CN113042040B - Method for preparing tranexamic acid by using platinum-carbon catalyst - Google Patents
Method for preparing tranexamic acid by using platinum-carbon catalyst Download PDFInfo
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Abstract
The invention discloses a platinum-carbon catalyst and a method for preparing tranexamic acid by using the platinum-carbon catalyst, wherein active carbon, water, hydrochloric acid, chloroplatinic acid and ethylene glycol are used for preparing the platinum-carbon catalyst; then adding the prepared platinum-carbon catalyst, p-aminomethylbenzoic acid, pure water and concentrated sulfuric acid into a hydrogenation kettle for catalytic hydrogenation reaction to prepare tranexamic acid, wherein the reaction conditions are 20-25 ℃, 0.2MPa and the time is 1-1.5 h; and the catalytic hydrogenation reaction is carried out at room temperature without heating, and the reaction condition is milder.
Description
Technical Field
The invention belongs to the technical field of tranexamic acid preparation, and relates to a method for preparing tranexamic acid by using a platinum carbon catalyst.
Background
Tranexamic acid (Tranexamic acid), also known as Tranexamic acid, and its molecular formula C 8 H 15 NO 2 The chemical name is trans-4-aminomethyl cyclohexane carboxylic acid which can be used effectively for dissolving fibrinogen by blocking the reversibility of lysine bound to plasminogen moleculeBleeding is a widely used condition, and is commonly used for respiratory tract, digestive tract bleeding, surgical bleeding, etc.
At present, the industrial preparation of tranexamic acid mainly by taking para-aminomethylbenzoic acid as a main raw material, and the catalytic hydrogenation of the para-aminomethylbenzoic acid is an important step in the synthetic route. In the step, platinum dioxide is generally used as a catalyst for catalytic hydrogenation, the proportion of the para-aminomethylbenzoic acid to the platinum dioxide=1:0.05, the hydrogenation temperature is about 40 ℃, and the hydrogen pressure is 0.5-1.5kg/cm 2 . The method has the problems of large metal platinum consumption and large reaction pressure.
In addition, the method for producing tranexamic acid disclosed in the publication CN1524847a, wherein Pt-M/C (m= Ru, la, ce, co or Ni) catalyst is used; a process for the preparation of 4-aminomethylcyclohexane carboxylic acid-1, disclosed in publication No. US3932497, wherein 1-10% ru supported catalyst is used; a process for the preparation of 4-aminomethylcyclohexane carboxylic acid or an inorganic acid salt thereof as disclosed in GB2084145A, wherein a mixed (5% Pd/C,5% Pt/C,5% Rh/C) catalyst is used. However, these supported catalysts also have problems in that the amount of noble metal used is large or the reaction conditions are not gentle enough.
Disclosure of Invention
Aiming at the problems, the invention provides a method for preparing tranexamic acid by using a platinum-carbon catalyst, which well solves the problems of large catalyst consumption and large reaction pressure of the catalytic hydrogenation reaction of the p-aminomethylbenzoic acid in the prior art.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a platinum carbon catalyst is prepared by the following steps:
(1) Simultaneously placing the activated carbon and water with the mass 5 times of that of the activated carbon into a container, and sequentially heating, boiling, cooling and filtering to obtain clean activated carbon;
(2) Adding 1mol/L hydrochloric acid which is 5 times of the activated carbon and the clean activated carbon prepared in the step (1) into a container at the same time, stirring, filtering, drying and cooling to room temperature, and then adding ethylene glycol which is 30 times of the activated carbon into the container at the same time to obtain a mixture A;
(3) Dissolving 1/5-1/2.83 of chloroplatinic acid in ethylene glycol with the mass of 8 times of that of the chloroplatinic acid to obtain 10% ethylene glycol solution of chloroplatinic acid, adding the 10% ethylene glycol solution of chloroplatinic acid into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) And (3) adding 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then carrying out heating reflux, cooling and filtering to obtain a filter product C, and washing the filter product C with water to obtain the platinum carbon catalyst.
Further, the boiling time in the step (1) is 1h; stirring time in the step (2) is 4 hours, and drying temperature is 80 ℃; the heating reflux time in the step (4) is 2h.
Further, the mass of the chloroplatinic acid is 1/3.39 of the mass of the activated carbon.
The invention also provides a method for preparing tranexamic acid, which uses the platinum-carbon catalyst prepared according to the method, and comprises the following steps:
s1: sequentially adding a platinum-carbon catalyst, p-aminomethylbenzoic acid, pure water and concentrated sulfuric acid into a hydrogenation kettle according to the mass ratio of 0.025-0.075:1:30:0.4;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen, then replacing nitrogen in the hydrogenation kettle with hydrogen, regulating the pressure of the hydrogen to 0.2MPa, and reacting for 1-1.5h at the reaction temperature of 20-25 ℃ in the hydrogenation kettle to generate p-aminomethyl cyclohexane carboxylic acid to obtain hydrogenation reaction liquid;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 1/3 of the original volume, adding barium hydroxide with the mass being 2 times that of the para-aminomethylbenzoic acid, carrying out configuration conversion in a hydrogenation kettle, cooling to room temperature, and filtering to obtain a mother liquid D;
s4: concentrating the mother solution D in the step S3 to 1/6 of the hydrogenation reaction liquid obtained in the step S2, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain a refined tranexamic acid product.
Further, in the step S1, the mass ratio of the platinum-carbon catalyst to the para-aminomethylbenzoic acid to the pure water to the concentrated sulfuric acid is 0.05:1:30:0.4.
Further, the configuration conversion condition in the step S3 is 220 ℃, 2.0-2.5MPa, and the reaction time is 2h.
Further, the filtering mode in the step S3 and the step S4 adopts centrifugal throwing filtration.
Further, in step S2, the number of times of replacing the air in the hydrogenation reactor with nitrogen and replacing the nitrogen in the hydrogenation reactor with hydrogen was 2.
Compared with the prior art, the invention has the following beneficial effects:
in the invention, platinum in the platinum-carbon catalyst is used as single noble metal, and is easier to recycle compared with a composite catalyst;
in the invention, the activated carbon in the platinum-carbon catalyst is used as a carrier, and is activated by water and acid treatment before platinum metal is loaded, so that the adsorption efficiency of the activated carbon is improved, and the catalytic effect of the platinum-carbon catalyst is further improved;
in the invention, the ethylene glycol can be used as a solvent and a reducing agent for reducing chloroplatinic acid at the same time, and the ethylene glycol after the reaction can be recovered and reused, so that the resource is saved;
in the invention, the platinum content in the prepared platinum-carbon catalyst is 6.9-12%, and when the platinum-carbon catalyst is used for preparing tranexamic acid, compared with the feeding quality of p-aminomethylbenzoic acid, the platinum metal dosage in the catalytic hydrogenation reaction is reduced; and when the mass of chloroplatinic acid is 1/3.39 of the mass of the active carbon, the content of the prepared platinum-carbon catalyst is 10 percent, and the catalytic efficiency is highest.
In the invention, the pressure of the catalytic hydrogenation reaction is 0.2MPa, the reaction temperature is 20-25 ℃, the reaction time is 1-1.5h, the reaction is carried out at room temperature, no heating is needed, and the reaction condition is milder.
Drawings
FIG. 1 is a high performance liquid chromatogram of tranexamic acid obtained in example I of the present invention;
FIG. 2 is a high performance liquid chromatogram of tranexamic acid obtained in example two of the present invention;
FIG. 3 is a high performance liquid chromatogram of tranexamic acid obtained in example III of the invention;
FIG. 4 is a high performance liquid chromatogram of tranexamic acid obtained in example IV of the invention;
FIG. 5 is a high performance liquid chromatogram of tranexamic acid obtained in example five of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The preparation method of the platinum-carbon catalyst comprises the following steps:
(1) 5 g of active carbon and 25 ml of water are simultaneously put into a container, and are heated, boiled, cooled and filtered in sequence to obtain clean active carbon;
(2) Adding 25 ml of 1mol/L hydrochloric acid and the clean activated carbon prepared in the step (1) into a container at the same time, stirring for 4 hours, filtering, drying at 80 ℃, cooling to room temperature, and adding 150 ml of ethylene glycol into the container at the same time to obtain a mixture A;
(3) Dissolving 1 g of chloroplatinic acid in 8 ml of ethylene glycol to obtain a 10% ethylene glycol chloroplatinic acid solution, adding the 10% ethylene glycol chloroplatinic acid solution into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) And (3) dropwise adding a 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then heating and refluxing for 2h, cooling and filtering to obtain a filter product C, and washing the filter product C with water to obtain a wet platinum-carbon catalyst for later use, wherein the platinum content is 6.9%.
Followed by the preparation of tranexamic acid comprising the steps of:
s1: sequentially adding the platinum-carbon catalyst prepared in the step (4), 200 g of p-aminomethylbenzoic acid, 6L of pure water and 80 ml of concentrated sulfuric acid into a hydrogenation kettle, and uniformly stirring;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen for 2 times, then replacing nitrogen in the hydrogenation kettle with hydrogen for 2 times, regulating the pressure of the hydrogen to 0.2MPa, reacting for 1.5 hours at the reaction temperature of 20-25 ℃ in the hydrogenation kettle to generate p-aminomethylcyclohexane carboxylic acid, and filtering to obtain hydrogenation reaction liquid, wherein no p-aminomethylbenzoic acid residue exists in a reaction system;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 2 liters, adding 400 g of barium hydroxide, carrying out configuration conversion for 2 hours under the conditions of 220 ℃ and 2.0-2.5MPa in a hydrogenation kettle, cooling to room temperature, and filtering to obtain mother liquid D;
s4: concentrating the mother solution D in the step S3 to 1 liter, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain 142 g of refined tranexamic acid product. As shown in fig. 1, the purity was greater than 99%. The data in fig. 1 are given in the following table:
| retention time/min | Peak area/mAU x S | Peak height/mAU | Symmetry factor | Peak width/min | Number of trays |
| 13.022 | 716.74097 | 37.91673 | 0.69 | 0.2866 | 11421 |
Example two
The preparation method of the platinum-carbon catalyst comprises the following steps:
(1) 100 g of active carbon and 500 ml of water are simultaneously put into a container, and are heated, boiled, cooled and filtered in sequence to obtain clean active carbon;
(2) Adding 500 ml of 1mol/L hydrochloric acid and the clean activated carbon prepared in the step (1) into a container at the same time, stirring for 4 hours, filtering, drying at 80 ℃, cooling to room temperature, and adding 3 liters of ethylene glycol into the container at the same time to obtain a mixture A;
(3) Dissolving 35.33 g of chloroplatinic acid in 282.7 ml of ethylene glycol to obtain a 10% ethylene glycol chloroplatinic acid solution, adding the 10% ethylene glycol chloroplatinic acid solution into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) And (3) dropwise adding a 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then heating and refluxing for 2h, cooling and filtering to obtain a filter product C, and washing the filter product C with water to obtain a wet platinum-carbon catalyst for later use, wherein the platinum content is 12%.
Followed by the preparation of tranexamic acid comprising the steps of:
s1: sequentially adding the platinum-carbon catalyst prepared in the step (4), 4 kg of p-aminomethylbenzoic acid, 120L of pure water and 1.6L of concentrated sulfuric acid into a hydrogenation kettle, and uniformly stirring;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen for 2 times, then replacing nitrogen in the hydrogenation kettle with hydrogen for 2 times, regulating the pressure of the hydrogen to 0.2MPa, reacting for 1.2 hours at the reaction temperature of 20-25 ℃ in the hydrogenation kettle to generate p-aminomethylcyclohexane carboxylic acid, and filtering to obtain hydrogenation reaction liquid, wherein no p-aminomethylbenzoic acid residue exists in a reaction system;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 50 liters, adding 8 kg of barium hydroxide, carrying out configuration conversion for 2 hours under the conditions of 220 ℃ and 2.0-2.5MPa in a hydrogenation kettle, cooling to room temperature, and filtering to obtain mother liquid D;
s4: concentrating the mother liquor D in the step S3 to 25 liters, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain 3.1 kg of refined tranexamic acid product. As shown in fig. 2, the purity was greater than 99%. The data in fig. 2 are shown in the following table:
| retention time/min | Peak area/mAU x S | Peak height/mAU | Symmetry factor | Peak width/min | Number of trays |
| 13.033 | 720.56598 | 38.18181 | 0.69 | 0.2855 | 11534 |
Example III
The preparation method of the platinum-carbon catalyst comprises the following steps:
(1) Putting 500 g of active carbon and 2.5L of water into a container at the same time, and sequentially heating, boiling, cooling and filtering to obtain clean active carbon;
(2) Adding 2.5L of 1mol/L hydrochloric acid and the clean activated carbon prepared in the step (1) into a container at the same time, stirring for 4 hours, filtering, drying at 80 ℃, cooling to room temperature, and adding 15L of ethylene glycol into the container at the same time to obtain a mixture A;
(3) Dissolving 147.5 g of chloroplatinic acid in 1.18L of ethylene glycol to obtain a 10% ethylene glycol chloroplatinic acid solution, adding the 10% ethylene glycol chloroplatinic acid solution into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) And (3) dropwise adding a 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then heating and refluxing for 2h, cooling and filtering to obtain a filter product C, and washing the filter product C with water to obtain a wet platinum-carbon catalyst for later use, wherein the platinum content is 10%.
Followed by the preparation of tranexamic acid comprising the steps of:
s1: sequentially adding the platinum-carbon catalyst prepared in the step (4), 20 kg of p-aminomethylbenzoic acid, 600L of pure water and 8L of concentrated sulfuric acid into a hydrogenation kettle, and uniformly stirring;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen for 2 times, then replacing nitrogen in the hydrogenation kettle with hydrogen for 2 times, regulating the pressure of the hydrogen to 0.2MPa, reacting for 1h at 20-25 ℃ in the hydrogenation kettle to generate p-aminomethylcyclohexane carboxylic acid, and filtering to obtain hydrogenation reaction liquid, wherein no p-aminomethylbenzoic acid residue exists in a reaction system;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 200 liters, adding 40 kg of barium hydroxide, carrying out configuration conversion for 2 hours under the conditions of 220 ℃ and 2.0-2.5MPa in a hydrogenation kettle, cooling to room temperature, and filtering to obtain mother liquid D;
s4: concentrating the mother solution D in the step S3 to 100 liters, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain 15.6 kg of refined tranexamic acid product. As shown in fig. 3, the purity was greater than 99%. The data in fig. 3 are shown in the following table:
| retention time/min | Peak area/mAU x S | Peak height/mAU | Symmetry factor | Peak width/min | Number of trays |
| 13.031 | 717.61243 | 38.15605 | 0.69 | 0.2848 | 11584 |
Example IV
The preparation method of the platinum-carbon catalyst comprises the following steps:
(1) 7.5 g of active carbon and 37.5 ml of water are simultaneously put into a container, and are sequentially heated, boiled, cooled and filtered to obtain clean active carbon;
(2) Adding 37.5 ml of 1mol/L hydrochloric acid and the clean activated carbon prepared in the step (1) into a container at the same time, stirring for 4 hours, filtering, drying at 80 ℃, cooling to room temperature, and adding 225 ml of ethylene glycol into the container at the same time to obtain a mixture A;
(3) Dissolving 1.5 g of chloroplatinic acid in 12 ml of ethylene glycol to obtain a 10% ethylene glycol solution, adding the 10% ethylene glycol solution into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) And (3) dropwise adding a 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then heating and refluxing for 2h, cooling and filtering to obtain a filter product C, and washing the filter product C with water to obtain a wet platinum-carbon catalyst for later use, wherein the platinum content is 6.9%.
Followed by the preparation of tranexamic acid comprising the steps of:
s1: sequentially adding the platinum-carbon catalyst prepared in the step (4), 200 g of p-aminomethylbenzoic acid, 6L of pure water and 80 ml of concentrated sulfuric acid into a hydrogenation kettle, and uniformly stirring;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen for 2 times, then replacing nitrogen in the hydrogenation kettle with hydrogen for 2 times, regulating the pressure of the hydrogen to 0.2MPa, reacting for 1.5 hours at the reaction temperature of 20-25 ℃ in the hydrogenation kettle to generate p-aminomethylcyclohexane carboxylic acid, and filtering to obtain hydrogenation reaction liquid, wherein no p-aminomethylbenzoic acid residue exists in a reaction system;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 2 liters, adding 400 g of barium hydroxide, carrying out configuration conversion for 2 hours under the conditions of 220 ℃ and 2.0-2.5MPa in a hydrogenation kettle, cooling to room temperature, and filtering to obtain mother liquid D;
s4: concentrating the mother solution D in the step S3 to 1 liter, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain 146 g of refined tranexamic acid product. As shown in fig. 3, the purity was greater than 99%. The data in fig. 3 are shown in the following table:
| retention time/min | Peak area/mAU x S | Peak height/mAU | Symmetry factor | Peak width/min | Number of trays |
| 13.027 | 717.28210 | 38.17296 | 0.69 | 0.2853 | 11536 |
Example five
The preparation method of the platinum-carbon catalyst comprises the following steps:
(1) 2.5 g of active carbon and 12.5 ml of water are simultaneously put into a container, and are heated, boiled, cooled and filtered in sequence to obtain clean active carbon;
(2) Adding 12.5 ml of 1mol/L hydrochloric acid and the clean activated carbon prepared in the step (1) into a container at the same time, stirring for 4 hours, filtering, drying at 80 ℃, cooling to room temperature, and adding 75 ml of ethylene glycol into the container at the same time to obtain a mixture A;
(3) Dissolving 0.5 g of chloroplatinic acid in 4 ml of ethylene glycol to obtain a 10% ethylene glycol solution, adding the 10% ethylene glycol solution into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) And (3) dropwise adding a 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then heating and refluxing for 2h, cooling and filtering to obtain a filter product C, and washing the filter product C with water to obtain a wet platinum-carbon catalyst for later use, wherein the platinum content is 6.9%.
Followed by the preparation of tranexamic acid comprising the steps of:
s1: sequentially adding the platinum-carbon catalyst prepared in the step (4), 200 g of p-aminomethylbenzoic acid, 6L of pure water and 80 ml of concentrated sulfuric acid into a hydrogenation kettle, and uniformly stirring;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen for 2 times, then replacing nitrogen in the hydrogenation kettle with hydrogen for 2 times, regulating the pressure of the hydrogen to 0.2MPa, reacting for 1.5 hours at the reaction temperature of 20-25 ℃ in the hydrogenation kettle to generate p-aminomethylcyclohexane carboxylic acid, and filtering to obtain hydrogenation reaction liquid, wherein no p-aminomethylbenzoic acid residue exists in a reaction system;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 2 liters, adding 400 g of barium hydroxide, carrying out configuration conversion for 2 hours under the conditions of 220 ℃ and 2.0-2.5MPa in a hydrogenation kettle, cooling to room temperature, and filtering to obtain mother liquid D;
s4: concentrating the mother solution D in the step S3 to 1 liter, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain 146 g of refined tranexamic acid product. As shown in fig. 5, the purity was greater than 99%. The data in fig. 5 are as follows:
| retention time/min | Peak area/mAU x S | Peak height/mAU | Symmetry factor | Peak width/min | Number of trays |
| 13.024 | 719.09991 | 38.02558 | 0.69 | 0.2861 | 11470 |
Although the present invention has been described with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements and changes may be made without departing from the spirit and principles of the present invention.
Claims (7)
1. A method for preparing tranexamic acid by using a platinum carbon catalyst, which is characterized in that: the preparation method of the platinum carbon catalyst comprises the following steps:
(1) Simultaneously placing the activated carbon and water with the mass 5 times of that of the activated carbon into a container, and sequentially heating, boiling, cooling and filtering to obtain clean activated carbon;
(2) Adding 1mol/L hydrochloric acid which is 5 times of the activated carbon and the clean activated carbon prepared in the step (1) into a container at the same time, stirring, filtering, drying and cooling to room temperature, and then adding ethylene glycol which is 30 times of the activated carbon into the container at the same time to obtain a mixture A;
(3) Dissolving 1/5-1/2.83 of chloroplatinic acid in ethylene glycol with the mass of 8 times of that of the chloroplatinic acid to obtain 10% ethylene glycol solution of chloroplatinic acid, adding the 10% ethylene glycol solution of chloroplatinic acid into the mixture A obtained in the step (2), and uniformly stirring to obtain a mixture B;
(4) Adding 1mol/L sodium hydroxide glycol solution into the mixture B in the step (3), regulating the pH value of the mixture B to 9-10, then carrying out heating reflux, cooling and filtering to obtain a filter product C, washing the filter product C with water to obtain a platinum-carbon catalyst, wherein the platinum content of the obtained platinum-carbon catalyst is 6.9% -12%;
the procedure for the preparation of tranexamic acid using the platinum carbon catalyst prepared in step (4) is described as follows:
s1: sequentially adding a platinum-carbon catalyst, p-aminomethylbenzoic acid, pure water and concentrated sulfuric acid into a hydrogenation kettle according to the mass ratio of 0.025-0.075:1:30:0.4;
s2: firstly, replacing air in a hydrogenation kettle with nitrogen, then replacing nitrogen in the hydrogenation kettle with hydrogen, regulating the pressure of the hydrogen to 0.2MPa, and reacting for 1-1.5h at the reaction temperature of 20-25 ℃ in the hydrogenation kettle to generate p-aminomethyl cyclohexane carboxylic acid to obtain hydrogenation reaction liquid;
s3: concentrating the hydrogenation reaction liquid obtained in the step S2 to 1/3 of the original volume, adding barium hydroxide with the mass being 2 times that of the para-aminomethylbenzoic acid, carrying out configuration conversion in a hydrogenation kettle, cooling to room temperature, and filtering to obtain a mother liquid D;
s4: concentrating the mother solution D in the step S3 to 1/6 of the hydrogenation reaction liquid obtained in the step S2, cooling to room temperature, and filtering to obtain a crude product of tranexamic acid;
s5: and (3) recrystallizing the crude tranexamic acid product obtained in the step (S4) with water, and drying to obtain a refined tranexamic acid product.
2. The method for producing tranexamic acid with a platinum carbon catalyst according to claim 1, wherein: the boiling time in the step (1) is 1h; stirring time in the step (2) is 4 hours, and drying temperature is 80 ℃; the heating reflux time in the step (4) is 2h.
3. The method for producing tranexamic acid with a platinum carbon catalyst according to claim 1, wherein: the mass of the chloroplatinic acid is 1/3.39 of the mass of the activated carbon.
4. A method for preparing tranexamic acid with a platinum carbon catalyst according to claim 3, wherein: in the step S1, the mass ratio of the platinum carbon catalyst to the para-aminomethylbenzoic acid to the pure water to the concentrated sulfuric acid is 0.05:1:30:0.4.
5. A method for preparing tranexamic acid with a platinum carbon catalyst according to claim 3, wherein: the configuration conversion condition in the step S3 is 220 ℃, 2.0-2.5MPa, and the reaction time is 2h.
6. A method for preparing tranexamic acid with a platinum carbon catalyst according to claim 3, wherein: the filtering mode in the step S3 and the step S4 adopts centrifugal throwing filtration.
7. A method for preparing tranexamic acid with a platinum carbon catalyst according to claim 3, wherein: in the step S2, the times of replacing the air in the hydrogenation kettle with nitrogen and replacing the nitrogen in the hydrogenation kettle with hydrogen are 2 times.
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