CN113041023A - Anti-adhesion healing-promoting alginate dressing and preparation method thereof - Google Patents
Anti-adhesion healing-promoting alginate dressing and preparation method thereof Download PDFInfo
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- CN113041023A CN113041023A CN202110272031.2A CN202110272031A CN113041023A CN 113041023 A CN113041023 A CN 113041023A CN 202110272031 A CN202110272031 A CN 202110272031A CN 113041023 A CN113041023 A CN 113041023A
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- 235000010443 alginic acid Nutrition 0.000 title claims abstract description 76
- 229920000615 alginic acid Polymers 0.000 title claims abstract description 76
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 title claims abstract description 73
- 229940072056 alginate Drugs 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 64
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 239000011505 plaster Substances 0.000 claims abstract description 15
- 230000035876 healing Effects 0.000 claims abstract description 11
- 239000002674 ointment Substances 0.000 claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 238000000265 homogenisation Methods 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 20
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 15
- 229920002674 hyaluronan Polymers 0.000 claims description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 239000002562 thickening agent Substances 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 229920001661 Chitosan Polymers 0.000 claims description 11
- 102000008186 Collagen Human genes 0.000 claims description 11
- 108010035532 Collagen Proteins 0.000 claims description 11
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 11
- 229920001436 collagen Polymers 0.000 claims description 11
- 239000003292 glue Substances 0.000 claims description 11
- 239000000839 emulsion Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000013521 mastic Substances 0.000 claims description 7
- 244000215068 Acacia senegal Species 0.000 claims description 6
- 229920000084 Gum arabic Polymers 0.000 claims description 6
- 235000010489 acacia gum Nutrition 0.000 claims description 6
- 239000000205 acacia gum Substances 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 238000009833 condensation Methods 0.000 claims description 5
- 230000005494 condensation Effects 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 5
- 238000009958 sewing Methods 0.000 claims description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 239000000783 alginic acid Substances 0.000 claims description 3
- 229960001126 alginic acid Drugs 0.000 claims description 3
- 150000004781 alginic acids Chemical class 0.000 claims description 3
- 235000010410 calcium alginate Nutrition 0.000 claims description 3
- 239000000648 calcium alginate Substances 0.000 claims description 3
- 229960002681 calcium alginate Drugs 0.000 claims description 3
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 235000010408 potassium alginate Nutrition 0.000 claims description 3
- 239000000737 potassium alginate Substances 0.000 claims description 3
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 1
- 239000002699 waste material Substances 0.000 abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 description 34
- 206010052428 Wound Diseases 0.000 description 32
- 230000000694 effects Effects 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 235000003717 Boswellia sacra Nutrition 0.000 description 3
- 240000007551 Boswellia serrata Species 0.000 description 3
- 235000012035 Boswellia serrata Nutrition 0.000 description 3
- 239000004863 Frankincense Substances 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000037237 body shape Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241001474374 Blennius Species 0.000 description 1
- 206010053692 Wound complication Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- -1 polysaccharide carbohydrate Chemical class 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0269—Tapes for dressing attachment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0273—Adhesive bandages for winding around limb, trunk or head, e.g. cohesive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an anti-adhesion healing-promoting alginate dressing and a preparation method thereof, and relates to the technical field of alginate dressings. This antiseized even alginate dressing that promotes healing, including the non-woven fabrics bandage, the last interface of having seted up of non-woven fabrics bandage, the interface falls into two parts with the non-woven fabrics bandage, and the elastic band has been made up to the kneck, has made up respectively on the interior lateral wall of non-woven fabrics bandage and has pasted hook face and magic tape hair face, has seted up the slot hole on the inner wall of non-woven fabrics bandage, and the inslot is pasted and is fixed with and apply ointment or plaster, applies ointment or plaster to fill and. The preparation method of the anti-adhesion healing-promoting alginate dressing comprises two steps of dressing liquid preparation and suture bonding. The anti-adhesion healing-promoting alginate dressing and the preparation method thereof can be quickly bound to the wound of a patient, can be fixed on different parts such as the arm part and the leg part of the human body, also meet the use requirements of patients with different body sizes, are convenient to clean and replace, can be repeatedly used, and reduce unnecessary waste.
Description
Technical Field
The invention relates to the field of alginate dressings, in particular to an anti-adhesion healing-promoting alginate dressing and a manufacturing method thereof.
Background
The alginate dressing mainly comprises alginate, the alginate is natural polysaccharide carbohydrate extracted from seaweed, the alginate can promote wound healing and relieve wound pain, but most of alginate dressings in the market are used, a dressing body is attached to a wound, and can be gradually adhered to the skin in the process of wound healing, for example, a patent with the publication number of CN110935056A has the effects of sterilization and inflammation diminishing, but can be adhered to the wound in use, when a user takes down the dressing, the wound can be torn, pain is caused, secondary injury of the wound can be caused, the dressing mainly adopts bandages and gauze as carriers, the dressing is prepared after being soaked in alginate mixture, but the wound area is limited, the dressing is usually wound on the wound by using the dressing, only a small part of the alginate component on the dressing is effectively utilized, serious waste is caused, the manufacturing cost and the use cost are high, is not beneficial to popularization and use.
Disclosure of Invention
Technical problem to be solved
The invention aims to provide an anti-adhesion healing-promoting alginate dressing and a manufacturing method thereof, so as to solve the problems in the background technology.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: an anti-adhesion healing-promoting alginate dressing comprises a non-woven fabric bandage, wherein an interface is arranged on the non-woven fabric bandage, the non-woven fabric bandage is divided into two parts by the interface, an elastic band is sewn at the interface, a hook-and-loop fastener surface and a hook-and-loop fastener surface are respectively sewn on the inner wall and the outer wall of the non-woven fabric bandage, a slot hole is formed in the inner wall of the non-woven fabric bandage, a patch is fixedly bonded in the slot hole and is made of any one of non-woven fabric or gauze, a patch liquid is filled in the patch, a waistband type structural design is adopted, the patch can be quickly bound at a wound of a patient, the elastic band 2 of an elastic structure enables the dressing to be fixed on different parts such as an arm part and a leg part of the human body, the use requirements of patients with different body shapes are met, the use scene and the use range, avoid cross infection, on the other hand nurses to the wound position, compares the dressing that partly with alginate material direct immersion dressing in, has reduced the unnecessary waste of active ingredient, reduces manufacturing and use cost, and the dressing liquid includes the raw materials of following parts: 30-36 parts of alginate, 14-22 parts of hyaluronic acid, 12-16 parts of glycerol, 8-10 parts of ethanol, 6-8 parts of frankincense arabic, 4.8-7.2 parts of collagen, 4-6 parts of thickening agent and 2.4-3.6 parts of carboxymethyl chitosan, and the adhesive can keep moist when being attached to a wound, so that the adhesive is not easy to adhere to the wound in the wound healing process, the possibility of tearing the wound when the dressing is taken off is avoided, and the pain of a user is relieved.
Preferably, the alginate is any one of alginic acid, calcium alginate and potassium alginate.
Preferably, the ethanol concentration is 78-88 wt%.
Preferably, the thickener is any one of sodium alginate, guar gum or xanthan gum.
Preferably, the size of the application is 5 x 5-8 cm.
A preparation method of the anti-adhesion healing-promoting alginate dressing comprises the following steps:
firstly, preparation of a dressing solution:
1) putting hyaluronic acid, glycerol and ethanol in corresponding parts into an oil phase pot, heating and stirring, controlling the heating temperature to rise to 75-95 ℃ and keeping constant temperature, controlling the stirring speed to be 200 revolutions per minute, after the hyaluronic acid is completely melted, controlling the heating temperature to fall to 48-56 ℃ and keeping constant temperature, then putting collagen and carboxymethyl chitosan in corresponding parts into the oil phase pot, continuously heating and stirring for 20 minutes to obtain an oil phase, pouring the oil phase out of the oil phase pot, and cooling the oil phase to the normal temperature for later use;
2) putting corresponding parts of alginate, gum arabic and water into a distiller for distillation and condensation to obtain a solvent;
3) pouring the oil phase and the solvent into an emulsion pot for preheating, after preheating to 30-40 ℃, pouring the mixture out of the emulsion pot, putting the mixture into a homogenizer together with a corresponding part of a thickening agent for two-stage homogenization, and obtaining a dressing solution after homogenization;
secondly, sewing and bonding: taking a group of non-woven fabric bandage and cutting the non-woven fabric bandage into two parts, then taking a group of elastic bands to sew the non-woven fabric bandage at the incision, reconnecting the two parts of the non-woven fabric bandage by the elastic bands, respectively taking a group of hook and loop fastening surfaces and hook and loop fastening surfaces to be respectively sewn on the front surface and the back surface of the non-woven fabric bandage, digging a groove on the front surface of the non-woven fabric bandage, then coating glue in the groove, taking a group of application plaster to be adhered in the groove, and after the groove is firmly adhered, taking a proper amount of application liquid to be coated on the application plaster to obtain the anti-adhesion healing promoting alginate.
Preferably, the part of water put into the distiller in the step one is 2-3 times of the sum of the parts of the two raw materials of the alginate and the frankincense arable.
Preferably, when the second-stage homogenizing is performed by the homogenizer in the first-stage homogenizing, the first-stage homogenizing rotation speed is 1200-1600 revolutions per minute, the homogenizing pressure is 2.4-3.6MPa, the second-stage homogenizing rotation speed is inconvenient to maintain, and the homogenizing pressure is reduced to 0.44-0.58 MPa.
Preferably, the glue used in the second step is any one of pressure-sensitive glue.
(III) advantageous effects
Compared with the prior art, the invention provides the anti-adhesion healing-promoting alginate dressing and the preparation method thereof, and the anti-adhesion healing-promoting alginate dressing has the following beneficial effects:
1. the anti-adhesion healing-promoting alginate dressing structurally adopts a waistband type structural design, can be quickly bound to a wound of a patient, can be fixed on different parts such as an arm part and a leg part of the patient, also meets the use requirements of the patients with different body shapes, widens the use scene and range of the dressing, is convenient to clean and replace on one hand, can be repeatedly used and avoids cross infection on the other hand, and nurses the wound position on the other hand, compared with the dressing which partially and directly immerses alginate materials into the dressing, reduces the unnecessary waste of effective components, reduces the manufacturing and use cost, indirectly promotes the sales volume of the dressing, is favorable for popularization and use, has novel structure and convenient use, and can accelerate the regeneration speed of human tissues after contacting the wound by using alginate and collagen as main materials in the dressing liquid added in the dressing, promote wound healing, ethanol and carboxymethyl chitosan have still been added simultaneously and have disinfected the anti-inflammatory treatment to the wound, reduce the wound that bacterial growing arouses and appear infecting the possibility of the inflammation condition, arab frankincense can play the effect of relieving pain, alleviate the painful sense of patient's wound, promote and use experience, glycerine has still been added in this dressing, the activity of applying the liquid has been promoted, keep moist when this dressing and wound laminating, and then difficult in-process rather than the adhesion at wound healing, the possibility of tearing the wound condition appears when having avoided taking off the dressing, alleviate user's pain, excellent in use effect, do benefit to popularization and use.
2. The method for manufacturing the anti-adhesion healing-promoting alginate dressing has the advantages that the dressing liquid and the dressing body are separately processed, the production and processing efficiency is high, the processing and processing means under different conditions are adopted for the dressing liquid according to different characteristics of various raw materials in the dressing liquid, effective ingredients in the dressing liquid can be fully extracted and retained, the efficacy of the dressing is guaranteed, the dressing body is simple and easy to obtain in material, the processing and production cost is low, the operation is simple, the steps are simplified, and compared with a manufacturing method with a complex part of structure and long steps, the method is more suitable for being put into production in a large scale.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
In the figure: 1 non-woven fabrics bandage, 2 elastic bands, 3 hook and loop fasteners, 4 hook and loop fasteners, 5 are applied.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
referring to fig. 1, the present invention provides a technical solution:
the utility model provides an antiseized even alginate dressing that promotes healing, including non-woven fabrics bandage 1, the interface has been seted up on the non-woven fabrics bandage 1, the interface falls into two parts with non-woven fabrics bandage 1, elastic band 2 has been made up to the kneck, make up respectively on the interior lateral wall of non-woven fabrics bandage 1 and paste hook face 3 and magic tape hair side 4, the slot hole has been seted up on the inner wall of non-woven fabrics bandage 1, paste in the slot hole and be fixed with application 5, application 5 is arbitrary one of non-woven fabrics or gauze, the size of application 5 is 5cm, it has the dressing solution to apply ointment or plaster 5 last packing, the dressing solution includes the raw materials of following parts: 30 parts of alginate, 14 parts of hyaluronic acid, 12 parts of glycerol, 8 parts of ethanol, 6 parts of gum arabic, 4.8 parts of collagen, 4 parts of a thickening agent and 2.4 parts of carboxymethyl chitosan, wherein the alginate is alginic acid, the concentration of the ethanol is 78 wt%, and the thickening agent is sodium alginate.
A preparation method of the anti-adhesion healing-promoting alginate dressing comprises the following steps:
firstly, preparation of a dressing solution: 1) putting hyaluronic acid, glycerol and ethanol in corresponding parts into an oil phase pot, heating and stirring, controlling the heating temperature to rise to 75 ℃ and keeping constant temperature, wherein the stirring speed is 200 revolutions per minute, controlling the heating temperature to fall to 48 ℃ and keeping constant temperature after the hyaluronic acid is completely melted, then putting collagen and carboxymethyl chitosan in corresponding parts into the oil phase pot, continuously heating and stirring for 20 minutes to obtain an oil phase, pouring the oil phase out of the oil phase pot, and cooling the oil phase to the normal temperature for later use; 2) putting corresponding parts of alginate, Arab mastic and water into a distiller for distillation and condensation to obtain a solvent, wherein the part of the water is 2 times of the sum of the parts of the alginate and the Arab mastic; 3) pouring the oil phase and the solvent into an emulsion pot for preheating, after preheating to 30 ℃, pouring the mixture out of the emulsion pot, putting the mixture into a homogenizer together with a corresponding part of a thickening agent for two-stage homogenization, wherein the first-stage homogenization rotation speed is 1200 revolutions per minute, the homogenization pressure is 2.4, the second-stage homogenization rotation speed is inconvenient to keep, the homogenization pressure is reduced to 0.44MPa, and the dressing solution is obtained after homogenization;
secondly, sewing and bonding: a group of non-woven fabric bandage 1 is taken and cut into two parts, a group of elastic bands 2 is taken and sewn at the incision of the non-woven fabric bandage 1, the two parts of the non-woven fabric bandage 1 are reconnected by the elastic bands 2, a group of hook-and-loop fasteners 3 and a group of hook-and-loop fasteners 4 are taken and sewn at the front and the back of the non-woven fabric bandage 1 respectively, a groove is dug in the front of the non-woven fabric bandage 1, glue is coated in the groove and is any one of pressure-sensitive glue, a group of application 5 is taken and adhered in the groove, after the groove is firmly adhered, a proper amount of application liquid is taken and coated on the application 5, and the anti-adhesion healing promoting alginate dressing is obtained.
Example two:
referring to fig. 1, the present invention provides a technical solution:
the utility model provides an antiseized even alginate dressing that promotes healing, including non-woven fabrics bandage 1, the interface has been seted up on the non-woven fabrics bandage 1, the interface falls into two parts with non-woven fabrics bandage 1, elastic band 2 has been made up to the interface, make up respectively on the interior outer wall of non-woven fabrics bandage 1 and paste hook face 3 and magic tape hair side 4, the slot hole has been seted up on the inner wall of non-woven fabrics bandage 1, paste in the slot hole and be fixed with application 5, application 5 is arbitrary one of non-woven fabrics or gauze, the size of applying ointment or plaster 5 is 5 x 6.5cm, it has the solution of applying ointment or plaster to fill on 5 applying ointment or plaster, the solution of: 33 parts of alginate, 18 parts of hyaluronic acid, 14 parts of glycerol, 9 parts of ethanol, 7 parts of gum arabic, 6 parts of collagen, 5 parts of a thickening agent and 3 parts of carboxymethyl chitosan, wherein the alginate is calcium alginate, the ethanol concentration is 83 wt%, and the thickening agent is guar gum.
A preparation method of the anti-adhesion healing-promoting alginate dressing comprises the following steps:
firstly, preparation of a dressing solution: 1) putting hyaluronic acid, glycerol and ethanol in corresponding parts into an oil phase pot, heating and stirring, controlling the heating temperature to rise to 85 ℃ and keeping constant temperature, wherein the stirring speed is 200 revolutions per minute, controlling the heating temperature to fall to 52 ℃ and keeping constant temperature after the hyaluronic acid is completely melted, then putting collagen and carboxymethyl chitosan in corresponding parts into the oil phase pot, continuously heating and stirring for 20 minutes to obtain an oil phase, pouring the oil phase out of the oil phase pot, and cooling the oil phase to the normal temperature for later use; 2) putting corresponding parts of alginate, Arab mastic and water into a distiller for distillation and condensation to obtain a solvent, wherein the part of the water is 2.5 times of the sum of the parts of the alginate and the Arab mastic; 3) pouring the oil phase and the solvent into an emulsion pot for preheating, after preheating to 35 ℃, pouring the mixture out of the emulsion pot and putting the mixture into a homogenizer together with a corresponding part of a thickening agent for two-stage homogenization, wherein the first-stage homogenization rotation speed is 1400 revolutions per minute, the homogenization pressure is 3.0MPa, the second-stage homogenization rotation speed is inconvenient to keep, the homogenization pressure is reduced to 0.51MPa, and the dressing solution is obtained after homogenization;
secondly, sewing and bonding: a group of non-woven fabric bandage 1 is taken and cut into two parts, a group of elastic bands 2 is taken and sewn at the incision of the non-woven fabric bandage 1, the two parts of the non-woven fabric bandage 1 are reconnected by the elastic bands 2, a group of hook-and-loop fasteners 3 and a group of hook-and-loop fasteners 4 are taken and sewn at the front and the back of the non-woven fabric bandage 1 respectively, a groove is dug in the front of the non-woven fabric bandage 1, glue is coated in the groove and is any one of pressure-sensitive glue, a group of application 5 is taken and adhered in the groove, after the groove is firmly adhered, a proper amount of application liquid is taken and coated on the application 5, and the anti-adhesion healing promoting alginate dressing is obtained.
Example three:
referring to fig. 1, the present invention provides a technical solution:
the utility model provides an antiseized even alginate dressing that promotes healing, including non-woven fabrics bandage 1, the interface has been seted up on the non-woven fabrics bandage 1, the interface falls into two parts with non-woven fabrics bandage 1, elastic band 2 has been made up to the kneck, make up respectively on the interior lateral wall of non-woven fabrics bandage 1 and paste hook face 3 and magic tape hair side 4, the slot hole has been seted up on the inner wall of non-woven fabrics bandage 1, paste in the slot hole and be fixed with application 5, application 5 is arbitrary one of non-woven fabrics or gauze, the size of application 5 is 5 x 8cm, it has the dressing solution to fill on application 5, the dressing solution includes the raw materials of following parts: 36 parts of alginate, 22 parts of hyaluronic acid, 16 parts of glycerol, 10 parts of ethanol, 8 parts of gum arabic, 7.2 parts of collagen, 6 parts of a thickening agent and 3.6 parts of carboxymethyl chitosan, wherein the alginate is potassium alginate, the concentration of the ethanol is 88 wt%, and the thickening agent is xanthan gum.
A preparation method of the anti-adhesion healing-promoting alginate dressing comprises the following steps:
firstly, preparation of a dressing solution: 1) putting hyaluronic acid, glycerol and ethanol in corresponding parts into an oil phase pot, heating and stirring, controlling the heating temperature to rise to 95 ℃ and keeping constant temperature, controlling the stirring speed to be 200 revolutions per minute, controlling the heating temperature to fall to 56 ℃ and keeping constant temperature after the hyaluronic acid is completely melted, then putting collagen and carboxymethyl chitosan in corresponding parts into the oil phase pot, continuously heating and stirring for 20 minutes to obtain an oil phase, pouring the oil phase out of the oil phase pot, and cooling the oil phase to the normal temperature for later use; 2) putting corresponding parts of alginate, Arab mastic and water into a distiller for distillation and condensation to obtain a solvent, wherein the part of the water is 3 times of the sum of the parts of the alginate and the Arab mastic; 3) pouring the oil phase and the solvent into an emulsion pot for preheating, after preheating to 40 ℃, pouring the mixture out of the emulsion pot, putting the mixture into a homogenizer together with a corresponding part of a thickening agent for two-stage homogenization, wherein the first-stage homogenization rotation speed is 1600 revolutions per minute, the homogenization pressure is 3.6MPa, the second-stage homogenization rotation speed is inconvenient to keep, the homogenization pressure is reduced to 0.58MPa, and the dressing solution is obtained after homogenization;
secondly, sewing and bonding: a group of non-woven fabric bandage 1 is taken and cut into two parts, a group of elastic bands 2 is taken and sewn at the incision of the non-woven fabric bandage 1, the two parts of the non-woven fabric bandage 1 are reconnected by the elastic bands 2, a group of hook-and-loop fasteners 3 and a group of hook-and-loop fasteners 4 are taken and sewn at the front and the back of the non-woven fabric bandage 1 respectively, a groove is dug in the front of the non-woven fabric bandage 1, glue is coated in the groove and is any one of pressure-sensitive glue, a group of application 5 is taken and adhered in the groove, after the groove is firmly adhered, a proper amount of application liquid is taken and coated on the application 5, and the anti-adhesion healing promoting alginate dressing is obtained.
It can be seen from this that: most alginate dressings on the market are used, the dressing body is attached to a wound, the alginate dressings can be gradually adhered to the skin in the wound healing process, the sterilization and inflammation diminishing effects are realized in a comparison case, the alginate dressings can be adhered to the wound in use, the wound can be torn when a user takes the dressings down, the secondary injury of the wound can be caused while the pain is brought, bandages and gauze are adopted as carriers in the dressing, the dressing is prepared after the dressing is soaked in alginate mixture, the wound area is limited, the dressing can be wound on the wound normally by using the dressing, only a small part of alginate components on the dressing is effectively utilized to cause waste, the anti-adhesion healing promoting alginate dressing structurally adopts a waistband type structural design, the dressing can be quickly bound on the wound of a patient, the use requirements of patients with different body shapes are met, and the use scenes and the range of the dressing are widened, paste 5 applying ointment or plaster on non-woven fabrics bandage 1 on the one hand and be convenient for wash, change, repeatedly usable, on the other hand nurses to the wound position, compare in the part with the dressing of alginate material direct immersion in dressing, it is extravagant to have reduced active ingredient unnecessary, reduce manufacturing and use cost, glycerine has still been added, the activity of applying the liquid has been promoted, keep moist when this dressing is laminated with the wound, and then difficult in-process rather than the adhesion healing wound, the possibility that appears tearing the wound condition when having avoided taking off the dressing does benefit to popularization and use.
Claims (9)
1. An anti-adhesion healing-promoting alginate dressing, which is characterized in that: including non-woven fabrics bandage (1), the interface has been seted up on non-woven fabrics bandage (1), the interface falls into two parts with non-woven fabrics bandage (1), elastic band (2) have been made up to the kneck, magic subsides hook face (3) and magic subsides hair side (4) have been made up respectively on the interior outer wall of non-woven fabrics bandage (1), the slot hole has been seted up on the inner wall of non-woven fabrics bandage (1), it is fixed with in the slot hole applies ointment or plaster (5), apply ointment or plaster (5) are arbitrary one in non-woven fabrics or the gauze, it has the liquid of applying to fill on applying ointment or plaster (5), the liquid of applying ointment or plaster includes: 30-36 parts of alginate, 14-22 parts of hyaluronic acid, 12-16 parts of glycerol, 8-10 parts of ethanol, 6-8 parts of gum arabic, 4.8-7.2 parts of collagen, 4-6 parts of thickening agent and 2.4-3.6 parts of carboxymethyl chitosan.
2. The adhesion-preventing healing-promoting alginate dressing according to claim 1, wherein: the alginate is any one of alginic acid, calcium alginate or potassium alginate.
3. The adhesion-preventing healing-promoting alginate dressing according to claim 1, wherein: the concentration of the ethanol is 78-88 wt%.
4. The adhesion-preventing healing-promoting alginate dressing according to claim 1, wherein: the thickening agent is any one of sodium alginate, guar gum or xanthan gum.
5. The adhesion-preventing healing-promoting alginate dressing according to claim 1, wherein: the size of the application patch (5) is 5 x 5-8 cm.
6. A preparation method of the anti-adhesion healing-promoting alginate dressing is characterized in that: the method comprises the following steps:
firstly, preparation of a dressing solution: 1) putting hyaluronic acid, glycerol and ethanol in corresponding parts into an oil phase pot, heating and stirring, controlling the heating temperature to rise to 75-95 ℃ and keeping constant temperature, controlling the stirring speed to be 200 revolutions per minute, after the hyaluronic acid is completely melted, controlling the heating temperature to fall to 48-56 ℃ and keeping constant temperature, then putting collagen and carboxymethyl chitosan in corresponding parts into the oil phase pot, continuously heating and stirring for 20 minutes to obtain an oil phase, pouring the oil phase out of the oil phase pot, and cooling the oil phase to the normal temperature for later use; 2) putting corresponding parts of alginate, gum arabic and water into a distiller for distillation and condensation to obtain a solvent; 3) pouring the oil phase and the solvent into an emulsion pot for preheating, pouring the mixture out of the emulsion pot after preheating to 30-40 ℃, putting the mixture into a homogenizer together with a corresponding part of the thickening agent for two-stage homogenization, and obtaining a dressing solution after homogenization;
secondly, sewing and bonding: taking a group of non-woven fabric bandage (1) and cutting the non-woven fabric bandage into two parts, then taking a group of elastic bands (2) to sew up the incision of the non-woven fabric bandage (1), reconnecting the two parts of the non-woven fabric bandage (1) by the elastic bands (2), then respectively taking a group of hook and loop fastening surfaces (3) and hook and loop fastening surfaces (4) to be respectively sewn on the front surface and the back surface of the non-woven fabric bandage (1), digging a groove on the front surface of the non-woven fabric bandage (1), then coating glue in the groove, taking a group of application plaster (5) to be pasted in the groove, and taking a proper amount of liquid to be coated on the application plaster (5) after the groove is firmly adhered, thus obtaining the anti-adhesion healing promoting alginate dressing.
7. The method for manufacturing the adhesion-prevention healing-promoting alginate dressing according to claim 5, wherein the method comprises the following steps: in the step one, the part of water put into the distiller is 2-3 times of the sum of the parts of the two raw materials of alginate and the Arab mastic.
8. The method for manufacturing the adhesion-prevention healing-promoting alginate dressing according to claim 5, wherein the method comprises the following steps: when the two-stage homogenizing is carried out by the homogenizing machine in the first step, the first-stage homogenizing rotating speed is 1200-1600 revolutions per minute, the homogenizing pressure is 2.4-3.6MPa, the second-stage homogenizing rotating speed is inconvenient to keep, and the homogenizing pressure is reduced to 0.44-0.58 MPa.
9. The method for manufacturing the adhesion-prevention healing-promoting alginate dressing according to claim 5, wherein the method comprises the following steps: and the glue used in the second step is any one of pressure-sensitive adhesives.
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| GB1379158A (en) * | 1973-02-15 | 1975-01-02 | Wallace Cameron Co Ltd | Surgical dressings |
| CN105854064A (en) * | 2016-03-28 | 2016-08-17 | 苏州蔻美新材料有限公司 | Breathable and hemostatic alginate dressing and preparation method thereof |
| CN108126236A (en) * | 2017-12-20 | 2018-06-08 | 浙江科技学院 | A kind of medicine coating material and preparation method thereof |
| CN108578747A (en) * | 2018-05-24 | 2018-09-28 | 广州芬森医学科技有限公司 | A kind of gradient hyaluronic acid dressing and preparation method thereof |
| CN211271653U (en) * | 2019-10-24 | 2020-08-18 | 广东泰宝医疗科技股份有限公司 | Bandage type alginate dressing |
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2021
- 2021-03-12 CN CN202110272031.2A patent/CN113041023A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1379158A (en) * | 1973-02-15 | 1975-01-02 | Wallace Cameron Co Ltd | Surgical dressings |
| CN105854064A (en) * | 2016-03-28 | 2016-08-17 | 苏州蔻美新材料有限公司 | Breathable and hemostatic alginate dressing and preparation method thereof |
| CN108126236A (en) * | 2017-12-20 | 2018-06-08 | 浙江科技学院 | A kind of medicine coating material and preparation method thereof |
| CN108578747A (en) * | 2018-05-24 | 2018-09-28 | 广州芬森医学科技有限公司 | A kind of gradient hyaluronic acid dressing and preparation method thereof |
| CN211271653U (en) * | 2019-10-24 | 2020-08-18 | 广东泰宝医疗科技股份有限公司 | Bandage type alginate dressing |
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