CN113009164A - Blood cell analyzer - Google Patents

Blood cell analyzer Download PDF

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Publication number
CN113009164A
CN113009164A CN201911330887.XA CN201911330887A CN113009164A CN 113009164 A CN113009164 A CN 113009164A CN 201911330887 A CN201911330887 A CN 201911330887A CN 113009164 A CN113009164 A CN 113009164A
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CN
China
Prior art keywords
module
reagent
plate
assembly
specific protein
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Pending
Application number
CN201911330887.XA
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Chinese (zh)
Inventor
严彬
汪明月
习武佳
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Shenzhen Dymind Biotechnology Co Ltd
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Shenzhen Dymind Biotechnology Co Ltd
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Priority to CN201911330887.XA priority Critical patent/CN113009164A/en
Publication of CN113009164A publication Critical patent/CN113009164A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention provides a blood cell analyzer, which comprises a frame, a shell, a plurality of cell bodies, a sampling module and a reagent needle assembly, wherein the frame is provided with a plurality of through holes; the housing covers the rack; a plurality of cell bodies are distributed in a straight line or arc shape and comprise a specific protein reaction cell and a blood conventional detection cell; the sampling module is arranged on the rack and used for carrying out reciprocating motion relative to the rack so as to sample and divide samples into the plurality of cell bodies; the reagent needle assembly is arranged on the frame and can perform swing motion so as to correspondingly swing to the specific protein reaction tank or perform triaxial motion so as to correspondingly move to the specific protein reaction tank. The blood cell analyzer provided by the invention has the advantages of compact structure and convenience in maintenance.

Description

Blood cell analyzer
Technical Field
The invention relates to the technical field of blood cell analysis, in particular to a blood cell analyzer.
Background
The blood cell analyzer is widely used in hospitals at all levels, medical inspection laboratories and regional detection centers due to its high measurement speed, high accuracy and small reagent consumption.
The existing blood cell analyzer has the problems of complex structure, inconvenient assembly and high maintenance cost.
Disclosure of Invention
The application provides a blood cell analyzer to solve among the prior art blood cell analyzer structure complicacy, inconvenient assembly, the high technical problem of maintenance cost.
In order to solve the technical problem, the application adopts a technical scheme that: provided is a blood cell analyzer including:
a frame;
a housing covering the chassis;
the system comprises a plurality of cell bodies, a plurality of cell bodies and a plurality of detection cells, wherein the cell bodies are distributed linearly or in an arc shape and comprise a specific protein reaction cell and a blood conventional detection cell;
the sampling module is arranged on the rack and used for performing complex motion relative to the rack so as to sample and sample the plurality of cell bodies;
the reagent needle assembly is arranged on the rack and can perform swing motion so as to correspondingly swing to the specific protein reaction tank or perform triaxial motion so as to correspondingly move to the specific protein reaction tank.
The beneficial effect of this application is: different from the situation of the prior art, the blood cell analyzer provided by the invention has a compact structure and is convenient to maintain.
Drawings
Fig. 1 is a front view of a blood cell analyzer according to an embodiment of the present invention.
Fig. 2 is a schematic perspective view of a frame of a blood cell analyzer according to an embodiment of the present invention.
Fig. 3 is another perspective view of the frame of the blood cell analyzer according to the embodiment of the present invention.
Fig. 4 is a schematic perspective view of a blood cell analyzer according to an embodiment of the present invention.
Fig. 5 is another perspective view schematically showing a blood cell analyzer according to an embodiment of the present invention.
FIG. 6 is a schematic perspective view of the blood cell analyzer according to the present invention with upper and lower covers removed.
Fig. 7 is a top view of the inside of the blood cell analyzer according to the embodiment of the present invention.
FIG. 8 is a top view of the inside of a blood cell analyzer according to another embodiment of the present invention.
FIG. 9 is a plan view of a blood cell analyzer according to still another embodiment of the present invention in a first state.
FIG. 10 is a plan view of a blood cell analyzer according to a second embodiment of the present invention.
Fig. 11 is a schematic perspective view of a partial assembly in a blood analyzer according to an embodiment of the present invention.
Fig. 12 is a perspective view of the refrigerated reagent module shown in fig. 11 with the cover open.
FIG. 13 is a schematic cross-sectional view of one embodiment of the chilled reagent module shown in FIG. 11.
Fig. 14 is another cross-sectional configuration schematic of an embodiment of the chilled reagent module shown in fig. 11.
Fig. 15 is a cross-sectional schematic view of another embodiment of the chilled reagent module shown in fig. 11.
Fig. 16 is a perspective view of the reagent bottle shown in fig. 12.
Fig. 17 is a perspective view of a partial assembly in a blood analyzer according to another embodiment of the present invention.
Fig. 18 is a perspective view of a partial assembly in a blood analyzer according to another embodiment of the present invention.
Fig. 19 is a schematic view of a blood analyzer in a withdrawn state of a refrigerated reagent module according to an embodiment of the present invention.
Fig. 20 is a schematic view of the blood analyzer shown in fig. 19 in a state where the refrigerated reagent module is withdrawn and the cover is opened.
Fig. 21 is a partially enlarged schematic view of fig. 20.
Fig. 22 is a schematic view of a partial plan structure of the inside of an analyzer according to an embodiment of the present invention.
Fig. 23 is a schematic perspective view of a detecting unit of the analyzer shown in fig. 22.
Fig. 24 is a schematic partial perspective view of the inside of an analyzer according to an embodiment of the present invention.
FIG. 25 is a perspective view of the heating assembly of the detection device shown in FIG. 23.
Fig. 26 is an exploded view of the heating assembly shown in fig. 25.
Fig. 27 is a perspective view of a heating block of the heating assembly shown in fig. 26.
Fig. 28 is a perspective view of a detecting member of the detecting device shown in fig. 23.
Fig. 29 is an exploded view of the detection assembly shown in fig. 28.
Detailed Description
The technical solutions of the following embodiments can be combined with each other.
Referring to fig. 1-10, an embodiment of the present invention provides a blood cell analyzer, which includes a frame, a housing, a plurality of cells, a sampling module 50, and a reagent needle assembly 14.
Wherein, the housing wraps the frame, a plurality of the cell bodies are distributed in a straight line or arc shape, and the cell bodies comprise specific protein reaction cells (54, 57) and blood conventional detection cells (61, 58, 59).
The sampling module 50 is disposed on the frame for performing horizontal reciprocating motion and vertical reciprocating motion relative to the frame to perform sampling (serum, plasma or whole blood sample) and sample the samples to a plurality of cell bodies (61, 54, 57, 58, 59).
In one embodiment, the reagent needle assembly 14 is rotatably disposed on the rack, and the reagent needle assembly 14 can perform a swinging motion to correspondingly swing to the specific protein reaction pool (54, 57) to add the reagent to the specific protein reaction pool (54, 57).
In another embodiment, shown in fig. 9 and 10, the reagent needle assembly 14 is a three-axis movement system capable of performing three-axis movement to correspondingly move to the specific protein reaction well (54, 57) to add the reagent to the specific protein reaction well (54, 57).
Specifically, as shown in fig. 7, during the swing and rotation movement of the reagent needle assembly 14, a specific protein reaction tank 54, a specific protein reaction tank 57, a cleaning tank 16, a refrigerated reagent tank 55, and a refrigerated reagent tank 56 are distributed on the swing and rotation track of the reagent needle assembly 14, wherein the number of the specific protein reaction tanks may be one, two, or three, a two-way or three-way detection is formed to increase the detection speed, the specific protein reaction tank 54 and the specific protein reaction tank 57 are used for mixing and heating the mixed liquid of the reagent and the sample, the number of the refrigerated reagent tanks (55, 56) is not limited, and one, two, or four as shown in fig. 8, etc. may be provided according to the actual detection requirement.
The blood routine detection cell comprises a DIFF cell 61, an RBC cell 58 and a WBC cell 59 which are arranged on the lower side of the sampling module 50 in sequence. The order of the DIFF pool 61, the specific protein reaction pool 54, the specific protein reaction pool 57, the RBC pool 58, and the WBC pool 59 is not limited, and for example, as shown in fig. 8, the DIFF pool 61 is located between the specific protein reaction pool 57, the RBC pool 58, and the RBC pool 58 and the WBC pool 59.
As shown in fig. 2, the frame includes a support member 3, a front plate 4, a bottom plate 5, a rear partition plate 6, a right support plate 7, a middle partition plate 8, and a left support plate 9.
Wherein, support piece 3 is installed in bottom plate 5 below and outstanding in front bezel 4, support piece 3 is used for supporting autoinjection platform 49 installation, when the assembly, will place autoinjection platform 49 on backup pad 3 from last down earlier, then on the upper portion of backup pad 3 and anterior set screw, accomplish autoinjection platform 49 and install in backup pad 3, this kind of mounting means makes things convenient for autoinjection platform 49's assembly and dismantlement, it is easy to install complex parts processing simultaneously, low in production cost.
The right side of the bottom plate 5 is provided with a heat dissipation air inlet 5-1 and an air outlet 5-2, the air inlet 5-1 is provided with a filter screen, and the air inlet 5-1 and the air outlet 5-2 are simultaneously arranged on the bottom plate 5, so that the heat dissipation effect is ensured, the internal layout of the instrument is more convenient, and the utilization rate of the internal space of the instrument is higher.
The median septum 8 is connected with front bezel 4, bottom plate 5, back baffle 6 perpendicularly, and left branch fagging 9, right branch fagging 7 are located the left and right sides of median septum 8 respectively and are connected with front bezel 4, back baffle 6 perpendicularly in order to divide into upper left assembly space, lower left assembly space, upper right assembly space, lower right assembly space with the frame. The sampling module 50 is mounted on the middle partition 8 and protrudes out of the lower right mounting space through a middle opening in the front plate 4.
The rear bulkhead 6 is provided in a concave shape for accommodating cables and/or pipes.
As shown in fig. 1, 4 and 5, the outer case includes an upper case 1, a lower case 2, a top cover 26, a left door panel 28, a right door panel 22 and a rear cover.
The upper casing 1 is mounted on the front plate 4 by a hinge, the upper casing 1 can be turned upside down around the hinge, and when the upper casing 1 is closed under the cover, the upper casing 1 is attracted and/or snapped on the front plate 4 by a magnetic member and/or a snap member. The upper shell 1 can be opened only by applying appropriate manual force, and the lower shell 2 covers the automatic sample feeding platform 49.
The left door panel 28 and/or the right door panel 22 are/is mounted on the rear partition 6 through a hinge, and are/is attracted and/or snapped on the rear partition 6 through a magnetic member and/or a snap member, and when the snap member is opened manually, the left door panel 28 and/or the right door panel 22 can be opened or closed through rotation of the hinge.
The top cover 26 is mounted on top of the frame and is secured to the rear bulkhead 6.
The back lid is installed on back baffle 6, and the end angle region is equipped with reagent interface 45 (see fig. 6) and waste liquid respectively about the back lid discharges interface 60 (see fig. 7), is used for connecting outside reagent bottle and waste liquid bucket respectively, and the instrument rear portion still is provided with net gape and serial ports in order to carry out relevant connection, and the cavity space that back baffle 6 and back lid formed is used for setting up the route of various wire rods, pipeline, makes things convenient for the inside liquid electricity of instrument to keep apart.
The upper shell 1, the door plate 28 and the right door plate 22 can be opened without using tools like screwdrivers during routine maintenance, thereby greatly facilitating the overhaul and debugging of workers and being convenient for assembly.
As shown in fig. 4, the upper right assembly space is provided with a DIFF detection module 10, an autoinjection drive circuit board 11, a pressure detection circuit board 12, a temperature control circuit board 24 and an air pump 25.
The DIFF detection module 10, the autoinjection driving circuit board 11 and the pressure detection circuit board 12 are arranged close to the front plate 4, and the DIFF detection module 10 is used for five classifications of the white blood cells.
The temperature control circuit board 24 and the air pump 25 are arranged close to the rear partition board 6, the temperature control circuit board 24 is used for controlling the temperature of a plurality of heating bodies in the blood cell analyzer, and the plurality of heating bodies can comprise heating bodies used for heating specific protein reaction tanks (54 and 57), heating bodies used for heating diluent pipelines, heating bodies used for heating specific protein detection tanks, heating bodies used for heating pipelines arranged in a winding mode and the like. The air pump 25 is used to advise the detection of the required positive or negative pressure.
As shown in fig. 4, the lower right fitting space is equipped with a reagent needle assembly 14, a refrigerated reagent module 15, a wash tank 16, a blood routine module 17, a liquid pump module 18, a pressure chamber 19, a first liquid valve module 20, a swab filter 21, and a second liquid valve module 23.
The reagent needle assembly 14 is mounted on the bottom plate 5, and is used for sucking reagents in the refrigerated reagent pools (55, 56) and distributing the reagents to the specific protein reaction pools (54, 57) and also distributing the reagents to the blood routine detection pools (61, 58, 59) according to needs, and correspondingly, the blood routine detection pools (61, 58, 59) are also distributed below the motion trail of the reagent needle assembly 14.
A chilled reagent module 15 is mounted on the floor 5 remote from the center partition 8 and adjacent the right door panel 22 to facilitate reagent replacement.
The cleaning pool 16 is arranged on the bottom plate 5 and is positioned at the side edge of the refrigerated reagent module 15 and used for cleaning the reagent needles of the reagent needle assemblies 14, and the cleaning pool 16 is used for containing cleaning liquid which has cleaning capability stronger than that of the diluent.
The blood set module 17 is mounted on the base plate 5 and is provided with the RBC and WBC tanks 58, 59 as previously described.
The liquid pump module 18 is mounted on the bottom plate 5 between the refrigerated reagent module 15 and the rear partition 6 by means of a resilient buffer mounting for providing the hydraulic power required for the test.
The first liquid valve module 20 is arranged on the rear partition plate 6 and used for controlling the on-off of the pipeline.
The pressure chamber 19 is fixed by the rear partition 6 and/or the middle partition 8 and is located on the side of the first liquid valve module 20 facing the middle partition 8 for forming a positive or negative pressure vessel.
The swab filter 21 and the second liquid valve module 23 are arranged on the rear partition 6 and are located in this order above the pressure chamber 19.
As shown in fig. 5, the upper left fitting space is equipped with a driving board 41, a spacer metal plate, a main control board 42, and a back circuit board 43, and the driving board 41, the main control board 42, and the back circuit board 43 are arranged at intervals to reduce electromagnetic interference.
A drive plate 41 is mounted on the left support plate 9 and control ports for the main electronics of the instrument are provided on the drive plate 41 for driving the various moving components, such as the sampling module 50, the reagent needle assembly 14.
The spacer sheet metal support is fixed on the left support plate 9 to provide a circuit board mounting position.
The main control board 42 is arranged on the spacing metal plate, and the main control board 42 is used for sending out related control instructions and receiving related detection signals and calculating.
The back circuit board 43 is arranged on the spacing metal plate and is vertically installed with the main control board 42, and an IO interface is formed on the upper side of the back circuit board 43, so that control, installation and maintenance are facilitated.
As shown in fig. 5, the lower left fitting space is provided with a power supply 40, a power supply heat dissipation module, a power supply input protection module 27, a hemolytic agent injector 29, a diluent injector 30, a sample injector 31, a reagent presence/absence detection module 32, a third liquid valve module 33, a specific protein reaction cell module 34, a specific protein detection assembly 35, a diluent heating module 36, a press-off valve 37, a DIFF cell module 38, and a fourth liquid valve module 39.
The power supply 40 is installed below the left support plate 9 and near the rear partition 6 to make full use of the inner space of the instrument and to be isolated from the liquid path device at the lower portion of the instrument.
The power supply heat dissipation module is matched with the rear partition plate 6 to dissipate heat, and the power supply input end and the main switch are arranged on the left side of the rear partition plate 6 towards the rear.
The power input protection module 27 is disposed between the power source 40 and the rear partition 6 to prevent human from contacting a strong current.
The hemolytic agent injector 29, the diluent injector 30 and the sample injector 31 are arranged close to the rear partition plate 6 and are positioned below the power input protection module 27 and the power supply 40, and are used for providing pipeline power to perform liquid suction and liquid pushing operations.
The reagent presence/absence detecting module 32 is provided on the bottom plate 5 between the hemolytic agent syringe 29, the diluent syringe 30, the sample syringe 31, and the left door panel 28, and detects the presence/absence of the reagent in the piping.
The third liquid valve module 33 and the fourth liquid valve module 39 are arranged on the middle partition plate 8 and used for controlling the on-off of the pipeline.
The specific protein reaction tank module 34 and the DIFF tank module 38 are embedded and assembled on the middle partition plate 8 through the opening on the middle partition plate 8 and extend into the right lower installation space, and the specific protein reaction tank module 34 and the DIFF tank module 38 are respectively provided with a DIFF tank 61, a specific protein reaction tank 54 and a specific protein reaction tank 57.
The specific protein detection assembly 35 and the diluent heating module 36 are mounted on the bottom plate 5 or the middle partition plate 8, a specific protein detection pool is arranged in the specific protein detection assembly 35, and the specific protein detection pool is connected with the specific protein reaction pool 54 and the specific protein reaction pool 57 through pipelines and used for receiving liquid to be detected prepared by the specific protein reaction pool 54 and the specific protein reaction pool 57 to detect.
The press-shut valve 37 is installed on the middle partition 8.
As shown in fig. 6, the front plate 4 is provided with a fifth liquid valve module 44, a sixth liquid valve module 52, a sheath flow injector 46, a sampling injector 47, a specific protein reagent injector 48, a refrigerated reagent injector 51, an automatic sample introduction platform 49, and a mixing assembly 53.
The fifth liquid valve module 44 and the sixth liquid valve module 52 are respectively located above the left and above the right of the front plate 4, and are used for controlling the on-off of the pipeline.
The sheath flow injector 46, the sampling injector 47 and the specific protein reagent injector 48 are embedded and assembled on the front plate 4 through the left opening on the front plate 4 and extend into the left lower installation space for providing pipeline power to carry out liquid suction and liquid pushing operations.
The refrigerated reagent injector 13 is fitted on the front plate 4 through the right opening in the front plate 4 and extends into the lower right mounting space.
The autoinjection platform 49 is located the bottom of the front plate 4 and is installed on the support 3 for the test tube rack with test tubes in the transmission enters the oversampling station.
The blending component 53 is located at the middle opening of the front plate 4 and used for blending the liquid in the test tube.
In the embodiment of the present invention, the sampling module 50 is mainly composed of a sampling needle, a sampling motion module, a sampling injector 47, a sampling control unit, a sampling cleaning system, and the like.
The sampling motion module comprises a horizontal motion mechanism and a vertical motion mechanism, wherein the horizontal motion mechanism comprises an installation frame and a driving mechanism which horizontally reciprocates. The vertical movement mechanism comprises a driving mechanism which drives the sampling needle to vertically reciprocate.
The sampling needle is internally provided with a needle-shaped structure with a cylindrical cavity. The vertical motion mechanism is installed on a motion slide block of the horizontal motion mechanism to realize horizontal reciprocating motion and vertical reciprocating motion. The sampling motion module is mounted on the instrument septum 8 and extends outside the front plate 4. The sampling motion module can be guided by a linear slide rail, so that the motion precision is ensured, and the pollution to the reaction detection module caused by fragments generated by motion friction can be reduced.
The sampling injector 47 is installed on the front plate 4 and is positioned in the lower left installation space of the middle partition plate 8, and the sampling injector 47 mainly provides power for sucking and discharging a sample by the sampling needle and cleans the inner wall of the sampling needle.
The sampling control component comprises a fifth liquid valve module 44 for controlling the sampling needle to distribute and suck the sampling sample, a pipeline and a corresponding driving circuit, the fifth liquid valve module 44 is arranged at the upper part of the sampling injector 47 so as to facilitate the discharge of bubbles in the sampling injector 47, and the pipeline is connected in series with each functional module.
The sampling and cleaning system comprises a cleaning swab, a liquid pump module 18, a cleaning reagent, diluent, a diluent injector 30, a control valve and a pipeline, wherein the cleaning swab is arranged on a vertical movement mechanism of the sampling movement module, the sampling swab is provided with a cavity through which an axis penetrates and two cavity outlets at different height positions in the radial direction, and a sampling needle moves up and down in the axis cavity. The diluent injector 30 pushes the diluent into the swab from the radial lower side interface of the swab to clean the outer wall of the sampling needle, and the liquid pump module 18 pumps the cleaned reagent out of the outlet at the upper part of the swab through a pipeline to be discharged to an external waste liquid collecting part of the instrument, so that the purpose of cleaning the outer wall of the sampling needle is achieved.
In the embodiment of the invention, the reaction detection module mainly comprises a reagent input module, a DIFF module, a specific protein module system and a blood conventional module, and consists of five linearly distributed cell bodies and detection modules, in one embodiment, the DIFF cell 61, the specific protein reaction cell 54, the specific protein reaction cell 57, the RBC cell 58 and the WBC cell 59 are sequentially arranged in the extending direction from the front plate 4 to the rear partition plate 6, and each cell body is arranged on the middle partition plate 8 at the lower side of the sampling horizontal movement mechanism and is positioned in a relatively closed environment of a lower right installation space, so that the influences of dust, temperature and the like in the external environment of the instrument can be reduced.
Wherein, reagent input module mainly includes reagent interface 45, reagent existence detection module 32 (opto-coupler), liquid valve module, reagent syringe, pipeline, waste liquid discharge interface 60 etc.. The external reagent flows to the reagent injector (hemolytic agent injector 29 and diluent injector 30) through the reagent interface 45 and the reagent existence detection module 32, and is finally distributed into each detection module through the liquid valve module, and related pipelines are also arranged along the trend of gradually rising vertically upwards, so that air bubbles can be conveniently discharged. The reagent presence/absence detection module 32 detects the presence/absence of a reagent in the line.
The DIFF block is used to classify the white blood cells into five categories, including the DIFF pool block 38, the drive system, and the DIFF detection block 10. The DIFF pool module 38 and the press-off valve 37 are mounted on the middle partition plate 8 from the left lower mounting space through mounting plates, the press-off valve 37 is used for controlling the on-off of a pipeline from the DIFF pool 61 to the DIFF detection module 10, the DIFF pool module 38 extends into the right lower mounting space, the press-off valve 37 is arranged on the middle partition plate 8 and is positioned in the left lower mounting space, the DIFF pool module 38 and the press-off valve 37 are mounted on a part and then are fixed on the middle partition plate 8, so that the DIFF pool module 38 and the press-off valve 37 are integrated into a whole to be convenient to assemble, disassemble and maintain, and meanwhile, the influences of short circuit, corrosion and the like caused by liquid overflow in the DI; be provided with heating function and reagent preheating function on the DIFF pond module 38, the reagent that flows in simultaneously passes through earlier and enters into DIFF pond 61 again after preheating, let the reagent reaction environment of DIFF pond 61 be in the homothermal environment, it is convenient for the stability of test result accurate, DIFF detection module 10 sets up on right fagging 37, be located DIFF pond module 38 top position, the distance of DIFF detection module 10 and DIFF pond module 38 to front bezel 4 is less than the distance to back baffle 6, the distance of DIFF detection module 10 to median septum 8 is less than the distance to right door plant 22. After the sampling device 50 adds the sample to be detected into the DIFF pool 61, different reagents are added to react for a period of time, and then the reacted sample is pushed into the DIFF detection module 10 by the injector to be detected.
The specific protein module system is used for detecting the content of specific protein in a sample, and mainly comprises: the reagent kit comprises a refrigerated reagent module 15, an external reagent, a reagent needle assembly 14, a specific protein reaction tank 54, a specific protein reaction tank 57, a specific protein detection assembly 35, a cleaning tank 16, a liquid path control injector, a liquid valve module, a pipeline and the like.
One or more reagents are arranged in the refrigerated reagent module 15, preferably two reagents are arranged in the embodiment, the refrigerated reagent module 15 can store the reagents at constant temperature and low temperature, the reagent sampling port, the cleaning pool 16, the specific protein reaction pool 54 and the specific protein reaction pool 57 of the refrigerated reagent module 15 are arranged at a circumferential position, and the rotating shaft of the reagent needle assembly 14 is arranged at an axial position of the circumference. The reagent needle assembly 14 is provided with reagent needles capable of vertical movement and horizontal circular arc oscillation, the reagent needles take out the reagents from the refrigerated reagent module 15 respectively and add the reagents into the specific protein reaction tank 54 and the specific protein reaction tank 57 respectively, and then the reagent needles are cleaned in the cleaning tank 16, the reagent needles simultaneously have the same cleaning swab and independent cleaning system as the sampling needle, and the influence of reagent performance reduction caused by long-time storage of the reagents in the pipeline can be reduced by adding the reagents through the reagent needles. The specific protein reaction tank module 34 is fixed on the middle partition plate 8 from the left lower mounting space of the middle partition plate 8 through a mounting plate, the specific protein reaction tank 54 and the specific protein reaction tank 57 extend to the right lower mounting space of the middle partition plate 8, and the specific protein reaction tank module 34 is provided with a heating device to enable the specific protein reaction tank 54 and the specific protein reaction tank 57 to be in a constant temperature state; the specific protein detection assembly 35 is arranged on the bottom plate 5 of the lower left installation space and is close to the protein fixing reaction tank 54 and the specific protein reaction tank 57 so as to reduce the interference of vibration, and the specific protein detection assembly 35 has independent heating and temperature control functions; the specific protein module system further comprises a diluent heating module 36, wherein the diluent heating module 36 is used for heating diluent for cleaning the specific protein detection pool to reduce the influence of the cleaning liquid on the temperature of the specific protein detection pool during low-temperature cleaning, and in other embodiments, the specific protein reaction pool 54, the specific protein reaction pool 57, the specific protein detection pool and the diluent heating module 36 may be integrated into one module with constant-temperature heating.
The blood routine detection system mainly comprises a WBC pool 59, a RBC pool 58, a pressure system, a second hydraulic valve module 23, a pipeline and the like. The pressure system includes positive, negative and pressure sensing plates 12 for providing positive and negative pressures during the reaction. In one embodiment: the positive pressure system is pressurized by an air pump 25, a positive pressure air storage tank stores positive pressure air, the second liquid module 23 is controlled, the air pump 25 is arranged on the upper side of the middle partition plate 8 of the instrument and can be positioned in the upper right installation space so as to reduce the influence of vibration on the performance of the instrument, and the second liquid module 23 is arranged between the air pump 25 and the pressure chamber 19 in the vertical direction; the negative pressure is established by the air pump 25, the negative pressure gas storage tank stores negative pressure gas, and the second hydraulic valve module 23 and the pipeline are controlled; the second hydraulic valve module 23 is disposed at a position between the air pump 25 and the pressure chamber 19 in the vertical direction; the positive pressure chamber and the negative pressure chamber are installed on the same horizontal plane, the distance from the bottom plate 5 is less than the distance to the right support plate 7, and the pressure detection plate 12 is arranged on the right support plate 37 near the front plate 4. In other embodiments, positive and negative pressure can be established by an air pump 25, and the pressure chamber 19 can be eliminated, by lengthening the line between the valves for pressure stabilization.
The waste liquid treatment module comprises a liquid pump module 18, a second liquid valve module 20, a waste liquid pipe and a waste liquid discharge interface 60. The liquid pump module 18 is arranged on the bottom plate 5, the distance from the liquid pump module 18 to the right door plate 22 is smaller than that to the middle partition plate 8, and the second liquid valve module 20 is arranged at the position, close to the liquid pump module 18, of the right rear partition plate 6.
The blood cell analyzer provided by the invention has the advantages of compact structure and convenience in maintenance.
Referring to fig. 11 to 18, the reagent bottle storage module includes a cover plate 1, a box 3, an air outlet cover 4, a bracket 7, a refrigeration bottom plate 8, a hinge 9, a first positioning portion 10, a second positioning portion 11, a condensed water guiding member 12, a thermal insulation cotton 13, a micro switch 31, an air inlet cover 15, a heat dissipation module 16, a reagent bottle storage module 17, and a cold guiding plate 121.
The box body 3 includes a bottom wall and a surrounding wall connected to the bottom wall, and a space formed by the bottom wall and the surrounding wall is used for storing the reagent bottles 2 in a refrigerated manner, for example, two reagent bottles 2 shown in fig. 12, of course, the number of the reagent bottles 2 is not limited, and may be 1, 3, 5, and the like, and the box body 3 may be in a rectangular box shape or a circular box shape.
The cover plate 1 is arranged at the top of the enclosing wall and used for opening or closing the box body 3, the cover plate 1 can also be in a rectangular box body shape or a circular box body shape, the cover plate 1 is provided with a through reagent sampling hole 101, and the reagent sampling hole 101 is opposite to the bottle mouth of the reagent bottle 2 so that a reagent needle (not shown) can penetrate through the reagent sampling hole 101 to suck the reagent in the reagent bottle 2.
The condensed water guide 12 is disposed on the inner surface side of the cover plate 1, the condensed water guide 12 is disposed on the side of the reagent sampling hole 101 and is staggered with the bottle mouth of the reagent bottle 2 to prevent condensed water from dripping into the reagent bottle 2 to contaminate the reagent, the number of the condensed water guides 12 is not limited, and may be 1, 2, 3, 4, 5, or 6, and the like, and when the number is plural, the condensed water guides may be disposed around the reagent sampling hole 101.
In an embodiment, the condensed water guiding member 12 may be a metal member, such as a metal pin, a metal sphere or a metal bump, the cross-sectional area of the free end of the condensed water guiding member 12 may be gradually reduced so that the air is liquefied and condensed into water drops to drop along with the water drops after encountering the condensed water guiding member 12, the reagent sampling hole 101 may be a straight hole or a step hole, when the reagent sampling hole 101 is in the step hole shape, the reagent sampling hole 101 includes a large hole 102 recessed in the inner surface of the cover plate 1 and a small hole 103 penetrating through the outer surface of the cover plate 1, the condensed water guiding member 12 may be disposed in the large hole 102 to shorten the distance between the outside air and the condensed water guiding member 12, so that the outside air immediately contacts the cooler condensed water guiding member 12 to be liquefied to form condensed water after.
The heat insulation cotton 13 is attached to the inner surface of the cover plate 1, the heat insulation cotton 13 is provided with a through hole 131 which is aligned with the reagent sampling hole 101, the aperture of the through hole 131 is larger than the diameter of the small hole 103 and smaller than the diameter of the large hole 102, therefore, the aperture of the air channel of the reagent sampling hole 101 can be properly reduced, the cold insulation is better, the condensed water guide piece 12 protrudes out of the heat insulation cotton 13, the condensed water guide piece 12 extends into the box body 3 to contact with the cold air in the box body 3, the temperature of the condensed water guide piece is relatively lower, its temperature is less than the outside air around the reagent thief hole 101, and outside air meets microthermal comdenstion water guide 12 and can liquefy and form the comdenstion water after getting into box 3 through reagent thief hole 101, and partial comdenstion water can be adsorbed by heat preservation cotton 13 and collect, and partial comdenstion water drips along the free end of comdenstion water guide 12, and the bottom of box 3 is equipped with overflow mouth 14, and overflow mouth 14 is used for connecting line and power supply in order to arrange outward the comdenstion water suction in the box 3.
The reagent bottle storage module 17 comprises a bottom block and a plurality of parallel side blocks arranged at intervals, a containing groove for containing the reagent bottle 2 is formed between every two adjacent side blocks, and the reagent bottle storage module 17 is made of materials with high heat conductivity coefficient.
The box 3 is supported at a certain height through the support 7, the refrigeration bottom plate 8 comprises a refrigeration block 20, a refrigeration piece 19 and a temperature sensor 13, the refrigeration block 20 and the temperature sensor 13 are embedded in the refrigeration bottom plate 8, and the refrigeration piece 19 is attached to the lower surface of the refrigeration block 20.
The heat dissipation module 16 is in contact with the refrigeration block 20 and is located in the support 7 and used for dissipating heat of the refrigeration bottom plate 8, the heat dissipation module 16 can comprise components such as a heat absorption plate, a heat pipe, heat dissipation fins, a fan and the like, two ends of the heat dissipation module 16 are respectively connected with the air inlet cover 15 and the air outlet cover 4, and an air inlet of the air inlet cover is correspondingly provided with a dust screen to prevent foreign matters such as dust from entering.
As shown in fig. 1 and 5, the condensed water guide 12 may be disposed on an inner surface side of the cover plate 1 through the cold guide plate 121, when the cover plate 1 covers the box body 3, at least one side block of the reagent bottle storage module 17 abuts against the cold guide plate 121, and compared with the air cooling through the box body 3, the condensed water guide 12 may be cooled more quickly and have a better cooling effect by conducting the cold through the reagent bottle storage module 17 and the cold guide plate 121 in sequence.
The cover plate 1 can be connected with the box body 3 in a rotating or sliding manner, as shown in fig. 11, when the cover plate 1 is connected with the box body 3 in a rotating manner, the refrigerated reagent module further includes a hinge 9, one side of the hinge 9 is connected with the box body 3, the other side of the hinge 9 is connected with the cover plate 1, the box body 3 is provided with a first positioning portion 10 at the side of the hinge 9, the cover plate 1 is provided with a second positioning portion 11 at the side of the hinge 9, when the cover plate 1 is opened in a rotating manner with respect to the box body 3, the second positioning portion 11 is supported by the first positioning portion 10 so that the cover plate 1 is opened in a positioning manner with respect to the box body 3 and is kept at a predetermined position, the first positioning portion 10 and the second positioning portion 11 can both be nonmagnetic parts, or one of the first positioning portion 10 and the second positioning portion 11 is a magnet. When the cover plate 1 is rotationally and slidably connected with the box body 3, the cover plate can be in one-way sliding as shown in fig. 17 or in two-way sliding as shown in fig. 18, when the two-way sliding is adopted, the cover plate 1 is only half opened during the operation of replacing the reagent bottle 2, the loss of cold energy can be properly reduced, and when the cover plate 1 is fully opened during the operation of replacing the reagent bottle 2 during the rotational connection and the one-way sliding connection, the cold energy is easy to lose.
The side of the box body 3 is provided with an open slot 105, the side of the reagent bottle 2 is provided with a guide rib 21 matched with the open slot 105 so as to facilitate guiding and foolproof assembly, and the top of the reagent bottle 2 is also provided with a lifting piece 22 so as to facilitate taking and placing the reagent bottle 2.
The microswitch 31 is arranged at the buckling end of the box body 3 or the cover plate 1 and is used for detecting the opening or closing state of the cover plate 1 relative to the box body 3.
The invention also provides a blood analyzer, which comprises a control and information processing module, a sample collecting and distributing device, a reagent collecting and distributing device, a specific protein measuring device, a blood conventional measuring device and the refrigerated reagent module which are electrically connected.
The sample collection and distribution device is used for collecting samples and distributing the collected samples to the blood routine measuring device. The sample collection and dispensing device includes a sample needle and a hydrodynamic device such as a syringe, a dosing pump, and the like. The sample is mainly a blood-related sample
The reagent collecting and distributing device is used for collecting reagents and distributing the collected reagents to the specific protein measuring device. The reagent collecting and distributing device comprises a reagent needle and a liquid power device such as a syringe, a quantitative pump and the like. The reagent may be an antibody reagent, a hemolysis reagent, or the like.
The blood routine measuring device is used for providing a measuring place for the distributed sample, measuring the distributed sample to obtain at least one blood routine parameter and outputting a measuring result.
The specific protein measuring device is used for providing a measuring place for the distributed blood, measuring the distributed sample to obtain the specific protein parameter and outputting the measuring result.
The refrigerated reagent module is used for providing a low-temperature preservation environment for the reagent.
A fluid path support device for providing fluid path support for the sample collection and distribution device, the reagent collection and distribution device, the blood routine measurement device, and the specific protein measurement device.
The control and information processing module is used for controlling the sample collecting and distributing device to collect and distribute samples, controlling the reagent collecting and distributing device to collect and distribute reagents, controlling the liquid path supporting module to carry out fluid conveying, receiving the measuring result output by the specific protein measuring device and processing the measuring result. Preferably, the fluid circuit support apparatus includes a reagent delivery line in communication with a reagent bottle in the refrigerated reagent module.
Preferably, the fluid circuit support means comprises a reagent delivery conduit in communication with a reagent needle in the reagent collection and dispensing means.
Preferably, the blood analyzer further comprises a blood routine detection device.
Referring to fig. 11 to 21, the present invention further provides a refrigerated reagent module, which includes a cover plate 1, a box body 3 and a bracket 7.
The box body 3 comprises a bottom wall and a surrounding wall connected with the bottom wall, and a space formed by the bottom wall and the surrounding wall is used for storing the reagent bottles 2 in a refrigerating way, such as two reagent bottles 2 shown in fig. 2, of course, the number of the reagent bottles 2 is not limited, and can be 1, 3, 5 and the like, and the box body 3 can be in a rectangular box shape or a circular box shape.
The cover plate 1 is arranged at the top of the enclosing wall and used for opening or closing the box body 3, the cover plate 1 can also be in a rectangular box body shape or a circular box body shape, the cover plate 1 is provided with a through reagent sampling hole 101, and the reagent sampling hole 101 is opposite to the bottle mouth of the reagent bottle 2 so that a reagent needle (not shown) can penetrate through the reagent sampling hole 101 to suck the reagent in the reagent bottle 2.
The bottom edge of the bracket 7 is provided with a first movable mating member 71, the first movable mating member 71 can be a guide rail or a pulley and the like, the inner end of the bracket 7 is provided with a first sensing component 71 used for sensing the pushing-in-place condition in a matching manner, and the outer side of the bracket 7 is provided with a handle 72 so as to facilitate the pulling-out and pushing-in operations of the bracket.
The refrigerated reagent module further comprises an air outlet cover 4, a refrigerating bottom plate 8, a hinge 9, a first positioning part 10, a second positioning part 11, a condensed water guide part 12, heat preservation cotton 13, a microswitch 31, an air inlet cover 15, a heat dissipation module 16, a reagent bottle storage module 17 and a cold guide plate 121.
The condensed water guide 12 is disposed on the inner surface side of the cover plate 1, the condensed water guide 12 is disposed on the side of the reagent sampling hole 101 and is staggered with the bottle mouth of the reagent bottle 2 to prevent condensed water from dripping into the reagent bottle 2 to contaminate the reagent, the number of the condensed water guides 12 is not limited, and may be 1, 2, 3, 4, 5, or 6, and the like, and when the number is plural, the condensed water guides may be disposed around the reagent sampling hole 101.
The condensed water guide 12 may be a metal member, such as a metal pin, the cross-sectional area of the free end of the condensed water guide 12 may be gradually reduced so that the water drops condensed by liquefaction after the air meets the condensed water guide 12 may drop along the way, the reagent sampling hole 101 may be a straight hole or a step hole, when the reagent sampling hole 101 is in the step hole shape, the reagent sampling hole 101 includes a large hole 102 recessed in the inner surface of the cover plate 1 and a small hole 103 penetrating through the outer surface of the cover plate 1, the condensed water guide 12 may be disposed in the large hole 102 to shorten the distance between the outside air and the condensed water guide 12, so that the outside air immediately contacts the cooler condensed water guide 12 to liquefy to form condensed water after entering the reagent sampling hole 101, and the outside air.
The heat insulation cotton 13 is attached to the inner surface of the cover plate 1, the heat insulation cotton 13 is provided with a through hole 131 which is aligned with the reagent sampling hole 101, the aperture of the through hole 131 is larger than the diameter of the small hole 103 and smaller than the diameter of the large hole 102, therefore, the aperture of the air channel of the reagent sampling hole 101 can be properly reduced, the cold insulation is better, the condensed water guide piece 12 protrudes out of the heat insulation cotton 13, the condensed water guide piece 12 extends into the box body 3 to contact with the cold air in the box body 3, the temperature of the condensed water guide piece is relatively lower, its temperature is less than the outside air around the reagent thief hole 101, and outside air meets microthermal comdenstion water guide 12 and can liquefy and form the comdenstion water after getting into box 3 through reagent thief hole 101, and partial comdenstion water can be adsorbed by heat preservation cotton 13 and collect, and partial comdenstion water drips along the free end of comdenstion water guide 12, and the bottom of box 3 is equipped with overflow mouth 14, and overflow mouth 14 is used for connecting line and power supply in order to arrange outward the comdenstion water suction in the box 3.
The reagent bottle storage module 17 comprises a bottom block and a plurality of parallel side blocks arranged at intervals, a containing groove for containing the reagent bottle 2 is formed between every two adjacent side blocks, and the reagent bottle storage module 17 is made of materials with high heat conductivity coefficient.
The box 3 is supported at a certain height through the support 7, the refrigeration bottom plate 8 comprises a refrigeration block 20, a refrigeration piece 19 and a temperature sensor 13, the refrigeration block 20 and the temperature sensor 13 are embedded in the refrigeration bottom plate 8, and the refrigeration piece 19 is attached to the lower surface of the refrigeration block 20.
The heat dissipation module 16 is in contact with the refrigeration block 20 and is located in the support 7 and used for dissipating heat of the refrigeration bottom plate 8, the heat dissipation module 16 can comprise components such as a heat absorption plate, a heat pipe, heat dissipation fins, a fan and the like, two ends of the heat dissipation module 16 are respectively connected with the air inlet cover 15 and the air outlet cover 4, and an air inlet of the air inlet cover is correspondingly provided with a dust screen to prevent foreign matters such as dust from entering.
As shown in fig. 5, the condensed water guide 12 may be disposed on an inner surface side of the cover plate 1 through the cold guide plate 121, and when the cover plate 1 covers the box body 3, at least one side block of the reagent bottle storage module 17 is in contact with the cold guide plate 121, so that compared with the air cooling in the box body 3, the condensed water guide 12 may be cooled more quickly and have a better cooling effect by conducting the cold through the reagent bottle storage module 17 and the cold guide plate 121 in sequence.
The cover plate 1 can be connected with the box body 3 in a rotating or sliding manner, as shown in fig. 1, when the cover plate 1 is connected with the box body 3 in a rotating manner, the refrigerated reagent module further includes a hinge 9, one side of the hinge 9 is connected with the box body 3, the other side of the hinge 9 is connected with the cover plate 1, the box body 3 is provided with a first positioning portion 10 at the side of the hinge 9, the cover plate 1 is provided with a second positioning portion 11 at the side of the hinge 9, when the cover plate 1 is opened in a rotating manner relative to the box body 3, the second positioning portion 11 is supported by the first positioning portion 10 so that the cover plate 1 is opened in a positioning manner relative to the box body 3 and is kept at a predetermined position, the first positioning portion 10 and the second positioning portion 11 can both be nonmagnetic parts, or one of the first positioning portion 10 and the second positioning portion 11 is a magnet, and. When the cover plate 1 is in rotary sliding connection relative to the box body 3, the cover plate can be in one-way sliding as shown in fig. 7 or in two-way sliding as shown in fig. 8, when the two-way sliding is adopted, the cover plate 1 is only half opened during the operation of replacing the reagent bottle 2, the loss of cold energy can be properly reduced, and when the cover plate 1 is completely opened during the operation of replacing the reagent bottle 2 during the rotary connection and the one-way sliding connection, the cold energy is easy to lose.
The side of the box body 3 is provided with an open slot 105, the side of the reagent bottle 2 is provided with a guide rib 21 matched with the open slot 105 so as to facilitate guiding and foolproof assembly, and the top of the reagent bottle 2 is also provided with a lifting piece 22 so as to facilitate taking and placing the reagent bottle 2.
The microswitch 31 is arranged at the buckling end of the box body 3 or the cover plate 1 and is used for detecting the opening or closing state of the cover plate 1 relative to the box body 3.
The invention also provides a blood analyzer, which comprises the refrigerated reagent module and the main cabinet 200, wherein the main cabinet 200 comprises a top plate 201, a front plate 202, a back plate, a side plate 204 and a bottom plate 5 which are connected with each other, the side plate 204 is provided with an opening, a second movable matching part, such as a guide rail or a guide groove, is arranged in the main cabinet 200 corresponding to the first movable matching part 71, and a matched second sensing part is arranged corresponding to the first sensing part 73 so as to detect the pushing in-place condition of the support 7, after the support 7 is pulled out in the X direction through the handle 72, the cover plate 1 can be opened in the Y direction relative to the cabinet 3, the extending direction of the corresponding hinge 9 is parallel to the pulling-out direction, or when the cover plate 1 is connected with the cabinet 3 in a sliding manner, the sliding opening direction can be set to be vertical to the pulling-out direction.
The blood analyzer also comprises a control and information processing module, a sample collecting and distributing device, a reagent collecting and distributing device, a specific protein measuring device, a blood routine measuring device and the refrigerated reagent module which are electrically connected.
The sample collection and distribution device is used for collecting samples and distributing the collected samples to the blood routine measuring device. The sample collection and dispensing device includes a sample needle and a hydrodynamic device such as a syringe, a dosing pump, and the like. The sample is primarily a blood-related sample.
The reagent collecting and distributing device is used for collecting reagents and distributing the collected reagents to the specific protein measuring device. The reagent collecting and distributing device comprises a reagent needle and a liquid power device such as a syringe, a quantitative pump and the like. The reagent may be an antibody reagent, a hemolysis reagent, and the like, including but not limited to an immunological reagent, such as a CRP reagent, a SAA reagent, a ferritin reagent, and the like.
The blood routine measuring device is used for providing a measuring place for the distributed sample, measuring the distributed sample to obtain at least one blood routine parameter and outputting a measuring result.
The specific protein measuring device is used for providing a measuring place for the distributed sample, measuring the distributed sample to obtain the specific protein parameter and outputting a measuring result, wherein the sample is mainly a blood related sample.
The refrigerated reagent module is used for providing a low-temperature preservation environment for the reagent.
A fluid path support device for providing fluid path support for the sample collection and distribution device, the reagent collection and distribution device, the blood routine measurement device, and the specific protein measurement device.
The control and information processing module is used for controlling the sample collecting and distributing device to collect and distribute samples, controlling the reagent collecting and distributing device to collect and distribute reagents, controlling the liquid path supporting module to carry out fluid conveying, receiving the measuring result output by the specific protein measuring device and processing the measuring result. Preferably, the fluid circuit support apparatus includes a reagent delivery line in communication with a reagent bottle in the refrigerated reagent module.
Preferably, the fluid circuit support means comprises a reagent delivery conduit in communication with a reagent needle in the reagent collection and dispensing means.
The refrigerated reagent module 110 provided by the embodiment has a novel structure, is simple to manufacture, and is convenient to disassemble, assemble and maintain.
The present embodiment provides a detection apparatus, as shown in fig. 22 to 27, which includes a stand 100, a heating component, a specific protein detection component 35, and an optical detection cell 120.
As shown in fig. 23, the vertical frame 100 may be a metal support or a plastic support, and is fixedly assembled in the housing of the analyzer, the heating assembly may be obliquely fixed on the vertical frame 100, the heating assembly includes a heating block 110, the heating block 110 may be made of aluminum material or copper material, the heating block 110 is provided with a plurality of assembling cavities 113 for receiving the optical detection cells 120, the volumes of the assembling cavities 113 are matched with the volumes of the optical detection cells 120, the assembling cavities 113 fully surround the optical detection cells 120, only the bottom end surfaces of the optical detection cells 120 are exposed, the contact areas between the heating block 110 and the optical detection cells 120 are large, the heat conduction effect is good, and the liquid to be detected in the optical detection cells 120 can be well temperature controlled. The specific protein detection assembly 35 is fixed with the heating block 110, the specific protein detection assembly 35 comprises a base body 130, the base body 130 is provided with a notch 134 matched with the heating block 110 in a clamping mode, and the optical detection cell 120 is arranged in the notch 134 and is loaded into the assembly cavity 113 through the support of the base body 130.
As shown in fig. 23, 28, and 29, the heating block 110 further has a light through hole 114 penetrating through the assembly cavity 113, the substrate 130 further has a light inlet channel 133, a first light outlet channel 131, and a second light outlet channel 132, the gap 134 is disposed between the light inlet channel 133 and the first light outlet channel 131 and the second light outlet channel 132, the light inlet channel 133 is aligned with the first light outlet channel 131, an axis of the second light outlet channel 132 is inclined with respect to an axis of the first light outlet channel 131, and the light through hole 114 is aligned with the light inlet channel 133 when the specific protein detection assembly 35 is fixed to the heating block 110.
In order to fix the specific protein detection assembly 35 and the heating block 110, an assembly plate 136 is integrally extended from one side of the notch 134 close to the light inlet channel 133 of the base 130, a first assembly hole 137 is formed in the assembly plate 136, a first connection hole 111 is formed in a side wall of the heating block 110 corresponding to the first assembly hole 137, the specific protein detection assembly 35 can be locked with respect to the heating block 110 by passing a screw through the first assembly hole 137 and screwing the screw into the first connection hole 111, and the first connection hole 111 is located at a side edge of the light through hole 114.
Further, the base 130 is further provided with a second assembly hole 138 penetrating to the bottom of the notch 134, the bottom end of the heating block 110 is provided with a second connection hole 112 corresponding to the second assembly hole 138, the specific protein detection assembly 35 can be locked with respect to the heating block 110 by passing a screw through the second assembly hole 138 and screwing the screw into the second connection hole 112, and the second connection hole 112 is located at the side of the assembly cavity 113.
In the embodiment of the present invention, the assembly cavity 113 is a plurality of parallel cavities, for example, 6 cavities as shown in fig. 23, the specific protein detection assembly 35 and the optical detection cell 120 are all a plurality of cavities, the sidewall of the heating block 110 is further provided with a plurality of sets of guide ribs 115 in parallel and at intervals, so that the notch 134 and the assembly plate 136 of the base 130 are aligned and clamped with the heating block 110, and the extending direction of the guide ribs 115 is parallel to the extending direction of the assembly cavity 113.
As shown in fig. 23 and 25, the detection device further includes a waterproof sealing ring 101, the optical detection cell 120 includes a liquid injection tube 125, the top end of the heating block 110 is provided with a through hole 116 communicated with the assembly cavity 113 to allow the liquid injection tube 125 to extend out, the waterproof sealing ring 101 is located in the assembly cavity 113, is sleeved on the periphery of the liquid injection tube 125, and is clamped between the optical detection cell 120 and the heating block 110, so that external liquid can be prevented from entering the optical detection cell 120 to affect the detection result.
As shown in fig. 22 and 23, the heating block 110 is obliquely fixed on the stand 100 such that the assembly chamber 113 is obliquely disposed, and the optical detection cell 120 and the specific protein detection assembly 35 are obliquely disposed relative to the horizontal plane.
The detection device further comprises a pipeline heating assembly 300, the pipeline heating assembly 300 is used for winding a pipeline and heating the pipeline, the vertical frame 100 comprises a first support arm 102 and a second support arm 104, the heating block 110 is fixed through the first support arm 102, the pipeline heating assembly 300 is arranged on the side edge of the heating block 110 through the second support arm 104, and the pipeline heating assembly 300 is lower than the liquid injection pipe 125, so that the pipeline wound on the pipeline heating assembly 300 can be bent and butted with the liquid injection pipe 125 with smaller curvature when being led out, the bubble discharge can be facilitated, the bubble problem can be reduced, if the pipeline heating assembly 300 is higher than the liquid injection pipe 125, the pipeline wound on the pipeline heating assembly 300 is bent with larger curvature and butted with the liquid injection pipe 125 when being led out, the bubbles are not easy to discharge, and the relatively serious bubble problem can be generated.
As shown in fig. 25 to 27, the heating assembly further includes a heating film 117, a temperature sensor 118 and an over-temperature protection switch 119, the heating block 110 may be made of a material with good thermal conductivity, such as aluminum or copper, the heating film 117 is attached to the surface of the heating block 110, and the temperature sensor 118 and the over-temperature protection switch 119 are embedded in the heating block 110. The two ends of the heating block 110 can be provided with mounting holes 103 to be fixed with the first support arm 102 of the stand 100, the surface of the heating block 110 for attaching the heating film 117 can be provided with a protrusion 106, the protrusion 106 enables the cross section of the heating block 110 to be L-shaped, and the over-temperature protection switch 119 can be embedded in the protrusion 106, so that the structure of the heating block 110 can be compact.
The detection device provided by the embodiment has a novel structure, the optical detection cell 120 is arranged in the notch part 134 and is loaded into the assembly cavity through the support of the base body 130, the assembly and disassembly are convenient, the maintenance is facilitated, the influence of water leakage on the detection device can be reduced, and the problem of bubbles can be reduced. The embodiment also provides a sample analyzer, which comprises the detection device.

Claims (20)

1. A blood cell analyzer, comprising:
a frame;
a housing covering the chassis;
the system comprises a plurality of cell bodies, a plurality of cell bodies and a plurality of detection cells, wherein the cell bodies are distributed linearly or in an arc shape and comprise a specific protein reaction cell and a blood conventional detection cell;
the sampling module is arranged on the rack and used for performing complex motion relative to the rack so as to sample and sample the plurality of cell bodies;
the reagent needle assembly is arranged on the rack and can perform swing motion so as to correspondingly swing to the specific protein reaction tank or perform triaxial motion so as to correspondingly move to the specific protein reaction tank.
2. The blood cell analyzer according to claim 1, wherein:
when the reagent needle assembly performs swing motion, the specific protein reaction tank, the cleaning tank and the refrigerated reagent tank are distributed on a swing track of the reagent needle assembly;
the blood routine detection pool comprises a DIFF pool, an RBC pool and a WBC pool which are positioned at the lower side of the sampling module.
3. The blood cell analyzer according to claim 2, wherein:
the rack comprises a supporting piece, a front plate, a bottom plate, a rear clapboard, a right supporting plate, a middle clapboard and a left supporting plate;
the supporting piece is arranged below the bottom plate and protrudes out of the front plate;
a heat dissipation air inlet and an air outlet are formed in the right side of the bottom plate, and a filter screen is mounted on the air inlet;
the middle partition board is vertically connected with the front board, the bottom board and the rear partition board, and the left support board and the right support board are respectively positioned at the left side and the right side of the middle partition board and are vertically connected with the front board and the rear partition board so as to divide the rack into an upper left assembly space, a lower left assembly space, an upper right assembly space and a lower right assembly space;
the sampling module is installed on the middle partition plate and extends out of the lower right installation space through the middle opening in the front plate.
4. The blood cell analyzer according to claim 3, wherein:
the rear bulkhead 6 is provided in a concave shape for accommodating cables and/or pipes.
5. The blood cell analyzer according to claim 3, wherein:
the shell comprises an upper shell, a lower shell, a top cover, a left door plate, a right door plate and a rear cover;
the upper shell is mounted on the front plate through a hinge and is adsorbed and/or buckled on the front plate through a magnetic part and/or a buckling part;
the left door panel and/or the right door panel are/is mounted on the rear partition plate through a hinge and are/is adsorbed and/or buckled on the rear partition plate through a magnetic part and/or a buckling part;
the top cover is arranged on the top of the rack;
the rear cover is arranged on the rear partition board, and the left end corner area and the right end corner area of the rear cover are respectively provided with a reagent interface and a waste liquid discharge interface.
6. The blood cell analyzer according to claim 3, wherein:
the upper right assembly space is provided with a DIFF detection module, an automatic sample injection driving circuit board, a pressure detection circuit board, a temperature control circuit board and an air pump;
the DIFF detection module, the automatic sample feeding driving circuit board and the pressure detection circuit board are close to the front plate;
the temperature control circuit board and the air pump are close to the rear partition plate.
7. The blood cell analyzer according to claim 3, wherein:
the reagent needle assembly, the refrigerated reagent module, the cleaning pool, the blood routine module, the liquid pump module, the pressure chamber, the first liquid valve module, the swab filter and the second liquid valve module are assembled in the lower right assembly space;
the reagent needle assembly is mounted on the base plate;
the chilled reagent module is mounted on the floor remote from the midplate;
the cleaning pool is arranged on the bottom plate and is positioned on the side edge of the refrigerated reagent module;
the blood routine module is mounted on the base plate and provided with the RBC pool and the WBC pool;
the liquid pump module is mounted on the bottom plate and is positioned between the refrigerated reagent module and the rear partition;
the first liquid valve module is arranged on the rear partition plate;
the pressure chamber is fixed through the rear partition plate and/or the middle partition plate and is positioned on one side, facing the middle partition plate, of the first liquid valve module;
the swab filter and the second liquid valve module are arranged on the rear partition plate and are sequentially positioned above the pressure chamber.
8. The blood cell analyzer according to claim 3, wherein:
the upper left assembling space is provided with a driving plate, a spacing metal plate, a main control plate and a back circuit board;
the driving plate is mounted on the left supporting plate;
the spacing metal plate support is fixed on the left support plate;
the main control board is arranged on the spacing metal plate;
the back circuit board is arranged on the spacing metal plate and is vertically installed with the main control board.
9. The blood cell analyzer according to claim 3, wherein:
the left lower assembly space is provided with a power supply, a power supply input protection module, a hemolytic agent injector, a diluent injector, a sample injector, a reagent existence detection module, a third liquid valve module, the specific protein reaction tank module, a specific protein detection assembly, a diluent heating module, a press-break valve, a DIFF tank module and a fourth liquid valve module;
the power supply is arranged below the left supporting plate and close to the rear clapboard;
the power input protection module is arranged between a power supply and the rear partition plate;
the hemolytic agent injector, the diluent injector and the sample injector are arranged close to the rear partition plate and are positioned below the power supply input protection module and the power supply;
the reagent existence detection module is arranged on the bottom plate and is positioned among the hemolytic agent injector, the diluent injector, the sample injector and the left door plate;
the third liquid valve module and the fourth liquid valve module are arranged on the middle partition plate;
the specific protein reaction tank module and the DIFF tank module are embedded and assembled on the middle partition plate through an opening on the middle partition plate and extend into the lower right mounting space, and the DIFF tank and the specific protein reaction tank are respectively arranged on the specific protein reaction tank module and the DIFF tank module;
the specific protein detection assembly and the diluent heating module are arranged on the bottom plate or the middle partition plate;
the pressure-breaking valve is installed on the middle partition plate.
10. The blood cell analyzer according to claim 3, wherein:
the front plate is provided with a fifth liquid valve module, a sixth liquid valve module, a sheath flow injector, a sampling injector, a specific protein reagent injector, a refrigerated reagent injector, an automatic sample introduction platform and a blending assembly;
the fifth liquid valve module and the sixth liquid valve module are respectively positioned at the upper left and the upper right of the front plate;
the sheath flow injector, the sampling injector and the specific protein reagent injector are embedded and assembled on the front plate through the left opening of the front plate and extend into the left lower mounting space;
the refrigerated reagent injector is embedded and assembled on the front plate through the right opening on the front plate and extends into the lower right mounting space;
the automatic sample introduction platform is positioned at the bottom of the front plate and is arranged on the supporting piece;
the blending component is positioned at the middle opening on the front plate.
11. The hematology analyzer of claim 7, wherein the chilled reagent module comprises:
the box body is used for storing reagent bottles;
the cover plate is used for opening or closing the box body, and is provided with a through reagent sampling hole which is opposite to the bottle mouth of the reagent bottle;
and the condensed water guide piece is arranged on the inner surface side of the cover plate, is arranged on the side edge of the reagent sampling hole and is staggered with the bottle mouth of the reagent bottle.
12. The hematology analyzer of claim 11, wherein the condensed water guide is a metal member; and/or the reagent sampling hole is in a step hole shape and comprises a large hole sunken in the inner surface of the cover plate and a small hole penetrating through the outer surface of the cover plate, and the condensed water guide piece is arranged in the large hole; and/or the free end of the condensate guide is tapered in cross-sectional area.
13. The hematology analyzer of claim 11, wherein the refrigerated reagent module further comprises a heat-insulating cotton attached to an inner surface of the cover plate, the heat-insulating cotton is provided with a through hole aligned with the reagent sampling hole, and the condensed water guide protrudes from the heat-insulating cotton; and/or the bottom of the box body is provided with an overflow port, and the overflow port is used for discharging the condensed water in the box body.
14. The hematology analyzer of claim 11, wherein the refrigerated reagent module further comprises a reagent bottle storage module, the reagent bottle storage module comprises a plurality of side blocks, and a containing groove for containing the reagent bottle is formed between two adjacent side blocks.
15. The hematology analyzer of claim 11, wherein the cover plate is rotatably or slidably coupled with respect to the housing; and/or when the cover plate is rotationally connected relative to the box body, the refrigerated reagent module further comprises a hinge, one side edge of the hinge is connected with the box body, and the other side edge of the hinge is connected with the cover plate; and/or the box body is provided with a first positioning part at the side edge of the hinge, the cover plate is provided with a second positioning part at the side edge of the hinge, and when the cover plate rotates and opens relative to the box body, the second positioning part is supported by the first positioning part so that the cover plate is positioned and opened relative to the box body and is kept at a preset position; and/or the first positioning part and the second positioning part are both non-magnetic pieces, or one of the first positioning part and the second positioning part is a magnet, and the other is a magnet or a magnetic metal piece.
16. The blood cell analyzer according to claim 9, characterized in that the blood cell analyzer comprises:
erecting a frame;
the heating assembly is fixed on the vertical frame and comprises a heating block, and the heating block is provided with an assembly cavity for receiving the optical detection cell;
the specific protein detection assembly is fixed with the heating block and comprises a base body, and the base body is provided with a notch part matched with the heating block in a clamping manner;
and the optical detection cell is arranged in the gap part and is loaded into the assembly cavity through the bearing of the base body.
17. The hematology analyzer of claim 16, wherein the heating block further has a light through hole penetrating the assembly cavity, the base further has a light entrance channel, a first light exit channel and a second light exit channel, the notch portion is disposed between the light entrance channel and the first light exit channel and between the light entrance channel and the second light exit channel, the light entrance channel is aligned with the first light exit channel, an axis of the second light exit channel is inclined relative to an axis of the first light exit channel, and the light through hole is aligned with the light entrance channel when the specific protein detection assembly is fixed to the heating block.
18. The hematology analyzer of claim 17, wherein a mounting plate is integrally extended from the base at a side of the notch portion close to the light inlet channel, a first mounting hole is formed in the mounting plate, a first connecting hole is formed in a side wall of the heating block corresponding to the first mounting hole, and the first connecting hole is located at a side of the light through hole.
19. The hematology analyzer of claim 17, further comprising a waterproof sealing ring, wherein the optical detection cell comprises a cell body and a liquid injection tube, the top end of the heating block is provided with a through hole communicated with the assembly cavity to allow the liquid injection tube to extend out, and the waterproof sealing ring is located in the assembly cavity, sleeved on the periphery of the liquid injection tube and clamped between the optical detection cell and the heating block.
20. The hematology analyzer of claim 19, wherein the detecting device further comprises a tube heating assembly for winding and heating a tube, the stand comprises a first arm and a second arm, the heating block is fixed by the first arm, the tube heating assembly is disposed on a side of the heating block by the second arm, and the tube heating assembly is lower than the liquid injection tube.
CN201911330887.XA 2019-12-20 2019-12-20 Blood cell analyzer Pending CN113009164A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911330887.XA CN113009164A (en) 2019-12-20 2019-12-20 Blood cell analyzer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911330887.XA CN113009164A (en) 2019-12-20 2019-12-20 Blood cell analyzer

Publications (1)

Publication Number Publication Date
CN113009164A true CN113009164A (en) 2021-06-22

Family

ID=76382641

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911330887.XA Pending CN113009164A (en) 2019-12-20 2019-12-20 Blood cell analyzer

Country Status (1)

Country Link
CN (1) CN113009164A (en)

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