CN1130216C

CN1130216C - Medicine for preventing and treating radiation damage of central nervous system

Info

Publication number: CN1130216C
Application number: CN01109001A
Authority: CN
Inventors: 沈瑜
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-02-27
Filing date: 2001-02-27
Publication date: 2003-12-10
Anticipated expiration: 2021-02-27
Also published as: CN1310020A

Abstract

The present invention discloses a medicine for preventing and treating radiation damage to the central nervous system, which is prepared from the following raw medicinal materials of milkvetch root, morinda, white poria, ophiopogon root, dendrobe, desertliving cistanche, cornel, tangkuei tail, red peony root, hemlock parsley, dried earthworm, safflower, peach seed, thinleaf milkwort root, Chinese magnolivine fruit, quilled cinnamon and calamus. The medicine of the present invention has good effects of preventing and treating radiation damage to the central nervous system in radiotherapy.

Description

A kind of medicine of preventing and treating central nervous system's radiation injury

The present invention relates to a kind of Chinese medicine, particularly relate to a kind of Chinese medicine of the central nervous system's of control radiation injury.

In the radiotherapy of some malignant tumor (as nasopharyngeal carcinoma, cerebroma and some pulmonary carcinoma, lymphoid tumor and the esophageal carcinoma etc.), for a long time, because the needs of treatment make spinal cord or brain be subjected in various degree irradiation inevitably.In recent years, radiocurable curative effect is significantly improved, and patient's life span also has very big prolongation (from the several years to the many decades), central nervous system's radiation injury, to the long term survival patient have in various degree quality of life, many-sided influence.Especially in recent years lonizing radiation are increasing to the application of central nerve tumor therapeutant means, and curative effect also improves a lot; Thereupon, the lonizing radiation that can not avoid fully also before come into one's own to the damage of nervus centralis.Thereby also become the clinical radiotherapy doctor urgent wish one of problem of solving.This also be one at present worldwide, during with the radiation cure tumor, unsolved problem.

The performance of clinical radioactivity spinal cord injury begins for limbs numb sense is arranged, different because of irradiated site, the general more lower limb that appear at engender the unable and dyskinesia later on, part patient urinate in addition (it is unclean to contain row) and/or difficult defecation etc. develop into then forming paraplegia at last.Clinical in the past this type of symptom is lacked effective treatment way, only can be to the ill with some medicines of suiting the medicine to the illness such as vitamin B1, B6, B12, compound vitamin B etc., even with Yan oxalic acid, 6542 injection etc., and add hormone medicine; But all can not the favourable signs of the heart state of an illness, more can't fundamentally stop the development of the state of an illness.

According to clinical needs, and in, on the basis of doctor trained in Western medicine to radioactivity central nervous system injury understanding, with reference to relevant proved recipe in ancient times, be the patient of radiation myelitis to clinical definite, be to have the patient of clinical manifestation in various degree to treat with the form of opening Chinese medicine compound.

The object of the invention is to provide a kind of Chinese medicine of the central nervous system's of control radiation injury.

The present invention seeks to be achieved through the following technical solutions: choose crude drug

Radix Astragali 40-80 Radix Morindae Officinalis 5-20 Poria 5-20 5-20 Radix Ophiopogonis

Herba Dendrobii 5-20 Herba Cistanches 5-20 Fructus Corni 5-20 Radix Angelicae Sinensis 5-20

The dried Pheretima 5-10 of Radix Paeoniae Rubra 10-15 Rhizoma Chuanxiong 5-10 Flos Carthami 5-10

Semen Persicae 5-10 Radix Polygalae 5-10 Fructus Schisandrae Chinensis 5-10 Cortex Cinnamomi 1-5

Rhizoma Acori Graminei 1-5

The above-mentioned raw materials medicine is made clinical acceptable forms, as tablet, electuary, granule, capsule, injection etc.

Medicine of the present invention confirms that through pharmacodynamic experiment control central nervous system radiation injury is had good effect.

Know from experience for many years based on clinical drug radiotherapy of the present invention is myelitic, the nasopharyngeal carcinoma of considering China's pilosity is based on radiotherapy, range of exposures relates to the temporal lobe and the neck marrow of brain, and the clinical effectiveness of nasopharyngeal carcinoma radiotherapy is good, and patient's time-to-live is long, as complication, radiation myelitis not only can appear but also in the time-to-live elder, also serious hypomnesis can take place, learning capacity weakens, even the temporal lobe necrosis occurs.For this reason, be that corresponding experiment has been carried out on the basis at nearly 3 years with the relatively-stationary prescription of clinical practice gained, the result who obtains is as follows.The experimentation of mice Brain Radiation Injury:

1, to the influence of memory and learning capacity:

Shown by the mensuration in 2,4,6,8 weeks after cervical region, whole brain irradiation or half brain add the cervical region once irradiating with maze method and diving tower method mice, memory ability of mice and learning capacity two Zhou Shijun behind exposure have decline to a certain degree, but passing in time, the medication group is recovered early and thoroughly can reach at last and the same memory level of undosed mice tool; The memory ability of simple exposure mice then fails to recover always.

Behind further mice whole brain irradiation, two rush hours (shining back second day and the 8th week) of reflection learning and memory of little mouse power radiation injury in the diving tower experiment, irradiation adds the obviously single simple irradiation group of Chinese drug-treated group mouse wrong number for few, and it simple irradiation group occurs also significantly being longer than wrong incubation period.Illustrate that medicine of the present invention can obviously improve the degree of injury because of the learning memory due to the whole brain irradiation in the peak period of radiation injury.

2, to the influence of the subependymal region cell that is subjected to the whole brain irradiation mice:

(1) the irradiation back is 2,6,24,48 hours, and the group of taking medicine mouse brain subependymal region cytometer number average is higher than simple irradiation group.See Fig. 1

(2) 6,24,48 hours the group mice ependyma inferior segment apoptotic index of taking medicine in irradiation back is starkly lower than simple irradiation group (P＜0.01).See Fig. 2

(3) rising of irradiation back mouse brain subependymal region cell C-FOS SABC positive rate all was starkly lower than simple irradiation group (P＜0.01) in 2,6 hours after irradiation, at 6 hours substantially near normal value.The C-FOS of each group expresses all similar simple matched group after 24 hours, sees Fig. 3.

(4) the SABC positive rate of irradiation back mouse brain subependymal region cell C-JUN and p53 all occurred raising in irradiation in back 2 hours, and returned to normal level in 120 hours.C-JUN peaked in 6 hours, and p53 then peaked in 24 hours.The C-JUN that Chinese medicine adds the irradiation group is seeing Fig. 4 according to afterwards all being starkly lower than simple irradiation group (P＜0.01) in 2,6,24 hours, and the positive rate of p53 then all was starkly lower than simple irradiation group (P＜0.01) at 2,6,24,48 hours, see Fig. 5.

Irradiation adds each time point mouse brain subependymal region cell number of Chinese drug-treated group obviously more than simple irradiation group, illustrates that medicine of the present invention can protect ventricles of the brain periosteum inferior segment cell to avoid or alleviate radiation injury; Irradiation back Chinese drug-treated group mouse brain subependymal region apoptotic index is starkly lower than simple irradiation group, illustrates that Chinese medicine medicine of the present invention has the apoptotic effect of the ventricles of the brain periosteum inferior segment of inhibition.Experiment in the past confirmed once that the dynamic change that C-JUN expresses was approaching with the variation tendency of apoptotic index, and p53 expression dynamic change is then consistent with the variation of apoptotic index and cell number, points out this importance that both act in the subependymal region apoptosis process.

3, the overall condition of mice:

Be subjected to two groups of whole brain irradiation certain mortality rate is all arranged after irradiation.Irradiation adds the dead absolute number of Chinese drug-treated group a little less than simple irradiation group, but two group difference not statistically significants.

The change of mice body weight, irradiation back is within 8 weeks, and two groups body weight is similar, and between the two gap increases gradually after 12 weeks, and the group that takes traditional Chinese medicine during 48 weeks body weight is seen Fig. 6 apparently higher than simple irradiation group (0.01＜P＜0.05).

Reflect that medicine of the present invention has the radioprotective effect to mice integral body.

Above-mentioned experimental result prompting medicine of the present invention not only moves radiocurable complication---nervus centralis radiation injurys such as focus and nasopharyngeal carcinoma to cerebroma, vertigo, therapeutical effect is arranged, and as just beginning to use simultaneously, also have preventive effect during radiotherapy.

Description of drawings:

Fig. 1 is three groups of mice subependymal region cell countings;

Fig. 2 is Chinese drug-treated group and simple irradiation group Kunming mouse subependymal region apoptotic index;

Fig. 3 is Chinese drug-treated group and simple irradiation group Kunming mouse subependymal region cell C-FOS positive rate;

Fig. 4 is Chinese drug-treated group and simple irradiation group Kunming mouse subependymal region cell C-JUN positive rate;

Fig. 5 is Chinese drug-treated group and simple irradiation group Kunming mouse subependymal region cell P53 positive rate;

Fig. 6 has significance (0.01＜P＜0.05) with single according to group difference for irradiation back 48 all Chinese drug-treated group and group.

Embodiment:

Choose crude drug:

Radix Astragali 65g halberd meat 10g Poria 10g 10g Radix Ophiopogonis

Herba Dendrobii 10g Herba Cistanches 10g Fructus Corni 10g Radix Angelicae Sinensis 12.5g

The dried Pheretima 6g of Radix Paeoniae Rubra 12.5g Rhizoma Chuanxiong 6g Flos Carthami 6g

Semen Persicae 6g Radix Polygalae 6g Fructus Schisandrae Chinensis 6g Cortex Cinnamomi 3g

Rhizoma Acori Graminei 3g

Above-mentioned raw materials is pulverized, crossed 100 mesh sieves, and technology is made powder routinely.

Claims

1, a kind of medicine of preventing and treating central nervous system's radiation injury is characterized in that this medicine is to be made by following crude drug by weight:

Rhizoma Acori Graminei 1-5

2, medicine as claimed in claim 1 is characterized in that this medicine is to be made by following crude drug by weight:

10 Radix Ophiopogonis 10 of the Radix Astragali 65 halberd meat 10 Porias

Herba Dendrobii 10 Herba Cistanches 10 Fructus Corni 10 Radix Angelicae Sinensis 12.5

Radix Paeoniae Rubra 12.5 Rhizoma Chuanxiongs 6 dried Pheretima 6 Flos Carthamis 6

Semen Persicae 6 Radix Polygalaes 6 Fructus Schisandrae Chinensis 6 Cortex Cinnamomi 3

Rhizoma Acori Graminei 3