CN113017175A - Mask for preventing novel coronavirus pneumonia - Google Patents
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- CN113017175A CN113017175A CN202110369555.3A CN202110369555A CN113017175A CN 113017175 A CN113017175 A CN 113017175A CN 202110369555 A CN202110369555 A CN 202110369555A CN 113017175 A CN113017175 A CN 113017175A
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Abstract
The invention discloses a mask for preventing novel coronavirus pneumonia, which comprises a main body, a supporting layer and a composite layer, wherein the supporting layer is arranged on one side of the main body, the composite layer is arranged on one side of the supporting layer far away from the main body, a pocket is formed in one side of the composite layer far away from the supporting layer, a filter element is movably arranged in the pocket and comprises a waterproof layer, non-woven fabrics and a pressing sheet, the waterproof layer is arranged on one side of the non-woven fabrics, and the pressing sheet is filled between the waterproof layer and the non-woven fabrics. The mask disclosed by the invention has a certain inhibition effect on viruses; the medicine has the effect of adjuvant therapy for patients with mild symptoms; for ordinary people, the health-care tea can improve immunity and prevent the people from inhaling air containing viruses.
Description
Technical Field
The invention relates to the technical field of masks, in particular to a mask for preventing novel coronavirus pneumonia.
Background
The mask is a sanitary article, generally refers to a device which is worn at the mouth and nose part and used for filtering air entering the mouth and nose so as to prevent harmful gas, smell and spray from entering and exiting the mouth and nose of a wearer, and is made of gauze or paper and the like. The mask has a certain filtering function on air entering the lung, and has a very good effect when being worn in respiratory infectious diseases and working in environments polluted by dust and the like.
Pneumonia, an inflammation of the terminal airways, alveoli and lung interstitium; pneumonia can be caused by various bacteria and viruses, but most of the bacteria and viruses are streptococcus pneumoniae, and the type III of the streptococcus pneumoniae is most pathogenic. A few are pneumococcus, staphylococcus aureus, hemolytic streptococcus, haemophilus influenzae, etc. Pneumonia is not caused if the bacterium-eliminating self-cleaning function of respiratory tract and the resistance of organism are normal. When the respiratory defense function is weakened due to cold, over-fatigue, intoxication, cold, diabetes, hypoimmunity, etc., bacteria or viruses invade into alveoli and the permeability of capillaries in alveolar walls is enhanced by allergic reaction, serous fluid and cellulose exude, bacteria in protein-rich exudate rapidly proliferate and spread to adjacent lung tissues through the alveolar foramen or respiratory bronchioles, and pneumonia is caused by spreading to one lung segment or the whole lung lobe.
Most of current medical gauze mask are the disposable gauze mask of non-woven fabrics, certain dustproof and strain the fungus function has, but can not kill the germ, but the germ of hospital is more, the gauze mask can show better dustproof and strain the fungus performance when just beginning to use, but along with the extension of wearing time, the germ on gauze mask surface is amassed more and more, it is also more and more weak to strain the fungus performance, the gauze mask has also lost the guard action, consequently under the severe form of present new crown pneumonia epidemic prevention, it is all right to develop an antiviral effect, the gauze mask that can use for a long time, become the hot subject that an urgent need of solving in this field.
Chinese patent publication No. CN103948188B discloses a traditional Chinese medicine protective mask filter element for purifying PM2.5, which comprises a three-layer structure, from outside to inside, a spun-bonded nonwoven fabric layer, an activated carbon fiber nonwoven fabric layer and an inner lining cotton woven layer are sequentially arranged, the layers are bonded by hot melt adhesive, and the periphery of the outer side of the inner lining cotton woven layer is provided with non-setting adhesive. The preparation method of the activated carbon fiber type non-woven fabric layer is that the activated carbon fiber type non-woven fabric is sprayed with the mixed extract of traditional Chinese medicine. The mask filter element is simple in structure, low in cost, simple to manufacture and strong in filtering and adsorbing effects, the traditional Chinese medicine nursing leaching solution is adopted to moisten the lung and treat respiratory diseases, the non-setting adhesive is applied to the connection of the mask filter element and the mask main body for the first time, the operation is simple and convenient, the efficiency is improved, and resources are saved. However, the antibacterial and antibacterial effects of the mask are not considered by the mask filter element.
Disclosure of Invention
Technical problem to be solved
The invention aims to provide a mask for preventing novel coronavirus pneumonia, and aims to solve the problems that germs cannot be killed and the mask cannot be used for a long time in the background technology.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme:
a mask for preventing novel coronavirus pneumonia comprises a main body, a supporting layer and a composite layer, wherein the supporting layer is fixedly arranged on one side of the main body, the composite layer is fixedly arranged on one side of the supporting layer away from the main body, a pocket is formed in one side of the composite layer away from the supporting layer, a filter element is movably arranged in the pocket and comprises a waterproof layer, non-woven fabrics and a pressing sheet, the waterproof layer is fixedly arranged on one side of the non-woven fabrics, and the pressing sheet is filled between the waterproof layer and the non-woven fabrics; the compressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 25-35 parts of agastache rugosus: 25-35 parts of eupatorium: 25-35 parts of cyrtomium rhizome: 25-35 parts, folium isatidis: 25-35 parts of fructus forsythiae: 25-35 parts of radix angelicae: 3-6 parts of rhizoma nardostachyos: 3-6 parts, jasmine flower: 3-6 parts, borneol: 0.2 to 0.4 portion.
By adopting the technical scheme, the filter element containing the traditional Chinese medicine pressed tablet is placed in the pocket, the bacterial virus in the air is killed by the pressed tablet, and meanwhile, the novel coronavirus patient with slight infection degree is treated, and the convenience of external treatment and the acceptability of the patient are improved.
The pressor tablet plays the effect of adjunctie therapy to the mild patient, mainly carries out through nasal mucosa dosing, nasal mucosa dosing's advantage: the nasal mucosa is simple and convenient to administer, the medicine directly enters systemic circulation after being absorbed by the nasal mucosa, the damage of enzymes in gastrointestinal tracts and the first-pass effect of liver on the medicine can be avoided, the bioavailability is favorably improved, the bioavailability of the intranasal administration of certain medicines is close to 100 percent, and the nasal mucosa-administered medicine has practical significance on the medicine with poor absorption of gastrointestinal tracts.
Preferably, the compressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 30 parts, wrinkled giant hyssop: 30 parts of eupatorium fortunei: 30 parts of cyrtomium rhizome: 30 parts, folium isatidis: 30 parts of fructus forsythiae: 30 parts of radix angelicae dahuricae: 5 parts, rhizoma nardostachyos: 5 parts, jasmine flower: 5 parts, borneol: 0.3 part.
By adopting the technical scheme, the optimal proportion of the compressed tablets is determined, and the using efficiency of nasal mucosa administration is improved.
Preferably, the filter element can be sized to cover only the mouth and nose breathing region of the user, or can cover the area outside the mouth and nose breathing concentration region of the user.
By adopting the technical scheme, the filter element is suitable for at least covering the mouth and the nose of a user to filter the air breathed by the user. For example, the filter element can be covered on the cheek of a user to expand the coverage range of the filter element, so that the filter element is suitable for users with different sizes and different face shapes, and the applicability of the filter element is improved.
Preferably, the pocket is a drawable pocket type, and the filter element is designed to be square according to the uniform distribution principle.
Preferably, the preparation method of the filter element comprises the following steps:
s1, preparing materials according to the composition of the pressed tablet raw materials;
s2, drying the raw materials until the water content is less than or equal to 3.0%, crushing, sieving with a 100-mesh sieve, and fully mixing to obtain medicinal powder;
s3, putting the mixed materials on a non-woven fabric, wrapping the other side of the non-woven fabric with a waterproof layer, sewing the periphery of the non-woven fabric and the waterproof layer to obtain the filter element, dispersing and pressing the filter element according to an even distribution principle, evenly distributing the medicinal powder in the filter element, and finally shaping the filter element into a square shape.
Through adopting foretell technical scheme, the filter core can be taken out and inserted and use in the gauze mask main part, and the medicine powder distributes more evenly in the filter core simultaneously, can not make gauze mask deformation or the actual volume grow of gauze mask under the circumstances of adding the filter core.
The pharmacological effects of the compressed tablets are further illustrated below:
the pressed tablets have the main effects of eliminating dampness, relieving exterior syndrome and clearing heat and detoxicating;
1. the three medicines of the rhizoma atractylodis, the wrinkled gianthyssop and the eupatorium in the pressed tablet prescription are matched with the aromatic medicines to remove dampness and avoid dirt, and are used for treating the symptoms of early damp-warm disease, the fever, the malaria and the like. The rhizoma atractylodis is pungent and bitter in taste and warm in nature, mainly contains volatile oil, carotene and vitamin A, has a function of promoting respiration regardless of dosage, has the effects of tonifying spleen, eliminating dampness and resisting viruses, and is used for being smeared on skin to prevent skin diseases. The agastache rugosus extract is slightly warm in nature, contains patchouli alcohol and methyl piperitol, and has an inhibitory effect on common pathogenic fungi, staphylococcus aureus and pneumococci. The eupatorium has pungent taste and mild property, contains 1.5-2% of volatile oil, and the components in the oil have direct inhibition effect on influenza virus, such as paracymenin, nerol acetate and the like.
2. The cyrtomium fortunei, the indigowoad leaf and the weeping forsythia in the pressed tablet prescription are combined to clear away heat and toxic materials, are used for treating early epidemic febrile disease and mumps and pharyngitis and have the effect of preventing various diseases caused by viruses. The rhizoma Osmundae is bitter in taste and slightly cold in nature, mainly contains aspidin, aspidin and Huangaspidin, has good inhibitory effect on influenza virus, adenovirus, Japanese encephalitis, herpes simplex and other viruses, and can be used for treating influenza; the dyers woad leaf is bitter in taste and cold in nature, is leaves and branches and leaves of perennial shrub-like herbaceous Indigofera tinctoria, European verbenaceae deciduous shrub wayside and the like, the dyer woad leaf contains tryptophan, isatin B, glucose brassin and indigo, the Indigofera tinctoria leaf contains indigoside, the indigoside is hydrolyzed to generate hydroxyindole, the indigoside is oxidized to generate indigotin, the whole Polygonum tinctoria contains the indigoside, yellow pigment and tannin, the dyers woad leaf has an inhibiting effect on hepatitis B surface antigen and an inhibiting effect on influenza virus methylene, and has the functions of resisting bacteria, resisting viruses and enhancing immunity; fructus forsythiae is bitter in taste and slightly cold in nature, contains triterpenoid saponin, and pericarp contains sterol, alkaloid, saponin, oleanolic acid, coumarins, vitamin B and a small amount of volatile oil, and has broad-spectrum antibacterial effect and has inhibitory effect on Staphylococcus aureus, Bordetella pertussis, Diplococcus pneumoniae and influenza virus.
3. The angelica dahurica, the nardostachys chinensis, the jasmine flower and the borneol in the prescription of the pressed tablet have aromatic smell, activate spleen and smooth stomach, promote qi circulation and relieve pain, eliminate fatigue and correct flavor.
(III) advantageous effects
Compared with the prior art, the mask has the following advantages:
1. preventing the wearer from inhaling too much inhalable contaminants;
2. the mask cannot be deformed or the actual volume of the mask cannot be increased under the condition of adding the filter element;
3. the novel coronavirus inhibitor has an effective prevention and control effect, and plays a certain inhibition effect on the viruses; the medicine has the effect of adjuvant therapy for patients with mild symptoms; for ordinary people, the health-care tea can improve immunity and prevent the people from inhaling air containing viruses.
Drawings
FIG. 1 is a schematic view of the overall structure of a mask for preventing novel coronavirus pneumonia according to the present invention;
FIG. 2 is a schematic view of a filter element of a mask for preventing novel coronavirus pneumonia according to the present invention;
in the figure: 1. a main body; 2. a support layer; 3. compounding layers; 4. a pocket; 5. a filter element; 51. a waterproof layer; 52. non-woven fabrics; 53. and (4) pressing the tablets.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A mask for preventing novel coronavirus pneumonia comprises a main body, a supporting layer and a composite layer, wherein the supporting layer is fixedly arranged on one side of the main body, the composite layer is fixedly arranged on one side, away from the main body, of the supporting layer, the mask main body is supported by the supporting layer to be convenient to wear, and the composite layer is arranged on the outer surface of the main body; the composite layer is provided with a pocket at one side far away from the supporting layer, a filter element is movably arranged in the pocket and comprises a waterproof layer, non-woven fabrics and a pressing sheet, the waterproof layer is fixedly arranged at one side of the non-woven fabrics, the pressing sheet is filled between the waterproof layer and the non-woven fabrics, and the waterproof layer is in contact with the composite layer; the filter element can only cover the breathing region of the mouth and the nose of a user, and can also cover the region outside the breathing concentration region of the mouth and the nose of the user; the pocket is a drawable socket bag type, and the filter element is designed to be square according to the uniform distribution principle;
the pressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 25 parts of agastache rugosa: 25 parts, eupatorium: 25 parts of cyrtomium rhizome: 25-35 parts, folium isatidis: 25 parts of fructus forsythiae: 25 parts of radix angelicae: 3 parts, rhizoma nardostachyos: 3 parts, jasmine flower: 3 parts, borneol: 0.2 part.
The preparation method of the filter element comprises the following steps:
s1, preparing materials according to the composition of the pressed tablet raw materials;
s2, drying the raw materials until the water content is less than or equal to 3.0%, crushing, sieving with a 100-mesh sieve, and fully mixing to obtain medicinal powder;
s3, putting the mixed materials on a non-woven fabric, wrapping the other side of the non-woven fabric with a waterproof layer, sewing the periphery of the non-woven fabric and the waterproof layer to obtain the filter element, dispersing and pressing the filter element according to an even distribution principle, evenly distributing the medicinal powder in the filter element, and finally shaping the filter element into a square shape.
Example 2
A mask for preventing novel coronavirus pneumonia comprises a main body, a supporting layer and a composite layer, wherein the supporting layer is fixedly arranged on one side of the main body, the composite layer is fixedly arranged on one side of the supporting layer away from the main body, a pocket is formed in one side of the composite layer away from the supporting layer, a filter element is movably arranged in the pocket and comprises a waterproof layer, non-woven fabrics and a pressing sheet, the waterproof layer is fixedly arranged on one side of the non-woven fabrics, and the pressing sheet is filled between the waterproof layer and the non-woven fabrics; the filter element can only cover the breathing region of the mouth and the nose of a user, and can also cover the region outside the breathing concentration region of the mouth and the nose of the user; the pocket is a drawable pocket type, and the filter element is designed to be square according to the uniform distribution principle.
The pressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 35 parts, wrinkled giant hyssop: 35 parts, eupatorium: 35 parts of cyrtomium rhizome: 35 parts, folium isatidis: 35 parts, forsythia suspensa: 35 parts, radix angelicae dahuricae: 6 parts, rhizoma nardostachyos: 6 parts, jasmine flower: 6 parts, borneol: 0.4 part.
The preparation method of the filter element comprises the following steps:
s1, preparing materials according to the composition of the pressed tablet raw materials;
s2, drying the raw materials until the water content is less than or equal to 3.0%, crushing, sieving with a 100-mesh sieve, and fully mixing to obtain medicinal powder;
s3, putting the mixed materials on a non-woven fabric, wrapping the other side of the non-woven fabric with a waterproof layer, sewing the periphery of the non-woven fabric and the waterproof layer to obtain the filter element, dispersing and pressing the filter element according to an even distribution principle, evenly distributing the medicinal powder in the filter element, and finally shaping the filter element into a square shape.
Example 3
A mask for preventing novel coronavirus pneumonia comprises a main body, a supporting layer and a composite layer, wherein the supporting layer is fixedly arranged on one side of the main body, the composite layer is fixedly arranged on one side of the supporting layer away from the main body, a pocket is formed in one side of the composite layer away from the supporting layer, a filter element is movably arranged in the pocket and comprises a waterproof layer, non-woven fabrics and a pressing sheet, the waterproof layer is fixedly arranged on one side of the non-woven fabrics, and the pressing sheet is filled between the waterproof layer and the non-woven fabrics; the filter element can only cover the breathing region of the mouth and the nose of a user, and can also cover the region outside the breathing concentration region of the mouth and the nose of the user; the pocket is a drawable pocket type, and the filter element is designed to be square according to the uniform distribution principle
The pressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 30 parts, wrinkled giant hyssop: 30 parts of eupatorium fortunei: 30 parts of cyrtomium rhizome: 30 parts, folium isatidis: 30 parts of fructus forsythiae: 30 parts of radix angelicae dahuricae: 5 parts, rhizoma nardostachyos: 5 parts, jasmine flower: 5 parts, borneol: 0.3 part.
The preparation method of the filter element comprises the following steps:
s1, preparing materials according to the composition of the pressed tablet raw materials;
s2, drying the raw materials until the water content is less than or equal to 3.0%, crushing, sieving with a 100-mesh sieve, and fully mixing to obtain medicinal powder;
s3, putting the mixed materials on a non-woven fabric, wrapping the other side of the non-woven fabric with a waterproof layer, sewing the periphery of the non-woven fabric and the waterproof layer to obtain the filter element, dispersing and pressing the filter element according to an even distribution principle, evenly distributing the medicinal powder in the filter element, and finally shaping the filter element into a square shape.
Remarking: in examples 1-3, the compressed tablet generally has a weight of 5-6 g. The example was specifically 5 g.
Balb/c mice are used as test animals, the male and female halves of the animals are randomly divided into 3 groups according to sex and weight, each group comprises 30 animals, and the animals are divided into a negative control group, a model group and an administration group. The animals in the model group and the administration group were infected with the mouse lung adaptive strain of the new coronary pneumonia virus by nasal drip under ether light anesthesia, and the virus amount was 0.1 half-time lethal amount (15LD 50). The medicine is administrated one week in advance before virus infection attack, whether the infection is successful is observed, 10 mice which are successfully infected are selected in each group, the medicine is continuously administrated for 5 days, the medicine is administrated by adopting atomization inhalation, the medicine is suspended in 20mL of distilled water when in use, and the medicine is filtered by a microporous membrane. The negative control group and the model group were administered with 2mL/kg of physiological saline, and the administration group was 2g/kg (crude drug, example 1). For a total of 14 days, qd. At the end of the experiment, the mice were weighed, sacrificed, lung weights were weighed, and lung indices were determined, with the results shown in table 1.
TABLE 1 pulmonary index test results Table
Note: compared to the model group,: p < 0.05, x: p is less than 0.01; lung index ═ (mouse lung weight/mouse body weight) × 100; lung index inhibition ratio (mean lung index of model group-mean lung index of nebulization group)/mean lung index of model group × 100.
Balb/c mice are used as test animals, the male and female halves of the animals are randomly divided into 3 groups according to sex and weight, each group comprises 30 animals, and the animals are divided into a negative control group, a model group and an administration group. The animals in the model group and the administration group were infected with the mouse lung adaptive strain of the new coronary pneumonia virus by nasal drip under ether light anesthesia, and the virus amount was 2 times half lethal dose (2LD 50). Observing whether the infection is successful, selecting 10 mice successfully infected in each group, continuing to administer the medicine for 5 days, qd, adopting atomization inhalation to administer the medicine, suspending the medicine in 20mL of distilled water when in use, and filtering by a microporous membrane. The negative control group and the model group were administered with 2mL/kg of physiological saline, and the administration group was 2g/kg (crude drug, example 1). Dosing was stopped after viral infection, observed for 2 weeks, and animal mortality, survival number, mortality, and mean survival time were calculated as shown in table 2.
TABLE 2 survival time of groups of mice
Note: compared to the model group,: p < 0.05, x: p is less than 0.01; extended life ═ time to foggy group mean-model group mean/model group mean x 100.
The test results show that: in Table 1, the lung index of the model group was significantly increased (P < 0.01) compared to that of the negative control group, indicating successful modeling. Compared with the model group, the lung index of the atomization group is remarkably reduced, and the difference has statistical significance (P is less than 0.05 or P is less than 0.01), which shows that the filter element pressed tablet can reduce the lung index, and the administration group achieves 28.6 percent in the aspect of lung index inhibition rate, which shows that the filter element pressed tablet plays a certain role in preventing new corolla pneumovirus; as can be seen from Table 2, the average survival time of the animals in the model group was about 12.78 days. The average survival time of animals in the atomized group is prolonged, about 14-18 days, the life rate of the animals is prolonged to more than 70%, and compared with a virus control group, the difference is statistically significant (P is less than 0.01). The research shows that the traditional Chinese medicine of the invention has good effect of preventing the new coronavirus in vivo.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A mask for preventing novel coronavirus pneumonia comprises a main body, a supporting layer and a composite layer, wherein the supporting layer is arranged on one side of the main body, the composite layer is arranged on one side of the supporting layer away from the main body, a pocket is formed in one side of the composite layer away from the supporting layer, a filter element is movably arranged in the pocket and comprises a waterproof layer, non-woven fabrics and a pressing sheet, the waterproof layer is arranged on one side of the non-woven fabrics, and the pressing sheet is filled between the waterproof layer and the non-woven fabrics; the compressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 25-35 parts of agastache rugosus: 25-35 parts of eupatorium: 25-35 parts of cyrtomium rhizome: 25-35 parts, folium isatidis: 25-35 parts of fructus forsythiae: 25-35 parts of radix angelicae: 3-6 parts of rhizoma nardostachyos: 3-6 parts, jasmine flower: 3-6 parts, borneol: 0.2 to 0.4 portion.
2. The mask according to claim 1, wherein the compressed tablet comprises the following raw materials in parts by weight:
rhizoma atractylodis: 30 parts, wrinkled giant hyssop: 30 parts of eupatorium fortunei: 30 parts of cyrtomium rhizome: 30 parts, folium isatidis: 30 parts of fructus forsythiae: 30 parts of radix angelicae dahuricae: 5 parts, rhizoma nardostachyos: 5 parts, jasmine flower: 5 parts, borneol: 0.3 part.
3. The mask according to claim 1, wherein the filter element is sized to cover only the mouth and nose breathing area of the user, or the area other than the mouth and nose breathing concentration area of the user.
4. The mask for preventing pneumonia of a novel coronavirus as set forth in claim 1, wherein said pocket is a drawable pocket type, and said filter element is designed to be square according to a uniform distribution principle.
5. The mask according to claim 1, wherein the method for preparing the filter element comprises the following steps:
s1, preparing materials according to the composition of the pressed tablet raw materials;
s2, drying the raw materials until the water content is less than or equal to 3.0%, crushing, sieving with a 100-mesh sieve, and fully mixing to obtain medicinal powder;
s3, putting the mixed materials on a non-woven fabric, wrapping the other side of the non-woven fabric with a waterproof layer, sewing the periphery of the non-woven fabric and the waterproof layer to obtain the filter element, dispersing and pressing the filter element according to an even distribution principle, evenly distributing the medicinal powder in the filter element, and finally shaping the filter element into a square shape.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113925897A (en) * | 2021-11-30 | 2022-01-14 | 北京仁紫霁生物科技有限公司 | Traditional Chinese medicine composition and bacteria eliminating card for preventing and/or treating infection of coronavirus and influenza virus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113925897A (en) * | 2021-11-30 | 2022-01-14 | 北京仁紫霁生物科技有限公司 | Traditional Chinese medicine composition and bacteria eliminating card for preventing and/or treating infection of coronavirus and influenza virus |
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Application publication date: 20210625 |