CN113028740A - Low-temperature drying device and method for pharmaceutic adjuvant - Google Patents
Low-temperature drying device and method for pharmaceutic adjuvant Download PDFInfo
- Publication number
- CN113028740A CN113028740A CN202110471958.9A CN202110471958A CN113028740A CN 113028740 A CN113028740 A CN 113028740A CN 202110471958 A CN202110471958 A CN 202110471958A CN 113028740 A CN113028740 A CN 113028740A
- Authority
- CN
- China
- Prior art keywords
- drying
- mixer
- dryer
- granulator
- screening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B1/00—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids
- F26B1/005—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids by means of disintegrating, e.g. crushing, shredding, milling the materials to be dried
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/12—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating drums
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B1/00—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B20/00—Combinations of machines or apparatus covered by two or more of groups F26B9/00 - F26B19/00
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/001—Handling, e.g. loading or unloading arrangements
- F26B25/002—Handling, e.g. loading or unloading arrangements for bulk goods
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
- F26B3/08—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B2200/00—Drying processes and machines for solid materials characterised by the specific requirements of the drying good
- F26B2200/08—Granular materials
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a low-temperature drying device and method for pharmaceutic adjuvants, which comprises a mixer, a crushing conveyor, a granulator, a dryer, a screening granulator and a secondary dryer, wherein the mixer, the crushing conveyor, the granulator, the dryer, the screening granulator and the secondary dryer are sequentially connected; a jacket is arranged outside the mixer; the mixer is also connected with a vacuum system; and an unqualified particle discharge port is formed in the screening granulator and is connected with the mixer. The invention simplifies the operation difficulty of the prior art, reduces the drying temperature, keeps the dehydration process of the materials to be carried out under the safe condition, and can still carry out good drying under the condition of changing the properties of the auxiliary materials compounded in the sodium dodecyl sulfate.
Description
Technical Field
The invention relates to a low-temperature drying device and method for pharmaceutic adjuvants, which are particularly suitable for low-temperature drying of other materials compounded in sodium dodecyl sulfate.
Background
At present, pharmaceutical excipients such as sodium dodecyl sulfate and the like are mainly dried by methods such as hot air spray drying, wiped film drying, vacuum tube drying and the like. The drying process has high temperature, large equipment investment and complex operation. The hot air spray drying uses the low-concentration material containing 30 percent of solid for spraying, the emptying temperature of hot air and tail gas is higher, and the energy consumption is high. The high-concentration material containing 70% of solid is used for wiped film drying and vacuum tube drying and is indirectly heated and dried by steam, the drying temperature is generally higher than 100 ℃, the material is easy to stick on equipment, the heat-sensitive material is decomposed, metal ions are generated by equipment corrosion, and the problems of precipitation, turbidity and the like exist after the dissolution, so that pH stabilizers such as phosphate, carbonate and the like need to be added, or the pH value of the material needs to be increased. The equipment operation is comparatively complicated, and the state of material is great to drying effect influence.
In addition, other materials are added into the pharmaceutical excipients such as sodium dodecyl sulfate and the like for compounding, so that the characteristics of the materials are changed, for example, the material flowability is poor, the fluid viscosity is rapidly increased, even the fluid cannot flow, the drying difficulty is increased, and even the drying cannot be performed.
Disclosure of Invention
The invention aims to provide a low-temperature drying method of a pharmaceutic adjuvant, aiming at the defects of the existing drying mode and the drying of a compound pharmaceutic adjuvant product, simplifying the process operation difficulty, reducing the drying temperature, keeping the dehydration process of materials to be carried out under the safe condition, and simultaneously carrying out good drying under the condition of changing the properties of compounding auxiliary materials in sodium dodecyl sulfate.
The technical scheme adopted by the invention is as follows: a low-temperature drying device for pharmaceutic adjuvants comprises a mixer, a crushing conveyor, a granulator, a dryer, a screening granulator and a secondary dryer which are connected in sequence, wherein the secondary dryer is connected with the mixer; a jacket is arranged outside the mixer; the mixer is also connected with a vacuum system; and an unqualified particle discharge port is formed in the screening granulator and is connected with the mixer.
Further, the mixer comprises a paddle dryer, a palladium dryer, or a screw mixer.
Further, the granulator is a material forming device, is selected from a screw extruder, a spheronizer, a tablet press, a crusher and the like, and can be used for preparing the mixed material into long strips, tablets, spheres or irregular small particles with large surface area.
Furthermore, the dryer mainly adopts a horizontal fluidized bed dryer and a vertical fluidized bed dryer.
Further, the secondary dryer includes a belt drying, an oven drying, and a pneumatic drying.
Furthermore, the vacuum system consists of a vacuum pump and a connecting pipeline, and the boiling point of water is reduced by reducing the pressure of the system, so that non-condensable gas in the material is sucked away.
The pharmaceutic adjuvant comprises sodium dodecyl sulfate or a mixture of the sodium dodecyl sulfate and an auxiliary pharmaceutic adjuvant (preferably, the mass ratio of the sodium dodecyl sulfate is 70%); the auxiliary medicinal adjuvants comprise fatty acid methyl ester sodium sulfonate MES, fatty alcohol-polyoxyethylene ether sodium sulfate AE1S, alkyl glucoside APG, alkenyl sodium sulfonate AOS, diisooctyl succinate sodium sulfonate, sodium alkyl benzene sulfonate and sodium fatty acid.
The invention also discloses a low-temperature drying method of the pharmaceutic adjuvant, which comprises the following steps:
(1) mixing, drying and cooling: adding pharmaceutic adjuvant into the mixing machine, stirring and mixing, starting a vacuum system to pump away air, introducing hot water into the jacket for heating after absolute pressure reaches less than 10KPa, absorbing heat in the dehydration process to reduce the temperature of materials, transmitting energy in hot water to the materials through the jacket by continuous stirring and mixing, and continuously volatilizing moisture. And after the moisture of the material is qualified, stopping heating and cooling to keep the proper hardness of the material. Heating at 50-90 deg.C, controlling water content of raw materials at 8-18%, and cooling to 5-40 deg.C;
(2) molding and drying: crushing the material treated in the step (1) into loose material, granulating and forming to obtain strip-shaped, spherical or small-particle material with larger specific surface area, conveying the material to a dryer for drying treatment to obtain particles with the size of 10-120 meshes, wherein the drying temperature is 50-80 ℃.
(3) Screening and drying: and (3) screening the particles treated in the step (2) to remove unqualified particles, and drying again at the temperature of 60-90 ℃ to obtain a finished product. According to the difference of the water content of 70% sodium dodecyl sulfate and the water content of the added auxiliary agent, 30-70% of the materials are generally returned to the mixer, and 70-30% of the materials are packaged as finished products.
Drawings
FIG. 1 is a schematic diagram of the connection of the system of the present invention.
In the figure: 1. auxiliary pharmaceutical excipients; 2. sodium lauryl sulfate; 3. a mixer; 31. a vacuum system; 32. a jacket; 4. a crushing conveyor; 5. A granulator; 6. a dryer; 7. a screening granulator; 71. discharging unqualified particles; 8. and (5) a secondary dryer.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
Example 1
A device for drying pharmaceutical excipients at low temperature is shown in figure 1: the drying device comprises a mixer 3, a crushing conveyor 4, a granulator 5, a dryer 6, a screening granulator 7 and a secondary dryer 8 which are connected in sequence, wherein the secondary dryer 8 is connected with the mixer 3; a jacket 32 is arranged outside the mixer 3; the mixer 3 is also connected with a vacuum system 31; and an unqualified particle discharge port 71 is formed in the screening granulator 7 and connected with the mixer 3.
The mixer of the present invention includes a paddle dryer, a palladium dryer or a screw mixer.
The granulator is material forming equipment selected from a screw extruder, a spheronizer, a tablet press, a crusher and the like, and can be used for preparing the mixed material into long strips, sheets, spheres or irregular small particles with large surface area.
The dryer mainly adopts a horizontal fluidized bed dryer and a vertical fluidized bed dryer.
The secondary dryer comprises the forms of belt drying, oven drying, airflow drying and the like.
The vacuum system consists of a vacuum pump and a connecting pipeline, and the non-condensable gas in the material is sucked away by reducing the pressure of the system to reduce the boiling point of water.
Example 2
A low-temperature drying method of pharmaceutic adjuvant comprises the following steps:
(1) mixing, drying and cooling: adding solid materials (comprising 1000g of lauryl sodium sulfate with 3 percent of water, lauryl sodium sulfate with 30 percent of water from the step (3) and 1000g of lauryl sodium sulfate with 30 percent of water and fresh supplement) into a mixer, stirring and mixing, starting a vacuum system to pump air, introducing hot water into a jacket for heating after the absolute pressure reaches 5KPa, wherein the heating temperature is 80 ℃, the material temperature is reduced by absorbing heat in the dehydration process, the energy in the hot water is transferred into the materials through the jacket by continuously stirring and mixing, and then the water is continuously volatilized. Controlling the water content of the raw materials to be 10%, stopping heating after the water content of the materials is qualified, cooling to 20 ℃, and drying to obtain 1855g of lauryl sodium sulfate with 10% of water content.
(2) Molding, drying and screening: and (2) crushing 1855g of the material treated in the step (1) into a loose material, rolling the loose material at the temperature of 25 ℃ by using a rolling machine to obtain spherical particles with larger specific surface area and the diameter of 0.8mm, conveying the spherical particles into a vertical fluidized bed dryer for drying treatment, wherein the drying temperature is 50-80 ℃, and dehydrating to 4% to obtain 1740g of product.
(3) And (3) drying: screening the particles treated in the step (2) to remove 100g of unqualified particles, and finally obtaining 1640g of spherical materials; drying again at 60-90 deg.C, and dehydrating the 4% water-containing granules 1640g to 3% again to obtain 1614g of product. Wherein 1000g of product with 3 percent of water returns to the mixer for controlling the water content of the mixed material in the step (1) and improving the mixing efficiency and the dehydration efficiency. 614g of the product was packaged as a finished product.
Example 3
A low-temperature drying method of pharmaceutic adjuvant comprises the following steps:
(1) mixing, drying and cooling: adding solid materials (comprising 885g of lauryl sodium sulfate with 3 percent of water, lauryl sodium sulfate with 30 percent of water from the step (3) and 1000g of sodium dodecyl sulfate with 30 percent of water, fresh supplement, 100g of sodium diisooctyl succinate sulfonate and fresh supplement) into a mixer, stirring and mixing, wherein the water content after mixing is 16.5 percent, starting a vacuum system to pump air, introducing hot water into a jacket to heat after the absolute pressure reaches 5KPa, the heating temperature is 80 ℃, the material temperature is reduced by absorbing heat in the dehydration process, the energy in the hot water is transferred into the materials through the jacket by continuously stirring and mixing, and then the water is continuously volatilized. Controlling the water content of the raw materials to be 10%, stopping heating after the water content of the materials is qualified, cooling to 20 ℃, and drying to prepare 2138g of lauryl sodium sulfate with 10% of water content.
(2) Molding, drying and screening: and (2) crushing 2138g of the material treated in the step (1) into a loose material, then obtaining long-strip-shaped product particles with a large specific surface area and a diameter of 0.7mm by using a screw extruder at the temperature of 25 ℃, conveying the long-strip-shaped product particles into a belt type fluidized bed dryer for drying treatment, wherein the drying temperature is 80 ℃, and dehydrating to obtain sodium dodecyl sulfate with water content of 4% to obtain 2005g of the product.
(3) And (3) drying again: screening the particles treated in the step (2) to remove fine powder and large particles, and finally obtaining 1690g of strip-shaped material; drying again at 90 ℃ dehydrates 4% water granules 1690g again to 3% to give 1664g product. Of these 885g was returned to the mixer and 779g was packaged.
The above description is directed to specific embodiments of the present invention, but the present invention is not limited to the above description. Any equivalent modifications and alterations to this technical solution would be considered within the scope of this invention by those skilled in the art. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.
Claims (7)
1. The utility model provides a pharmaceutic adjuvant's low temperature drying device which characterized in that: the drying device comprises a mixer, a crushing conveyor, a granulator, a dryer, a screening granulator and a secondary dryer which are connected in sequence, wherein the secondary dryer is connected with the mixer; a jacket is arranged outside the mixer; the mixer is also connected with a vacuum system; and an unqualified particle discharge port is formed in the screening granulator and is connected with the mixer.
2. A device for drying pharmaceutical excipients at low temperature according to claim 1, characterized in that: the mixer comprises a paddle dryer, a palladium dryer, or a screw mixer.
3. A device for drying pharmaceutical excipients at low temperature according to claim 1, characterized in that: the granulator is selected from a screw extruder, a spheronizer, a tablet press and a crusher.
4. A device for drying pharmaceutical excipients at low temperature according to claim 1, characterized in that: the dryer is a horizontal fluidized bed or a vertical fluidized bed dryer.
5. A device for drying pharmaceutical excipients at low temperature according to claim 1, characterized in that: the secondary dryer comprises belt drying, oven drying and airflow drying.
6. A device for drying pharmaceutical excipients at low temperature according to claim 1, characterized in that: the vacuum system consists of a vacuum pump and a connecting pipeline.
7. A low-temperature drying method of pharmaceutic adjuvants is characterized by comprising the following steps:
(1) mixing, drying and cooling: adding pharmaceutical adjuvants into a mixer, stirring and mixing, starting a vacuum system to pump air, introducing hot water into a jacket arranged outside the mixer to heat after the absolute pressure reaches less than 10KPa, wherein the heating temperature is 50-90 ℃, the water content of the raw materials is controlled to be 8-18%, and after the water content of the materials is qualified, stopping heating and cooling to 5-40 ℃;
(2) molding and drying: crushing the material treated in the step (1) into loose material, granulating and forming, and conveying to a dryer for drying treatment at the drying temperature of 50-80 ℃ to obtain particles with the particle size of 10-120 meshes;
(3) screening and drying: and (3) screening the particles treated in the step (2) to remove unqualified particles, and drying again at the temperature of 60-90 ℃ to obtain a finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110471958.9A CN113028740A (en) | 2021-04-29 | 2021-04-29 | Low-temperature drying device and method for pharmaceutic adjuvant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110471958.9A CN113028740A (en) | 2021-04-29 | 2021-04-29 | Low-temperature drying device and method for pharmaceutic adjuvant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113028740A true CN113028740A (en) | 2021-06-25 |
Family
ID=76454788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110471958.9A Pending CN113028740A (en) | 2021-04-29 | 2021-04-29 | Low-temperature drying device and method for pharmaceutic adjuvant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113028740A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114543447A (en) * | 2022-03-16 | 2022-05-27 | 广州四季风食品科技有限公司 | Granulating process of cheese condiment |
Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090188999A1 (en) * | 2006-05-26 | 2009-07-30 | Northeastern University | Devices, methods and applications for extraction of molecules from polymeric gel electrophoretic media |
| CN102321505A (en) * | 2011-05-10 | 2012-01-18 | 浙江赞宇科技股份有限公司 | Liquid or paste fatty acid methyl ester-sodium sulfonate (MES) compound surfactant and preparation method thereof |
| KR20140049657A (en) * | 2012-10-18 | 2014-04-28 | 조선대학교산학협력단 | The fabrication method of carbon nanotube thin film |
| CN103820583A (en) * | 2014-03-06 | 2014-05-28 | 济南百诺医药科技开发有限公司 | Preparation method for granulose condensable sugar |
| CN103894137A (en) * | 2014-03-31 | 2014-07-02 | 上海化工研究院 | High-shear reaction kettle and application of kettle to production of suspension polymerization polyethylene |
| CN104983714A (en) * | 2015-08-06 | 2015-10-21 | 苏州二叶制药有限公司 | Celecoxib capsule and preparing method thereof |
| CN107014159A (en) * | 2017-04-21 | 2017-08-04 | 江苏丰益化工科技有限公司 | A kind of drying equipment and method for lauryl sodium sulfate |
| CN107033036A (en) * | 2017-04-21 | 2017-08-11 | 江苏丰益化工科技有限公司 | A kind of drying system and method for lauryl sodium sulfate |
| CN206793499U (en) * | 2017-03-02 | 2017-12-26 | 南通汇泽新材料有限公司 | Enclosed glass-fiber reinforced plastic grille raw material blending device |
| CN107574052A (en) * | 2017-08-29 | 2018-01-12 | 东明俱进化工有限公司 | A kind of preparation technology and its producing equipment of multi-color bar anion surfactant |
| CN207727005U (en) * | 2017-11-18 | 2018-08-14 | 淮安瀚康新材料有限公司 | A kind of process units of sulfuric acid vinyl ester |
| CN110578020A (en) * | 2019-09-24 | 2019-12-17 | 广西南宁万宇科技有限公司 | Method for preparing compressible sucrose from sucrose syrup |
| CN112274545A (en) * | 2020-11-17 | 2021-01-29 | 刘伟德 | Production process of red ginseng extract tablet |
| CN112500320A (en) * | 2020-12-16 | 2021-03-16 | 江苏优扬药业有限公司 | Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate |
| CN215983557U (en) * | 2021-04-29 | 2022-03-08 | 江苏优扬药业有限公司 | Pharmaceutic adjuvant's low temperature drying device |
-
2021
- 2021-04-29 CN CN202110471958.9A patent/CN113028740A/en active Pending
Patent Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090188999A1 (en) * | 2006-05-26 | 2009-07-30 | Northeastern University | Devices, methods and applications for extraction of molecules from polymeric gel electrophoretic media |
| CN102321505A (en) * | 2011-05-10 | 2012-01-18 | 浙江赞宇科技股份有限公司 | Liquid or paste fatty acid methyl ester-sodium sulfonate (MES) compound surfactant and preparation method thereof |
| KR20140049657A (en) * | 2012-10-18 | 2014-04-28 | 조선대학교산학협력단 | The fabrication method of carbon nanotube thin film |
| CN103820583A (en) * | 2014-03-06 | 2014-05-28 | 济南百诺医药科技开发有限公司 | Preparation method for granulose condensable sugar |
| CN103894137A (en) * | 2014-03-31 | 2014-07-02 | 上海化工研究院 | High-shear reaction kettle and application of kettle to production of suspension polymerization polyethylene |
| CN104983714A (en) * | 2015-08-06 | 2015-10-21 | 苏州二叶制药有限公司 | Celecoxib capsule and preparing method thereof |
| CN206793499U (en) * | 2017-03-02 | 2017-12-26 | 南通汇泽新材料有限公司 | Enclosed glass-fiber reinforced plastic grille raw material blending device |
| CN107014159A (en) * | 2017-04-21 | 2017-08-04 | 江苏丰益化工科技有限公司 | A kind of drying equipment and method for lauryl sodium sulfate |
| CN107033036A (en) * | 2017-04-21 | 2017-08-11 | 江苏丰益化工科技有限公司 | A kind of drying system and method for lauryl sodium sulfate |
| CN107574052A (en) * | 2017-08-29 | 2018-01-12 | 东明俱进化工有限公司 | A kind of preparation technology and its producing equipment of multi-color bar anion surfactant |
| CN207727005U (en) * | 2017-11-18 | 2018-08-14 | 淮安瀚康新材料有限公司 | A kind of process units of sulfuric acid vinyl ester |
| CN110578020A (en) * | 2019-09-24 | 2019-12-17 | 广西南宁万宇科技有限公司 | Method for preparing compressible sucrose from sucrose syrup |
| CN112274545A (en) * | 2020-11-17 | 2021-01-29 | 刘伟德 | Production process of red ginseng extract tablet |
| CN112500320A (en) * | 2020-12-16 | 2021-03-16 | 江苏优扬药业有限公司 | Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate |
| CN215983557U (en) * | 2021-04-29 | 2022-03-08 | 江苏优扬药业有限公司 | Pharmaceutic adjuvant's low temperature drying device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114543447A (en) * | 2022-03-16 | 2022-05-27 | 广州四季风食品科技有限公司 | Granulating process of cheese condiment |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN215983557U (en) | Pharmaceutic adjuvant's low temperature drying device | |
| JPH07100653B2 (en) | Manufacturing method and equipment for effervescent granules and tablets | |
| CN101744790B (en) | Method for preparing stable-type vitamin A microcapsules continuously | |
| WO2017084160A1 (en) | Solid formulation preparation apparatus and method | |
| CN113028740A (en) | Low-temperature drying device and method for pharmaceutic adjuvant | |
| CN107413489B (en) | A method of ultrafine slag powder is prepared using supercritical carbon dioxide | |
| CN103408780B (en) | A kind of preparation method of high-performance high absorbent resin | |
| CN112500320A (en) | Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate | |
| CN103820253B (en) | Technique and the device of powdery MES particle is prepared in a kind of serialization | |
| CN105503684A (en) | Method for extracting haematoccus pluvialis astaxanthin through CO2 in supercritical mode | |
| CN113548653B (en) | Production process of pharmaceutic adjuvant anhydrous calcium hydrophosphate with direct-pressure function | |
| CN109200099A (en) | The preparation method of Chinese medicine composition | |
| CN103773618B (en) | Process and device for continuously preparing powdery washing powder particles | |
| CN105413210A (en) | Drying device used for powdery surfactant and drying method | |
| CN107149056A (en) | A kind of production method of the expanded heavy property aquatic feeds of aniseed | |
| CN106800616A (en) | A kind of preparation method of high bulk density PVPP | |
| CN204470272U (en) | For changing food waste heating hydrolysis equipment | |
| CN201427934Y (en) | Complete equipment for continuous production of organic sludge granular fertilizer | |
| CN217025352U (en) | Device for continuously producing sodium trimetaphosphate by two-step method | |
| CN103450388B (en) | A kind of preparation method absorbing fast super absorbent resin | |
| CN103461989B (en) | Safflower bee pollen tablet and preparation method thereof | |
| CN113942989A (en) | Device and method for continuously producing sodium trimetaphosphate by two-step method | |
| CN102731802A (en) | Manufacturing process of resin product with less soluble substance and high water absorbability | |
| CN106266129A (en) | A kind of blue a kind of reed mentioned in ancient books granule preparing process | |
| CN111449062B (en) | Production and preparation process of pesticide effervescent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |