseases 0.000 description 3
- 230000035558 fertility Effects 0.000 description 3
- 230000009401 metastasis Effects 0.000 description 3
- 210000003101 oviduct Anatomy 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
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- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
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- 230000001568 sexual effect Effects 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000010096 film blowing Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000002710 gonadal effect Effects 0.000 description 1
- 210000000569 greater omentum Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/10—Homopolymers or copolymers of propene
- C08J2323/12—Polypropene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2361/00—Characterised by the use of condensation polymers of aldehydes or ketones; Derivatives of such polymers
- C08J2361/04—Condensation polymers of aldehydes or ketones with phenols only
- C08J2361/16—Condensation polymers of aldehydes or ketones with phenols only of ketones with phenols
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2423/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2423/10—Homopolymers or copolymers of propene
- C08J2423/12—Polypropene
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- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The invention relates to the technical field of medical material preparation, and particularly discloses a film material for blocking ovarian interstitial tumor diffusion and a preparation method thereof. The film material for blocking the ovarian interstitial tumor diffusion comprises the following raw material components in parts by weight: 50-80 parts of polyether-ether-ketone resin; 30-50 parts of polypropylene resin; 10-20 parts of a compatilizer; 10-20 parts of an antibacterial agent; 3-6 parts of a dispersing agent. The invention provides a film material with a brand-new composition for blocking ovarian interstitial tumor diffusion, and the film material also has excellent antibacterial performance.
Description
Technical Field
The invention relates to the technical field of medical material preparation, in particular to a film material for blocking ovarian interstitial tumor diffusion and a preparation method thereof.
Background
The ovarian solitary tumor is also called gonadal stromal tumor, which is tumor generated by granular cytoma, alveolar cytoma, fibroblast, supporting cell or stromal cell of sexual gland stroma source. It is well developed in women of childbearing age and postmenopausal women, and patients in the early stage with fertility requirements can be treated by the operation for keeping fertility. The common metastasis route of ovarian tumor is the implantation metastasis directly spreading to peripheral organs and the surfaces of omentum majus and organs in the pelvic cavity. Once a plant metastasis has occurred, the prognosis becomes markedly worse. In order to prevent the spreading of the ovarian funicular tumor, the inventor proposes a method for coating the ovary by a film bag, which can effectively prevent the spreading of the ovarian funicular tumor cells. The most common application ranges are: the ovary and the oviduct can be prevented from being wrapped by the people who have the non-sex cord interstitial tumor and perform the operation on the pelvic cavity; the healthy side ovary and the fallopian tube can be wrapped in the operation of a patient with the sexual interstitial tumor with the fertility function, so that the subsequent pregnancy is not influenced, and the healthy side ovary and the fallopian tube can be prevented from being transferred and scattered in the future if the tumor occurs; preventable use in patients with family history of ovarian and breast tumors; other applicable scenarios.
The inventor generally uses a film made of polyether ether ketone (PEEK) and/or polypropylene (PP) materials to wrap the ovary or the surgical wound at present in clinical practice; there is a lack of a membrane material specifically designed to wrap the ovaries.
Disclosure of Invention
In order to solve at least one technical problem in the prior art, the invention firstly provides a film material for blocking the ovarian funicular interstitial tumor diffusion.
The technical scheme for solving the technical problems is as follows:
a film material for blocking ovarian interstitial tumor diffusion comprises the following raw material components in parts by weight:
50-80 parts of polyether-ether-ketone resin; 30-50 parts of polypropylene resin; 10-20 parts of a compatilizer; 10-20 parts of an antibacterial agent; 3-6 parts of a dispersing agent.
Preferably, the film material for blocking the ovarian interstitial tumor diffusion comprises the following raw material components in parts by weight:
60-70 parts of polyether-ether-ketone resin; 35-40 parts of polypropylene resin; 10-15 parts of a compatilizer; 15-20 parts of an antibacterial agent; 3-5 parts of a dispersing agent.
Most preferably, the film material for blocking the ovarian interstitial tumor diffusion comprises the following raw material components in parts by weight:
60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer; 15 parts of an antibacterial agent; 5 parts of a dispersing agent.
Preferably, the compatilizer is maleic anhydride grafted polypropylene.
Preferably, the antimicrobial agent is chitosan.
Preferably, the dispersant consists of a dispersant A and a dispersant B; the mass ratio of the dispersing agent A to the dispersing agent B is 1-3: 1-2;
the dispersant A is prepared by the following method: taking 100-120 parts of coconut oil, then adding 40-50 parts of mannitol, 40-50 parts of sorbitol and 1-3 parts of catalyst, and reacting for 6-10 hours at 170-190 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: taking 120-150 parts of perilla seed oil, adding 75-90 parts of maltitol, 50-75 parts of palmityl alcohol and 1-5 parts of catalyst, and reacting at 135-150 ℃ for 6-10 hours in a nitrogen atmosphere to obtain the dispersant B.
Most preferably, the dispersant A is prepared by the following method: taking 100 parts of coconut oil, then adding 45 parts of mannitol, 45 parts of sorbitol and 2 parts of catalyst, and reacting for 8 hours at 180 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: and taking 130 parts of perilla seed oil, adding 85 parts of maltitol, 60 parts of palmityl alcohol and 3 parts of catalyst, and reacting for 8 hours at 140 ℃ in a nitrogen atmosphere to obtain the dispersant B.
Preferably, the catalyst is p-toluenesulfonic acid.
In order to increase the antibacterial capacity of the film material for blocking the ovarian funicular tumor diffusion, the antibacterial agent is added in the preparation process of the film material, so that the prepared film material for blocking the ovarian funicular tumor diffusion has an antibacterial effect. However, the antibacterial agent chitosan is simply added in the process of preparing the film material by taking polyether-ether-ketone and polypropylene as raw materials, so that the antibacterial agent chitosan can not exert excellent antibacterial performance, and the film material with excellent antibacterial performance can not be obtained. In order to enable the antibacterial agent chitosan to exert excellent antibacterial performance and obtain a film material with excellent antibacterial performance, the inventor surprisingly finds that the dispersant plays a decisive role in whether the antibacterial agent chitosan can exert excellent antibacterial performance or not in the process of preparing the film material by taking polyether-ether-ketone and polypropylene as raw materials. The conventional dispersing agent can not enable the antibacterial agent chitosan to exert excellent antibacterial performance so as to obtain a film material with excellent antibacterial performance; therefore, the inventor provides a dispersant consisting of the dispersants A and B prepared by the brand-new method; researches show that the conventional dispersing agent is replaced by the dispersing agent disclosed by the invention, so that the antibacterial agent chitosan can play an excellent antibacterial property in a film material prepared from polyether-ether-ketone and polypropylene serving as raw materials, and further the film material with more excellent antibacterial property can be prepared.
The invention also provides a preparation method of the film material for blocking the ovarian funiculous stromal tumor diffusion, which comprises the following steps:
after polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent are uniformly mixed, the mixture is melted and blended by a double-screw extruder, and the mixture is extruded and granulated to obtain the film material for blocking the ovarian interstitial tumor diffusion.
The invention also provides a film for blocking the ovarian funicular tumor diffusion, which is prepared from the film material for blocking the ovarian funicular tumor diffusion.
Preferably, the film material for blocking the ovarian interstitial tumor diffusion is also provided with holes with the aperture less than or equal to 10 um.
Preferably, the porous film means that at least 2 holes are formed on the film; the distance between adjacent holes is more than or equal to 1 time of the diameter of the holes.
Has the advantages that: the invention provides a film material with brand-new composition for blocking ovarian interstitial tumor diffusion; the film material is added with the antibacterial agent in the preparation process, so that the film material has antibacterial performance. Furthermore, in the process of preparing the film material by taking the polyether-ether-ketone and the polypropylene as raw materials, the dispersing agent formed by combining the dispersing agents A and B prepared by the brand-new method is added, and compared with the conventional dispersing agent, the dispersing agent can enable the antibacterial agent chitosan to exert excellent antibacterial performance in the film material prepared by taking the polyether-ether-ketone and the polypropylene as raw materials, so that the film material with more excellent antibacterial performance can be prepared. The film material has antibacterial performance, so that the film prepared from the film material and used for blocking the ovarian interstitial tumor diffusion has excellent antibacterial performance.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to limit the invention in any way.
The polyether-ether-ketone resin in the following examples is a 650G polyether-ether-ketone resin produced by Wedgess, UK; the polypropylene resin adopts polypropylene with the brand number of RB4404 produced by Korean oiling company; the remaining raw materials are conventional raw materials which can be purchased by those skilled in the art, unless otherwise specified.
Example 1 preparation of a thin film Material for blocking the spread of ovarian Soxhlet stromal tumors
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersing agent consists of a dispersing agent A and a dispersing agent B according to the mass ratio of 2: 1;
the dispersant A is prepared by the following method: taking 100 parts of coconut oil, then adding 45 parts of mannitol, 45 parts of sorbitol and 2 parts of catalyst p-toluenesulfonic acid, and reacting for 8 hours at 180 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: and taking 130 parts of perilla seed oil, adding 85 parts of maltitol, 60 parts of palmityl alcohol and 3 parts of catalyst p-toluenesulfonic acid, and reacting at 140 ℃ for 8 hours in a nitrogen atmosphere to obtain the dispersant B.
The preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
EXAMPLE 2 preparation of a film Material for blocking the spread of ovarian Soranostial tumors
The raw materials comprise the following components in parts by weight: 50 parts of polyether-ether-ketone resin; 50 parts of polypropylene resin; 20 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 10 parts of an antibacterial agent (specifically chitosan); 6 parts of a dispersing agent;
the dispersing agent consists of a dispersing agent A and a dispersing agent B according to the mass ratio of 3: 1;
the dispersant A is prepared by the following method: taking 120 parts of coconut oil, then adding 40 parts of mannitol, 40 parts of sorbitol and 1 part of catalyst p-toluenesulfonic acid, and reacting for 10 hours at 170 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: taking 150 parts of perilla seed oil, adding 75 parts of maltitol, 75 parts of palmityl alcohol and 2 parts of catalyst p-toluenesulfonic acid, and reacting at 135 ℃ for 10 hours in a nitrogen atmosphere to obtain the dispersant B.
The preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
EXAMPLE 3 preparation of film Material for blocking the spreading of ovarian Soranostial tumors
The raw materials comprise the following components in parts by weight: 80 parts of polyether-ether-ketone resin; 30 parts of polypropylene resin; 10 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 20 parts of an antibacterial agent (specifically chitosan); 3 parts of a dispersing agent;
the dispersing agent consists of a dispersing agent A and a dispersing agent B according to the mass ratio of 1: 2;
the dispersant A is prepared by the following method: taking 110 parts of coconut oil, then adding 50 parts of mannitol, 50 parts of sorbitol and 3 parts of catalyst p-toluenesulfonic acid, and reacting for 6 hours at 170 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: and taking 120 parts of perilla seed oil, adding 90 parts of maltitol, 50 parts of palmityl alcohol and 5 parts of catalyst p-toluenesulfonic acid, and reacting for 6 hours at 150 ℃ in a nitrogen atmosphere to obtain the dispersant B.
The preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
Comparative example 1 preparation of a film Material for blocking ovarian Soxhlet-stromal tumor spread
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan);
the preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer and an antibacterial agent into a mixer, uniformly mixing, then carrying out melt blending and extrusion granulation by a double-screw extruder.
Comparative example 1 differs from example 1 in that comparative example 1 does not have a dispersant added.
Comparative example 2 preparation of a film Material for blocking ovarian Soxhlet-interstitial tumor spread
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersant is sorbitan fatty acid ester;
the preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
Comparative example 2 differs from example 1 in that comparative example 2 employs a conventional sorbitan fatty acid ester as a dispersant; while example 1 used a dispersant prepared by a novel process.
Comparative example 3 preparation of a film Material for blocking the spreading of ovarian Soxhlet stromal tumors
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersing agent is pentaerythritol stearate;
the preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
Comparative example 3 differs from example 1 in that comparative example 3 employs a common pentaerythritol stearate as a dispersant; while example 1 used a dispersant prepared by a novel process.
Comparative example 4 preparation of film Material for blocking ovarian Soxhlet interstitial tumor spread
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersant is dispersant A;
the dispersant A is prepared by the following method: taking 100 parts of coconut oil, then adding 45 parts of mannitol, 45 parts of sorbitol and 2 parts of catalyst p-toluenesulfonic acid, and reacting for 8 hours at 180 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
Comparative example 4 is different from example 1 in that the dispersant described in comparative example 4 is only dispersant a prepared by a completely new method; the dispersant of example 1 consisted of dispersants A and B prepared in a completely new manner.
Comparative example 5 preparation of film Material for blocking ovarian Soxhlet interstitial tumor spread
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersant is dispersant B;
the dispersant B is prepared by the following method: and taking 130 parts of perilla seed oil, adding 85 parts of maltitol, 60 parts of palmityl alcohol and 3 parts of catalyst p-toluenesulfonic acid, and reacting at 140 ℃ for 8 hours in a nitrogen atmosphere to obtain the dispersant B.
The preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
Comparative example 5 is different from example 1 in that the dispersant described in comparative example 5 is only dispersant B prepared by a brand new method; the dispersant of example 1 consisted of dispersants A and B prepared in a completely new manner.
Comparative example 6 preparation of film Material for blocking ovarian Soxhlet interstitial tumor spread
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersing agent consists of a dispersing agent A and a dispersing agent B according to the mass ratio of 2: 1;
the dispersant A is prepared by the following method: taking 100 parts of coconut oil, then adding 45 parts of mannitol, 45 parts of sorbitol and 2 parts of catalyst p-toluenesulfonic acid, and reacting for 8 hours at 180 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is sorbitan fatty acid ester.
The preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
The difference between the comparative example 6 and the example 1 is that the dispersant in the comparative example 4 is composed of the dispersant A prepared by a brand-new method and sorbitan fatty acid ester which is a conventional dispersant; the dispersant of example 1 consisted of dispersants A and B prepared in a completely new manner.
Comparative example 7 preparation of film Material for blocking ovarian Soxhlet interstitial tumor spread
The raw materials comprise the following components in parts by weight: 60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer (specifically maleic anhydride grafted polypropylene); 15 parts of an antibacterial agent (specifically chitosan); 5 parts of a dispersing agent;
the dispersing agent consists of a dispersing agent A and a dispersing agent B according to the mass ratio of 2: 1;
the dispersant A is prepared by the following method: taking 100 parts of coconut oil, then adding 45 parts of mannitol, 45 parts of sorbitol and 2 parts of catalyst p-toluenesulfonic acid, and reacting for 8 hours at 180 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is pentaerythritol stearate.
The preparation method comprises the following steps: the film material for blocking the ovarian interstitial tumor diffusion is prepared by putting polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent into a mixer, uniformly mixing, then carrying out melt blending by a double-screw extruder, and carrying out extrusion granulation.
The difference between the comparative example 7 and the example 1 is that the dispersant in the comparative example 7 is composed of a dispersant A prepared by a brand-new method and a conventional dispersant pentaerythritol stearate; the dispersant of example 1 consisted of dispersants A and B prepared in a completely new manner.
Experimental example 1
Preparing the film material for blocking ovarian interstitial tumor diffusion, which is prepared in the examples 1-3 and the comparative examples 1-7, into a film by a plastic film blowing machine; and detecting the antibacterial effect of the film material for blocking the ovarian interstitial tumor diffusion on escherichia coli and staphylococcus aureus.
The method for testing the antibacterial effect comprises the following steps: spreading a film made of the film material for blocking the ovarian funicular tumor diffusion prepared in the embodiments 1-3 and the comparative examples 1-6 in a culture dish, then coating a culture medium containing the same number of living colonies on the film, then putting the culture dish in an incubator for storage, calculating the number of the colonies after 24 hours, and calculating the bacteriostasis rate; the higher the bacteriostasis rate is, the better the bacteriostasis effect of the film material for blocking the ovarian interstitial tumor diffusion is.
The inhibition ratio (number of original colonies-number of colonies after 24 hours)/number of original colonies) x 100%
TABLE 1 results of experiment on antibacterial effect of thin film material for blocking ovarian interstitial tumor diffusion
As can be seen from the data in table 1, the inhibition rate of the film material for blocking ovarian funicular tumor diffusion prepared in examples 1 to 3 on escherichia coli and staphylococcus aureus can reach more than 98%, which indicates that the film material for blocking ovarian funicular tumor diffusion prepared by the present invention has an excellent antibacterial effect.
As can be seen from the data in table 1, the antibacterial rate of the film material for blocking ovarian interstitial tumor diffusion prepared in comparative example 1 is less than that of example 1 and comparative examples 2 to 7; this indicates that: in the process of preparing the film material by taking polyether-ether-ketone and polypropylene as raw materials, the addition of the dispersing agent can promote the antibacterial agent chitosan to further exert antibacterial performance.
As can be seen from the data in table 1, the antibacterial rate of the film materials for blocking the ovarian interstitial tumor diffusion prepared in comparative examples 2 and 3 is much lower than that of example 1, which indicates that the conventional dispersing agent can not make the antibacterial agent chitosan exert excellent antibacterial performance so as to obtain the film material with excellent antibacterial performance; compared with the conventional dispersing agent, the dispersing agent consisting of the dispersing agents A and B prepared by the brand new method can enable the antibacterial agent chitosan to exert more excellent antibacterial performance in the film material prepared from the polyether-ether-ketone and the polypropylene as raw materials, and further can prepare the film material with more excellent antibacterial performance.
As can be seen from the data in table 1, the antibacterial rate of the film material for blocking ovarian interstitial tumor diffusion prepared in comparative examples 4 to 7 is far less than that of example 1, which shows that: the dispersant A or the dispersant B prepared by the brand-new method is independently used; or the dispersant A or B prepared by the brand-new method is combined with the conventional dispersant, so that the antibacterial chitosan can not exert excellent antibacterial performance to obtain a film material with excellent antibacterial performance; only by adopting the dispersing agent consisting of the dispersing agents A and B prepared by the brand new method, the antibacterial chitosan can exert more excellent antibacterial performance in the film material prepared by taking polyether-ether-ketone and polypropylene as raw materials, and the film material with more excellent antibacterial performance can be prepared.
Claims (10)
1. A film material for blocking ovarian interstitial tumor diffusion is characterized by comprising the following raw material components in parts by weight:
50-80 parts of polyether-ether-ketone resin; 30-50 parts of polypropylene resin; 10-20 parts of a compatilizer; 10-20 parts of an antibacterial agent; 3-6 parts of a dispersing agent.
2. The film material for blocking the ovarian funicular tumor diffusion according to claim 1, is characterized by comprising the following raw material components in parts by weight:
60-70 parts of polyether-ether-ketone resin; 35-40 parts of polypropylene resin; 10-15 parts of a compatilizer; 15-20 parts of an antibacterial agent; 3-5 parts of a dispersing agent.
3. The film material for blocking the ovarian funicular tumor diffusion according to claim 1, is characterized by comprising the following raw material components in parts by weight:
60 parts of polyether-ether-ketone resin; 40 parts of polypropylene resin; 15 parts of a compatilizer; 15 parts of an antibacterial agent; 5 parts of a dispersing agent.
4. The film material for blocking the spread of an ovarian funicular tumor according to claim 1, wherein the compatilizer is maleic anhydride grafted polypropylene.
5. The membrane material for blocking the spread of ovarian funicular tumors according to claim 1, wherein the antimicrobial agent is chitosan.
6. The film material for blocking the ovarian funicular tumor spreading according to claim 1, wherein the dispersing agent is composed of dispersing agent A and dispersing agent B; the mass ratio of the dispersing agent A to the dispersing agent B is 1-3: 1-2;
the dispersant A is prepared by the following method: taking 100-120 parts of coconut oil, then adding 40-50 parts of mannitol, 40-50 parts of sorbitol and 1-3 parts of catalyst, and reacting for 6-10 hours at 170-190 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: taking 120-150 parts of perilla seed oil, adding 75-90 parts of maltitol, 50-75 parts of palmityl alcohol and 1-5 parts of catalyst, and reacting at 135-150 ℃ for 6-10 hours in a nitrogen atmosphere to obtain the dispersant B.
7. The thin film material for blocking the spread of ovarian funicular tumor according to claim 1,
the dispersant A is prepared by the following method: taking 100 parts of coconut oil, then adding 45 parts of mannitol, 45 parts of sorbitol and 2 parts of catalyst, and reacting for 8 hours at 180 ℃ in a nitrogen atmosphere to obtain a dispersant A;
the dispersant B is prepared by the following method: and taking 130 parts of perilla seed oil, adding 85 parts of maltitol, 60 parts of palmityl alcohol and 3 parts of catalyst, and reacting for 8 hours at 140 ℃ in a nitrogen atmosphere to obtain the dispersant B.
8. The membrane material for blocking the spread of ovarian funicular tumors according to claim 1, wherein the catalyst is p-toluenesulfonic acid.
9. The method for preparing the film material for blocking the ovarian funicular tumor spreading according to any one of claims 1-8, characterized by comprising the following steps:
after polyether-ether-ketone resin, polypropylene resin, a compatilizer, an antibacterial agent and a dispersing agent are uniformly mixed, the mixture is melted and blended by a double-screw extruder, and the mixture is extruded and granulated to obtain the film material for blocking the ovarian interstitial tumor diffusion.
10. A film for blocking ovarian funicular tumor spread, which is prepared from the film material for blocking ovarian funicular tumor spread according to any one of claims 1-8.
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